Release History

+ General +

- + Fixed incorrect value in BLOSUM 62 score + matrix - C->R should be '-3'
Old matrix restored with + this one-line groovy script:
jalview.analysis.scoremodels.ScoreModels.instance.BLOSUM62.@matrix[4][1]=3
- + Fixed Jalview's treatment of gaps in PCA + and substitution matrix based Tree calculations.
In + earlier versions of Jalview, gaps matching gaps were + penalised, and gaps matching non-gaps penalised even more. + In the PCA calculation, gaps were actually treated as + non-gaps - so different costs were applied, which meant + Jalview's PCAs were different to those produced by + SeqSpace.
Jalview now treats gaps in the same way as + SeqSpace (ie it scores them as 0). To restore pre-2.10.2 + behaviour
+ jalview.viewmodel.PCAModel.scoreGapAsAny=true // for + 2.10.1 mode
+ jalview.viewmodel.PCAModel.scoreGapAsAny=false // to + restore 2.10.2 mode

Applet +

Reopening Colour by annotation dialog doesn't reselect a specific sequence's associated annotation after it was used for colouring a view

Hidden regions in alignment views are not coloured in linked structure views

Current selection lost if popup menu opened on a region of alignment without groups

Popup menu not always shown for regions of an alignment with overlapping groups

Finder double counts if both a sequence's name and description match

Hiding column selection containing two hidden regions results in incorrect hidden regions

PCA calculation could hang when generating output report when working with highly redundant alignments

Cannot configure feature colours with lightGray or darkGray via features file

Overview window visible region moves erratically when hidden rows or columns are present

Per-residue colourschemes applied via the Structure Viewer's colour menu don't correspond to sequence colouring

Protein specific colours only offered in colour and group colour menu for protein alignments

'Apply to all groups' setting when changing colour does not apply Conservation slider value to all groups

Colour threshold slider doesn't update to reflect currently selected view or group's shading thresholds

Percentage identity and conservation menu items do not show a tick or allow shading to be disabled

Conservation shading or PID threshold lost when base colourscheme changed if slider not visible

Sequence features shown in tooltip for gaps before start of features

Very large alignments take a long time to load

Graduated feature colour threshold not restored to UI when feature colour is edited

Feature colour thresholds not respected when rendered on overview and structures when opacity at 100%

Structure and alignment overview update as graduate feature colour settings are modified via the dialog box

Vertical scrollbar jumps one page-width at a time when scrolling vertically in wrapped mode.

Overview window doesn't always update when a group defined on the alignment is resized

Mouseovers on left/right scale region in wrapped view result in positional status updates

Status bar shows position for ambiguous amino acid and nucleotide symbols

+ + Application +

Easier creation of colours for all 'Lower case' residues (button in colourscheme editor debugged and new documentation and tooltips added)
Text colour threshold's 'Cancel' button doesn't restore group-specific text colour thresholds
Feature settings panel does not update as new features are added to alignment
Structure viewer's View -> Colour By view selection menu changes colours of alignment views
Proxy server address and port always appear enabled in Preferences->Connections
Spurious exceptions in console raised from alignment calculation workers after alignment has been closed
Typo in selection popup menu - Create groups now 'Create Group'
CMD/CTRL and G or Shift G for Create/Undefine group doesn't always work
Tree Viewer's Print Dialog doesn't get shown again after pressing 'Cancel'
DAS registry not found exceptions removed from console output
Above PID colour threshold not recovered when alignment view imported from project
No mappings generated between structure and sequences extracted from structure files imported via URL
+ Structures loaded via URL are saved in + Jalview Projects rather than fetched via URL again when + the project is loaded and the structure viewed +
Trackpad horizontal scroll gesture adjusts start position in wrap mode
Status bar doesn't show positions for ambiguous amino acids
Hide insertions in PopUp menu excludes gaps in selection, current sequence and only within selected columns

+ Applet +

Features not rendered as transparent on overview or linked structure view
Colour group by conservation doesn't work (since 2.8)
Hitting Cancel after applying user-defined colourscheme doesn't restore original colourscheme

