/*
* Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
* Copyright (C) $$Year-Rel$$ The Jalview Authors
*
* This file is part of Jalview.
*
* Jalview is free software: you can redistribute it and/or
* modify it under the terms of the GNU General Public License
* as published by the Free Software Foundation, either version 3
* of the License, or (at your option) any later version.
*
* Jalview is distributed in the hope that it will be useful, but
* WITHOUT ANY WARRANTY; without even the implied warranty
* of MERCHANTABILITY or FITNESS FOR A PARTICULAR
* PURPOSE. See the GNU General Public License for more details.
*
* You should have received a copy of the GNU General Public License
* along with Jalview. If not, see .
* The Jalview Authors are detailed in the 'AUTHORS' file.
*/
package jalview.schemes;
import jalview.datamodel.AnnotatedCollectionI;
import jalview.datamodel.SequenceCollectionI;
import jalview.datamodel.SequenceI;
import jalview.util.Comparison;
import java.awt.Color;
import java.util.List;
import java.util.Map;
public class ClustalxColourScheme extends ResidueColourScheme
{
private static final int EIGHTY_FIVE = 85;
private static final int FIFTY = 50;
private static final int EIGHTY = 80;
private static final int SIXTY = 60;
enum ClustalColour
{
RED(0.9f, 0.2f, 0.1f), BLUE(0.5f, 0.7f, 0.9f), GREEN(0.1f, 0.8f, 0.1f),
ORANGE(0.9f, 0.6f, 0.3f), CYAN(0.1f, 0.7f, 0.7f),
PINK(0.9f, 0.5f, 0.5f), MAGENTA(0.8f, 0.3f, 0.8f),
YELLOW(0.8f, 0.8f, 0.0f);
final Color colour;
ClustalColour(float r, float g, float b)
{
colour = new Color(r, g, b);
}
}
private class ConsensusColour
{
Consensus[] cons;
Color c;
public ConsensusColour(ClustalColour col, Consensus[] conses)
{
this.cons = conses;
this.c = col.colour;
}
}
private int[][] cons2;
private ConsensusColour[] colours;
private ConsensusColour[] residueColour;
private int size;
private Consensus[] conses = new Consensus[32];
private boolean includeGaps = true;
/**
* Default constructor (required for Class.newInstance())
*/
public ClustalxColourScheme()
{
}
public ClustalxColourScheme(AnnotatedCollectionI alignment,
Map hiddenReps)
{
alignmentChanged(alignment, hiddenReps);
}
@Override
public void alignmentChanged(AnnotatedCollectionI alignment,
Map hiddenReps)
{
int maxWidth = alignment.getWidth();
List seqs = alignment.getSequences(hiddenReps);
cons2 = new int[maxWidth][24];
includeGaps = isIncludeGaps(); // does nothing - TODO replace with call to
// get the current setting of the
// includeGaps param.
int res = 0;
for (SequenceI sq : seqs)
{
int end_j = sq.getLength() - 1;
int length = sq.getLength();
for (int i = 0; i <= end_j; i++)
{
if (length - 1 < i)
{
res = 23;
}
else
{
res = ResidueProperties.aaIndex[sq.getCharAt(i)];
}
cons2[i][res]++;
}
}
this.size = seqs.size();
makeColours();
}
void makeColours()
{
conses[0] = new Consensus("WLVIMAFCYHP", SIXTY);
conses[1] = new Consensus("WLVIMAFCYHP", EIGHTY);
conses[2] = new Consensus("ED", FIFTY);
conses[3] = new Consensus("KR", SIXTY);
conses[4] = new Consensus("G", FIFTY);
conses[5] = new Consensus("N", FIFTY);
conses[6] = new Consensus("QE", FIFTY);
conses[7] = new Consensus("P", FIFTY);
conses[8] = new Consensus("TS", FIFTY);
conses[26] = new Consensus("A", EIGHTY_FIVE);
conses[27] = new Consensus("C", EIGHTY_FIVE);
conses[10] = new Consensus("E", EIGHTY_FIVE);
conses[11] = new Consensus("F", EIGHTY_FIVE);
conses[12] = new Consensus("G", EIGHTY_FIVE);
conses[13] = new Consensus("H", EIGHTY_FIVE);
conses[14] = new Consensus("I", EIGHTY_FIVE);
conses[15] = new Consensus("L", EIGHTY_FIVE);
conses[16] = new Consensus("M", EIGHTY_FIVE);
conses[17] = new Consensus("N", EIGHTY_FIVE);
conses[18] = new Consensus("P", EIGHTY_FIVE);
conses[19] = new Consensus("Q", EIGHTY_FIVE);
conses[20] = new Consensus("R", EIGHTY_FIVE);
conses[21] = new Consensus("S", EIGHTY_FIVE);
conses[22] = new Consensus("T", EIGHTY_FIVE);
conses[23] = new Consensus("V", EIGHTY_FIVE);
conses[24] = new Consensus("W", EIGHTY_FIVE);
conses[25] = new Consensus("Y", EIGHTY_FIVE);
conses[28] = new Consensus("K", EIGHTY_FIVE);
conses[29] = new Consensus("D", EIGHTY_FIVE);
conses[30] = new Consensus("G", 0);
conses[31] = new Consensus("P", 0);
// We now construct the colours
colours = new ConsensusColour[11];
Consensus[] tmp8 = new Consensus[1];
tmp8[0] = conses[30]; // G
colours[7] = new ConsensusColour(ClustalColour.ORANGE, tmp8);
