2 char *amino_acid_order = "ABCDEFGHIKLMNPQRSTVWXYZ";
4 //Jones Taylor Thornton, tm matrix,
6 //D The 250 PAM transmembrane protein exchange matrix (Jones et al., 1994)
7 //R LIT:2006072 PMID:8112466
8 //A Jones, D.T., Taylor, W.R. and Thornton, J.M.
9 //T A mutation data matrix for transmembrane proteins
10 //J FEBS Lett. 339, 269-275 (1994)
18 1, 0, -1, 3, 3, -4, 6,
19 -3, 0, -1, 3, 2, -3, -3, 11,
20 0, 0, -1, -3, -4, -1, -2, -4, 2,
21 -2, 0, -3, 3, 1, -5, -1, 4, -4, 12,
22 -2, 0, -1, -5, -5, 1, -4, -4, 1, -4, 3,
23 -1, 0, -1, -3, -3, 0, -3, -3, 1, -1, 1, 3,
24 -1, 0, -1, 6, 1, -4, -2, 3, -3, 5, -4, -2, 11,
25 0, 0, -4, -2, -3, -4, -2, -4, -3, -4, -1, -3, -2, 11,
26 -2, 0, -3, 2, 7, -4, -1, 7, -4, 6, -2, -2, 3, 0, 11,
27 -1, 0, -1, 1, 2, -4, 0, 5, -3, 9, -3, 0, 2, -3, 6, 7,
28 2, 0, 1, 0, 0, -1, 1, -2, -1, -1, -2, -2, 2, -1, -1, -1, 3,
29 1, 0, 0, 0, -1, -2, 0, -2, 0, -2, -1, 0, 1, -1, -2, -1, 2, 3,
30 0, 0, 0, -3, -2, -1, -1, -4, 2, -4, 0, 1, -3, -3, -4, -2, -1, 0, 2,
31 -4, 0, 1, -4, -3, -3, -2, -1, -3, 3, -2, -2, -3, -6, 0, 5, -3, -4, -2, 12,
32 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
33 -3, 0, 3, -2, -5, 2, -5, 6, -4, 1, -3, -3, -1, -5, 0, -1, 0, -3, -4, -2, 0, 10,
34 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0};
43 -2, -3, -3, -5, -4, 10,
44 0, 0, -4, -1, -2, -3, 8,
45 -2, -2, -5, -2, 0, -3, -3, 14,
46 0, -2, -2, -4, -3, 0, -1, -2, 6,
47 0, 0, -3, 0, 2, -1, -1, -2, -2, 4,
48 -1, -1, 0, -1, -1, 2, -2, -1, 2, -2, 4,
49 1, -2, -2, -3, -1, -2, -2, 2, 1, 2, 2, 6,
50 0, 4, -1, 1, -1, -1, 0, -1, 0, 0, -2, 0, 8,
51 -1, -2, -3, -1, 1, -4, -1, 1, -3, 1, -3, -4, -3, 11,
52 1, -1, -2, -1, 2, -3, -2, 0, -2, 0, -2, -1, -1, 0, 8,
53 -1, -2, -2, -1, -1, -1, -2, -1, -3, 1, -2, 0, -2, -1, 3, 8,
54 1, 0, -2, 0, 0, -1, 0, -1, -1, 0, -2, -2, 0, -1, -1, -1, 4,
55 1, 0, -2, -1, -2, -2, -2, -2, 0, -1, 0, 0, 1, 0, 0, -3, 2, 5,
56 1, -2, -2, -2, -3, 1, -3, -3, 4, -2, 1, 0, -2, -4, -3, -1, -1, 1, 5,
57 -5, -5, -2, -4, -1, 1, 1, -5, -3, -2, -2, -3, -7, -3, -1, 0, -3, -5, -3, 20,
58 0, -1, -2, -1, -1, -1, -1, -1, 0, 0, 0, 0, 0, -1, 0, -1, 0, 0, 0, -2, -1,
59 -4, -3, -6, -1, -2, 3, -3, 0, -1, -1, 3, -1, -4, -2, -1, 0, -2, -1, 1, 5, -1, 9,
60 0, 0, 0, 0, 5, -4, -2, 0, -3, 1, -1, -1, -1, 0, 4, 0, -1, -1, -3, -1, 0, -2, 4};
68 -3, -3, -2, -4, -3, 9,
69 1, -1, -3, -2, -3, -3, 8,
70 -2, 0, -4, 0, 0, -2, -2, 13,
71 -1, -3, -4, -4, -4, 1, -4, -3, 6,
72 -1, 0, -3, 0, 1, -3, -2, -1, -3, 6,
73 -2, -3, -2, -3, -2, 2, -4, -2, 2, -2, 6,
74 -1, -3, -3, -3, -2, 0, -2, 1, 1, -1, 3, 7,
75 -1, 4, -2, 2, -1, -3, 0, 1, -2, 0, -3, -2, 8,
76 -2, -2, -5, -2, 0, -4, -1, -2, -2, -1, -4, -2, -2, 11,
77 0, 0, -4, -1, 2, -4, -2, 0, -3, 1, -2, -1, 1, -2, 8,
78 -2, -1, -3, -1, -1, -2, -3, 0, -3, 3, -2, -1, 0, -3, 2, 9,
79 1, 0, -1, 0, 0, -2, 0, -1, -2, 0, -3, -2, 1, -1, 1, -1, 5,
80 0, 0, -1, -1, -1, -1, -2, -2, -1, 0, -1, -1, 0, 0, -1, -2, 2, 6,
81 0, -3, -2, -3, -3, 0, -4, -4, 4, -2, 2, 1, -3, -3, -3, -2, -1, 1, 5,
82 -3, -4, -6, -5, -2, 1, -2, -5, -3, -2, -1, -2, -4, -4, -1, -2, -5, -4, -3, 19,
83 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, 0, -1, -2, -1, -1, 0, 0, -1, -2, -1,
84 -2, -3, -4, -3, -2, 4, -3, 2, 0, -1, 0, 1, -2, -3, -1, -1, -2, -1, -1, 3, -1, 9,
85 -1, 2, -3, 1, 5, -4, -2, 0, -4, 1, -2, -2, 0, -1, 4, 0, 0, -1, -3, -2, -1, -2, 5};
93 -2, -3, -2, -4, -3, 8,
94 0, -1, -3, -1, -2, -3, 7,
95 -2, 0, -3, 0, 0, -2, -2, 10,
96 -1, -3, -3, -4, -3, 0, -4, -3, 5,
97 -1, 0, -3, 0, 1, -3, -2, -1, -3, 5,
98 -1, -3, -2, -3, -2, 1, -3, -2, 2, -3, 5,
99 -1, -2, -2, -3, -2, 0, -2, 0, 2, -1, 2, 6,
100 -1, 4, -2, 2, 0, -2, 0, 1, -2, 0, -3, -2, 6,
101 -1, -2, -4, -1, 0, -3, -2, -2, -2, -1, -3, -2, -2, 9,
102 -1, 0, -3, 0, 2, -4, -2, 1, -2, 1, -2, 0, 0, -1, 6,
103 -2, -1, -3, -1, 0, -2, -2, 0, -3, 3, -2, -1, 0, -2, 1, 7,
104 1, 0, -1, 0, 0, -2, 0, -1, -2, -1, -3, -2, 1, -1, 0, -1, 4,
105 0, 0, -1, -1, -1, -1, -2, -2, -1, -1, -1, -1, 0, -1, -1, -1, 2, 5,
106 0, -3, -1, -3, -3, 0, -3, -3, 3, -2, 1, 1, -3, -3, -3, -2, -1, 0, 5,
107 -2, -4, -5, -4, -3, 1, -2, -3, -2, -2, -2, -2, -4, -3, -2, -2, -4, -3, -3, 15,
108 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 0, 0, -1, -2, -1,
109 -2, -2, -3, -2, -2, 3, -3, 2, 0, -1, 0, 0, -2, -3, -1, -1, -2, -1, -1, 3, -1, 8,
110 -1, 2, -3, 1, 4, -3, -2, 0, -3, 1, -2, -1, 0, -1, 4, 0, 0, -1, -3, -2, -1, -2, 4};
118 -3, -4, -2, -5, -3, 8,
119 0, -1, -3, -1, -3, -4, 8,
120 -2, 0, -3, -1, 0, -1, -2, 10,
121 -1, -4, -2, -4, -4, 0, -4, -4, 5,
122 -1, 0, -3, -1, 1, -4, -2, 0, -3, 6,
123 -2, -4, -2, -4, -3, 1, -4, -3, 2, -3, 5,
124 -1, -3, -2, -4, -2, 0, -3, -1, 2, -2, 3, 7,
125 -1, 4, -2, 2, 0, -4, 0, 1, -3, 0, -4, -2, 7,
126 -1, -2, -4, -1, -1, -4, -2, -2, -3, -1, -4, -3, -2, 10,
