> 1== M63632 1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91] M----------------------------------------------------------- -----------------------------------NGTE--GDNFYVPF----------- ---------------------------------------------SNKTGLARSPYEYPQ Y-YLAEPW------------K--------------------------------YSALAAY MFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANLFMVLFG-FTVTMYTS-MN- GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVICKPMGN-FRFGNTHAIMGV AFTWIMALAC-AAPPLVG-WSRYIP-------EGM----QCSCGPDYYTLNPNFNNESYV VYMFVVHFLVPFVIIFFCYGRLLCTV----KE---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAAQQE------- ------------------------------SASTQKAEKEVTRMVVLMVIGFLVCWVPYA SVAFYIFT-HQG-S--DFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCMITTLC-C- --GKNP-------------------LGDDE--SGASTSKT-E--VSSVS-TSPV------ ------------------------------------------------------------ -------------------SP-A--- > 2== U22180 1 rat opsin [J.Mol.Neurosci.5(3),207-209'94] M----------------------------------------------------------- -----------------------------------NGTE--GPNFYVPF----------- ---------------------------------------------SNITGVVRSPFEQPQ Y-YLAEPW------------Q--------------------------------FSMLAAY MFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGG-FTTTLYTS-LH- GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSN-FRFGENHAIMGV AFTWVMALAC-AAPPLVG-WSRYIP-------EGM----QCSCGIDYYTLKPEVNNESFV IYMFVVHFTIPMIVIFFCYGQLVFTV----KE---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAQQQE------- ------------------------------SATTQKAEKEVTRMVIIMVIFFLICWLPYA SVAMYIFT-HQG-S--NFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLC-C- --GKNP-------------------LGDDE--ASATASKT-E--------TSQV------ ------------------------------------------------------------ -------------------AP-A--- > 3== M92038 1 chicken green sensitive cone opsin [PNAS89,5932-5936'9 M----------------------------------------------------------- -----------------------------------NGTE--GINFYVPM----------- ---------------------------------------------SNKTGVVRSPFEYPQ Y-YLAEPW------------K--------------------------------YRLVCCY IFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADLFMACFG-FTVTFYTA-WN- GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVVCKPMGN-FRFSATHAMMGI AFTWVMAFSC-AAPPLFG-WSRYMP-------EGM----QCSCGPDYYTHNPDYHNESYV LYMFVIHFIIPVVVIFFSYGRLICKV----RE---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAQQQE------- ------------------------------SATTQKAEKEVTRMVILMVLGFMLAWTPYA VVAFWIFT-NKG-A--DFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCMITTIC-C- --GKNP-------------------FGDEDVSSTVSQSKT-E--VSSVS-SSQV------ ------------------------------------------------------------ -------------------SP-A--- > 4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish M----------------------------------------------------------- -----------------------------------NGTE--GKNFYVPM----------- ---------------------------------------------SNRTGLVRSPFEYPQ Y-YLAEPW------------Q--------------------------------FKILALY LFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGTIMVCFG-FTVTFYTA-IN- GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS-FKFSSSHAFAGI AFTWVMALAC-AAPPLFG-WSRYIP-------EGM----QCSCGPDYYTLNPDYNNESYV IYMFVCHFILPVAVIFFTYGRLVCTV----KA---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAQQQD------- ------------------------------SASTQKAEREVTKMVILMVFGFLIAWTPYA TVAAWIFF-NKG-A--DFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCMLTTIF-C- --GKNP-------------------LGDDE-SSTVSTSKT-E--VSS------V------ ------------------------------------------------------------ -------------------SP-A--- > 5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish M----------------------------------------------------------- -----------------------------------NGTE--GNNFYVPL----------- ---------------------------------------------SNRTGLVRSPFEYPQ Y-YLAEPW------------Q--------------------------------FKLLAVY MFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGAIMVCFG-FTVTFYTA-IN- GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVVCKPMGS-FKFSSTHASAGI