Consensus[] tmp9 = new Consensus[1];
tmp9[0] = conses[31]; // P
colours[8] = new ConsensusColour(ClustalColour.YELLOW, tmp9);
Consensus[] tmp10 = new Consensus[1];
tmp10[0] = conses[27]; // C
colours[9] = new ConsensusColour(ClustalColour.PINK, tmp8);
Consensus[] tmp1 = new Consensus[14];
tmp1[0] = conses[0]; // %
tmp1[1] = conses[1]; // #
tmp1[2] = conses[26]; // A
tmp1[3] = conses[27]; // C
tmp1[4] = conses[11]; // F
tmp1[5] = conses[13]; // H
tmp1[6] = conses[14]; // I
tmp1[7] = conses[15]; // L
tmp1[8] = conses[16]; // M
tmp1[9] = conses[23]; // V
tmp1[10] = conses[24]; // W
tmp1[11] = conses[25]; // Y
tmp1[12] = conses[18]; // P
tmp1[13] = conses[19]; // p
colours[0] = new ConsensusColour(ClustalColour.BLUE, tmp1);
colours[10] = new ConsensusColour(ClustalColour.CYAN, tmp1);
Consensus[] tmp2 = new Consensus[5];
tmp2[0] = conses[8]; // t
tmp2[1] = conses[21]; // S
tmp2[2] = conses[22]; // T
tmp2[3] = conses[0]; // %
tmp2[4] = conses[1]; // #
colours[1] = new ConsensusColour(ClustalColour.GREEN, tmp2);
Consensus[] tmp3 = new Consensus[3];
tmp3[0] = conses[17]; // N
tmp3[1] = conses[29]; // D
tmp3[2] = conses[5]; // n
colours[2] = new ConsensusColour(ClustalColour.GREEN, tmp3);
Consensus[] tmp4 = new Consensus[6];
tmp4[0] = conses[6]; // q = QE
tmp4[1] = conses[19]; // Q
tmp4[2] = conses[22]; // E
tmp4[3] = conses[3]; // +
tmp4[4] = conses[28]; // K
tmp4[5] = conses[20]; // R
colours[3] = new ConsensusColour(ClustalColour.GREEN, tmp4);
Consensus[] tmp5 = new Consensus[4];
tmp5[0] = conses[3]; // +
tmp5[1] = conses[28]; // K
tmp5[2] = conses[20]; // R
tmp5[3] = conses[19]; // Q
colours[4] = new ConsensusColour(ClustalColour.RED, tmp5);
Consensus[] tmp6 = new Consensus[6];
tmp6[0] = conses[3]; // -
tmp6[1] = conses[29]; // D
tmp6[2] = conses[10]; // E
tmp6[3] = conses[6]; // QE
tmp6[4] = conses[19]; // Q
tmp6[5] = conses[2]; // DE
colours[5] = new ConsensusColour(ClustalColour.MAGENTA, tmp6);
Consensus[] tmp7 = new Consensus[5];
tmp7[0] = conses[3]; // -
tmp7[1] = conses[29]; // D
tmp7[2] = conses[10]; // E
tmp7[3] = conses[17]; // N
tmp7[4] = conses[2]; // DE
colours[6] = new ConsensusColour(ClustalColour.MAGENTA, tmp7);
// Now attach the ConsensusColours to the residue letters
residueColour = new ConsensusColour[20];
residueColour[0] = colours[0]; // A
residueColour[1] = colours[4]; // R
residueColour[2] = colours[2]; // N
residueColour[3] = colours[6]; // D
residueColour[4] = colours[0]; // C
residueColour[5] = colours[3]; // Q
residueColour[6] = colours[5]; // E
residueColour[7] = colours[7]; // G
residueColour[8] = colours[10]; // H
residueColour[9] = colours[0]; // I
residueColour[10] = colours[0]; // L
residueColour[11] = colours[4]; // K
residueColour[12] = colours[0]; // M
residueColour[13] = colours[0]; // F
residueColour[14] = colours[8]; // P
residueColour[15] = colours[1]; // S
residueColour[16] = colours[1]; // T
residueColour[17] = colours[0]; // W
residueColour[18] = colours[10]; // Y
residueColour[19] = colours[0]; // V
}
@Override
public Color findColour(char c)
{
return Color.pink;
}
@Override
protected Color findColour(char c, int j, SequenceI seq)
{
// TODO why the test for includeGaps here?
if (cons2.length <= j || Comparison.isGap(c)
/*|| (includeGaps && threshold != 0 && !aboveThreshold(c, j))*/)
{
return Color.white;
}
int i = ResidueProperties.aaIndex[c];
Color colour = Color.white;
if (i > 19)
{
return colour;
}
for (int k = 0; k < residueColour[i].cons.length; k++)
{
if (residueColour[i].cons[k].isConserved(cons2, j, size, includeGaps))
{
colour = residueColour[i].c;
}
}
if (i == 4)
{
/*
* override to colour C pink if >85% conserved
*/
if (conses[27].isConserved(cons2, j, size, includeGaps))
{
colour = ClustalColour.PINK.colour;
}
}
return colour;
}
/**
* @return the includeGaps
*/
protected boolean isIncludeGaps()
{
return includeGaps;
}
/**
* @param includeGaps
* the includeGaps to set
*/
protected void setIncludeGaps(boolean includeGaps)
{
this.includeGaps = includeGaps;
}
@Override
public ColourSchemeI getInstance(AnnotatedCollectionI sg,
Map hiddenRepSequences)
{
ClustalxColourScheme css = new ClustalxColourScheme(sg,
hiddenRepSequences);
css.includeGaps = includeGaps;
return css;
}
@Override
public boolean isPeptideSpecific()
{
return true;
}
@Override
public String getSchemeName()
{
return JalviewColourScheme.Clustal.toString();
}
@Override
public boolean isSimple()
{
return false;
}
}