|
|
- General
+ Calculations
+
+ -
+ Occupancy annotation row shows number of
+ ungapped positions in each column of the alignment.
+
+ -
+ Tree/PCA calculation menu items merged to
+ a calculation dialog box
+
-
Revised implementation of PCA for speed
and memory efficiency (~30x faster)
@@ -84,18 +93,20 @@ li:before {
Revised implementation of sequence
similarity scores as used by Tree, PCA, Shading Consensus
and other calculations
-
- -
- Score matrices are stored as resource
- files within the Jalview codebase
-
-
- Trees computed on Sequence Feature
- Similarity may have different topology due to
- increased precision
-
-
-
+ Score matrices are stored as resource
+ files within the Jalview codebase
+
+ -
+ Trees computed on Sequence Feature
+ Similarity may have different topology due to increased
+ precision
+
+
+ Rendering
+
+ -
More robust colours and shader
model for alignments and groups
@@ -103,38 +114,48 @@ li:before {
Custom shading schemes created via groovy
scripts
- -
- linked scrolling of CDS/Protein views
- via Overview or sequence motif search operations
-
+
+ Overview
+
-
Efficiency improvements for interacting
with alignment and overview windows
-
+ Scrolling of wrapped alignment views via
+ overview
+
+ -
Hidden columns and sequences can be
omitted in Overview
-
+ Click-drag in visible area allows fine
+ adjustment of visible position
+
+
+
+ Data import/export
+
+ -
Posterior probability annotation from
Stockholm files imported as sequence associated annotation
-
+ More robust per-sequence positional
+ annotation input/output via stockholm flatfile
+
+ -
Sequence names don't include file
extension when importing structure files without embedded
names or PDB accessions
-
- Amend sequence features dialog box can be
- opened by double clicking gaps within sequence feature
- extent
-
- -
- Graduated feature colour style example
- included in the example feature file
+ Drag and drop load of AAIndex and NCBI
+ format sequence substitution matrices
- Application
+ User Interface
-
Experimental Features Checkbox in
@@ -142,100 +163,158 @@ li:before {
the application.
-
- Warning in alignment status bar when
- there are not enough columns to superimpose structures in
- Chimera
+ Linked scrolling of CDS/Protein views
+ via Overview or sequence motif search operations
+
+ -
+ Amend sequence features dialog box can be
+ opened by double clicking gaps within sequence feature
+ extent
+
+ -
+ Status bar message shown when not enough
+ aligned positions were available to create a 3D structure
+ superposition.
+
+
+ 3D Structure
+
+ -
+ Hidden regions in alignment views are not
+ coloured in linked structure views
-
Faster Chimera/Jalview communication by
file-based command exchange
-
+ Structure chooser automatically shows
+ Cached Structures rather than querying the PDBe if
+ structures are already available for sequences
+
+ -
+ Structures imported via URL are cached in
+ the Jalview project rather than downloaded again when the
+ project is reopened.
+
+ -
+ New entries in the Chimera menu
+ to transfer Chimera's structure attributes as Jalview
+ features, and vice-versa (Experimental
+ Feature)
+
+
+ Web Services
+
+ -
+ Updated JABAWS client to v2.2
+
+ -
+ Filter non-standard amino acids and nucleotides when submitting to AACon and other MSA Analysis services
+
+ -
URLs for viewing database
cross-references provided by identifiers.org and the
EMBL-EBI's MIRIAM DB
+
+
+ Scripting
+
-
- Updated JABAWS client to v2.2
+ FileFormatI interface for describing and
+ identifying file formats (instead of String constants)
-
- Drag and drop load of AAIndex and NCBI
- format sequence substitution matrices
+ FeatureCounter script refactored for
+ efficiency when counting all displayed features (not
+ backwards compatible with 2.10.1)
- Experimental features
+ Example files
-
- New entries in the Chimera menu
- to transfer Chimera's structure attributes as Jalview
- features, and vice-versa.
+ Graduated feature colour style example
+ included in the example feature file
- Applet
+ Documentation
-
-
+ Release notes reformatted for readability
+ with the built-in Java help viewer
+
+ -
+ Find documentation updated with 'search
+ sequence description' option
Test Suite
-
+ External service integration tests for
+ Uniprot REST Free Text Search Client
+
+ -
Added PrivilegedAccessor to test suite
-
Prevent or clear modal dialogs raised
during tests
- -
- Scripting
-
- -
- FileFormatI interface for describing
- and identifying file formats (instead of String
- constants)
-
- -
-
-
-
-
-
|
- General
+ Calculations
-
Fixed incorrect value in BLOSUM 62 score
matrix - C->R should be '-3'
Old matrix restored
with this one-line groovy script:
jalview.analysis.scoremodels.ScoreModels.instance.BLOSUM62.@matrix[4][1]=3
- -
+
-
Fixed Jalview's treatment of gaps in PCA
- and substitution matrix based Tree calculations.
In
+ and substitution matrix based Tree calculations.
