/* * Jalview - A Sequence Alignment Editor and Viewer * Copyright (C) 2006 AM Waterhouse, J Procter, G Barton, M Clamp, S Searle * * This program is free software; you can redistribute it and/or * modify it under the terms of the GNU General Public License * as published by the Free Software Foundation; either version 2 * of the License, or (at your option) any later version. * * This program is distributed in the hope that it will be useful, * but WITHOUT ANY WARRANTY; without even the implied warranty of * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the * GNU General Public License for more details. * * You should have received a copy of the GNU General Public License * along with this program; if not, write to the Free Software * Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA */ package jalview.datamodel; import java.util.Vector; public abstract class CigarBase { /** * Base class for compact idiosyncratic representation of gaps and aligned residues * Regards to Tom Oldfield for his DynamicArray class. * 17th July 2006 * Not thread safe. */ public CigarBase() { // nothing to be done (probably) } protected int length = 0; protected int _inc_length = 10; // extension range for addition of new operations protected char[] operation = null; protected int[] range = null; /** * Range of Hidden residues in seq (translated as deleted in seq) */ public static final char D = 'D'; /** * Range of insertions to seq */ public static final char I = 'I'; /** * Range of aligned residues */ public static final char M = 'M'; static protected final char _case_shift = 'a' - 'A'; /** * Ugly function to get edited sequence string, start and end symbol positions and the deletion regions as an array of int pairs * May return null for an empty cigar string. * May return null for deletion ranges if there are none. * @param reference - the symbol sequence to apply the cigar operations to (or null if no sequence) * @param GapChar - the symbol to use for Insert operations * @return Object[] { String, int[] {start, startcol, end, endcol}, int[][3] {start, end, col} or null} the gapped sequence, first and last residue index, and the deletion ranges on the reference sequence */ public Object[] getSequenceAndDeletions(String reference, char GapChar) { int rlength=0; int[][] deletions = new int[length][]; int[][] trunc_deletions = null; StringBuffer sq = new StringBuffer(); int cursor = 0, alcursor=0,start = 0, startpos=0, end = 0, endpos=0, delcount = -1; boolean consecutive_del = false; if (length == 0) { return null; } if (reference!=null) rlength=reference.length(); boolean modstart = true; for (int i = 0; i < length; i++) { switch (operation[i]) { case D: if (!consecutive_del) { deletions[++delcount] = new int[] { cursor, 0, alcursor}; } cursor += range[i]; deletions[delcount][1] = cursor - 1; consecutive_del = true; break; case I: consecutive_del = false; for (int r = 0; r < range[i]; r++) { sq.append(GapChar); alcursor++; } break; case M: consecutive_del = false; if (modstart) { start = cursor; startpos=alcursor; modstart = false; } if (reference!=null) { int sbend = cursor+range[i]; if (sbend>rlength) { sq.append(reference.substring(cursor, rlength)); while (sbend-- >= rlength) { sq.append(GapChar); } } else { sq.append(reference.substring(cursor, sbend)); } } alcursor+=range[i]; cursor += range[i]; end = cursor - 1; endpos = alcursor; break; default: throw new Error("Unknown SeqCigar operation '" + operation[i] + "'"); } } if (++delcount > 0) { trunc_deletions = new int[delcount][]; System.arraycopy(deletions, 0, trunc_deletions, 0, delcount); } deletions = null; return new Object[] { ((reference!=null) ? sq.toString() : null), new int[] { start, startpos, end, endpos}, trunc_deletions}; } protected void compact_operations() { int i=1; if (operation==null) return; char last = operation[0]; while (i0) { System.arraycopy(range, i + 1, range, i, r); System.arraycopy(operation, i + 1, operation, i, r); } length--; } else { last = operation[i++]; } } } /** * turn a cigar string into a series of operation range pairs * @param cigarString String * @return object[] {char[] operation, int[] range} * @throws java.lang.Exception for improperly formated cigar strings or ones with unknown operations */ public static Object[] parseCigarString(String cigarString) throws Exception { int ops = 0; for (int i = 0, l = cigarString.length(); i < l; i++) { char c = cigarString.charAt(i); if (c == M || c == (M - _case_shift) || c == I || c == (I - _case_shift) || c == D || c == (D - _case_shift)) { ops++; } } char[] operation = new char[ops]; int[] range = new int[ops]; int op = 0; int i = 0, l = cigarString.length(); while (i < l) { char c; int j = i; do { c = cigarString.charAt(j++); } while (c >= '0' && c <= '9' && j < l); if (j >= l && c >= '0' && c <= '9') { throw new Exception("Unterminated cigar string."); } try { String rangeint = cigarString.substring(i, j - 1); range[op] = Integer.parseInt(rangeint); i = j; } catch (Exception e) { throw new Error("Implementation bug in parseCigarString"); } if (c >= 'a' && c <= 'z') { c -= _case_shift; } if ( (c == M || c == I || c == D)) { operation[op++] = c; } else { throw new Exception("Unexpected operation '" + c + "' in cigar string (position " + i + " in '" + cigarString + "'"); } } return new Object[] { operation, range}; } /** * add an operation to cigar string * @param op char * @param range