forester/aptx/aptx_example_files/wnt_seed_seqs.xml

   1 <?xml version="1.0" encoding="UTF-8"?>\r
   2 <phyloxml xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.phyloxml.org http://www.phyloxml.org/1.10/phyloxml.xsd" xmlns="http://www.phyloxml.org">\r
   3 <phylogeny rooted="true" rerootable="false">\r
   4   <clade>\r
   5     <taxonomy>\r
   6       <id provider="uniprot">33208</id>\r
   7       <scientific_name>Metazoa</scientific_name>\r
   8       <rank>kingdom</rank>\r
   9     </taxonomy>\r
  10     <clade>\r
  11       <branch_length>0.012195</branch_length>\r
  12       <confidence type="bootstrap">99</confidence>\r
  13       <clade>\r
  14         <branch_length>0.00662</branch_length>\r
  15         <confidence type="bootstrap">28</confidence>\r
  16         <clade>\r
  17           <branch_length>0.00344</branch_length>\r
  18           <confidence type="bootstrap">6</confidence>\r
  19           <clade>\r
  20             <branch_length>0.0022</branch_length>\r
  21             <confidence type="bootstrap">1</confidence>\r
  22             <clade>\r
  23               <branch_length>0.00148</branch_length>\r
  24               <confidence type="bootstrap">0</confidence>\r
  25               <clade>\r
  26                 <branch_length>0.00396</branch_length>\r
  27                 <confidence type="bootstrap">5</confidence>\r
  28                 <clade>\r
  29                   <branch_length>0.00258</branch_length>\r
  30                   <confidence type="bootstrap">15</confidence>\r
  31                   <clade>\r
  32                     <branch_length>0.01323</branch_length>\r
  33                     <confidence type="bootstrap">61</confidence>\r
  34                     <clade>\r
  35                       <branch_length>0.00504</branch_length>\r
  36                       <confidence type="bootstrap">46</confidence>\r
  37                       <clade>\r
  38                         <branch_length>0.01441</branch_length>\r
  39                         <confidence type="bootstrap">65</confidence>\r
  40                         <clade>\r
  41                           <branch_length>0.02347</branch_length>\r
  42                           <confidence type="bootstrap">100</confidence>\r
  43                           <clade>\r
  44                             <branch_length>0.01855</branch_length>\r
  45                             <confidence type="bootstrap">94</confidence>\r
  46                             <color>\r
  47                               <red>20</red>\r
  48                               <green>71</green>\r
  49                               <blue>142</blue>\r
  50                             </color>\r
  51                             <taxonomy>\r
  52                               <id provider="uniprot">117571</id>\r
  53                               <scientific_name>Euteleostomi</scientific_name>\r
  54                             </taxonomy>\r
  55                             <clade>\r
  56                               <branch_length>0.01429</branch_length>\r
  57                               <confidence type="bootstrap">50</confidence>\r
  58                               <color>\r
  59                                 <red>20</red>\r
  60                                 <green>71</green>\r
  61                                 <blue>142</blue>\r
  62                               </color>\r
  63                               <clade>\r
  64                                 <branch_length>0.00777</branch_length>\r
  65                                 <confidence type="bootstrap">57</confidence>\r
  66                                 <color>\r
  67                                   <red>20</red>\r
  68                                   <green>71</green>\r
  69                                   <blue>142</blue>\r
  70                                 </color>\r
  71                                 <clade>\r
  72                                   <name>WNT2_EULMM/40-349</name>\r
  73                                   <branch_length>0.06843</branch_length>\r
  74                                   <color>\r
  75                                     <red>20</red>\r
  76                                     <green>71</green>\r
  77                                     <blue>142</blue>\r
  78                                   </color>\r
  79                                   <taxonomy>\r
  80                                     <id provider="uniprot">30603</id>\r
  81                                     <code>EULMM</code>\r
  82                                     <scientific_name>Eulemur macaco macaco</scientific_name>\r
  83                                     <common_name>Black lemur</common_name>\r
  84                                     <rank>subspecies</rank>\r
  85                                   </taxonomy>\r
  86                                   <sequence type="protein">\r
  87                                     <accession source="uniprot">Q2IBG1</accession>\r
  88                                     <name>Protein Wnt-2</name>\r
  89                                     <gene_name>WNT2</gene_name>\r
  90                                     <mol_seq is_aligned="true">MCDNVPGLV---SRQRQLCHRHPD--------VMRAISLGVSEWTAECQHQFRQHRWNCNTLDRD--------------------------------HSLFGR-VLLRS--SRESAFVYAISSAGVVFAITRACSQGEL-KSCSCDPKK--------------------KGTAKDSKG-------------------------------------------------------------------TFDWGGCSDNI-DYGIKFARAFVDAKE-------RKGKDARAL--MNLHNNRAGRKAVKRFLKQECKCH---GVSGSCTLRT--------------------CWL-AMADFRKTGAYLWRKYNG-AIQVVMNQDGTGFTVA----------------------------------------------------------------------------------------------NKRFK----KP----------TKNDLVYFENSPDYCIRDREA-GSLGTAGRVC-------------NLT-SR---------GMDS-CEVMC--CGRGYDTSRVTRMT-KCECK-FH-----WCCAVRCQDCLEALDVHTCK</mol_seq>\r
  91                                     <annotation ref="GO:0005578">\r
  92                                       <desc>proteinaceous extracellular matrix</desc>\r
  93                                     </annotation>\r
  94                                     <annotation ref="GO:0007275">\r
  95                                       <desc>multicellular organismal development</desc>\r
  96                                     </annotation>\r
  97                                     <annotation ref="GO:0016055">\r
  98                                       <desc>Wnt signaling pathway</desc>\r
  99                                     </annotation>\r
 100                                   </sequence>\r
 101                                 </clade>\r
 102                                 <clade>\r
 103                                   <name>Q4SSA4_TETNG/11-320</name>\r
 104                                   <branch_length>0.06553</branch_length>\r
 105                                   <color>\r
 106                                     <red>20</red>\r
 107                                     <green>71</green>\r
 108                                     <blue>142</blue>\r
 109                                   </color>\r
 110                                   <taxonomy>\r
 111                                     <id provider="uniprot">99883</id>\r
 112                                     <code>TETNG</code>\r
 113                                     <scientific_name>Tetraodon nigroviridis</scientific_name>\r
 114                                     <common_name>Spotted green pufferfish</common_name>\r
 115                                     <synonym>Chelonodon nigroviridis</synonym>\r
 116                                     <rank>species</rank>\r
 117                                   </taxonomy>\r
 118                                   <sequence type="protein">\r
 119                                     <accession source="uniprot">Q4SSA4</accession>\r
 120                                     <name>Protein Wnt</name>\r
 121                                     <mol_seq is_aligned="true">ICDNIPGLV---NKQRQLCQGHPD--------LMRSIGEGAKEWIKECQHQFRHHRWNCSTLDRD--------------------------------HTVFGR-VMLRS--SREAAFVYAISSAGVVYAITRACSQGEL-KSCNCDGQK--------------------RGRSSDATG-------------------------------------------------------------------SFDWGGCSDNI-NYGIKFAKAFVDARE-------KMMKDARAL--MNLHNNRCGRMAVKRFMKLECKCH---GVSGSCSLRT--------------------CWL-AMSDFRRTGDYLRKKYNS-AVEVTMNQDGTGFLVA----------------------------------------------------------------------------------------------DKNFK----GN----------TKNELVYVENSPDYCLMDRSA-GSLGTAGRVC-------------NKS-SR---------GTDG-CEIMC--CGRGYDTMRVKRVT-KCECK-FK-----WCCAVECSDCEDIVDVHTCK</mol_seq>\r
 122                                     <annotation ref="GO:0005578">\r
 123                                       <desc>proteinaceous extracellular matrix</desc>\r
 124                                     </annotation>\r
 125                                     <annotation ref="GO:0007275">\r
 126                                       <desc>multicellular organismal development</desc>\r
 127                                     </annotation>\r
 128                                     <annotation ref="GO:0016055">\r
 129                                       <desc>Wnt signaling pathway</desc>\r
 130                                     </annotation>\r
 131                                   </sequence>\r
 132                                 </clade>\r
 133                               </clade>\r
 134                               <clade>\r
 135                                 <name>Q8UW39_TAKRU/38-347</name>\r
 136                                 <branch_length>0.08277</branch_length>\r
 137                                 <color>\r
 138                                   <red>20</red>\r
 139                                   <green>71</green>\r
 140                                   <blue>142</blue>\r
 141                                 </color>\r
 142                                 <taxonomy>\r
 143                                   <id provider="uniprot">31033</id>\r
 144                                   <code>TAKRU</code>\r
 145                                   <scientific_name>Takifugu rubripes</scientific_name>\r
 146                                   <common_name>Japanese pufferfish</common_name>\r
 147                                   <synonym>Fugu rubripes</synonym>\r
 148                                   <rank>species</rank>\r
 149                                 </taxonomy>\r
 150                                 <sequence type="protein">\r
 151                                   <accession source="uniprot">Q8UW39</accession>\r
 152                                   <name>Protein Wnt</name>\r
 153                                   <gene_name>WNT2</gene_name>\r
 154                                   <mol_seq is_aligned="true">MCDNIPGLV---NKQRQLCRQHPK--------VMQAIGSGIKDWISECQHQFRNHRWNCNTTARD--------------------------------HNLFGR-LLLRS--SREVAFIYALSSAGVVYALARACSQGDL-DSCSCDPAK--------------------KGSSRDAKG-------------------------------------------------------------------SFSWGGCSDHV-DHAMRFSQAFVDAKE-------RKERDARAL--MNLHNNRAGRKAVKRFMTLECKCH---GVSGSCSVRT--------------------CWS-AMADFRRTGDHLRKKYNG-AVQVAVNQYGTGFTTA----------------------------------------------------------------------------------------------HAHFK----QP----------GKNDLVYLEDSPDYCVRDQDS-GSLGTGGRLC-------------NRT-SP---------GTDG-CEVMC--CGRGYDTSRVGRTT-KCECK-FH-----WCCAVLCRDCHQQVDVHTCK</mol_seq>\r
 155                                   <annotation ref="GO:0005578">\r
 156                                     <desc>proteinaceous extracellular matrix</desc>\r
 157                                   </annotation>\r
 158                                   <annotation ref="GO:0007275">\r
 159                                     <desc>multicellular organismal development</desc>\r
 160                                   </annotation>\r
 161                                   <annotation ref="GO:0016055">\r
 162                                     <desc>Wnt signaling pathway</desc>\r
 163                                   </annotation>\r
 164                                   <cross_references>\r
 165                                     <accession source="CTD">7472</accession>\r
 166                                     <accession source="KEGG">tru:100137508</accession>\r
 167                                   </cross_references>\r
 168                                 </sequence>\r
 169                               </clade>\r
