CLUSTAL W (1.81) multiple sequence alignment Sequence12 ----------------------------------------------VDSMVCFTQTKPGA Sequence0 ---------------------------------------------TWDG-GCWRDANPDN Sequence1 ---------------------------------------------TWDG-SCWTTQSPGA Sequence13 ---------------------------------------------YYDE-VCWVASPPGV Sequence16 SCRLLAAMATGSSDLHLELLVLVFLVTNVPAVTFLSLLLRSGCTGMWDKIACWPSADLGA Sequence17 MCDI-------ERELNKEKEACEAQMENKTA----------GCTGMWDKIACWPSADLGA Sequence7 ---------------------------------------------EWDG-ICWPRGTVGS Sequence5 ---------------------------------------------EWDG-ICWPRGSPGT Sequence6 ---------------------------------------------EWDG-ICWPQGFPGT Sequence9 ---------------------------------------------EWDG-FCWPYGTPGV Sequence8 ---------------------------------------------EWDK-TCWPNSAPGV Sequence10 ----------------------------------------------WDTVSCWPTTPAGA Sequence11 ----------------------------------------------QDEFSCWPATPEGA Sequence14 ------------------YLLTI----------------EIYCNWTWDSVLCWPPTKEDT Sequence15 -------------MSSGEYLNKTVEICVEKFKNFLPPNGEIYCNWTWDSVLCWPPTKEDT Sequence4 ---------------------------------------------TFDG-SCWNATPAGS Sequence2 ---------------------------------------------IFDE-LCWPETLGGV Sequence3 ---------------------------------------------NFDG-LCWPRTPAGL * *: . Sequence12 --YSGCPT---------------LNSSKECYMNGTW------------------------ Sequence0 --YLSCPN---------------LNALKYCHSNGTW------------------------ Sequence1 --IQGCPA---------------LNSAKSCTANGTW------------------------ Sequence13 --ERQCPE---------------FTVTRLCMFNGSW------------------------ Sequence16 EVTIPCPKYLFFFSGDALPPRSPGNLSKTCTADG-WTPVSIDYTGDCGYDPNDTVN---- Sequence17 EVTIPCPKYLFFFSGDA----QPRNLSKTCTADG-WTPVSIDYTGDCGYDPNDTVN---- Sequence7 --AVPCPP---------------IVAFRHCNPNGTW------------------------ Sequence5 --RVPCPS---------------IHAYRTCDINGSW------------------------ Sequence6 --KTPCPG---------------IHAYRRCDSNGSS------------------------ Sequence9 --GAECPP---------------FHAYRHCGLSGNW------------------------ Sequence8 --RLPCPE---------------ITVDRYCMSDGTW------------------------ Sequence10 --VLTCPP---------------FNATRMCYPNGTW------------------------ Sequence11 --TIPCPK---------------LNATRFCGEDGVW------------------------ Sequence14 VAVQNCPKDYNYFKTLT------ELVYKKCLPGGRWEGRIKGHDDSPQGWTNYTTCFTPE Sequence15 VAVQNCPKDRGIDPS--------KLVYKKCLPGGRWEGRIKGHDDSPQGWTNYTTCFTPE Sequence4 --VAPCPY---------------FMAHKICTEEGTW------------------------ Sequence2 --NQSCPK---------------KFAYKDCLENGSW------------------------ Sequence3 --SQYCPD---------------FLAHKTCLENGSW------------------------ ** . * * Sequence12 ------------------------------VLGRSISLFALCIAFASFCIL----RNLKM Sequence0 ------------------------------YLCNIASILLLLPAIAIFLVY----KQHRI Sequence1 ------------------------------NLLNVISIVFIIPAIVIFLAF----QQNRV Sequence13 ------------------------------ILGYSLSFTTLLGAFVILVYF----RCVRN Sequence16 --------HEVSRDEVHVQESFYNAVKVGYTVGHSVSLVSLTVGVIILCVF-RKIHCTRN Sequence17 --------HE-------VQESFYNAVKVGYTVGHSVSLVSLTVGVIILCVF-RKLHCTRN Sequence7 ------------------------------VMGYSISFGSLAVAILIIGYF----HCTRN Sequence5 ------------------------------VIGYAVSFSSLMVAILIMGFF----HCTRN Sequence6 ------------------------------IMGYAVSFSSLLVAIFIIGYF----HCTRN Sequence9 ------------------------------KIGYSISLVSLFIAFIILARF----HCTRN Sequence8 ------------------------------SLGYSFSLVALVFAMIILAYF----HCTRN Sequence10 ------------------------------VIGFTTSIVALIVALCIFLYF----RCLRN Sequence11 ------------------------------IIGFIITTIALVAALIIFLYF----RCLRN Sequence14 TWQLFKMLYADSEDTAKIKLDIAEKTRTLEIVGFSVSLIALLFSLAIFFRFRRGLRNSRT Sequence15 TWQLFKMLYADSEDTAKIKLDIAEKTRTLEIVGFSVSLIALLFSLAIFFRF-RGLRNSRT Sequence4 ------------------------------YIGYSVSLIALVMSLAILIAF----KCTRI Sequence2 ------------------------------FVGYSISLAALVISLAIFFTF----KCTRI Sequence3 ------------------------------YVGYALSLLALLISIIIFLGF----RCTRI : : : .. : . . Sequence12 IIHWNFVMSLIIRNVTWF--------------LL-------F------------------ Sequence0 RLHISFFLSFILSDVTAI--------------LW-------D------------------ Sequence1 KVHIHLLIALGLCSFVTM--------------LW-------Y------------------ Sequence13 YIHLNLVTSFLLLYLIFF--------------LM-------I------------------ Sequence16 YIHIHLFVAFILKAVTVF--------------IK-------DVVLFGVGETMKCRFRSER Sequence17 YIHIHLFVAFILKAVTVF--------------IK-------DVVLFGVGETMKCQ----- Sequence7 YIHMHLFVSFMLRATSIF--------------VK-------D------------------ Sequence5 YIHMHLFLSFMLRAVSIF--------------VK-------D------------------ Sequence6 YIHMHLFVSFMLRAASIF--------------VK-------D------------------ Sequence9 YVHMHLFVSYMLRAFFIL--------------LR-------D------------------ Sequence8 YIHMHLFASFILRAVVIF--------------VK-------D------------------ Sequence10 TIHCHLIVTFIFKYILWL--------------IM-------N------------------ Sequence11 VIHCHLIVTFILRHILWV--------------IM-------H------------------ Sequence14 RIHKNLFIAMEIQVVVRLSLYIDQVIVKE--FFFQ-----PF------------------ Sequence15 RIHKNLFIAMEIQVVVRLSLYIDQVIVKEKINFWQGIHDTPF------------------ Sequence4 YIHRNLFASFIINNAMWL--------------LW-------Y------------------ Sequence2 RIHIQLFISFALNNLMWI--------------IW-------Y------------------ Sequence3 RIHVHLFASLACTCVAWI--------------LW-------Y------------------ :* :. : . . Sequence12 ----------------------GCRVFAILFNYALIVTFSWMMVEGIMIHRKLES--FMS Sequence0 ----------------------VCKALSFFRIYCKSTNYVWMFCEGFYLHRLISN--FKP Sequence1 ----------------------ACQVLAVLKLYLSSSTYWWMLCEGIYLHRLLVN--FHP Sequence13 ----------------------ICRLQATALFYINLTSFFWMFVEGLYLHTMVVR--LAV Sequence16 QRFYGLTVVFMLNASIRLVFQVGCKAVMVFFHYGIMASFFWLLVEGLYLHTLLAVS-FFS Sequence17 -------------------ATVGCKAVMVFFHYGIMASFFWLLVEGLYLHTLLAVS-FFS Sequence7 ----------------------RCKIAVVMFIYFLATNYYWILVEGLYLHNLIFV--FFS