AFTWVMAMAC-AAPPLVG-WSRYIP-------EGI----QCSCGPDYYTLNPEYNNESYV LYMFICHFILPVTIIFFTYGRLVCTV----KA---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAQQQD------- ------------------------------SASTQKAEREVTKMVILMVLGFLVAWTPYA TVAAWIFF-NKG-A--AFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCMLTTLF-C- --GKNP-------------------LGDEE-SSTVSTSKT-E--VSS------V------ ------------------------------------------------------------ -------------------SP-A--- > 6== L11864 1 Carassius auratus blue cone opsin [Biochemistry32,208- M----------------------------------------------------------- -----------------------------------KQVPEFHEDFYIPIPL--------- -------------------------------------------DINNLS--AYSPFLVPQ D-HLGNQG------------I--------------------------------FMAMSVF MFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANLFVAIFG-SPLSFYSF-FN- RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFERWLVICKPLGN-FTFKTPHAIAGC ILPWISALAA-SLPPLFG-WSRYIP-------EGL----QCSCGPDWYTTNNKYNNESYV MFLFCFCFAVPFGTIVFCYGQLLITL----KL---------------------------- ------------------------------------------------------------ ----------------------------------------------AAKAQAD------- ------------------------------SASTQKAEREVTKMVVVMVLGFLVCWAPYA SFSLWIVS-HRG-E--EFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCMM-KMV-C- --GKN--------------------IEEDE--ASTSSQVT-Q--VSS------V------ ------------------------------------------------------------ -------------------APEK--- > 7== M13299 1 human BCP <>[Science232(4747),193-202'86] M----------------------------------------------------------- -----------------------------------RKMS--EEEFYL---F--------- ---------------------------------------------KNISSV--GPWDGPQ Y-HIAPVW------------A--------------------------------FYLQAAF MGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFS-VFPVFVAS-CN- GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGN-FRFSSKHALTVV LATWTIGIGV-SIPPFFG-WSRFIP-------EGL----QCSCGPDWYTVGTKYRSESYT WFLFIFCFIVPLSLICFSYTQLLRAL----KA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAAQQQE------- ------------------------------SATTQKAEREVSRMVVVMVGSFCVCYVPYA AFAMYMVN-NRN-H--GLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIM-KMV-C- --GKA--------------------MTDES--DTCSSQKT-E--VSTVS-STQV------ ------------------------------------------------------------ -------------------GP-N--- > 8=opsin, greensensitive human (fragment) S07060 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DLAETVIA-STISIVNQ-VS- GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN-VRFDAKLAIVGI AFSWIWAAVW-TAPPIFG-WSRYWP-------HGL----KTSCGPDVFSGSSYPGVQSYM IVLMVTCCITPLSIIVLCYLQVWLAI----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAKQQKE------- ------------------------------SESTQKAEKEVTRMVVVMVLAFC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------- > 9== K03494 1 human GCP <>[Science232(4747),193-202'86] M--------------AQQWSLQRLAGRHPQDSYE-------------------------- -----------------------------------DSTQ--SSIFTYTN----------- ---------------------------------------------SNST---RGPFEGPN Y-HIAPRW------------V--------------------------------YHLTSVW MIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIA-STISVVNQ-VY- GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGN-VRFDAKLAIVGI AFSWIWAAVW-TAPPIFG-WSRYWP-------HGL----KTSCGPDVFSGSSYPGVQSYM IVLMVTCCITPLSIIVLCYLQVWLAI----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAKQQKE------- ------------------------------SESTQKAEKEVTRMVVVMVLAFCFCWGPYA FFACFAAA-NPG-Y--PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCIL-QLF--- --GKK--------------------VDDGS--ELSSASKT-E--VSSV---SSV------ ------------------------------------------------------------ -------------------SP-A--- > 10== Z68193 1 human Red Opsin <>[] M--------------AQQWSLQRLAGRHPQDSYE-------------------------- -----------------------------------DSTQ--SSIFTYTN----------- ---------------------------------------------SNST---RGPFEGPN Y-HIAPRW------------V--------------------------------YHLTSVW MIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIA-STISIVNQ-VS- GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVVCKPFGN-VRFDAKLAIVGI