- <strong>Configuration</strong><br/>
- The default mapping method can be configured via <strong>Tools → Preferences →
- Structure tab</strong> Then scroll to the 'Sequence ↔ Structure method' section of
- the dialog box and change the default method. When 'SIFTS' is enabled as the default, all
- mappings between 'Sequence ↔ Structure' is performed via SIFTS provided that there
- is a valid SIFTS resource for the PDB entry. If no valid SIFTS resource is available, then
- the 'Sequence ↔ Structure' mapping falls back to Needleman and Wunsch Alignment algorithm.
- </p>
-
- <p><strong>Multi-Chain Mappings</strong>
- <br/>One of the main merits of SIFTS is the ability to accurately achieve multi-chain mapping
- (one-to-many) between a single Uniprot sequence and its corresponding multiple chains in
- PDB. Consequently, mousing over the uniprot sequence in the alignment window results
- to highlighting multiple corresponding positions in the structure viewer for the mapped chains.
+ <strong>Multi-Chain Mappings</strong> <br />SIFTS gives Jalview the
+ ability to display multi-chain mappings between UniProt sequences
+ and PDB structure data. This is important when working with
+ multimeric proteins, since the biological unit will contain several
+ structures for the same protein sequence. Multi-chain mapping allows
+ all residues in a structure to be located in the alignment, and
+ also, when shading the structure by sequence colours, enables
+ conservation patterns between oligomer interfaces to be explored.