127 -1, 0, -3, 0, 2, -4, -2, 1, -3, 2, -2, 0, 0, -1, 7,
128 -2, -1, -4, -2, 0, -3, -3, 0, -4, 3, -3, -2, -1, -3, 1, 7,
129 1, 0, -1, 0, -1, -3, 0, -1, -3, 0, -3, -2, 1, -1, 0, -1, 5,
130 0, 0, -1, -1, -1, -2, -2, -2, -1, -1, -1, -1, 0, -1, -1, -1, 2, 5,
131 0, -4, -1, -4, -3, -1, -4, -4, 4, -3, 1, 1, -3, -3, -3, -3, -2, 0, 5,
132 -3, -5, -5, -5, -3, 1, -3, -3, -3, -3, -2, -1, -4, -4, -1, -3, -4, -3, -3, 15,
133 -1, -1, -2, -1, -1, -2, -2, -1, -1, -1, -1, -1, -1, -2, -1, -1, -1, 0, -1, -3, -1,
134 -2, -3, -3, -3, -2, 4, -3, 2, -1, -2, -1, 0, -2, -3, -1, -1, -2, -2, -1, 2, -1, 8,
135 -1, 2, -3, 1, 5, -4, -2, 0, -3, 1, -3, -1, 0, -1, 4, 0, 0, -1, -3, -2, -1, -2, 5};
144 -3, -5, -3, -5, -4, 9,
145 0, -1, -3, -2, -3, -4, 8,
146 -2, 0, -4, -1, -1, -1, -2, 11,
147 -2, -4, -2, -4, -4, 0, -5, -4, 6,
148 -1, 0, -4, -1, 1, -4, -2, 0, -4, 6,
149 -2, -4, -2, -5, -4, 1, -5, -3, 2, -3, 6,
150 -1, -3, -2, -4, -3, 0, -3, -2, 2, -2, 3, 8,
151 -2, 4, -3, 2, 0, -4, 0, 1, -4, 0, -4, -3, 8,
152 -1, -2, -3, -2, -1, -5, -3, -3, -3, -1, -4, -3, -2, 10,
153 -1, 0, -4, 0, 2, -4, -2, 1, -4, 2, -3, 0, 0, -1, 7,
154 -2, -1, -4, -2, 0, -3, -3, 0, -4, 3, -3, -2, -1, -3, 1, 8,
155 2, 0, -1, 0, 0, -3, 0, -1, -3, 0, -3, -2, 1, -1, 0, -1, 5,
156 0, -1, -1, -1, -1, -3, -2, -2, -1, -1, -2, -1, 0, -1, -1, -1, 2, 6,
157 0, -4, -1, -4, -3, -1, -4, -4, 4, -3, 1, 1, -4, -3, -3, -3, -2, 0, 5,
158 -4, -5, -4, -5, -3, 2, -3, -3, -3, -4, -3, -2, -5, -5, -2, -3, -4, -3, -4, 15,
159 -1, -1, -2, -2, -1, -2, -2, -1, -1, -1, -1, -1, -1, -2, -1, -1, -1, -1, -1, -3, -1,
160 -2, -3, -3, -3, -2, 4, -4, 2, -1, -2, -1, -1, -2, -4, -1, -2, -2, -2, -2, 3, -1, 9,
161 -1, 2, -4, 1, 5, -4, -3, 0, -4, 1, -3, -2, 0, -1, 4, 0, 0, -1, -3, -3, -1, -2, 5};
169 -2, -3, -2, -3, -3, 6,
170 0, -1, -3, -1, -2, -3, 6,
171 -2, 0, -3, -1, 0, -1, -2, 8,
172 -1, -3, -1, -3, -3, 0, -4, -3, 4,
173 -1, 0, -3, -1, 1, -3, -2, -1, -3, 5,
174 -1, -4, -1, -4, -3, 0, -4, -3, 2, -2, 4,
175 -1, -3, -1, -3, -2, 0, -3, -2, 1, -1, 2, 5,
176 -2, 3, -3, 1, 0, -3, 0, 1, -3, 0, -3, -2, 6,
177 -1, -2, -3, -1, -1, -4, -2, -2, -3, -1, -3, -2, -2, 7,
178 -1, 0, -3, 0, 2, -3, -2, 0, -3, 1, -2, 0, 0, -1, 5,
179 -1, -1, -3, -2, 0, -3, -2, 0, -3, 2, -2, -1, 0, -2, 1, 5,
180 1, 0, -1, 0, 0, -2, 0, -1, -2, 0, -2, -1, 1, -1, 0, -1, 4,
181 0, -1, -1, -1, -1, -2, -2, -2, -1, -1, -1, -1, 0, -1, -1, -1, 1, 5,
182 0, -3, -1, -3, -2, -1, -3, -3, 3, -2, 1, 1, -3, -2, -2, -3, -2, 0, 4,
183 -3, -4, -2, -4, -3, 1, -2, -2, -3, -3, -2, -1, -4, -4, -2, -3, -3, -2, -3, 11,
184 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, -1, -1, 0, 0, -1, -2, -1,
185 -2, -3, -2, -3, -2, 3, -3, 2, -1, -2, -1, -1, -2, -3, -1, -2, -2, -2, -1, 2, -1, 7,
186 -1, 1, -3, 1, 4, -3, -2, 0, -3, 1, -3, -1, 0, -1, 3, 0, 0, -1, -2, -3, -1, -2, 4};
194 -2, -3, -2, -3, -3, 0,
195 0, -1, -3, -1, -2, -3, 0,
196 -2, 0, -3, -1, 0, -1, -2, 0,
197 -1, -3, -1, -3, -3, 0, -4, -3, 0,
198 -1, 0, -3, -1, 1, -3, -2, -1, -3, 0,
199 -1, -4, -1, -4, -3, 0, -4, -3, 2, -2, 0,
200 -1, -3, -1, -3, -2, 0, -3, -2, 1, -1, 2, 0,
201 -2, 3, -3, 1, 0, -3, 0, 1, -3, 0, -3, -2, 0,
202 -1, -2, -3, -1, -1, -4, -2, -2, -3, -1, -3, -2, -2, 0,
203 -1, 0, -3, 0, 2, -3, -2, 0, -3, 1, -2, 0, 0, -1, 0,
204 -1, -1, -3, -2, 0, -3, -2, 0, -3, 2, -2, -1, 0, -2, 1, 0,
205 1, 0, -1, 0, 0, -2, 0, -1, -2, 0, -2, -1, 1, -1, 0, -1, 0,
206 0, -1, -1, -1, -1, -2, -2, -2, -1, -1, -1, -1, 0, -1, -1, -1, 1, 0,
207 0, -3, -1, -3, -2, -1, -3, -3, 3, -2, 1, 1, -3, -2, -2, -3, -2, 0, 0,
208 -3, -4, -2, -4, -3, 1, -2, -2, -3, -3, -2, -1, -4, -4, -2, -3, -3, -2, -3, 0,
209 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, -1, -1, 0, 0, -1, -2, 0,
210 -2, -3, -2, -3, -2, 3, -3, 2, -1, -2, -1, -1, -2, -3, -1, -2, -2, -2, -1, 2, -1, 0,
211 -1, 1, -3, 1, 4, -3, -2, 0, -3, 1, -3, -1, 0, -1, 3, 0, 0, -1, -2, -3, -1, -2, 0};
219 -2, -3, -2, -3, -3, 3,
220 0, -1, -3, -1, -2, -3, 0,
221 -2, 0, -3, -1, 0, -1, -2, 2,
222 -1, -3, -1, -3, -3, 0, -4, -3, 2,
223 -1, 0, -3, -1, 1, -3, -2, -1, -3, 2,
224 -1, -4, -1, -4, -3, 0, -4, -3, 2, -2, 1,
225 -1, -3, -1, -3, -2, 0, -3, -2, 1, -1, 2, 0,
226 -2, 3, -3, 1, 0, -3, 0, 1, -3, 0, -3, -2, 0,
227 -1, -2, -3, -1, -1, -4, -2, -2, -3, -1, -3, -2, -2, 0,
228 -1, 0, -3, 0, 2, -3, -2, 0, -3, 1, -2, 0, 0, -1, 2,
229 -1, -1, -3, -2, 0, -3, -2, 0, -3, 2, -2, -1, 0, -2, 1, 0,
230 1, 0, -1, 0, 0, -2, 0, -1, -2, 0, -2, -1, 1, -1, 0, -1, 1,
231 0, -1, -1, -1, -1, -2, -2, -2, -1, -1, -1, -1, 0, -1, -1, -1, 1, 1,
232 0, -3, -1, -3, -2, -1, -3, -3, 3, -2, 1, 1, -3, -2, -2, -3, -2, 0, 1,
233 -3, -4, -2, -4, -3, 1, -2, -2, -3, -3, -2, -1, -4, -4, -2, -3, -3, -2, -3, 1,
234 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, -1, -1, 0, 0, -1, -2, -1,
235 -2, -3, -2, -3, -2, 3, -3, 2, -1, -2, -1, -1, -2, -3, -1, -2, -2, -2, -1, 2, -1, 3,