 170                             </clade>\r
 171                             <clade>\r
 172                               <name>WNT2B_MOUSE/69-378</name>\r
 173                               <branch_length>0.0898</branch_length>\r
 174                               <color>\r
 175                                 <red>20</red>\r
 176                                 <green>71</green>\r
 177                                 <blue>142</blue>\r
 178                               </color>\r
 179                               <taxonomy>\r
 180                                 <id provider="uniprot">10090</id>\r
 181                                 <code>MOUSE</code>\r
 182                                 <scientific_name>Mus musculus</scientific_name>\r
 183                                 <common_name>Mouse</common_name>\r
 184                                 <rank>species</rank>\r
 185                               </taxonomy>\r
 186                               <sequence type="protein">\r
 187                                 <accession source="uniprot">O70283</accession>\r
 188                                 <name>Protein Wnt-2b</name>\r
 189                                 <gene_name>Wnt2b</gene_name>\r
 190                                 <mol_seq is_aligned="true">ICDNIPGLV---SRQRQLCQRYPD--------IMRSVGEGAREWIRECQHQFRHHRWNCTTLDRD---------------------------------HTVFGRAMLRS--SREAAFVYAISSAGVVHAITRACSQGEL-SVCSCDPYT--------------------RGRHHDQRG-------------------------------------------------------------------DFDWGGCSDNI-HYGVRFAKAFVDAKE-------KRLKDARAL--MNLHNNRCGRTAVRRFLKLECKCH---GVSGSCTLRT--------------------CWR-ALSDFRRTGDYLRRRYDG-AVQVTATQDGANFTAA----------------------------------------------------------------------------------------------RQGYR----HA----------TRTDLVYFDNSPDYCVLDKAA-GSLGTAGRVC-------------SKT-SK---------GTDG-CEIMC--CGRGYDTTRVTRVT-QCECK-FH-----WCCAVRCKECRNTVDVHTCK</mol_seq>\r
 191                                 <annotation ref="GO:0002062">\r
 192                                   <desc>chondrocyte differentiation</desc>\r
 193                                 </annotation>\r
 194                                 <annotation ref="GO:0005102">\r
 195                                   <desc>receptor binding</desc>\r
 196                                 </annotation>\r
 197                                 <annotation ref="GO:0005109">\r
 198                                   <desc>frizzled binding</desc>\r
 199                                 </annotation>\r
 200                                 <annotation ref="GO:0005515">\r
 201                                   <desc>protein binding</desc>\r
 202                                 </annotation>\r
 203                                 <annotation ref="GO:0005578">\r
 204                                   <desc>proteinaceous extracellular matrix</desc>\r
 205                                 </annotation>\r
 206                                 <annotation ref="GO:0005615">\r
 207                                   <desc>extracellular space</desc>\r
 208                                 </annotation>\r
 209                                 <annotation ref="GO:0007165">\r
 210                                   <desc>signal transduction</desc>\r
 211                                 </annotation>\r
 212                                 <annotation ref="GO:0007267">\r
 213                                   <desc>cell-cell signaling</desc>\r
 214                                 </annotation>\r
 215                                 <annotation ref="GO:0008584">\r
 216                                   <desc>male gonad development</desc>\r
 217                                 </annotation>\r
 218                                 <annotation ref="GO:0009267">\r
 219                                   <desc>cellular response to starvation</desc>\r
 220                                 </annotation>\r
 221                                 <annotation ref="GO:0009887">\r
 222                                   <desc>organ morphogenesis</desc>\r
 223                                 </annotation>\r
 224                                 <annotation ref="GO:0021871">\r
 225                                   <desc>forebrain regionalization</desc>\r
 226                                 </annotation>\r
 227                                 <annotation ref="GO:0030182">\r
 228                                   <desc>neuron differentiation</desc>\r
 229                                 </annotation>\r
 230                                 <annotation ref="GO:0060070">\r
 231                                   <desc>canonical Wnt signaling pathway</desc>\r
 232                                 </annotation>\r
 233                                 <annotation ref="GO:0060492">\r
 234                                   <desc>lung induction</desc>\r
 235                                 </annotation>\r
 236                                 <annotation ref="GO:0060638">\r
 237                                   <desc>mesenchymal-epithelial cell signaling</desc>\r
 238                                 </annotation>\r
 239                                 <annotation ref="GO:0071425">\r
 240                                   <desc>hematopoietic stem cell proliferation</desc>\r
 241                                 </annotation>\r
 242                                 <annotation ref="GO:0090190">\r
 243                                   <desc>positive regulation of branching involved in ureteric bud morphogenesis</desc>\r
 244                                 </annotation>\r
 245                                 <annotation ref="GO:0090263">\r
 246                                   <desc>positive regulation of canonical Wnt signaling pathway</desc>\r
 247                                 </annotation>\r
 248                                 <cross_references>\r
 249                                   <accession source="CTD">7482</accession>\r
 250                                   <accession source="KEGG">mmu:22414</accession>\r
 251                                   <accession source="NextBio">302825</accession>\r
 252                                 </cross_references>\r
 253                               </sequence>\r
 254                             </clade>\r
 255                           </clade>\r
 256                           <clade>\r
 257                             <name>A2SVS5_9MOLL/42-350</name>\r
 258                             <branch_length>0.10471</branch_length>\r
 259                             <color>\r
 260                               <red>255</red>\r
 261                               <green>122</green>\r
 262                               <blue>142</blue>\r
 263                             </color>\r
 264                             <taxonomy>\r
 265                               <id provider="uniprot">6613</id>\r
 266                               <code>9MOLL</code>\r
 267                               <scientific_name>Euprymna scolopes</scientific_name>\r
 268                               <rank>phylum</rank>\r
 269                             </taxonomy>\r
 270                             <sequence type="protein">\r
 271                               <accession source="uniprot">A2SVS5</accession>\r
 272                               <name>Protein Wnt</name>\r
 273                               <mol_seq is_aligned="true">MCSNIPGLV---GKQKRLCRVHQD--------VMISLRDGVQLGVKECQFQLRSQRWNCSTLDRD--------------------------------ASVFGK-VMLRG--SREAAFVYAISSAAVVHAITRACSKGIL-RNCSCDPSK--------------------IGKGRDKKG-------------------------------------------------------------------HFEWGGCSDNV-QYGSDFSRTFIDARE-------KKVRDARAL--MNLHNNRAGRRAVKRFLKLECRCH---GVSGSCSIRT--------------------CWS-AMMEFRRVGDYLKNKYNG-AVQVMMNQEGTGLIVA----------------------------------------------------------------------------------------------NKDHK----RP----------TRSDL-YFEASPDYCMRNLEI-GSLGTSGRQC-------------NKT-SL---------GTDG-CDIMC--CGRGYDTETVKQTR-KCQCK-FH-----WCCQVKCKECVEYVDVHTCK</mol_seq>\r
 274                               <annotation ref="GO:0005578">\r
 275                                 <desc>proteinaceous extracellular matrix</desc>\r
 276                               </annotation>\r
 277                               <annotation ref="GO:0007275">\r
 278                                 <desc>multicellular organismal development</desc>\r
 279                               </annotation>\r
 280                               <annotation ref="GO:0016055">\r
 281                                 <desc>Wnt signaling pathway</desc>\r
 282                               </annotation>\r
 283                             </sequence>\r
 284                           </clade>\r
 285                         </clade>\r
 286                         <clade>\r
 287                           <name>Q75PH4_PARTP/59-367</name>\r
 288                           <branch_length>0.15068</branch_length>\r
 289                           <color>\r
 290                             <red>0</red>\r
 291                             <green>173</green>\r
 292                             <blue>193</blue>\r
 293                           </color>\r
 294                           <taxonomy>\r
 295                             <id provider="uniprot">114398</id>\r
 296                             <code>PARTP</code>\r
 297                             <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
 298                             <common_name>House spider</common_name>\r
 299                             <synonym>Achaearanea tepidariorum</synonym>\r
 300                             <rank>species</rank>\r
 301                           </taxonomy>\r
 302                           <sequence type="protein">\r
 303                             <accession source="uniprot">Q75PH4</accession>\r
 304                             <name>Protein Wnt</name>\r
 305                             <gene_name>wnt2</gene_name>\r
 306                             <mol_seq is_aligned="true">LCGGIPGLA---RKQREICEQHPD--------ILLSVTKGARIGVSECQAQFRNQRWNCSTLGSG--------------------------------ASVFGSHMLKVD--SRESAFLYAISSAGVTHAIIRSCSRGEI-PNCPCDPLR--------------------RGFGFDPTV------------------------------------------------------------------GGYSWGGCS-HI-SAGVKFARQFIDARE-------DRRKDARAL--MNFHNNRAGRKAVQKKTRLQCKCH---GVSGSCASRT--------------------CWS-AQMEFREVGRLLKRKYEG-AVQVTMSNQMALVS------------------------------------------------------------------------------------------------VDGTK----PY----------TKLDLIYFESSPDFCAINKSL-GTLGTGGRRC-------------DRD-SK---------GVEG-CAILC--CGKGYDTRRELFAE-KCSCK-FN-----WCCKVKCKVCREWKDVYTCK</mol_seq>\r
 307                             <annotation ref="GO:0005578">\r
 308                               <desc>proteinaceous extracellular matrix</desc>\r
 309                             </annotation>\r
 310                             <annotation ref="GO:0007275">\r
 311                               <desc>multicellular organismal development</desc>\r
 312                             </annotation>\r
 313                             <annotation ref="GO:0016055">\r
 314                               <desc>Wnt signaling pathway</desc>\r
 315                             </annotation>\r
 316                           </sequence>\r
 317                         </clade>\r
 318                       </clade>\r
 319                       <clade>\r
 320                         <name>Q5IHW2_NEMVE/41-346</name>\r
 321                         <branch_length>0.14196</branch_length>\r
 322                         <color>\r
 323                           <red>20</red>\r
 324                           <green>132</green>\r
 325                           <blue>81</blue>\r
 326                         </color>\r
 327                         <taxonomy>\r
 328                           <id provider="uniprot">45351</id>\r
 329                           <code>NEMVE</code>\r
 330                           <scientific_name>Nematostella vectensis</scientific_name>\r
 331                           <common_name>Starlet sea anemone</common_name>\r
 332                           <rank>species</rank>\r
 333                         </taxonomy>\r
 334                         <sequence type="protein">\r
 335                           <accession source="uniprot">Q5IHW2</accession>\r
 336                           <name>Protein Wnt</name>\r
 337                           <gene_name>Wnt2</gene_name>\r
