/*
* Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
* Copyright (C) $$Year-Rel$$ The Jalview Authors
*
* This file is part of Jalview.
*
* Jalview is free software: you can redistribute it and/or
* modify it under the terms of the GNU General Public License
* as published by the Free Software Foundation, either version 3
* of the License, or (at your option) any later version.
*
* Jalview is distributed in the hope that it will be useful, but
* WITHOUT ANY WARRANTY; without even the implied warranty
* of MERCHANTABILITY or FITNESS FOR A PARTICULAR
* PURPOSE. See the GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with Jalview. If not, see .
* The Jalview Authors are detailed in the 'AUTHORS' file.
*/
package jalview.ext.ensembl;
import jalview.io.DataSourceType;
import jalview.io.FileParse;
import jalview.util.StringUtils;
import java.io.BufferedReader;
import java.io.DataOutputStream;
import java.io.IOException;
import java.io.InputStream;
import java.io.InputStreamReader;
import java.net.HttpURLConnection;
import java.net.MalformedURLException;
import java.net.URL;
import java.util.HashMap;
import java.util.List;
import java.util.Map;
import javax.ws.rs.HttpMethod;
import org.json.simple.JSONArray;
import org.json.simple.JSONObject;
import org.json.simple.parser.JSONParser;
import com.stevesoft.pat.Regex;
/**
* Base class for Ensembl REST service clients
*
* @author gmcarstairs
*/
abstract class EnsemblRestClient extends EnsemblSequenceFetcher
{
private static final int DEFAULT_READ_TIMEOUT = 5 * 60 * 1000; // 5 minutes
private static final int CONNECT_TIMEOUT_MS = 10 * 1000; // 10 seconds
/*
* update these constants when Jalview has been checked / updated for
* changes to Ensembl REST API (ref JAL-2105)
* @see https://github.com/Ensembl/ensembl-rest/wiki/Change-log
* @see http://rest.ensembl.org/info/rest?content-type=application/json
*/
private static final String LATEST_ENSEMBLGENOMES_REST_VERSION = "5.0";
private static final String LATEST_ENSEMBL_REST_VERSION = "5.0";
private static final String REST_CHANGE_LOG = "https://github.com/Ensembl/ensembl-rest/wiki/Change-log";
private static Map domainData;
// @see https://github.com/Ensembl/ensembl-rest/wiki/Output-formats
private static final String PING_URL = "http://rest.ensembl.org/info/ping.json";
private final static long AVAILABILITY_RETEST_INTERVAL = 10000L; // 10 seconds
private final static long VERSION_RETEST_INTERVAL = 1000L * 3600; // 1 hr
private static final Regex TRANSCRIPT_REGEX = new Regex(
"(ENS)([A-Z]{3}|)T[0-9]{11}$");
private static final Regex GENE_REGEX = new Regex(
"(ENS)([A-Z]{3}|)G[0-9]{11}$");
static
{
domainData = new HashMap();
domainData.put(ENSEMBL_REST, new EnsemblInfo(ENSEMBL_REST,
LATEST_ENSEMBL_REST_VERSION));
domainData.put(ENSEMBL_GENOMES_REST, new EnsemblInfo(
ENSEMBL_GENOMES_REST, LATEST_ENSEMBLGENOMES_REST_VERSION));
}
protected volatile boolean inProgress = false;
/**
* Default constructor to use rest.ensembl.org
*/
public EnsemblRestClient()
{
this(ENSEMBL_REST);
}
/**
* Constructor given the target domain to fetch data from
*
* @param d
*/
public EnsemblRestClient(String d)
{
setDomain(d);
}
/**
* Answers true if the query matches the regular expression pattern for an
* Ensembl transcript stable identifier
*
* @param query
* @return
*/
public boolean isTranscriptIdentifier(String query)
{
return query == null ? false : TRANSCRIPT_REGEX.search(query);
}
/**
* Answers true if the query matches the regular expression pattern for an
* Ensembl gene stable identifier
*
* @param query
* @return
*/
public boolean isGeneIdentifier(String query)
{
return query == null ? false : GENE_REGEX.search(query);
}
@Override
public boolean queryInProgress()
{
return inProgress;
}
@Override
public StringBuffer getRawRecords()
{
return null;
}
/**
* Returns the URL for the client http request
*
* @param ids
* @return
* @throws MalformedURLException
*/
protected abstract URL getUrl(List ids)
throws MalformedURLException;
/**
* Returns true if client uses GET method, false if it uses POST
*
* @return
*/
protected abstract boolean useGetRequest();
/**
* Return the desired value for the Content-Type request header
*
* @param multipleIds
*
* @return
* @see https://github.com/Ensembl/ensembl-rest/wiki/HTTP-Headers
*/
protected abstract String getRequestMimeType(boolean multipleIds);
/**
* Return the desired value for the Accept request header
*
* @return
* @see https://github.com/Ensembl/ensembl-rest/wiki/HTTP-Headers
*/
protected abstract String getResponseMimeType();
/**
* Checks Ensembl's REST 'ping' endpoint, and returns true if response
* indicates available, else false
*
* @see http://rest.ensembl.org/documentation/info/ping
* @return
*/
private boolean checkEnsembl()
{
BufferedReader br = null;
try
{
