/*
* Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
* Copyright (C) $$Year-Rel$$ The Jalview Authors
*
* This file is part of Jalview.
*
* Jalview is free software: you can redistribute it and/or
* modify it under the terms of the GNU General Public License
* as published by the Free Software Foundation, either version 3
* of the License, or (at your option) any later version.
*
* Jalview is distributed in the hope that it will be useful, but
* WITHOUT ANY WARRANTY; without even the implied warranty
* of MERCHANTABILITY or FITNESS FOR A PARTICULAR
* PURPOSE. See the GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with Jalview. If not, see .
* The Jalview Authors are detailed in the 'AUTHORS' file.
*/
package jalview.ext.ensembl;
import jalview.datamodel.AlignmentI;
import java.io.BufferedReader;
import java.io.IOException;
import java.net.MalformedURLException;
import java.net.URL;
import java.util.Arrays;
import java.util.List;
import org.json.simple.JSONObject;
import org.json.simple.parser.JSONParser;
import org.json.simple.parser.ParseException;
/**
* A client for the Ensembl lookup REST endpoint, used to find the gene
* identifier given a gene, transcript or protein identifier.
*
* @author gmcarstairs
*/
public class EnsemblLookup extends EnsemblRestClient
{
/**
* Default constructor (to use rest.ensembl.org)
*/
public EnsemblLookup()
{
super();
}
/**
* Constructor given the target domain to fetch data from
*
* @param
*/
public EnsemblLookup(String d)
{
super(d);
}
@Override
public String getDbName()
{
return "ENSEMBL";
}
@Override
public AlignmentI getSequenceRecords(String queries) throws Exception
{
return null;
}
@Override
protected URL getUrl(List ids) throws MalformedURLException
{
String identifier = ids.get(0);
return getUrl(identifier, null);
}
/**
* Gets the url for lookup of the given identifier, optionally with objectType
* also specified in the request
*
* @param identifier
* @param objectType
* @return
*/
protected URL getUrl(String identifier, String objectType)
{
String url = getDomain() + "/lookup/id/" + identifier
+ CONTENT_TYPE_JSON;
if (objectType != null)
{
url += "&" + OBJECT_TYPE + "=" + objectType;
}
try
{
return new URL(url);
} catch (MalformedURLException e)
{
return null;
}
}
@Override
protected boolean useGetRequest()
{
return true;
}
@Override
protected String getRequestMimeType(boolean multipleIds)
{
return "application/json";
}
@Override
protected String getResponseMimeType()
{
return "application/json";
}
/**
* Returns the gene id related to the given identifier, which may be for a
* gene, transcript or protein
*
* @param identifier
* @return
*/
public String getGeneId(String identifier)
{
return getGeneId(identifier, null);
}
/**
* Returns the gene id related to the given identifier (which may be for a
* gene, transcript or protein)
*
* @param identifier
* @param objectType
* @return
*/
public String getGeneId(String identifier, String objectType)
{
List ids = Arrays.asList(new String[] { identifier });
BufferedReader br = null;
try
{
URL url = getUrl(identifier, objectType);
if (url != null)
{
br = getHttpResponse(url, ids);
}
return br == null ? null : parseResponse(br);
} catch (IOException e)
{
// ignore
return null;
} finally
{
if (br != null)
{
try
{
br.close();
} catch (IOException e)
{
// ignore
}
}
}
}
/**
* Parses the JSON response and returns the gene identifier, or null if not
* found. If the returned object_type is Gene, returns the id, if Transcript
* returns the Parent. If it is Translation (peptide identifier), then the
* Parent is the transcript identifier, so we redo the search with this value.
*
* @param br
* @return
* @throws IOException
*/
protected String parseResponse(BufferedReader br) throws IOException
{
String geneId = null;
JSONParser jp = new JSONParser();
try
{
JSONObject val = (JSONObject) jp.parse(br);
String type = val.get(OBJECT_TYPE).toString();
if (OBJECT_TYPE_GENE.equalsIgnoreCase(type))
{
// got the gene - just returns its id
geneId = val.get(ID).toString();
}
else if (OBJECT_TYPE_TRANSCRIPT.equalsIgnoreCase(type))
{
// got the transcript - return its (Gene) Parent
geneId = val.get(PARENT).toString();
}
else if (OBJECT_TYPE_TRANSLATION.equalsIgnoreCase(type))
{
// got the protein - get its Parent, restricted to type Transcript
String transcriptId = val.get(PARENT).toString();
geneId = getGeneId(transcriptId, OBJECT_TYPE_TRANSCRIPT);
}
} catch (ParseException e)
{
// ignore
}
return geneId;
}
}