 338                           <mol_seq is_aligned="true">MCNSITGLI---SIQRQMCLDNPD--------VMVSIGKGAKLGVEECQHQFRDQRWNCSTVNGD--------------------------------ATVFGK-VMRRA--SRETAFVYAISSAGVVHEVTRSCSLGEL-KDCSCRNK---------------------KGRSRKG----------------------------------------------------------------------FEWGGCSDNI-QYGLNFAKAFVDSRE--------VEKDARAL--MNLHNNHVGRRVVKTNMSLDCKCH---GVSGSCSVRT--------------------CWK-SISSFRIVGQHLREKYTT-AVQVTVGQSGGELTNA----------------------------------------------------------------------------------------------EVSYK----KP----------SRDDLVYLEDSPNYCMVDSNT-GSLGTSGREC-------------NGS-AS---------DTTGACSLLC--CGRGFNTIQIEEEY-KCHCK-FH-----WCCYVKCQTCRRTVDKHICK</mol_seq>\r
 339                           <annotation ref="GO:0005578">\r
 340                             <desc>proteinaceous extracellular matrix</desc>\r
 341                           </annotation>\r
 342                           <annotation ref="GO:0007275">\r
 343                             <desc>multicellular organismal development</desc>\r
 344                           </annotation>\r
 345                           <annotation ref="GO:0016055">\r
 346                             <desc>Wnt signaling pathway</desc>\r
 347                           </annotation>\r
 348                         </sequence>\r
 349                       </clade>\r
 350                     </clade>\r
 351                     <clade>\r
 352                       <name>Q4H308_CIOIN/51-362</name>\r
 353                       <branch_length>0.18192</branch_length>\r
 354                       <color>\r
 355                         <red>20</red>\r
 356                         <green>71</green>\r
 357                         <blue>142</blue>\r
 358                       </color>\r
 359                       <taxonomy>\r
 360                         <id provider="uniprot">7719</id>\r
 361                         <code>CIOIN</code>\r
 362                         <scientific_name>Ciona intestinalis</scientific_name>\r
 363                         <common_name>Transparent sea squirt</common_name>\r
 364                         <synonym>Ascidia intestinalis</synonym>\r
 365                         <rank>species</rank>\r
 366                       </taxonomy>\r
 367                       <sequence type="protein">\r
 368                         <accession source="uniprot">Q4H308</accession>\r
 369                         <name>Protein Wnt</name>\r
 370                         <gene_name>Ci-Orphan Wnt b</gene_name>\r
 371                         <mol_seq is_aligned="true">ICLQMPLEP----EQKQYCKNHTK--------IMERIRDGTEMAMKECQYQFRNERWNCSSADES---------------------------------QGFGK-VLKRG--TREAAFVGAITSAAVAHEVTRACSRGEL-TECSCDGQK--------------------RMGSYRDHR------------------------------------------------------------------GRFEWAGCSDDV-QFGMSVAKIFVNTKD-------NALHDARAI--MNVHNNRAGRKTVKSFMKRFCKCH---GATDTCPLRT--------------------CWD-ALDSFRLSGNQLKRKYDG-ASRVTVKQGSRKMTLHTT--------------------------------------------------------------------------------------------VSSHK----SP----------TKRDLVYLEDSPNYCVRNEAT-GSLGTSGREC-------------NLS-SK---------GIDG-CSLLC--CGRGHDTSSVTRTRINCACV-FH-----WCCEVRCTNCTNTYDIYTCK</mol_seq>\r
 372                         <annotation ref="GO:0005109">\r
 373                           <desc>frizzled binding</desc>\r
 374                         </annotation>\r
 375                         <annotation ref="GO:0005578">\r
 376                           <desc>proteinaceous extracellular matrix</desc>\r
 377                         </annotation>\r
 378                         <annotation ref="GO:0005615">\r
 379                           <desc>extracellular space</desc>\r
 380                         </annotation>\r
 381                         <annotation ref="GO:0016055">\r
 382                           <desc>Wnt signaling pathway</desc>\r
 383                         </annotation>\r
 384                         <annotation ref="GO:0030182">\r
 385                           <desc>neuron differentiation</desc>\r
 386                         </annotation>\r
 387                         <annotation ref="GO:0045165">\r
 388                           <desc>cell fate commitment</desc>\r
 389                         </annotation>\r
 390                         <cross_references>\r
 391                           <accession source="KEGG">cin:778720</accession>\r
 392                         </cross_references>\r
 393                       </sequence>\r
 394                     </clade>\r
 395                   </clade>\r
 396                   <clade>\r
 397                     <branch_length>0.03087</branch_length>\r
 398                     <confidence type="bootstrap">95</confidence>\r
 399                     <clade>\r
 400                       <branch_length>0.00931</branch_length>\r
 401                       <confidence type="bootstrap">76</confidence>\r
 402                       <clade>\r
 403                         <branch_length>0.05457</branch_length>\r
 404                         <confidence type="bootstrap">100</confidence>\r
 405                         <color>\r
 406                           <red>20</red>\r
 407                           <green>71</green>\r
 408                           <blue>142</blue>\r
 409                         </color>\r
 410                         <taxonomy>\r
 411                           <id provider="uniprot">117571</id>\r
 412                           <scientific_name>Euteleostomi</scientific_name>\r
 413                         </taxonomy>\r
 414                         <clade>\r
 415                           <branch_length>0.02373</branch_length>\r
 416                           <confidence type="bootstrap">90</confidence>\r
 417                           <color>\r
 418                             <red>20</red>\r
 419                             <green>71</green>\r
 420                             <blue>142</blue>\r
 421                           </color>\r
 422                           <clade>\r
 423                             <name>A5WVL3_DANRE/45-356</name>\r
 424                             <branch_length>0.085</branch_length>\r
 425                             <color>\r
 426                               <red>20</red>\r
 427                               <green>71</green>\r
 428                               <blue>142</blue>\r
 429                             </color>\r
 430                             <taxonomy>\r
 431                               <id provider="uniprot">7955</id>\r
 432                               <code>DANRE</code>\r
 433                               <scientific_name>Danio rerio</scientific_name>\r
 434                               <common_name>Zebrafish</common_name>\r
 435                               <synonym>Brachydanio rerio</synonym>\r
 436                               <rank>species</rank>\r
 437                             </taxonomy>\r
 438                             <sequence type="protein">\r
 439                               <accession source="uniprot">A5WVL3</accession>\r
 440                               <name>Protein Wnt</name>\r
 441                               <gene_name>wnt16</gene_name>\r
 442                               <mol_seq is_aligned="true">GCAHLPLSH----KQKELCARKPH--------LLPSVKEGARLGITECQTQFRHERWNCSTRRDP---------------------------------NVFGY-ELTSG--TKETAFIHAVMAAGLVHAVTRSCSAGNM-TECSCDTSL--------------------LGSGSPTE--------------------------------------------------------------------GWHWGGCSDDI-AFGTSFSRRFIDSAAK-----NTSTRGEEALLIMKQHNSEAGRQAVAKTMLTDCRCH---GVSGSCAVKT--------------------CWR-TMAAFERVGAYLKDRYET-SVHVVDRSKRKVRRKD----------------------------------------------------------------------------------------------KEQRH----VP---------ITKDELIFFNKSPNYCLEDRRL-GVTGTRGRKC-------------NRT-SA---------GPDG-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCETMNDMHTCK</mol_seq>\r
 443                               <annotation ref="GO:0005109">\r
 444                                 <desc>frizzled binding</desc>\r
 445                               </annotation>\r
 446                               <annotation ref="GO:0005578">\r
 447                                 <desc>proteinaceous extracellular matrix</desc>\r
 448                               </annotation>\r
 449                               <annotation ref="GO:0005615">\r
 450                                 <desc>extracellular space</desc>\r
 451                               </annotation>\r
 452                               <annotation ref="GO:0007219">\r
 453                                 <desc>Notch signaling pathway</desc>\r
 454                               </annotation>\r
 455                               <annotation ref="GO:0016055">\r
 456                                 <desc>Wnt signaling pathway</desc>\r
 457                               </annotation>\r
 458                               <annotation ref="GO:0030182">\r
 459                                 <desc>neuron differentiation</desc>\r
 460                               </annotation>\r
 461                               <annotation ref="GO:0045165">\r
 462                                 <desc>cell fate commitment</desc>\r
 463                               </annotation>\r
 464                               <annotation ref="GO:0060070">\r
 465                                 <desc>canonical Wnt signaling pathway</desc>\r
 466                               </annotation>\r
 467                               <annotation ref="GO:0060218">\r
 468                                 <desc>hematopoietic stem cell differentiation</desc>\r
 469                               </annotation>\r
 470                               <cross_references>\r
 471                                 <accession source="CTD">51384</accession>\r
 472                                 <accession source="KEGG">dre:791563</accession>\r
 473                                 <accession source="NextBio">20930679</accession>\r
 474                               </cross_references>\r
 475                             </sequence>\r
 476                           </clade>\r
 477                           <clade>\r
 478                             <name>A4ZGN9_XENTR/45-376</name>\r
 479                             <branch_length>0.13469</branch_length>\r
 480                             <color>\r
 481                               <red>20</red>\r
 482                               <green>71</green>\r
 483                               <blue>142</blue>\r
 484                             </color>\r
 485                             <taxonomy>\r
 486                               <id provider="uniprot">8364</id>\r
 487                               <code>XENTR</code>\r
 488                               <scientific_name>Xenopus tropicalis</scientific_name>\r
 489                               <common_name>Western clawed frog</common_name>\r
 490                               <synonym>Silurana tropicalis</synonym>\r
 491                               <rank>species</rank>\r
 492                             </taxonomy>\r
 493                             <sequence type="protein">\r
 494                               <accession source="uniprot">A4ZGN9</accession>\r
 495                               <name>Protein Wnt</name>\r
 496                               <gene_name>wnt16</gene_name>\r
 497                               <mol_seq is_aligned="true">GCTNLPLSF----HQKEMCRKKPY--------LLSSIREGARLGIHECRNQFKHERWNCSVSPTISSASSSFSLS-------------FITSSLASAHTIFGY-ELSSG--TKETAFISAVTAAGLVHSVTRACSAGNM-TECSCDTSL--------------------QNGGSASE--------------------------------------------------------------------GWHWGGCSDDL-QYGMWFSRKFLDAPYK-----NSSGRDSDVLNAMHLHNNEAGRQAVTKLMTVDCRCH---GVSGSCAVKT--------------------CWK-SMSSFEKIGNFLKNKYEN-SIQIADRLKRKVRRRE----------------------------------------------------------------------------------------------KNDRK----IP---------IYKGDLVYTNKSPNYCVEDPKL-GISGTHGREC-------------NRT-SE---------GSDS-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCESMTDVHTCK</mol_seq>\r
 498                               <annotation ref="GO:0005578">\r
 499                                 <desc>proteinaceous extracellular matrix</desc>\r
 500                               </annotation>\r
 501                               <annotation ref="GO:0007219">\r
 502                                 <desc>Notch signaling pathway</desc>\r
 503                               </annotation>\r
 504                               <annotation ref="GO:0016055">\r