236 -1, 1, -3, 1, 4, -3, -2, 0, -3, 1, -3, -1, 0, -1, 3, 0, 0, -1, -2, -3, -1, -2, 4};
245 -4, -6, -4, -6, -6, 10,
246 0, -2, -6, -3, -4, -6, 9,
247 -3, -1, -7, -2, 0, -2, -4, 12,
248 -3, -6, -2, -7, -6, -1, -7, -6, 7,
249 -1, -1, -6, -2, 1, -5, -3, -1, -5, 8,
250 -3, -7, -3, -7, -6, 0, -7, -5, 2, -4, 6,
251 -2, -5, -3, -6, -4, 0, -5, -4, 2, -3, 3, 9,
252 -3, 5, -5, 2, -1, -6, -1, 1, -6, 0, -6, -4, 9,
253 -1, -4, -6, -3, -2, -6, -5, -4, -5, -2, -5, -4, -4, 12,
254 -2, -1, -5, -1, 3, -5, -4, 1, -5, 2, -4, -1, 0, -3, 9,
255 -3, -2, -6, -3, -1, -5, -4, 0, -5, 3, -4, -3, -1, -3, 1, 9,
256 2, 0, -2, -1, -1, -4, -1, -2, -4, -1, -4, -3, 1, -2, -1, -2, 7,
257 0, -1, -2, -2, -2, -4, -3, -3, -2, -1, -3, -1, 0, -3, -1, -2, 2, 8,
258 -1, -6, -2, -6, -4, -2, -6, -5, 4, -4, 1, 1, -5, -4, -4, -4, -3, 0, 7,
259 -5, -8, -5, -8, -6, 0, -6, -4, -5, -6, -4, -3, -7, -7, -4, -5, -6, -5, -5, 16,
260 -1, -3, -4, -3, -2, -3, -3, -2, -2, -2, -2, -2, -2, -3, -2, -2, -1, -1, -2, -5, -2,
261 -4, -5, -5, -6, -5, 4, -6, 3, -3, -4, -2, -3, -4, -6, -3, -4, -3, -3, -3, 3, -3, 11,
262 -2, 0, -7, 1, 6, -6, -4, 0, -6, 1, -5, -3, -1, -2, 5, 0, -1, -2, -4, -5, -1, -4, 6};
270 -4, -5, -6, -7, -7, 8,
271 1, 0, -4, 0, -1, -5, 5,
272 -3, 1, -4, 0, -1, -3, -4, 7,
273 -1, -3, -3, -3, -3, 0, -4, -4, 6,
274 -2, 0, -7, -1, -1, -7, -3, -2, -3, 5,
275 -3, -4, -7, -5, -4, 0, -5, -3, 1, -4, 5,
276 -2, -4, -6, -4, -3, -1, -4, -4, 1, 0, 3, 8,
277 -1, 3, -5, 2, 1, -4, 0, 2, -2, 1, -4, -3, 4,
278 1, -2, -4, -3, -2, -5, -2, -1, -3, -2, -3, -3, -2, 6,
279 -1, 0, -7, 1, 2, -6, -3, 3, -3, 0, -2, -1, 0, 0, 6,
280 -3, -2, -4, -3, -3, -5, -4, 1, -2, 2, -4, -1, -1, -1, 1, 6,
281 1, 0, 0, 0, -1, -3, 1, -2, -2, -1, -4, -2, 1, 1, -2, -1, 3,
282 1, 0, -3, -1, -2, -4, -1, -3, 0, -1, -3, -1, 0, -1, -2, -2, 2, 4,
283 0, -3, -3, -3, -3, -3, -2, -3, 3, -4, 1, 1, -3, -2, -3, -3, -2, 0, 5,
284 -7, -6, -8, -8, -8, -1, -8, -3, -6, -5, -3, -6, -4, -7, -6, 1, -2, -6, -8, 12,
285 -1, -1, -4, -2, -1, -3, -2, -2, -1, -2, -2, -2, -1, -2, -1, -2, -1, -1, -1, -5, -2,
286 -4, -3, -1, -5, -5, 4, -6, -1, -2, -5, -2, -4, -2, -6, -5, -5, -3, -3, -3, -2, -3, 8,
287 -1, 2, -7, 3, 4, -6, -2, 1, -3, -1, -3, -2, 0, -1, 4, -1, -1, -2, -3, -7, -1, -5, 4};
295 -3, -4, -5, -6, -5, 7,
296 1, 0, -3, 0, 0, -4, 4,
297 -2, 1, -3, 0, 0, -2, -3, 6,
298 -1, -2, -2, -3, -2, 0, -3, -3, 5,
299 -2, 0, -5, 0, -1, -5, -2, -1, -2, 4,
300 -2, -4, -6, -4, -3, 1, -4, -2, 2, -3, 5,
301 -1, -3, -5, -3, -2, 0, -3, -3, 2, 0, 3, 7,
302 0, 2, -4, 2, 1, -3, 0, 2, -2, 1, -3, -2, 3,
303 1, -1, -3, -2, -1, -4, -1, -1, -2, -2, -3, -2, -1, 5,
304 -1, 1, -5, 1, 2, -5, -2, 2, -2, 0, -2, -1, 0, 0, 5,
305 -2, -1, -3, -2, -2, -4, -3, 1, -2, 3, -3, -1, -1, -1, 1, 6,
306 1, 0, 0, 0, 0, -3, 1, -1, -2, -1, -3, -2, 1, 1, -1, -1, 2,
307 1, 0, -2, -1, -1, -3, -1, -2, 0, 0, -2, -1, 0, 0, -1, -1, 1, 3,
308 0, -2, -2, -3, -2, -2, -2, -2, 3, -3, 1, 1, -2, -2, -2, -3, -1, 0, 4,
309 -5, -5, -7, -6, -7, -1, -7, -3, -5, -4, -2, -4, -4, -5, -5, 1, -2, -5, -6, 12,
310 0, -1, -3, -1, -1, -3, -1, -1, -1, -1, -2, -1, 0, -1, -1, -1, 0, 0, -1, -4, -1,
311 -3, -3, 0, -4, -4, 5, -5, 0, -2, -4, -2, -3, -2, -5, -4, -4, -3, -3, -3, -1, -3, 8,
312 0, 2, -5, 2, 3, -5, -1, 1, -2, 0, -3, -2, 1, -1, 3, 0, -1, -1, -2, -6, -1, -4, 3};
320 -3, -4, -4, -6, -5, 9,
321 1, 0, -3, 1, 0, -5, 5,
322 -1, 1, -3, 1, 1, -2, -2, 6,
323 -1, -2, -2, -2, -2, 1, -3, -2, 5,
324 -1, 1, -5, 0, 0, -5, -2, 0, -2, 5,
325 -2, -3, -6, -4, -3, 2, -4, -2, 2, -3, 6,
326 -1, -2, -5, -3, -2, 0, -3, -2, 2, 0, 4, 6,
327 0, 2, -4, 2, 1, -3, 0, 2, -2, 1, -3, -2, 2,
328 1, -1, -3, -1, -1, -5, 0, 0, -2, -1, -3, -2, 0, 6,
329 0, 1, -5, 2, 2, -5, -1, 3, -2, 1, -2, -1, 1, 0, 4,
330 -2, -1, -4, -1, -1, -4, -3, 2, -2, 3, -3, 0, 0, 0, 1, 6,
331 1, 0, 0, 0, 0, -3, 1, -1, -1, 0, -3, -2, 1, 1, -1, 0, 2,
332 1, 0, -2, 0, 0, -3, 0, -1, 0, 0, -2, -1, 0, 0, -1, -1, 1, 3,
333 0, -2, -2, -2, -2, -1, -1, -2, 4, -2, 2, 2, -2, -1, -2, -2, -1, 0, 4,
334 -6, -5, -8, -7, -7, 0, -7, -3, -5, -3, -2, -4, -4, -6, -5, 2, -2, -5, -6, 17,
335 0, -1, -3, -1, -1, -2, -1, -1, -1, -1, -1, -1, 0, -1, -1, -1, 0, 0, -1, -4, -1,
336 -3, -3, 0, -4, -4, 7, -5, 0, -1, -4, -1, -2, -2, -5, -4, -4, -3, -3, -2, 0, -2, 10,
337 0, 2, -5, 3, 3, -5, 0, 2, -2, 0, -3, -2, 1, 0, 3, 0, 0, -1, -2, -6, -1, -4, 3};
345 -4, -5, -5, -6, -6, 13,
346 2, 1, -4, 1, 1, -6, 5,
347 -1, 1, -4, 1, 1, -2, -2, 7,
348 0, -2, -3, -2, -2, 2, -2, -2, 5,
349 -1, 1, -6, 1, 0, -6, -1, 1, -2, 5,
350 -2, -4, -7, -4, -4, 3, -4, -2, 4, -3, 8,
351 -1, -2, -6, -3, -2, 1, -3, -2, 3, 0, 5, 6,
352 0, 2, -4, 2, 2, -4, 1, 2, -2, 1, -3, -2, 2,
353 1, 0, -3, 0, 0, -5, 0, 0, -2, -1, -3, -2, 0, 6,
354 0, 2, -6, 2, 3, -5, -1, 3, -2, 1, -2, -1, 1, 1, 4,