AFSWIWSAVW-TAPPIFG-WSRYWP-------HGL----KTSCGPDVFSGSSYPGVQSYM IVLMVTCCIIPLAIIMLCYLQVWLAI----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAKQQKE------- ------------------------------SESTQKAEKEVTRMVVVMIFAYCVCWGPYT FFACFAAA-NPG-Y--AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCIL-QLF--- --GKK--------------------VDDGS--ELSSASKT-E--VSSV---SSV------ ------------------------------------------------------------ -------------------SP-A--- > 11== M92036 1 Gecko gecko P521 [PNAS89,6841-6845'92] M--------------TEAWNVAVFAARRSRDD-D-------------------------- -----------------------------------DTTR--GSVFTYTN----------- ---------------------------------------------TNNT---RGPFEGPN Y-HIAPRW------------V--------------------------------YNLVSFF MIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDLVETLVA-STISVFNQ-IF- GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVVCKPFGN-IKFDSKLAIIGI VFSWVWAWGW-SAPPIFG-WSRYWP-------HGL----KTSCGPDVFSGSVELGCQSFM LTLMITCCFLPLFIIIVCYLQVWMAI----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAAQQKE------- ------------------------------SESTQKAEREVSRMVVVMIVAFCICWGPYA SFVSFAAA-NPG-Y--AFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCIM-QLF--- --GKK--------------------VDDGS--EASTTSRT-E--VSSVS-NSSV------ ------------------------------------------------------------ -------------------AP-A--- > 12== M62903 1 chicken visual pigment <>[BBRC173,1212-1217'90] M--------------AA-WEAAFAARRRHEE--E-------------------------- -----------------------------------DTTR--DSVFTYTN----------- ---------------------------------------------SNNT---RGPFEGPN Y-HIAPRW------------V--------------------------------YNLTSVW MIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADLGETVIA-STISVINQ-IS- GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWERWFVVCKPFGN-IKFDGKLAVAGI LFSWLWSCAW-TAPPIFG-WSRYWP-------HGL----KTSCGPDVFSGSSDPGVQSYM VVLMVTCCFFPLAIIILCYLQVWLAI----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------VAAQQKE------- ------------------------------SESTQKAEKEVSRMVVVMIVAYCFCWGPYT FFACFAAA-NPG-Y--AFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCIL-QLF--- --GKK--------------------VDDGS--EVST-SRT-E--VSSVS-NSSV------ ------------------------------------------------------------ -------------------SP-A--- > 13== S75720 1 chicken P-opsin <>[Science267(5203),1502-1506'95] M--------------S-----------------S-------------------------- -----------------------------------NSSQ--AP----------------- ---------------------------------------------PNGT---PGPFDGPQ WPYQAPQS------------T--------------------------------YVGVAVL MGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADLLVTLCG-SSVSLSNN-IN- GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALERYVVVCKPLGD-FQFQRRHAVSGC AFTWGWALLW-SAPPLLG-WSSYVP-------EGL----RTSCGPNWYTGGSNN--NSYI LSLFVTCFVLPLSLILFSYTNLLLTL----RA---------------------------- ------------------------------------------------------------ ----------------------------------------------AAAQQKE------- ------------------------------ADTTQRAEREVTRMVIVMVMAFLLCWLPYS TFALVVAT-HKG-I--IIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCLL-EMLCCG YQPQR--------------------TGKAS--PGTPGPHA-D--VTAAGLRNKV------ ------------------------------------------------------------ -------------------MP-AHPV > 14== M17718 1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87] M--------------------------------ES-G----------------------- -----------------------------------NVSS-----------SLFGNVSTAL RPEA------------------RLSA---ETRLLGWNVPPEELR---------------- --HIPEHW------------LT---------YPEPPESM--------------NYLLGTL YIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDFMMMVK--TPIFIYNS-FH- QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITRPMEG--KMTHGKAIAMI IFIYMYATPW-VVACYTETWGRFVP-------EGY----LTSCTFDYLT--DNFDTRLFV ACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------LRDQAKK--MNVES L------------------------RS-NVDKNKETAEIRIAKAAITICFLFFCSWTPYG VMSLIGAF-GDK-T--LLTPGATMIPACACKMVACIDPFVYAISHPRYRMELQ------- --KRCP----WLALNE---KAPE--SSAVA--STSTTQEP-Q------------------ -------QT--------------------------------------------------- -------------------TA-A--- > 15== X65879 1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92 M--------------------------------EY-H----------------------- -----------------------------------NVSS-----------VL-GNVSSVL RPDA------------------RLSA---ESRLLGWNVPPDELR---------------- --HIPEHW------------LI---------YPEPPESM--------------NYLLGTL YIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDFMMMIK--TPIFIYNS-FH- QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVITRPMEG--KMTHGKAIAMI IFIYLYATPW-VVACYTESWGRFVP-------EGY----LTSCTFDYLT--DNFDTRLFV ACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------LRDQAKK--MNVDS L------------------------RS-NVDKSKEAAEIRIAKAAITICFLFFASWTPYG VMSLIGAF-GDK-T--LLTPGATMIPACTCKMVACIDPFVYAISHPRYRMELQ------- --KRCP----WLAISE---KAPE--SRAAI--STSTTQEQ-Q------------------ -------QT--------------------------------------------------- -------------------TA-A--- > 16== M17730 1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87] M--------------------------------EPLC----------------------- -----------------------------------NASE-----------PP-------L RPEA------------------R-SSGNGDLQFLGWNVPPDQIQ---------------- --YIPEHW------------LT---------QLEPPASM--------------HYMLGVF YIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK--APIF--NS-FH- RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTFTKAVIMN IIIWLYCTPW-VVLPLTQFWDRFVP-------EGY----LTSCSFDYLS--DNFDTRLFV GTIFFFSFVCPTLMILYYYSQIVGHVFSHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------LREQAKK--MNVES L------------------------RS-NVDKSKETAEIRIAKAAITICFLFFVSWTPYG VMSLIGAF-GDK-S--LLTQGATMIPACTCKLVACIDPFVYAISHPRYRLELQ------- --KRCP----WLGVNE---KSGE--ISSAQ--ST-TTQEQ-Q------------------ -------QT--------------------------------------------------- -------------------TA-A--- > 17== X65880 1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92 M--------------------------------DALC----------------------- -----------------------------------NASE-----------PP-------L RPEA------------------RMSSGSDELQFLGWNVPPDQIQ---------------- --YIPEHW------------LT---------QLEPPASM--------------HYMLGVF YIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDLIMCLK--APIFIYNS-FH- RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVITKPMNR--NMTFTKAVIMN IIIWLYCTPW-VVLPLTQFWDRFVP-------EGY----LTSCSFDYLS--DNFDTRLFV GTIFLFSFVVPTLMILYYYSQIVGHVFNHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------LREQAKK--MNVES L------------------------RS-NVDKSKETAEIRIAKAAITICFLFFVSWTPYG VMSLIGAF-GDK-S--LLTPGATMIPACTCKLVACIEPFVYAISHPRYRMELQ------- --KRCP----WLGVNE---KSGE--ASSAQ--ST-TTQEQTQ------------------ -------QT--------------------------------------------------- -------------------SA-A--- > 18== D50584 1 Hemigrapsus sanguineus opsin BcRh2 [J.Exp.Biol.1 M--------------------------------------------TNATGPQMAYYGAAS MDFGYPE----------------------------GVSI-----------VD-------- ------------------------------------FVRPEIKP---------------- --YVHQHW------------YN---------YPPVNPMW--------------HYLLGVI YLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDLIMLTTN-VPFFTYNC-FSG GVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDRYNIICNGFNG-PKLTTGKAVVFA LISWVIAIGC-ALPPFFG-WGNYIL-------EGI----LDSCSYDYLT--QDFNTFSYN IFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAA---------------------------- ------------------------------------------------------------ ----------------------------------------------MRAQAKK--MNVST L------------------------RS-N-EADAQRAEIRIAKTALVNVSLWFICWTPYA LISLKGVM-GDT-S--GITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAIT------- --QHLP----WFCVHE---TETKS-NDDSQ--SNSTVAQ--------------------- ------------------------------------------------------------ -------------------DK-A--- > 19== D50583 1 Hemigrapsus sanguineus opsin BcRh1 [J.Exp.Biol.1 M--------------------------------------------ANVTGPQMAFYGSGA ATFGYPE----------------------------GMTV-----------AD-------- ------------------------------------FVPDRVKH---------------- --MVLDHW------------YN---------YPPVNPMW--------------HYLLGVV YLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDLIMLTTN-FPPFCYNC-FSG GRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDRYNIICNGFNG-PKLTQGKATFMC GLAWVISVGW-SLPPFFG-WGSYTL-------EGI----LDSCSYDYFT--RDMNTITYN ICIFIFDFFLPASVIVFSYVFIVKAIFAHEAA---------------------------- ------------------------------------------------------------ ----------------------------------------------MRAQAKK--MNVTN L------------------------RS-N-EAETQRAEIRIAKTALVNVSLWFICWTPYA AITIQGLL-GNA-E--GITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAIT------- --QHLP----WFCVHE---KDPND-VEENQ--SSNTQTQ--------------------- ------------------------------------------------------------ -------------------EK-S--- > 20== K02320 1 D.melanogaster opsin <>[Cell40,851-858'85] M--------------------------------E------SFAVAAAQLGPHFAPLS--- -----------------------------------NGSV-----------VD-------- ------------------------------------KVTPDMAH---------------- --LISPYW------------NQ---------FPAMDPIW--------------AKILTAY MIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINL-YF- ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKM ----------------------YVP-------EGN----LTSCGIDYLE--RDWNPRSYL IFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------MREQAKK--MNVKS L------------------------RS-S-EDAEKSAEGKLAKVALVTITLWFMAWTPYL VINCMGLF--KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK------- --EKCP----CCVFGK---VDDGK-SSDAQ--SQATASEA-E------------------ ------------------------------------------------------------ -------------------SK-A--- > 21== K02315 1 D.melanogaster ninaE <>[Cell40,839-850'85] M--------------------------------E------SFAVAAAQLGPHFAPLS--- -----------------------------------NGSV-----------VD-------- ------------------------------------KVTPDMAH---------------- --LISPYW------------NQ---------FPAMDPIW--------------AKILTAY MIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINL-YF- ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKI AYIWFMSSIW-CLAPAFG-WSRYVP-------EGN----LTSCGIDYLE--RDWNPRSYL IFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------MREQAKK--MNVKS L------------------------RS-S-EDAEKSAEGKLAKVALVTITLWFMAWTPYL VINCMGLF--KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK------- --EKCP----CCVFGK---VDDGK-SSDAQ--SQATASEA-E------------------ ------------------------------------------------------------ -------------------SK-A--- > 22== X65877 1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204' M--------------------------------D------SFAAVATQLGPQFAAPS--- -----------------------------------NGSV-----------VD-------- ------------------------------------KVTPDMAH---------------- --LISPYW------------DQ---------FPAMDPIW--------------AKILTAY MIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDFGIMITN-TPMMGINL-YF- ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVIVKGMAG-RPMTIPLALGKI AYIWFMSTIWCCLAPVFG-WSRYVP-------EGN----LTSCGIDYLE--RDWNPRSYL IFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------MREQAKK--MNVKS L------------------------RS-S-EDADKSAEGKLAKVALVTISLWFMAWTPYL VINCMGLF--KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLALK------- --EKCP----CCVFGK---VDDGK-SSEAQ--SQATTSEA-E------------------ ------------------------------------------------------------ -------------------SK-A--- > 23== M12896 1 D.melanogaster Rh2 <>[Cell44,705-710'86] M--------------------------------ER-SHLPETPFDLAHSGPRFQAQSSG- -----------------------------------NGSV-----------LD-------- ------------------------------------NVLPDMAH---------------- --LVNPYW------------SR---------FAPMDPMM--------------SKILGLF TLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQ-SPVMIINF-YY- ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVIVKGING-TPMTIKTSIMKI LFIWMMAVFW-TVMPLIG-WSAYVP-------EGN----LTACSIDYMT--RMWNPRSYL ITYSLFVYYTPLFLICYSYWFIIAAVAAHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------MREQAKK--MNVKS L------------------------RS-S-EDCDKSAEGKLAKVALTTISLWFMAWTPYL VICYFGLF--KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVLK------- --EKCP----MCVFGN---TDEPKPDAPAS--DTETTSEA-D------------------ ------------------------------------------------------------ -------------------SK-A--- > 24== X65878 1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92 M--------------------------------ER-SLLPEPPLAMALLGPRFEAQTGG- -----------------------------------NRSV-----------LD-------- ------------------------------------NVLPDMAP---------------- --LVNPHW------------SR---------FAPMDPTM--------------SKILGLF TLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQ-SPVMIINF-YY- ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVIVKGING-TPMTIKTSIMKI AFIWMMAVFW-TIMPLIG-WSSYVP-------EGN----LTACSIDYMT--RQWNPRSYL ITYSLFVYYTPLFMICYSYWFIIATVAAHEKA---------------------------- ------------------------------------------------------------ ----------------------------------------------MRDQAKK--MNVKS L------------------------RS-S-EDCDKSAENKLAKVALTTISLWFMAWTPYL IICYFGLF--KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVLK------- --EKCP----MCVCGT---TDEPKPDAPPS--DTETTSEA-E------------------ ------------------------------------------------------------ -------------------SK-D--- > 25== U26026 1 Apis mellifera long-wavelength rhodopsin <>[] M--------------------------------------------IAVSGPSYEAFSYG- ---GQAR--------------------------FNNQTV-----------VD-------- ------------------------------------KVPPDMLH---------------- --LIDANW------------YQ---------YPPLNPMW--------------HGILGFV IGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNFLMMFCM-SPPMVINC-YY- ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVIVKGLSG-KPLSINGALIRI IAIWLFSLGW-TIAPMFG-WNRYVP-------EGN----MTACGTDYFN--RGLLSASYL VCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKN---------------------------- ------------------------------------------------------------ ----------------------------------------------MREQAKK--MNVAS L------------------------RS-S-ENQNTSAECKLAKVALMTISLWFMAWTPYL VINFSGIF--NL-V--KISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAALF------- --AKFP----SLAC-A---AEPSS-DAVST--TSGTTTVT-D------------------ ------------------------------------------------------------ ---------------NEK-SN-A--- > 26== L03781 1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93] M----------------------------------------------ANQLSYSSLGWP- ---YQP-----------------------------NASV-----------VD-------- ------------------------------------TMPKEMLY---------------- --MIHEHW------------YA---------FPPMNPLW--------------YSILGVA MIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDFCMMAFM-MPTMTSNC-FA- ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVIVRGMAA-APLTHKKATLLL LFVWIWSGGW-TILPFFG-WSRYVP-------EGN----LTSCTVDYLT--KDWSSASYV VIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQ---------------------------- ------------------------------------------------------------ ----------------------------------------------LREQAKK--MNVAS L------------------------RANA-DQQKQSAECRLAKVAMMTVGLWFMAWTPYL IISWAGVF--SSGT--RLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAALY------- --QRFP----SLACGS---GESGS-DVKSE--ASATTTME-E------------------ ------------------------------------------------------------ ---------------KPKIPE-A--- > 27== X07797 1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88] M----------------------------------------------------------- ---VESTTLV------------------NQTWWY-NPTV-----------D--------- ------------------------------------------------------------ ---IHPHW------------AK---------FDPIPDAV--------------YYSVGIF IGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDLSFSAINGFPLKTISA-FM- KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVIGRPMAASKKMSHRRAFLMI IFVWMWSIVW-SVGPVFN-WGAYVP-------EGI----LTSCSFDYLS--TDPSTRSFI LCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKE---------------------------- ------------------------------------------------------------ ----------------------------------------------MAAMAKR--LNAKE L------------------------RK---AQAGASAEMKLAKISMVIITQFMLSWSPYA IIALLAQF-GPA-E--WVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAIQ------- --TTFPWLLTCCQFDE---KECED-ANDAE--EEVVASER---GGESRD-AAQMKEMMAM