Sequence5 ----------------------RCKVTVVLFIYFLATNYFWILVEGLYLHSLIFM--FRT Sequence6 ----------------------HCKVTVLLFIYFLATNYYWILVEGLYLHSLIFM--FLS Sequence9 ----------------------ACKLLYTCFMYFMATNYFWILVEGLYLHNLIFV--VFS Sequence8 ----------------------RCKLVMTLFHYFVATNYYWILVEALYLHSLIFV--FFS Sequence10 ----------------------NCKIIVALYNYIQVANFFWMLVEGLYLHTMIVW--FSI Sequence11 ----------------------NCKLIVTVYNYLHGTNFFWMFVEGLYLFTIIVW--YSA Sequence14 ----------------------LCEISYILLEYARTAMFMWMFVEGLYLHNMISVTVFHK Sequence15 ----------------------LCEISYILLEYARTAMFMWMFVEGLYLHNMITVTVFHK Sequence4 ----------------------KCKILHVLLHYFLVSNYFWMFCEGLYLHTVLVV--FLS Sequence2 ----------------------KCQALHLVVHYLMLANYMWMFCEGLHLHLALVV--FVR Sequence3 ----------------------RCIGLHLVVHYFMLVNYFWMFCEGLHLHLVLVV--FVK * * : *:: *.: :. : Sequence12 MASRCV---LLGW---IPIMMFWAILKE----NKDNH--------DYIYLVPIGIVLLIN Sequence0 PKLPLY---LTGW---MIYSVIYAALRA----NESCW--------EWIIYAPNLLCLVVN Sequence1 PKLMFC---VLGW---AVCIVIYAAIRS----NTHCW--------EWIVYAPNLLCLIVN Sequence13 RRKVYC---LIGW---VIFSVAYAITVA----TGTCL--------EYIIRVPIIAVILVN Sequence16 ERKYFWGYILIGWGAPPVFIAAWVITKA-CLNDDRCWDIIDDTL-WWIIKTPILVTILVN Sequence17 ERKYFWGYILIGWGAPPVFIAAWVITKA-CLNDPGCWDIIDDTL-WWIIKTPILVTILVN Sequence7 DTYGFI---LIGW---AAFVAAWAVARA----DARCW--------KWIYQAPILAAIGLN Sequence5 ANYGFI---LMGW---AVFVAVWAIVRA----DARCW--------KWIYQVPILMAIALN Sequence6 DSYGFT---LIGW---AVFVAAWAVVRA----DARCW--------KWIYQVPILTAIGLN Sequence9 ERFGFI---AIGW---LTFVVPWVVVRE----DTGCW--------KWIYKAPIVVSIVVN Sequence8 DKYRFS---VTGW---ILFVVPWAIVRD----DTACW--------KWIYNGPIVVANVIN Sequence10 ERRYYA---VLGW---ALVVLAWAIVKE----NRRPM--------DYIYITPILGVLLVN Sequence11 DKRYYV---IIGWG--LLFLLVDVMLSF----SPV----------DYILHAPIFFVLVSN Sequence14 EQSYYTMYSIIGWGSPIIITSAWILVMITYYKTSKCWWGYNLTIYFWILEGPRLTVVVVN Sequence15 EQSYYTMYSIIGWGSPIIITSAWILVMITYYKTSKCWWGYNLTIYFWILEGPRLTVVVLN Sequence4 ENSWFH---LIGW---AVVTSIYAGVRI----PEECW--------TWILSGPVCLSMLTN Sequence2 DAEWFF---ALGW---FIIVLIYSVVRI----LKDCW--------SWILTAPVCISLLVS Sequence3 DTIWFI---VISW---IPIAIVYGLARS----SPDCW--------LWIFSVPITLSLLAS .* :* * . Sequence12 GFIFCNFVCIL----------------AKCVSKAFVFYFSLLGLTYLI------------ Sequence0 LFFLCNILRVL----------------VTQALKATFVLIPLFGIQLFV------------ Sequence1 MATLVNILRIL----------------LFKGVKAAFMLIPLFGLQMLL------------ Sequence13 VCFMVHIMIIL----------------VTKGVRGIVVLLPLLGASYFM------------ Sequence16 FFLFIRIIRILRQKMNCPDIGRKESH-LRRLAKSTLLLIPLFGINYII------------ Sequence17 FFLFIRIIRILRQKMNCPDIGRKESHQCSRLAKSTLLLIPLFGINYII------------ Sequence7 FILFLNTVRVL----------------ATKLAKSTLVLVLVFGVHYIV------------ Sequence5 FILFVNIVRVL----------------ATKLAKSTLVLVLVFGIHYII------------ Sequence6 FILFVNIVRVL----------------ATKLAKSTQVLVFVFGVHYIV------------ Sequence9 FLLFLNILRVL----------------VKKLAKSTMVLIPLFGVHYIV------------ Sequence8 