355 -1, 0, -4, -1, 0, -5, -2, 2, -2, 4, -3, 0, 1, 0, 2, 7,
356 1, 1, 0, 1, 0, -4, 1, -1, -1, 0, -3, -2, 1, 1, 0, 0, 1,
357 1, 0, -2, 0, 0, -3, 1, -1, 0, 0, -2, -1, 1, 1, 0, -1, 1, 2,
358 0, -2, -2, -2, -2, -1, -1, -2, 4, -2, 3, 2, -2, -1, -2, -3, -1, 0, 5,
359 -7, -6,-10, -8, -8, 1, -8, -3, -6, -4, -2, -5, -5, -7, -5, 4, -3, -6, -7, 27,
360 0, 0, -3, -1, 0, -2, -1, 0, 0, -1, -1, 0, 0, 0, 0, -1, 0, 0, 0, -5, -1,
361 -4, -4, 1, -5, -5, 11, -6, 0, 0, -5, 0, -2, -3, -6, -5, -5, -3, -3, -2, 1, -2, 14,
362 0, 2, -6, 3, 3, -6, 0, 2, -2, 1, -3, -2, 2, 0, 3, 1, 0, 0, -2, -7, 0, -5, 3};
370 -11, 0, -5,-15,-16, 13,
371 -3, 0, -7, -4, -4,-15, 10,
372 -9, 0, -6, -4, -8, -7,-10, 14,
373 -6, 0,-11,-12,-12, -5,-13,-11, 11,
374 -8, 0,-12, -8, -3,-16, -9, -6,-11, 11,
375 -9, 0,-10,-14,-13, -1,-14, -7, -1,-12, 9,
376 -6, 0, -9,-12,-11, -7,-12, -9, 1, -7, 1, 14,
377 -6, 0, -8, 1, -5,-12, -5, 0, -8, -1,-12, -9, 12,
378 -2, 0,-11,-11,-11,-11, -9, -4,-11,-10, -5,-10, -9, 12,
379 -7, 0,-12, -6, 0,-14, -9, 2,-12, -1, -6, -8, -5, -3, 12,
380 -7, 0, -5,-10, -8,-15, -4, 0,-10, 3, -9, -8, -6, -6, 0, 11,
381 0, 0, -2, -6, -8, -6, -2, -6, -8, -7, -7, -8, 1, -1, -7, -5, 9,
382 1, 0, -7, -8, -8,-11, -7, -7, -2, -5, -9, -2, -2, -4, -7, -6, 1, 10,
383 -1, 0, -7, -9, -8, -6, -8,-12, 4,-12, -2, 0,-10, -9,-11,-11, -7, -4, 10,
384 -14, 0, -4,-15,-15, -7, -7,-13,-13,-13, -8,-11,-14,-14,-11, -4, -9,-12,-10, 18,
385 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
386 -13, 0, -2, -8,-14, 2,-13, 2, -9,-13, -9,-11, -6,-13, -9,-10, -7,-10,-11, -6, 0, 14,
387 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0};
395 -6, 0, -2, -9,-10, 11,
396 0, 0, -3, 0, -1, -9, 8,
397 -4, 0, -2, -1, -3, -2, -4, 11,
398 -1, 0, -5, -7, -7, -1, -6, -6, 7,
399 -4, 0, -6, -2, 0, -9, -4, -1, -6, 8,
400 -4, 0, -5, -8, -8, 2, -8, -4, 2, -6, 7,
401 -2, 0, -5, -7, -6, -2, -6, -5, 3, -4, 3, 10,
402 -1, 0, -3, 3, -1, -6, -1, 2, -4, 1, -6, -5, 8,
403 0, 0, -5, -5, -5, -5, -4, -1, -5, -4, -2, -5, -3, 9,
404 -3, 0, -6, -1, 2, -7, -4, 4, -6, 2, -3, -4, -1, 0, 9,
405 -3, 0, -2, -4, -3, -8, -1, 2, -6, 4, -5, -4, -2, -2, 2, 8,
406 2, 0, 0, -2, -3, -3, 0, -2, -3, -3, -3, -3, 2, 1, -3, -2, 5,
407 2, 0, -3, -3, -4, -6, -2, -3, 0, -2, -4, 0, 1, 0, -3, -3, 2, 6,
408 1, 0, -3, -5, -5, -2, -4, -6, 5, -6, 1, 2, -5, -4, -6, -6, -3, 0, 7,
409 -8, 0, 0, -9, -9, -3, -3, -6, -7, -6, -4, -6, -8, -8, -6, -1, -5, -7, -6, 17,
410 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
411 -7, 0, 2, -4, -7, 5, -8, 4, -5, -7, -4, -6, -2, -7, -4, -5, -3, -6, -6, -2, 0, 12,
412 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0};
421 1, 0, -1, 1, 1, -5, 5,
422 -2, 0, 0, 0, 0, 0, -2, 6,
423 0, 0, -2, -3, -3, 0, -3, -3, 4,
424 -1, 0, -3, 0, 1, -5, -1, 1, -3, 5,
425 -1, 0, -2, -4, -4, 2, -4, -2, 2, -3, 5,
426 0, 0, -2, -3, -3, 0, -3, -2, 3, -2, 3, 6,
427 0, 0, -1, 2, 1, -3, 0, 1, -2, 1, -3, -2, 3,
428 1, 0, -2, -2, -2, -2, -1, 0, -2, -1, 0, -2, -1, 6,
429 -1, 0, -3, 0, 2, -4, -1, 3, -3, 2, -2, -2, 0, 0, 5,
430 -1, 0, -1, -1, 0, -4, 0, 2, -3, 4, -3, -2, 0, -1, 2, 5,
431 1, 0, 1, 0, -1, -2, 1, -1, -1, -1, -2, -1, 1, 1, -1, -1, 2,
432 2, 0, -1, -1, -1, -2, 0, -1, 1, -1, -1, 0, 1, 1, -1, -1, 1, 2,
433 1, 0, -2, -3, -2, 0, -2, -3, 4, -3, 2, 2, -2, -1, -3, -3, -1, 0, 4,
434 -4, 0, 1, -5, -5, -1, -1, -3, -4, -3, -2, -3, -4, -4, -3, 0, -3, -4, -3, 15,
435 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
436 -3, 0, 2, -2, -4, 5, -4, 4, -2, -3, -1, -3, -1, -3, -2, -2, -1, -3, -3, 0, 0, 9,
437 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0};
446 1, 0, 0, 1, 1, -3, 4,
447 -1, 0, 0, 0, 0, 0, -1, 3,
448 0, 0, -1, -2, -2, 1, -2, -2, 3,
449 -1, 0, -1, 0, 1, -3, 0, 1, -2, 3,
450 -1, 0, -1, -3, -3, 2, -2, -1, 2, -2, 3,
451 0, 0, -1, -2, -2, 1, -2, -1, 2, -2, 2, 3,
452 0, 0, -1, 1, 1, -2, 0, 1, -1, 1, -2, -1, 2,
453 1, 0, -1, -1, -1, -2, -1, 0, -1, -1, 0, -1, 0, 4,
454 -1, 0, -2, 1, 1, -2, 0, 2, -2, 2, -1, -1, 0, 0, 3,
455 -1, 0, 0, 0, 0, -3, 0, 1, -2, 3, -2, -1, 0, 0, 2, 3,
456 1, 0, 0, 0, 0, -1, 1, 0, -1, 0, -1, -1, 1, 1, 0, 0, 1,
457 1, 0, 0, 0, -1, -1, 0, -1, 0, 0, -1, 0, 0, 1, -1, 0, 1, 1,
458 0, 0, -1, -2, -2, 0, -1, -2, 2, -2, 1, 2, -1, -1, -2, -2, 0, 0, 2,
459 -3, 0, 1, -4, -3, 0, -1, -2, -3, -2, -1, -2, -3, -3, -2, 0, -2, -3, -2, 14,
460 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
461 -2, 0, 2, -2, -2, 5, -3, 3, -1, -2, 0, -1, -1, -2, -1, -1, -1, -2, -2, 0, 0, 7,
462 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0};
471 0, 0, 0, 0, 0, 0, 10,
472 0, 0, 0, 0, 0, 0, 0, 10,
473 0, 0, 0, 0, 0, 0, 0, 0, 10,
474 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
475 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
476 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
