From 314897063b90dfa95740e500d6c4b1418fbf9f0d Mon Sep 17 00:00:00 2001 From: "cmzmasek@gmail.com" Date: Fri, 22 Aug 2014 22:44:02 +0000 Subject: [PATCH] in progress --- forester/aptx/aptx_example_files/wnt_seed_seqs.xml | 5708 ++++++++++++++++++++ 1 file changed, 5708 insertions(+) create mode 100644 forester/aptx/aptx_example_files/wnt_seed_seqs.xml diff --git a/forester/aptx/aptx_example_files/wnt_seed_seqs.xml b/forester/aptx/aptx_example_files/wnt_seed_seqs.xml new file mode 100644 index 0000000..68fc71c --- /dev/null +++ b/forester/aptx/aptx_example_files/wnt_seed_seqs.xml @@ -0,0 +1,5708 @@ + + + + + + 33208 + Metazoa + kingdom + + + 0.012195 + 99 + + 0.00662 + 28 + + 0.00344 + 6 + + 0.0022 + 1 + + 0.00148 + 0 + + 0.00396 + 5 + + 0.00258 + 15 + + 0.01323 + 61 + + 0.00504 + 46 + + 0.01441 + 65 + + 0.02347 + 100 + + 0.01855 + 94 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.01429 + 50 + + 20 + 71 + 142 + + + 0.00777 + 57 + + 20 + 71 + 142 + + + WNT2_EULMM/40-349 + 0.06843 + + 20 + 71 + 142 + + + 30603 + EULMM + Eulemur macaco macaco + Black lemur + subspecies + + + Q2IBG1 + Protein Wnt-2 + WNT2 + MCDNVPGLV---SRQRQLCHRHPD--------VMRAISLGVSEWTAECQHQFRQHRWNCNTLDRD--------------------------------HSLFGR-VLLRS--SRESAFVYAISSAGVVFAITRACSQGEL-KSCSCDPKK--------------------KGTAKDSKG-------------------------------------------------------------------TFDWGGCSDNI-DYGIKFARAFVDAKE-------RKGKDARAL--MNLHNNRAGRKAVKRFLKQECKCH---GVSGSCTLRT--------------------CWL-AMADFRKTGAYLWRKYNG-AIQVVMNQDGTGFTVA----------------------------------------------------------------------------------------------NKRFK----KP----------TKNDLVYFENSPDYCIRDREA-GSLGTAGRVC-------------NLT-SR---------GMDS-CEVMC--CGRGYDTSRVTRMT-KCECK-FH-----WCCAVRCQDCLEALDVHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q4SSA4_TETNG/11-320 + 0.06553 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4SSA4 + Protein Wnt + ICDNIPGLV---NKQRQLCQGHPD--------LMRSIGEGAKEWIKECQHQFRHHRWNCSTLDRD--------------------------------HTVFGR-VMLRS--SREAAFVYAISSAGVVYAITRACSQGEL-KSCNCDGQK--------------------RGRSSDATG-------------------------------------------------------------------SFDWGGCSDNI-NYGIKFAKAFVDARE-------KMMKDARAL--MNLHNNRCGRMAVKRFMKLECKCH---GVSGSCSLRT--------------------CWL-AMSDFRRTGDYLRKKYNS-AVEVTMNQDGTGFLVA----------------------------------------------------------------------------------------------DKNFK----GN----------TKNELVYVENSPDYCLMDRSA-GSLGTAGRVC-------------NKS-SR---------GTDG-CEIMC--CGRGYDTMRVKRVT-KCECK-FK-----WCCAVECSDCEDIVDVHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q8UW39_TAKRU/38-347 + 0.08277 + + 20 + 71 + 142 + + + 31033 + TAKRU + Takifugu rubripes + Japanese pufferfish + Fugu rubripes + species + + + Q8UW39 + Protein Wnt + WNT2 + MCDNIPGLV---NKQRQLCRQHPK--------VMQAIGSGIKDWISECQHQFRNHRWNCNTTARD--------------------------------HNLFGR-LLLRS--SREVAFIYALSSAGVVYALARACSQGDL-DSCSCDPAK--------------------KGSSRDAKG-------------------------------------------------------------------SFSWGGCSDHV-DHAMRFSQAFVDAKE-------RKERDARAL--MNLHNNRAGRKAVKRFMTLECKCH---GVSGSCSVRT--------------------CWS-AMADFRRTGDHLRKKYNG-AVQVAVNQYGTGFTTA----------------------------------------------------------------------------------------------HAHFK----QP----------GKNDLVYLEDSPDYCVRDQDS-GSLGTGGRLC-------------NRT-SP---------GTDG-CEVMC--CGRGYDTSRVGRTT-KCECK-FH-----WCCAVLCRDCHQQVDVHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 7472 + tru:100137508 + + + + + + WNT2B_MOUSE/69-378 + 0.0898 + + 20 + 71 + 142 + + + 10090 + MOUSE + Mus musculus + Mouse + species + + + O70283 + Protein Wnt-2b + Wnt2b + ICDNIPGLV---SRQRQLCQRYPD--------IMRSVGEGAREWIRECQHQFRHHRWNCTTLDRD---------------------------------HTVFGRAMLRS--SREAAFVYAISSAGVVHAITRACSQGEL-SVCSCDPYT--------------------RGRHHDQRG-------------------------------------------------------------------DFDWGGCSDNI-HYGVRFAKAFVDAKE-------KRLKDARAL--MNLHNNRCGRTAVRRFLKLECKCH---GVSGSCTLRT--------------------CWR-ALSDFRRTGDYLRRRYDG-AVQVTATQDGANFTAA----------------------------------------------------------------------------------------------RQGYR----HA----------TRTDLVYFDNSPDYCVLDKAA-GSLGTAGRVC-------------SKT-SK---------GTDG-CEIMC--CGRGYDTTRVTRVT-QCECK-FH-----WCCAVRCKECRNTVDVHTCK + + chondrocyte differentiation + + + receptor binding + + + frizzled binding + + + protein binding + + + proteinaceous extracellular matrix + + + extracellular space + + + signal transduction + + + cell-cell signaling + + + male gonad development + + + cellular response to starvation + + + organ morphogenesis + + + forebrain regionalization + + + neuron differentiation + + + canonical Wnt signaling pathway + + + lung induction + + + mesenchymal-epithelial cell signaling + + + hematopoietic stem cell proliferation + + + positive regulation of branching involved in ureteric bud morphogenesis + + + positive regulation of canonical Wnt signaling pathway + + + 7482 + mmu:22414 + 302825 + + + + + + A2SVS5_9MOLL/42-350 + 0.10471 + + 255 + 122 + 142 + + + 6613 + 9MOLL + Euprymna scolopes + phylum + + + A2SVS5 + Protein Wnt + MCSNIPGLV---GKQKRLCRVHQD--------VMISLRDGVQLGVKECQFQLRSQRWNCSTLDRD--------------------------------ASVFGK-VMLRG--SREAAFVYAISSAAVVHAITRACSKGIL-RNCSCDPSK--------------------IGKGRDKKG-------------------------------------------------------------------HFEWGGCSDNV-QYGSDFSRTFIDARE-------KKVRDARAL--MNLHNNRAGRRAVKRFLKLECRCH---GVSGSCSIRT--------------------CWS-AMMEFRRVGDYLKNKYNG-AVQVMMNQEGTGLIVA----------------------------------------------------------------------------------------------NKDHK----RP----------TRSDL-YFEASPDYCMRNLEI-GSLGTSGRQC-------------NKT-SL---------GTDG-CDIMC--CGRGYDTETVKQTR-KCQCK-FH-----WCCQVKCKECVEYVDVHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q75PH4_PARTP/59-367 + 0.15068 + + 0 + 173 + 193 + + + 114398 + PARTP + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH4 + Protein Wnt + wnt2 + LCGGIPGLA---RKQREICEQHPD--------ILLSVTKGARIGVSECQAQFRNQRWNCSTLGSG--------------------------------ASVFGSHMLKVD--SRESAFLYAISSAGVTHAIIRSCSRGEI-PNCPCDPLR--------------------RGFGFDPTV------------------------------------------------------------------GGYSWGGCS-HI-SAGVKFARQFIDARE-------DRRKDARAL--MNFHNNRAGRKAVQKKTRLQCKCH---GVSGSCASRT--------------------CWS-AQMEFREVGRLLKRKYEG-AVQVTMSNQMALVS------------------------------------------------------------------------------------------------VDGTK----PY----------TKLDLIYFESSPDFCAINKSL-GTLGTGGRRC-------------DRD-SK---------GVEG-CAILC--CGKGYDTRRELFAE-KCSCK-FN-----WCCKVKCKVCREWKDVYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q5IHW2_NEMVE/41-346 + 0.14196 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IHW2 + Protein Wnt + Wnt2 + MCNSITGLI---SIQRQMCLDNPD--------VMVSIGKGAKLGVEECQHQFRDQRWNCSTVNGD--------------------------------ATVFGK-VMRRA--SRETAFVYAISSAGVVHEVTRSCSLGEL-KDCSCRNK---------------------KGRSRKG----------------------------------------------------------------------FEWGGCSDNI-QYGLNFAKAFVDSRE--------VEKDARAL--MNLHNNHVGRRVVKTNMSLDCKCH---GVSGSCSVRT--------------------CWK-SISSFRIVGQHLREKYTT-AVQVTVGQSGGELTNA----------------------------------------------------------------------------------------------EVSYK----KP----------SRDDLVYLEDSPNYCMVDSNT-GSLGTSGREC-------------NGS-AS---------DTTGACSLLC--CGRGFNTIQIEEEY-KCHCK-FH-----WCCYVKCQTCRRTVDKHICK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q4H308_CIOIN/51-362 + 0.18192 + + 20 + 71 + 142 + + + 7719 + CIOIN + Ciona intestinalis + Transparent sea squirt + Ascidia intestinalis + species + + + Q4H308 + Protein Wnt + Ci-Orphan Wnt b + ICLQMPLEP----EQKQYCKNHTK--------IMERIRDGTEMAMKECQYQFRNERWNCSSADES---------------------------------QGFGK-VLKRG--TREAAFVGAITSAAVAHEVTRACSRGEL-TECSCDGQK--------------------RMGSYRDHR------------------------------------------------------------------GRFEWAGCSDDV-QFGMSVAKIFVNTKD-------NALHDARAI--MNVHNNRAGRKTVKSFMKRFCKCH---GATDTCPLRT--------------------CWD-ALDSFRLSGNQLKRKYDG-ASRVTVKQGSRKMTLHTT--------------------------------------------------------------------------------------------VSSHK----SP----------TKRDLVYLEDSPNYCVRNEAT-GSLGTSGREC-------------NLS-SK---------GIDG-CSLLC--CGRGHDTSSVTRTRINCACV-FH-----WCCEVRCTNCTNTYDIYTCK + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + cin:778720 + + + + + + 0.03087 + 95 + + 0.00931 + 76 + + 0.05457 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.02373 + 90 + + 20 + 71 + 142 + + + A5WVL3_DANRE/45-356 + 0.085 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + A5WVL3 + Protein Wnt + wnt16 + GCAHLPLSH----KQKELCARKPH--------LLPSVKEGARLGITECQTQFRHERWNCSTRRDP---------------------------------NVFGY-ELTSG--TKETAFIHAVMAAGLVHAVTRSCSAGNM-TECSCDTSL--------------------LGSGSPTE--------------------------------------------------------------------GWHWGGCSDDI-AFGTSFSRRFIDSAAK-----NTSTRGEEALLIMKQHNSEAGRQAVAKTMLTDCRCH---GVSGSCAVKT--------------------CWR-TMAAFERVGAYLKDRYET-SVHVVDRSKRKVRRKD----------------------------------------------------------------------------------------------KEQRH----VP---------ITKDELIFFNKSPNYCLEDRRL-GVTGTRGRKC-------------NRT-SA---------GPDG-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCETMNDMHTCK + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Notch signaling pathway + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + canonical Wnt signaling pathway + + + hematopoietic stem cell differentiation + + + 51384 + dre:791563 + 20930679 + + + + + A4ZGN9_XENTR/45-376 + 0.13469 + + 20 + 71 + 142 + + + 8364 + XENTR + Xenopus tropicalis + Western clawed frog + Silurana tropicalis + species + + + A4ZGN9 + Protein Wnt + wnt16 + GCTNLPLSF----HQKEMCRKKPY--------LLSSIREGARLGIHECRNQFKHERWNCSVSPTISSASSSFSLS-------------FITSSLASAHTIFGY-ELSSG--TKETAFISAVTAAGLVHSVTRACSAGNM-TECSCDTSL--------------------QNGGSASE--------------------------------------------------------------------GWHWGGCSDDL-QYGMWFSRKFLDAPYK-----NSSGRDSDVLNAMHLHNNEAGRQAVTKLMTVDCRCH---GVSGSCAVKT--------------------CWK-SMSSFEKIGNFLKNKYEN-SIQIADRLKRKVRRRE----------------------------------------------------------------------------------------------KNDRK----IP---------IYKGDLVYTNKSPNYCVEDPKL-GISGTHGREC-------------NRT-SE---------GSDS-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCESMTDVHTCK + + proteinaceous extracellular matrix + + + Notch signaling pathway + + + Wnt signaling pathway + + + hematopoietic stem cell differentiation + + + 51384 + xtr:100125197 + + + + + + Q4T8H0_TETNG/14-319 + 0.11715 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4T8H0 + Protein Wnt + NCSHVPLSP----RQRSLCQKKSF--------LLPSIQDGARLAVSECQNQFRHERWNCSTSQTP---------------------------------SVFGQ-ELTSG--TKETAFIYAVMAAGLVHAVTLFCSHGNR-TECACEGRG--------------------RGLAEER----------------------------------------------------------------------WHWGGCSEHV-RYGTWFSRRFMDGGRN------ASSGGGFTLAAMNQHNGEVGRQAVHRLMPTHCRCH---GVSGSCAAKT--------------------CWK-TTAAFERVGVYLKERYER-SVQVTSPSRKRAR-------------------------------------------------------------------------------------------------KAGLR----PP---------VDGQQLVFIHKSPNYCVEDRRR-GVAGTRGRRC-------------SRS-SG---------GADG-CNLLC--CGRGYNTHVVRHVQ-RCDCK-FV-----WCCYVRCRRCERMNDTHTCK + + proteinaceous extracellular matrix + + + Notch signaling pathway + + + Wnt signaling pathway + + + hematopoietic stem cell differentiation + + + + + + Q75PH5_PARTP/46-355 + 0.13426 + + 0 + 173 + 193 + + + 114398 + PARTP + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH5 + Protein Wnt + wnt16-like + MCSSVPGLV---MQQQKVCQAHPA--------VIKAVSSGAKRGIHECQNQFRHDRWNCTIEGGE---------------------------------SVFDH-TLQRG--SRETAFIYAITSAGATHAVTQACSAGNL-TDCSCDTSR--------------------QGQSMPEG---------------------------------------------------------------------WKWGGCSDNV-RYGMMFARQFVDAPER-----AERKRDVRAL--MNLHNNNAGRLAIARQMELKCRCH---GVSGSCELKT--------------------CWN-KLPSFEQVGHFLKSKYDN-SIQVSLKAKRRLRRRG----------------------------------------------------------------------------------------------KVKRK----VP---------VQKEDLVHIHRSPNYCIEDFKR-GILGTSGRRC-------------NRT-AK---------GPQS-CNLLC--CGRGYNTQVHRRLE-RCQCK-FH-----WCCYVKCKTCETMEEIYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A7S694_NEMVE/17-329 + 0.16188 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + A7S694 + Protein Wnt + SCSRVPGLS---LQQLRMCLQKPD--------VIPSVSQGANIGIHECKKQFKYERWNCSTSNDP---------------------------------TVFGT-LLKIA--HKESAFVYAITSAGVVHAVGKSCSKGNL-TECSCESKR--------------------GARNQPKG---------------------------------------------------------------------WEWGGCSDNV-NYGVWLSKTFVDAPEKAD-RRARSQRKARAM--MNLHNNEAGREAVLALMRVQCRCH---GVSSSCAVKT--------------------CSK-SLPKFEEVGEALKAEYKD-AIRAVYIKRKRKLKRKD---------------------------------------------------------------------------------------------NKKLR----IP-----------SSSLVYLDESPNYCYRDKKL-GIDGTSGREC-------------NKN-SS---------GVDG-CDLLC--CGSGYNTQTVRSVH-SCHCR-FI-----WCCNVVCKKCEKIFDRYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + 0.00881 + 38 + + 0.02064 + 70 + + 0.00813 + 66 + + 0.01218 + 68 + + 0.02329 + 96 + + 20 + 71 + 142 + + + 7711 + Chordata + phylum + + + 0.02432 + 99 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.01427 + 72 + + 20 + 71 + 142 + + + WNT7B_CHICK/37-349 + 0.05239 + + 20 + 71 + 142 + + + 9031 + CHICK + Gallus gallus + Chicken + species + + + Q3L254 + Protein Wnt-7b + WNT7B + ICNKIPGLA---PRQRAICQSRPD--------AIIVIGEGAQMGINECQYQFRYGRWNCSALGEK---------------------------------TVFGQ-ELRVG--SREAAFTYAITAAGVAHAVTAACSQGNL-SNCGCDREK--------------------QGYYNQEE--------------------------------------------------------------------GWKWGGCSADI-RYGIEFSRRFVDARE--------IKKNARRL--MNLHNNEAGRKVLEERMKLECKCH---GVSGSCTTKT--------------------CWT-TLPKFREIGYILKEKYNA-AVQVEVVRASRLRQPTFL-----------------------------------------------------------------------K--------------------IKQIKS-YQKP----------METDLVYIEKSPNYCEEDAST-GSVGTQGRLC-------------NRT-SP---------NADG-CDMMC--CGRGYNTHQYTKVW-QCNCK-FH-----WCCFVKCNTCSERTEVFTCK + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + positive regulation of JNK cascade + + + lens fiber cell development + + + 7477 + gga:427937 + 20829062 + + + + + Q4STC2_TETNG/13-326 + 0.07007 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4STC2 + Protein Wnt + ICNKIPGLA---PRQRALCQSRPD--------AIIIIGEGAQLGINECQFQFRYSRWNCSTLGER---------------------------------TVFGQ-ELRVG--NREAAFTYAVVAAGVAHAVTKACSQGHL-SQCGCDHEK--------------------QGFHHYHQE-------------------------------------------------------------------GWKWGGCSANV-RYGVEFSRRFVDARE--------IKKNARRL--MNLHNNAAGRKILEERMKLECKCH---GVSGSCTTRT--------------------CWV-TLPKFREIGRLLKERYSA-AVQVEPVRASRLRQPSFL--------------------------------------------------------------------------------------------RLKGARGYQKP----------ADTDLVYLERSPSYCKEDAAT-GSTGTRGRRC-------------DSN-ST---------LTDG-CGAMC--CGRGFDAHRYTRIW-QCNCK-FH-----WCCFVQCSTCSEKSEVFTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q4RJT5_TETNG/37-350 + 0.07948 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4RJT5 + Protein Wnt + WNT7A + ICNKIPGLA---PRQRIICQSRPD--------AIIVIGEGAQMGINECQFQFRNWRWNCSALGER---------------------------------TVFGK-ELKVG--SKEAAFTYAIIAAGVAHAITAACTQGNL-GDCSCDKEK--------------------QGFYSIDQ--------------------------------------------------------------------GWKWGGCSADI-SYGLGFSKVFIDARE--------VKQNARTL--MNLHNNEVGRKVLEKSMQLECKCH---GVSGSCTTKT--------------------CWT-TLPKFRELGYILKEKYVH-AVHVEPVKASRNKRPKFL--------------------------------------------------------------------------------------------KVKKPYSYRKP----------MDTDLVYIDKSPNYCEVDHLT-GSLGTHGRVC-------------NKTMMQ---------HISG-CDLMC--CGRGYNTHQYSRVW-QCNCK-FL-----WCCYVKCNTCSERTEVYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + O61700_BRAFL/35-347 + 0.1 + + 20 + 71 + 142 + + + 7739 + BRAFL + Branchiostoma floridae + Florida lancelet + Amphioxus + species + + + O61700 + Protein Wnt + Wnt7b + ICNRIPGLV---PRQRAICQTRPD--------LIVAIGEGAQRGIDECRYQFRHSRWNCTGMDND---------------------------------NVFGR-ELRIG--SKEAAFTYAISSAALVHAIVTACSQGNI-SDCGCDRTK--------------------EGDLNDEG---------------------------------------------------------------------WKWGGCSADV-KYGLRFCKKFVDARE--------VEQNARAL--MNLHNNEAGRKVIDQHTRLECKCH---GVSGSCTMKT--------------------CWI-TLPRFREVGNILKEKYHHDAQLVEAVRARRTRRPTFL--------------------------------------------------------------------------------------------KLKNSRTFEKP----------REISLVYLRGSPNYCERDEAT-GSLGTHGRRC-------------NRT-SP---------YQDG-CDLMC--CGRGYNTHQFVKTW-QCNCK-FH-----WCCYVKCNQCSERTEEYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 7215283 + + + + + + 0.00853 + 62 + + 0.02382 + 100 + + 0 + 173 + 193 + + + 114398 + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH6_PARTP/41-360 + 0.10628 + + 0 + 173 + 193 + + + 114398 + PARTP + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH6 + Protein Wnt + wnt7-2 + ICSKIPGLT---PAQQRLCQERPD--------LIVAVGDGARMGINECQKRFRHRRWNCTAIGSS---------------------------------YVFGH-VVVIG--SREAAYTYAVTSAGVTYAITQACSRGTL-WHCGCDISK--------------------DGMLDPEG--------------------------------------------------------------------GWKWGGCSADV-RHGMKMSRQFMDARE--------IEGDERSL--MNLHNNRAGRKAVLFTVQTECKCH---GVSGSCTMKT--------------------CWL-TLPPFSKTGDYLMRRYQI-AKRVFAHFGGPAKKTTRKTR-------------------------------------------------------------------PLF-L-----------------RTKKSKRPHRKP----------RPRDLVYLEKSPNYCEADPMK-GSTGTSGRLC-------------NRT-SR---------GTDG-CDLLC--CGRGYNTHQFTRTA-QCRCK-FH-----WCCYVDCRVCTERTEVYSCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q75PH8_PARTP/42-358 + 0.10483 + + 0 + 173 + 193 + + + 114398 + PARTP + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH8 + Protein Wnt + wnt7-1 + ICNKIPGLT---MPQRIFCQTRPD--------IVVAIGEGTRLGVAECQRQFRYHRWNCSTIGSN---------------------------------QVFGH-VIVVG--SREAAYMYSVTSAGVTFVITQSCSRGNV-SDCGCDKSQS-----------------SVKPLNHPTD---------------------------------------------------------------------WKWGGCSVDV-KYGIRLSRKFIDARE--------MEGDARSL--MNLHNNHAGRKAVKHNLKTECKCH---GVSGSCTMKT--------------------CWK-TLPAFAQIGDYLMKAYKQ-SKKVVPHWGPMVTRTPSH-----------------------------------------------------------------------L-------------------KLKKSKRVHRKP----------RPRDLVYLENSPNYCEKDLSR-GSLGTVGREC-------------NRT-SK---------DIDG-CDLLC--CGRGYNTHQYIRTW-QCNCK-FH-----WCCYVNCDVCRERTENYVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A2SVS9_9MOLL/38-351 + 0.12678 + + 255 + 122 + 142 + + + 6613 + 9MOLL + Euprymna scolopes + phylum + + + A2SVS9 + Protein Wnt + ICNKIPDLV---PKQRSICQRRPD--------AIVVVGEGVKLGIQECRYQFRNMRWNCTHTRSR--------------------------------NSMFAH-VHLVP--NREAAFSFAIVSAGIAYAITQACSRGNL-SRCGCDKSK--------------------LPNYSHNG---------------------------------------------------------------------WKWGGCSADV-KYGLSFARNFVDIRE--------ITKNARAL--MNLHNNRAGRKAVKDNMVTECKCH---GVSGSCTMKT--------------------CWT-TLRPFRMIGNHLMRKYQT-AKITRVIRGSRTLRPIFL-------------------------------------------------------------------------------------------ILKKSKRQNRKP----------RRSDLVCLEKSPNYCDRDERT-GALGTVGRKC-------------LRE-SK---------QTIG-CDLMC--CGRGYNTHQYTVTV-QCACK-FY-----WCCYVRCEKCSNKTEEYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + 0.02882 + 96 + + 0 + 173 + 193 + + + 7147 + Diptera + order + + + 0.0487 + 100 + + 0 + 173 + 193 + + + 7157 + Culicidae + mosquitos + family + + + Q16Z87_AEDAE/21-350 + 0.11655 + + 0 + 173 + 193 + + + 7159 + AEDAE + Aedes aegypti + Yellowfever mosquito + Culex aegypti + species + + + Q16Z87 + Protein Wnt + LCSRIPGLS---PYQRQLCVEAPD--------AVVSLSTGQKLGAQECQHQFRGHRWNCTQVWKK---------------------------------DMFGH-IVIIG--SREAAFTYGITSAGAVHAITAACAKGNI-TMCGCDSKQ--------------------KMQFSTESD-------------------------------------------------------------------SWKWGGCSADI-GFGMRFTKKFLDARE--------IENDDRSL--MNLHNNRVGRKIVKLLLRTECKCH---GVSGSCAMKT--------------------CWK-SLPPFHAIGDIMMKKYRK-AKMVQATPVVMAMTSTGKINNGQL------------------------------------------------------------QLVLRR-RG---------------KLMQHTSVNSQKP----------KRMELVYLQHSPNYCDRDIAS-GILGTVGRQC-------------NRT-ST---------SMDK-CDLLC--CGRGYNTHQIVKSW-QCNCN-FK-----WCCTVNCDICTERTEEYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + A0NG52_ANOGA/28-354 + 0.19457 + + 0 + 173 + 193 + + + 7165 + ANOGA + Anopheles gambiae + African malaria mosquito + species + + + A0NG52 + Protein Wnt + LCSRMPGLT---QTQRQICTESSD--------AVVSLASGQWIGASECQKQFHGHRWNCTHVWNT---------------------------------DMFGQ-IVVIG--SREAAYTYAITSAGAVYSITTACAKGNI-TTCGCDMNQ--------------------KIFSSSESE-------------------------------------------------------------------NWKWGGCSVDI-GYGMRFAKKFLDARE--------IENDNRSL--MNMHNNRVGRKPDSILDHTEAG-----NLSWTPHIFTNFSPISLRYPEQFYRPVILNIFA-AFPPYK-----VHVRFHS-PLTISLKGCVKVNNPLLK--------------------------------------------------------------------------------------------NGKTLGDSQIP----------KRTELVYLEPSPNYCERNISI-GVLGTADRNC-------------NRT-SQ---------SIDH-CDLLC--CGRGYNTHQIERTW-QCNCK-FK-----WCCTVTCDVCSERKEAYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + WNT2_DROME/29-352 + 0.14749 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + P28465 + Protein Wnt-2 + Wnt2 + LCGRIPGLT---PGQRNMCREMPD--------ALIALGEGHQLGAQECQHQFRGHRWNCSEVWQR---------------------------------NVFAH-VIPTA--SREAAYTYAIASAGAAYAVTAACARGNI-STCGCDVRH--------------------KATPTGGGTP----------------------------------------------------------------DEPWKWGGCSADV-DFGMRYARRFMDARE--------LERDSRTL--MNLHNNRAGRTLVKKMLRTDCKCH---GVSGSCVMKT--------------------CWK-SLPPFRLVGDRLMLKYQK-AKTVQAVKGKRGLRLVLSRK-------------------------------------------------------------------KHA-G-----------------TARAQKPVLDWP----------KRMELIYLEASPNYCERSLQT-GSQGTSGRTC-------------QRT-GH---------GPQS-CDLLC--CGRGHNTQHIRRTT-QCRCQ-FR-----WCCEVKCDECDESYEEFTCK + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + segment polarity determination + + + open tracheal system development + + + muscle organ development + + + Wnt signaling pathway + + + cell fate commitment + + + axon extension + + + 7472 + 796130 + + + + + + + Q966W2_HALRO/104-436 + 0.22451 + + 20 + 71 + 142 + + + 7729 + HALRO + Halocynthia roretzi + Sea squirt + Cynthia roretzi + species + + + Q966W2 + Protein Wnt + HrWnt-7 + ICNKIPGLS---PQQRIRCQSRPD--------AIVAVNEGAHKGLQECQRQFRHHKWNCSTQKER---------------------------------SIFGD-DQKLA--TKEAAIHNAIRAAGVLHAIVTACGEGNL-RDCGCDKSL--------------------RGYFPDESKSKWRRQNIML-----------------------------------------------EMSRRSMSLQTWKWGGCSIDL-KHGIQYSKDFWDSRE--------MRRDARGL--MNLHNYEAGRYAVENNVKLECKCH---GVSASCTTKT--------------------CWL-TLPDFRKVGDTLKKSYER-SRRVTVQTGRIRPMYLI---------------------------------------------------------------------------------------------NLEKRGRSNKP----------RKHDLVYLVPSPEYCENDVIS-ETQGTVGRTC-------------NKT-ST---------GVNS-CDNMC--CGRGYRTHHRVHKW-DCKCK-FF-----WCCHVKCKQCRENVEQYTCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.13752 + 100 + + 20 + 132 + 81 + + + 45351 + Nematostella vectensis + Starlet sea anemone + species + + + Q49N21_NEMVE/28-331 + 0.0897 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q49N21 + Protein Wnt + ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVVNRSLLTECTCH---GPSASCVTRT--------------------CSQ-ALPSPRAVSNRLKALYDT-ARRATVYLSSLVRPDDKVE----------------------------------------------------------------------K-------------------V---------------------KPMDLAYLKDSPNYCTKNTLS-KLPGTLGGNC-------------KISDDS---------QEEENCDVMC--CGRGYDTHLITKRW-QCRCK-FV-----WCCNVRCSTCSKRDIVQTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q5IHV9_NEMVE/42-359 + 0.09414 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IHV9 + Protein Wnt + Wnt7b + ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVIRNNLDLSCKCH---GPSGSCNTKT--------------------CWK-SVPSFRMVGEKLRALYESRQATVKVVAAMKTSKGGQVP---------------------------------------------------------------------AY-I-----------------VVKGTNKVVKPN----------SSANLVYLDNSPSYCNKIKSL-KVPGTVGRVC-------------SRTPES---------AEDVSCEVMC--CGRGYSVREQIKEW-KCHCK-FH-----WCCRVECAKCSKKLMVHTCQ + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + + 0.00446 + 6 + + 0.00713 + 26 + + 0.01288 + 37 + + 0.01922 + 62 + + 0.06626 + 100 + + 0.04451 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.01499 + 67 + + 20 + 71 + 142 + + + 0.0197 + 85 + + 20 + 71 + 142 + + + Q90YJ8_DANRE/18-337 + 0.0744 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + Q90YJ8 + Protein Wnt + wnt8a + ILGHTW-------TMNNLLITGPKAY----LTYANSVRVGAQSGIHECKHQFAWDRWNCPDTA-L---------------------------------QLSTHKGLRSA--TRESSFVHAISAAGVMYTLTRNCSLGDL-NECGCDSSR--------------------NGRLGGRG---------------------------------------------------------------------WLWGGCSDNV-DFGERISKQFVDALE--------TGQDARAA--VNLHNNEAGRLAVKATMKRICRCH---GMSESCTMQT--------------------CWM-QLADFREIGNYLKVKHDQ-AQKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------NRVTMTDAFGSI----------ARTELIYLEDSPDYCAKNLSL-GLPGTEGREC-------------VQHGESLS-----QWERRS-CRRLCHECGLRVEERRTEVVS-SCNCK-FH-----WCCTVKCENCSQVTVKHVCT + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 20880563 + + + + + Q564K5_CHICK/19-338 + 0.06733 + + 20 + 71 + 142 + + + 9031 + CHICK + Gallus gallus + Chicken + species + + + Q564K5 + Protein Wnt + Wnt8c + LNAAAW-------SVNNFLMTGPKAY----LTYSSSVAAGAQSGMEECKFQFGWERWNCPESA-L---------------------------------QLSTHNRLRSA--TRETSFVHAISSAGVMYTLTRNCSLGDF-ESCGCDDSR--------------------NGRVGGRG---------------------------------------------------------------------WVWGGCSDNV-EFGERISKLFVDALE--------TGHDTRAL--INLHNNEVGRLAVKATMKRACKCH---GVSGSCSIQT--------------------CWL-QLADFREIGNYLKMKYDQ-AHKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------SRGATAETFHHV----------HSTELVFLEDSPDYCTRNASL-GHHGTEGREC-------------LQTGKNLS-----QWERRS-CRRLCTECGLKVEERRTEVVS-SCNCK-FH-----WCCTVRCEQCRQLVAKHFCA + + cell morphogenesis + + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + endoderm development + + + polarity specification of anterior/posterior axis + + + polarity specification of proximal/distal axis + + + neuron differentiation + + + regulation of protein localization + + + embryonic hindlimb morphogenesis + + + cell fate commitment + + + positive regulation of fibroblast growth factor receptor signaling pathway + + + establishment of organ orientation + + + palate development + + + regulation of canonical Wnt signaling pathway + + + canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment + + + + + + Q0VBT1_MOUSE/18-337 + 0.10083 + + 20 + 71 + 142 + + + 10090 + MOUSE + Mus musculus + Mouse + species + + + Q0VBT1 + Protein Wnt + Wnt8a + LGASAW-------SVNNFLITGPKAY----LTYTASVALGAQIGIEECKFQFAWERWNCPEHA-F---------------------------------QFSTHNRLRAA--TRETSFIHAIRSAAIMYAVTKNCSMGDL-ENCGCDESQ--------------------NGKTGGHG---------------------------------------------------------------------WIWGGCSDNV-EFGEKISRLFVDSLE--------KGKDARAL--VNLHNNRAGRLAVRASTKRTCKCH---GISGSCSIQT--------------------CWL-QLADFRQMGNYLKAKYDR-ALKIEMDKRQLRAGNRAE-------------------------------------------------------------------------------------------GRWALTEAFLPS----------TEAELIFLEGSPDYCNRNASL-SIQGTEGREC-------------LQNARSAS-----RREQRS-CGRLCTECGLQVEERRAEAVS-SCDCN-FQ-----WCCTVKCGQCRRVVSRYYCT + + cell morphogenesis + + + regionalization + + + frizzled binding + + + protein binding + + + proteinaceous extracellular matrix + + + extracellular space + + + endoderm development + + + polarity specification of anterior/posterior axis + + + polarity specification of proximal/distal axis + + + Wnt signaling pathway + + + neuron differentiation + + + regulation of protein localization + + + cell fate