X-Git-Url: http://source.jalview.org/gitweb/?a=blobdiff_plain;f=src%2Fjalview%2Fdatamodel%2FAlignment.java;h=3689433aefcdcba248a8c16fdb0d005f187a436f;hb=9efc6af45120e24f7a11cc8ce6409139844e5001;hp=8c320f75ca02c8f27a3791b5efa816952dea49c4;hpb=e33cdacd2ac2836504375c538574a0f1cafec7e3;p=jalview.git

diff --git a/src/jalview/datamodel/Alignment.java b/src/jalview/datamodel/Alignment.java
index 8c320f7..3689433 100755
--- a/src/jalview/datamodel/Alignment.java
+++ b/src/jalview/datamodel/Alignment.java
@@ -1,6 +1,6 @@
 /*
  * Jalview - A Sequence Alignment Editor and Viewer
- * Copyright (C) 2005 AM Waterhouse, J Procter, G Barton, M Clamp, S Searle
+ * Copyright (C) 2007 AM Waterhouse, J Procter, G Barton, M Clamp, S Searle
  *
  * This program is free software; you can redistribute it and/or
  * modify it under the terms of the GNU General Public License
@@ -18,802 +18,820 @@
  */
 package jalview.datamodel;
 
-import jalview.analysis.*;
-
-import jalview.util.*;
-
 import java.util.*;
 
+import jalview.analysis.*;
+
 /** Data structure to hold and manipulate a multiple sequence alignment
  */
-public class Alignment implements AlignmentI
+public class Alignment
+    implements AlignmentI
 {
-    protected Alignment dataset;
-    protected Vector sequences;
-    protected Vector groups = new Vector();
-    protected char gapCharacter = '-';
-    protected int type = NUCLEOTIDE;
-    public static final int PROTEIN = 0;
-    public static final int NUCLEOTIDE = 1;
+  protected Alignment dataset;
+  protected Vector sequences;
+  protected Vector groups = new Vector();
+  protected char gapCharacter = '-';
+  protected int type = NUCLEOTIDE;
+  public static final int PROTEIN = 0;
+  public static final int NUCLEOTIDE = 1;
 
-    /** DOCUMENT ME!! */
-    public AlignmentAnnotation[] annotations;
+  /** DOCUMENT ME!! */
+  public AlignmentAnnotation[] annotations;
 
-    HiddenSequences hiddenSequences = new HiddenSequences(this);
+  HiddenSequences hiddenSequences = new HiddenSequences(this);
 
-    private void initAlignment(SequenceI[] seqs) {
-      int i=0;
+  public Hashtable alignmentProperties;
 
-      if( jalview.util.Comparison.isNucleotide(seqs))
-        type = NUCLEOTIDE;
-      else
-        type = PROTEIN;
-
-      sequences = new Vector();
-
-      for (i = 0; i < seqs.length; i++)
-      {
-        sequences.addElement(seqs[i]);
-      }
+  private void initAlignment(SequenceI[] seqs)
+  {
+    int i = 0;
 
+    if (jalview.util.Comparison.isNucleotide(seqs))
+    {
+      type = NUCLEOTIDE;
     }
-    /** Make an alignment from an array of Sequences.
-     *
-     * @param sequences
-     */
-    public Alignment(SequenceI[] seqs)
+    else
     {
-      initAlignment(seqs);
+      type = PROTEIN;
     }
-    /**
-     * Make a new alignment from an array of SeqCigars
-     * @param seqs SeqCigar[]
-     */
-    public Alignment(SeqCigar[] alseqs) {
 