477 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
478 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
479 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
480 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
481 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
482 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 10,
483 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,10,
484 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,10,
485 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,10,
486 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,10,
487 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,10};
495 -1, -1, -1, -1, -1, 10,
496 -1, -1, -1, -1, -1, -1, 10,
497 -1, -1, -1, -1, -1, -1, -1, 10,
498 -1, -1, -1, -1, -1, -1, -1, -1, 10,
499 -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
500 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
501 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
502 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
503 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
504 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
505 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
506 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
507 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, 10,
508 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1,10,
509 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1,10,
510 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1,10,
511 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1,10,
512 -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1,10};
519 -10, -10, -10, -10, 10,
520 -10, -10, -10, -10, -10, 10,
521 -10, -10, -10, -10, -10, -10, 10,
522 -10, -10, -10, -10, -10, -10, -10, 10,
523 -10, -10, -10, -10, -10, -10, -10, -10, 10,
524 -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
525 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
526 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
527 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
528 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
529 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
530 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
531 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
532 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, 10,
533 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10,10,
534 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10,10,
535 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10,10,
536 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10,10,
537 -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10, -10,10};
539 /*These are the three structure specific matrices descibed by Luthy, R., McLachlan, A.D. and Eisenberg, D.
540 in Proteins 10, 229-239 (1991), taken from http://www.genome.ad.jp/dbget/dbget2.html
551 -15, 0, 3, -11, -4, 83,
552 1, 0, 4, -15, -4, 2, 41,
553 5, 0, 4, 108, -6, -13, -3, 55,
554 27, 0, -11, 3, -2, -14, 0, -1, 49,
555 -9, 0, 3, 4, -21, -2, -3, -4, -7, 38,
556 -5, 0, 14, 7, -5, 2, 2, -6, -3, 1, 48,
557 -9, 0, 3, 4, -6, -16, -23, -9, -7, -1, 7, 52,
558 28, 0, 1, 2, 27, 7, -5, -9, -9, 108, -15, 3, 10,
559 108, 0, 8, 14, 41, 0, -2, -4, -10, -3, 1, -15, 4, 58,
560 10, 0, 3, -9, 3, -4, 3, 3, 8, 6, -15, 15, 5, -6, 14,
561 1, 0, 10, 3, 1, 108, 5, 27, -5, -9, -9, -15, 2, 3, 2, 28,
562 3, 0, -15, 3, -3, -8, -12, -5, -6, -9, -19, -14, 4, 4, -2, 7, 19,
563 7, 0, 6, 3, 0, -7, 55, -18, -8, -7, 6, -20, -11, 2, -5, 4, 3, 31,
564 -11, 0, -6, -15, -23, -6, -4, -3, 19, -15, -6, -22, 3, -11, -4, 14, -1, -7, 37,
565 4, 0, 15, 3, 2, -8, -1, -12, -22, -2, 5, -19, 14, 4, -21, 4, 0, -9, -1, 129,
566 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
567 4, 0, -4, 8, -3, -30, -6, 49, -10, -7, -12, -18, 3, 3, -6, -11, 3, 2, 2, -5, 0, 59,
568 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 };
577 3, 0, 5, -4, 2, 4, 37,
578 7, 0, 6, 51, 3, 5, -6, 52,
579 28, 0, 1, 1, 6, -21, 2, -6, 38,
580 1, 0, 0, 5, 4, -2, 3, -7, -10, 34,
581 4, 0, 11, 5, 4, 3, 5, -6, -19, -6, 45,
582 1, 0, 4, 6, 3, -23, -5, -12, -14, -4, 9, 40,
583 19, 0, 3, 0, 28, 5, 4, 1, 1, 51, -4, 1, 13,
584 51, 0, 10, 11, 37, 1, 1, -6, -8, -5, 2, -22, 5, 59,
585 13, 0, 1, 1, 0, 2, 4, 5, 10, 7, -5, 23, 7, 3, 11,
586 -1, 0, 13, 5, 3, 51, 7, 28, 4, 1, 1, -4, 1, 1, 0, 19,
587 1, 0, -5, 0, -6, 2, -1, -10, -14, -9, -6, -22, 6, 3, 6, 5, 17,
588 5, 0, 7, 4, 2, 3, 52, -8, -18, 3, 4, -24, 1, 4, 4, 5, 2, 14,
589 1, 0, 3, -5, -5, 5, -7, -19, 7, -6, -2, -28, 4, 7, 3, 11, 2, -38, 40,
590 5, 0, 23, 5, 5, 5, -6, -9, -19, -2, 3, -4, 11, 5, 4, 6, 2, -43, -8, 162,
591 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