commitment + + + establishment of organ orientation + + + 7478 + mmu:20890 + 299745 + + + + + + WNT8B_HUMAN/15-334 + 0.0957 + + 20 + 71 + 142 + + + 9606 + HUMAN + Homo sapiens + Human + species + + + Q93098 + Protein Wnt-8b + WNT8B + CVLQLSHSW----SVNNFLMTGPKAY----LIYSSSVAAGAQSGIEECKYQFAWDRWNCPERA-L---------------------------------QLSSHGGLRSA--NRETAFVHAISSAGVMYTLTRNCSLGDF-DNCGCDDSR--------------------NGQLGGQG---------------------------------------------------------------------WLWGGCSDNV-GFGEAISKQFVDALE--------TGQDARAA--MNLHNNEAGRKAVKGTMKRTCKCH---GVSGSCTTQT--------------------CWL-QLPEFREVGAHLKEKYHA-ALKVDLLQG---AGNSAA-------------------------------------------------------------------------------------------GRGAIADTFRSI----------STRELVHLEDSPDYCLENKTL-GLLGTEGREC-------------LRRGRALG-----RWERRS-CRRLCGDCGLAVEERRAETVS-SCNCK-FH-----WCCAVRCEQCRRRVTKYFCS + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + signal transduction + + + gastrulation + + + nervous system development + + + positive regulation of gene expression + + + negative regulation of gene expression + + + Wnt signaling pathway + + + neuron differentiation + + + response to estradiol + + + response to retinoic acid + + + cell fate commitment + + + determination of dorsal identity + + + cellular response to retinoic acid + + + 7479 + hsa:7479 + 601396 + 29296 + PA37390 + + + + + + 0.00972 + 62 + + Q9U416_BRABE/27-337 + 0.14387 + + 20 + 71 + 142 + + + 7741 + BRABE + Branchiostoma belcheri + Amphioxus + species + + + Q9U416 + Protein Wnt + wnt8 + L-------------QNNILITGPKSSFQASLTYASSVAAGAQTAMEECKYQFSWDRWNCTDNA-L---------------------------------AMFKPNTLP-A--NRETSFVHAISAAGVMYVLTRNCSKGAF-EQCGCDVTN--------------------NGKKAEGG---------------------------------------------------------------------WTWGGCSDDI-AFGERISKMYSDGVE--------NGQDARAA--MNLHNNDVGRKAVRQTMKRVCKCH---GVSGSCTTKT--------------------CWL-QLADFRAIGVFLKKKYKK-ADKVDYVRGQLTENNSAS-------------------------------------------------------------------------------------------SKRNTG----------------LKKDMVFLEDSPDYCRENLTV-GSRGTLGREC-------------LRGGKNRD-----KYEKKS-CKRLCKDCGYVPKRITTEVTS-SCNCK-FH-----WCCSVKCSQCTKTVTKYICV + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q6QWF4_HELTB/9-337 + 0.21462 + + 40 + 20 + 71 + + + 7635 + HELTB + Heliocidaris tuberculata + Sea urchin + species + + + Q6QWF4 + Protein Wnt + S------------PASNVLLAGSKSKS--HVTYIDSVSAGIQNAVQECQYQFKWDKWNCPEA------------------------------------SVFTNT---QA--NREMSFVQAIASAGVMYSLTRNCSQGAF-EDCGCDERR--------------------NGDTGGEG---------------------------------------------------------------------WTWGGCSDNV-RFGERMASDIMDDSE--------KSQGAISV--MNLHNNEAGRKAVKQTLQRTCKCH---GVSGSCSLQT--------------------CWN-HVANFRVVGDEIKRKYFK-AVRVDFVSGKLIDGNRPE-------------------------------------------------------------------------------------------DRFPRAVMTASL----------NRRDLVFLDQSPDYCRANLTI-GITGTAGRECMVRQDVDDSSSSSSLT-KDMTSPSSFRWVKQS-CSRLCRSCGMEIRQTEVVITS-SCNCN-FV-----WCCQVKCDTCRRTVTRRTCQ + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + Q5IHV8_NEMVE/13-321 + 0.23494 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IHV8 + Protein Wnt + Wnt8b + VLKVLRGRE-----------AYDK--------LVSSIQKGAKLGLQECRSQFRNEKWNCTMAVKTKNKS------------------------TSKQNPAYVMSMVPHA--TREMAFAHGISAAGVTFALTMDCRLGAF-EDCSCIHGK--------------------SEGNKGN----------------------------------------------------------------------W-WGGCNENV-KFGEVMARHFLEALQ--------SGKDERSL--LNVHNNEVGRKAVRATLKRECRCH---GISGSCSTRT--------------------CWR-KLSSFAEVGQYLVEKYST-AKRVIFQNGNFYELTMLG-------------------------------------------------------------------------------------------TRPISK----------------KDNNFIYSESSPDYCQRNMTV-GSAGVLGREC-------------EGS-KD---------ELVR-CRQLCDSCRFDTQEFTEIKNT-FCNCK-FH-----WCCKVKCMTCKETTRKTRCV + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.00862 + 33 + + 0.02008 + 88 + + 0.02595 + 92 + + WNT8_DROME/15-309 + 0.3095 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + Q9VFX1 + Wnt inhibitor of Dorsal protein + wntD + LAAVLEPMSYYQYTQFQAPLSWED-----------ITGKGLKQALDSCQQSFQWQRWNCPSQD-F--------------------------------VQKNSKPEENSP--NREDVYVAAISMAAIVHTLTKDCANGVI-AGCGCTENA--------------------------------------------------------------------------------------------------LNVPCAHEPTKALEQYEKHFGSGSG------------------AIGHNRRVVGALLQRSLEQECRCKQPGAVQGECQEEE--------------------CVA-VLKPFEAIAQDLLQMYDD-AIQLEGASSNLKIMWQNI-----------------------------------------------------------------------------------------------------------------PLDSLVFMQDSPNYCERDATG-LWKGTRGRQC-------------SKD-GSG------SLEERLSCQQLCRVCGYRVRSQHVRTER-RCNCK-LV-----WGFRLQCDVCVQLERQYSCY + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + pole cell migration + + + ventral furrow formation + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + regulation of embryonic development + + + defense response to Gram-positive bacterium + + + 41633 + 824739 + 4KRR + + + + + Q675W2_OIKDI/28-306 + 0.27475 + + 20 + 71 + 142 + + + 34765 + OIKDI + Oikopleura dioica + Tunicate + species + + + Q675W2 + Protein Wnt + ICE-FEGLT---RPQKRLCQKYPK--------FQPALKAASLSTINLCKSSMKGHLWGCKGAD-K---------------------------------LPAIGPELSEA--TSESAFVHALGAGQLLAALKTICRTGAS-GSCDEDELR------------------------------------------------------------------------------------------------------------MFAIQFTDVLAMSRR------------AKGQKTVELHNNDVGRSTADRHSRLVCKCH---GQSGSCTQKT--------------------CWR-GSPDPEKVATELSTKYES-AAKVRAQDELPAIFRQYV-----------------------------------------------------------------------------------------------------------------VRDRLLYIKNSINHCEI---------TKGREC-------------NPY-SS---------EKSS-CERLC--CGRGFITRLHKEPRRECKMQTIEVDGSLWPAGITCKTVYDSSISHSCR + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 6166716 + + + + + + 0.12867 + 100 + + 132 + 40 + 122 + + + 119089 + Chromadorea + class + + + LIN44_CAEEL/62-339 + 0.12154 + + 132 + 40 + 122 + + + 6239 + CAEEL + Caenorhabditis elegans + species + + + Q27886 + Abnormal cell lineage protein 44 + lin-44 + ALR----------SIQLACRTHPA--------TVISAFEGVQEGLQNCANRLRFQQWDCSEAGN----------------------------------IMHDPPLLRQG--FRESSLIWALSSASAAWGVATACAQGWI-DDCACNNQM--------------------GQNE-------------------------------------------------------------------------YEFGGCTHGV-QHGITASRKLLTKVG--------AVNTLLRK--VEKHNLKAGRLAIKKTLISSCKCH---GVSGSCQQKT--------------------CWK-RTATLEHITDYLVEKYAR-AKLYTDDSVV-------------------------------------------------------------------------------------------------------------------------KTTDLIYLEASPDVC-------KAKSVAGRVC-------------AWRNET---------HTQGDCDRLC--CGNGFSIRHEVVRV-KCDCE-FV-----WCCNLVCKDCIQHRWISTCN + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + establishment or maintenance of cell polarity + + + Wnt signaling pathway + + + neuron differentiation + + + vulval development + + + regulation of vulval development + + + tail tip morphogenesis + + + regulation of oviposition + + + cell fate specification involved in pattern specification + + + 171994 + 873579 + + + + + Q5IWQ9_PRIPA/94-384 + 0.11121 + + 132 + 40 + 122 + + + 54126 + PRIPA + Pristionchus pacificus + Parasitic nematode + species + + + Q5IWQ9 + Protein Wnt + wnt + GCPNLLLLSRLFGHIRVECRTRPS--------TAIAAYEGIKDAMNECSSRMKFLPWDCSQTED----------------------------------IMHDPILLKYG--YKESALVWALSSAGSAWAVATACAQGWL-SDCECSKEM--------------------EEAGKH-----------------------------------------------------------------------WEWGGCSAGV-QHGITTSRKMLTRTS-------GGTNSALRK--LEKHNLKAGRLAVKKTLTSLCKCH---GVSGSCQQKT--------------------CWK-QPASMTTITKHLIEKYHK-AKVMTDEGKL-------------------------------------------------------------------------------------------------------------------------RNNDLLFLEASPDHC-------AVRGEKPRVC-------------GWRNET---------HAQGDCGRLC--CGRGFNITHEVNRY-KCDCQ-FV-----WCCQLQCNECIQHRWVSTCT + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + A5PFR0_HYDVU/21-343 + 0.32243 + + 20 + 132 + 81 + + + 6087 + HYDVU + Hydra vulgaris + Hydra + Hydra attenuata + species + + + A5PFR0 + Protein Wnt + wnt-8/11 + LCSSMAALQ----RKLHVTSKKVSP------DVVNSVILAYKDAFKNCYKNFKFERWNCPVPQAFSQ----------------------------INTPVSLTYTYPHA--TKETAYVYAIVAASILNRIVRNCRQGVY-QDLTCVKHS--------------------INGTQS-----------------------------------------------------------------------NQDESFSVNI-SNALKLVKRIIKIFDY-----KYVRDEKRKA--FNWNNSVIGLKAFTERLTTVCKCH---GLSGYCSSKT--------------------CWKSSLSSLKETAVELMTLYHG-AKKYEEQHQQSDPSTQST-------------------------------------------------------------------------------------------NVMKNFISKDVP----------NSSVLVYLTESPDYCKKNSSI-EVQGTLNREC-----------------NH---------HLDDSCKKLCSSCGYRKHSFVKTIENMQCNCK-FR-----WCCTVVCEKCVSRQISSRCS + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + 0.01538 + 40 + + 0.01916 + 89 + + 0.08359 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.01191 + 54 + + 20 + 71 + 142 + + + 0.01214 + 72 + + 20 + 71 + 142 + + + 0.01495 + 59 + + 20 + 71 + 142 + + + Q3L250_CHICK/18-321 + 0.07613 + + 20 + 71 + 142 + + + 9031 + CHICK + Gallus gallus + Chicken + species + + + Q3L250 + Protein Wnt + WNT9b + QCDLLKLSR----KQKRLCRREPG--------LAETLRDAIRLGIMECQFQFRSERWNCSLEG--------------------------------------RTSLLKRG--FKETAFLYAVSSAALTHSLARACSAGRM-ERCTCDDSP--------------------DLENRKA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKR--------IGKDLRAK--VDIHNTNVGIKAVKNGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHEIGRLLKLRYDD-AVKVFSTTNDAVGHSELA--------------------------------------------------------------------------------------------SPQRQSHPTKHHA------SPRATDLVYVEDSPSFCRPSKYS---LGTAGRTC-------------SRE-GN--------------CDSMC--CGRGYNTQSRLVTF-SCHCQ-VQ-----WCCYVECQQCMQEEVVYSCK + + branching involved in ureteric bud morphogenesis + + + in utero embryonic development + + + regulation of protein phosphorylation + + + regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis + + + proteinaceous extracellular matrix + + + regulation of asymmetric cell division + + + male genitalia development + + + regulation of tube size + + + positive regulation of catalytic activity + + + embryonic cranial skeleton morphogenesis + + + palate development + + + Wnt signaling pathway, planar cell polarity pathway + + + uterus morphogenesis + + + cornea development in camera-type eye + + + kidney rudiment formation + + + collecting duct development + + + establishment of planar polarity involved in nephron morphogenesis + + + metanephric tubule development + + + mesonephric duct formation + + + + + Q6ZSP0_HUMAN/73-350 + 0.11391 + + 20 + 71 + 142 + + + 9606 + HUMAN + Homo sapiens + Human + species + + + Q6ZSP0 + Protein Wnt + PPLAL--------RGRQATSKLPP--------FLSS-----PFPPSLC-------PW-----------------------------------------------VPDPG--FKETAFLYAVSSAALTHTLARACSAGRM-ERCTCDDSP--------------------GLESRQA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLSNFLGSKR--------GNKDLRAR--ADAHNTHVGIKAVKSGLRTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFRETGQVLKLRYDS-AVKVSSATNEALGRLELW--------------------------------------------------------------------------------------------APARQGSLTKGL-------APRSGDLVYMEDSPSFCRPSKYS---PGTAGRVC-------------SRE-AS--------------CSSLC--CGRGYDTQSRLVAF-SCHCQ-VQ-----WCCYVECQQCVQEELVYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q4S992_TETNG/27-324 + 0.09279 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4S992 + Protein Wnt + QCEQMSLSR----RQKRLCRREPG--------LAETLRESVRLSLLECRYQFRNERWNCSLDG--------------------------------------RGSLLKRA--FKETAFLLAVSSAALTHALAKACSSGRM-ERCTCDESP--------------------GIQHREA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKK--------VSKDLRAQ--VDAQNINVGVRAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLAPFHDTGRLLKYRYDN-AVRVLSVTNAATGETELA--------------------------------------------------------------------------------------------GPRRHSQNL------------RTTDLVYLEESPSFCRASRYS---PGTGGRSC-------------AKD-TS--------------CQSLC--CGRGYNTAMHLTSL-SCHCQ-VR-----WCCHVECQTCVREEEVYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A4ZGP2_XENTR/59-356 + 0.09489 + + 20 + 71 + 142 + + + 8364 + XENTR + Xenopus tropicalis + Western clawed frog + Silurana tropicalis + species + + + A4ZGP2 + Protein Wnt + wnt9b + QCDLLPLTR----RQRRLCRKEPG--------LAEALREAVRLGVVECQFQLRSERWNCSLQE--------------------------------------RGNLLKRG--FKETAFMYAISAASLTHSLAKACSGGRM-ERCTCDDSQ--------------------GLESQQA----------------------------------------------------------------------WQWGVCGDNL-RHSTRFLQNFLRQKK--------GGRDARAK--MDLHNSNAGIKAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHETGALLKAKYEN-AIKIHGASNEAVGGHE----------------------------------------------------------------------------------------------SLGHTFGGRHA----------RSTDFLYLEESPNFCRPSRFS---PGTAGRTC-------------LRE-NT--------------CDSLC--CGRGYNIQTRMVTF-SCHCQ-VH-----WCCHVECQKCVQQQETYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 7484 + xtr:100125200 + + + + + + WNT9A_HUMAN/58-364 + 0.12754 + + 20 + 71 + 142 + + + 9606 + HUMAN + Homo sapiens + Human + species + + + O14904 + Protein Wnt-9a + WNT9A + ACDRLKLER----KQRRMCRRDPG--------VAETLVEAVSMSALECQFQFRFERWNCTLEG------------------------------------RYRASLLKRG--FKETAFLYAISSAGLTHALAKACSAGRM-ERCTCDEAP--------------------DLENREA----------------------------------------------------------------------WQWGGCGDNL-KYSSKFVKEFLGRRS---------SKDLRAR--VDFHNNLVGVKVIKAGVETTCKCH---GVSGSCTVRT--------------------CWR-QLAPFHEVGKHLKHKYET-ALKVGSTTNEAAGEAGAI--------------------------------------------------------------------------------------------SPPRGRASGAGGSD----PLPRTPELVHLDDSPSFCLAGRFS---PGTAGRRC-------------HRE-KN--------------CESIC--CGRGHNTQSRVVTR-PCQCQ-VR-----WCCYVECRQCTQREEVYTCK + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + mitotic cell cycle checkpoint + + + cell-cell