X-Git-Url: http://source.jalview.org/gitweb/?a=blobdiff_plain;f=src%2Fjalview%2Fdatamodel%2FAlignedCodonFrame.java;h=d59078bb5cf50ea90338e69ae21a52fc23464d46;hb=96a5726c430b26ed83fc8ee3be0c7ea871519fa1;hp=83eeb3de75f9b46578a360a836dcc8ce6acc1bed;hpb=3d0101179759ef157b088ea135423cd909512d9f;p=jalview.git

diff --git a/src/jalview/datamodel/AlignedCodonFrame.java b/src/jalview/datamodel/AlignedCodonFrame.java
index 83eeb3d..d59078b 100644
--- a/src/jalview/datamodel/AlignedCodonFrame.java
+++ b/src/jalview/datamodel/AlignedCodonFrame.java
@@ -20,13 +20,13 @@
  */
 package jalview.datamodel;
 
-import jalview.util.MapList;
-import jalview.util.MappingUtils;
-
 import java.util.AbstractList;
 import java.util.ArrayList;
 import java.util.List;
 
+import jalview.util.MapList;
+import jalview.util.MappingUtils;
+
 /**
  * Stores mapping between the columns of a protein alignment and a DNA alignment
  * and a list of individual codon to amino acid mappings between sequences.
@@ -107,6 +107,89 @@ public class AlignedCodonFrame
     {
       return mapping;
     }
+
+    /**
+     * Returns true if the mapping covers the full length of the given sequence.
+     * This allows us to distinguish the CDS that codes for a protein from
+     * another overlapping CDS in the parent dna sequence.
+     * 
+     * @param seq
+     * @return
+     */
+    public boolean covers(SequenceI seq)
+    {
+      List<int[]> mappedRanges = null;
+      MapList mapList = mapping.getMap();
+      if (fromSeq == seq || fromSeq == seq.getDatasetSequence())
+      {
+        mappedRanges = mapList.getFromRanges();
+      }
+      else if (mapping.to == seq || mapping.to == seq.getDatasetSequence())
+      {
+        mappedRanges = mapList.getToRanges();
+      }
+      else
+      {
+        return false;
+      }
+
+      /*
+       * check that each mapped range lies within the sequence range
+       * (necessary for circular CDS - example EMBL:J03321:AAA91567)
+       * and mapped length covers (at least) sequence length
+       */
+      int length = 0;
+      for (int[] range : mappedRanges)
+      {
+        int from = Math.min(range[0], range[1]);
+        int to = Math.max(range[0], range[1]);
+        if (from < seq.getStart() || to > seq.getEnd())
+        {
+          return false;
+        }
+        length += (to - from + 1);
+      }
+      // add 1 to mapped length to allow for a mapped stop codon
+      if (length + 1 < (seq.getEnd() - seq.getStart() + 1))
+      {
+        return false;
+      }
+      return true;
+    }
+
+    /**
+     * Adds any regions mapped to or from position {@code pos} in sequence
+     * {@code seq} to the given search results
+     * 
+     * @param seq
+     * @param pos
+     * @param sr
+     */
+    public void markMappedRegion(SequenceI seq, int pos, SearchResultsI sr)
+    {
+      int[] codon = null;
+      SequenceI mappedSeq = null;
+      SequenceI ds = seq.getDatasetSequence();
+      
+      if (this.fromSeq == seq || this.fromSeq == ds)
+      {
+        codon = this.mapping.map.locateInTo(pos, pos);
+        mappedSeq = this.mapping.to;
+      }
+      else if (this.mapping.to == seq || this.mapping.to == ds)
+      {
+        codon = this.mapping.map.locateInFrom(pos, pos);
+        mappedSeq = this.fromSeq;
+      }
+
+      if (codon != null)
+      {
+        for (int i = 0; i < codon.length; i += 2)
+        {
+          sr.addResult(mappedSeq, codon[i], codon[i + 1]);
+        }
+      }
+    }
   }
 
   private List<SequenceToSequenceMapping> mappings;
@@ -116,7 +199,7 @@ public class AlignedCodonFrame
    */
   public AlignedCodonFrame()
   {
-    mappings = new ArrayList<SequenceToSequenceMapping>();
+    mappings = new ArrayList<>();
   }
 
   /**
@@ -179,7 +262,7 @@ public class AlignedCodonFrame
   {
     // TODO return a list instead?
     // return dnaSeqs;
-    List<SequenceI> seqs = new ArrayList<SequenceI>();
+    List<SequenceI> seqs = new ArrayList<>();
     for (SequenceToSequenceMapping ssm : mappings)
     {
       seqs.add(ssm.fromSeq);
@@ -190,7 +273,7 @@ public class AlignedCodonFrame
   public SequenceI[] getAaSeqs()
   {
     // TODO not used - remove?
-    List<SequenceI> seqs = new ArrayList<SequenceI>();
+    List<SequenceI> seqs = new ArrayList<>();
     for (SequenceToSequenceMapping ssm : mappings)
     {
       seqs.add(ssm.mapping.to);
@@ -200,7 +283,7 @@ public class AlignedCodonFrame
 
   public MapList[] getdnaToProt()
   {
-    List<MapList> maps = new ArrayList<MapList>();
+    List<MapList> maps = new ArrayList<>();
     for (SequenceToSequenceMapping ssm : mappings)
     {
       maps.add(ssm.mapping.map);
@@ -210,7 +293,7 @@ public class AlignedCodonFrame
 
   public Mapping[] getProtMappings()
   {
-    List<Mapping> maps = new ArrayList<Mapping>();
+    List<Mapping> maps = new ArrayList<>();
     for (SequenceToSequenceMapping ssm : mappings)
     {
       maps.add(ssm.mapping);
@@ -220,7 +303,7 @@ public class AlignedCodonFrame
 
