// $Id: // forester -- software libraries and applications // for genomics and evolutionary biology research. // // Copyright (C) 2010 Christian M Zmasek // Copyright (C) 2010 Sanford-Burnham Medical Research Institute // All rights reserved // // This library is free software; you can redistribute it and/or // modify it under the terms of the GNU Lesser General Public // License as published by the Free Software Foundation; either // version 2.1 of the License, or (at your option) any later version. // // This library is distributed in the hope that it will be useful, // but WITHOUT ANY WARRANTY; without even the implied warranty of // MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU // Lesser General Public License for more details. // // You should have received a copy of the GNU Lesser General Public // License along with this library; if not, write to the Free Software // Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA // // Contact: phylosoft @ gmail . com // WWW: https://sites.google.com/site/cmzmasek/home/software/forester package org.forester.evoinference.tools; import java.util.Random; import org.forester.msa.BasicMsa; import org.forester.msa.Msa; public class BootstrapResampler { private static void copyIdentifiers( final Msa msa, final Msa new_msa ) { for( int i = 0; i < msa.getNumberOfSequences(); ++i ) { new_msa.setIdentifier( i, msa.getIdentifier( i ) ); } } private static void preconditionCheck( final Msa msa, final int n ) { if ( msa.getLength() < 2 ) { throw new IllegalArgumentException( "Msa length cannot be smaller than two for bootstrap resampling" ); } if ( msa.getNumberOfSequences() < 1 ) { throw new IllegalArgumentException( "Attempt to bootstrap resample empty multiple sequence alignment" ); } if ( n < 1 ) { throw new IllegalArgumentException( "Number of bootstrap resamples cannot be zero or negative" ); } } private static void preconditionCheck( final int length, final int n ) { if ( length < 2 ) { throw new IllegalArgumentException( "Msa length cannot be smaller than two for bootstrap resampling" ); } if ( n < 1 ) { throw new IllegalArgumentException( "Number of bootstrap resamples cannot be zero or negative" ); } } public static Msa[] resample( final Msa msa, final int n, final long seed ) { preconditionCheck( msa, n ); final Random random = new Random( seed ); final Msa[] msas = new Msa[ n ]; for( int i = 0; i < n; ++i ) { final Msa new_msa = new BasicMsa( msa.getNumberOfSequences(), msa.getLength(), msa.getType() ); msas[ i ] = new_msa; copyIdentifiers( msa, new_msa ); for( int col = 0; col < msa.getLength(); ++col ) { final int random_col = random.nextInt( msa.getLength() ); for( int row = 0; row < msa.getNumberOfSequences(); ++row ) { new_msa.setResidueAt( row, col, msa.getResidueAt( row, random_col ) ); } } } return msas; } public static int[][] createResampledColumnPositions( final int length, final int n, final long seed ) { preconditionCheck( length, n ); final Random random = new Random( seed ); final int[][] columns = new int[ n ][ length ]; for( int i = 0; i < n; ++i ) { for( int col = 0; col < length; ++col ) { columns[ i ][ col ] = random.nextInt( length ); } } return columns; } }