-      SequenceI[] seqs = new SequenceI[alseqs.length];
-      for (int i=0; i<alseqs.length; i++) {
-        seqs[i] = alseqs[i].getSeq(this.gapCharacter);
-      }
-      initAlignment(seqs);
+    sequences = new Vector();
+
+    for (i = 0; i < seqs.length; i++)
+    {
+      sequences.addElement(seqs[i]);
     }
-    /**
-     * Make a new alignment from an CigarArray
-     * JBPNote - can only do this when compactAlignment does not contain hidden regions.
-     * JBPNote - must also check that compactAlignment resolves to a set of SeqCigars - or construct them appropriately.
-     * @param compactAlignment CigarArray
-     */
-    public Alignment(CigarArray compactAlignment) {
-      throw new Error("Alignment(CigarArray) not yet implemented");
-      // this(compactAlignment.refCigars);
+
+  }
+
+  /** Make an alignment from an array of Sequences.
+   *
+   * @param sequences
+   */
+  public Alignment(SequenceI[] seqs)
+  {
+    initAlignment(seqs);
+  }
+
+  /**
+   * Make a new alignment from an array of SeqCigars
+   * @param seqs SeqCigar[]
+   */
+  public Alignment(SeqCigar[] alseqs)
+  {
+    SequenceI[] seqs = SeqCigar.createAlignmentSequences(alseqs, gapCharacter,
+        new ColumnSelection(), null);
+    initAlignment(seqs);
+  }
+
+  /**
+   * Make a new alignment from an CigarArray
+   * JBPNote - can only do this when compactAlignment does not contain hidden regions.
+   * JBPNote - must also check that compactAlignment resolves to a set of SeqCigars - or construct them appropriately.
+   * @param compactAlignment CigarArray
+   */
+  public static AlignmentI createAlignment(CigarArray compactAlignment)
+  {
+    throw new Error("Alignment(CigarArray) not yet implemented");
+    // this(compactAlignment.refCigars);
+  }
+
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public Vector getSequences()
+  {
+    return sequences;
+  }
+
+  public SequenceI[] getSequencesArray()
+  {
+    if (sequences==null)
+      return null;
+    SequenceI[] reply = new SequenceI[sequences.size()];
+    for (int i = 0; i < sequences.size(); i++)
+    {
+      reply[i] = (SequenceI) sequences.elementAt(i);
     }
+    return reply;
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public Vector getSequences()
+  /**
+   * DOCUMENT ME!
+   *
+   * @param i DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public SequenceI getSequenceAt(int i)
+  {
+    if (i < sequences.size())
     {
-        return sequences;
+      return (SequenceI) sequences.elementAt(i);
     }
 
-    public SequenceI [] getSequencesArray()
+    return null;
+  }
+
+  /** Adds a sequence to the alignment.  Recalculates maxLength and size.
+   *
+   * @param snew
+   */
+  public void addSequence(SequenceI snew)
+  {
+    if (dataset != null)
     {
-      SequenceI [] reply = new SequenceI[sequences.size()];
-      for(int i=0; i<sequences.size(); i++)
+      // maintain dataset integrity
+      if (snew.getDatasetSequence() != null)
+      {
+        getDataset().addSequence(snew.getDatasetSequence());
+      }
+      else
       {
-        reply[i] = (SequenceI)sequences.elementAt(i);
+        // derive new sequence
+        SequenceI adding = snew.deriveSequence();
+        getDataset().addSequence(adding.getDatasetSequence());
+        snew = adding;
       }
-      return reply;
     }
+    if (sequences==null) {
+      initAlignment(new SequenceI[] { snew });
+    } else {
+      sequences.addElement(snew);
+    }
+    if (hiddenSequences!=null)
+      hiddenSequences.adjustHeightSequenceAdded();
+  }
+
+  /** Adds a sequence to the alignment.  Recalculates maxLength and size.
+   *
+   * @param snew
+   */
+  public void setSequenceAt(int i, SequenceI snew)
+  {
+    SequenceI oldseq = getSequenceAt(i);
+    deleteSequence(oldseq);
+
+    sequences.setElementAt(snew, i);
+  }
+
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public Vector getGroups()
+  {
+    return groups;
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param i DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public SequenceI getSequenceAt(int i)
+  public void finalize()
+  {
+    if(getDataset()!=null)
+      getDataset().removeAlignmentRef();
+
+    dataset = null;
+    sequences = null;
+    groups = null;
+    annotations = null;
+    hiddenSequences = null;
+  }
+
+  /**
+   * decrement the alignmentRefs counter by one and call finalize if it goes to zero.
+   */
+  private void removeAlignmentRef()
+  {
+    if (--alignmentRefs==0)
     {
-        if (i < sequences.size())
-        {
-            return (SequenceI) sequences.elementAt(i);
-        }
+      finalize();
+    }
+  }
+
+  /**
+   * DOCUMENT ME!
+   *
+   * @param s DOCUMENT ME!
+   */
+  public void deleteSequence(SequenceI s)
+  {
+    deleteSequence(findIndex(s));
+  }
 
-        return null;
+  /**
+   * DOCUMENT ME!
+   *
+   * @param i DOCUMENT ME!
+   */
+  public void deleteSequence(int i)
+  {
+    if (i > -1 && i < getHeight())
+    {
+      sequences.removeElementAt(i);
+      hiddenSequences.adjustHeightSequenceDeleted(i);
     }
+  }
 