   /**
    * Returns the first mapping found which is to or from the given sequence, or
-   * null.
+   * null if none is found
    * 
    * @param seq
    * @return
@@ -261,9 +344,12 @@ public class AlignedCodonFrame
   }
 
   /**
+   * Return the corresponding aligned or dataset dna sequence for given amino
+   * acid sequence, or null if not found. returns the sequence from the first
+   * mapping found that involves the protein sequence.
    * 
-   * @param sequenceRef
-   * @return null or corresponding aaSeq entry for dnaSeq entry
+   * @param aaSeqRef
+   * @return
    */
   public SequenceI getDnaForAaSeq(SequenceI aaSeqRef)
   {
@@ -304,34 +390,10 @@ public class AlignedCodonFrame
   public void markMappedRegion(SequenceI seq, int index,
           SearchResultsI results)
   {
-    int[] codon;
     SequenceI ds = seq.getDatasetSequence();
     for (SequenceToSequenceMapping ssm : mappings)
     {
-      if (ssm.fromSeq == seq || ssm.fromSeq == ds)
-      {
-        codon = ssm.mapping.map.locateInTo(index, index);
-        if (codon != null)
-        {
-          for (int i = 0; i < codon.length; i += 2)
-          {
-            results.addResult(ssm.mapping.to, codon[i], codon[i + 1]);
-          }
-        }
-      }
-      else if (ssm.mapping.to == seq || ssm.mapping.to == ds)
-      {
-        {
-          codon = ssm.mapping.map.locateInFrom(index, index);
-          if (codon != null)
-          {
-            for (int i = 0; i < codon.length; i += 2)
-            {
-              results.addResult(ssm.fromSeq, codon[i], codon[i + 1]);
-            }
-          }
-        }
-      }
+      ssm.markMappedRegion(ds, index, results);
     }
   }
 
@@ -485,7 +547,7 @@ public class AlignedCodonFrame
   {
     MapList ml = null;
     SequenceI dnaSeq = null;
-    List<char[]> result = new ArrayList<char[]>();
+    List<char[]> result = new ArrayList<>();
 
     for (SequenceToSequenceMapping ssm : mappings)
     {
@@ -505,12 +567,11 @@ public class AlignedCodonFrame
          * Read off the mapped nucleotides (converting to position base 0)
          */
         codonPos = MappingUtils.flattenRanges(codonPos);
-        char[] dna = dnaSeq.getSequence();
         int start = dnaSeq.getStart();
-        result.add(
-                new char[]
-                { dna[codonPos[0] - start], dna[codonPos[1] - start],
-                    dna[codonPos[2] - start] });
+        char c1 = dnaSeq.getCharAt(codonPos[0] - start);
+        char c2 = dnaSeq.getCharAt(codonPos[1] - start);
+        char c3 = dnaSeq.getCharAt(codonPos[2] - start);
+        result.add(new char[] { c1, c2, c3 });
       }
     }
     return result.isEmpty() ? null : result;
@@ -525,8 +586,8 @@ public class AlignedCodonFrame
    */
   public List<Mapping> getMappingsFromSequence(SequenceI seq)
   {
-    List<Mapping> result = new ArrayList<Mapping>();
-    List<SequenceI> related = new ArrayList<SequenceI>();
+    List<Mapping> result = new ArrayList<>();
+    List<SequenceI> related = new ArrayList<>();
     SequenceI seqDs = seq.getDatasetSequence();
     seqDs = seqDs != null ? seqDs : seq;
 
@@ -768,7 +829,7 @@ public class AlignedCodonFrame
    * Two AlignedCodonFrame objects are equal if they hold the same ordered list
    * of mappings
    * 
-   * @see SequenceToSequenceMapping#
+   * @see SequenceToSequenceMapping#equals
    */
   @Override
   public boolean equals(Object obj)
@@ -784,4 +845,55 @@ public class AlignedCodonFrame
   {
     return mappings;
   }
+
+  /**
+   * Returns the first mapping found which is between the two given sequences,
+   * and covers the full extent of both.
+   * 
+   * @param seq1
+   * @param seq2
+   * @return
+   */
+  public SequenceToSequenceMapping getCoveringMapping(SequenceI seq1,
+          SequenceI seq2)
+  {
+    for (SequenceToSequenceMapping mapping : mappings)
+    {
+      if (mapping.covers(seq2) && mapping.covers(seq1))
+      {
+        return mapping;
+      }
+    }
+    return null;
+  }
+
+  /**
+   * Returns the first mapping found which is between the given sequence and
+   * another, is a triplet mapping (3:1 or 1:3), and covers the full extent of
+   * both sequences involved.
+   * 
+   * @param seq
+   * @return
+   */
+  public SequenceToSequenceMapping getCoveringCodonMapping(SequenceI seq)
+  {
+    for (SequenceToSequenceMapping mapping : mappings)
+    {
+      if (mapping.getMapping().getMap().isTripletMap()
+              && mapping.covers(seq))
+      {
+        if (mapping.fromSeq == seq
+                && mapping.covers(mapping.getMapping().getTo()))
+        {
+          return mapping;
+        }
+        else if (mapping.getMapping().getTo() == seq
+                && mapping.covers(mapping.fromSeq))
+        {
+          return mapping;
+        }
+      }
+    }
+    return null;
+  }
 }