 505                                 <desc>Wnt signaling pathway</desc>\r
 506                               </annotation>\r
 507                               <annotation ref="GO:0060218">\r
 508                                 <desc>hematopoietic stem cell differentiation</desc>\r
 509                               </annotation>\r
 510                               <cross_references>\r
 511                                 <accession source="CTD">51384</accession>\r
 512                                 <accession source="KEGG">xtr:100125197</accession>\r
 513                               </cross_references>\r
 514                             </sequence>\r
 515                           </clade>\r
 516                         </clade>\r
 517                         <clade>\r
 518                           <name>Q4T8H0_TETNG/14-319</name>\r
 519                           <branch_length>0.11715</branch_length>\r
 520                           <color>\r
 521                             <red>20</red>\r
 522                             <green>71</green>\r
 523                             <blue>142</blue>\r
 524                           </color>\r
 525                           <taxonomy>\r
 526                             <id provider="uniprot">99883</id>\r
 527                             <code>TETNG</code>\r
 528                             <scientific_name>Tetraodon nigroviridis</scientific_name>\r
 529                             <common_name>Spotted green pufferfish</common_name>\r
 530                             <synonym>Chelonodon nigroviridis</synonym>\r
 531                             <rank>species</rank>\r
 532                           </taxonomy>\r
 533                           <sequence type="protein">\r
 534                             <accession source="uniprot">Q4T8H0</accession>\r
 535                             <name>Protein Wnt</name>\r
 536                             <mol_seq is_aligned="true">NCSHVPLSP----RQRSLCQKKSF--------LLPSIQDGARLAVSECQNQFRHERWNCSTSQTP---------------------------------SVFGQ-ELTSG--TKETAFIYAVMAAGLVHAVTLFCSHGNR-TECACEGRG--------------------RGLAEER----------------------------------------------------------------------WHWGGCSEHV-RYGTWFSRRFMDGGRN------ASSGGGFTLAAMNQHNGEVGRQAVHRLMPTHCRCH---GVSGSCAAKT--------------------CWK-TTAAFERVGVYLKERYER-SVQVTSPSRKRAR-------------------------------------------------------------------------------------------------KAGLR----PP---------VDGQQLVFIHKSPNYCVEDRRR-GVAGTRGRRC-------------SRS-SG---------GADG-CNLLC--CGRGYNTHVVRHVQ-RCDCK-FV-----WCCYVRCRRCERMNDTHTCK</mol_seq>\r
 537                             <annotation ref="GO:0005578">\r
 538                               <desc>proteinaceous extracellular matrix</desc>\r
 539                             </annotation>\r
 540                             <annotation ref="GO:0007219">\r
 541                               <desc>Notch signaling pathway</desc>\r
 542                             </annotation>\r
 543                             <annotation ref="GO:0016055">\r
 544                               <desc>Wnt signaling pathway</desc>\r
 545                             </annotation>\r
 546                             <annotation ref="GO:0060218">\r
 547                               <desc>hematopoietic stem cell differentiation</desc>\r
 548                             </annotation>\r
 549                           </sequence>\r
 550                         </clade>\r
 551                       </clade>\r
 552                       <clade>\r
 553                         <name>Q75PH5_PARTP/46-355</name>\r
 554                         <branch_length>0.13426</branch_length>\r
 555                         <color>\r
 556                           <red>0</red>\r
 557                           <green>173</green>\r
 558                           <blue>193</blue>\r
 559                         </color>\r
 560                         <taxonomy>\r
 561                           <id provider="uniprot">114398</id>\r
 562                           <code>PARTP</code>\r
 563                           <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
 564                           <common_name>House spider</common_name>\r
 565                           <synonym>Achaearanea tepidariorum</synonym>\r
 566                           <rank>species</rank>\r
 567                         </taxonomy>\r
 568                         <sequence type="protein">\r
 569                           <accession source="uniprot">Q75PH5</accession>\r
 570                           <name>Protein Wnt</name>\r
 571                           <gene_name>wnt16-like</gene_name>\r
 572                           <mol_seq is_aligned="true">MCSSVPGLV---MQQQKVCQAHPA--------VIKAVSSGAKRGIHECQNQFRHDRWNCTIEGGE---------------------------------SVFDH-TLQRG--SRETAFIYAITSAGATHAVTQACSAGNL-TDCSCDTSR--------------------QGQSMPEG---------------------------------------------------------------------WKWGGCSDNV-RYGMMFARQFVDAPER-----AERKRDVRAL--MNLHNNNAGRLAIARQMELKCRCH---GVSGSCELKT--------------------CWN-KLPSFEQVGHFLKSKYDN-SIQVSLKAKRRLRRRG----------------------------------------------------------------------------------------------KVKRK----VP---------VQKEDLVHIHRSPNYCIEDFKR-GILGTSGRRC-------------NRT-AK---------GPQS-CNLLC--CGRGYNTQVHRRLE-RCQCK-FH-----WCCYVKCKTCETMEEIYTCK</mol_seq>\r
 573                           <annotation ref="GO:0005578">\r
 574                             <desc>proteinaceous extracellular matrix</desc>\r
 575                           </annotation>\r
 576                           <annotation ref="GO:0007275">\r
 577                             <desc>multicellular organismal development</desc>\r
 578                           </annotation>\r
 579                           <annotation ref="GO:0016055">\r
 580                             <desc>Wnt signaling pathway</desc>\r
 581                           </annotation>\r
 582                         </sequence>\r
 583                       </clade>\r
 584                     </clade>\r
 585                     <clade>\r
 586                       <name>A7S694_NEMVE/17-329</name>\r
 587                       <branch_length>0.16188</branch_length>\r
 588                       <color>\r
 589                         <red>20</red>\r
 590                         <green>132</green>\r
 591                         <blue>81</blue>\r
 592                       </color>\r
 593                       <taxonomy>\r
 594                         <id provider="uniprot">45351</id>\r
 595                         <code>NEMVE</code>\r
 596                         <scientific_name>Nematostella vectensis</scientific_name>\r
 597                         <common_name>Starlet sea anemone</common_name>\r
 598                         <rank>species</rank>\r
 599                       </taxonomy>\r
 600                       <sequence type="protein">\r
 601                         <accession source="uniprot">A7S694</accession>\r
 602                         <name>Protein Wnt</name>\r
 603                         <mol_seq is_aligned="true">SCSRVPGLS---LQQLRMCLQKPD--------VIPSVSQGANIGIHECKKQFKYERWNCSTSNDP---------------------------------TVFGT-LLKIA--HKESAFVYAITSAGVVHAVGKSCSKGNL-TECSCESKR--------------------GARNQPKG---------------------------------------------------------------------WEWGGCSDNV-NYGVWLSKTFVDAPEKAD-RRARSQRKARAM--MNLHNNEAGREAVLALMRVQCRCH---GVSSSCAVKT--------------------CSK-SLPKFEEVGEALKAEYKD-AIRAVYIKRKRKLKRKD---------------------------------------------------------------------------------------------NKKLR----IP-----------SSSLVYLDESPNYCYRDKKL-GIDGTSGREC-------------NKN-SS---------GVDG-CDLLC--CGSGYNTQTVRSVH-SCHCR-FI-----WCCNVVCKKCEKIFDRYTCK</mol_seq>\r
 604                         <annotation ref="GO:0005578">\r
 605                           <desc>proteinaceous extracellular matrix</desc>\r
 606                         </annotation>\r
 607                         <annotation ref="GO:0007275">\r
 608                           <desc>multicellular organismal development</desc>\r
 609                         </annotation>\r
 610                         <annotation ref="GO:0016055">\r
 611                           <desc>Wnt signaling pathway</desc>\r
 612                         </annotation>\r
 613                       </sequence>\r
 614                     </clade>\r
 615                   </clade>\r
 616                 </clade>\r
 617                 <clade>\r
 618                   <branch_length>0.00881</branch_length>\r
 619                   <confidence type="bootstrap">38</confidence>\r
 620                   <clade>\r
 621                     <branch_length>0.02064</branch_length>\r
 622                     <confidence type="bootstrap">70</confidence>\r
 623                     <clade>\r
 624                       <branch_length>0.00813</branch_length>\r
 625                       <confidence type="bootstrap">66</confidence>\r
 626                       <clade>\r
 627                         <branch_length>0.01218</branch_length>\r
 628                         <confidence type="bootstrap">68</confidence>\r
 629                         <clade>\r
 630                           <branch_length>0.02329</branch_length>\r
 631                           <confidence type="bootstrap">96</confidence>\r
 632                           <color>\r
 633                             <red>20</red>\r
 634                             <green>71</green>\r
 635                             <blue>142</blue>\r
 636                           </color>\r
 637                           <taxonomy>\r
 638                             <id provider="uniprot">7711</id>\r
 639                             <scientific_name>Chordata</scientific_name>\r
 640                             <rank>phylum</rank>\r
 641                           </taxonomy>\r
 642                           <clade>\r
 643                             <branch_length>0.02432</branch_length>\r
 644                             <confidence type="bootstrap">99</confidence>\r
 645                             <color>\r
 646                               <red>20</red>\r
 647                               <green>71</green>\r
 648                               <blue>142</blue>\r
 649                             </color>\r
 650                             <taxonomy>\r
 651                               <id provider="uniprot">117571</id>\r
 652                               <scientific_name>Euteleostomi</scientific_name>\r
 653                             </taxonomy>\r
 654                             <clade>\r
 655                               <branch_length>0.01427</branch_length>\r
 656                               <confidence type="bootstrap">72</confidence>\r
 657                               <color>\r
 658                                 <red>20</red>\r
 659                                 <green>71</green>\r
 660                                 <blue>142</blue>\r
 661                               </color>\r
 662                               <clade>\r
 663                                 <name>WNT7B_CHICK/37-349</name>\r
 664                                 <branch_length>0.05239</branch_length>\r
 665                                 <color>\r
 666                                   <red>20</red>\r
 667                                   <green>71</green>\r
 668                                   <blue>142</blue>\r
 669                                 </color>\r
 670                                 <taxonomy>\r
 671                                   <id provider="uniprot">9031</id>\r
 672                                   <code>CHICK</code>\r
 673                                   <scientific_name>Gallus gallus</scientific_name>\r
 674                                   <common_name>Chicken</common_name>\r
 675                                   <rank>species</rank>\r
 676                                 </taxonomy>\r
 677                                 <sequence type="protein">\r
 678                                   <accession source="uniprot">Q3L254</accession>\r
 679                                   <name>Protein Wnt-7b</name>\r
 680                                   <gene_name>WNT7B</gene_name>\r