signaling + + + multicellular organismal development + + + negative regulation of cell proliferation + + + Wnt signaling pathway + + + neuron differentiation + + + negative regulation of chondrocyte differentiation + + + embryonic forelimb morphogenesis + + + negative regulation of cysteine-type endopeptidase activity involved in apoptotic process + + + cell fate commitment + + + positive regulation of cell differentiation + + + positive regulation of smoothened signaling pathway + + + embryonic skeletal system morphogenesis + + + canonical Wnt signaling pathway + + + negative regulation of cell death + + + negative regulation of cartilage development + + + iris morphogenesis + + + cornea development in camera-type eye + + + cellular response to retinoic acid + + + embryonic skeletal joint development + + + 7483 + hsa:7483 + 602863 + 29314 + PA37379 + + + + + + 0.12838 + 100 + + 0 + 173 + 193 + + + 7147 + Diptera + order + + + Q16S11_AEDAE/58-352 + 0.08512 + + 0 + 173 + 193 + + + 7159 + AEDAE + Aedes aegypti + Yellowfever mosquito + Culex aegypti + species + + + Q16S11 + Protein Wnt + PCRFLSGTR----RQNHQCRRDTG--------LPDAIKEARRLAVTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKV--YRETAFVHALTAAAITYSVARACAEGKM-AKCQCASEK--------------------RPEATRLA---------------------------------------------------------------------WKWGGCSDNI-KHGKRVTRNFLELQP--------ADGDPVAE--MLRHDSEVGIQAVTSTMNDRCKCH---GVSGSCSLKT--------------------CWR-KLGDFNATAAMLRTKYHH-AIRKIPINNKTSRRAI----------------------------------------------------------------------------------------------PKEFRE--REG----------SYDQLFYFETSPTFCSV---------TRGRRC-------------LHP-DN--------------CATLC--CGRGYTTKVVKTIE-KCRCR-FTN---GRCCQIVCDYCEKYEDRYYCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + WNT4_DROME/239-539 + 0.10493 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + P40589 + Protein Wnt-4 + Wnt4 + PCRYMPATR----RQNHQCRKETG--------LPGTLSEARRLATTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKL--YKETAFVHALTAAAMTHSIARACAEGRM-TKCSCGPKK--------------------HNREAQD----------------------------------------------------------------------FQWGGCNDNL-KHGKRVTRSFLDLRG--------GDGDEVSE--ILRHDSEVGIEAVSSQMMDKCKCH---GVSGSCSMKT--------------------CWK-KMADFNATATLLRQKYNE-AIRKAPNQRSMRQVSSSRM----------------------------------------------------------------------K-------------------KPKQRRKKPQQS----------QYTTLYYLETSPSYCAV---------TKDRQC-------------LHP-DN--------------CGTLC--CGRGYTTQVVKQVE-KCRCR-FNN---GRCCQLICDYCQRLENKYFCK + + establishment of imaginal disc-derived wing hair orientation + + + neural retina development + + + signal transducer activity + + + frizzled binding + + + protein binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + cellular component movement + + + salivary gland morphogenesis + + + motor neuron axon guidance + + + female gonad development + + + cell surface + + + Wnt signaling pathway + + + synaptic target inhibition + + + cell migration + + + retinal ganglion cell axon guidance + + + regulation of hemocyte proliferation + + + non-canonical Wnt signaling pathway + + + cell fate commitment + + + focal adhesion assembly + + + Wnt signaling pathway, planar cell polarity pathway + + + 54361 + 786401 + + + + + + + MOM2_CAEEL/44-362 + 0.27468 + + 132 + 40 + 122 + + + 6239 + CAEEL + Caenorhabditis elegans + species + + + Q10459 + Protein mom-2 + mom-2 + LCKNVPGLT---PQQKRMCHENPN--------IIKYLISGLRSALHTCEYTFQREAWNCTLTL-----------------------------------PGVGTSPLQIA--SRESAYVYAISAAGVSHSLARACSKGLI-DDCGCGETPQGSGS---------VAVSQASSRSSSD----------------------------------------------------------------------FVWAGCSDNV-KFGNTFGRKFVDQYDR------QHATEPRSQ--MNLHNNRVGRRLLVNAMNKECKCH---GVSGSCVTKT--------------------CWK-VMPKFDEFASRLHQKYQL-AKLVTNNDQKLTVRSSP---------------------------------------------------------------------------------------------SAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKD--------REC-------------GEN-----------------CPNIC--CGRGWRTTREIVDE-PCHCQ-FV-----WCCEVKCKTCKKLVERNYCL + + establishment of mitotic spindle orientation + + + endodermal cell fate specification + + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + establishment of cell polarity + + + neuron differentiation + + + receptor tyrosine kinase binding + + + asymmetric protein localization involved in cell fate determination + + + embryonic morphogenesis + + + 179217 + 904422 + + + + + + + Q589S1_DUGJA/51-361 + 0.24548 + + 153 + 112 + 0 + + + 6161 + DUGJA + Dugesia japonica + Planarian + species + + + Q589S1 + Protein Wnt + DjwntB + ICPMIFEES---SKEKNLCLTYPN--------MMVSIVYGAKLGLVECAQQFKFERWNCTFNESFPN-----------------------------MMTHHLHEMTVRS--VKETAFLFSIWSSGVVYSITNSCSKGDL-KECYCDPQR--------------------HGQDKDGSG-------------------------------------------------------------------DFTWGGCSDHI-KFGMKVSTIFLDNHD-------RKDQTGRSL--MNQHNNRVGRRVVWKTRLKKCKCH---GVSGACSLRT--------------------CWQ-RMNDFRRIGDMLKKLYNK-PQKVSYNPFQKS--------------------------------------------------------------------------------------------------LTFSRNQFRRP----------SKKRLVYIEQSQDYCIQDLTI-GHPGTGGREC-------------NYT-SS---------QHDS-CSELC--CNRGHYAYEMVVEE-NCDCK-FF-----WCCEVDAKYAGER---YSCI + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + 0.00547 + 3 + + 0.006 + 7 + + 0.03522 + 55 + + 0.07607 + 100 + + 0.07054 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.03271 + 96 + + 20 + 71 + 142 + + + 0.01268 + 86 + + 20 + 71 + 142 + + + 0.12585 + 100 + + 20 + 71 + 142 + + + 32443 + Teleostei + infraclass + + + WN10B_DANRE/47-427 + 0.07866 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + Q801F7 + Protein Wnt-10b + wnt10b + VCLRLAGLT---KKQMRLCVRSPD--------VTASALQGIQVAIHECQHQLRDQRWNCSSLENHG-------------------------------KLPHQSAILNRG--FRESAFSLSLLAAGVVHSVASACSLGKL-RGCGCEAKR--------------------RLDDDKIRLKLTQLQLQTFQRSGVSLAGAGENTPELSS--------LHGSLPANLHSSHPMSLLKPLPDEVTMLQDTWEWGGCSHDI-RFGVRFSRDWLDSRG--------SPRDIHAR--TRIHNNRVGRQVVTDNMRRKCKCH---GTSGSCQFKT--------------------CWY-VSPEFRLVGSLLREKFLT-AIFINSQNKNNGVFNSRTGGST----------------------------------------------------------------GSDP-L----------------RGQRRRS----------------ISRELVYFEKSPDFCDREPAV-DSLGTQGRIC-------------NKS-SP---------GMDG-CGSLC--CGRGHNILKQARSE-RCHCR-FH-----WCCYVLCEECKVTEWVNVCK + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + midbrain-hindbrain boundary development + + + cell fate commitment + + + canonical Wnt signaling pathway + + + 7480 + dre:30308 + 20806749 + + + + + Q4RW24_TETNG/23-401 + 0.06698 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4RW24 + Protein Wnt + VCLKLAGLS---KRQMRMCVRSPD--------ATASALQGIQVAIHECQYQLRDQRWNCSSLEGLG-------------------------------KVPHHNTILNRG--FRESAFSLAMLAAGVAHSVASACSMGKL-RGCGCEAKR--------------------RQDDDKIRLKLTQLQLQTLQKGGVGFGVTQSLSSELSG--------HHRDLPTNLRSTHPSGLLKPLPDDLSSLQETWEWGGCSHDV-RFGDRFSRDWLNSRG--------SPRDIHAR--MKIHNNRVGRQVVTDNMKRKCKCH---GTSGSCQFKT--------------------CWH-VSPEFRLVGSLLKEKFLS-AILVNSQNKNNGVFNSRNGVS------------------------------------------------------------------GST-G----------------GPGRRRS----------------MSRELVYFEKSPDFCERDSSV-DSAGTQGRIC-------------NKT-SH---------GTDS-CGSLC--CGRGHNILKKTQSE-RCNCR-FH-----WCCYVLCEECHLTEWVNVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A0JMB0_XENTR/45-388 + 0.08158 + + 20 + 71 + 142 + + + 8364 + XENTR + Xenopus tropicalis + Western clawed frog + Silurana tropicalis + species + + + A0JMB0 + Protein Wnt + wnt10b + VCLTLPGLS---KRQMGLCVRNPD--------VTASALQGIQIAIHECQHQLKGQRWNCSTLETMG-------------------------------KMPHDSAILKRG--FRESAFAFSLLAAGVMHSVATACSLGKL-QGCGCEWKR--------------------RGTEEKIRLKLNQLQLQALSKVKGLP---------------------------------RDLTPLLRETPEPSPQDTWEWGGCKHEL-EFGEKFSRDFLDSRE--------SPRDIHAR--MRIHNNRVGRQAVTENMKRRCKCH---GTSGSCQFKT--------------------CWH-VTPDFRAVGTLMRDKLQR-AVFVNSRNKNSGAFHPR---------------------------------------------------------------------------------------------LNKKR----------------LAKELVYFEKSPDFCEKDPRV-DSPGTQGRVC-------------NKT-SQ---------QMDN-CASLC--CGRGHNILMQTRRE-RCNCR-FH-----WCCYVMCEECRVTQLVNVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 7480 + xtr:780228 + + + + + + WN10B_HUMAN/47-389 + 0.08989 + + 20 + 71 + 142 + + + 9606 + HUMAN + Homo sapiens + Human + species + + + O00744 + Protein Wnt-10b + WNT10B + VCLTLSGLS---KRQLGLCLRNPD--------VTASALQGLHIAVHECQHQLRDQRWNCSALEGGG-------------------------------RLPHHSAILKRG--FRESAFSFSMLAAGVMHAVATACSLGKL-VSCGCGWKG--------------------SGEQDRLRAKLLQLQALSRGKSFPH----------------------------------SLPSPGPGSSPSPGPQDTWEWGGCNHDM-DFGEKFSRDFLDSRE--------APRDIQAR--MRIHNNRVGRQVVTENLKRKCKCH---GTSGSCQFKT--------------------CWR-AAPEFRAVGAALRERLGR-AIFIDTHNRNSGAFQPR---------------------------------------------------------------------------------------------LRPRR----------------LSGELVYFEKSPDFCERDPTM-GSPGTRGRAC-------------NKT-SR---------LLDG-CGSLC--CGRGHNVLRQTRVE-RCHCR-FH-----WCCYVLCDECKVTEWVNVCK + + G2/M transition of mitotic cell cycle + + + negative regulation of transcription from RNA polymerase II promoter + + + chondrocyte differentiation + + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + lipid metabolic process + + + cell cycle arrest + + + smoothened signaling pathway + + + positive regulation of cell proliferation + + + positive regulation of G2/M transition of mitotic cell cycle + + + myoblast differentiation involved in skeletal muscle regeneration + + + Wnt signaling pathway + + + neuron differentiation + + + positive regulation of bone mineralization + + + positive regulation of epithelial cell differentiation + + + regulation of proteasomal ubiquitin-dependent protein catabolic process + + + positive regulation of apoptotic process + + + cell fate commitment + + + negative regulation of fat cell differentiation + + + positive regulation of osteoblast differentiation + + + positive regulation of RNA polymerase II transcriptional preinitiation complex assembly + + + receptor agonist activity + + + regulation of skeletal muscle tissue development + + + skeletal muscle fiber development + + + negative regulation of epithelial cell proliferation + + + protein stabilization + + + sensory perception of taste + + + positive regulation of sequence-specific DNA binding transcription factor activity + + + positive regulation of anagen + + + canonical Wnt signaling pathway + + + bone trabecula formation + + + fungiform papilla development + + + cellular response to retinoic acid + + + cellular response to cAMP + + + cellular response to parathyroid hormone stimulus + + + hematopoietic stem cell proliferation + + + cellular response to hydrostatic pressure + + + positive regulation of canonical Wnt signaling pathway + + + 7480 + hsa:7480 + 225300 + 601906 + 29300 + 2440 + PA37377 + + + + + + 0.05315 + 98 + + 20 + 71 + 142 + + + Q53S44_HUMAN/60-417 + 0.09396 + + 20 + 71 + 142 + + + 9606 + HUMAN + Homo sapiens + Human + species + + + Q9GZT5 + Protein Wnt-10a + WNT10A + VCLTLPGLS---RRQMEVCVRHPD--------VAASAIQGIQIAIHECQHQFRDQRWNCSSLETRN-------------------------------KIPYESPIFSRG--FRESAFAYAIAAAGVVHAVSNACALGKL-KACGCDASR--------------------RGDEEAFRRKLHRLQLDALQRGKGLS--------------------------------HGVPEHPALPTASPGLQDSWEWGGCSPDM-GFGERFSKDFLDSRE--------PHRDIHAR--MRLHNNRVGRQAVMENMRRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRTVGALLRSRFHR-ATLIRPHNRNGGQLEPGPAGAP---------------------------------------------------------------SPAPG-A----------------PGPRRRA----------------SPADLVYFEKSPDFCEREPRL-DSAGTVGRLC-------------NKS-SA---------GSDG-CGSMC--CGRGHNILRQTRSE-RCHCR-FH-----WCCFVVCEECRITEWVSVCK + + hair follicle development + + + frizzled binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + positive regulation of gene expression + + + neural crest cell differentiation + + + Wnt signaling pathway + + + neuron differentiation + + + hair follicle morphogenesis + + + odontogenesis + + + regulation of odontogenesis of dentin-containing tooth + + + tongue development + + + skin development + + + cell fate commitment + + + epidermis morphogenesis + + + sebaceous gland development + + + cellular response to transforming growth factor beta stimulus + + + 80326 + hsa:80326 + 150400 + 224750 + 257980 + 606268 + 70863 + 2227 + 248 + 2721 + 50944 + 99798 + PA37817 + + + + + A4ZGN7_XENLA/44-389 + 0.05956 + + 20 + 71 + 142 + + + 8355 + XENLA + Xenopus laevis + African clawed frog + species + + + A4ZGN7 + Protein Wnt + wnt10a + VCLTVPGLT---RRQMEVCMRHPD--------VAASAIQGIQIAIHECQYQFQDHRWNCSSLETKN-------------------------------KIPYDSAVFSRG--FRESAYVYAIAAAGVVHAVSNACSMGKL-KSCGCDEKR--------------------RGDEEAFKAKLHRLQLEAMNRGKGM----------------------------------VHGVMEHLPADPPGPQDSWEWGGCSPDV-EYGERFSKEFLDSRE--------LFRDIHAR--MRLHNNRVGRQVVTDNMKRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRIIGSLLKDRFYG-ATLIKPHNRNTGQLEQAP-----------------------------------------------------------------------V-------------------PFRRRA----------------SINDLVYFEKSPDFCEQELNL-DSAGTQGRIC-------------NKT-SP---------GLDN-CESLC--CGRGHNILRQTRSE-RCNCK-FH-----WCCYVVCEECRITEWVSVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 80326 + xla:100049784 + + + + + + + 0.19929 + 100 + + 0 + 173 + 193 + + + 7147 + Diptera + order + + + Q17NQ1_AEDAE/7-386 + 0.09394 + + 0 + 173 + 193 + + + 7159 + AEDAE + Aedes aegypti + Yellowfever mosquito + Culex aegypti + species + + + Q17NQ1 + Protein Wnt + TCRTVPGLT---REQLELCYRASD--------VTAAAIEGLELGVRECQHQFQWHRWNCSSLSTKS-------------------------------RNPHTSSMLKRG--YRESAFAYAVAAAGVTHSVARACAQGRL-ISCGCDPSVNRKGM---------TKSLRESLEKEKLRFLDAINENSILVD-------------------------------------------DSLKKLKTKQASRWKWGGCSHNM-AFGVEFSELFLDTRE--------KGGDIQSQ--INLHNNHAGRRAVSNNMQVRCKCH---GMSGSCQLKT--------------------CWK-SAPDFRVVGKVLKQQYRR-AVLVDQSNLGNGPPMIVYHKPKKRKHVNNV-----------------------------------------------RPPRRTKDKGQQQ-QQRH----------LIPISRANRK----------------MENALFYYQRSPNFCERDQVS-DIPGTVGRRC-------------NRT-SV---------GSDG-CASMC--CGRGYNLIREKRVD-RCNCK-FH-----WCCYVECDDCEIEEWISVCN + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q9VM25_DROME/24-432 + 0.22204 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + Q9VM25 + Protein Wnt + Wnt10 + TCRSVPGLT---KDQVELCYKASD--------VTAAALEGLDMAIRECQIQFQWHRWNCSSLSTKS-------------------------------RNPHASSLLKKG--YRESAFAFAISAAGVAHSVARACSQGRL-MSCGCDPTINRKTL---------NKNLRQSLDKEKKQFLQYLETNQILTP------------------------------------------EEEKKYERSKIASRWKWGGCSHNM-DFGVEYSKLFLDCRE--------KAGDIQSK--INLHNNHAGRIAVSNNMEFRCKCH---GMSGSCQLKT--------------------CWK-SAPDFHIVGKVLKHQFRK-AILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGSTSPDLDS--------------------------TDASGGHDDGGTGDSETRRHDEL-GVERGTRQ---PSADKNAARMARK----------------LETSLFYYQRSPNFCERDLGA-DIQGTVGRKC-------------NRN-TT---------TSDG-CTSLC--CGRGHSQVIQRRAE-RCHCK-FQ-----WCCNVECEECHVEEWISICN + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + 34011 + 786423 + + + + + + + Q5J2D3_NEMVE/42-349 + 0.16933 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5J2D3 + Protein Wnt + VCKNTPSLS---KEQLKMCRRLPD--------VVASALQGMQYAIHECLAQFRYRRWNCSSLEMKN-------------------------------RNPLANPLLSRG--FRETAFVHAILSAGMTSSVARACSMGKL-AKCGCDESL--------------------RGRGTG-----------------------------------------------------------------------WEWGGCGDNI-DYGIETSAKFLDSRE--------KGRDLHSM--MNMHNNMVGRTTLSENAKTKCKCH---GMCGSCSVKT--------------------CWK-TVPDIREIGDRLMEKYDH-ATTIGMGNGRLRLHLTRR-------------------------------------------------------------------------------------------KARRSS----------------VGRALVYYEDSPNYCIENKEL-GIFGTRGRIC-------------SPE-SL---------DTDN-CQNLC--CERGYTTKKLQVTK-RCRCH-FS-----WWCYLICDTCRETSTVSICS + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.02092 + 12 + + 0.05896 + 74 + + 1206794 + Ecdysozoa + + + Q9VM26_DROME/49-435 + 0.37993 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + Q9VM26 + Protein Wnt + Wnt6 + MCKKTRRLR---GKLAEICRHDSA-------LLKEIIINGINLGFRECEFQFRNRRWNCTVLR-----------------------------------KSMRK-ILMRD--SRETGFVNAITAAGVTYAVTKACTMGQL-VECSCDKAHMRRNG---------GQPQMVTAATAEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNNASTMTDIAPVEHRGGRNRRPGGRRGRRKFWDNIKFPEGQWEWGGCSDNV-NFGLRHSRVFLDAKQR------QRRSDLGTL--VKFHNNNAGRLAIRDAMRLECKCH---GLSGSCTVKT--------------------CWL-KMPPFREVAGRLRDRYDS-ARKVTLRNDGNSFMPE----------------------------------------------------------------------------------------------SPHAR----PA----------NKYQLVFADDSPDFCTPNSKT-GALGTQGREC-------------NVT-SS---------GSDR-CDRLC--CNRGHTRRIVEEQT-NCKCV-FK-----WCCEVTCEKCLEHRAVNTCL + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + regulation of imaginal disc-derived wing size + + + cell fate commitment + + + 7475 + 786418 + + + + + Q5IWR0_PRIPA/50-417 + 0.31534 + + 132 + 40 + 122 + + + 54126 + PRIPA + Pristionchus pacificus + Parasitic nematode + species + + + Q5IWR0 + Protein Wnt + wnt + LCAHLTGLN---PVQQQICTSHPF--------SIPFVSRGLRDAIYECQQQFKMERWNCSDRYEIMKTP-------------------------YGYFHDILGKTLRTT--TKESSYLAAIASAGIVYAVTKGCNTGNF-SDCGCDSKPALQRH---------LEAIELNPPSAAALTSMHPGGPVPYPPPPGM----------------------------------PSSAYPPMGSNGMTGNGPFSWGGCSDNV-GYGVRYARKFLDEFERQ---EFNRTSNVQHL--VAMHNHFVGREAIVQNVRKHCRCH---GVSGSCEFKT--------------------CWL-QMPKMKDVAELLKKRYDNFAVQVTKRAKKRL--------------------------------------------------------------------------------------------------RRKERSERATP---------IRGNEMAFVVRSPTYCERNDTA-GILGTAGRDC-------------VHD-SL---------NADS-CDLLC--CGRGYNTRIERQVT-QCNCK-FV-----WCCQVKCKECVDDVALHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.08769 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + WNT6_MOUSE/39-364 + 0.13199 + + 20 + 71 + 142 + + + 10090 + MOUSE + Mus musculus + Mouse + species + + + P22727 + Protein Wnt-6 + Wnt6 + ICRKARRLA---GRQAELCQAEPE--------VVAELARGARLGVRECQFQFRFRRWNCSSHS-----------------------------------KAFGR-VLQQD--IRETAFVFAITAAGASHAVTQACSMGEL-LQCGCQAPRGRAPPRPSGLLGTPGPPGPTGSPDASAA---------------------------------------------------------------------WEWGGCGDDV-DFGDEKSRLFMDAQHK------RGRGDIRAL--VQLHNNEAGRLAVRSHTRTECKCH---GLSGSCALRT--------------------CWQ-KLPPFREVGARLLERFHG-ASRVMGTNDGKALLPA----------------------------------------------------------------------------------------------VRTLK----PP----------GRADLLYAADSPDFCAPNRRT-GSPGTRGRAC-------------NSS-AP---------DLSG-CDLLC--CGRGHRQESVQLEE-NCLCR-FH-----WCCVVQCHRCRVRKELSLCL + + branching involved in ureteric bud morphogenesis + + + receptor binding + + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + endoplasmic reticulum lumen + + + signal transduction + + + cell-cell signaling + + + axis specification + + + organ morphogenesis + + + cell surface + + + positive regulation of gene expression + + + Wnt signaling pathway + + + neuron differentiation + + + extracellular matrix + + + odontogenesis of dentin-containing tooth + + + cell fate commitment + + + positive regulation of transcription, DNA-templated + + + epithelial-mesenchymal cell signaling + + + positive regulation of tooth mineralization + + + nephron tubule formation + + + nephron tubule development + + + 7475 + mmu:22420 + 302849 + + + + + Q4RNC9_TETNG/40-334 + 0.07486 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4RNC9 + Protein Wnt + ICRKAKRLA---GKQAELCQTQPE--------IVREVAKGARLGVRECQYQFRYRRWNCTSHN-----------------------------------KYFGK-ILQQD--IRETAFVYAITAAGVTHAVTQACSMGDR-PQCGFK----------------------------------------------------------------------------------------------------WEWGGCVDDV-EFGYEKSKQFMDAKRR------RGKSDIRAL--IDLHNNEAGRLAVKLYMRTECKCH---GLSGSCTLRT--------------------CWR-KMPHFREVGDRLLERFNG-AFKVMGSNDGKTLIPV----------------------------------------------------------------------------------------------GQNIK----PP----------DKQDLIYSDDSPDFCLANRKT-GSLGTRGRTC-------------NST-AM---------DISG-CDLLC--CERGYQEETVVFEE-NCLCH-FH-----WCCVVQCKKCFVRKELSLCH + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + + 0.01935 + 33 + + 0.10758 + 100 + + 153 + 112 + 0 + + + 6157 + Platyhelminthes + phylum + + + Q589S7_DUGJA/76-402 + 0.16397 + + 153 + 112 + 0 + + + 6161 + DUGJA + Dugesia japonica + Planarian + species + + + Q589S7 + Protein Wnt + Djwnt-A + ICQTFSR------HQRKLCNQHFR--------LMESVVNGFLLGLNECQFQFADQIWNCKGHNMTIGGNRSK-------------------SKPRKKGKTYLDKLVSKG--TPEAAYVLSVISAGVAHQVTKACSKGVH-DSCGCDRTI--------------------YDIPETAT---------------------------------------------------------------------FKWSGCSHNI-HFGAAFTRQFLDITEKT----RVNKRPEKAL--TKLHNNHVGRQAVILKMGKKCKCH---GVSGSCEMKT--------------------CIR-ALPDFRVVGDLLKSRFHK-AMQVHFVDSRLIPRYSPNR----------------------------------------------------------------------M-------------------F---------------------TDNDLIYLLKSPNYCVHNPHI-GSLGTQGRKC-----------------AESALLEKKPGETNGTCEELC--CGRGHKKRTFSRME-QCRCK-FQ-----WCCDVKCDLCKKDVIESVCD + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + A6XBT4_SCHJA/38-436 + 0.34628 + + 153 + 112 + 0 + + + 6182 + SCHJA + Schistosoma japonicum + Blood fluke + species + + + A6XBT4 + Protein Wnt + ICDHPNGFL---RRQKKLCRQYLH--------LMESVIRGYFMGLKECEYQFSAHRWNCQGHNLTIQAPTSRKQKRLRYRESELKNDMDNSRRKSVRIQTYLDKLLSKG--TRESAYVLAVTSAGVSHAVTKACSSGLH-DNCGCDRTI--------------------YDHPREPN---------------------------------------------------------------------FEWSGCSDNI-HFGAAFSRQFLDVRERN----RLKRNPKLGL--TNLHNNHVGRHMVINKMEVQCKCH---GVSGSCEMRT--------------------CWR-SLPKFRHLGAQLQERFHE-AIQVTYIQNRLVSMKALEQLSKESNGNALLLS-------------------------------------------HSALLSSVVSGVSSS-DELPA---------SPRINRNAFDTLTRSTSLTTSPLPSPTENDLIYISESPTFCHHDPRY-GSIGTYGRQC-------------DEN-SQ---------GLNS-CNYLC--CGRGFKRQTFVQQE-RCDCK-FQ-----WCCKVVCKTCRKTVVISTCN + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.01599 + 42 + + Q4H305_CIOIN/224-608 + 0.45291 + + 20 + 71 + 142 + + + 7719 + CIOIN + Ciona intestinalis + Transparent sea squirt + Ascidia intestinalis + species + + + Q4H305 + Protein Wnt + Ci-Orphan Wnt e + ICLWAQQIG---GPQAEMCANEMP--------VVEEIKKGIQRGAYNCAREFRYSRWNCSQTP-----------------------------------KKFYEKALWQT--TKETSYLQAVTSAAMTFAITEACSLGNI-PECGCVNTRGQKRE---------YLRREAQKRNYYINESYLD-----------------------------------------------------------TFVDQFDWEGCDDNV-DFAYRKTRHFLNFTRFI---GRKRKINLRLR--MSAHNYEAGRLAITEKMAEKCKCH---GFSGTCTIRT--------------------CWM-RMPKFDAVRATLRRMYNT-ATKVNLQPGTRRLVIARRPRRPSSRHRNTAS---------------------------------------------RRTNKVKRGLRKNI-PTRFR---------SRNRKAKNPRRRIRLKNRLRRRLYPVASKHLVYHQPSPNFCRRDKRK-GSLGTKGRVC-------------DPTRRE---------GYGS-CQYMC--CGRGYTTEVVEHTM-KCNCT-FI-----YCCTMTCDECINRYTRYVCR + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + cin:778723 + + + + + A7RSC1_NEMVE/46-365 + 0.20497 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + A7RSC1 + Protein Wnt + FCSLMPWMK---PHQKQKCLLEPL--------VMPSVQRGVGMALEECPNHFSDHKWNCSGVNTA--------------------------------QVFQERGILKTN--TKESAFVFALTSAGVSFQITKGCSLGNW-EQCGCDTQV--------------------RGRVQTKDE------------------------------------------------------------------ASWEWGGCSENV-GHGDDFSRKFMDPEP--------PRKELEYL--LVKHNNEAGRKALKDNMGKTCKCH---GVSGSCTVKI--------------------CWR-TMPNFSVVAQLLRKKFDQ-ATKVKANDKKTKLQRITRG----------------------------------------------------------------------K-------------------RGKKKRQKGRRP----------SAGDLVFAEKSPKFCIPNPEL-GILGTRGRVC-------------DAN-AK---------DNRG-CKKMC--CNRGYDTFKLSNQV-KCNCE-FI-----WCCKVQCDMCKKDWTEYRCR + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + + + 0.00747 + 19 + + 0.01858 + 71 + + 0.0051 + 53 + + 0.00652 + 53 + + 0.00581 + 59 + + 0.02867 + 100 + + 0.01102 + 73 + + 9.5E-4 + 32 + + 0.0061 + 43 + + 0.03722 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + A1BPR0_DANRE/62-374 + 0.06379 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + A1BPR0 + Protein Wnt + wnt5a + LCSQLSGLS---KGQKKLCQLYQD--------HMQYIGEGAKTGIRECQHQFRHRRWNCSTVDNS---------------------------------TVLGR-VMHIG--SRESAFAFAISAAGVLHAVSRACREGAL-SSCGCSRAS--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNL-NYGYRFSREFVDAREREKTFSKGSAESARQM--MNLHNNEAGRRIVSDLADVSCKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGDVLKEKYDS-AAAMRMNGRGKLVQM-----------------------------------------------------------------------------------------------HSKFS----PP----------SGQDLLYLQPSPDYCIRNSSS-GSLGTQGRLC-------------NKT-SE---------GMDG-CALMC--CGRGYDQYKAELVE-RCHCK-FH-----WCCYVRCKRCSSIVDQYVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 7474 + dre:568191 + 20889048 + + + + + Q6DII0_XENTR/48-360 + 0.05868 + + 20 + 71 + 142 + + + 8364 + XENTR + Xenopus tropicalis + Western clawed frog + Silurana tropicalis + species + + + Q6DII0 + Protein Wnt + wnt5b + LCSQLTGLS---PGQRKLCQLYQD--------HMVYIGEGAKTGIKECQHQFKHRRWNCSTVDNN---------------------------------SVFGR-VMQIG--SREAAFTYAISAAGVVNAISRACREGEL-STCGCSRTP--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNV-EYGYRFAKEFVDAREREKNFPKGSEEQARSL--MNLQNNEAGRRAVYKLADVACKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGEYIKEKYDS-AASMRLNKRNKLEQV-----------------------------------------------------------------------------------------------NQRFN----PP----------TAEDLVYLDPSPDYCLYNETT-GSLGTHGRQC-------------NKT-SE---------GMDG-CELMC--CGRGYDQFKTVQVE-RCHCK-FH-----WCCFVKCKKCTEIVDQYVCK + + angiogenesis + + + chondrocyte differentiation + + + thrombocyte differentiation + + + proteinaceous extracellular matrix + + + intracellular + + + Wnt signaling pathway, calcium modulating pathway + + + regulation of Wnt signaling pathway, calcium modulating pathway + + + unidimensional cell growth + + + embryonic body morphogenesis + + + endocrine pancreas development + + + fin regeneration + + + otolith development + + + neuromast development + + + release of sequestered calcium ion into cytosol + + + convergent extension involved in axis elongation + + + dorsal convergence + + + somite development + + + 81029 + xtr:448452 + + + + + + O96867_STRPU/19-331 + 0.09595 + + 40 + 20 + 71 + + + 7668 + STRPU + Strongylocentrotus purpuratus + Purple sea urchin + species + + + O96867 + Protein Wnt + spwnt-5 + LCSELLGLS---PGQQKLCQLYQD--------HMAPIGEGAKMSIDECQNQFTNRRWNCSTVDSN---------------------------------NVFGK-VLSIS--SREAAFTYAITSAGVVNAISRSCREGQL-STCGCGKSP--------------------RPPDIPRD---------------------------------------------------------------------WVWGGCGDNI-DYGFRFAREFVDAREMETNPQRGSFAYDRMK--MNLHNNEAGRKAVYDNAGTECKCH---GVSGSCSLKT--------------------CWL-QLSPFNRVGTILKDKYDG-ATNVRVNKKGRLVNS-----------------------------------------------------------------------------------------------DARFN----KP----------TRDDLVYLQPSPDYCLPDIQT-GSLGTTGREC-------------NKT-SM---------GTDG-CTLMC--CGRGYNSFTKEVVE-RCKCK-FK-----WCCYVKCRKCRTLVDVHVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q8WS75_BRAFL/55-370 + 0.10636 + + 20 + 71 + 142 + + + 7739 + BRAFL + Branchiostoma floridae + Florida lancelet + Amphioxus + species + + + Q8WS75 + Protein Wnt + Wnt5 + LCTTLAGLS---SGQRKLCNLYQD--------HMSSVGIGARQGIEECQHQFRDRRWNCTTSDED---------------------------------SVFGR-IVNIG--SREASFTYAIAAAGVVNAVSRACREGEL-TTCGCSRAK--------------------RPKDLNRD---------------------------------------------------------------------WLWGGCGDDV-EYGYYFAREFVDAQEKQIIPTPGSQAHARQL--MNMHNNEAGRKLTFSNARVACKCH---GVSGSCSLKT--------------------CWQ-QLADFRTVGNLLKDKYDG-ANEVKLIKRGKRYRLDRR--------------------------------------------------------------------------------------------NPRFN----VF----------TDEDLVYLNKSPDYCNADPTI-GSLGTHGREC-------------NKT-GL---------GTDG-CNLMC--CGRGYNTFKREKVE-RCNCK-FH-----WCCYVKCKRCRSIKNVYVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q75PH7_PARTP/66-378 + 0.11208 + + 