// note this format works for both ensembl and ensemblgenomes
// info/ping.json works for ensembl only (March 2016)
URL ping = new URL(getDomain()
+ "/info/ping?content-type=application/json");
/*
* expect {"ping":1} if ok
* if ping takes more than 2 seconds to respond, treat as if unavailable
*/
br = getHttpResponse(ping, null, 2 * 1000);
JSONParser jp = new JSONParser();
JSONObject val = (JSONObject) jp.parse(br);
String pingString = val.get("ping").toString();
return pingString != null;
} catch (Throwable t)
{
System.err.println("Error connecting to " + PING_URL + ": "
+ t.getMessage());
} finally
{
if (br != null)
{
try
{
br.close();
} catch (IOException e)
{
// ignore
}
}
}
return false;
}
/**
* returns a reader to a Fasta response from the Ensembl sequence endpoint
*
* @param ids
* @return
* @throws IOException
*/
protected FileParse getSequenceReader(List ids)
throws IOException
{
URL url = getUrl(ids);
BufferedReader reader = getHttpResponse(url, ids);
if (reader == null)
{
// request failed
return null;
}
FileParse fp = new FileParse(reader, url.toString(), DataSourceType.URL);
return fp;
}
/**
* Gets a reader to the HTTP response, using the default read timeout of 5
* minutes
*
* @param url
* @param ids
* @return
* @throws IOException
*/
protected BufferedReader getHttpResponse(URL url, List ids)
throws IOException
{
return getHttpResponse(url, ids, DEFAULT_READ_TIMEOUT);
}
/**
* Writes the HTTP request and gets the response as a reader.
*
* @param url
* @param ids
* written as Json POST body if more than one
* @param readTimeout
* in milliseconds
* @return
* @throws IOException
* if response code was not 200, or other I/O error
*/
protected BufferedReader getHttpResponse(URL url, List ids,
int readTimeout) throws IOException
{
// long now = System.currentTimeMillis();
HttpURLConnection connection = (HttpURLConnection) url.openConnection();
/*
* POST method allows multiple queries in one request; it is supported for
* sequence queries, but not for overlap
*/
boolean multipleIds = ids != null && ids.size() > 1;
connection.setRequestMethod(multipleIds ? HttpMethod.POST
: HttpMethod.GET);
connection.setRequestProperty("Content-Type",
getRequestMimeType(multipleIds));
connection.setRequestProperty("Accept", getResponseMimeType());
connection.setUseCaches(false);
connection.setDoInput(true);
connection.setDoOutput(multipleIds);
connection.setConnectTimeout(CONNECT_TIMEOUT_MS);
connection.setReadTimeout(readTimeout);
if (multipleIds)
{
writePostBody(connection, ids);
}
int responseCode = connection.getResponseCode();
if (responseCode != 200)
{
/*
* note: a GET request for an invalid id returns an error code e.g. 415
* but POST request returns 200 and an empty Fasta response
*/
System.err.println("Response code " + responseCode + " for " + url);
return null;
}
// get content
InputStream response = connection.getInputStream();
// System.out.println(getClass().getName() + " took "
// + (System.currentTimeMillis() - now) + "ms to fetch");
checkRateLimits(connection);
BufferedReader reader = null;
reader = new BufferedReader(new InputStreamReader(response, "UTF-8"));
return reader;
}
/**
* Inspect response headers for any sign of server overload and respect any
* 'retry-after' directive
*
* @see https://github.com/Ensembl/ensembl-rest/wiki/Rate-Limits
* @param connection
*/
void checkRateLimits(HttpURLConnection connection)
{
// number of requests allowed per time interval:
String limit = connection.getHeaderField("X-RateLimit-Limit");
// length of quota time interval in seconds:
// String period = connection.getHeaderField("X-RateLimit-Period");
// seconds remaining until usage quota is reset:
String reset = connection.getHeaderField("X-RateLimit-Reset");
// number of requests remaining from quota for current period:
String remaining = connection.getHeaderField("X-RateLimit-Remaining");
// number of seconds to wait before retrying (if remaining == 0)
String retryDelay = connection.getHeaderField("Retry-After");
// to test:
// retryDelay = "5";
EnsemblInfo info = domainData.get(getDomain());
if (retryDelay != null)
{
System.err.println("Ensembl REST service rate limit exceeded, wait "
+ retryDelay + " seconds before retrying");
try
{
info.retryAfter = System.currentTimeMillis()
+ (1000 * Integer.valueOf(retryDelay));
} catch (NumberFormatException e)
{
System.err.println("Unexpected value for Retry-After: "
+ retryDelay);
}
}
else
{
info.retryAfter = 0;
// debug:
// System.out.println(String.format(
// "%s Ensembl requests remaining of %s (reset in %ss)",
// remaining, limit, reset));
}
}
/**
* Rechecks if Ensembl is responding, unless the last check was successful and
* the retest interval has not yet elapsed. Returns true if Ensembl is up,
* else false. Also retrieves and saves the current version of Ensembl data
* and REST services at intervals.