 681                                   <mol_seq is_aligned="true">ICNKIPGLA---PRQRAICQSRPD--------AIIVIGEGAQMGINECQYQFRYGRWNCSALGEK---------------------------------TVFGQ-ELRVG--SREAAFTYAITAAGVAHAVTAACSQGNL-SNCGCDREK--------------------QGYYNQEE--------------------------------------------------------------------GWKWGGCSADI-RYGIEFSRRFVDARE--------IKKNARRL--MNLHNNEAGRKVLEERMKLECKCH---GVSGSCTTKT--------------------CWT-TLPKFREIGYILKEKYNA-AVQVEVVRASRLRQPTFL-----------------------------------------------------------------------K--------------------IKQIKS-YQKP----------METDLVYIEKSPNYCEEDAST-GSVGTQGRLC-------------NRT-SP---------NADG-CDMMC--CGRGYNTHQYTKVW-QCNCK-FH-----WCCFVKCNTCSERTEVFTCK</mol_seq>\r
 682                                   <annotation ref="GO:0005109">\r
 683                                     <desc>frizzled binding</desc>\r
 684                                   </annotation>\r
 685                                   <annotation ref="GO:0005578">\r
 686                                     <desc>proteinaceous extracellular matrix</desc>\r
 687                                   </annotation>\r
 688                                   <annotation ref="GO:0005615">\r
 689                                     <desc>extracellular space</desc>\r
 690                                   </annotation>\r
 691                                   <annotation ref="GO:0016055">\r
 692                                     <desc>Wnt signaling pathway</desc>\r
 693                                   </annotation>\r
 694                                   <annotation ref="GO:0030182">\r
 695                                     <desc>neuron differentiation</desc>\r
 696                                   </annotation>\r
 697                                   <annotation ref="GO:0045165">\r
 698                                     <desc>cell fate commitment</desc>\r
 699                                   </annotation>\r
 700                                   <annotation ref="GO:0046330">\r
 701                                     <desc>positive regulation of JNK cascade</desc>\r
 702                                   </annotation>\r
 703                                   <annotation ref="GO:0070307">\r
 704                                     <desc>lens fiber cell development</desc>\r
 705                                   </annotation>\r
 706                                   <cross_references>\r
 707                                     <accession source="CTD">7477</accession>\r
 708                                     <accession source="KEGG">gga:427937</accession>\r
 709                                     <accession source="NextBio">20829062</accession>\r
 710                                   </cross_references>\r
 711                                 </sequence>\r
 712                               </clade>\r
 713                               <clade>\r
 714                                 <name>Q4STC2_TETNG/13-326</name>\r
 715                                 <branch_length>0.07007</branch_length>\r
 716                                 <color>\r
 717                                   <red>20</red>\r
 718                                   <green>71</green>\r
 719                                   <blue>142</blue>\r
 720                                 </color>\r
 721                                 <taxonomy>\r
 722                                   <id provider="uniprot">99883</id>\r
 723                                   <code>TETNG</code>\r
 724                                   <scientific_name>Tetraodon nigroviridis</scientific_name>\r
 725                                   <common_name>Spotted green pufferfish</common_name>\r
 726                                   <synonym>Chelonodon nigroviridis</synonym>\r
 727                                   <rank>species</rank>\r
 728                                 </taxonomy>\r
 729                                 <sequence type="protein">\r
 730                                   <accession source="uniprot">Q4STC2</accession>\r
 731                                   <name>Protein Wnt</name>\r
 732                                   <mol_seq is_aligned="true">ICNKIPGLA---PRQRALCQSRPD--------AIIIIGEGAQLGINECQFQFRYSRWNCSTLGER---------------------------------TVFGQ-ELRVG--NREAAFTYAVVAAGVAHAVTKACSQGHL-SQCGCDHEK--------------------QGFHHYHQE-------------------------------------------------------------------GWKWGGCSANV-RYGVEFSRRFVDARE--------IKKNARRL--MNLHNNAAGRKILEERMKLECKCH---GVSGSCTTRT--------------------CWV-TLPKFREIGRLLKERYSA-AVQVEPVRASRLRQPSFL--------------------------------------------------------------------------------------------RLKGARGYQKP----------ADTDLVYLERSPSYCKEDAAT-GSTGTRGRRC-------------DSN-ST---------LTDG-CGAMC--CGRGFDAHRYTRIW-QCNCK-FH-----WCCFVQCSTCSEKSEVFTCK</mol_seq>\r
 733                                   <annotation ref="GO:0005578">\r
 734                                     <desc>proteinaceous extracellular matrix</desc>\r
 735                                   </annotation>\r
 736                                   <annotation ref="GO:0007275">\r
 737                                     <desc>multicellular organismal development</desc>\r
 738                                   </annotation>\r
 739                                   <annotation ref="GO:0016055">\r
 740                                     <desc>Wnt signaling pathway</desc>\r
 741                                   </annotation>\r
 742                                 </sequence>\r
 743                               </clade>\r
 744                             </clade>\r
 745                             <clade>\r
 746                               <name>Q4RJT5_TETNG/37-350</name>\r
 747                               <branch_length>0.07948</branch_length>\r
 748                               <color>\r
 749                                 <red>20</red>\r
 750                                 <green>71</green>\r
 751                                 <blue>142</blue>\r
 752                               </color>\r
 753                               <taxonomy>\r
 754                                 <id provider="uniprot">99883</id>\r
 755                                 <code>TETNG</code>\r
 756                                 <scientific_name>Tetraodon nigroviridis</scientific_name>\r
 757                                 <common_name>Spotted green pufferfish</common_name>\r
 758                                 <synonym>Chelonodon nigroviridis</synonym>\r
 759                                 <rank>species</rank>\r
 760                               </taxonomy>\r
 761                               <sequence type="protein">\r
 762                                 <accession source="uniprot">Q4RJT5</accession>\r
 763                                 <name>Protein Wnt</name>\r
 764                                 <gene_name>WNT7A</gene_name>\r
 765                                 <mol_seq is_aligned="true">ICNKIPGLA---PRQRIICQSRPD--------AIIVIGEGAQMGINECQFQFRNWRWNCSALGER---------------------------------TVFGK-ELKVG--SKEAAFTYAIIAAGVAHAITAACTQGNL-GDCSCDKEK--------------------QGFYSIDQ--------------------------------------------------------------------GWKWGGCSADI-SYGLGFSKVFIDARE--------VKQNARTL--MNLHNNEVGRKVLEKSMQLECKCH---GVSGSCTTKT--------------------CWT-TLPKFRELGYILKEKYVH-AVHVEPVKASRNKRPKFL--------------------------------------------------------------------------------------------KVKKPYSYRKP----------MDTDLVYIDKSPNYCEVDHLT-GSLGTHGRVC-------------NKTMMQ---------HISG-CDLMC--CGRGYNTHQYSRVW-QCNCK-FL-----WCCYVKCNTCSERTEVYTCK</mol_seq>\r
 766                                 <annotation ref="GO:0005578">\r
 767                                   <desc>proteinaceous extracellular matrix</desc>\r
 768                                 </annotation>\r
 769                                 <annotation ref="GO:0007275">\r
 770                                   <desc>multicellular organismal development</desc>\r
 771                                 </annotation>\r
 772                                 <annotation ref="GO:0016055">\r
 773                                   <desc>Wnt signaling pathway</desc>\r
 774                                 </annotation>\r
 775                               </sequence>\r
 776                             </clade>\r
 777                           </clade>\r
 778                           <clade>\r
 779                             <name>O61700_BRAFL/35-347</name>\r
 780                             <branch_length>0.1</branch_length>\r
 781                             <color>\r
 782                               <red>20</red>\r
 783                               <green>71</green>\r
 784                               <blue>142</blue>\r
 785                             </color>\r
 786                             <taxonomy>\r
 787                               <id provider="uniprot">7739</id>\r
 788                               <code>BRAFL</code>\r
 789                               <scientific_name>Branchiostoma floridae</scientific_name>\r
 790                               <common_name>Florida lancelet</common_name>\r
 791                               <synonym>Amphioxus</synonym>\r
 792                               <rank>species</rank>\r
 793                             </taxonomy>\r
 794                             <sequence type="protein">\r
 795                               <accession source="uniprot">O61700</accession>\r
 796                               <name>Protein Wnt</name>\r
 797                               <gene_name>Wnt7b</gene_name>\r
 798                               <mol_seq is_aligned="true">ICNRIPGLV---PRQRAICQTRPD--------LIVAIGEGAQRGIDECRYQFRHSRWNCTGMDND---------------------------------NVFGR-ELRIG--SKEAAFTYAISSAALVHAIVTACSQGNI-SDCGCDRTK--------------------EGDLNDEG---------------------------------------------------------------------WKWGGCSADV-KYGLRFCKKFVDARE--------VEQNARAL--MNLHNNEAGRKVIDQHTRLECKCH---GVSGSCTMKT--------------------CWI-TLPRFREVGNILKEKYHHDAQLVEAVRARRTRRPTFL--------------------------------------------------------------------------------------------KLKNSRTFEKP----------REISLVYLRGSPNYCERDEAT-GSLGTHGRRC-------------NRT-SP---------YQDG-CDLMC--CGRGYNTHQFVKTW-QCNCK-FH-----WCCYVKCNQCSERTEEYTCK</mol_seq>\r
 799                               <annotation ref="GO:0005578">\r
 800                                 <desc>proteinaceous extracellular matrix</desc>\r
 801                               </annotation>\r
 802                               <annotation ref="GO:0007275">\r
 803                                 <desc>multicellular organismal development</desc>\r
 804                               </annotation>\r
 805                               <annotation ref="GO:0016055">\r
 806                                 <desc>Wnt signaling pathway</desc>\r
 807                               </annotation>\r
 808                               <cross_references>\r
 809                                 <accession source="CTD">7215283</accession>\r
 810                               </cross_references>\r
 811                             </sequence>\r
 812                           </clade>\r
 813                         </clade>\r
 814                         <clade>\r
 815                           <branch_length>0.00853</branch_length>\r
 816                           <confidence type="bootstrap">62</confidence>\r
 817                           <clade>\r
 818                             <branch_length>0.02382</branch_length>\r
 819                             <confidence type="bootstrap">100</confidence>\r
 820                             <color>\r
 821                               <red>0</red>\r
 822                               <green>173</green>\r
 823                               <blue>193</blue>\r
 824                             </color>\r
 825                             <taxonomy>\r
 826                               <id provider="uniprot">114398</id>\r
 827                               <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
 828                               <common_name>House spider</common_name>\r
 829                               <synonym>Achaearanea tepidariorum</synonym>\r
 830                               <rank>species</rank>\r
 831                             </taxonomy>\r
 832                             <clade>\r
 833                               <name>Q75PH6_PARTP/41-360</name>\r
 834                               <branch_length>0.10628</branch_length>\r
 835                               <color>\r
 836                                 <red>0</red>\r
 837                                 <green>173</green>\r
 838                                 <blue>193</blue>\r
 839                               </color>\r