-    /** Adds a sequence to the alignment.  Recalculates maxLength and size.
-     *
-     * @param snew
-     */
-    public void addSequence(SequenceI snew)
+  /**    */
+  public SequenceGroup findGroup(SequenceI s)
+  {
+    for (int i = 0; i < this.groups.size(); i++)
     {
-      if(dataset!=null)
+      SequenceGroup sg = (SequenceGroup) groups.elementAt(i);
+
+      if (sg.getSequences(null).contains(s))
       {
-        if(snew.getDatasetSequence()!=null)
-        {
-          System.out.println(snew.getName());
-          getDataset().addSequence(snew.getDatasetSequence());
-        }
-        else
-        {
-          Sequence ds = new Sequence(snew.getName(),
-                                     AlignSeq.extractGaps("-. ",
-              snew.getSequence()),
-                                     snew.getStart(),
-                                     snew.getEnd());
-
-          snew.setDatasetSequence(ds);
-          getDataset().addSequence(ds);
-        }
+        return sg;
       }
-
-      sequences.addElement(snew);
     }
 
+    return null;
+  }
+
+  /**
+   * DOCUMENT ME!
+   *
+   * @param s DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public SequenceGroup[] findAllGroups(SequenceI s)
+  {
+    Vector temp = new Vector();
 
-    /** Adds a sequence to the alignment.  Recalculates maxLength and size.
-     *
-     * @param snew
-     */
-    public void setSequenceAt(int i, SequenceI snew)
+    int gSize = groups.size();
+    for (int i = 0; i < gSize; i++)
     {
-        SequenceI oldseq = getSequenceAt(i);
-        deleteSequence(oldseq);
+      SequenceGroup sg = (SequenceGroup) groups.elementAt(i);
+      if (sg == null || sg.getSequences(null) == null)
+      {
+        this.deleteGroup(sg);
+        gSize--;
+        continue;
+      }
 
-        sequences.setElementAt(snew, i);
+      if (sg.getSequences(null).contains(s))
+      {
+        temp.addElement(sg);
+      }
     }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public Vector getGroups()
+    SequenceGroup[] ret = new SequenceGroup[temp.size()];
+
+    for (int i = 0; i < temp.size(); i++)
     {
-        return groups;
+      ret[i] = (SequenceGroup) temp.elementAt(i);
     }
 
-    /** Takes out columns consisting entirely of gaps (-,.," ")
-     */
-    public void removeGaps()
-    {
-        SequenceI[] seqs = getVisibleAndRepresentedSeqs();
-        int j, jSize = seqs.length;
+    return ret;
+  }
 
-        int width = 0;
-        for (int i = 0; i < jSize; i++)
+  /**    */
+  public void addGroup(SequenceGroup sg)
+  {
+    if (!groups.contains(sg))
+    {
+      if (hiddenSequences.getSize() > 0)
+      {
+        int i, iSize = sg.getSize();
+        for (i = 0; i < iSize; i++)
         {
-          if (seqs[i].getLength() > width)
+          if (!sequences.contains(sg.getSequenceAt(i)))
           {
-            width = seqs[i].getLength();
+            sg.deleteSequence(sg.getSequenceAt(i), false);
+            iSize--;
+            i--;
           }
         }
 
-        int startCol = -1, endCol = -1;
-        boolean delete = true;
-        for (int i = 0; i < width; i++)
+        if (sg.getSize() < 1)
         {
-            delete = true;
-
-            for (j = 0; j < jSize; j++)
-            {
-                if (seqs[j].getLength() > i)
-                {
-                    if (!jalview.util.Comparison.isGap(seqs[j].getCharAt(i)))
-                    {
-                        if(delete)
-                          endCol = i;
-
-                        delete = false;
-                        break;
-                    }
-                }
-            }
-
-            if(delete && startCol==-1)
-            {
-              startCol = i;
-            }
-
-
-            if (!delete && startCol > -1)
-            {
-              deleteColumns(seqs, startCol, endCol);
-              width -= (endCol - startCol);
-              i -= (endCol - startCol);
-              startCol = -1;
-              endCol = -1;
-            }
+          return;
         }
+      }
 
-        if (delete && startCol > -1)
-        {
-          deleteColumns(seqs, startCol, endCol);
-        }
+      groups.addElement(sg);
     }
+  }
 
-    /** Removes a range of columns (start to end inclusive).
-     *
-     * @param seqs Sequences to remove columns from
-     * @param start Start column in the alignment
-     * @param end End column in the alignment
-     */
-    public void deleteColumns(SequenceI [] seqs, int start, int end)
+  /**
+   * DOCUMENT ME!
+   */
+  public void deleteAllGroups()
+  {
+    groups.removeAllElements();
+  }
+
+  /**    */
+  public void deleteGroup(SequenceGroup g)
+  {
+    if (groups.contains(g))
     {
-      for(int i=0; i<seqs.length; i++)
-        seqs[i].deleteChars(start, end);
+      groups.removeElement(g);
     }
+  }
 
