// $Id: // FORESTER -- software libraries and applications // for evolutionary biology research and applications. // // Copyright (C) 2008-2009 Christian M. Zmasek // Copyright (C) 2008-2009 Burnham Institute for Medical Research // All rights reserved // // This library is free software; you can redistribute it and/or // modify it under the terms of the GNU Lesser General Public // License as published by the Free Software Foundation; either // version 2.1 of the License, or (at your option) any later version. // // This library is distributed in the hope that it will be useful, // but WITHOUT ANY WARRANTY; without even the implied warranty of // MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU // Lesser General Public License for more details. // // You should have received a copy of the GNU Lesser General Public // License along with this library; if not, write to the Free Software // Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA // // Contact: phylosoft @ gmail . com // WWW: www.phylosoft.org package org.forester.application; import java.io.File; import java.io.IOException; import java.util.ArrayList; import java.util.Date; import java.util.List; import org.forester.io.parsers.PhylogenyParser; import org.forester.io.parsers.phyloxml.PhyloXmlParser; import org.forester.io.writers.PhylogenyWriter; import org.forester.phylogeny.Phylogeny; import org.forester.phylogeny.PhylogenyMethods; import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory; import org.forester.phylogeny.factories.PhylogenyFactory; import org.forester.sdi.SDIR; import org.forester.util.CommandLineArguments; import org.forester.util.ForesterUtil; public class sdi_r { final static private String HELP_OPTION_1 = "help"; final static private String HELP_OPTION_2 = "h"; final static private String MIN_MAPPING_COST_OPTION = "ml"; final static private String MIN_DUPS_OPTION = "md"; final static private String MIN_HEIGHT_OPTION = "mh"; final static private String PRG_NAME = "sdi_r"; final static private String PRG_VERSION = "1.11"; final static private String PRG_DATE = "2009.06.19"; final static private String E_MAIL = "czmasek@burnham.org"; final static private String WWW = "www.phylosoft.org"; // How many resulting trees "main" should return/display. private final static int TREES_TO_RETURN = 5; public static void main( final String args[] ) { ForesterUtil.printProgramInformation( PRG_NAME, PRG_VERSION, PRG_DATE, E_MAIL, WWW ); CommandLineArguments cla = null; try { cla = new CommandLineArguments( args ); } catch ( final Exception e ) { ForesterUtil.fatalError( PRG_NAME, e.getMessage() ); } if ( cla.isOptionSet( HELP_OPTION_1 ) || cla.isOptionSet( HELP_OPTION_2 ) || ( args.length == 0 ) ) { printHelp(); System.exit( 0 ); } if ( ( args.length < 3 ) || ( cla.getNumberOfNames() != 2 ) ) { System.out.println(); System.out.println( "[" + PRG_NAME + "] incorrect number of arguments" ); System.out.println(); printHelp(); System.exit( -1 ); } final List allowed_options = new ArrayList(); allowed_options.add( MIN_MAPPING_COST_OPTION ); allowed_options.add( MIN_DUPS_OPTION ); allowed_options.add( MIN_HEIGHT_OPTION ); final String dissallowed_options = cla.validateAllowedOptionsAsString( allowed_options ); if ( dissallowed_options.length() > 0 ) { ForesterUtil.fatalError( PRG_NAME, "unknown option(s): " + dissallowed_options ); } final File outfile = new File( "sdir_outfile.xml" ); if ( outfile.exists() ) { ForesterUtil.fatalError( PRG_NAME, "outfile \"" + outfile + "\" already exists" ); } final File gene_tree_file = cla.getFile( 0 ); final File species_tree_file = cla.getFile( 1 ); boolean minimize_cost = false; if ( cla.isOptionSet( MIN_MAPPING_COST_OPTION ) ) { minimize_cost = true; } boolean minimize_sum_of_dup = false; if ( cla.isOptionSet( MIN_DUPS_OPTION ) ) { minimize_sum_of_dup = true; } boolean minimize_height = false; if ( cla.isOptionSet( MIN_HEIGHT_OPTION ) ) { minimize_height = true; } int r = 0; Phylogeny[] gene_trees = null; Phylogeny species_tree = null; if ( minimize_cost && minimize_sum_of_dup ) { minimize_sum_of_dup = false; } final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance(); try { final PhylogenyParser pp = new PhyloXmlParser(); species_tree = factory.create( species_tree_file, pp )[ 0 ]; } catch ( final IOException e ) { ForesterUtil.fatalError( PRG_NAME, "failed to read species tree [" + species_tree_file + "]: " + e.getLocalizedMessage() ); } if ( !species_tree.isRooted() ) { ForesterUtil.fatalError( PRG_NAME, "species tree [" + species_tree_file + "] is not rooted" ); } try { final PhylogenyParser pp = new PhyloXmlParser(); gene_trees = factory.create( gene_tree_file, pp ); } catch ( final IOException e ) { ForesterUtil.fatalError( PRG_NAME, "failed to read gene trees [" + gene_tree_file + "]: " + e.getLocalizedMessage() ); } // Removes from gene_tree all species not found in species_tree. int gene_tree_counter = 0; final List all_result_trees = new ArrayList(); for( final Phylogeny gene_tree : gene_trees ) { r = PhylogenyMethods.taxonomyBasedDeletionOfExternalNodes( species_tree, gene_tree ); ForesterUtil.programMessage( PRG_NAME, "Removed " + r + " external nodes from gene tree" ); final SDIR sdiunrooted = new SDIR(); final long start_time = new Date().getTime(); Phylogeny[] result_trees = null; try { result_trees = sdiunrooted.infer( gene_tree, species_tree, minimize_cost, minimize_sum_of_dup, minimize_height, true, sdi_r.TREES_TO_RETURN ); } catch ( final Exception e ) { ForesterUtil.fatalError( PRG_NAME, e.getLocalizedMessage() ); } final long time_req = new Date().getTime() - start_time; if ( minimize_cost ) { ForesterUtil.programMessage( PRG_NAME, "Rooted by minimizing mapping cost L" ); if ( minimize_height ) { ForesterUtil.programMessage( PRG_NAME, "Selected tree(s) with minimal height out of resulting trees" ); } ForesterUtil.programMessage( PRG_NAME, "Number differently rooted trees minimizing criterion : " + sdiunrooted.getCount() ); ForesterUtil.programMessage( PRG_NAME, "Minimal cost : " + sdiunrooted.getMinimalMappingCost() ); ForesterUtil.programMessage( PRG_NAME, "Minimal duplications : " + sdiunrooted.getMinimalDuplications() ); if ( minimize_height ) { ForesterUtil.programMessage( PRG_NAME, "Phylogeny height : " + ForesterUtil.FORMATTER_06.format( sdiunrooted.getMinimalTreeHeight() ) ); ForesterUtil.programMessage( PRG_NAME, "Difference in subtree heights : " + ForesterUtil.FORMATTER_06.format( sdiunrooted.getMinimalDiffInSubTreeHeights() ) ); } } else if ( minimize_sum_of_dup ) { ForesterUtil.programMessage( PRG_NAME, "Rooted by minimizing sum of duplications" ); if ( minimize_height ) { ForesterUtil.programMessage( PRG_NAME, "Selected tree(s) with minimal height out of resulting trees" ); } ForesterUtil.programMessage( PRG_NAME, "Number differently rooted trees minimizing criterion : " + sdiunrooted.getCount() ); ForesterUtil.programMessage( PRG_NAME, "Minimal duplications : " + sdiunrooted.getMinimalDuplications() ); if ( minimize_height ) { ForesterUtil.programMessage( PRG_NAME, "Phylogeny height : " + ForesterUtil.FORMATTER_06.format( sdiunrooted .getMinimalTreeHeight() ) ); ForesterUtil.programMessage( PRG_NAME, "Difference in subtree heights : " + ForesterUtil.FORMATTER_06.format( sdiunrooted .getMinimalDiffInSubTreeHeights() ) ); } } else if ( minimize_height ) { ForesterUtil.programMessage( PRG_NAME, "Rooted by minimizing tree height (midpoint rooting)." ); ForesterUtil.programMessage( PRG_NAME, "Minimal tree height : " + ForesterUtil.FORMATTER_06.format( sdiunrooted.getMinimalTreeHeight() ) ); ForesterUtil.programMessage( PRG_NAME, "Minimal difference in subtree heights: " + ForesterUtil.FORMATTER_06.format( sdiunrooted.getMinimalDiffInSubTreeHeights() ) ); ForesterUtil.programMessage( PRG_NAME, "Duplications in midpoint rooted tree : " + sdiunrooted.getMinimalDuplications() ); } else { ForesterUtil.programMessage( PRG_NAME, "No (re) rooting was performed." ); ForesterUtil.programMessage( PRG_NAME, "Duplications in tree: " + sdiunrooted.getMinimalDuplications() ); } ForesterUtil.programMessage( PRG_NAME, "Time requirement (minus I/O) : " + time_req + "ms" ); for( int i = 0; i < result_trees.length; ++i ) { final String name = result_trees[ i ].getName(); if ( ForesterUtil.isEmpty( name ) ) { result_trees[ i ].setName( "SDIR result [gene tree + " + gene_tree_counter + "]" + " " + i ); } else { result_trees[ i ].setName( name + " SDIR result [gene tree + " + gene_tree_counter + "]" + " " + i ); } all_result_trees.add( result_trees[ i ] ); } ++gene_tree_counter; } // for( final Phylogeny gene_tree : gene_trees ) try { final PhylogenyWriter w = new PhylogenyWriter(); w.toPhyloXML( outfile, all_result_trees, 0, ForesterUtil.LINE_SEPARATOR ); } catch ( final IOException e ) { ForesterUtil.fatalError( PRG_NAME, "failure to write output to [" + outfile + "]: " + e.getLocalizedMessage() ); } ForesterUtil.programMessage( PRG_NAME, "Wrote: " + outfile ); ForesterUtil.programMessage( PRG_NAME, "OK." ); } private static void printHelp() { System.out.println( "Usage: " + PRG_NAME + " \"" ); System.out.println( "\nOptions:" ); System.out.println( " -" + MIN_MAPPING_COST_OPTION + " to root by minimizing the mapping cost L (and also the sum of duplications)" ); System.out.println( " -" + MIN_DUPS_OPTION + " to root by minimizing the sum of duplications" ); System.out.println( " -" + MIN_HEIGHT_OPTION + " to root by minimizing tree height (can be used together with -" + MIN_MAPPING_COST_OPTION + " or -" + MIN_DUPS_OPTION + ")" ); System.out.println( "" ); } }