+++ /dev/null
-/*
- * Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
- * Copyright (C) $$Year-Rel$$ The Jalview Authors
- *
- * This file is part of Jalview.
- *
- * Jalview is free software: you can redistribute it and/or
- * modify it under the terms of the GNU General Public License
- * as published by the Free Software Foundation, either version 3
- * of the License, or (at your option) any later version.
- *
- * Jalview is distributed in the hope that it will be useful, but
- * WITHOUT ANY WARRANTY; without even the implied warranty
- * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
- * PURPOSE. See the GNU General Public License for more details.
- *
- * You should have received a copy of the GNU General Public License
- * along with Jalview. If not, see <http://www.gnu.org/licenses/>.
- * The Jalview Authors are detailed in the 'AUTHORS' file.
- */
-package jalview.datamodel.xdb.embl;
-
-import static org.testng.AssertJUnit.assertEquals;
-import static org.testng.AssertJUnit.assertNull;
-import static org.testng.AssertJUnit.assertSame;
-
-import jalview.analysis.SequenceIdMatcher;
-import jalview.datamodel.DBRefEntry;
-import jalview.datamodel.DBRefSource;
-import jalview.datamodel.SequenceI;
-import jalview.gui.JvOptionPane;
-import jalview.util.MapList;
-
-import java.util.ArrayList;
-import java.util.Arrays;
-import java.util.List;
-
-import org.testng.annotations.BeforeClass;
-import org.testng.annotations.Test;
-
-public class EmblEntryTest
-{
-
- @BeforeClass(alwaysRun = true)
- public void setUpJvOptionPane()
- {
- JvOptionPane.setInteractiveMode(false);
- JvOptionPane.setMockResponse(JvOptionPane.CANCEL_OPTION);
- }
-
- @Test(groups = "Functional")
- public void testGetCdsRanges()
- {
- EmblEntry testee = new EmblEntry();
-
- /*
- * Make a (CDS) Feature with 5 locations
- */
- EmblFeature cds = new EmblFeature();
- cds.setLocation("join(10..20,complement(30..40),50..60,70..80,complement(110..120))");
-
- int[] exons = testee.getCdsRanges(cds);
- assertEquals("[10, 20, 40, 30, 50, 60, 70, 80, 120, 110]",
- Arrays.toString(exons));
- }
-
- @Test(groups = "Functional")
- public void testParseCodingFeature()
- {
- // not the whole sequence but enough for this test...
- List<SequenceI> peptides = new ArrayList<SequenceI>();
- SequenceIdMatcher matcher = new SequenceIdMatcher(peptides);
- EmblFile ef = EmblTestHelper.getEmblFile();
- assertEquals(1, ef.getEntries().size());
- EmblEntry testee = ef.getEntries().get(0);
- String sourceDb = "EMBL";
- SequenceI dna = testee.makeSequence(sourceDb);
-
- /*
- * parse three CDS features, with two/one/no Uniprot cross-refs
- */
- for (EmblFeature feature : ef.getEntries().get(0).getFeatures())
- {
- if ("CDS".equals(feature.getName()))
- {
- testee.parseCodingFeature(feature, sourceDb, dna, peptides, matcher);
- }
- }
-
- /*
- * peptides should now have five entries:
- * EMBL product and two Uniprot accessions for the first CDS / translation
- * EMBL product and one Uniprot accession for the second CDS / "
- * EMBL product only for the third
- */
- assertEquals(6, peptides.size());
- assertEquals("CAA30420.1", peptides.get(0).getName());
- assertEquals("MLCF", peptides.get(0).getSequenceAsString());
- assertEquals("UNIPROT|B0BCM4", peptides.get(1).getName());
- assertEquals("MLCF", peptides.get(1).getSequenceAsString());
- assertEquals("UNIPROT|P0CE20", peptides.get(2).getName());
- assertEquals("MLCF", peptides.get(2).getSequenceAsString());