+ New Known Issues +

Protein/CDS view scrolling not always in phase after a sequence motif find operation
Importing annotation file with rows containing just upper and lower case letters are interpreted as WUSS rna secondary structure symbols
Cannot load Newick trees from eggnog ortholog database

+ +

+ General +

+ Columns with more than one modal residue + are not coloured or thresholded according to percent + identity (first observed in Jalview 2.8.2) +
+ Threonine incorrectly reported as not + hydrophobic +
+ Updates to documentation pages (above PID + threshold, amino acid properties) +
+ Lower case residues in sequences are not + reported as mapped to residues in a structure file in the + View Mapping report +
+ Identical features with non-numeric scores + could be added multiple times to a sequence +
+ Disulphide + bond features shown as two highlighted residues rather + than a range in linked structure views, and treated + correctly when selecting and computing trees from features +
+ Custom URL links for database + cross-references are matched to database name regardless + of case +

+ Application +

+ Custom URL links for specific database + names without regular expressions also offer links from + Sequence ID +
+ Removing a single configured link in the + URL links pane in Connections preferences doesn't actually + update Jalview configuration +
+ CTRL-Click on a selected region to open + the alignment area popup menu doesn't work on El-Capitan +
+ Jalview doesn't offer to associate mmCIF + files with similarly named sequences if dropped onto the + alignment +
+ Additional mappings are shown for PDB + entries where more chains exist in the PDB accession than + are reported in the SIFTS file +
+ Certain structures do not get mapped to + the structure view when displayed with Chimera +
+ No chains shown in the Chimera view + panel's View->Show Chains submenu +
+ Export as HTML with embedded SVG doesn't + work for wrapped alignment views +
+ Rename UI components for running JPred + predictions from 'JNet' to 'JPred' +
+ Export as PNG or SVG is + corrupted when annotation panel vertical scroll is not at + first annotation row +
+ Attempting to view structure for Hen + lysozyme results in a PDB Client error dialog box +
+ Structure View's mapping report switched ranges for PDB and sequence for SIFTS

+ +

General

reinstate CTRL-click for opening pop-up menu on OSX
Export features in Jalview format (again) includes graduated colourschemes
More responsive when working with big alignments and lots of hidden columns
Hidden column markers not always rendered at right of alignment window
Tidied up links in help file table of contents
Feature based tree calculation not shown for DNA alignments
Hidden columns ignored during feature based tree calculation
Alignment view stops updating when show unconserved enabled for group on alignment
Cannot insert gaps into sequence when set as reference
Alignment column in status incorrectly shown as "Sequence position" when mousing over annotation
Incorrect column numbers in ruler when hidden columns present
Colour by RNA Helices not enabled when user created annotation added to alignment
RNA Structure consensus only computed for '()' base pair annotation
Enabling 'Ignore Gaps' results in zero scores for all base pairs in RNA Structure Consensus
Extend selection with columns containing feature not working
Pfam format writer puts extra space at beginning of sequence
Incomplete sequence extracted from pdb entry 3a6s
Cannot create groups on an alignment from from a tree when t-coffee scores are shown
Cannot import and view PDB structures with chains containing negative resnums (4q4h)
ArithmeticExceptions raised when parsing some structures
'Empty' alignment blocks added to Clustal, PIR and PileUp output
Reordering sequence features that are not visible causes alignment window to repaint
Colour by conservation always enabled and no tick + shown in menu when BLOSUM or PID shading applied
FER1_ARATH and FER2_ARATH labels were switched in + example sequences/projects/trees

+ Application +

Jalview projects with views of local PDB structure + files saved on Windows cannot be opened on OSX
Multiple structure views can be opened and + superposed without timeout for structures with multiple + models or multiple sequences in alignment
Cannot import or associated local PDB files without + a PDB ID HEADER line
RMSD is not output in Jmol console when + superposition is performed
Drag and drop of URL from Browser fails for Linux + and OSX versions earlier than El Capitan
ENA client ignores invalid content from ENA server
Exceptions are not raised in console when ENA + client attempts to fetch non-existent IDs via Fetch DB + Refs UI option
Exceptions are not raised in console when a new + view is created on the alignment
OSX right-click fixed for group selections: + CMD-click to insert/remove gaps in groups and CTRL-click + to open group pop-up menu

