2 * Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
3 * Copyright (C) $$Year-Rel$$ The Jalview Authors
5 * This file is part of Jalview.
7 * Jalview is free software: you can redistribute it and/or
8 * modify it under the terms of the GNU General Public License
9 * as published by the Free Software Foundation, either version 3
10 * of the License, or (at your option) any later version.
12 * Jalview is distributed in the hope that it will be useful, but
13 * WITHOUT ANY WARRANTY; without even the implied warranty
14 * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
15 * PURPOSE. See the GNU General Public License for more details.
17 * You should have received a copy of the GNU General Public License
18 * along with Jalview. If not, see <http://www.gnu.org/licenses/>.
19 * The Jalview Authors are detailed in the 'AUTHORS' file.
21 package jalview.ws.dbsources;
23 import static org.testng.Assert.assertFalse;
24 import static org.testng.AssertJUnit.assertEquals;
25 import static org.testng.AssertJUnit.assertNotNull;
26 import static org.testng.AssertJUnit.assertNull;
27 import static org.testng.AssertJUnit.assertTrue;
29 import jalview.datamodel.DBRefEntry;
30 import jalview.datamodel.SequenceI;
31 import jalview.gui.JvOptionPane;
32 import jalview.util.DBRefUtils;
33 import jalview.xml.binding.uniprot.DbReferenceType;
34 import jalview.xml.binding.uniprot.Entry;
35 import jalview.xml.binding.uniprot.FeatureType;
36 import jalview.xml.binding.uniprot.LocationType;
37 import jalview.xml.binding.uniprot.PositionType;
39 import java.io.ByteArrayInputStream;
40 import java.io.InputStream;
41 import java.io.UnsupportedEncodingException;
42 import java.math.BigInteger;
43 import java.util.List;
45 import org.testng.Assert;
46 import org.testng.annotations.BeforeClass;
47 import org.testng.annotations.Test;
49 public class UniprotTest
52 @BeforeClass(alwaysRun = true)
53 public void setUpJvOptionPane()
55 JvOptionPane.setInteractiveMode(false);
56 JvOptionPane.setMockResponse(JvOptionPane.CANCEL_OPTION);
59 // adapted from http://www.uniprot.org/uniprot/A9CKP4.xml
60 private static final String UNIPROT_XML = "<?xml version='1.0' encoding='UTF-8'?>"
61 + "<uniprot xmlns=\"http://uniprot.org/uniprot\">"
62 + "<entry dataset=\"TrEMBL\" created=\"2008-01-15\" modified=\"2015-03-04\" version=\"38\">"
63 + "<accession>A9CKP4</accession>"
64 + "<accession>A9CKP5</accession>"
65 + "<name>A9CKP4_AGRT5</name>"
66 + "<name>A9CKP4_AGRT6</name>"
67 + "<protein><recommendedName><fullName>Mitogen-activated protein kinase 13</fullName></recommendedName></protein>"
68 + "<dbReference type=\"PDB\" id=\"2FSQ\"><property type=\"method\" value=\"X-ray\"/><property type=\"resolution\" value=\"1.40\"/></dbReference>"
69 + "<dbReference type=\"PDBsum\" id=\"2FSR\"/>"
70 + "<dbReference type=\"EMBL\" id=\"AE007869\"><property type=\"protein sequence ID\" value=\"AAK85932.1\"/><property type=\"molecule type\" value=\"Genomic_DNA\"/></dbReference>"
71 + "<feature type=\"signal peptide\" evidence=\"7\"><location><begin position=\"1\"/><end position=\"18\"/></location></feature>"
72 + "<feature type=\"propeptide\" description=\"Activation peptide\" id=\"PRO_0000027399\" evidence=\"9 16 17 18\"><location><begin position=\"19\"/><end position=\"20\"/></location></feature>"
73 + "<feature type=\"chain\" description=\"Granzyme B\" id=\"PRO_0000027400\"><location><begin position=\"21\"/><end position=\"247\"/></location></feature>"
74 + "<feature type=\"sequence variant\"><original>M</original><variation>L</variation><location><position position=\"41\"/></location></feature>"
75 + "<feature type=\"sequence variant\" description=\"Pathogenic\"><original>M</original><variation>L</variation><location><position position=\"41\"/></location></feature>"
76 + "<feature type=\"sequence variant\" description=\"Pathogenic\"><original>M</original><location><position position=\"41\"/></location></feature>"
77 + "<feature type=\"sequence variant\" description=\"Foo\"><variation>L</variation><variation>LMV</variation><original>M</original><location><position position=\"42\"/></location></feature>"
78 + "<feature type=\"sequence variant\" description=\"Foo\"><variation>LL</variation><variation>LMV</variation><original>ML</original><location><begin position=\"42\"/><end position=\"43\"/></location></feature>"