*
* @return
*/
protected boolean isEnsemblAvailable()
{
EnsemblInfo info = domainData.get(getDomain());
long now = System.currentTimeMillis();
/*
* check if we are waiting for 'Retry-After' to expire
*/
if (info.retryAfter > now)
{
System.err.println("Still " + (1 + (info.retryAfter - now) / 1000)
+ " secs to wait before retrying Ensembl");
return false;
}
else
{
info.retryAfter = 0;
}
/*
* recheck if Ensembl is up if it was down, or the recheck period has elapsed
*/
boolean retestAvailability = (now - info.lastAvailableCheckTime) > AVAILABILITY_RETEST_INTERVAL;
if (!info.restAvailable || retestAvailability)
{
info.restAvailable = checkEnsembl();
info.lastAvailableCheckTime = now;
}
/*
* refetch Ensembl versions if the recheck period has elapsed
*/
boolean refetchVersion = (now - info.lastVersionCheckTime) > VERSION_RETEST_INTERVAL;
if (refetchVersion)
{
checkEnsemblRestVersion();
checkEnsemblDataVersion();
info.lastVersionCheckTime = now;
}
return info.restAvailable;
}
/**
* Constructs, writes and flushes the POST body of the request, containing the
* query ids in JSON format
*
* @param connection
* @param ids
* @throws IOException
*/
protected void writePostBody(HttpURLConnection connection,
List ids) throws IOException
{
boolean first;
StringBuilder postBody = new StringBuilder(64);
postBody.append("{\"ids\":[");
first = true;
for (String id : ids)
{
if (!first)
{
postBody.append(",");
}
first = false;
postBody.append("\"");
postBody.append(id.trim());
postBody.append("\"");
}
postBody.append("]}");
byte[] thepostbody = postBody.toString().getBytes();
connection.setRequestProperty("Content-Length",
Integer.toString(thepostbody.length));
DataOutputStream wr = new DataOutputStream(connection.getOutputStream());
wr.write(thepostbody);
wr.flush();
wr.close();
}
/**
* Fetches and checks Ensembl's REST version number
*
* @return
*/
private void checkEnsemblRestVersion()
{
EnsemblInfo info = domainData.get(getDomain());
JSONParser jp = new JSONParser();
URL url = null;
try
{
url = new URL(getDomain()
+ "/info/rest?content-type=application/json");
BufferedReader br = getHttpResponse(url, null);
JSONObject val = (JSONObject) jp.parse(br);
String version = val.get("release").toString();
String majorVersion = version.substring(0, version.indexOf("."));
String expected = info.expectedRestVersion;
String expectedMajorVersion = expected.substring(0,
expected.indexOf("."));
info.restMajorVersionMismatch = false;
try
{
/*
* if actual REST major version is ahead of what we expect,
* record this in case we want to warn the user
*/
if (Float.valueOf(majorVersion) > Float
.valueOf(expectedMajorVersion))
{
info.restMajorVersionMismatch = true;
}
} catch (NumberFormatException e)
{
System.err.println("Error in REST version: " + e.toString());
}
/*
* check if REST version is later than what Jalview has tested against,
* if so warn; we don't worry if it is earlier (this indicates Jalview has
* been tested in advance against the next pending REST version)
*/
boolean laterVersion = StringUtils.compareVersions(version, expected) == 1;
if (laterVersion)
{
System.err
.println(String
.format("EnsemblRestClient expected %s REST version %s but found %s, see %s",
getDbSource(), expected, version,
REST_CHANGE_LOG));
}
info.restVersion = version;
} catch (Throwable t)
{
System.err.println("Error checking Ensembl REST version: "
+ t.getMessage());
}
}
public boolean isRestMajorVersionMismatch()
{
return domainData.get(getDomain()).restMajorVersionMismatch;
}
/**
* Fetches and checks Ensembl's data version number
*
* @return
*/
private void checkEnsemblDataVersion()
{
JSONParser jp = new JSONParser();
URL url = null;
try
{
url = new URL(getDomain()
+ "/info/data?content-type=application/json");
BufferedReader br = getHttpResponse(url, null);
JSONObject val = (JSONObject) jp.parse(br);
JSONArray versions = (JSONArray) val.get("releases");
domainData.get(getDomain()).dataVersion = versions.get(0).toString();
} catch (Throwable t)
{
System.err.println("Error checking Ensembl data version: "
+ t.getMessage());
}
}
public String getEnsemblDataVersion()
{
return domainData.get(getDomain()).dataVersion;
}
@Override
public String getDbVersion()
{
return getEnsemblDataVersion();
}
}