 840                               <taxonomy>\r
 841                                 <id provider="uniprot">114398</id>\r
 842                                 <code>PARTP</code>\r
 843                                 <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
 844                                 <common_name>House spider</common_name>\r
 845                                 <synonym>Achaearanea tepidariorum</synonym>\r
 846                                 <rank>species</rank>\r
 847                               </taxonomy>\r
 848                               <sequence type="protein">\r
 849                                 <accession source="uniprot">Q75PH6</accession>\r
 850                                 <name>Protein Wnt</name>\r
 851                                 <gene_name>wnt7-2</gene_name>\r
 852                                 <mol_seq is_aligned="true">ICSKIPGLT---PAQQRLCQERPD--------LIVAVGDGARMGINECQKRFRHRRWNCTAIGSS---------------------------------YVFGH-VVVIG--SREAAYTYAVTSAGVTYAITQACSRGTL-WHCGCDISK--------------------DGMLDPEG--------------------------------------------------------------------GWKWGGCSADV-RHGMKMSRQFMDARE--------IEGDERSL--MNLHNNRAGRKAVLFTVQTECKCH---GVSGSCTMKT--------------------CWL-TLPPFSKTGDYLMRRYQI-AKRVFAHFGGPAKKTTRKTR-------------------------------------------------------------------PLF-L-----------------RTKKSKRPHRKP----------RPRDLVYLEKSPNYCEADPMK-GSTGTSGRLC-------------NRT-SR---------GTDG-CDLLC--CGRGYNTHQFTRTA-QCRCK-FH-----WCCYVDCRVCTERTEVYSCK</mol_seq>\r
 853                                 <annotation ref="GO:0005578">\r
 854                                   <desc>proteinaceous extracellular matrix</desc>\r
 855                                 </annotation>\r
 856                                 <annotation ref="GO:0007275">\r
 857                                   <desc>multicellular organismal development</desc>\r
 858                                 </annotation>\r
 859                                 <annotation ref="GO:0016055">\r
 860                                   <desc>Wnt signaling pathway</desc>\r
 861                                 </annotation>\r
 862                               </sequence>\r
 863                             </clade>\r
 864                             <clade>\r
 865                               <name>Q75PH8_PARTP/42-358</name>\r
 866                               <branch_length>0.10483</branch_length>\r
 867                               <color>\r
 868                                 <red>0</red>\r
 869                                 <green>173</green>\r
 870                                 <blue>193</blue>\r
 871                               </color>\r
 872                               <taxonomy>\r
 873                                 <id provider="uniprot">114398</id>\r
 874                                 <code>PARTP</code>\r
 875                                 <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
 876                                 <common_name>House spider</common_name>\r
 877                                 <synonym>Achaearanea tepidariorum</synonym>\r
 878                                 <rank>species</rank>\r
 879                               </taxonomy>\r
 880                               <sequence type="protein">\r
 881                                 <accession source="uniprot">Q75PH8</accession>\r
 882                                 <name>Protein Wnt</name>\r
 883                                 <gene_name>wnt7-1</gene_name>\r
 884                                 <mol_seq is_aligned="true">ICNKIPGLT---MPQRIFCQTRPD--------IVVAIGEGTRLGVAECQRQFRYHRWNCSTIGSN---------------------------------QVFGH-VIVVG--SREAAYMYSVTSAGVTFVITQSCSRGNV-SDCGCDKSQS-----------------SVKPLNHPTD---------------------------------------------------------------------WKWGGCSVDV-KYGIRLSRKFIDARE--------MEGDARSL--MNLHNNHAGRKAVKHNLKTECKCH---GVSGSCTMKT--------------------CWK-TLPAFAQIGDYLMKAYKQ-SKKVVPHWGPMVTRTPSH-----------------------------------------------------------------------L-------------------KLKKSKRVHRKP----------RPRDLVYLENSPNYCEKDLSR-GSLGTVGREC-------------NRT-SK---------DIDG-CDLLC--CGRGYNTHQYIRTW-QCNCK-FH-----WCCYVNCDVCRERTENYVCK</mol_seq>\r
 885                                 <annotation ref="GO:0005578">\r
 886                                   <desc>proteinaceous extracellular matrix</desc>\r
 887                                 </annotation>\r
 888                                 <annotation ref="GO:0007275">\r
 889                                   <desc>multicellular organismal development</desc>\r
 890                                 </annotation>\r
 891                                 <annotation ref="GO:0016055">\r
 892                                   <desc>Wnt signaling pathway</desc>\r
 893                                 </annotation>\r
 894                               </sequence>\r
 895                             </clade>\r
 896                           </clade>\r
 897                           <clade>\r
 898                             <name>A2SVS9_9MOLL/38-351</name>\r
 899                             <branch_length>0.12678</branch_length>\r
 900                             <color>\r
 901                               <red>255</red>\r
 902                               <green>122</green>\r
 903                               <blue>142</blue>\r
 904                             </color>\r
 905                             <taxonomy>\r
 906                               <id provider="uniprot">6613</id>\r
 907                               <code>9MOLL</code>\r
 908                               <scientific_name>Euprymna scolopes</scientific_name>\r
 909                               <rank>phylum</rank>\r
 910                             </taxonomy>\r
 911                             <sequence type="protein">\r
 912                               <accession source="uniprot">A2SVS9</accession>\r
 913                               <name>Protein Wnt</name>\r
 914                               <mol_seq is_aligned="true">ICNKIPDLV---PKQRSICQRRPD--------AIVVVGEGVKLGIQECRYQFRNMRWNCTHTRSR--------------------------------NSMFAH-VHLVP--NREAAFSFAIVSAGIAYAITQACSRGNL-SRCGCDKSK--------------------LPNYSHNG---------------------------------------------------------------------WKWGGCSADV-KYGLSFARNFVDIRE--------ITKNARAL--MNLHNNRAGRKAVKDNMVTECKCH---GVSGSCTMKT--------------------CWT-TLRPFRMIGNHLMRKYQT-AKITRVIRGSRTLRPIFL-------------------------------------------------------------------------------------------ILKKSKRQNRKP----------RRSDLVCLEKSPNYCDRDERT-GALGTVGRKC-------------LRE-SK---------QTIG-CDLMC--CGRGYNTHQYTVTV-QCACK-FY-----WCCYVRCEKCSNKTEEYTCK</mol_seq>\r
 915                               <annotation ref="GO:0005578">\r
 916                                 <desc>proteinaceous extracellular matrix</desc>\r
 917                               </annotation>\r
 918                               <annotation ref="GO:0007275">\r
 919                                 <desc>multicellular organismal development</desc>\r
 920                               </annotation>\r
 921                               <annotation ref="GO:0016055">\r
 922                                 <desc>Wnt signaling pathway</desc>\r
 923                               </annotation>\r
 924                             </sequence>\r
 925                           </clade>\r
 926                         </clade>\r
 927                       </clade>\r
 928                       <clade>\r
 929                         <branch_length>0.02882</branch_length>\r
 930                         <confidence type="bootstrap">96</confidence>\r
 931                         <color>\r
 932                           <red>0</red>\r
 933                           <green>173</green>\r
 934                           <blue>193</blue>\r
 935                         </color>\r
 936                         <taxonomy>\r
 937                           <id provider="uniprot">7147</id>\r
 938                           <scientific_name>Diptera</scientific_name>\r
 939                           <rank>order</rank>\r
 940                         </taxonomy>\r
 941                         <clade>\r
 942                           <branch_length>0.0487</branch_length>\r
 943                           <confidence type="bootstrap">100</confidence>\r
 944                           <color>\r
 945                             <red>0</red>\r
 946                             <green>173</green>\r
 947                             <blue>193</blue>\r
 948                           </color>\r
 949                           <taxonomy>\r
 950                             <id provider="uniprot">7157</id>\r
 951                             <scientific_name>Culicidae</scientific_name>\r
 952                             <common_name>mosquitos</common_name>\r
 953                             <rank>family</rank>\r
 954                           </taxonomy>\r
 955                           <clade>\r
 956                             <name>Q16Z87_AEDAE/21-350</name>\r
 957                             <branch_length>0.11655</branch_length>\r
 958                             <color>\r
 959                               <red>0</red>\r
 960                               <green>173</green>\r
 961                               <blue>193</blue>\r
 962                             </color>\r
 963                             <taxonomy>\r
 964                               <id provider="uniprot">7159</id>\r
 965                               <code>AEDAE</code>\r
 966                               <scientific_name>Aedes aegypti</scientific_name>\r
 967                               <common_name>Yellowfever mosquito</common_name>\r
 968                               <synonym>Culex aegypti</synonym>\r
 969                               <rank>species</rank>\r
 970                             </taxonomy>\r
 971                             <sequence type="protein">\r
 972                               <accession source="uniprot">Q16Z87</accession>\r
 973                               <name>Protein Wnt</name>\r
 974                               <mol_seq is_aligned="true">LCSRIPGLS---PYQRQLCVEAPD--------AVVSLSTGQKLGAQECQHQFRGHRWNCTQVWKK---------------------------------DMFGH-IVIIG--SREAAFTYGITSAGAVHAITAACAKGNI-TMCGCDSKQ--------------------KMQFSTESD-------------------------------------------------------------------SWKWGGCSADI-GFGMRFTKKFLDARE--------IENDDRSL--MNLHNNRVGRKIVKLLLRTECKCH---GVSGSCAMKT--------------------CWK-SLPPFHAIGDIMMKKYRK-AKMVQATPVVMAMTSTGKINNGQL------------------------------------------------------------QLVLRR-RG---------------KLMQHTSVNSQKP----------KRMELVYLQHSPNYCDRDIAS-GILGTVGRQC-------------NRT-ST---------SMDK-CDLLC--CGRGYNTHQIVKSW-QCNCN-FK-----WCCTVNCDICTERTEEYTCK</mol_seq>\r
 975                               <annotation ref="GO:0005578">\r
 976                                 <desc>proteinaceous extracellular matrix</desc>\r
 977                               </annotation>\r
 978                               <annotation ref="GO:0007275">\r
 979                                 <desc>multicellular organismal development</desc>\r
 980                               </annotation>\r
 981                               <annotation ref="GO:0016055">\r
 982                                 <desc>Wnt signaling pathway</desc>\r
 983                               </annotation>\r
 984                             </sequence>\r
 985                           </clade>\r
 986                           <clade>\r
 987                             <name>A0NG52_ANOGA/28-354</name>\r
 988                             <branch_length>0.19457</branch_length>\r
 989                             <color>\r
 990                               <red>0</red>\r
 991                               <green>173</green>\r
 992                               <blue>193</blue>\r
 993                             </color>\r
 994                             <taxonomy>\r
 995                               <id provider="uniprot">7165</id>\r
 996                               <code>ANOGA</code>\r
 997                               <scientific_name>Anopheles gambiae</scientific_name>\r
 998                               <common_name>African malaria mosquito</common_name>\r
 999                               <rank>species</rank>\r
1000                             </taxonomy>\r
1001                             <sequence type="protein">\r
1002                               <accession source="uniprot">A0NG52</accession>\r