+  /**    */
+  public SequenceI findName(String name)
+  {
+    return findName(name,false);
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param i DOCUMENT ME!
-     */
-    public void trimLeft(int i)
-    {
-        SequenceI[] seqs = getVisibleAndRepresentedSeqs();
-        int j, jSize = seqs.length;
-        for (j = 0; j < jSize; j++)
-        {
-            int newstart = seqs[j].findPosition(i);
-
-            if(i>seqs[j].getLength())
-            {
-              sequences.removeElement(seqs[j]);
-              j--;
-              jSize--;
-            }
-            else
-            {
-              seqs[j].setStart(newstart);
-              seqs[j].setSequence(seqs[j].getSequence().substring(i));
-            }
-        }
-    }
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#findName(java.lang.String, boolean)
+   */
+  public SequenceI findName(String token, boolean b)
+  {
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param i DOCUMENT ME!
-     */
-    public void trimRight(int i)
+    int i = 0;
+    SequenceI sq=null;
+    String sqname=null;
+    while (i < sequences.size())
     {
-        SequenceI[] seqs = getVisibleAndRepresentedSeqs();
-        int j, jSize = seqs.length;
-        for (j = 0; j < jSize; j++)
-        {
-            int newend = seqs[j].findPosition(i);
+      sq = getSequenceAt(i);
+      sqname = sq.getName();
+      if (sqname.equals(token) // exact match
+          || (b && // allow imperfect matches - case varies 
+              (sqname.equalsIgnoreCase(token))))
+      {
+        return getSequenceAt(i);
+      }
 
-            seqs[j].setEnd(newend);
-            if(seqs[j].getLength()>i)
-              seqs[j].setSequence(seqs[j].getSequence().substring(0, i + 1));
-        }
+      i++;
     }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param s DOCUMENT ME!
-     */
-    public void deleteSequence(SequenceI s)
+    return null;
+  }
+  public SequenceI[] findSequenceMatch(String name)
+  {
+    Vector matches = new Vector();
+    int i = 0;
+
+    while (i < sequences.size())
     {
-        for (int i = 0; i < getHeight(); i++)
-        {
-            if (getSequenceAt(i) == s)
-            {
-                deleteSequence(i);
-            }
-        }
+      if (getSequenceAt(i).getName().equals(name))
+      {
+        matches.addElement(getSequenceAt(i));
+      }
+      i++;
     }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param i DOCUMENT ME!
-     */
-    public void deleteSequence(int i)
+    SequenceI[] result = new SequenceI[matches.size()];
+    for (i = 0; i < result.length; i++)
     {
-        sequences.removeElementAt(i);
+      result[i] = (SequenceI) matches.elementAt(i);
     }
 
+    return result;
 
-    /**    */
-    public SequenceGroup findGroup(SequenceI s)
-    {
-        for (int i = 0; i < this.groups.size(); i++)
-        {
-            SequenceGroup sg = (SequenceGroup) groups.elementAt(i);
-
-            if (sg.getSequences(false).contains(s))
-            {
-                return sg;
-            }
-        }
+  }
 
-        return null;
-    }
+  /**    */
+  public int findIndex(SequenceI s)
+  {
+    int i = 0;
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param s DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public SequenceGroup[] findAllGroups(SequenceI s)
+    while (i < sequences.size())
     {
-        Vector temp = new Vector();
+      if (s == getSequenceAt(i))
+      {
+        return i;
+      }
 
-        int gSize = groups.size();
-        for (int i = 0; i < gSize; i++)
-        {
-            SequenceGroup sg = (SequenceGroup) groups.elementAt(i);
-            if(sg==null || sg.getSequences(false)==null)
-            {
-              this.deleteGroup(sg);
-              gSize--;
-              continue;
-            }
-
-            if (sg.getSequences(false).contains(s))
-            {
-                temp.addElement(sg);
-            }
-        }
+      i++;
+    }
 
-        SequenceGroup[] ret = new SequenceGroup[temp.size()];
+    return -1;
+  }
 
-        for (int i = 0; i < temp.size(); i++)
-        {
-            ret[i] = (SequenceGroup) temp.elementAt(i);
-        }
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public int getHeight()
+  {
+    return sequences.size();
+  }
 