In
earlier versions of Jalview, gaps matching gaps were
penalised, and gaps matching non-gaps penalised even more.
In the PCA calculation, gaps were actually treated as
non-gaps - so different costs were applied, which meant
Jalview's PCAs were different to those produced by
SeqSpace.
Jalview now treats gaps in the same way as
- SeqSpace (ie it scores them as 0). To restore pre-2.10.2
- behaviour
- jalview.viewmodel.PCAModel.scoreGapAsAny=true // for
- 2.10.1 mode
- jalview.viewmodel.PCAModel.scoreGapAsAny=false // to
- restore 2.10.2 mode
+ SeqSpace (ie it scores them as 0).
Enter
+ the following in the Groovy console to restore pre-2.10.2
+ behaviour:
+ jalview.analysis.scoremodels.ScoreMatrix.scoreGapAsAny=true
+ // for 2.10.1 mode
+ jalview.analysis.scoremodels.ScoreMatrix.scoreGapAsAny=false
+ // to restore 2.10.2 mode
Note:
+ these settings will affect all subsequent tree and PCA
+ calculations (not recommended)
+
+ -
+ Fixed off-by-one bug that affected
+ scaling of branch lengths for trees computed using
+ Sequence Feature Similarity.
-
+ PCA calculation could hang when
+ generating output report when working with highly
+ redundant alignments
+
+ -
+ Sort by features includes features to
+ right of selected region when gaps present on right-hand
+ boundary
+
+
+ User Interface
+
+ -
Reopening Colour by annotation dialog
doesn't reselect a specific sequence's associated
annotation after it was used for colouring a view
-
- Hidden regions in alignment views are not
- coloured in linked structure views
-
- -
Current selection lost if popup menu
opened on a region of alignment without groups
@@ -252,38 +331,11 @@ li:before {
hidden regions results in incorrect hidden regions
-
- PCA calculation could hang when
- generating output report when working with highly
- redundant alignments
-
- -
- Cannot configure feature colours with
- lightGray or darkGray via features file
-
- -
- Overview window visible region moves
- erratically when hidden rows or columns are present
-
- -
- Per-residue colourschemes applied via the
- Structure Viewer's colour menu don't correspond to
- sequence colouring
-
- -
- Protein specific colours only offered in
- colour and group colour menu for protein alignments
-
- -
'Apply to all groups' setting when
changing colour does not apply Conservation slider value
to all groups
-
- Colour threshold slider doesn't update to
- reflect currently selected view or group's shading
- thresholds
-
- -
Percentage identity and conservation menu
items do not show a tick or allow shading to be disabled
@@ -296,17 +348,12 @@ li:before {
gaps before start of features
-
- Very large alignments take a long time to
- load
-
- -
Graduated feature colour threshold not
restored to UI when feature colour is edited
-
- Feature colour thresholds not respected
- when rendered on overview and structures when opacity at
- 100%
+ Vertical scrollbar jumps one page-width at
+ a time when scrolling vertically in wrapped mode.
-
Structure and alignment overview update
@@ -314,10 +361,6 @@ li:before {
dialog box
-
- Vertical scrollbar jumps one page-width at
- a time when scrolling vertically in wrapped mode.
-
- -
Overview window doesn't always update
when a group defined on the alignment is resized
@@ -325,41 +368,159 @@ li:before {
Mouseovers on left/right scale region in
wrapped view result in positional status updates
+
-
- Status bar shows position for ambiguous
- amino acid and nucleotide symbols
+ Status bar doesn't show position for
+ ambiguous amino acid and nucleotide symbols
-
Copy consensus sequence failed if
alignment included gapped columns
-
+ Minimum size set for Jalview windows so
+ widgets don't permanently disappear
+
+ -
+ Cannot select or filter quantitative
+ annotation that are shown only as column labels (e.g.
+ T-Coffee column reliability scores)
+
+ -
+ Exception thrown if trying to create a
+ sequence feature on gaps only
+
+ -
+ Features created with 'New feature'
+ button from a Find inherit previously defined feature type
+ rather than the Find query string
+
+ -
+ incorrect title in output window when
+ exporting tree calculated in Jalview
+
+ -
+ Hiding sequences at bottom of alignment
+ and then revealing them reorders sequences on the
+ alignment
+
+ -
+ Group panel in sequence feature settings
+ doesn't update to reflect available set of groups after
+ interactively adding or modifying features
+
+ -
+ Sequence Database chooser unusable on
+ Linux
+
+ -
+ Hide insertions in PopUp->Selection menu
+ only excluded gaps in current sequence and ignored
+ selection.