1003                               <name>Protein Wnt</name>\r
1004                               <mol_seq is_aligned="true">LCSRMPGLT---QTQRQICTESSD--------AVVSLASGQWIGASECQKQFHGHRWNCTHVWNT---------------------------------DMFGQ-IVVIG--SREAAYTYAITSAGAVYSITTACAKGNI-TTCGCDMNQ--------------------KIFSSSESE-------------------------------------------------------------------NWKWGGCSVDI-GYGMRFAKKFLDARE--------IENDNRSL--MNMHNNRVGRKPDSILDHTEAG-----NLSWTPHIFTNFSPISLRYPEQFYRPVILNIFA-AFPPYK-----VHVRFHS-PLTISLKGCVKVNNPLLK--------------------------------------------------------------------------------------------NGKTLGDSQIP----------KRTELVYLEPSPNYCERNISI-GVLGTADRNC-------------NRT-SQ---------SIDH-CDLLC--CGRGYNTHQIERTW-QCNCK-FK-----WCCTVTCDVCSERKEAYTCK</mol_seq>\r
1005                               <annotation ref="GO:0005578">\r
1006                                 <desc>proteinaceous extracellular matrix</desc>\r
1007                               </annotation>\r
1008                               <annotation ref="GO:0007275">\r
1009                                 <desc>multicellular organismal development</desc>\r
1010                               </annotation>\r
1011                               <annotation ref="GO:0016055">\r
1012                                 <desc>Wnt signaling pathway</desc>\r
1013                               </annotation>\r
1014                             </sequence>\r
1015                           </clade>\r
1016                         </clade>\r
1017                         <clade>\r
1018                           <name>WNT2_DROME/29-352</name>\r
1019                           <branch_length>0.14749</branch_length>\r
1020                           <color>\r
1021                             <red>0</red>\r
1022                             <green>173</green>\r
1023                             <blue>193</blue>\r
1024                           </color>\r
1025                           <taxonomy>\r
1026                             <id provider="uniprot">7227</id>\r
1027                             <code>DROME</code>\r
1028                             <scientific_name>Drosophila melanogaster</scientific_name>\r
1029                             <common_name>Fruit fly</common_name>\r
1030                             <rank>species</rank>\r
1031                           </taxonomy>\r
1032                           <sequence type="protein">\r
1033                             <accession source="uniprot">P28465</accession>\r
1034                             <name>Protein Wnt-2</name>\r
1035                             <gene_name>Wnt2</gene_name>\r
1036                             <mol_seq is_aligned="true">LCGRIPGLT---PGQRNMCREMPD--------ALIALGEGHQLGAQECQHQFRGHRWNCSEVWQR---------------------------------NVFAH-VIPTA--SREAAYTYAIASAGAAYAVTAACARGNI-STCGCDVRH--------------------KATPTGGGTP----------------------------------------------------------------DEPWKWGGCSADV-DFGMRYARRFMDARE--------LERDSRTL--MNLHNNRAGRTLVKKMLRTDCKCH---GVSGSCVMKT--------------------CWK-SLPPFRLVGDRLMLKYQK-AKTVQAVKGKRGLRLVLSRK-------------------------------------------------------------------KHA-G-----------------TARAQKPVLDWP----------KRMELIYLEASPNYCERSLQT-GSQGTSGRTC-------------QRT-GH---------GPQS-CDLLC--CGRGHNTQHIRRTT-QCRCQ-FR-----WCCEVKCDECDESYEEFTCK</mol_seq>\r
1037                             <annotation ref="GO:0005109">\r
1038                               <desc>frizzled binding</desc>\r
1039                             </annotation>\r
1040                             <annotation ref="GO:0005578">\r
1041                               <desc>proteinaceous extracellular matrix</desc>\r
1042                             </annotation>\r
1043                             <annotation ref="GO:0005615">\r
1044                               <desc>extracellular space</desc>\r
1045                             </annotation>\r
1046                             <annotation ref="GO:0007367">\r
1047                               <desc>segment polarity determination</desc>\r
1048                             </annotation>\r
1049                             <annotation ref="GO:0007424">\r
1050                               <desc>open tracheal system development</desc>\r
1051                             </annotation>\r
1052                             <annotation ref="GO:0007517">\r
1053                               <desc>muscle organ development</desc>\r
1054                             </annotation>\r
1055                             <annotation ref="GO:0016055">\r
1056                               <desc>Wnt signaling pathway</desc>\r
1057                             </annotation>\r
1058                             <annotation ref="GO:0045165">\r
1059                               <desc>cell fate commitment</desc>\r
1060                             </annotation>\r
1061                             <annotation ref="GO:0048675">\r
1062                               <desc>axon extension</desc>\r
1063                             </annotation>\r
1064                             <cross_references>\r
1065                               <accession source="CTD">7472</accession>\r
1066                               <accession source="NextBio">796130</accession>\r
1067                             </cross_references>\r
1068                           </sequence>\r
1069                         </clade>\r
1070                       </clade>\r
1071                     </clade>\r
1072                     <clade>\r
1073                       <name>Q966W2_HALRO/104-436</name>\r
1074                       <branch_length>0.22451</branch_length>\r
1075                       <color>\r
1076                         <red>20</red>\r
1077                         <green>71</green>\r
1078                         <blue>142</blue>\r
1079                       </color>\r
1080                       <taxonomy>\r
1081                         <id provider="uniprot">7729</id>\r
1082                         <code>HALRO</code>\r
1083                         <scientific_name>Halocynthia roretzi</scientific_name>\r
1084                         <common_name>Sea squirt</common_name>\r
1085                         <synonym>Cynthia roretzi</synonym>\r
1086                         <rank>species</rank>\r
1087                       </taxonomy>\r
1088                       <sequence type="protein">\r
1089                         <accession source="uniprot">Q966W2</accession>\r
1090                         <name>Protein Wnt</name>\r
1091                         <gene_name>HrWnt-7</gene_name>\r
1092                         <mol_seq is_aligned="true">ICNKIPGLS---PQQRIRCQSRPD--------AIVAVNEGAHKGLQECQRQFRHHKWNCSTQKER---------------------------------SIFGD-DQKLA--TKEAAIHNAIRAAGVLHAIVTACGEGNL-RDCGCDKSL--------------------RGYFPDESKSKWRRQNIML-----------------------------------------------EMSRRSMSLQTWKWGGCSIDL-KHGIQYSKDFWDSRE--------MRRDARGL--MNLHNYEAGRYAVENNVKLECKCH---GVSASCTTKT--------------------CWL-TLPDFRKVGDTLKKSYER-SRRVTVQTGRIRPMYLI---------------------------------------------------------------------------------------------NLEKRGRSNKP----------RKHDLVYLVPSPEYCENDVIS-ETQGTVGRTC-------------NKT-ST---------GVNS-CDNMC--CGRGYRTHHRVHKW-DCKCK-FF-----WCCHVKCKQCRENVEQYTCL</mol_seq>\r
1093                         <annotation ref="GO:0005578">\r
1094                           <desc>proteinaceous extracellular matrix</desc>\r
1095                         </annotation>\r
1096                         <annotation ref="GO:0007275">\r
1097                           <desc>multicellular organismal development</desc>\r
1098                         </annotation>\r
1099                         <annotation ref="GO:0016055">\r
1100                           <desc>Wnt signaling pathway</desc>\r
1101                         </annotation>\r
1102                       </sequence>\r
1103                     </clade>\r
1104                   </clade>\r
1105                   <clade>\r
1106                     <branch_length>0.13752</branch_length>\r
1107                     <confidence type="bootstrap">100</confidence>\r
1108                     <color>\r
1109                       <red>20</red>\r
1110                       <green>132</green>\r
1111                       <blue>81</blue>\r
1112                     </color>\r
1113                     <taxonomy>\r
1114                       <id provider="uniprot">45351</id>\r
1115                       <scientific_name>Nematostella vectensis</scientific_name>\r
1116                       <common_name>Starlet sea anemone</common_name>\r
1117                       <rank>species</rank>\r
1118                     </taxonomy>\r
1119                     <clade>\r
1120                       <name>Q49N21_NEMVE/28-331</name>\r
1121                       <branch_length>0.0897</branch_length>\r
1122                       <color>\r
1123                         <red>20</red>\r
1124                         <green>132</green>\r
1125                         <blue>81</blue>\r
1126                       </color>\r
1127                       <taxonomy>\r
1128                         <id provider="uniprot">45351</id>\r
1129                         <code>NEMVE</code>\r
1130                         <scientific_name>Nematostella vectensis</scientific_name>\r
1131                         <common_name>Starlet sea anemone</common_name>\r
1132                         <rank>species</rank>\r
1133                       </taxonomy>\r
1134                       <sequence type="protein">\r
1135                         <accession source="uniprot">Q49N21</accession>\r
1136                         <name>Protein Wnt</name>\r
1137                         <mol_seq is_aligned="true">ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVVNRSLLTECTCH---GPSASCVTRT--------------------CSQ-ALPSPRAVSNRLKALYDT-ARRATVYLSSLVRPDDKVE----------------------------------------------------------------------K-------------------V---------------------KPMDLAYLKDSPNYCTKNTLS-KLPGTLGGNC-------------KISDDS---------QEEENCDVMC--CGRGYDTHLITKRW-QCRCK-FV-----WCCNVRCSTCSKRDIVQTCK</mol_seq>\r
1138                         <annotation ref="GO:0005578">\r
1139                           <desc>proteinaceous extracellular matrix</desc>\r
1140                         </annotation>\r
1141                         <annotation ref="GO:0007275">\r
1142                           <desc>multicellular organismal development</desc>\r
1143                         </annotation>\r
1144                         <annotation ref="GO:0016055">\r
1145                           <desc>Wnt signaling pathway</desc>\r
1146                         </annotation>\r
1147                       </sequence>\r
1148                     </clade>\r
1149                     <clade>\r
1150                       <name>Q5IHV9_NEMVE/42-359</name>\r
1151                       <branch_length>0.09414</branch_length>\r
1152                       <color>\r
1153                         <red>20</red>\r
1154                         <green>132</green>\r
1155                         <blue>81</blue>\r
1156                       </color>\r
1157                       <taxonomy>\r
1158                         <id provider="uniprot">45351</id>\r
1159                         <code>NEMVE</code>\r
1160                         <scientific_name>Nematostella vectensis</scientific_name>\r
1161                         <common_name>Starlet sea anemone</common_name>\r
1162                         <rank>species</rank>\r
1163                       </taxonomy>\r
1164                       <sequence type="protein">\r
1165                         <accession source="uniprot">Q5IHV9</accession>\r
1166                         <name>Protein Wnt</name>\r
1167                         <gene_name>Wnt7b</gene_name>\r
1168                         <mol_seq is_aligned="true">ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVIRNNLDLSCKCH---GPSGSCNTKT--------------------CWK-SVPSFRMVGEKLRALYESRQATVKVVAAMKTSKGGQVP---------------------------------------------------------------------AY-I-----------------VVKGTNKVVKPN----------SSANLVYLDNSPSYCNKIKSL-KVPGTVGRVC-------------SRTPES---------AEDVSCEVMC--CGRGYSVREQIKEW-KCHCK-FH-----WCCRVECAKCSKKLMVHTCQ</mol_seq>\r
1169                         <annotation ref="GO:0005578">\r
1170                           <desc>proteinaceous extracellular matrix</desc>\r
1171                         </annotation>\r
1172                         <annotation ref="GO:0007275">\r