-        return ret;
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public int getWidth()
+  {
+    int maxLength = -1;
+
+    for (int i = 0; i < sequences.size(); i++)
+    {
+      if (getSequenceAt(i).getLength() > maxLength)
+      {
+        maxLength = getSequenceAt(i).getLength();
+      }
     }
 
+    return maxLength;
+  }
 
+  /**
+   * DOCUMENT ME!
+   *
+   * @param gc DOCUMENT ME!
+   */
+  public void setGapCharacter(char gc)
+  {
+    gapCharacter = gc;
 
-    /**    */
-    public void addGroup(SequenceGroup sg)
+    for (int i = 0; i < sequences.size(); i++)
     {
-        if (!groups.contains(sg))
-        {
-            groups.addElement(sg);
-        }
+      Sequence seq = (Sequence) sequences.elementAt(i);
+      seq.setSequence(seq.getSequenceAsString()
+                      .replace('.', gc)
+                      .replace('-', gc)
+                      .replace(' ', gc)
+          );
     }
+  }
 
-    /**
-     * DOCUMENT ME!
-     */
-    public void deleteAllGroups()
-    {
-        groups.removeAllElements();
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public char getGapCharacter()
+  {
+    return gapCharacter;
+  }
 
-        int i = 0;
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public boolean isAligned()
+  {
+    int width = getWidth();
 
-        while (i < sequences.size())
-        {
-            SequenceI s = getSequenceAt(i);
-            s.setColor(java.awt.Color.white);
-            i++;
-        }
+    for (int i = 0; i < sequences.size(); i++)
+    {
+      if (getSequenceAt(i).getLength() != width)
+      {
+        return false;
+      }
     }
 
-    /**    */
-    public void deleteGroup(SequenceGroup g)
+    return true;
+  }
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#deleteAnnotation(jalview.datamodel.AlignmentAnnotation)
+   */
+  public boolean deleteAnnotation(AlignmentAnnotation aa)
+  {
+    int aSize = 1;
+
+    if (annotations != null)
     {
-        if (groups.contains(g))
-        {
-            groups.removeElement(g);
-        }
+      aSize = annotations.length;
     }
 
-    /**    */
-    public SequenceI findName(String name)
+    if (aSize < 1)
     {
-        int i = 0;
+      return false;
+    }
 
-        while (i < sequences.size())
-        {
-            if (getSequenceAt(i).getName().equals(name))
-            {
-                return getSequenceAt(i);
-            }
+    AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize - 1];
 
-            i++;
-        }
+    boolean swap=false;
+    int tIndex = 0;
 
-        return null;
+    for (int i = 0; i < aSize; i++)
+    {
+      if (annotations[i] == aa)
+      {
+        swap=true;
+        continue;
+      }
+      if (tIndex<temp.length)
+        temp[tIndex++] = annotations[i];
     }
 
-
-    /**    */
-    public int findIndex(SequenceI s)
+    if (swap)
     {
-        int i = 0;
-
-        while (i < sequences.size())
-        {
-            if (s == getSequenceAt(i))
-            {
-                return i;
-            }
-
-            i++;
-        }
-
-        return -1;
+      annotations = temp;
+      if(aa.sequenceRef!=null)
+        aa.sequenceRef.removeAlignmentAnnotation(aa);
     }
+    return swap;
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public int getHeight()
+  /**
+   * DOCUMENT ME!
+   *
+   * @param aa DOCUMENT ME!
+   */
+  public void addAnnotation(AlignmentAnnotation aa)
+  {
+    int aSize = 1;
+    if (annotations != null)
     {
-        return sequences.size();
+      aSize = annotations.length + 1;
     }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public int getWidth()
-    {
-        int maxLength = -1;
+    AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize];
 
-        for (int i = 0; i < sequences.size(); i++)
-        {
-            if (getSequenceAt(i).getLength() > maxLength)
-            {
-                maxLength = getSequenceAt(i).getLength();
-            }
-        }
+    temp[aSize - 1] = aa;
 
-        return maxLength;
-    }
+    int i = 0;
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public int getMaxIdLength()
+    if (aSize > 1)
     {
-        int max = 0;
-        int i = 0;
+      for (i = 0; i < (aSize - 1); i++)
+      {
+        temp[i] = annotations[i];
+      }
+    }
 
-        while (i < sequences.size())
-        {
-            SequenceI seq = getSequenceAt(i);
-            String tmp = seq.getName() + "/" + seq.getStart() + "-" +
-                seq.getEnd();
+    annotations = temp;
+  }
 