MQKMQAQQAAYQPPPPPQGY--PPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAP PQVEAPQGAPPQGVDNQA-YQ-A--- > 28== X70498 1 Todarodes pacificus rhodopsin [FEBS317(1-2),5-11'93] M----------------------------------------------------------- ---GRDLR-D------------------NETWWY-NPSI-----------V--------- ------------------------------------------------------------ ---VHPHW------------RE---------FDQVPDAV--------------YYSLGIF IGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDFTFSLVNGFPLMTISC-FL- KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVIGRPMAASKKMSHRRAFIMI IFVWLWSVLW-AIGPIFG-WGAYTL-------EGV----LCNCSFDYIS--RDSTTRSNI LCMFILGFFGPILIIFFCYFNIVMSVSNHEKE---------------------------- ------------------------------------------------------------ ----------------------------------------------MAAMAKR--LNAKE L------------------------RK---AQAGANAEMRLAKISIVIVSQFLLSWSPYA VVALLAQF-GPL-E--WVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAIS------- --QTFPWVLTCCQFDD---KETED-DKDAE--TEIPAGES-SDAAPSAD-AAQMKEMMAM MQKMQQQQAAY----PPQGYAPPPQGYPPQGY--PPQGYPPQGYPPQGYPP---PPQGAP PQ-GAPPAAPPQGVDNQA-YQ-A--- > 29== L21195 1 human serotonin 5-HT7 receptor protein 30== L15228 1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93] M----------------------------------------------------------- ------------------------------------------------------------ --------------PHLLSGFLEVTA---------------------------------- --SPAPTW-----------------------DAPPDNVS--GCGEQINYGRVEKVVIGSI LTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVAV-MPFVSVTDLIG- GKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI LSVWLLSASI-TLPPLFG-WAQNVN--DDK---------VCLISQDF----------GYT IYSTAVAFYIPMSVMLFMYYQIYKAAR--------------------------------- -----------------KSAAKHKFPGFPRVQPESVI----------------------S LNGVVK----------------------LQKEVEECAN--------LSRLLKH------- -------------------------ER-K-NISIFKREQKAATTLGIIVGAFTVCWLPFF LLSTARPFICGT-SCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTSR-SLL--- ----------QCQYRN-INRKLSA-AGMHE--ALKLAERP-E--------RSEF-----V LQNSDH--------CGKKGHD--------------------------------------- ----------------------T--- > 31=p A47425 serotonin receptor 5HT-7 - rat M----------------------------------------------------------- ------------------------------------------------------------ --------------PHLLSGFLEVTA---------------------------------- --SPAPTW-----------------------DAPPDNVS--GCGEQINYGRVEKVVIGSI LTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADLSVAVAV-MPFVSVTDLIG- GKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMI LSVWLLSASI-TLPPLFG-WAQNVN--DDK---------VCLISQDF----------GYT IYSTAVAFYIPMSVMLFMYYQIYKAAR--------------------------------- -----------------KSAAKHKFPGFPRVQPESVI----------------------S LNGVVK----------------------LQKEVEECAN--------LSRLLKH------- -------------------------ER-K-NISIFKREQKAATTLGIIVGAFTVCWLPFF LLSTARPFICGT-SCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYR-SLL--- ----------QCQYRN-INRKLSA-AGMHE--ALKLAERP-E--------RSEF-----V LQNSDH--------CGKKGHD--------------------------------------- ----------------------T--- > 32== M83181 1 human serotonin receptor <>[JBC267(11),7553-7562'92] M-DVLSPGQ--------------------------------------------------- -----------------GNNTTSPPAPFETGG---NTTG--------------------I -------------------------S---------------------------------- --DVTVSY---------------------------------------------QVITSLL LGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLV-LPMAALYQ-VL- NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALI SLTWLIGFLI-SIPPMLG-WRTPEDRSDPD---------ACTISKDH----------GYT IYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK---------------------------- -----------TVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGAL-C ANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAP-----ASFERK------- ----NERNA----------------EA-K-RKMALARERKTVKTLGIIMGTFILCWLPFF IVALVLPF-CES-SC-HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK-KII--- ----------KCKFCR-------------------------------------------- ------------------------------------------------------------ ----------------------Q--- > 33=p A35181 serotonin receptor class 1A - rat M-DVFSFGQ--------------------------------------------------- -----------------GNNTTASQEPFGTGG---NVTS--------------------I -------------------------S---------------------------------- --DVTFSY---------------------------------------------QVITSLL LGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLV-LPMAALYQ-VL- NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALI SLTWLIGFLI-SIPPMLG-WRTPEDRSDPD---------ACTISKDH----------GYT IYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK---------------------------- -----------TVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTP-C TNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAP-----ACLERK------- ----NERNA----------------EA-K-RKMALARERKTVKTLGIIMGTFILCWLPFF IVALVLPF-CES-SC-HMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK-KII--- ----------KCKFCR-------------------------------------------- ------------------------------------------------------------ ----------------------R--- > 34== L06803 1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93] M-ANFTFGDLALD----------------------------------------------- -------------VARMGGLASTPSGLRSTGL---TTPG--------------------L SPTG------------------LVTS---------------------------------- --DFNDSYGLTGQFINGSHSSRSRDNASAN-DTSATNMTDDRYWSLTVYSHEHLVLTSVI LGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVLV-MPLSVVSE-IS- KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSARRILLMI MVVWIVALFI-SIPPLFG-WRDPNN--DPD------KTGTCIISQDK----------GYT IFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEETTLVASPKTEYSVV SDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK----------------NRAKKLPEN ANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEEAS-IAMLERQ-CNNGKK ISSNDTPYS----------------RT-R-EKLELKRERKAARTLAIITGAFLICWLPFF IIALIGPF-VDP-E--GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQ-KIL--- ----------FGKYRR-------------------------------------------- ------------------GH---------------------------------------- ----------------------R--- > 35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail M-ANFTFGDLALD----------------------------------------------- -------------VARMGGLASTPSGLRSTGL---TTPG--------------------L SPTG------------------LVTS---------------------------------- --DFNDSYGLTGQFINGSHSSRSRDNASAN-DTSATNMTDDRYWSLTVYSHEHLVLTSVI LGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADLMVAVLV-MPLSVVSE-IS- KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAVTS-IDYIRRRSARRILLMI MVVWIVALFI-SIPPLFG-WRDPNN--DPD------KTGTCIISQDK----------GYT IFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEETTLVASPKTEYSVV SDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK----------------NRAKKLPEN ANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEEAS-IAMLERQ-CNNGKK ISSNDTPYS----------------RT-R-EKLELKRERKAARTLAIITGAFLICWLPFF IIALIGPF-VDP-E--GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAFQ-KIL--- ----------FGKYRR-------------------------------------------- ------------------GH---------------------------------------- ----------------------R--- > 36== X95604 1 Bombyx mori serotonin receptor [InsectBiochem.Mol.Bi M-EGAE-GQEELDWEA-------------------------------------------- ---------LYLRLP-----------LQNCSW---NSTG--------------------W EPNW------------------NVTV---------------------------------- --VPNTTW----------------WQASAPFDTPAALVR--------------AAAKAVV LGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADLLVACLV-MPLGAVYE-VV- QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDRYWAVTN-IDYIHASTAKRVGMMI ACVWTVSFFV-CIAQLLG-WK------DPDWNQRVSEDLRCVVSQDV----------GYQ IFATASSFYVPVLIILILYWRIYQTARKRIRR---------------------------- -----------------RRGATARGGVGPPPVP--------------------------- AGGALVAGGGSGGIAAAVVAVIGRP---LPTISETTTTGFTNVSSNNTSPEKQSCANGLE A---DPPTTGYGAVAAAYYPSLVRRKP-K-EAADSKRERKAAKTLAIITGAFVACWLPFF VLAILVPT-CDC-E---VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAFQ-RLL--- ----------CGRRVRRR------------------------------------------ -----------------RAP---------------------------------------- ----------------------Q---