79 + "<feature type=\"sequence variant\" description=\"Foo Too\"><variation>LL</variation><variation>LMVK</variation><original>MLML</original><location><begin position=\"42\"/><end position=\"45\"/></location></feature>"
80 + "<sequence length=\"10\" mass=\"27410\" checksum=\"8CB760AACF88FE6C\" modified=\"2008-01-15\" version=\"1\">MHAPL VSKDL</sequence></entry>"
84 * Test the method that unmarshals XML to a Uniprot model
86 * @throws UnsupportedEncodingException
88 @Test(groups = { "Functional" })
89 public void testGetUniprotEntries() throws UnsupportedEncodingException
91 Uniprot u = new Uniprot();
92 InputStream is = new ByteArrayInputStream(UNIPROT_XML.getBytes());
93 List<Entry> entries = u.getUniprotEntries(is);
94 assertEquals(1, entries.size());
95 Entry entry = entries.get(0);
96 assertEquals(2, entry.getName().size());
97 assertEquals("A9CKP4_AGRT5", entry.getName().get(0));
98 assertEquals("A9CKP4_AGRT6", entry.getName().get(1));
99 assertEquals(2, entry.getAccession().size());
100 assertEquals("A9CKP4", entry.getAccession().get(0));
101 assertEquals("A9CKP5", entry.getAccession().get(1));
103 assertEquals("MHAPL VSKDL", entry.getSequence().getValue());
105 assertEquals("Mitogen-activated protein kinase 13", entry.getProtein()
106 .getRecommendedName().getFullName().getValue());
109 * Check sequence features
111 List<FeatureType> features = entry.getFeature();
112 assertEquals(9, features.size());
113 FeatureType sf = features.get(0);
114 assertEquals("signal peptide", sf.getType());
115 assertNull(sf.getDescription());
116 assertNull(sf.getStatus());
117 assertNull(sf.getLocation().getPosition());
118 assertEquals(1, sf.getLocation().getBegin().getPosition().intValue());
119 assertEquals(18, sf.getLocation().getEnd().getPosition().intValue());
120 sf = features.get(1);
121 assertEquals("propeptide", sf.getType());
122 assertEquals("Activation peptide", sf.getDescription());
123 assertNull(sf.getLocation().getPosition());
124 assertEquals(19, sf.getLocation().getBegin().getPosition().intValue());
125 assertEquals(20, sf.getLocation().getEnd().getPosition().intValue());
126 sf = features.get(2);
127 assertEquals("chain", sf.getType());
128 assertEquals("Granzyme B", sf.getDescription());
129 assertNull(sf.getLocation().getPosition());
130 assertEquals(21, sf.getLocation().getBegin().getPosition().intValue());
131 assertEquals(247, sf.getLocation().getEnd().getPosition().intValue());
133 sf = features.get(3);
134 assertEquals("sequence variant", sf.getType());
135 assertNull(sf.getDescription());
137 sf.getLocation().getPosition().getPosition().intValue());
138 assertNull(sf.getLocation().getBegin());
139 assertNull(sf.getLocation().getEnd());
141 sf = features.get(4);
142 assertEquals("sequence variant", sf.getType());
143 assertEquals("Pathogenic", sf.getDescription());
145 sf.getLocation().getPosition().getPosition().intValue());
146 assertNull(sf.getLocation().getBegin());
147 assertNull(sf.getLocation().getEnd());
149 sf = features.get(5);
150 assertEquals("sequence variant", sf.getType());
151 assertEquals("Pathogenic", sf.getDescription());
153 sf.getLocation().getPosition().getPosition().intValue());
154 assertNull(sf.getLocation().getBegin());
155 assertNull(sf.getLocation().getEnd());
157 sf = features.get(6);
158 assertEquals("sequence variant", sf.getType());
160 sf.getDescription());
162 sf.getLocation().getPosition().getPosition().intValue());
163 assertNull(sf.getLocation().getBegin());
164 assertNull(sf.getLocation().getEnd());
165 Assert.assertEquals(Uniprot.getDescription(sf),
166 "<html>p.Met42Leu" + "<br/> "
167 + "p.Met42LeuMetVal Foo</html>");
169 sf = features.get(7);
170 assertNull(sf.getLocation().getPosition());
171 assertEquals(42, sf.getLocation().getBegin().getPosition().intValue());
172 assertEquals(43, sf.getLocation().getEnd().getPosition().intValue());
173 Assert.assertEquals(Uniprot.getDescription(sf),
174 "<html>p.MetLeu42LeuLeu" + "<br/> "
175 + "p.MetLeu42LeuMetVal Foo</html>");
177 sf = features.get(8);
178 assertNull(sf.getLocation().getPosition());
179 assertEquals(42, sf.getLocation().getBegin().getPosition().intValue());
180 assertEquals(45, sf.getLocation().getEnd().getPosition().intValue());