-            if (tmp.length() > max)
-            {
-                max = tmp.length();
-            }
+  public void setAnnotationIndex(AlignmentAnnotation aa, int index)
+  {
+    if (aa == null || annotations == null || annotations.length - 1 < index)
+    {
+      return;
+    }
 
-            i++;
-        }
+    int aSize = annotations.length;
+    AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize];
 
-        return max;
-    }
+    temp[index] = aa;
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param gc DOCUMENT ME!
-     */
-    public void setGapCharacter(char gc)
+    for (int i = 0; i < aSize; i++)
     {
-        gapCharacter = gc;
+      if (i == index)
+      {
+        continue;
+      }
 
-        for (int i = 0; i < sequences.size(); i++)
-        {
-            Sequence seq = (Sequence) sequences.elementAt(i);
-            seq.setSequence( seq.getSequence().replace('.', gc) );
-            seq.setSequence( seq.getSequence().replace('-', gc) );
-            seq.setSequence( seq.getSequence().replace(' ', gc) );
-        }
+      if (i < index)
+      {
+        temp[i] = annotations[i];
+      }
+      else
+      {
+        temp[i] = annotations[i - 1];
+      }
     }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public char getGapCharacter()
+    annotations = temp;
+  }
+
+  /**
+   * DOCUMENT ME!
+   *
+   * @return DOCUMENT ME!
+   */
+  public AlignmentAnnotation[] getAlignmentAnnotation()
+  {
+    return annotations;
+  }
+
+  public void setNucleotide(boolean b)
+  {
+    if (b)
     {
-        return gapCharacter;
+      type = NUCLEOTIDE;
     }
-
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public Vector getAAFrequency()
+    else
     {
-        return AAFrequency.calculate(sequences, 0, getWidth());
+      type = PROTEIN;
     }
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public boolean isAligned()
+  public boolean isNucleotide()
+  {
+    if (type == NUCLEOTIDE)
     {
-        int width = getWidth();
-
-        for (int i = 0; i < sequences.size(); i++)
-        {
-            if (getSequenceAt(i).getLength() != width)
-            {
-                return false;
-            }
-        }
-
-        return true;
+      return true;
     }
-
-    /**
-     * DOCUMENT ME!
-     *
-     * @param aa DOCUMENT ME!
-     */
-    public void deleteAnnotation(AlignmentAnnotation aa)
+    else
     {
-        int aSize = 1;
+      return false;
+    }
+  }
 
-        if (annotations != null)
+  public void setDataset(Alignment data)
+  {
+    if (dataset == null && data == null)
+    {
+      // Create a new dataset for this alignment.
+      // Can only be done once, if dataset is not null
+      // This will not be performed
+      SequenceI[] seqs = new SequenceI[getHeight()];
+      SequenceI currentSeq;
+      for (int i = 0; i < getHeight(); i++)
+      {
+        currentSeq = getSequenceAt(i);
+        if (currentSeq.getDatasetSequence() != null)
         {
-            aSize = annotations.length;
+          seqs[i] = (Sequence) currentSeq.getDatasetSequence();
         }
-
-        AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize - 1];
-
-        int tIndex = 0;
-
-        for (int i = 0; i < aSize; i++)
+        else
         {
-            if (annotations[i] == aa)
-            {
-                continue;
-            }
-
-            temp[tIndex] = annotations[i];
-            tIndex++;
+          seqs[i] = currentSeq.createDatasetSequence();
         }
+      }
 
-        annotations = temp;
+      dataset = new Alignment(seqs);
     }
-
-
-    public void adjustSequenceAnnotations()
+    else if (dataset == null && data != null)
     {
-      if(annotations!=null)
-      {
-        for (int a = 0; a < annotations.length; a++)
-        {
-          if (annotations[a].sequenceRef != null)
-          {
-            annotations[a].adjustForAlignment();
-          }
-        }
-      }
+      dataset = data;
     }
+    dataset.addAlignmentRef();
+  }
+  /**
+   * reference count for number of alignments referencing this one.
+   */
+  int alignmentRefs=0;
+  /**
+   * increase reference count to this alignment.
+   */
+  private void addAlignmentRef()
+  {
+    alignmentRefs++;
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @param aa DOCUMENT ME!
-     */
-    public void addAnnotation(AlignmentAnnotation aa)
-    {
-        int aSize = 1;
-        if (annotations != null)
-        {
-            aSize = annotations.length + 1;
-        }
-
-        AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize];
+  public Alignment getDataset()
+  {
+    return dataset;
+  }
 
-        temp[aSize-1] = aa;
+  public boolean padGaps()
+  {
+    boolean modified = false;
 
