X-Git-Url: http://source.jalview.org/gitweb/?a=blobdiff_plain;f=src%2Fjalview%2Fext%2Fensembl%2FEnsemblSeqProxy.java;fp=src%2Fjalview%2Fext%2Fensembl%2FEnsemblSeqProxy.java;h=fd8800f0ecaea5dfc01658450b4a37e794dab25a;hb=ec8f3cedf60fb1feed6d34de6b49f6bfa78b9dd8;hp=b22b9c7156c0ae63734de8dfe2f1068532c92f3c;hpb=056dad85a910551cc95e44d451a61f6b8c4dd35d;p=jalview.git diff --git a/src/jalview/ext/ensembl/EnsemblSeqProxy.java b/src/jalview/ext/ensembl/EnsemblSeqProxy.java index b22b9c7..fd8800f 100644 --- a/src/jalview/ext/ensembl/EnsemblSeqProxy.java +++ b/src/jalview/ext/ensembl/EnsemblSeqProxy.java @@ -20,6 +20,17 @@ */ package jalview.ext.ensembl; +import java.io.IOException; +import java.net.MalformedURLException; +import java.net.URL; +import java.util.ArrayList; +import java.util.Arrays; +import java.util.Collections; +import java.util.List; +import java.util.Map; + +import org.json.simple.parser.ParseException; + import jalview.analysis.AlignmentUtils; import jalview.analysis.Dna; import jalview.bin.Cache; @@ -41,19 +52,6 @@ import jalview.util.DBRefUtils; import jalview.util.IntRangeComparator; import jalview.util.MapList; -import java.io.BufferedReader; -import java.io.IOException; -import java.net.MalformedURLException; -import java.net.URL; -import java.util.ArrayList; -import java.util.Arrays; -import java.util.Collections; -import java.util.List; - -import org.json.simple.JSONObject; -import org.json.simple.parser.JSONParser; -import org.json.simple.parser.ParseException; - /** * Base class for Ensembl sequence fetchers * @@ -172,14 +170,15 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient * fetch and transfer genomic sequence features, * fetch protein product and add as cross-reference */ - for (String accId : allIds) + for (int i = 0, n = allIds.size(); i < n; i++) { - addFeaturesAndProduct(accId, alignment); + addFeaturesAndProduct(allIds.get(i), alignment); } - for (SequenceI seq : alignment.getSequences()) + List seqs = alignment.getSequences(); + for (int i = 0, n = seqs.size(); i < n; i++) { - getCrossReferences(seq); + getCrossReferences(seqs.get(i)); } return alignment; @@ -209,13 +208,19 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient */ SequenceI genomicSequence = null; EnsemblFeatures gffFetcher = new EnsemblFeatures(getDomain()); - EnsemblFeatureType[] features = getFeaturesToFetch(); + EnsemblFeatureType[] features = getFeaturesToFetch(); + + // Platform.timeCheck("ESP.getsequencerec1", Platform.TIME_MARK); + AlignmentI geneFeatures = gffFetcher.getSequenceRecords(accId, features); if (geneFeatures != null && geneFeatures.getHeight() > 0) { genomicSequence = geneFeatures.getSequenceAt(0); } + + // Platform.timeCheck("ESP.getsequencerec2", Platform.TIME_MARK); + if (genomicSequence != null) { /* @@ -229,6 +234,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient * fetch and map protein product, and add it as a cross-reference * of the retrieved sequence */ + // Platform.timeCheck("ESP.transferFeatures", Platform.TIME_MARK); addProteinProduct(querySeq); } } @@ -237,6 +243,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient System.err.println( "Error transferring Ensembl features: " + e.getMessage()); } + // Platform.timeCheck("ESP.addfeat done", Platform.TIME_MARK); } /** @@ -258,6 +265,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient String accId = querySeq.getName(); try { + System.out.println("Adding protein product for " + accId); AlignmentI protein = new EnsemblProtein(getDomain()) .getSequenceRecords(accId); if (protein == null || protein.getHeight() == 0) @@ -284,10 +292,10 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient DBRefEntry dbr = new DBRefEntry(getDbSource(), getEnsemblDataVersion(), proteinSeq.getName(), map); querySeq.getDatasetSequence().addDBRef(dbr); - DBRefEntry[] uprots = DBRefUtils.selectRefs(ds.getDBRefs(), + List uprots = DBRefUtils.selectRefs(ds.getDBRefs(), new String[] { DBRefSource.UNIPROT }); - DBRefEntry[] upxrefs = DBRefUtils.selectRefs(querySeq.getDBRefs(), + List upxrefs = DBRefUtils.selectRefs(querySeq.getDBRefs(), new String[] { DBRefSource.UNIPROT }); if (uprots != null) @@ -348,25 +356,46 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient */ protected void getCrossReferences(SequenceI seq) { + + // Platform.timeCheck("ESP. getdataseq ", Platform.TIME_MARK); + + while (seq.getDatasetSequence() != null) { seq = seq.getDatasetSequence(); } + // Platform.timeCheck("ESP. getxref ", Platform.TIME_MARK); + EnsemblXref xrefFetcher = new EnsemblXref(getDomain(), getDbSource(), getEnsemblDataVersion()); List xrefs = xrefFetcher.getCrossReferences(seq.getName()); - for (DBRefEntry xref : xrefs) + + for (int i = 0, n = xrefs.size(); i < n; i++) { - seq.addDBRef(xref); +// Platform.timeCheck("ESP. getxref + " + (i) + "/" + n, Platform.TIME_MARK); + // BH 2019.01.25 this next