/*
* Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
* Copyright (C) $$Year-Rel$$ The Jalview Authors
*
* This file is part of Jalview.
*
* Jalview is free software: you can redistribute it and/or
* modify it under the terms of the GNU General Public License
* as published by the Free Software Foundation, either version 3
* of the License, or (at your option) any later version.
*
* Jalview is distributed in the hope that it will be useful, but
* WITHOUT ANY WARRANTY; without even the implied warranty
* of MERCHANTABILITY or FITNESS FOR A PARTICULAR
* PURPOSE. See the GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with Jalview. If not, see .
* The Jalview Authors are detailed in the 'AUTHORS' file.
*/
/* Author: Lauren Michelle Lui
* Methods are based on RALEE methods http://personalpages.manchester.ac.uk/staff/sam.griffiths-jones/software/ralee/
* Additional Author: Jan Engelhart (2011) - Structure consensus and bug fixing
* Additional Author: Anne Menard (2012) - Pseudoknot support and secondary structure consensus
* */
package jalview.analysis;
import jalview.analysis.SecStrConsensus.SimpleBP;
import jalview.datamodel.SequenceFeature;
import jalview.util.MessageManager;
import java.util.ArrayList;
import java.util.HashMap;
import java.util.Hashtable;
import java.util.List;
import java.util.Map;
import java.util.Stack;
public class Rna
{
/**
* Answers true if the character is a valid open pair rna secondary structure
* symbol. Currently accepts A-Z, ([{<
*
* @param c
* @return
*/
public static boolean isOpeningParenthesis(char c)
{
return ('A' <= c && c <= 'Z' || c == '(' || c == '[' || c == '{'
|| c == '<');
}
/**
* Answers true if the string is a valid open pair rna secondary structure
* symbol. Currently accepts A-Z, ([{<
*
* @param s
* @return
*/
public static boolean isOpeningParenthesis(String s)
{
return s != null && s.length() == 1
&& isOpeningParenthesis(s.charAt(0));
}
/**
* Answers true if the character is a valid close pair rna secondary structure
* symbol. Currently accepts a-z, )]}>
*
* @param c
* @return
*/
public static boolean isClosingParenthesis(char c)
{
return ('a' <= c && c <= 'z' || c == ')' || c == ']' || c == '}'
|| c == '>');
}
/**
* Answers true if the string is a valid close pair rna secondary structure
* symbol. Currently accepts a-z, )]}>
*
* @param s
* @return
*/
public static boolean isClosingParenthesis(String s)
{
return s != null && s.length() == 1
&& isClosingParenthesis(s.charAt(0));
}
/**
* Returns the matching open pair symbol for the given closing symbol.
* Currently returns A-Z for a-z, or ([{< for )]}>, or the input symbol if it
* is not a valid closing symbol.
*
* @param c
* @return
*/
public static char getMatchingOpeningParenthesis(char c)
{
if ('a' <= c && c <= 'z')
{
return (char) (c + 'A' - 'a');
}
switch (c)
{
case ')':
return '(';
case ']':
return '[';
case '}':
return '{';
case '>':
return '<';
default:
return c;
}
}
/**
* Based off of RALEE code ralee-get-base-pairs. Keeps track of open bracket
* positions in "stack" vector. When a close bracket is reached, pair this
* with the last matching element in the "stack" vector and store in "pairs"
* vector. Remove last element in the "stack" vector. Continue in this manner
* until the whole string is processed. Parse errors are thrown as exceptions
* wrapping the error location - position of the first unmatched closing
* bracket, or string length if there is an unmatched opening bracket.
*
* @param line
* Secondary structure line of an RNA Stockholm file
* @return
* @throw {@link WUSSParseException}
*/
protected static List getSimpleBPs(CharSequence line)
throws WUSSParseException
{
Hashtable> stacks = new Hashtable>();
List pairs = new ArrayList();
int i = 0;
while (i < line.length())
{
char base = line.charAt(i);
if (isOpeningParenthesis(base))
{
if (!stacks.containsKey(base))
{
stacks.put(base, new Stack());
}
stacks.get(base).push(i);
}
else if (isClosingParenthesis(base))
{
char opening = getMatchingOpeningParenthesis(base);
if (!stacks.containsKey(opening))
{
throw new WUSSParseException(MessageManager.formatMessage(
"exception.mismatched_unseen_closing_char", new String[]
{ String.valueOf(base) }), i);
}
Stack stack = stacks.get(opening);
if (stack.isEmpty())
{
// error whilst parsing i'th position. pass back
throw new WUSSParseException(MessageManager.formatMessage(
"exception.mismatched_closing_char", new String[]
{ String.valueOf(base) }), i);
}
int temp = stack.pop();
pairs.add(new SimpleBP(temp, i));
}
i++;
}
for (char opening : stacks.keySet())
{
Stack stack = stacks.get(opening);
if (!stack.empty())
{
/*
* we have an unmatched opening bracket; report error as at
* i (length of input string)
*/
throw new WUSSParseException(MessageManager.formatMessage(
"exception.mismatched_opening_char", new String[]
{ String.valueOf(opening), String.valueOf(stack.pop()) }),
i);
}
}
return pairs;
}
/**
* Function to get the end position corresponding to a given start position
*
* @param indice
* - start position of a base pair
* @return - end position of a base pair
*/
/*
* makes no sense at the moment :( public int findEnd(int indice){ //TODO:
* Probably extend this to find the start to a given end? //could be done by
* putting everything twice to the hash ArrayList pair = new
* ArrayList(); return pairHash.get(indice); }
*/
/**
* Answers true if the character is a recognised symbol for RNA secondary
* structure. Currently accepts a-z, A-Z, ()[]{}<>.
