2 # This matrix was created by Todd Lowe 12/10/92
4 # Uses ambiguous nucleotide codes, probabilities rounded to
7 # Lowest score = -4, Highest score = 5
9 A T G C S W R Y K M B V H D N
10 A 5 -4 -4 -4 -4 1 1 -4 -4 1 -4 -1 -1 -1 -2
11 T -4 5 -4 -4 -4 1 -4 1 1 -4 -1 -4 -1 -1 -2
12 G -4 -4 5 -4 1 -4 1 -4 1 -4 -1 -1 -4 -1 -2
13 C -4 -4 -4 5 1 -4 -4 1 -4 1 -1 -1 -1 -4 -2
14 S -4 -4 1 1 -1 -4 -2 -2 -2 -2 -1 -1 -3 -3 -1
15 W 1 1 -4 -4 -4 -1 -2 -2 -2 -2 -3 -3 -1 -1 -1
16 R 1 -4 1 -4 -2 -2 -1 -4 -2 -2 -3 -1 -3 -1 -1
17 Y -4 1 -4 1 -2 -2 -4 -1 -2 -2 -1 -3 -1 -3 -1
18 K -4 1 1 -4 -2 -2 -2 -2 -1 -4 -1 -3 -3 -1 -1
19 M 1 -4 -4 1 -2 -2 -2 -2 -4 -1 -3 -1 -1 -3 -1
20 B -4 -1 -1 -1 -1 -3 -3 -1 -1 -3 -1 -2 -2 -2 -1
21 V -1 -4 -1 -1 -1 -3 -1 -3 -3 -1 -2 -1 -2 -2 -1
22 H -1 -1 -4 -1 -3 -1 -3 -1 -3 -1 -2 -2 -1 -2 -1
23 D -1 -1 -1 -4 -3 -1 -1 -3 -1 -3 -2 -2 -2 -1 -1
24 N -2 -2 -2 -2 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1