method was taking 174 ms PER addition for a 266-reference example. + // DBRefUtils.ensurePrimaries(seq) + // was at the end of seq.addDBRef, so executed after ever addition! + // This method was moved to seq.getPrimaryDBRefs() + seq.addDBRef(xrefs.get(i)); } +// System.out.println("primaries are " + seq.getPrimaryDBRefs().toString()); /* * and add a reference to itself */ + +// Platform.timeCheck("ESP. getxref self ", Platform.TIME_MARK); + DBRefEntry self = new DBRefEntry(getDbSource(), getEnsemblDataVersion(), - seq.getName()); + seq.getName()); + +// Platform.timeCheck("ESP. getxref self add ", Platform.TIME_MARK); + seq.addDBRef(self); + + // Platform.timeCheck("ESP. seqprox done ", Platform.TIME_MARK); } /** @@ -387,13 +416,11 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient inProgress = false; throw new JalviewException("ENSEMBL Rest API not available."); } - BufferedReader br = getSequenceReader(ids); - if (br == null) - { - return alignment; - } + // Platform.timeCheck("EnsemblSeqProx.fetchSeq ", Platform.TIME_MARK); - List seqs = parseSequenceJson(br); + List seqs = parseSequenceJson(ids); + if (seqs == null) + return alignment; if (seqs.isEmpty()) { @@ -446,9 +473,9 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient * @return a single jalview.datamodel.Sequence * @see http://rest.ensembl.org/documentation/info/sequence_id */ - protected List parseSequenceJson(BufferedReader br) + @SuppressWarnings("unchecked") + protected List parseSequenceJson(List ids) { - JSONParser jp = new JSONParser(); List result = new ArrayList<>(); try { @@ -456,7 +483,10 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient * for now, assumes only one sequence returned; refactor if needed * in future to handle a JSONArray with more than one */ - final JSONObject val = (JSONObject) jp.parse(br); + // Platform.timeCheck("ENS seqproxy", Platform.TIME_MARK); + Map val = (Map) getJSON(null, ids, -1, MODE_MAP, null); + if (val == null) + return null; Object s = val.get("desc"); String desc = s == null ? null : s.toString(); s = val.get("id"); @@ -479,6 +509,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient System.err.println("Error processing JSON response: " + e.toString()); // ignore } + // Platform.timeCheck("ENS seqproxy2", Platform.TIME_MARK); return result; } @@ -504,7 +535,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient // @see https://github.com/Ensembl/ensembl-rest/wiki/Output-formats urlstring.append("?type=").append(getSourceEnsemblType().getType()); urlstring.append(("&Accept=application/json")); - urlstring.append(("&Content-Type=application/json")); + urlstring.append(("&content-type=application/json")); String objectType = getObjectType(); if (objectType != null) @@ -658,7 +689,9 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient */ protected abstract List getIdentifyingFeatures( SequenceI seq, String accId); - + + int bhtest = 0; + /** * Transfers the sequence feature to the target sequence, locating its start * and end range based on the mapping. Features which do not overlap the @@ -680,6 +713,7 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient if (mappedRange != null) { +// Platform.timeCheck(null, Platform.TIME_SET); String group = sf.getFeatureGroup(); if (".".equals(group)) { @@ -687,8 +721,11 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient } int newBegin = Math.min(mappedRange[0], mappedRange[1]); int newEnd = Math.max(mappedRange[0], mappedRange[1]); - SequenceFeature copy = new SequenceFeature(sf, newBegin, newEnd, - group, sf.getScore()); +// Platform.timeCheck(null, Platform.TIME_MARK); + bhtest++; + // 280 ms/1000 here: + SequenceFeature copy = new SequenceFeature(sf, newBegin, newEnd, group, sf.getScore()); + // 0.175 ms here: targetSequence.addSequenceFeature(copy); /* @@ -781,10 +818,12 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient MapList mapping = getGenomicRangesFromFeatures(sourceSequence, accessionId, targetSequence.getStart()); if (mapping == null) - { + { return false; } + // Platform.timeCheck("ESP. xfer " + sfs.size(), Platform.TIME_MARK); + boolean result = transferFeatures(sfs, targetSequence, mapping, accessionId); // System.out.println("transferFeatures (" + (sfs.size()) + " --> " @@ -818,14 +857,23 @@ public abstract class EnsemblSeqProxy extends EnsemblRestClient SequenceFeatures.sortFeatures(sfs, forwardStrand); boolean transferred = false; - for (SequenceFeature sf : sfs) + + for (int i = 0, n = sfs.size(); i < n; i++) { + +// if ((i%1000) == 0) { +//// Platform.timeCheck("Feature " + bhtest, Platform.TIME_GET); +// Platform.timeCheck("ESP. xferFeature + " + (i) + "/" + n, Platform.TIME_MARK); +// } + + SequenceFeature sf = sfs.get(i); if (retainFeature(sf, parentId)) { transferFeature(sf, targetSequence, mapping, forwardStrand); transferred = true; } } + return transferred; }