181 Assert.assertEquals(Uniprot.getDescription(sf),
182 "<html>p.MLML42LeuLeu" + "<br/> "
183 + "p.MLML42LMVK Foo Too</html>");
186 * Check cross-references
188 List<DbReferenceType> xrefs = entry.getDbReference();
189 assertEquals(3, xrefs.size());
191 DbReferenceType xref = xrefs.get(0);
192 assertEquals("2FSQ", xref.getId());
193 assertEquals("PDB", xref.getType());
194 assertEquals("X-ray",
195 Uniprot.getProperty(xref.getProperty(), "method"));
197 Uniprot.getProperty(xref.getProperty(), "resolution"));
200 assertEquals("2FSR", xref.getId());
201 assertEquals("PDBsum", xref.getType());
202 assertTrue(xref.getProperty().isEmpty());
205 assertEquals("AE007869", xref.getId());
206 assertEquals("EMBL", xref.getType());
207 assertEquals("AAK85932.1",
208 Uniprot.getProperty(xref.getProperty(), "protein sequence ID"));
209 assertEquals("Genomic_DNA",
210 Uniprot.getProperty(xref.getProperty(), "molecule type"));
213 @Test(groups = { "Functional" })
214 public void testGetUniprotSequence() throws UnsupportedEncodingException
216 InputStream is = new ByteArrayInputStream(UNIPROT_XML.getBytes());
217 Entry entry = new Uniprot().getUniprotEntries(
219 SequenceI seq = new Uniprot().uniprotEntryToSequence(entry);
221 assertEquals(6, seq.getDBRefs().size()); // 2*Uniprot, PDB, PDBsum, 2*EMBL
222 assertEquals(seq.getSequenceAsString(),
223 seq.createDatasetSequence().getSequenceAsString());
224 assertEquals(2,seq.getPrimaryDBRefs().size());
225 List<DBRefEntry> res = DBRefUtils.searchRefs(seq.getPrimaryDBRefs(), "A9CKP4");
226 assertEquals(1,res.size());
227 assertTrue(res.get(0).isCanonical());
228 assertFalse(res.get(1).isCanonical());
232 * Test the method that formats the sequence id
234 * @throws UnsupportedEncodingException
236 @Test(groups = { "Functional" })
237 public void testGetUniprotEntryId() throws UnsupportedEncodingException
239 InputStream is = new ByteArrayInputStream(UNIPROT_XML.getBytes());
240 Entry entry = new Uniprot().getUniprotEntries(is).get(0);
243 * name formatted with Uniprot Entry name
245 String expectedName = "A9CKP4_AGRT5|A9CKP4_AGRT6";
246 assertEquals(expectedName,
247 Uniprot.getUniprotEntryId(entry));
251 * Test the method that formats the sequence description
253 * @throws UnsupportedEncodingException
255 @Test(groups = { "Functional" })
256 public void testGetUniprotEntryDescription()
257 throws UnsupportedEncodingException
259 InputStream is = new ByteArrayInputStream(UNIPROT_XML.getBytes());
260 Entry entry = new Uniprot().getUniprotEntries(is).get(0);
262 assertEquals("Mitogen-activated protein kinase 13",
263 Uniprot.getUniprotEntryDescription(entry));
266 @Test(groups = { "Functional" })
267 public void testGetDescription()
269 FeatureType ft = new FeatureType();
270 assertEquals("", Uniprot.getDescription(ft));
272 ft.setDescription("Hello");
273 assertEquals("Hello", Uniprot.getDescription(ft));
275 ft.setLocation(new LocationType());
276 ft.getLocation().setPosition(new PositionType());
277 ft.getLocation().getPosition().setPosition(BigInteger.valueOf(23));
279 ft.getVariation().add("y");
280 assertEquals("p.Lys23Tyr Hello", Uniprot.getDescription(ft));
282 // multiple variants generate an html description over more than one line
283 ft.getVariation().add("W");
284 assertEquals("<html>p.Lys23Tyr<br/> p.Lys23Trp Hello</html>",
285 Uniprot.getDescription(ft));
289 * up to 3 bases (original or variant) are shown using 3 letter code
291 ft.getVariation().clear();
292 ft.getVariation().add("KWE");
293 ft.setOriginal("KLS");
294 assertEquals("p.LysLeuSer23LysTrpGlu Hello",
295 Uniprot.getDescription(ft));
297 // adding a fourth original base switches to single letter code
298 ft.setOriginal("KLST");
299 assertEquals("p.KLST23LysTrpGlu Hello", Uniprot.getDescription(ft));
301 // adding a fourth variant switches to single letter code
302 ft.getVariation().clear();
303 ft.getVariation().add("KWES");
304 assertEquals("p.KLST23KWES Hello", Uniprot.getDescription(ft));
306 ft.getVariation().clear();
307 ft.getVariation().add("z"); // unknown variant - fails gracefully
309 assertEquals("p.Lys23z Hello", Uniprot.getDescription(ft));
311 ft.getVariation().clear(); // variant missing - is ignored
312 assertEquals("Hello", Uniprot.getDescription(ft));