+ Build and deployment +

URL link checker now copes with multi-line anchor + tags

+ New Known Issues +

Drag and drop from URL links in browsers do not + work on Windows

+ General +

+ reinstate CTRL-click for opening pop-up + menu on OSX +
+ Export features in Jalview format (again) + includes graduated colourschemes +
+ More responsive when + working with big alignments and lots of hidden columns +
+ Hidden column markers not always rendered + at right of alignment window +
+ Tidied up links in help file table of + contents +
+ Feature based tree calculation not shown + for DNA alignments +
+ Hidden columns ignored during feature + based tree calculation +
+ Alignment view stops updating when show + unconserved enabled for group on alignment +
+ Cannot insert gaps into sequence when + set as reference +
+ Alignment column in status incorrectly + shown as "Sequence position" when mousing over + annotation +
+ Incorrect column numbers in ruler when + hidden columns present +
+ Colour by RNA Helices not enabled when + user created annotation added to alignment +
+ RNA Structure consensus only computed for + '()' base pair annotation +
+ Enabling 'Ignore Gaps' results + in zero scores for all base pairs in RNA Structure + Consensus +
+ Extend selection with columns containing + feature not working +
+ Pfam format writer puts extra space at + beginning of sequence +
+ Incomplete sequence extracted from pdb + entry 3a6s +
+ Cannot create groups on an alignment from + from a tree when t-coffee scores are shown +
+ Cannot import and view PDB + structures with chains containing negative resnums (4q4h) +
+ ArithmeticExceptions raised when parsing + some structures +
+ 'Empty' alignment blocks added + to Clustal, PIR and PileUp output +
+ Reordering sequence features that are + not visible causes alignment window to repaint +
Threshold sliders don't work in graduated colour and colour by annotation row for e-value @@ -151,96 +708,197 @@ columns
- FER1_ARATH and FER2_ARATH mislabelled in example file (uniref50.fa, feredoxin.fa, unaligned.fa, exampleFile_2_7.jar, exampleFile.jar, exampleFile_2_3.jar) + FER1_ARATH and FER2_ARATH mislabelled in + example file (uniref50.fa, feredoxin.fa, unaligned.fa, + exampleFile_2_7.jar, exampleFile.jar, exampleFile_2_3.jar)
- Null pointer exceptions and redraw problems when reference sequence defined and 'show non-conserved' enabled + Null pointer exceptions and redraw + problems when reference sequence defined and 'show + non-conserved' enabled
Quality and Conservation are now shown on load even when Consensus calculation is disabled
- + Quality and Conservation are now shown on + load even when Consensus calculation is disabled
- -
- + Remove right on penultimate column of + alignment does nothing