-        int i = 0;
+    //Remove excess gaps from the end of alignment
+    int maxLength = -1;
 
-        if (aSize > 1)
+    SequenceI current;
+    for (int i = 0; i < sequences.size(); i++)
+    {
+      current = getSequenceAt(i);
+      for (int j = current.getLength(); j > maxLength; j--)
+      {
+        if (j > maxLength && !jalview.util.Comparison.isGap(
+            current.getCharAt(j)))
         {
-            for (i = 0; i < (aSize-1); i++)
-            {
-                temp[i] = annotations[i];
-            }
+          maxLength = j;
+          break;
         }
-
-        annotations = temp;
+      }
     }
 
-    public void setAnnotationIndex(AlignmentAnnotation aa, int index)
-    {
-      if(aa==null || annotations==null || annotations.length-1<index)
-        return;
-
-      int aSize = annotations.length;
-      AlignmentAnnotation[] temp = new AlignmentAnnotation[aSize];
+    maxLength++;
 
-      temp[index] = aa;
+    int cLength;
+    for (int i = 0; i < sequences.size();
+         i++)
+    {
+      current = getSequenceAt(i);
+      cLength = current.getLength();
 
-      for (int i = 0; i < aSize; i++)
+      if (cLength < maxLength)
       {
-        if(i==index)
-          continue;
-
-        if(i<index)
-          temp[i] = annotations[i];
-        else
-          temp[i] = annotations[i-1];
+        current.insertCharAt(cLength,
+                             maxLength - cLength, gapCharacter);
+        modified = true;
+      }
+      else if (current.getLength() > maxLength)
+      {
+        current.deleteChars(maxLength, current.getLength());
       }
-
-        annotations = temp;
     }
+    return modified;
+  }
 
-    /**
-     * DOCUMENT ME!
-     *
-     * @return DOCUMENT ME!
-     */
-    public AlignmentAnnotation[] getAlignmentAnnotation()
-    {
-        return annotations;
-    }
+  public HiddenSequences getHiddenSequences()
+  {
+    return hiddenSequences;
+  }
 
-    public void setNucleotide(boolean b)
+  public CigarArray getCompactAlignment()
+  {
+    SeqCigar alseqs[] = new SeqCigar[sequences.size()];
+    for (int i = 0; i < sequences.size(); i++)
     {
-      if(b)
-        type = NUCLEOTIDE;
-      else
-        type = PROTEIN;
+      alseqs[i] = new SeqCigar( (SequenceI) sequences.elementAt(i));
     }
+    CigarArray cal = new CigarArray(alseqs);
+    cal.addOperation(CigarArray.M, getWidth());
+    return cal;
+  }
 
-    public boolean isNucleotide()
-    {
-      if(type==NUCLEOTIDE)
-        return true;
-      else
-        return false;
-    }
+  public void setProperty(Object key, Object value)
+  {
+    if(alignmentProperties==null)
+      alignmentProperties = new Hashtable();
 
-    public void setDataset(Alignment data)
-    {
-      if(dataset==null && data==null)
-      {
-        // Create a new dataset for this alignment.
-        // Can only be done once, if dataset is not null
-        // This will not be performed
-        Sequence[] seqs = new Sequence[getHeight()];
-        for (int i = 0; i < getHeight(); i++)
-        {
-          if(getSequenceAt(i).getDatasetSequence()!=null)
-          {
-            seqs[i] = (Sequence)getSequenceAt(i).getDatasetSequence();
-          }
-          else
-          {
-            seqs[i] = new Sequence(getSequenceAt(i).getName(),
-                                   AlignSeq.extractGaps(
-                                       jalview.util.Comparison.GapChars,
-                                       getSequenceAt(i).getSequence()
-                                   ),
-                                   getSequenceAt(i).getStart(),
-                                   getSequenceAt(i).getEnd());
-
-            getSequenceAt(i).setDatasetSequence(seqs[i]);
-          }
-        }
+    alignmentProperties.put(key,value);
+  }
 
-        dataset = new Alignment(seqs);
-      }
-      else if(dataset==null && data!=null)
-      {
-        dataset = data;
-      }
-    }
+  public Object getProperty(Object key)
+  {
+    if(alignmentProperties!=null)
+      return alignmentProperties.get(key);
+    else
+      return null;
+  }
 