*
* @param c
* @return
*/
public static boolean isRnaSecondaryStructureSymbol(char c)
{
return isOpeningParenthesis(c) || isClosingParenthesis(c);
}
/**
* Answers true if the string is a recognised symbol for RNA secondary
* structure. Currently accepts a-z, A-Z, ()[]{}<>.
*
* @param s
* @return
*/
public static boolean isRnaSecondaryStructureSymbol(String s)
{
return isOpeningParenthesis(s) || isClosingParenthesis(s);
}
/**
* Translates a string to RNA secondary structure representation. Returns the
* string with any non-SS characters changed to spaces. Accepted characters
* are a-z, A-Z, and (){}[]<> brackets.
*
* @param ssString
* @return
*/
public static String getRNASecStrucState(String ssString)
{
if (ssString == null)
{
return null;
}
StringBuilder result = new StringBuilder(ssString.length());
for (int i = 0; i < ssString.length(); i++)
{
char c = ssString.charAt(i);
result.append(isRnaSecondaryStructureSymbol(c) ? c : " ");
}
return result.toString();
}
/**
* Answers true if the base-pair is either a Watson-Crick (A:T/U, C:G) or a
* wobble (G:T/U) pair (either way round), else false
*
* @param first
* @param second
* @return
*/
public static boolean isCanonicalOrWobblePair(char first, char second)
{
if (first > 'Z')
{
first -= 32;
}
if (second > 'Z')
{
second -= 32;
}
switch (first)
{
case 'A':
switch (second)
{
case 'T':
case 'U':
return true;
}
break;
case 'C':
switch (second)
{
case 'G':
return true;
}
break;
case 'T':
case 'U':
switch (second)
{
case 'A':
case 'G':
return true;
}
break;
case 'G':
switch (second)
{
case 'C':
case 'T':
case 'U':
return true;
}
break;
}
return false;
}
/**
* Answers true if the base-pair is Watson-Crick - (A:T/U or C:G, either way
* round), else false
*
* @param first
* @param second
* @return
*/
public static boolean isCanonicalPair(char first, char second)
{
if (first > 'Z')
{
first -= 32;
}
if (second > 'Z')
{
second -= 32;
}
switch (first)
{
case 'A':
switch (second)
{
case 'T':
case 'U':
return true;
}
break;
case 'G':
switch (second)
{
case 'C':
return true;
}
break;
case 'C':
switch (second)
{
case 'G':
return true;
}
break;
case 'T':
case 'U':
switch (second)
{
case 'A':
return true;
}
break;
}
return false;
}
/**
* Returns the matching close pair symbol for the given opening symbol.
* Currently returns a-z for A-Z, or )]}> for ([{<, or the input symbol if it
* is not a valid opening symbol.
*
* @param c
* @return
*/
public static char getMatchingClosingParenthesis(char c)
{
if ('A' <= c && c <= 'Z')
{
return (char) (c + 'a' - 'A');
}
switch (c)
{
case '(':
return ')';
case '[':
return ']';
case '{':
return '}';
case '<':
return '>';
default:
return c;
}
}
public static SequenceFeature[] getHelixMap(CharSequence rnaAnnotation)
throws WUSSParseException
{
List result = new ArrayList();
int helix = 0; // Number of helices/current helix
int lastopen = 0; // Position of last open bracket reviewed
int lastclose = 9999999; // Position of last close bracket reviewed
Map helices = new HashMap();
// Keep track of helix number for each position
// Go through each base pair and assign positions a helix
List bps = getSimpleBPs(rnaAnnotation);
for (SimpleBP basePair : bps)
{
final int open = basePair.getBP5();
final int close = basePair.getBP3();
// System.out.println("open " + open + " close " + close);
// System.out.println("lastclose " + lastclose + " lastopen " + lastopen);
// we're moving from right to left based on closing pair
/*
* catch things like <<..>>..<<..>> |
*/
if (open > lastclose)
{
helix++;
}
/*
* catch things like <<..<<..>>..<<..>>>> |
*/
int j = bps.size() - 1;
while (j >= 0)
{
int popen = bps.get(j).getBP5();
// System.out.println("j " + j + " popen " + popen + " lastopen "
// +lastopen + " open " + open);
if ((popen < lastopen) && (popen > open))
{
if (helices.containsValue(popen)
&& ((helices.get(popen)) == helix))
{
continue;
}
else
{
helix++;
break;
}
}
j -= 1;
}
// Put positions and helix information into the hashtable
helices.put(open, helix);
helices.put(close, helix);
// Record helix as featuregroup
result.add(new SequenceFeature("RNA helix", "", open, close,
String.valueOf(helix)));
lastopen = open;
lastclose = close;
}
return result.toArray(new SequenceFeature[result.size()]);
}
}