Application

Corrupt preferences for SVG, EPS & HTML output when running on non-gb/us i18n platforms
URLs and links can imported by drag'n'drop on OSX webstart
InstallAnywhere distribution fails when launching Chimera
Jalview very slow to launch via webstart (also hotfix for 2.9.0b2)
Cannot save project when view has a reference sequence defined
Columns are suddenly selected in other alignments and views when revealing hidden columns
Hide columns not mirrored in complement view in a cDNA/Protein splitframe
Cannot save/restore representative sequence from project when only one sequence is represented
Disabled 'Best Uniprot Coverage' option in Structure Chooser
Modifying 'Ignore Gaps' on consensus or structure consensus didn't refresh annotation panel
View mapping in structure view shows mappings between sequence and all chains in a PDB file
PDB and Uniprot FTS dialogs format columns correctly, don't display array data, sort columns according to type
Export complete shown after destination file chooser is cancelled during an image export
Error when querying PDB Service with sequence name containing special characters
Manual PDB structure querying should be case insensitive
Large tooltips with broken HTML formatting don't wrap
Figures exported from wrapped view are truncated so L looks like I in consensus annotation
Export features should only export the currently displayed features for the current selection or view
Enable 'Get Cross-References' in menu after fetching cross-references
Mouseover of a copy of a sequence is not followed in the structure viewer
Titles for individual alignments in splitframe not restored from project
- missing autocalculated annotation at trailing end of protein alignment in transcript/product splitview when pad-gaps not enabled by default + URLs and links can't be imported by + drag'n'drop on OSX when launched via webstart (note - not + yet fixed for El Capitan) +
+ Corrupt preferences for SVG, EPS & HTML + output when running on non-gb/us i18n platforms +
+ Error thrown when exporting a view with + hidden sequences as flat-file alignment +
+ InstallAnywhere distribution fails when + launching Chimera +
+ Jalview very slow to launch via webstart + (also hotfix for 2.9.0b2) +
+ Cannot save project when view has a + reference sequence defined +
+ Columns are suddenly selected in other + alignments and views when revealing hidden columns +
+ Hide columns not mirrored in complement + view in a cDNA/Protein splitframe +
+ Cannot save/restore representative + sequence from project when only one sequence is + represented +
+ Disabled 'Best Uniprot Coverage' option + in Structure Chooser +
+ Modifying 'Ignore Gaps' on consensus or + structure consensus didn't refresh annotation panel +
+ View mapping in structure view shows + mappings between sequence and all chains in a PDB file +
+ PDB and Uniprot FTS + dialogs format columns correctly, don't display array + data, sort columns according to type +
+ Export complete shown after destination + file chooser is cancelled during an image export +
+ Error when querying PDB Service with + sequence name containing special characters
- amino acid physicochemical conservation is case dependent + Manual PDB structure querying should be + case insensitive
- RSS reader doesn't stay hidden after last article has been read (reopened issue due to internationalisation problems) + Large tooltips with broken HTML + formatting don't wrap
Only offer PDB structures in structure viewer based on sequence name, PDB and Uniprot cross-references
- No progress bar shown during export of alignment as HTML + Figures exported from wrapped view are + truncated so L looks like I in consensus annotation
- Improved warning messages when DB Ref Fetcher fails to match, or otherwise updates sequence data from external database records. + Export features should only export the + currently displayed features for the current selection or + view
- Structures not always superimposed after multiple structures are shown for one or more sequences. + Enable 'Get Cross-References' in menu + after fetching cross-references, and restoring from project
- Reference sequence characters should not be replaced with '.' when 'Show unconserved' format option is enabled. + Mouseover of a copy of a sequence is not + followed in the structure viewer
- Cannot specify chain code when entering specific PDB id for sequence + Titles for individual alignments in + splitframe not restored from project
- File->Export->.. as doesn't work when 'Export hidden sequences' is enabled, but 'export hidden columns' is disabled. + missing autocalculated annotation at + trailing end of protein alignment in transcript/product + splitview when pad-gaps not enabled by default
Best Quality option in structure chooser selects lowest rather than highest resolution structures for each sequence
- Incorrect start and end reported for PDB to sequence mapping in 'View Mappings' report + amino acid physicochemical conservation + is case dependent
- + RSS reader doesn't stay hidden after last + article has been read (reopened issue due to + internationalisation problems)
- + Only offer PDB structures in structure + viewer based on sequence name, PDB and UniProt + cross-references
+ No progress bar shown during export of + alignment as HTML +
+ Structures not always superimposed after + multiple structures are shown for one or more sequences. +
+ Reference sequence characters should not + be replaced with '.' when 'Show unconserved' format option + is enabled. +
+ Cannot specify chain code when entering + specific PDB id for sequence +
+ File->Export->.. as doesn't work when + 'Export hidden sequences' is enabled, but 'export hidden + columns' is disabled. +
+ Best Quality option in structure chooser + selects lowest rather than highest resolution structures + for each sequence +
+ Incorrect start and end reported for PDB + to sequence mapping in 'View Mappings' report +
+ Unable to read old Jalview projects that + contain non-XML data added after Jalvew wrote project. +
Newly created annotation row reorders + after clicking on it to create new annotation for a + column. +

Applet

Incorrect columns are selected when hidden columns present before start of sequence
Missing dependencies on applet pages (JSON jars)
- Overview pixel size changes when sequences are hidden in applet + Incorrect columns are selected when + hidden columns present before start of sequence +
+ Missing dependencies on applet pages + (JSON jars)
Updated instructions for applet deployment on examples pages. +
+ Overview pixel size changes when + sequences are hidden in applet +
+ Updated instructions for applet + deployment on examples pages.