-    public Alignment getDataset()
+  public Hashtable getProperties()
+  {
+    return alignmentProperties;
+  }
+  AlignedCodonFrame[] codonFrameList=null;
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#addCodonFrame(jalview.datamodel.AlignedCodonFrame)
+   */
+  public void addCodonFrame(AlignedCodonFrame codons)
+  {
+    if (codons==null)
+      return;
+    if (codonFrameList==null)
     {
-      return dataset;
+      codonFrameList = new AlignedCodonFrame[] { codons };
+      return;
     }
+    AlignedCodonFrame[] t = new AlignedCodonFrame[codonFrameList.length+1];
+    System.arraycopy(codonFrameList, 0, t, 0, codonFrameList.length);
+    t[codonFrameList.length] = codons;
+    codonFrameList = t;
+  }
 
-    public boolean padGaps() {
-      boolean modified=false;
-
-      //Remove excess gaps from the end of alignment
-      int maxLength = -1;
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#getCodonFrame(int)
+   */
+  public AlignedCodonFrame getCodonFrame(int index)
+  {
+    return codonFrameList[index];
+  }
 
-      SequenceI current;
-      for (int i = 0; i < sequences.size(); i++)
-      {
-        current = getSequenceAt(i);
-        for (int j = current.getLength(); j > maxLength; j--)
-        {
-          if (j > maxLength && !jalview.util.Comparison.isGap(
-              current.getCharAt(j)))
-          {
-            maxLength = j;
-            break;
-          }
-        }
-      }
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#getCodonFrame(jalview.datamodel.SequenceI)
+   */
+  public AlignedCodonFrame[] getCodonFrame(SequenceI seq)
+  {
+    if (seq==null || codonFrameList==null)
+      return null;
+    Vector cframes=new Vector();
+    for (int f=0;f<codonFrameList.length; f++)
+    {
+      if (codonFrameList[f].involvesSequence(seq))
+        cframes.addElement(codonFrameList[f]);
+    }
+    if (cframes.size()==0)
+      return null;
+    AlignedCodonFrame[] cfr = new AlignedCodonFrame[cframes.size()];
+    cframes.copyInto(cfr);
+    return cfr;
+  }
 
-      maxLength++;
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#getCodonFrames()
+   */
+  public AlignedCodonFrame[] getCodonFrames()
+  {
+    return codonFrameList;
+  }
 
-      for (int i = 0; i < sequences.size();
-           i++)
+  /* (non-Javadoc)
+   * @see jalview.datamodel.AlignmentI#removeCodonFrame(jalview.datamodel.AlignedCodonFrame)
+   */
+  public boolean removeCodonFrame(AlignedCodonFrame codons)
+  {
+    if (codons==null || codonFrameList==null)
+      return false;
+    boolean removed=false;
+    int i=0,iSize=codonFrameList.length;
+    while (i<iSize)
+    {
+      if (codonFrameList[i]==codons)
       {
-        current = getSequenceAt(i);
-
-        if (current.getLength() < maxLength)
-        {
-          current.insertCharAt(maxLength - 1, gapCharacter);
-          modified=true;
-        }
-        else if(current.getLength() > maxLength)
+        removed=true;
+        if (i+1<iSize)
         {
-          current.deleteChars(maxLength, current.getLength());
+          System.arraycopy(codonFrameList,i+1,codonFrameList, i, iSize-i-1);
         }
+        iSize--;
       }
-      return modified;
-    }
-
-    public HiddenSequences getHiddenSequences()
-    {
-      return hiddenSequences;
-    }
-    SequenceI [] getVisibleAndRepresentedSeqs()
-    {
-      if(hiddenSequences==null || hiddenSequences.getSize()<1)
-        return getSequencesArray();
-
-      Vector seqs = new Vector();
-      SequenceI seq;
-      SequenceGroup hidden;
-      for (int i = 0; i < sequences.size(); i++)
+      else
       {
-        seq = (SequenceI) sequences.elementAt(i);
-        seqs.addElement(seq);
-        hidden = seq.getHiddenSequences();
-        if(hidden!=null)
-        {
-          for(int j=0; j<hidden.getSize(false); j++)
-          {
-            seqs.addElement(hidden.getSequenceAt(j));
-          }
-        }
+        i++;
       }
-      SequenceI [] result = new SequenceI[seqs.size()];
-      for(int i=0; i<seqs.size(); i++)
-        result[i] = (SequenceI)seqs.elementAt(i);
-
-      return result;
-
     }
-
-  public CigarArray getCompactAlignment()
-  {
-    SeqCigar alseqs[] = new SeqCigar[sequences.size()];
-    for (int i=0; i<sequences.size(); i++) {
-      alseqs[i] = new SeqCigar((SequenceI) sequences.get(i));
-    }
-    return new CigarArray(alseqs);
+    return removed;
   }
-
 }