- assertEquals("CAA30421.1", peptides.get(3).getName());
- assertEquals("MSSS", peptides.get(3).getSequenceAsString());
- assertEquals("UNIPROT|B0BCM3", peptides.get(4).getName());
- assertEquals("MSSS", peptides.get(4).getSequenceAsString());
- assertEquals("CAA12345.6", peptides.get(5).getName());
- assertEquals("MSS", peptides.get(5).getSequenceAsString());
-
- /*
- * verify dna sequence has dbrefs with CDS mappings to the peptide 'products'
- */
- MapList cds1Map = new MapList(new int[] { 57, 46 }, new int[] { 1, 4 },
- 3, 1);
- MapList cds2Map = new MapList(new int[] { 4, 15 }, new int[] { 1, 4 },
- 3, 1);
- MapList cds3Map = new MapList(new int[] { 4, 6, 10, 15 }, new int[] {
- 1, 3 }, 3, 1);
- DBRefEntry[] dbrefs = dna.getDBRefs();
- assertEquals(4, dbrefs.length);
- DBRefEntry dbRefEntry = dbrefs[0];
- assertEquals("UNIPROT", dbRefEntry.getSource());
- assertEquals("B0BCM4", dbRefEntry.getAccessionId());
- assertSame(peptides.get(1), dbRefEntry.getMap().getTo());
- assertEquals(cds1Map, dbRefEntry.getMap().getMap());
-
- dbRefEntry = dbrefs[1];
- assertEquals("UNIPROT", dbRefEntry.getSource());
- assertEquals("P0CE20", dbRefEntry.getAccessionId());
- assertSame(peptides.get(2), dbRefEntry.getMap().getTo());
- assertEquals(cds1Map, dbRefEntry.getMap().getMap());
-
- dbRefEntry = dbrefs[2];
- assertEquals("UNIPROT", dbRefEntry.getSource());
- assertEquals("B0BCM3", dbRefEntry.getAccessionId());
- assertSame(peptides.get(4), dbRefEntry.getMap().getTo());
- assertEquals(cds2Map, dbRefEntry.getMap().getMap());
-
- dbRefEntry = dbrefs[3];
- assertEquals("EMBLCDSPROTEIN", dbRefEntry.getSource());
- assertEquals("CAA12345.6", dbRefEntry.getAccessionId());
- assertSame(peptides.get(5), dbRefEntry.getMap().getTo());
- assertEquals(cds3Map, dbRefEntry.getMap().getMap());
-
- /*
- * verify peptides have dbrefs
- * - to EMBL sequence (with inverse 1:3 cds mapping)
- * - to EMBLCDS (with 1:3 mapping)
- * - direct (no mapping) to other protein accessions
- */
- MapList proteinToCdsMap1 = new MapList(new int[] { 1, 4 }, new int[] {
- 1, 12 }, 1, 3);
- MapList proteinToCdsMap2 = new MapList(new int[] { 1, 3 }, new int[] {
- 1, 9 }, 1, 3);
-
- // dbrefs for first CDS EMBL product CAA30420.1
- dbrefs = peptides.get(0).getDBRefs();
- assertEquals(5, dbrefs.length);
- assertEquals(DBRefSource.EMBL, dbrefs[0].getSource());
- assertEquals("CAA30420.1", dbrefs[0].getAccessionId());
- // TODO: verify getPrimaryDBRefs() for peptide products
- assertEquals(cds1Map.getInverse(), dbrefs[0].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDS, dbrefs[1].getSource());
- assertEquals("CAA30420.1", dbrefs[1].getAccessionId());
- assertEquals(proteinToCdsMap1, dbrefs[1].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDSProduct, dbrefs[2].getSource());
- assertEquals("CAA30420.1", dbrefs[2].getAccessionId());
- assertNull(dbrefs[2].getMap());
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "2.1", "B0BCM4"),
- dbrefs[3]);
- assertNull(dbrefs[3].getMap());
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "0", "P0CE20"),
- dbrefs[4]);
- assertNull(dbrefs[4].getMap());
-
- // dbrefs for first CDS first Uniprot xref
- dbrefs = peptides.get(1).getDBRefs();
- assertEquals(2, dbrefs.length);
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "2.1", "B0BCM4"),
- dbrefs[0]);
- assertNull(dbrefs[0].getMap());
- assertEquals(DBRefSource.EMBL, dbrefs[1].getSource());
- assertEquals("X07547", dbrefs[1].getAccessionId());
