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+#  Sample dna matrix
+   A  C  G  T  U  R  Y  M  W  S  K  D  H  V  B  N  X 
+A  5 -4 -4 -4 -4  2 -1  2  2 -1 -1  1  1  1 -2 -1 -1
+C -4  5 -4 -4 -4 -1  2  2 -1  2 -1 -2  1  1  1 -1 -1
+G -4 -4  5 -4 -4  2 -1 -1 -1  2  2  1 -2  1  1 -1 -1
+T -4 -4 -4  5  5 -1  2 -1  2 -1  2  1  1 -2  1 -1 -1
+U -4 -4 -4  5  5 -1  2 -1  2 -1  2  1  1 -2  1 -1 -1
+R  2 -1  2 -1 -1  2 -2 -1  1  1  1  1 -1  1 -1 -1 -1
+Y -1  2 -1  2  2 -2  2 -1  1  1  1 -1  1 -1  1 -1 -1
+M  2  2 -1 -1 -1 -1 -1  2  1  1 -1 -1  1  1 -1 -1 -1
+W  2 -1 -1  2  2  1  1  1  2 -1  1  1  1 -1 -1 -1 -1
+S -1  2  2 -1 -1  1  1  1 -1  2  1 -1 -1  1  1 -1 -1
+K -1 -1  2  2  2  1  1 -1  1  1  2  1 -1 -1  1 -1 -1
+D  1 -2  1  1  1  1 -1 -1  1 -1  1  1 -1 -1 -1 -1 -1
+H  1  1 -2  1  1 -1  1  1  1 -1 -1 -1  1 -1 -1 -1 -1
+V  1  1  1 -2 -2  1 -1  1 -1  1 -1 -1 -1  1 -1 -1 -1
+B -2  1  1  1  1 -1  1 -1 -1  1  1 -1 -1 -1  1 -1 -1
+N -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1
+X -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1 -1