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-<head>
-<title>Colouring by Conservation</title>
-</head>
-<body>
- <p>
- <strong>Colouring by Conservation</strong>
- </p>
- <p>
- This is an approach to alignment colouring which highlights regions
- of an alignment where physicochemical properties are conserved. It
- is based on the one used in the AMAS method of multiple sequence
- alignment analysis (Livingstone C.D. and Barton G.J. (1993), Protein
- Sequence Alignments: A Strategy for the Hierarchical Analysis of
- Residue Conservation.CABIOS Vol. 9 No. 6 (745-756)). See the <a
- href="../calculations/conservation.html">conservation
- calculation</a> help page for a more thorough explanation of the
- calculation.
- </p>
- <p>For an already coloured alignment, the conservation index at
- each alignment position is used to modify the shading intensity of
- the colour at that position. This means that the most conserved
- columns in each group have the most intense colours, and the least
- conserved are the palest. The slider controls the contrast between
- these extremes.</p>
- <p>
- Conservation can be calculated over all sequences in an alignment,
- or just within specific groups (such as those defined by <a
- href="../calculations/tree.html">phylogenetic tree
- partitioning</a>). The option 'apply to all groups' controls whether
- the contrast slider value will be applied to the indices for the
- currently selected group, or all groups defined over the alignment.
- </p>
-</body>
-</html>