- assertEquals(cds1Map.getInverse(), dbrefs[1].getMap().getMap());
-
- // dbrefs for first CDS second Uniprot xref
- dbrefs = peptides.get(2).getDBRefs();
- assertEquals(2, dbrefs.length);
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "0", "P0CE20"),
- dbrefs[0]);
- assertNull(dbrefs[0].getMap());
- assertEquals(DBRefSource.EMBL, dbrefs[1].getSource());
- assertEquals("X07547", dbrefs[1].getAccessionId());
- assertEquals(cds1Map.getInverse(), dbrefs[1].getMap().getMap());
-
- // dbrefs for second CDS EMBL product CAA30421.1
- dbrefs = peptides.get(3).getDBRefs();
- assertEquals(4, dbrefs.length);
- assertEquals(DBRefSource.EMBL, dbrefs[0].getSource());
- assertEquals("CAA30421.1", dbrefs[0].getAccessionId());
- assertEquals(cds2Map.getInverse(), dbrefs[0].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDS, dbrefs[1].getSource());
- assertEquals("CAA30421.1", dbrefs[1].getAccessionId());
- assertEquals(proteinToCdsMap1, dbrefs[1].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDSProduct, dbrefs[2].getSource());
- assertEquals("CAA30421.1", dbrefs[2].getAccessionId());
- assertNull(dbrefs[2].getMap());
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "0", "B0BCM3"),
- dbrefs[3]);
- assertNull(dbrefs[3].getMap());
-
- // dbrefs for second CDS second Uniprot xref
- dbrefs = peptides.get(4).getDBRefs();
- assertEquals(2, dbrefs.length);
- assertEquals(new DBRefEntry(DBRefSource.UNIPROT, "0", "B0BCM3"),
- dbrefs[0]);
- assertNull(dbrefs[0].getMap());
- assertEquals(DBRefSource.EMBL, dbrefs[1].getSource());
- assertEquals("X07547", dbrefs[1].getAccessionId());
- assertEquals(cds2Map.getInverse(), dbrefs[1].getMap().getMap());
-
- // dbrefs for third CDS inferred EMBL product CAA12345.6
- dbrefs = peptides.get(5).getDBRefs();
- assertEquals(3, dbrefs.length);
- assertEquals(DBRefSource.EMBL, dbrefs[0].getSource());
- assertEquals("CAA12345.6", dbrefs[0].getAccessionId());
- assertEquals(cds3Map.getInverse(), dbrefs[0].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDS, dbrefs[1].getSource());
- assertEquals("CAA12345.6", dbrefs[1].getAccessionId());
- assertEquals(proteinToCdsMap2, dbrefs[1].getMap().getMap());
- assertEquals(DBRefSource.EMBLCDSProduct, dbrefs[2].getSource());
- assertEquals("CAA12345.6", dbrefs[2].getAccessionId());
- assertNull(dbrefs[2].getMap());
- }
-
- @Test(groups = "Functional")
- public void testAdjustForProteinLength()
- {
- int[] exons = new int[] { 11, 15, 21, 25, 31, 38 }; // 18 bp
-
- // exact length match:
- assertSame(exons, EmblEntry.adjustForProteinLength(6, exons));
-
- // match if we assume exons include stop codon not in protein:
- assertSame(exons, EmblEntry.adjustForProteinLength(5, exons));
-
- // truncate last exon by 6bp
- int[] truncated = EmblEntry.adjustForProteinLength(4, exons);
- assertEquals("[11, 15, 21, 25, 31, 32]", Arrays.toString(truncated));
-
- // remove last exon and truncate preceding by 1bp
- truncated = EmblEntry.adjustForProteinLength(3, exons);
- assertEquals("[11, 15, 21, 24]", Arrays.toString(truncated));
-
- // exact removal of exon case:
- exons = new int[] { 11, 15, 21, 27, 33, 38 }; // 18 bp
- truncated = EmblEntry.adjustForProteinLength(4, exons);
- assertEquals("[11, 15, 21, 27]", Arrays.toString(truncated));
-
- // what if exons are too short for protein?
- truncated = EmblEntry.adjustForProteinLength(7, exons);
- assertSame(exons, truncated);
- }
-}
git://source.jalview.org / jalview.git / blobdiff