592 6, 0, 2, 10, 3, -2, -6, 38, -14, -7, -1, -19, 0, 5, 3, 1, 4, -29, -6, -19, 0, 97,
593 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 };
601 -16, 0, 8, -11, 6, 57,
602 2, 0, 7, -16, 12, 8, 54,
603 13, 0, 9, 97, 2, -30, -4, 55,
604 49, 0, -11, 0, 0, -22, 2, -7, 28,
605 -19, 0, 0, 7, -18, 2, 17, -12, -10, 34,
606 -5, 0, 31, 9, 1, 7, 13, -9, -7, -3, 34,
607 -5, 0, 2, 9, 4, -9, -12, -17, -13, 1, 14, 25,
608 40, 0, 2, -1, 49, 9, -5, -19, -5, 97, -16, 0, 15,
609 97, 0, 17, 31, 54, 5, 5, -13, -34, -2, 8, -11, 7, 78,
610 15, 0, 0, -19, 0, 12, 2, 8, 17, 11, -21, 31, 13, 2, 31,
611 -2, 0, 15, 4, 2, 97, 13, 49, -5, -5, -19, -16, 1, 0, -1, 40,
612 0, 0, -21, 0, -4, -6, -5, -13, -12, -5, -23, -9, 9, 7, 0, 9, 26,
613 9, 0, 11, 2, 2, 2, 55, -11, -14, -28, 12, -21, -11, 1, 1, 7, 4, 21,
614 -11, 0, 2, -21, -12, -2, -12, -7, 13, 2, -1, -13, 2, -10, 6, 31, 2, -22, 23,
615 7, 0, 31, 8, 13, -7, -7, -15, -15, -3, 10, -31, 31, 6, -18, 9, 6, -17, -5, 133,
616 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
617 9, 0, 12, 17, 17, -12, -9, 28, -13, -3, 0, -12, 0, 8, 4, -11, 2, -5, -5, -5, 0, 47,
618 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 };
619 /*EXPERIMENTAL MATRICES: Blosum Series*/
620 /*Blosum Series rescaled on blosum62mt,
623 Lambda Blosum80mt=4.5
632 23, 18, 18, 9, 14, 80,
633 33, 33, 14, 28, 23, 18, 71,
634 23, 23, 9, 23, 33, 18, 18, 99,
635 33, 23, 23, 14, 18, 33, 28, 23, 61,
636 33, 33, 18, 33, 42, 28, 28, 23, 23, 52,
637 28, 28, 33, 28, 28, 42, 23, 28, 42, 23, 52,
638 37, 23, 23, 18, 28, 23, 23, 42, 37, 42, 42, 61,
639 33, 52, 28, 37, 28, 28, 33, 28, 33, 33, 23, 33, 71,
640 28, 23, 18, 28, 37, 14, 28, 37, 18, 37, 18, 14, 18, 85,
641 37, 28, 23, 28, 42, 18, 23, 33, 23, 33, 23, 28, 28, 33, 71,
642 28, 23, 23, 28, 28, 28, 23, 28, 18, 37, 23, 33, 23, 28, 47, 71,
643 37, 33, 23, 33, 33, 28, 33, 28, 28, 33, 23, 23, 33, 28, 28, 28, 52,
644 37, 33, 23, 28, 23, 23, 23, 23, 33, 28, 33, 33, 37, 33, 33, 18, 42, 56,
645 37, 23, 23, 23, 18, 37, 18, 18, 52, 23, 37, 33, 23, 14, 18, 28, 28, 37, 56,
646 9, 9, 23, 14, 28, 37, 37, 9, 18, 23, 23, 18, 0, 18, 28, 33, 18, 9, 18, 128,
647 0, -1, -2, -1, -1, -1, -1, -1, 0, 0, 0, 0, 0, -1, 0, -1, 0, 0, 0, -2, -1,
648 -4, -3, -6, -1, -2, 3, -3, 0, -1, -1, 3, -1, -4, -2, -1, 0, -2, -1, 1, 5, -1, 9,
649 0, 0, 0, 0, 5, -4, -2, 0, -3, 1, -1, -1, -1, 0, 4, 0, -1, -1, -3, -1, 0, -2, 4,
662 20, 10, 20, 10, 10, 100,
663 40, 30, 10, 30, 20, 10, 100,
664 20, 40, 10, 30, 40, 30, 20, 120,
665 30, 10, 30, 10, 10, 40, 0, 10, 80,
666 30, 40, 10, 30, 50, 10, 20, 30, 10, 90,
667 30, 0, 30, 0, 10, 40, 0, 10, 60, 20, 80,
668 30, 10, 30, 10, 20, 40, 10, 20, 50, 30, 60, 90,
669 20, 70, 10, 50, 40, 10, 40, 50, 10, 40, 10, 20, 100,
670 30, 20, 10, 30, 30, 0, 20, 20, 10, 30, 10, 20, 20, 110,
671 30, 40, 10, 40, 60, 10, 20, 40, 10, 50, 20, 40, 40, 30, 90,
672 30, 30, 10, 20, 40, 10, 20, 40, 10, 60, 20, 30, 40, 20, 50, 90,
673 50, 40, 30, 40, 40, 20, 40, 30, 20, 40, 20, 30, 50, 30, 40, 30, 80,
674 40, 30, 30, 30, 30, 20, 20, 20, 30, 30, 30, 30, 40, 30, 30, 30, 50, 90,
675 40, 10, 30, 10, 20, 30, 10, 10, 70, 20, 50, 50, 10, 20, 20, 10, 20, 40, 80,
676 10, 0, 20, 0, 10, 50, 20, 20, 10, 10, 20, 30, 0, 0, 20, 10, 10, 20, 10, 150,
677 0, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, -1, -1, 0, 0, -1, -2, -1,
678 -2, -3, -2, -3, -2, 3, -3, 2, -1, -2, -1, -1, -2, -3, -1, -2, -2, -2, -1, 2, -1, 7,
679 -1, 1, -3, 1, 4, -3, -2, 0, -3, 1, -3, -1, 0, -1, 3, 0, 0, -1, -2, -3, -1, -2, 4,
688 20, 10, 20, 10, 10, 93,
689 41, 31, 10, 25, 20, 10, 87,
690 25, 36, 5, 31, 41, 31, 20, 103,
691 25, 10, 31, 5, 10, 36, 5, 10, 77,
692 36, 36, 10, 31, 46, 15, 25, 36, 15, 82,
693 25, 5, 25, 5, 10, 41, 5, 15, 51, 20, 72,
694 31, 15, 25, 10, 20, 41, 15, 20, 51, 25, 56, 87,
695 25, 67, 15, 51, 36, 10, 36, 46, 10, 41, 10, 20, 87,
696 36, 20, 10, 25, 31, 10, 15, 20, 15, 31, 15, 20, 20, 103,
697 31, 36, 15, 36, 56, 15, 20, 46, 15, 51, 20, 36, 41, 25, 87,
698 25, 31, 10, 25, 36, 15, 20, 41, 15, 56, 20, 25, 36, 25, 46, 87,
699 51, 41, 31, 36, 36, 20, 36, 31, 20, 36, 20, 25, 46, 31, 36, 31, 77,
700 41, 36, 31, 31, 31, 20, 25, 25, 31, 36, 25, 36, 41, 25, 36, 31, 51, 82,
701 36, 10, 31, 10, 20, 31, 10, 15, 62, 20, 46, 46, 15, 20, 20, 20, 25, 41, 77,
702 15, 0, 15, 0, 10, 41, 10, 20, 15, 10, 20, 25, 5, 5, 20, 15, 10, 15, 15, 124,
703 -1, -3, -4, -3, -2, -3, -3, -2, -2, -2, -2, -2, -2, -3, -2, -2, -1, -1, -2, -5, -2,
704 -4, -5, -5, -6, -5, 4, -6, 3, -3, -4, -2, -3, -4, -6, -3, -4, -3, -3, -3, 3, -3, 11,
705 -2, 0, -7, 1, 6, -6, -4, 0, -6, 1, -5, -3, -1, -2, 5, 0, -1, -2, -4, -5, -1, -4, 6,
714 43, 38, 19, 38, 33, 14, 62,
715 24, 43, 19, 38, 33, 24, 19, 72,
716 33, 24, 24, 24, 24, 38, 19, 19, 67,
717 28, 38, 4, 33, 33, 4, 24, 28, 24, 62,
718 24, 19, 4, 14, 19, 38, 14, 24, 43, 19, 62,