0 + 173 + 193 + + + 114398 + PARTP + Parasteatoda tepidariorum + House spider + Achaearanea tepidariorum + species + + + Q75PH7 + Protein Wnt + wnt5 + LCSRLSGLS---RGQTKLCYLYQD--------HMAHVARGARLGIHECQWQFKNRRWNCSTVDDS---------------------------------SVFGP-VLNIG--SREAGFAHAVAAAGVVHTVSRGCRDGQL-SNCGCSRAM--------------------RPKNLHRD---------------------------------------------------------------------WIWGGCGDNI-EYGYRFTEGFVDVKEREINHARGSREQGRKL--MNLHNNEAGRRAVIRKVRVTCKCH---GVSGSCSLVT--------------------CWQ-QLAPFREVGDYLKDKYDG-ATEVKINHRGKLQIR-----------------------------------------------------------------------------------------------NPRYN----LP----------TAEDLVYVDESPDYCVPNEET-GSWGTEGRVC-------------NRT-SP---------STDG-CNLMC--CGRGYNTHKTTIKE-RCKCK-FH-----WCCYVECKTCHYVLDIQSCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A2SXV2_9MOLL/64-376 + 0.12755 + + 255 + 122 + 142 + + + 6613 + 9MOLL + Euprymna scolopes + phylum + + + A2SXV2 + Protein Wnt + Wnt5 + MCVALKGLS---PGQIRICQLFYD--------HMPSVGRGAQLGIRECQYQFRNRRWNCSTVNDE---------------------------------SVFGP-VMELG--SRETGFTHAVSSAGVVYSVSRACPEXQL-SRCGCSKAP--------------------RPPIHKD----------------------------------------------------------------------WLWGDCGDNI-EHGYRFALGFIDKREKERNYPRFSRGLARML--MNLHNNEAGRRAIYKHATVSCKCH---GVSGSCSLKT--------------------CWQ-SSPDFRSVGNRLKEKYNG-ATKVRFNSRGTRLIRR----------------------------------------------------------------------------------------------DHKFN----KP----------TKEDIIYLDDSPDYCMAKPEA-GVLGTVGREC-------------NWT-SK---------GLGG-CALMC--CGRGYNSFRKKVQE-RCHCK-FE-----WCCEVKCDLCEYFVDVHVCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.0412 + 100 + + 20 + 71 + 142 + + + 7713 + Ascidiacea + class + + + 0.01291 + 87 + + 20 + 71 + 142 + + + Q9U6V0_CIOIN/49-360 + 0.10739 + + 20 + 71 + 142 + + + 7719 + CIOIN + Ciona intestinalis + Transparent sea squirt + Ascidia intestinalis + species + + + Q9U6V0 + Protein Wnt + wnt5 + ICGQLEGLS---RNQRALCQRYAN--------HMAHVSEGAGIGINECKWQFRGQRWNCSTVDDS---------------------------------SVFGK-VLKIG--SKETAFTYAISAAGVVVAVARACKNEQL-ENCGCGNKA--------------------RPEGLDAS---------------------------------------------------------------------WRWGGCGDNT-EYAYGFAREFIDARERDNISPKRRKDRERKV--MNMHNNEAGRMVVVRSARPTCKCH---GVSGSCSLKT--------------------CWM-QVPGFREIGDELMRKYIG-GVEVRVTNRGQLRPRR----------------------------------------------------------------------------------------------SNDEV----------------GSTSLVYLDSSPDYCDKNRRT-GVAGTKGREC-------------KKD-SS---------GPEG-CGLLC--CGRGFRTYRVRVVE-KCECK-FQ-----WCCSVKCNLCQRTVKRHICR + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + Wnt signaling pathway + + + neuron differentiation + + + cell fate commitment + + + 32838 + cin:445761 + + + + + Q8T8A8_HALRO/49-371 + 0.13419 + + 20 + 71 + 142 + + + 7729 + HALRO + Halocynthia roretzi + Sea squirt + Cynthia roretzi + species + + + Q8T8A8 + Protein Wnt + HrWnt-5beta + PCSEIPSLS---HSQRALCQKYRD--------HILLVSEGAQKGIEECQYQFRARRWNCSTTTNKKRKID-----------------------NNDSSTVFGK-VIDIG--SRETAFTYAISAAGVVHAIARGCKEGRL-EACGCSNSP--------------------RPDGLRDE---------------------------------------------------------------------WEWGGCGDNL-DYAYGFAHEFIDARERDNVSPRNLKSRSRKV--MNLHNNEAGRMTVVRGARPTCKCN---GVSGSCSLNT--------------------CWL-RVPHFREIGDKIREKHDS-SIEIKVNKRSRMRPR-----------------------------------------------------------------------------------------------KKSIE----SP----------TITDLVHLDSSPDYCRANSRT-GVLGTKGREC-------------NAH-SD---------GSDG-CGLMC--CGRGYDTRVVDVEE-RCNCR-FQ-----WCCVVRCQKCIKRVQRYICR + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + WNT5_HALRO/52-363 + 0.135 + + 20 + 71 + 142 + + + 7729 + HALRO + Halocynthia roretzi + Sea squirt + Cynthia roretzi + species + + + O15978 + Protein Wnt-5 + WNT5 + HCDEIRGLS---RNQRSLCRTYND--------HMYYVESGSKQGVEECQWQFRGQRWNCSLASN----------------------------------ASPDK-IIAVG--SKETAFTYAITSGGVVQSIARACKSGNL-MACGCSKRE--------------------RPTGLGKD---------------------------------------------------------------------WNWGGCGDDI-DYAYGFAHEFIDAQERDNSSPNDRRVKSHKA--MNIHNNEAGRLSVVRASHTTCKCH---GVSGSCSIKT--------------------CWL-QTPQFRTIGDKLRQRYDD-ALEMRVTHRGQMKTR-----------------------------------------------------------------------------------------------FSSDR----NP----------SNIDLVYIDSSPDYCKVNHKL-GILGTSGREC-------------QLD-SL---------AMDG-CGLMC--CGRGYTTKMVEVVK-SCNCK-FQ-----WCCFVKCQQCKEKVLKHICN + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + A8WV10_CAEBR/44-360 + 0.18334 + + 132 + 40 + 122 + + + 6238 + CAEBR + Caenorhabditis briggsae + species + + + A8WV10 + Protein CBR-CWN-2 + cwn-2 + PVCELPGLS---PGQAQVCELFKD--------HMPAVSIGAQNAIQECQRQFTGHRWNCSTHYST---------------------------------GMLGP-IHKMA--TREAAFTYAILSAGVTHEIGRRCKQGLL-TSCGCSDET--------------------KPKNVPTD---------------------------------------------------------------------WSWGGCGDNV-EYGYKFSRDFIDIREKEH-DPKRNHDNGRSL--MNRRNNEAGRKILKRHRKPKCKCH---GVSGACNMKT--------------------CWM-QLPSMEQVGKILRNKYDK-AIRVQINDRGNLQLLA----------------------------------------------------------------------------------------------DETSKERKTRA----------LPTDLVFMDDSPDYCRFDRHS-GTLGTEGRVC-------------KRG-SS---------GAEG-CDSLC--CGRGYNTYTQEVKS-KCNCK-FE-----WCCKVVCQTCNNMTQVDICK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 8575733 + + + + + + Q5IHW1_NEMVE/31-358 + 0.21141 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IHW1 + Protein Wnt + Wnt5 + LCMNLGGLT---REQIDLCQKNID--------HMASVGLGAKMAIQECQFQYQYEKWNCSIPDAEK-------------------------------SSLFER-ITSKDVATREAALTYAISSAGVVWALARACTEGNL-STCSCSRER--------------------RPLDLNKE---------------------------------------------------------------------YQWGGCGDNI-EYAVKFGREFMEAGEDHRPTEEDRKKYARTL--MNLHNNNLGRRVVKDISVVECKCH---GVCGSCNLKT--------------------CWR-QLVEFREIGNALHDKYDA-AVQVALKRKEGRSLLLPMR---------------------------------------------------------------------SR-------------------HYSQRKAKSAQE----------TRDELVYIDKSPDFCSKNAAH-GAQGTRGRKC-------------IKE-SL---------GKDG-CNLLC--CSRGYKMKKEVQAT-RCRCK-FH-----WCCKVKCKTCIKNVTTHICN + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + A5AA55_HYDVU/16-337 + 0.23324 + + 20 + 132 + 81 + + + 6087 + HYDVU + Hydra vulgaris + Hydra + Hydra attenuata + species + + + A5AA55 + Protein Wnt + wnt5 + ICDKRRSLT---EKQIKLCNTNSD--------HMAYIIEGRRIAIEECMKQFSDRGWNCTFPEPN--------------------------------IIPFLHPYMPLG--TRETAFVHSIIAAATMHSISRACMENKLSSHCSCSQEK--------------------KPENLPKT---------------------------------------------------------------------DMWNGCGDNL-PYGYQFSKEFVDSKETIL--KDSAFNFGRVL--MNLHNNEAGRWAVFEKSKIQCRCH---GVSKNCATKT--------------------CYR-QLSEFKDVGYQLEQLHQS-AIHVQLSQSGQKNDTEIT-------------------------------------------------------------------------------------------KLVQFNSNIDIY----------TSKDMIYLDDSPSYCNQNLSI-GSFGTEGREC-------------IKD-DN---------SSKE-CGRLC--CEKGHYTKKVFTTE-NCACK-FI-----WCCEVKCQSCKKQQNKHYCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.00466 + 21 + + 0.03316 + 100 + + 0.01423 + 92 + + 0.00736 + 20 + + 0.00804 + 24 + + Q9TZT6_BRAFL/41-353 + 0.09109 + + 20 + 71 + 142 + + + 7739 + BRAFL + Branchiostoma floridae + Florida lancelet + Amphioxus + species + + + Q9TZT6 + Protein Wnt + Wnt4 + ACEKLHGLI---SRQVQICKRNVE--------VMDSVKEGARMSIEECQFQFRHRRWNCSTLINRR-------------------------------GPVFGK-VLEEG--TREAAFVHSISAAGVAHAVTRACSSGEL-ERCGCNRTV--------------------RGTIPEG----------------------------------------------------------------------FHWAGCSDNF-AFGAAFSQTFVDARERG----RVAATSSRAL--MNLHNNEAGRRNLVDHMKTECKCH---GVSGSCELKT--------------------CWR-AMPPFREVGARLKEKFDG-ATEVQQKKIGSRRELVPL--------------------------------------------------------------------------------------------NSDFK----PH----------SSSDLVYLDASPDFCVRDTKV-GSMGTVGRVC-------------NKT-SK---------AIDG-CELLC--CGRGYNTHTREVVE-RCSCK-FH-----WCCYVKCKTCRRTVEVHTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q8MPL6_PLADU/43-355 + 0.09896 + + 0 + 132 + 132 + + + 6359 + PLADU + Platynereis dumerilii + Dumeril's clam worm + species + + + Q8MPL6 + Protein Wnt + wnt4 + ECNVLDGLV---KKQKKICKKHVE--------MMGAVRKGAIEAIHECQFQFRNRRWNCSTVDAS---------------------------------TIFGN-VLHQG--SREASFVHAISSAGVAHPVTRACSSGTM-SECGCDRTV--------------------RGRSPAG----------------------------------------------------------------------FEWAGCSDNI-AFGTAFSRTFVDARERVR--KDREGSSSRVL--MNLHNNEAGRKIIEENMLTQCKCH---GVSGSCELKT--------------------CWR-AMPSFRKIGYMLKEKFDG-ACEVQQKKAGSRSVLVPR--------------------------------------------------------------------------------------------STQYK----PH----------SSTDLVYLVASPDFCERDPKT-GALGTHGRRC-------------NKT-SK---------AIDG-CELMC--CGRGYVTKKRVIIE-RCHCK-FH-----WCCYVKCQNCKREIEEHTCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.01701 + 54 + + 20 + 71 + 142 + + + 7955 + Danio rerio + Zebrafish + Brachydanio rerio + species + + + Q1RLW9_DANRE/42-352 + 0.0857 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + Q1RLW9 + Protein Wnt + wnt4a + TCEKLRGLI---QRQVQICKRNVE--------VMDAVRRGAQLAIDECQYQFRNRRWNCSTLESV---------------------------------PVFGK-VVTQG--TREAAFVYAISAASVAFAVTRACSSGEL-DKCGCDRNV--------------------HGVSPEG----------------------------------------------------------------------FQWSGCSDNI-AYGVAFSQSFVDIRER-----SKGQSSNRAL--MNLHNNEAGRKAILNHMRVECKCH---GVSGSCEVKT--------------------CWK-AMPPFRKVGNVIKEKFDG-ATEVELRKVGTTKVLVPR--------------------------------------------------------------------------------------------NSQFK----PH----------TDEDLVYLDPSPDFCEHDPRTPGIMGTAGRFC-------------NKT-SK---------AIDG-CELMC--CGRGFHTEEVEVVD-RCSCK-FH-----WCCYVKCKQCRKMVEMHTCR + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + heart development + + + Wnt signaling pathway + + + habenula development + + + neuron differentiation + + + cell migration involved in gastrulation + + + cell fate commitment + + + positive regulation of transcription, DNA-templated + + + regulation of axon extension involved in axon guidance + + + canonical Wnt signaling pathway + + + sensory epithelium regeneration + + + 30123 + dre:30123 + 20806602 + + + + + A3KQ12_DANRE/46-357 + 0.10852 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + A3KQ12 + Protein Wnt + wnt4b + PCGRLRGLS---PGQVGVCRARGE--------VMESVRKASEMVIEECQHQFRNRRWNCSTTPRG--------------------------------INVFGR-VMNQG--TREAAFVHALSSAAVAVAVTRGCSRGEL-ERCGCDRKV--------------------RGVSPEG----------------------------------------------------------------------FQWSGCSDNL-SYGVAFSQTFVDEPER-----AKGMSSGRPL--MNIHNNEAGRKAILHNMQVECKCH---GVSGSCELRT--------------------CWK-VMPPFRRVGAVLKERFDG-ATEVRLTRVGSRTALLPR--------------------------------------------------------------------------------------------DPQVK----PP----------ATRDLVYLAPSPDFCRLDPDN-GIPGTAGRRC-------------NGT-SR--------LAPDG-CELLC--CGPGFRAGRAEVVQ-RCSCK-FS-----WCCSVRCQQCKNTVLIHTCR + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + A2SVS6_9MOLL/48-358 + 0.12714 + + 255 + 122 + 142 + + + 6613 + 9MOLL + Euprymna scolopes + phylum + + + A2SVS6 + Protein Wnt + ECDNLTGLV---KRQKKICKKNLE--------MMNSVKQGAILAIQECQMQFRNRRWNCSSIDKL---------------------------------SLPGN-ILNRG--TREAAFVHAISAAAVAHSVTRACSSGKM-ERCGCDRTV-------------------HKNVTVQNS---------------------------------------------------------------------FLWSGCSDNV-AYGAAFSQRFVDARER------RRKINGRVL--MNLHNNQAGRNAIENHMKTMCKCH---GVSGACEMRT--------------------CWR-AILSFRKIGNLLREKFDG-ATEVRPKRKGSKRVLIPM--------------------------------------------------------------------------------------------NPKFK----HH----------TPNDLVYLLVSPDFCEPDNKT-GIPGTHGRLC-------------NLT-SK---------AIDG-CELMC--CGRGFNHRQRITSE-RCNCK-FN-----WCCVVECLMCPVVIEEFYCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q5IRC3_NEMVE/41-354 + 0.14035 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IRC3 + Protein Wnt + NCDEIGQLS--NHRQVQVCKRNIQ--------VMDSVKDGASVALFECQHQFRYRPWNCTTVQFSR-------------------------------SPVFGN-SINGG--TREAAFVHAISSAGVAYAVTQACSSGRLGQKCGCDRKT--------------------RGQADG-----------------------------------------------------------------------FNWGGCSDDI-DFGMTFATRFVDARERG----SGIGSPARVL--MNLHNNRGGRLAVRKFMDLQCKCH---GVSGSCNIKT--------------------CWR-ALPNFRIVGDYIKEKFDG-ATEVEYKLIGGKHVLVPK--------------------------------------------------------------------------------------------NRKYK----PH----------TQMDLVYLVQSPDFCEPNPKT-GSLGTQGRIC-------------NRT-SQ---------AIDG-CDLMC--CGRGYVSRTEVRQE-QCACK-FF-----WCCHVRCQTCMRRVEVSYCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.01201 + 66 + + 0.05249 + 100 + + 20 + 71 + 142 + + + 7711 + Chordata + phylum + + + 0.05276 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.02534 + 99 + + 20 + 71 + 142 + + + WNT11_DANRE/43-354 + 0.07896 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + O73864 + Protein Wnt-11 + wnt11 + HCKLLDGLV---PDQQQLCKRNLE--------LMHSIVRAARLTKSACTSSFSDMRWNWSSIESA---------------------------------PHFTP-DLAKG--TREAAFVVSLAAAVVSHAIARACASGDL-PSCSCAAMP--------------------SEQAAPD----------------------------------------------------------------------FRWGGCGDNLRYYGLQMGSAFSDAPMRN----RRSGPQDFRL--MQLHNNAVGRQVLMDSLEMKCKCH---GVSGSCSVKT--------------------CWK-GLQDISTISADLKSKYLS-ATKVIPRQIGTRRQLVPR--------------------------------------------------------------------------------------------EMEVR----PV----------GENELVYLVSSPDYCTQNAKQ-GSLGTTDRQC-------------NKT-AS---------GSES-CGLMC--CGRGYNAYTEVLVE-RCQCK-YH-----WCCYVSCKTCKRTVERYVSK + + establishment of mitotic spindle orientation + + + gastrulation with mouth forming second + + + neural plate morphogenesis + + + heart looping + + + Ras GTPase activator activity + + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + cytoplasm + + + plasma membrane + + + protein phosphorylation + + + central nervous system development + + + heart development + + + mesodermal cell migration + + + protein localization + + + positive regulation of gene expression + + + single organismal cell-cell adhesion + + + cell migration + + + regulation of endocytosis + + + neuron differentiation + + + protein kinase activator activity + + + negative regulation of cell growth + + + positive regulation of cell migration + + + negative regulation of cell migration + + + positive regulation of Ras GTPase activity + + + protein localization to cell surface + + + non-canonical Wnt signaling pathway + + + cell migration involved in gastrulation + + + camera-type eye development + + + negative regulation of apoptotic process + + + transcription regulatory region DNA binding + + + regulation of protein kinase activity + + + positive regulation of protein kinase activity + + + negative regulation of transcription, DNA-templated + + + positive regulation of transcription, DNA-templated + + + embryonic eye morphogenesis + + + positive regulation of stress fiber assembly + + + palate development + + + convergent extension + + + convergent extension involved in gastrulation + + + convergent extension involved in axis elongation + + + mediolateral intercalation + + + negative regulation of cell death + + + eye field cell fate commitment involved in camera-type eye formation + + + neuroendocrine cell differentiation + + + Kupffer's vesicle development + + + positive regulation of protein kinase C signaling + + + negative regulation of canonical Wnt signaling pathway + + + + + WN11B_XENLA/42-353 + 0.06668 + + 20 + 71 + 142 + + + 8355 + XENLA + Xenopus laevis + African clawed frog + species + + + XWnt-11 + P49893 + Protein Wnt-11b + wnt11b + HCRLLDGLV---PDQSQLCKRNLE--------LMQSVVNAAKQTKLTCQMTLSDMRWNCSSVENA---------------------------------PSFTP-DLSKG--TRESAFVYALASATLSHTIARACASGEL-PTCSCGATP--------------------AEVPGTG----------------------------------------------------------------------FRWGGCGDNL-HYGLNMGSAFVDAPMKS---SKSAGTQATKI--MNLHNNAVGRQVLMDSLETKCKCH---GVSGSCSVKT--------------------CWK-GLQDLPHIANELKSKYLG-ATKVIHRQTGTRRQLVPR--------------------------------------------------------------------------------------------ELDIR----PV----------RESELVYLVSSPDYCTKNPKL-GSYGTQDRLC-------------NKT-SV---------GSDS-CNLMC--CGRGYNAYTETIVE-RCQCK-YH-----WCCYVMCKKCERTVERYVCK + + neural crest cell migration + + + Ras GTPase activator activity + + + frizzled binding + + + protein binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + cytoplasm + + + plasma membrane + + + protein phosphorylation + + + endocytosis + + + heart development + + + dorsal/ventral axis specification + + + positive regulation of gene expression + + + Wnt signaling pathway + + + Wnt-protein binding + + + growth factor binding + + + protein kinase activator activity + + + negative regulation of cell growth + + + positive regulation of cell migration + + + negative regulation of cell migration + + + positive regulation of Ras GTPase activity + + + protein localization to cell surface + + + non-canonical Wnt signaling pathway + + + cell migration involved in gastrulation + + + protein homodimerization activity + + + negative regulation of apoptotic process + + + protein complex + + + transcription regulatory region DNA binding + + + positive regulation of protein kinase activity + + + negative regulation of transcription, DNA-templated + + + positive regulation of transcription, DNA-templated + + + positive regulation of JNK cascade + + + pronephros development + + + positive regulation of stress fiber assembly + + + palate development + + + convergent extension involved in gastrulation + + + canonical Wnt signaling pathway + + + Wnt signaling pathway, planar cell polarity pathway + + + negative regulation of cell death + + + heart formation + + + neuroendocrine cell differentiation + + + positive regulation of protein kinase C signaling + + + negative regulation of canonical Wnt signaling pathway + + + 399441 + xla:399441 + + + + + + Q9I9I2_DANRE/42-352 + 0.09097 + + 20 + 71 + 142 + + + 7955 + DANRE + Danio rerio + Zebrafish + Brachydanio rerio + species + + + Q9I9I2 + Protein Wnt + wnt11r + HCKTLPGLV---SSQAQLCRSNLE--------LMQTIIQAAREVKKVCQKTFTDMRWNCSSIDG----------------------------------PKFLP-DLERG--TRESAFVYALSAAAISHTIARACTSGDL-RLCSCGPIP--------------------GEIPEPG----------------------------------------------------------------------YRWGGCADNI-HYGLLMGSKFSDAPMKM---KKKSGSHANKL--MHLHNSEVGRQALRDALVMKCKCH---GVSGSCSIRT--------------------CWR-GLLDLKDIAIDLKTKYLS-ATKVVHRPMGTRKQLVPK--------------------------------------------------------------------------------------------DIDIR----PV----------RENELVYLQSSPDYCMKNDKL-GSFGTQDRQC-------------NKT-SS---------GSDS-CDLMC--CGRGYNPYTERVVE-RCHCK-YH-----WCCYVTCKKCDKTVEKYVCK + + heart looping + + + frizzled binding + + + proteinaceous extracellular matrix + + + extracellular space + + + heart development + + + Wnt signaling pathway + + + neuron differentiation + + + cell migration involved in gastrulation + + + cell fate commitment + + + 30283 + dre:30283 + 20806727 + + + + + + Q9NCQ1_BRAFL/42-351 + 0.13473 + + 20 + 71 + 142 + + + 7739 + BRAFL + Branchiostoma floridae + Florida lancelet + Amphioxus + species + + + Q9NCQ1 + Protein Wnt + Wnt11 + SCRKVSGFV---PEQTQLCRRTLE--------VMPAVEYAAESARKTCQEQFGNRRWNCSSIKKA---------------------------------PHFMN-DLEKG--TKEAAYVHALSSAAVVHTVARACAAGYL-KACTCARNP--------------------GEKPDGN----------------------------------------------------------------------YTWGGCGDNV-KFGLEFGSRFADAPMR-----KKKRSHTQTL--MNLHNSEAGRLAVQNTMTTKCKCH---GVSGSCNVKT--------------------CWK-SLADLTEISHELAEKYSY-AIKVVKRKIGTRQQLVPE--------------------------------------------------------------------------------------------DRRSR----RH----------GSGDLIFVENSPNYCMVNNRK-GSYGTTGRLC-------------NKT-SV---------GPDS-CQTMC--CGRGYNDFTVTVTE-RCNCK-YH-----WCCYVTCDQCTRTEKKYMCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q5IRC2_NEMVE/39-352 + 0.2089 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5IRC2 + Protein Wnt + DCNRIHGFS---GKQYKICRRNLP--------AMLYVTAAVEMTREECQHQFQNKRWNCSTIV--K-------------------------------APQFLP-DLKRG--TPEAAFVYALSAAALTYSITQACGMKRL-KPCKCGTNP--------------------KFKHPD-----------------------------------------------------------------------GEWGGCHDNI-ARGMRFSKDFTDAVEAQR--MRKHKSMAVAL--MNLHNNGVGRKAVHSRLEFHCRCH---GVSGGCTAKT--------------------CIR-RLGDFRLVADLLKNRYAR-IVYVESKTKSKRKAR-----------------------------------------------------------------------------------------------VLKSKRGRRRY----------TSSDLVALQGSPNYCHKNRKR-GTAGTHGRLC-------------DPT-KR---------RGEGSCAYLC--CGRGHRTEEVVHEE-RCECK-YI-----WCCYVKCQTCRKRVRESRCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + + + Q5TS73_ANOGA/68-376 + 0.22168 + + 0 + 173 + 193 + + + 7165 + ANOGA + Anopheles gambiae + African malaria mosquito + species + + + Q5TS73 + Protein Wnt + LCGDTAFFT---EHQRDTCYSNPE--------LLKVIVHAANTAKYECQSYFQNNRWNCSAKRGS---------------------------------GIYYGNFDDKG--NRETAYLSAINSASLAWTITRFCTKGEL-TTCQCDRIP--------------------RNKHSTK----------------------------------------------------------------------WTWGGCSEDI-KYGIKQARSFTDPQE--------NRTTSFGL--MNLHNNEAARRILRSRMEKVCKCH---GMSGSCTTRV--------------------CWR-RLPPMKLIADTLGSLFDA-AAQVKPVENKGIIRKLMR-------------------------------------------------------------------------------------------KDLEYKK--V------------NKSDLVYIAESPNYCEENESL-GIFSTRGRFC-------------NRT-SY---------GIEG-CRLLC--CGRGYQTRIRNVEE-KCNCK-FV-----WCCSVKCDTCSMRKDEHICN + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.0143 + 71 + + 0.00663 + 49 + + A1DYI3_CHICK/44-355 + 0.15137 + + 20 + 71 + 142 + + + 9031 + CHICK + Gallus gallus + Chicken + species + + + A1DYI3 + Protein Wnt + Wnt3 + LCGSIPGLV---PKQLRFCRNYIE--------IMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDS--------------------------------LAIFGP-VLDKA--TRESAFVHAIASAGVAFAVTRSCAEGTS-TICGCDSHH--------------------KGPPGEG----------------------------------------------------------------------WKWGGCSEDA-DFGVLVSREFADARE--------NRPDARSA--MNRHNNEAGRTTILDHMHLKCKCH---GLSGSCEVKT--------------------CWW-AQPDFRAIGDYLKDKYDS-ASEMVVEKHRESRGWVETL---------------------------------------------------------------------RA-------------------KYALFK----PP----------TERDLVYYENSPNFCEPNPET-GSFGTRDRTC-------------NVT-SH---------GIDG-CDLLC--CGRGHNTRTEKRKE-KCHCI-FH-----WCCYVSCQECIRVYDVHTCK + + mesoderm formation + + + proteinaceous extracellular matrix + + + axon guidance + + + anterior/posterior axis specification + + + dorsal/ventral axis specification + + + positive regulation of gene expression + + + embryonic forelimb morphogenesis + + + embryonic hindlimb morphogenesis + + + canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation + + + canonical Wnt signaling pathway involved in osteoblast differentiation + + + positive regulation of collateral sprouting in absence of injury + + + negative regulation of axon extension involved in axon guidance + + + Spemann organizer formation at the anterior end of the primitive streak + + + limb bud formation + + + head morphogenesis + + + mammary gland epithelium development + + + 7473 + gga:374142 + 20813657 + + + + + Q9GTJ9_HYDVU/47-363 + 0.19186 + + 20 + 132 + 81 + + + 6087 + HYDVU + Hydra vulgaris + Hydra + Hydra attenuata + species + + + Q9GTJ9 + Protein Wnt + WNT3 + LCRALYLHH----YQRTVCLNYTD--------LMLSVAEGIRLGIDECQVQFKHRKWNCTINEHG--------------------------------TSVFGP-IITTA--SRESAFISGIISAGVAFSVTESCAEGKS-VHCRCDNSV--------------------RGQTDEG----------------------------------------------------------------------WRWGGCNRPI-TYGIWFSQLFIDQVEKI----VKKRKDPRKI--MNLHNNKAGREVIKNLLQTECKCH---GTSGNCNLKT--------------------CWR-SQPHFSEIGKILKEKYDS-AHEMEFLYKVKANGERKIK----------------------------------------------------------------------D-------------------LIPKYKE-YLPP----------SSLDFIYYEESPNYCVKNETL-GIAGTKGRSC-------------NIT-SS---------GVDG-CELMC--CQRGYNVNIVQKTH-SCECK-FV-----WCCKVSCNSCIKMTPEYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + hmg:100203050 + + + + + + A7RXF5_NEMVE/41-349 + 0.16164 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + A7RXF5 + Protein Wnt + LCYVTRQFN---SRQQEVCRKNPD--------LMEHVAHGAKYGVHECRHQFRNRRWNCSTIRES--------------------------------GSLFES-VLSKG--CREAAFVHAVTAAGVAHSVTDACSKGRI-ESCDCDRNL--------------------SGRSSKG----------------------------------------------------------------------WTWSGCNSNI-KFGVWFSKQFTEARE--------RGGDLRQI--MNRHNSRAGRKALEELVWRKCKCH---GLSGSCSMKT--------------------CWM-QQANFRQIGDHLKVKYDS-AVEMTTKVNRRGKKRLKP-------------------------------------------------------------------------------------------KYSHFK----KP----------SDKDLIYFETSPNYCDKNVTV-GSLGTSGRQC-------------NYT-SN---------GIDG-CELLC--CGRGHNIQQAKITR-NCNCV-FK-----WCCEVKCERCKEVVNIYTCK + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + 0.014705 + 99 + + 0.02456 + 100 + + 0.01307 + 90 + + 0.00711 + 58 + + 0.00898 + 51 + + 0.08224 + 100 + + 0 + 173 + 193 + + + 33340 + Neoptera + subclass + + + 0.03803 + 98 + + 0 + 173 + 193 + + + 33392 + Endopterygota + infraclass + + + 0.14138 + 100 + + 0 + 173 + 193 + + + 7147 + Diptera + order + + + Q16S09_AEDAE/31-428 + 0.09724 + + 0 + 173 + 193 + + + 7159 + AEDAE + Aedes aegypti + Yellowfever mosquito + Culex aegypti + species + + + Q16S09 + Protein Wnt + MDPAIHATL--RRKQRRLARENPG--------VLAAIAKGANMAINECQHQFRNRRWNCSTRNFLR------------------------------GKNLFGK-IVERG--CRETAFIYAITSAAVTHSIARACSEGSI-ESCTCDYSHQSRAP---------QASTMGAVAGVRD----------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE--------RGRTLREK--MNLHNNEAGRAHVQSEMRQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRVVGDLLKDRFDG-ASRVMVSNSLRTSVNEA-TLSNRANPNGLKAQNQLGGSSPGGPNSV---------------SSNSIHARSHQQKKINRSFGDFQRWTKFLSKIFEFPSSINRYNFQLKPHNPDHK----PP----------GTKDLVYLEPSPGFCDRNPRL-GIQGTHGRQC-------------NDT-SI---------GVDG-CDLMC--CGRGYRTQEVIVVE-RCACT-FH-----WCCEVKCKLCRTKKIIHTCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + WNTG_DROME/56-468 + 0.23847 + + 0 + 173 + 193 + + + 7227 + DROME + Drosophila melanogaster + Fruit fly + species + + + P09615 + Protein wingless + wg + MDPAIHSTL--RRKQRRLVRDNPG--------VLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLF--------------------GKIVDRG-------------CRETSFIYAITSAAVTHSIARACSEGTI-ESCTCDYSHQSRSP---------QANHQAGSVAGVRD---------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE----------RGRNLREKMNLHNNEAGRAHVQAEMRQECKCH---GMSGSCTVKT--------------------CWM-RLANFRVIGDNLKARFDG-ATRVQVTNSLR-ATNAL-APVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHK----PP----------GSKDLVYLEPSPSFCEKNLRQ-GILGTHGRQC-------------NET-SL---------GVDG-CGLMC--CGRGYRRDEVVVVE-RCACTFH------WCCEVKCKLCRTKKVIYTCL + + compound eye morphogenesis + + + instar larval development + + + negative regulation of heart induction by canonical Wnt signaling pathway + + + frizzled binding + + + frizzled-2 binding + + + Notch binding + + + protein binding + + + glycosaminoglycan binding + + + extracellular region + + + proteinaceous extracellular matrix + + + extracellular space + + + multivesicular body + + + endoplasmic reticulum + + + plasma membrane + + + regulation of transcription, DNA-templated + + + Wnt signaling pathway, calcium modulating pathway + + + regulation of mitotic cell cycle + + + segment polarity determination + + + dorsal closure + + + dorsal closure, elongation of leading edge cells + + + ectoderm development + + + ventral midline development + + + ventral cord development + + + sensory organ development + + + hindgut morphogenesis + + + imaginal disc development + + + imaginal disc growth + + + imaginal disc pattern formation + + + anterior/posterior pattern specification, imaginal disc + + + dorsal/ventral pattern formation, imaginal disc + + + imaginal disc-derived wing morphogenesis + + + leg disc proximal/distal pattern formation + + + mesoderm development + + + heart development + + + larval visceral muscle development + + + long-term memory + + + positive regulation of cell proliferation + + + epidermis development + + + anterior/posterior axis specification, embryo + + + cell surface + + + negative regulation of cell fate specification + + + cardioblast differentiation + + + neuroblast development + + + morphogen activity + + + cytoplasmic membrane-bounded vesicle + + + ommatidial rotation + + + lamellipodium assembly + + + cell junction + + + endocytic vesicle + + + neuron differentiation + + + ovarian follicle cell development + + + negative regulation of DNA endoreduplication + + + cuticle pattern formation + + + branch fusion, open tracheal system + + + epithelial cell type specification, open tracheal system + + + larval lymph gland hemopoiesis + + + lymph gland crystal cell differentiation + + + genital disc development + + + labial disc development + + + wing disc development + + + genital disc anterior/posterior pattern formation + + + determination of genital disc primordium + + + genital disc sexually dimorphic development + + + spiracle morphogenesis, open tracheal system + + + anterior head segmentation + + + posterior head segmentation + + + trunk segmentation + + + wing cell fate specification + + + regulation of cell proliferation + + + positive regulation of crystal cell differentiation + + + negative regulation of apoptotic process + + + regulation of imaginal disc-derived wing size + + + membrane raft + + + synapse + + + negative regulation of hemocyte differentiation + + + negative regulation of transcription, DNA-templated + + + positive regulation of compound eye retinal cell programmed cell death + + + filopodium assembly + + + regulation of compound eye pigmentation + + + wing disc dorsal/ventral pattern formation + + + mesoderm morphogenesis + + + lymph gland development + + + proboscis development + + + compound eye development + + + branching morphogenesis of an epithelial tube + + + extracellular matrix binding + + + actin filament bundle assembly + + + Spemann organizer formation + + + canonical Wnt signaling pathway + + + heart formation + + + pericardial nephrocyte differentiation + + + posterior Malpighian tubule development + + + epithelial cell proliferation involved in Malpighian tubule morphogenesis + + + Malpighian tubule bud morphogenesis + + + Malpighian tubule tip cell differentiation + + + regulation of stem cell proliferation + + + 474168 + 786411 + + + + + + WNT1_BOMMO/57-392 + 0.0606 + + 0 + 173 + 193 + + + 7091 + BOMMO + Bombyx mori + Silk moth + species + + + P49340 + Protein Wnt-1 + WNT-1 + VHATL------RRKQRRLARENPG--------VLAAVAK-AQYAFAECQHQFKYRRWNCSTRNFLR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHSLARACREASI-ESCTCDYSHRPRAA---------QNPVGGRANVRV-----------------------------------------------------------------------WKWGGCSDNI-GFGFRFSREFVDTGE--------RGKTLREK--MNLHNNEAGRRHVQTEMKQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRSVGDSLKDRFDG-ASRVMLSKADVETPAQR-NEAAPHR---------------------------------------------------------VPRKDRYR-FQL-------------RPHNPDHK----SP----------GVKDLVYLESSPGFCEKNPRL-GIPGTHGRAC-------------NDT-SI---------GVDG-CDLMC--CGRGYKTNTMFVVE-RCNCT-FH-----WCCEVKCKLCRTEKVVHTCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + 692745 + bmor:692745 + + + + + + Q9GRA6_GRYBI/62-394 + 0.07433 + + 0 + 173 + 193 + + + 6999 + GRYBI + Gryllus bimaculatus + Two-spotted cricket + species + + + Q9GRA6 + Protein Wnt + wg + VHATL------RRKQRRLVRDHPG--------VLLAVVKGANQAIGECQFQFRNRRWNCSTKNFFR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHAIARACAEGSI-QSCTCDYRHAGRVA---------GGRGGGGGGGKKPD---------------------------------------------------------------------WEWGGCSDNI-EYGFKFSRDFVDTGE--------RGRTLREK--MNLHNNEAGRLHVREEMRKECKCH---GMSGSCTVKT--------------------CWM-RLPHFRVVGDNLKDRFDG-ASRVLVGNAGSPRGPGA-GKGKG-------------------------------------------------------------NRYNFQ-LQ---------------PYDAQHK----PP----------GRKDLVYLDQSPNFCERNPRQ-GIQGTHGREC-------------NET-SL---------GLDG-CDLMC--CGRGHRSQEVMLVE-RCHCT-FH-----WCCEVKCKTCHVRKTIHTCQ + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.0145 + 81 + + 0 + 132 + 132 + + + 6340 + Annelida + phylum + + + Q2QJF8_9ANNE/61-379 + 0.14789 + + 0 + 132 + 132 + + + 283909 + 9ANNE + Capitella teleta + phylum + + + Q2QJF8 + Protein Wnt + wg + INPSLQPLT---RKQRRLVTRNPG--------TSIAIAKAARMAVDECQRQFSTRRWNCPVYDASH------------------------------GSSIFGK-VVRKG--IRECAFIYAIMSAALAHSIARSCAEGSI-YTCTCGRHSRRLAN---------SVQPRD-----------------------------------------------------------------------------WEWGGCSDNA-EFGRKFSHDFIDVAE--------KGRDLKCL--MNLHNSEAGRTQVSSEMSKECKCH---GMSGSCTVKT--------------------CWM-KLPMFGRVGKVVKDRFDG-ASQVEQGNGAINRSKNR-FN--------------------------------------------------------------------LI-P-----------------INTNHK----PP----------EPKDLVYFERSPTFCTKDPSI-GHTGTHGRPC-------------NAS-SI---------GVEG-CDLLC--CGRGYRSELYTARE-RCNCI-FH-----WCCKVTCDTCTKTKVRHICL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + Q8MPL8_PLADU/57-388 + 0.14646 + + 0 + 132 + 132 + + + 6359 + PLADU + Platynereis dumerilii + Dumeril's clam worm + species + + + Q8MPL8 + Protein Wnt + wnt1 + INPSLQPLT---RKQRRVVTRNPG--------TIVAVAKGARVAIHECQFQFRNRRWNCPTTEDGR------------------------------GGSIFGDIFKAAG--TRETAFIYAVTAAGVTHSVARACSEGSI-FTCSCGRRR--------------------RIDVTSSLPTSAAS---------------------------------------------------------IPPAATWEWGGCSDNI-EFGQRFSREFVDLVE--------KGRDLRYM--MNLHNNQAGRIHVVSEQHQECKCH---GMSGSCTVKT--------------------CWM-RLAPFRQTGARLKDRFDG-APRVYQGNSGNSRNRNRLQKF-----------------------------------------------------------------NLLPV-------------------NPNHK----SP----------GPQDLVYFEESPTFCDENRTL-GLQGTTGRQC-------------NVS-SI---------GVDG-CDLMC--CGRGWVEETYLSKE-RCNCT-FH-----WCGQVTCHICNRTRVRHLCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + Q8T396_CUPSA/63-374 + 0.11699 + + 0 + 173 + 193 + + + 6928 + CUPSA + Cupiennius salei + Wandering spider + species + + + Q8T396 + Protein Wnt + wg + PAPHLPLRK----KQRRLVRDNPG--------AMQAIGRGVKVAISECKYQFKKRRWNCPTADHAR------------------------------GKNIFGK-IVQRG--CRETAFLYAITSAGVTHSLSRACREGLV-STCNCDYRR--------------------RGPSGLH----------------------------------------------------------------------WEWGGCSDNI-DFGAKFSRQFVDASE--------RGKDLRYI--MNLHNNEAGRAHVIGGMRRQCKCH---GMSGSCTVQT--------------------CWM-QLSPFRTIGDGLKDRFDG-ASRVLVTNRGNVRRRAL-L---------------------------------------------------------------------KP-------------------YHPEHK----PP----------SKKDLVYFENSPDFCYADPSL-GHSATLGRTC-------------NVS-SL---------GVDG-CDLMC--CGRGYKSENREEVS-RCNCT-FH-----WCCQVECKTCKTKRLVHECL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + 0.06569 + 100 + + 20 + 71 + 142 + + + 117571 + Euteleostomi + + + 0.00506 + 55 + + 20 + 71 + 142 + + + Q3UR96_MOUSE/57-370 + 0.06041 + + 20 + 71 + 142 + + + 10090 + MOUSE + Mus musculus + Mouse + species + + + Q3UR96 + Protein Wnt + Wnt1 + LEPSLQLLS---RKQRRLIRQNPG--------ILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP---------------------------------HLFGK-IVNRG--CRETAFIFAITSAGVTHSVARSCSEGSI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-DFGRLFGREFVDSGE--------KGRDLRFL--MNLHNNEAGRTTVFSEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPTLRAVGDVLRDRFDG-ASRVLYGNRGSNRAS---RAE-----------------------------------------------------------------LLRL-E----------------PEDPAHK----PP----------SPHDLVYFEKSPNFCTYSGRL-GTAGTAGRAC-------------NSS-SP---------ALDG-CELLC--CGRGHRTRTQRVTE-RCNCT-FH-----WCCHVSCRNCTHTRVLHECL + + branching involved in ureteric bud morphogenesis + + + positive regulation of protein phosphorylation + + + receptor binding + + + frizzled binding + + + protein binding + + + proteinaceous extracellular matrix + + + extracellular space + + + cytoplasm + + + signal transduction + + + cell-cell signaling + + + myoblast fusion + + + positive regulation of cell proliferation + + + response to wounding + + + organ morphogenesis + + + cell surface + + + positive regulation of lamellipodium assembly + + + negative regulation of cell-substrate adhesion + + + myotube differentiation + + + Wnt signaling pathway + + + spinal cord association neuron differentiation + + + diencephalon development + + + forebrain anterior/posterior pattern specification + + + midbrain-hindbrain boundary maturation during brain development + + + metencephalon development + + + negative regulation of cell-cell adhesion + + + BMP signaling pathway + + + negative regulation of transforming growth factor beta receptor signaling pathway + + + negative regulation of BMP signaling pathway + + + ubiquitin-dependent SMAD protein catabolic process + + + midbrain development + + + midbrain-hindbrain boundary development + + + organ regeneration + + + T cell differentiation in thymus + + + inner ear morphogenesis + + + signal transduction in response to DNA damage + + + positive regulation of insulin-like growth factor receptor signaling pathway + + + transcription regulatory region DNA binding + + + canonical Wnt signaling pathway involved in negative regulation of apoptotic process + + + negative regulation of fat cell differentiation + + + positive regulation of Notch signaling pathway + + + positive regulation of transcription, DNA-templated + + + positive regulation of transcription from RNA polymerase II promoter + + + positive regulation of fibroblast proliferation + + + neuron fate commitment + + + neuron fate determination + + + canonical Wnt signaling pathway + + + bone development + + + positive regulation of dermatome development + + + hepatocyte differentiation + + + cellular response to peptide hormone stimulus + + + hematopoietic stem cell proliferation + + + negative regulation of cell aging + + + negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process + + + 7471 + mmu:22408 + 302801 + + + + + Q4TCL8_TETNG/22-336 + 0.05449 + + 20 + 71 + 142 + + + 99883 + TETNG + Tetraodon nigroviridis + Spotted green pufferfish + Chelonodon nigroviridis + species + + + Q4TCL8 + Protein Wnt + LDPSLALLS---RRQRRLIRQNPG--------ILHAIAAGLHAAIKECKWQFRNRRWNCPTTHSP---------------------------------AVFGK-IVNRG--CRETAFVFAITSAGVTHAVARSCSEGAI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNV-EFGRMFTREFVDSSE--------RGRDLRYL--TNLHNNEAGRMTVSTEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPSFRTVGDFLKDRFDG-ASRVVYANKGSNRASH--KAN-----------------------------------------------------------------PRHL-E----------------PENPAHK----SP----------SSMDLVYFEKSPNFCSYSGKT-GTLGTSGRMC-------------NST-SP---------GLDG-CELLC--CGRGFKTRTETVTE-RCHCT-FH-----WCCHVSCLNCTSTRTLHQCV + + proteinaceous extracellular matrix + + + Wnt signaling pathway + + + cerebellum morphogenesis + + + fourth ventricle development + + + midbrain-hindbrain boundary development + + + brain segmentation + + + + + + WNT1_XENLA/58-371 + 0.0706 + + 20 + 71 + 142 + + + 8355 + XENLA + Xenopus laevis + African clawed frog + species + + + XWnt-1 + P10108 + Protein Wnt-1 + wnt1 + LDPSLQLLS----RQKRLIRQNPG--------ILQSITRGLHSAIRECKWHFRNRRWNCPTGTGN---------------------------------QVFGK-IINRG--CRETAFVFAITSAGVTHSVARSCSEGSI-ESCSCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-EFGRFIGREFVDSSE--------RGRDLKYL--VNLHNNQAGRLTVLTEMRQECKCH---GMSGSCSLRT--------------------CWM-RLPPFRSVGDALKDRFDG-ASKVTYSNNGSNRWGS--RSD-----------------------------------------------------------------PPHL-E----------------PENPTHA----LP----------SSQDLVYFEKSPNFCSPSEKN-GTPGTTGRIC-------------NST-SL---------GLDG-CELLC--CGRGYRSLAEKVTE-RCHCT-FN-----WCCHVTCLNCTSSQIVHECL + + proteinaceous extracellular matrix + + + neural crest cell fate specification + + + Wnt signaling pathway + + + forebrain anterior/posterior pattern specification + + + negative regulation of transcription, DNA-templated + + + 7471 + xla:373578 + + + + + + + O61699_BRAFL/59-377 + 0.15398 + + 20 + 71 + 142 + + + 7739 + BRAFL + Branchiostoma floridae + Florida lancelet + Amphioxus + species + + + O61699 + Protein Wnt + Wnt1 + LDPKKHPLN---KKQRRLVRRNPG-------DAGEHRDRRPMLAIKECHHQFSKWRWNCPVNTSDH------------------------------VNSVFGN-ILLRG--CTQTAFIYAVMSAAVAHEVGRNCAEGTI-ETCSCDYRS--------------------KGPAGED----------------------------------------------------------------------WEWGGCSDNV-EFGKQFAKQFVDAGE-------KTKDSVRYL--VNMHNNEAGRVAVAENLRRECKCH---GMSGSCTLKT--------------------CWM-RLPNFRDVGDSLKEKFDG-ASKVAFPDIGNNRGSRAKVT-------------------------------------------------------------------GLV-P-----------------KNSRHK----FP----------TDNDLVYHERSPNFCRNNPRL-GFEGTRGREC-------------NVT-SR---------GLDG-CDLLC--CGRGYATRQEVTKE-RCNCT-FQ-----WCCQVKCEECVRTKTIHTCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + Q5J2D4_NEMVE/46-364 + 0.17152 + + 20 + 132 + 81 + + + 45351 + NEMVE + Nematostella vectensis + Starlet sea anemone + species + + + Q5J2D4 + Protein Wnt + PPNQIRALT---QKQIRISRRYPE--------LIQYIAGGARTAIHECQHQFRNRKWNCSAHSPE---------------------------------NVFGK-ILKRA--CRETAFTYAITAAGVSHAIARACGEGKL-SACSCDQRY--------------------RGVSKQG----------------------------------------------------------------------WQWGGCSDNI-HFADNFSKRFVDAQE--------KGRDFRAQ--INLHNNEAGRAAVRNNMMLECKCH---GLSEACTVKT--------------------CWK-RLPDFRLVGDDLKAKFDD-ASMVEYQQNNNNRNSNRNRN-------------------------------------------------------------------EDP-A-----------------LFIPSKPYLRRP----------TVYDLGYYEHSPNFCERNPSA-GSLGTQGREC-------------NTT-SM---------GTDG-CELMC--CGRGFTTSSQERVE-NCNCRVFL-----GGCEVKCQKCKHEGSLSNCL + + proteinaceous extracellular matrix + + + multicellular organismal development + + + Wnt signaling pathway + + + + + + + \ No newline at end of file -- 1.7.10.2