+
+
+ Rendering
+
+ -
+ Overview window visible region moves
+ erratically when hidden rows or columns are present
+
+ -
+ Per-residue colourschemes applied via the
+ Structure Viewer's colour menu don't correspond to
+ sequence colouring
+
+ -
+ Protein specific colours only offered in
+ colour and group colour menu for protein alignments
+
+ -
+ Colour threshold slider doesn't update to
+ reflect currently selected view or group's shading
+ thresholds
+
+ -
+ Feature colour thresholds not respected
+ when rendered on overview and structures when opacity at
+ 100%
+
+ -
User defined gap colour not shown in
overview when features overlaid on alignment
+
+ Data import/export
+
+ -
+ Very large alignments take a long time to
+ load
+
-
-
+ Per-sequence RNA secondary structures
+ added after a sequence was imported are not written to
+ Stockholm File
-
-
+ WUSS notation for simple pseudoknots lost
+ when importing RNA secondary structure via Stockholm
-
-
+ Secondary structure arrows for [] and {}
+ not shown in correct direction for simple pseudoknots
-
-
+ Cannot configure feature colours
+ with lightGray or darkGray via features file (but can
+ specify lightgray)
+
+ -
+ Above PID colour threshold not recovered
+ when alignment view imported from project
+
+ -
+ No mappings generated between
+ structure and sequences extracted from structure files
+ imported via URL and viewed in Jmol
+
+ -
+ Structures loaded via URL are saved in
+ Jalview Projects rather than fetched via URL again when
+ the project is loaded and the structure viewed
- Documentation
+ Web Services
-
- Release notes reformatted for readibility
- with the built-in Java help viewer
+ EnsemblGenomes example failing after
+ release of Ensembl v.88
+
+ -
+ Proxy server address and port always
+ appear enabled in Preferences->Connections
+
+ -
+ DAS registry not found exceptions
+ removed from console output
+
+ -
+ Cannot retrieve protein products from
+ Ensembl by Peptide ID
+
+ -
+ Incorrect PDB-Uniprot mappings
+ created from SIFTs, and spurious 'Couldn't open structure
+ in Chimera' errors raised after April 2017 update (problem
+ due to 'null' string rather than empty string used for
+ residues with no corresponding PDB mapping).
- Application
+ Application UI
-
+ User Defined Colours not added to Colour
+ menu
+
+ -
Easier creation of colours for all 'Lower
case' residues (button in colourscheme editor debugged and
new documentation and tooltips added)
@@ -373,12 +534,17 @@ li:before {
new features are added to alignment
-
- Structure viewer's View -> Colour By view
- selection menu changes colours of alignment views
+ Cancel in feature settings reverts
+ changes to feature colours via the Amend features dialog
-
- Proxy server address and port always
- appear enabled in Preferences->Connections
+ Null pointer exception when attempting to
+ edit graduated feature colour via amend features dialog
+ box
+
+ -
+ Structure viewer's View -> Colour By view
+ selection menu changes colours of alignment views
-
Spurious exceptions in console raised
@@ -398,24 +564,6 @@ li:before {
shown again after pressing 'Cancel'
-
- DAS registry not found exceptions
- removed from console output
-
- -
- Above PID colour threshold not recovered
- when alignment view imported from project
-
- -
- No mappings generated between structure
- and sequences extracted from structure files imported via
- URL
-
- -
- Structures loaded via URL are saved in
- Jalview Projects rather than fetched via URL again when
- the project is loaded and the structure viewed
-
- -
Trackpad horizontal scroll gesture
adjusts start position in wrap mode
@@ -424,31 +572,18 @@ li:before {
ambiguous amino acids
-
- Hide insertions in PopUp menu excludes
- gaps in selection, current sequence and only within
- selected columns
-
- -
- Cannot retrieve protein products from
- Ensembl by Peptide ID
-
- -
cDNA Consensus annotation not shown in
CDS/Protein view after CDS sequences added for aligned
proteins
-
- cDNA Consensus not shown
+ User defined colourschemes called 'User
+ Defined' don't appear in Colours menu
-
-
Applet
-
-
-
- -
Switching between Nucleotide and Protein
score models doesn't always result in an updated PCA plot
@@ -466,6 +601,23 @@ li:before {
colourscheme
+ Test Suite
+
+ -
+ Unit test failure:
+ jalview.ws.jabaws.RNAStructExportImport setup fails
+
+ -
+ Unit test failure:
+ jalview.ws.sifts.SiftsClientTest due to compatibility
+ problems with deep array comparison equality asserts in
+ successive versions of TestNG
+
+ -
+ Relocated StructureChooserTest and
+ ParameterUtilsTest Unit tests to Network suite
+
+
New Known Issues
-
@@ -475,25 +627,23 @@ li:before {
-
Importing annotation file with rows
containing just upper and lower case letters are
- interpreted as WUSS rna secondary structure symbols
+ interpreted as WUSS RNA secondary structure symbols
-
- Cannot load Newick trees from eggnog
- ortholog database
+ Cannot load and display Newick trees
+ reliably from eggnog Ortholog database
-
- Test Suite
-
-
- Unit test failure:
- jalview.ws.jabaws.RNAStructExportImport setup fails
+ Status bar shows 'Marked x columns
+ containing features of type Highlight' when 'B' is pressed
+ to mark columns containing highlighted regions.
-
-
+ Dropping a PDB file onto a sequence
+ doesn't always add secondary structure annotation.
- |