719 28, 19, 9, 19, 24, 33, 19, 19, 43, 38, 52, 77,
720 33, 52, 14, 48, 43, 19, 38, 48, 28, 43, 19, 24, 57,
721 43, 28, 19, 24, 28, 14, 28, 33, 24, 28, 24, 24, 28, 67,
722 33, 38, 4, 43, 48, 9, 24, 52, 24, 38, 28, 33, 38, 38, 67,
723 24, 28, 19, 24, 24, 14, 19, 43, 28, 48, 19, 33, 33, 33, 43, 67,
724 43, 38, 38, 38, 33, 24, 43, 28, 28, 33, 19, 28, 43, 43, 28, 33, 52,
725 43, 38, 24, 33, 28, 19, 33, 24, 38, 33, 24, 33, 38, 33, 28, 28, 48, 57,
726 38, 24, 24, 24, 24, 24, 28, 24, 52, 19, 43, 43, 24, 28, 24, 24, 28, 38, 62,
727 4, 9, 0, 0, 0, 33, 0, 24, 9, 14, 24, 9, 19, 4, 9, 43, 28, 9, 0, 96,
728 -1, -1, -4, -2, -1, -3, -2, -2, -1, -2, -2, -2, -1, -2, -1, -2, -1, -1, -1, -5, -2,
729 -4, -3, -1, -5, -5, 4, -6, -1, -2, -5, -2, -4, -2, -6, -5, -5, -3, -3, -3, -2, -3, 8,
730 -1, 2, -7, 3, 4, -6, -2, 1, -3, -1, -3, -2, 0, -1, 4, -1, -1, -2, -3, -7, -1, -5, 4,
738 20, 15, 10, 5, 10, 73,
739 41, 36, 20, 36, 36, 15, 57,
740 26, 41, 20, 36, 36, 26, 20, 68,
741 31, 26, 26, 20, 26, 36, 20, 20, 62,
742 26, 36, 10, 36, 31, 10, 26, 31, 26, 57,
743 26, 15, 5, 15, 20, 41, 15, 26, 47, 20, 62,
744 31, 20, 10, 20, 26, 36, 20, 20, 47, 36, 52, 73,
745 36, 47, 15, 47, 41, 20, 36, 47, 26, 41, 20, 26, 52,
746 41, 31, 20, 26, 31, 15, 31, 31, 26, 26, 20, 26, 31, 62,
747 31, 41, 10, 41, 47, 10, 26, 47, 26, 36, 26, 31, 36, 36, 62,
748 26, 31, 20, 26, 26, 15, 20, 41, 26, 52, 20, 31, 31, 31, 41, 68,
749 41, 36, 36, 36, 36, 20, 41, 31, 26, 31, 20, 26, 41, 41, 31, 31, 47,
750 41, 36, 26, 31, 31, 20, 31, 26, 36, 36, 26, 31, 36, 36, 31, 31, 41, 52,
751 36, 26, 26, 20, 26, 26, 26, 26, 52, 20, 41, 41, 26, 26, 26, 20, 31, 36, 57,
752 10, 10, 0, 5, 0, 31, 0, 20, 10, 15, 26, 15, 15, 10, 10, 41, 26, 10, 5, 99,
753 0, -1, -3, -1, -1, -3, -1, -1, -1, -1, -2, -1, 0, -1, -1, -1, 0, 0, -1, -4, -1,
754 -3, -3, 0, -4, -4, 5, -5, 0, -2, -4, -2, -3, -2, -5, -4, -4, -3, -3, -3, -1, -3, 8,
755 0, 2, -5, 2, 3, -5, -1, 1, -2, 0, -3, -2, 1, -1, 3, 0, -1, -1, -2, -6, -1, -4, 3,
763 21, 17, 17, 8, 12, 72,
764 38, 34, 21, 38, 34, 12, 55,
765 30, 38, 21, 38, 38, 25, 25, 60,
766 30, 25, 25, 25, 25, 38, 21, 25, 55,
767 30, 38, 12, 34, 34, 12, 25, 34, 25, 55,
768 25, 21, 8, 17, 21, 42, 17, 25, 42, 21, 60,
769 30, 25, 12, 21, 25, 34, 21, 25, 42, 34, 51, 60,
770 34, 42, 17, 42, 38, 21, 34, 42, 25, 38, 21, 25, 42,
771 38, 30, 21, 30, 30, 12, 34, 34, 25, 30, 21, 25, 34, 60,
772 34, 38, 12, 42, 42, 12, 30, 47, 25, 38, 25, 30, 38, 34, 51,
773 25, 30, 17, 30, 30, 17, 21, 42, 25, 47, 21, 34, 34, 34, 38, 60,
774 38, 34, 34, 34, 34, 21, 38, 30, 30, 34, 21, 25, 38, 38, 30, 34, 42,
775 38, 34, 25, 34, 34, 21, 34, 30, 34, 34, 25, 30, 34, 34, 30, 30, 38, 47,
776 34, 25, 25, 25, 25, 30, 30, 25, 51, 25, 42, 42, 25, 30, 25, 25, 30, 34, 51,
777 8, 12, 0, 4, 4, 34, 4, 21, 12, 21, 25, 17, 17, 8, 12, 42, 25, 12, 8, 107,
778 0, -1, -3, -1, -1, -2, -1, -1, -1, -1, -1, -1, 0, -1, -1, -1, 0, 0, -1, -4, -1,
779 -3, -3, 0, -4, -4, 7, -5, 0, -1, -4, -1, -2, -2, -5, -4, -4, -3, -3, -2, 0, -2, 10,
780 0, 2, -5, 3, 3, -5, 0, 2, -2, 0, -3, -2, 1, 0, 3, 0, 0, -1, -2, -6, -1, -4, 3,
788 19, 16, 16, 13, 13, 76,
789 39, 36, 19, 36, 36, 13, 49,
790 29, 36, 19, 36, 36, 26, 26, 56,
791 33, 26, 23, 26, 26, 39, 26, 26, 49,
792 29, 36, 13, 36, 33, 13, 29, 36, 26, 49,
793 26, 19, 9, 19, 19, 43, 19, 26, 46, 23, 59,
794 29, 26, 13, 23, 26, 36, 23, 26, 43, 33, 49, 53,
795 33, 39, 19, 39, 39, 19, 36, 39, 26, 36, 23, 26, 39,
796 36, 33, 23, 33, 33, 16, 33, 33, 26, 29, 23, 26, 33, 53,
797 33, 39, 13, 39, 43, 16, 29, 43, 26, 36, 26, 29, 36, 36, 46,
798 29, 33, 19, 29, 33, 16, 26, 39, 26, 46, 23, 33, 36, 33, 39, 56,
799 36, 36, 33, 36, 33, 19, 36, 29, 29, 33, 23, 26, 36, 36, 33, 33, 36,
800 36, 33, 26, 33, 33, 23, 36, 29, 33, 33, 26, 29, 36, 36, 33, 29, 36, 39,
801 33, 26, 26, 26, 26, 29, 29, 26, 46, 26, 43, 39, 26, 29, 26, 23, 29, 33, 49,
802 9, 13, 0, 6, 6, 36, 6, 23, 13, 19, 26, 16, 16, 9, 16, 46, 23, 13, 9, 122,
803 0, 0, -3, -1, 0, -2, -1, 0, 0, -1, -1, 0, 0, 0, 0, -1, 0, 0, 0, -5, -1,
804 -4, -4, 1, -5, -5, 11, -6, 0, 0, -5, 0, -2, -3, -6, -5, -5, -3, -3, -2, 1, -2, 14,
805 0, 2, -6, 3, 3, -6, 0, 2, -2, 1, -3, -2, 2, 0, 3, 1, 0, 0, -2, -7, 0, -5, 3,
813 25, 27, 31, 28, 29, 84,
814 29, 27, 31, 25, 29, 30, 51,
815 32, 27, 31, 60, 29, 31, 23, 61,
816 46, 27, 28, 28, 31, 14, 29, 23, 52,
817 28, 27, 27, 31, 30, 26, 29, 23, 21, 49,
818 30, 27, 35, 31, 30, 29, 31, 23, 15, 23, 57,
819 28, 27, 30, 31, 29, 12, 24, 20, 18, 25, 33, 53,
820 40, 27, 29, 27, 46, 31, 30, 28, 28, 60, 25, 28, 36,
821 60, 27, 34, 35, 51, 28, 28, 23, 22, 24, 29, 13, 31, 66,
822 36, 27, 28, 28, 27, 29, 30, 31, 34, 32, 24, 42, 32, 29, 35,
823 27, 27, 36, 31, 29, 60, 32, 46, 30, 28, 28, 25, 28, 28, 27, 40,