int */ public void addOperation(char op, int range) { if (op >= 'a' && op <= 'z') { op -= _case_shift; } if (op != M && op != D && op != I) { throw new Error("Implementation error. Invalid operation string."); } if (range<=0) throw new Error("Invalid range string (must be non-zero positive number)"); int lngth = 0; if (operation == null) { this.operation = new char[_inc_length]; this.range = new int[_inc_length]; } if (length + 1 == operation.length) { char[] ops = this.operation; this.operation = new char[length + 1 + _inc_length]; System.arraycopy(ops, 0, this.operation, 0, length); ops = null; int[] rng = this.range; this.range = new int[length + 1 + _inc_length]; System.arraycopy(rng, 0, this.range, 0, length); rng = null; } if ((length>0) && (operation[length-1]==op)) length--; // modify existing operation. else this.range[length]=0; // reset range this.operation[length] = op; this.range[length++] += range; } /** * semi-efficient insert an operation on the current cigar string set at column pos (from 1) * NOTE: Insertion operations simply extend width of cigar result - affecting registration of alignment * Deletion ops will shorten length of result - and affect registration of alignment * Match ops will also affect length of result - affecting registration of alignment * (ie "10M".insert(4,I,3)->"4M3I3M") - (replace?) * (ie "10M".insert(4,D,3)->"4M3D3M") - (shortens alignment) * (ie "5I5M".insert(4,I,3)->"8I5M") - real insertion * (ie "5I5M".insert(4,D,3)->"4I2D3M") - shortens aligment - I's are removed, Ms changed to Ds * (ie "10M".insert(4,M,3)->"13M") - lengthens - Is changed to M, Ds changed to M. * (ie "5I5M".insert(4,M,3)->"4I8M") - effectively shifts sequence left by 1 residue and extends it by 3 * ( "10D5M".insert(-1,M,3)->"3M7D5M") * ( "10D5M".insert(0,M,3)->"7D8M") * ( "10D5M".insert(1,M,3)->"10D8M") * * ( "1M10D5M".insert(0,M,3)->"1M10D8M") * ( "1M10D5M".insert(1,M,3)->" * * if pos is beyond width - I operations are added before the operation * @param pos int -1, 0-length of visible region, or greater to append new ops (with insertions in between) * @param op char * @param range int public void addOperationAt(int pos, char op, int range) { int cursor = -1; // mark the position for the current operation being edited. int o = 0; boolean last_d = false; // previous op was a deletion. if (pos < -1) throw new Error("pos<-1 is not supported."); while (o0) addInsertion(pos-cursor); // then just add the new operation. Regardless of what it is. addOperation(op, range); } else { int diff = pos - cursor; int e_length = length-o; // new edit operation array length. // diff<0 - can only happen before first insertion or match. - affects op and all following // dif==0 - only when at first position of existing op - // diff>0 - must preserve some existing operations int[] e_range = new int[e_length]; System.arraycopy(this.range, o, e_range, 0, e_length); char[] e_op = new char[e_length]; System.arraycopy(this.operation, o, e_op, 0, e_length); length = o; // can now use add_operation to extend list. int e_o=0; // current operation being edited. switch (op) { case M: switch (e_op[e_o]) { case M: if (last_d && diff <= 0) { // reduce D's, if possible if (range<=this.range[o-1]) { this.range[o - 1] -= range; } else { this.range[o-1]=0; } if (this.range[o-1]==0) o--; // lose this op. } e_range[e_o] += range; // just add more matched residues break; case I: // change from insertion to match if (last_d && diff<=0) { // reduce D's, if possible if (range<=this.range[o-1]) { this.range[o - 1] -= range; } else { this.range[o-1]=0; } if (this.range[o-1]==0) o--; // lose this op. } e_range[e_o] break; default: throw new Inp } break; case I: break; case D: } break; default: throw new Error("Implementation Error: Unknown operation in addOperation!"); } // finally, add remaining ops. while (e_oend) throw new Error("Implementation Error: deleteRange out of bounds: start must be non-negative and less than end."); // find beginning int cursor = 0; // mark the position for the current operation being edited. int rlength=1+end-start; // number of positions to delete int oldlen=length; int o = 0; boolean editing=false; char[] oldops = operation; int[] oldrange = range; length=0; operation = null; range = null; compact_operations(); while (o0) { if (oldops[o] == D) { // absorbed into new deleted region. addDeleted(oldrange[o++]); continue; } int remain = oldrange[o]; // number of op characters left to edit if (!editing) { if ( (cursor + remain) <= start) { addOperation(oldops[o],oldrange[o]); cursor+=oldrange[o++]; continue; // next operation } editing=true; // add operations before hidden region if (start-cursor>0) { addOperation(oldops[o], start- cursor); remain -= start - cursor; } } // start inserting new ops if (o0 && remain>0) { switch (oldops[o]) { case M: if (rlength>remain) { addDeleted(remain); deleted+=remain; } else { deleted+=rlength; addDeleted(rlength); if (remain-rlength>0) this.addOperation(M,remain-rlength); // add remaining back. rlength=0; remain=0; } break; case I: if (remain-rlength>0) { // only remove some gaps addInsertion(remain-rlength); rlength=0; } break; case D: throw new Error("Implementation error."); // do nothing; default: throw new Error("Implementation Error! Unknown operation '"+oldops[o]+"'"); } rlength-=remain; remain = oldrange[++o]; // number of op characters left to edit } } // add remaining while (o