import jalview.datamodel.features.SequenceFeaturesI;
+import java.util.BitSet;
import java.util.List;
import java.util.Vector;
public String getSequenceAsString(int start, int end);
/**
- * Get the sequence as a character array
+ * Answers a copy of the sequence as a character array
*
- * @return seqeunce and any gaps
+ * @return
*/
public char[] getSequence();
public int findIndex(int pos);
/**
- * Returns the sequence position for an alignment position
+ * Returns the sequence position for an alignment position.
*
* @param i
* column index in alignment (from 0..<length)
*
- * @return residue number for residue (left of and) nearest ith column
+ * @return TODO: JAL-2562 - residue number for residue (left of and) nearest
+ * ith column
*/
public int findPosition(int i);
/**
- * Returns the range of sequence positions included in the given alignment
- * position range. If no positions are included (the range is entirely gaps),
- * then returns null.
- *
- * <pre>
- * Example:
- * >Seq/8-13
- * ABC--DE-F
- * findPositions(1, 4) returns Range(9, 9) // B only
- * findPositions(3, 4) returns null // all gaps
- * findPositions(2, 6) returns Range(10, 12) // CDE
- * findPositions(3, 7) returns Range(11,12) // DE
- * </pre>
- *
- * @param fromCol
- * first aligned column position (base 0, inclusive)
- * @param toCol
- * last aligned column position (base 0, inclusive)
+ * Returns the from-to sequence positions (start..) for the given column
+ * positions (1..), or null if no residues are included in the range
*
+ * @param fromColum
+ * @param toColumn
* @return
*/
- public Range findPositions(int fromCol, int toCol);
+ public Range findPositions(int fromColum, int toColumn);
/**
* Returns an int array where indices correspond to each residue in the
* Answers a list of all sequence features associated with this sequence. The
* list may be held by the sequence's dataset sequence if that is defined.
*
- * @return hard reference to array
+ * @return
*/
public List<SequenceFeature> getSequenceFeatures();
public List<DBRefEntry> getPrimaryDBRefs();
/**
- * Returns a (possibly empty) list of sequence features that overlap the range
- * from-to (inclusive), optionally restricted to one or more specified feature
- * types
+ * Returns a (possibly empty) list of sequence features that overlap the given
+ * alignment column range, optionally restricted to one or more specified
+ * feature types. If the range is all gaps, then features which enclose it are
+ * included (but not contact features).
*
- * @param from
- * @param to
+ * @param fromCol
+ * start column of range inclusive (1..)
+ * @param toCol
+ * end column of range inclusive (1..)
* @param types
+ * optional feature types to restrict results to
* @return
*/
- List<SequenceFeature> findFeatures(int from, int to, String... types);
+ List<SequenceFeature> findFeatures(int fromCol, int toCol, String... types);
+
+ /**
+ * Method to call to indicate that the sequence (characters or alignment/gaps)
+ * has been modified. Provided to allow any cursors on residue/column
+ * positions to be invalidated.
+ */
+ void sequenceChanged();
+
+ /**
+ *
+ * @return BitSet corresponding to index [0,length) where Comparison.isGap()
+ * returns true.
+ */
+ BitSet getInsertionsAsBits();
+
+ /**
+ * Replaces every occurrence of c1 in the sequence with c2 and returns the
+ * number of characters changed
+ *
+ * @param c1
+ * @param c2
+ */
+ public int replace(char c1, char c2);
}