FLLFLNIIRVL----------------WYKLAKSTLVLIPMFGVHAIV------------ Sequence10 VIFLGSIVWVL----------------ITKAVRATLILFPLLGVTYVV------------ Sequence11 IFFLSAIIWVL----------------ITKAVKATIILFPLLGVTYVL------------ Sequence14 FLFLLNIIRVLVVKLRQSKQTEIKRSSFRKAVRATAVLLPLLGITNIISMSKSPLEKSVW Sequence15 FLFLLNIIRVLVVKLRQSRKSEIEQ--VRKAVRATAVLLPLLGITNIISMSKSPLEKSVW Sequence4 AFFLVNIVRVL----------------VTKNCKATLILLPLLGLHYVV------------ Sequence2 LIFLINVLRVI----------------LTIAARAALILIPLFGLQHIL------------ Sequence3 FIFLINVLRVI----------------VRKAVRATIILVPLFGLQHFL------------ : : :: .. . . ::* .: Sequence12 --FMF----------IYTNVILESFQGFFICLFHCFCNTHMR------------------ Sequence0 --TLY----------EKFTTFVINSQGFFVALIFCFCNGEVR------------------ Sequence1 --TIY----------EYFTFIVTNSQGIFVAVIFCYLNGEVI------------------ Sequence13 --LLY----------RYLNAFLQSTQGFFVAIIYVYMNQEVQ------------------ Sequence16 --FAFLPDHIQTKGRLVFDLILGSFQSFVVVVLYCFLNGEVQAEIKRKWRRWTLQRFLGA Sequence17 --FAFLPDHIQTKGRLVFDLILGSFQGFVVVVLYCFLNGEVQAEIKRKWRRWTLQRFLGA Sequence7 --FVR----------MHCELFFNSFQGFFVSIIYCYCNGEVQ------------------ Sequence5 --FVR----------MYCELFFNSFQGFFVSIIYCYCNGEVQ------------------ Sequence6 --FVR----------MYCELFFNSFQGFFVSIIYCYCNGEVQ------------------ Sequence9 --FVR----------LYFELFFNSFQGFFVSILYCFLNGEVR------------------ Sequence8 --FIR----------MSFDLFFNSFQGFFVAIIYCFCNGEVQ------------------ Sequence10 --FIF----------VYFNAILQSLQGLAIAVFYCFLNGEVR------------------ Sequence11 --FLF----------KYANALLQSFQGLFVAVFYCFLNGEVR------------------ Sequence14 EFALW----------SYGTHFLTSFQGFFIAFLYCFLNGEVRQVLRKRKRKRRRRK---- Sequence15 EFALW----------SYGTHFLTSFQGFFIAFLYCFLNGEVRAVVMKSVSTYFSLRNNQQ Sequence4 --MPY----------QIVSAIFTSFQGLCVAFLFCFCNGEVL------------------ Sequence2 --IPY----------QYVTVVVVTLQGLCVSCLFCFANQDVH------------------ Sequence3 --LPY----------QMLSVVLVSLQGFVVSFLFCFANHDVT------------------ .. . *.: : :. : * : Sequence12 ------------------------------------------- Sequence0 ------------------------------------------- Sequence1 ------------------------------------------- Sequence13 ------------------------------------------- Sequence16 ------------------------------------------- Sequence17 DTRYQQPSIGSNGNNFSTQITVTIRSSPATRRASECREHLPAI Sequence7 ------------------------------------------- Sequence5 ------------------------------------------- Sequence6 ------------------------------------------- Sequence9 ------------------------------------------- Sequence8 ------------------------------------------- Sequence10 ------------------------------------------- Sequence11 ------------------------------------------- Sequence14 ------------------------------------------- Sequence15 HKQFQHHKQSTSKTTTNDKTNGKQIENQNDDVNDAQWKRTRV- Sequence4 ------------------------------------------- Sequence2 ------------------------------------------- Sequence3 -------------------------------------------