#include "muscle.h" #include "profile.h" #include "pwpath.h" #include #define TRACE 0 #define EQ(a, b) (fabs(a-b) < 0.1) SCORE TraceBack(const ProfPos *PA, unsigned uLengthA, const ProfPos *PB, unsigned uLengthB, const SCORE *DPM_, const SCORE *DPD_, const SCORE *DPI_, PWPath &Path) { #if TRACE Log("\n"); Log("TraceBack LengthA=%u LengthB=%u\n", uLengthA, uLengthB); #endif assert(uLengthB > 0 && uLengthA > 0); const unsigned uPrefixCountA = uLengthA + 1; const unsigned uPrefixCountB = uLengthB + 1; Path.Clear(); unsigned uPrefixLengthA = uLengthA; unsigned uPrefixLengthB = uLengthB; const SCORE scoreM = DPM(uPrefixLengthA, uPrefixLengthB); SCORE scoreD = DPD(uPrefixLengthA, uPrefixLengthB); SCORE scoreI = DPI(uPrefixLengthA, uPrefixLengthB); const ProfPos &LastPPA = PA[uLengthA - 1]; const ProfPos &LastPPB = PB[uLengthB - 1]; scoreD += LastPPA.m_scoreGapClose; scoreI += LastPPB.m_scoreGapClose; char cEdgeType = cInsane; SCORE scoreMax; if (scoreM >= scoreD && scoreM >= scoreI) { scoreMax = scoreM; cEdgeType = 'M'; } else if (scoreD >= scoreM && scoreD >= scoreI) { scoreMax = scoreD; cEdgeType = 'D'; } else { assert(scoreI >= scoreM && scoreI >= scoreD); scoreMax = scoreI; cEdgeType = 'I'; } for (;;) { if ('S' == cEdgeType) break; PWEdge Edge; Edge.cType = cEdgeType; Edge.uPrefixLengthA = uPrefixLengthA; Edge.uPrefixLengthB = uPrefixLengthB; Path.PrependEdge(Edge); char cPrevEdgeType; unsigned uPrevPrefixLengthA = uPrefixLengthA; unsigned uPrevPrefixLengthB = uPrefixLengthB; switch (cEdgeType) { case 'M': { assert(uPrefixLengthA > 0); assert(uPrefixLengthB > 0); const ProfPos &PPA = PA[uPrefixLengthA - 1]; const ProfPos &PPB = PB[uPrefixLengthB - 1]; const SCORE Score = DPM(uPrefixLengthA, uPrefixLengthB); const SCORE scoreMatch = ScoreProfPos2(PPA, PPB); SCORE scoreSM; if (1 == uPrefixLengthA && 1 == uPrefixLengthB) scoreSM = scoreMatch; else scoreSM = MINUS_INFINITY; SCORE scoreMM = MINUS_INFINITY; SCORE scoreDM = MINUS_INFINITY; SCORE scoreIM = MINUS_INFINITY; if (uPrefixLengthA > 1 && uPrefixLengthB > 1) scoreMM = DPM(uPrefixLengthA-1, uPrefixLengthB-1) + scoreMatch; if (uPrefixLengthA > 1) { SCORE scoreTransDM = PA[uPrefixLengthA-2].m_scoreGapClose; scoreDM = DPD(uPrefixLengthA-1, uPrefixLengthB-1) + scoreTransDM + scoreMatch; } if (uPrefixLengthB > 1) { SCORE scoreTransIM = PB[uPrefixLengthB-2].m_scoreGapClose; scoreIM = DPI(uPrefixLengthA-1, uPrefixLengthB-1) + scoreTransIM + scoreMatch; } if (EQ(scoreMM, Score)) cPrevEdgeType = 'M'; else if (EQ(scoreDM, Score)) cPrevEdgeType = 'D'; else if (EQ(scoreIM, Score)) cPrevEdgeType = 'I'; else if (EQ(scoreSM, Score)) cPrevEdgeType = 'S'; else Quit("TraceBack: failed to match M score=%g M=%g D=%g I=%g S=%g", Score, scoreMM, scoreDM, scoreIM, scoreSM); --uPrevPrefixLengthA; --uPrevPrefixLengthB; break; } case 'D': { assert(uPrefixLengthA > 0); const SCORE Score = DPD(uPrefixLengthA, uPrefixLengthB); SCORE scoreMD = MINUS_INFINITY; SCORE scoreDD = MINUS_INFINITY; SCORE scoreSD = MINUS_INFINITY; if (uPrefixLengthB == 0) { if (uPrefixLengthA == 1) scoreSD = PA[0].m_scoreGapOpen; else scoreSD = DPD(uPrefixLengthA - 1, 0); } if (uPrefixLengthA > 1) { const ProfPos &PPA = PA[uPrefixLengthA - 1]; SCORE scoreTransMD = PPA.m_scoreGapOpen; scoreMD = DPM(uPrefixLengthA-1, uPrefixLengthB) + scoreTransMD; scoreDD = DPD(uPrefixLengthA-1, uPrefixLengthB); } if (EQ(Score, scoreMD)) cPrevEdgeType = 'M'; else if (EQ(Score, scoreDD)) cPrevEdgeType = 'D'; else if (EQ(Score, scoreSD)) cPrevEdgeType = 'S'; else Quit("TraceBack: failed to match D"); --uPrevPrefixLengthA; break; } case 'I': { assert(uPrefixLengthB > 0); const SCORE Score = DPI(uPrefixLengthA, uPrefixLengthB); SCORE scoreMI = MINUS_INFINITY; SCORE scoreII = MINUS_INFINITY; SCORE scoreSI = MINUS_INFINITY; if (uPrefixLengthA == 0) { if (uPrefixLengthB == 1) scoreSI = PB[0].m_scoreGapOpen; else scoreSI = DPI(0, uPrefixLengthB - 1); } if (uPrefixLengthB > 1) { const ProfPos &PPB = PB[uPrefixLengthB - 1]; SCORE scoreTransMI = PPB.m_scoreGapOpen; scoreMI = DPM(uPrefixLengthA, uPrefixLengthB-1) + scoreTransMI; scoreII = DPI(uPrefixLengthA, uPrefixLengthB-1); } if (EQ(Score, scoreMI)) cPrevEdgeType = 'M'; else if (EQ(Score, scoreII)) cPrevEdgeType = 'I'; else if (EQ(Score, scoreSI)) cPrevEdgeType = 'S'; else Quit("TraceBack: failed to match I"); --uPrevPrefixLengthB; break; } default: assert(false); } #if TRACE Log("Edge %c%c%u.%u", cPrevEdgeType, cEdgeType, uPrefixLengthA, uPrefixLengthB); Log("\n"); #endif cEdgeType = cPrevEdgeType; uPrefixLengthA = uPrevPrefixLengthA; uPrefixLengthB = uPrevPrefixLengthB; } return scoreMax; }