824 28, 27, 24, 27, 23, 29, 27, 21, 18, 22, 23, 13, 31, 29, 31, 31, 38,
825 31, 27, 32, 30, 29, 29, 61, 22, 16, 29, 30, 12, 28, 30, 30, 31, 29, 36,
826 28, 27, 29, 24, 24, 31, 23, 15, 32, 23, 26, 9, 30, 32, 29, 35, 29, 3, 53,
827 31, 27, 42, 31, 31, 31, 23, 22, 15, 26, 29, 25, 35, 31, 30, 31, 29, 0, 22, 132,
828 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
829 6, 0, 2, 10, 3, -2, -6, 38, -14, -7, -1, -19, 0, 5, 3, 1, 4, -29, -6, -19, 0, 97,
830 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
839 14, 26, 32, 17, 31, 70,
840 28, 26, 31, 14, 35, 32, 68,
841 36, 26, 33, 102, 28, 3, 23, 69,
842 64, 26, 17, 26, 26, 9, 28, 21, 48,
843 11, 26, 26, 31, 12, 28, 39, 17, 18, 52,
844 22, 26, 50, 33, 27, 31, 36, 19, 21, 24, 52,
845 22, 26, 28, 33, 29, 19, 17, 13, 16, 27, 37, 45,
846 57, 26, 28, 25, 64, 33, 22, 11, 22, 102, 14, 26, 38,
847 102, 26, 39, 50, 68, 30, 30, 16, 0, 24, 32, 17, 31, 87,
848 38, 26, 26, 11, 26, 35, 28, 32, 39, 35, 10, 50, 36, 28, 50,
849 24, 26, 38, 29, 28, 102, 36, 64, 22, 22, 11, 14, 27, 26, 25, 57,
850 26, 26, 10, 26, 23, 21, 22, 16, 17, 22, 8, 19, 33, 31, 26, 33, 46,
851 33, 26, 35, 28, 28, 28, 69, 17, 15, 4, 35, 10, 17, 27, 27, 31, 29, 42,
852 17, 26, 28, 10, 17, 24, 17, 21, 36, 28, 25, 16, 28, 18, 31, 50, 28, 9, 44,
853 31, 26, 50, 32, 36, 21, 21, 14, 14, 24, 34, 2, 50, 31, 12, 33, 31, 13, 22, 130,
854 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
855 9, 0, 12, 17, 17, -12, -9, 28, -13, -3, 0, -12, 0, 8, 4, -11, 2, -5, -5, -5, 0, 47,
856 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
864 13, 27, 29, 17, 23, 101,
865 27, 27, 30, 13, 23, 28, 64,
866 31, 27, 30, 124, 21, 15, 24, 76,
867 51, 27, 17, 29, 25, 14, 27, 26, 71,
868 18, 27, 29, 30, 8, 25, 24, 23, 20, 61,
869 22, 27, 39, 33, 22, 28, 28, 21, 24, 27, 70,
870 18, 27, 29, 30, 21, 12, 6, 18, 20, 26, 33, 73,
871 52, 27, 27, 28, 51, 33, 22, 18, 18, 124, 13, 29, 36,
872 124, 27, 34, 39, 64, 27, 25, 23, 18, 24, 27, 13, 30, 79,
873 36, 27, 29, 18, 29, 23, 29, 29, 34, 32, 13, 40, 31, 21, 39,
874 27, 27, 36, 29, 27, 124, 31, 51, 22, 18, 18, 13, 28, 29, 28, 52,
875 29, 27, 13, 29, 24, 19, 16, 22, 21, 18, 9, 14, 30, 30, 25, 33, 44,
876 33, 27, 32, 29, 27, 20, 76, 10, 19, 20, 32, 9, 17, 28, 22, 30, 29, 55,
877 17, 27, 21, 13, 6, 21, 23, 24, 44, 13, 21, 7, 29, 17, 23, 39, 26, 20, 60,
878 30, 27, 40, 29, 28, 19, 26, 16, 7, 25, 31, 9, 39, 30, 8, 30, 27, 18, 26, 143,
879 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
880 4, 0, -4, 8, -3, -30, -6, 49, -10, -7, -12, -18, 3, 3, -6, -11, 3, 2, 2, -5, 0, 59,
881 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
890 1, 0, 3, -3, 1, 7, 6,
891 6, 0, 2, 6, 0, -1, -3, 11,
892 12, 0, -3, -2, -2, -5, 5, 0, 2,
893 -1, 0, 0, 3, -1, 0, 3, -3, -3, 12,
894 0, 0, 11, 6, 3, 5, 3, -3, -2, -2, 3,
895 -1, 0, 2, 2, -1, -2, -1, -3, -4, -1, 9, 3,
896 7, 0, 1, 0, 12, 6, 0, -1, -1, 6, -3, -2, 11,
897 6, 0, 8, 11, 6, 0, 2, -4, -1, -2, 3, -4, 3, 11,
898 11, 0, -2, -1, 0, 1, 2, 1, 8, 7, -3, 13, 6, 0, 11,
899 -1, 0, 11, 2, 1, 6, 6, 12, 0, -1, -1, -3, -1, -2, 0, 7,
900 -2, 0, -3, 0, -3, -3, -3, -4, -2, -3, -3, -4, 2, 2, -2, 6, 3,
901 6, 0, 7, 2, 5, -2, 11, -2, -5, -1, 6, -6, -3, -1, 3, 3, 1, 3,
902 -3, 0, 0, -3, -1, 0, -3, -2, 1, -3, 4, -6, 2, 1, 3, 11, 0, -3, 2,
903 3, 0, 13, 1, 3, -2, 0, -4, -4, -2, 1, 1, 11, 2, -1, 2, -1, -4, -1, 12,
904 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
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981 /******************************COPYRIGHT NOTICE*******************************/
982 /*© Centro de Regulacio Genomica */
984 /*Cedric Notredame */
985 /*Fri Feb 18 08:27:45 CET 2011 - Revision 596. */
986 /*All rights reserved.*/
987 /*This file is part of T-COFFEE.*/
989 /* T-COFFEE is free software; you can redistribute it and/or modify*/
990 /* it under the terms of the GNU General Public License as published by*/
991 /* the Free Software Foundation; either version 2 of the License, or*/
992 /* (at your option) any later version.*/
994 /* T-COFFEE is distributed in the hope that it will be useful,*/
995 /* but WITHOUT ANY WARRANTY; without even the implied warranty of*/
996 /* MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the*/
997 /* GNU General Public License for more details.*/
999 /* You should have received a copy of the GNU General Public License*/
1000 /* along with Foobar; if not, write to the Free Software*/
1001 /* Foundation, Inc., 59 Temple Place, Suite 330, Boston, MA 02111-1307 USA*/
1002 /*............................................... |*/
1003 /* If you need some more information*/
1004 /* cedric.notredame@europe.com*/
1005 /*............................................... |*/
1009 /******************************COPYRIGHT NOTICE*******************************/