1173                           <desc>multicellular organismal development</desc>\r
1174                         </annotation>\r
1175                         <annotation ref="GO:0016055">\r
1176                           <desc>Wnt signaling pathway</desc>\r
1177                         </annotation>\r
1178                       </sequence>\r
1179                     </clade>\r
1180                   </clade>\r
1181                 </clade>\r
1182               </clade>\r
1183               <clade>\r
1184                 <branch_length>0.00446</branch_length>\r
1185                 <confidence type="bootstrap">6</confidence>\r
1186                 <clade>\r
1187                   <branch_length>0.00713</branch_length>\r
1188                   <confidence type="bootstrap">26</confidence>\r
1189                   <clade>\r
1190                     <branch_length>0.01288</branch_length>\r
1191                     <confidence type="bootstrap">37</confidence>\r
1192                     <clade>\r
1193                       <branch_length>0.01922</branch_length>\r
1194                       <confidence type="bootstrap">62</confidence>\r
1195                       <clade>\r
1196                         <branch_length>0.06626</branch_length>\r
1197                         <confidence type="bootstrap">100</confidence>\r
1198                         <clade>\r
1199                           <branch_length>0.04451</branch_length>\r
1200                           <confidence type="bootstrap">100</confidence>\r
1201                           <color>\r
1202                             <red>20</red>\r
1203                             <green>71</green>\r
1204                             <blue>142</blue>\r
1205                           </color>\r
1206                           <taxonomy>\r
1207                             <id provider="uniprot">117571</id>\r
1208                             <scientific_name>Euteleostomi</scientific_name>\r
1209                           </taxonomy>\r
1210                           <clade>\r
1211                             <branch_length>0.01499</branch_length>\r
1212                             <confidence type="bootstrap">67</confidence>\r
1213                             <color>\r
1214                               <red>20</red>\r
1215                               <green>71</green>\r
1216                               <blue>142</blue>\r
1217                             </color>\r
1218                             <clade>\r
1219                               <branch_length>0.0197</branch_length>\r
1220                               <confidence type="bootstrap">85</confidence>\r
1221                               <color>\r
1222                                 <red>20</red>\r
1223                                 <green>71</green>\r
1224                                 <blue>142</blue>\r
1225                               </color>\r
1226                               <clade>\r
1227                                 <name>Q90YJ8_DANRE/18-337</name>\r
1228                                 <branch_length>0.0744</branch_length>\r
1229                                 <color>\r
1230                                   <red>20</red>\r
1231                                   <green>71</green>\r
1232                                   <blue>142</blue>\r
1233                                 </color>\r
1234                                 <taxonomy>\r
1235                                   <id provider="uniprot">7955</id>\r
1236                                   <code>DANRE</code>\r
1237                                   <scientific_name>Danio rerio</scientific_name>\r
1238                                   <common_name>Zebrafish</common_name>\r
1239                                   <synonym>Brachydanio rerio</synonym>\r
1240                                   <rank>species</rank>\r
1241                                 </taxonomy>\r
1242                                 <sequence type="protein">\r
1243                                   <accession source="uniprot">Q90YJ8</accession>\r
1244                                   <name>Protein Wnt</name>\r
1245                                   <gene_name>wnt8a</gene_name>\r
1246                                   <mol_seq is_aligned="true">ILGHTW-------TMNNLLITGPKAY----LTYANSVRVGAQSGIHECKHQFAWDRWNCPDTA-L---------------------------------QLSTHKGLRSA--TRESSFVHAISAAGVMYTLTRNCSLGDL-NECGCDSSR--------------------NGRLGGRG---------------------------------------------------------------------WLWGGCSDNV-DFGERISKQFVDALE--------TGQDARAA--VNLHNNEAGRLAVKATMKRICRCH---GMSESCTMQT--------------------CWM-QLADFREIGNYLKVKHDQ-AQKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------NRVTMTDAFGSI----------ARTELIYLEDSPDYCAKNLSL-GLPGTEGREC-------------VQHGESLS-----QWERRS-CRRLCHECGLRVEERRTEVVS-SCNCK-FH-----WCCTVKCENCSQVTVKHVCT</mol_seq>\r
1247                                   <annotation ref="GO:0005578">\r
1248                                     <desc>proteinaceous extracellular matrix</desc>\r
1249                                   </annotation>\r
1250                                   <annotation ref="GO:0007275">\r
1251                                     <desc>multicellular organismal development</desc>\r
1252                                   </annotation>\r
1253                                   <annotation ref="GO:0016055">\r
1254                                     <desc>Wnt signaling pathway</desc>\r
1255                                   </annotation>\r
1256                                   <cross_references>\r
1257                                     <accession source="NextBio">20880563</accession>\r
1258                                   </cross_references>\r
1259                                 </sequence>\r
1260                               </clade>\r
1261                               <clade>\r
1262                                 <name>Q564K5_CHICK/19-338</name>\r
1263                                 <branch_length>0.06733</branch_length>\r
1264                                 <color>\r
1265                                   <red>20</red>\r
1266                                   <green>71</green>\r
1267                                   <blue>142</blue>\r
1268                                 </color>\r
1269                                 <taxonomy>\r
1270                                   <id provider="uniprot">9031</id>\r
1271                                   <code>CHICK</code>\r
1272                                   <scientific_name>Gallus gallus</scientific_name>\r
1273                                   <common_name>Chicken</common_name>\r
1274                                   <rank>species</rank>\r
1275                                 </taxonomy>\r
1276                                 <sequence type="protein">\r
1277                                   <accession source="uniprot">Q564K5</accession>\r
1278                                   <name>Protein Wnt</name>\r
1279                                   <gene_name>Wnt8c</gene_name>\r
1280                                   <mol_seq is_aligned="true">LNAAAW-------SVNNFLMTGPKAY----LTYSSSVAAGAQSGMEECKFQFGWERWNCPESA-L---------------------------------QLSTHNRLRSA--TRETSFVHAISSAGVMYTLTRNCSLGDF-ESCGCDDSR--------------------NGRVGGRG---------------------------------------------------------------------WVWGGCSDNV-EFGERISKLFVDALE--------TGHDTRAL--INLHNNEVGRLAVKATMKRACKCH---GVSGSCSIQT--------------------CWL-QLADFREIGNYLKMKYDQ-AHKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------SRGATAETFHHV----------HSTELVFLEDSPDYCTRNASL-GHHGTEGREC-------------LQTGKNLS-----QWERRS-CRRLCTECGLKVEERRTEVVS-SCNCK-FH-----WCCTVRCEQCRQLVAKHFCA</mol_seq>\r
1281                                   <annotation ref="GO:0000902">\r
1282                                     <desc>cell morphogenesis</desc>\r
1283                                   </annotation>\r
1284                                   <annotation ref="GO:0005109">\r
1285                                     <desc>frizzled binding</desc>\r
1286                                   </annotation>\r
1287                                   <annotation ref="GO:0005578">\r
1288                                     <desc>proteinaceous extracellular matrix</desc>\r
1289                                   </annotation>\r
1290                                   <annotation ref="GO:0005615">\r
1291                                     <desc>extracellular space</desc>\r
1292                                   </annotation>\r
1293                                   <annotation ref="GO:0007492">\r
1294                                     <desc>endoderm development</desc>\r
1295                                   </annotation>\r
1296                                   <annotation ref="GO:0009949">\r
1297                                     <desc>polarity specification of anterior/posterior axis</desc>\r
1298                                   </annotation>\r
1299                                   <annotation ref="GO:0010085">\r
1300                                     <desc>polarity specification of proximal/distal axis</desc>\r
1301                                   </annotation>\r
1302                                   <annotation ref="GO:0030182">\r
1303                                     <desc>neuron differentiation</desc>\r
1304                                   </annotation>\r
1305                                   <annotation ref="GO:0032880">\r
1306                                     <desc>regulation of protein localization</desc>\r
1307                                   </annotation>\r
1308                                   <annotation ref="GO:0035116">\r
1309                                     <desc>embryonic hindlimb morphogenesis</desc>\r
1310                                   </annotation>\r
1311                                   <annotation ref="GO:0045165">\r
1312                                     <desc>cell fate commitment</desc>\r
1313                                   </annotation>\r
1314                                   <annotation ref="GO:0045743">\r
1315                                     <desc>positive regulation of fibroblast growth factor receptor signaling pathway</desc>\r
1316                                   </annotation>\r
1317                                   <annotation ref="GO:0048561">\r
1318                                     <desc>establishment of organ orientation</desc>\r
1319                                   </annotation>\r
1320                                   <annotation ref="GO:0060021">\r
1321                                     <desc>palate development</desc>\r
1322                                   </annotation>\r
1323                                   <annotation ref="GO:0060828">\r
1324                                     <desc>regulation of canonical Wnt signaling pathway</desc>\r
1325                                   </annotation>\r
1326                                   <annotation ref="GO:0061317">\r
1327                                     <desc>canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment</desc>\r
1328                                   </annotation>\r
1329                                 </sequence>\r
1330                               </clade>\r
1331                             </clade>\r
1332                             <clade>\r
1333                               <name>Q0VBT1_MOUSE/18-337</name>\r
1334                               <branch_length>0.10083</branch_length>\r
1335                               <color>\r
1336                                 <red>20</red>\r
1337                                 <green>71</green>\r
1338                                 <blue>142</blue>\r
1339                               </color>\r
1340                               <taxonomy>\r
1341                                 <id provider="uniprot">10090</id>\r
1342                                 <code>MOUSE</code>\r
1343                                 <scientific_name>Mus musculus</scientific_name>\r
1344                                 <common_name>Mouse</common_name>\r
1345                                 <rank>species</rank>\r
1346                               </taxonomy>\r
1347                               <sequence type="protein">\r
1348                                 <accession source="uniprot">Q0VBT1</accession>\r
1349                                 <name>Protein Wnt</name>\r
1350                                 <gene_name>Wnt8a</gene_name>\r
1351                                 <mol_seq is_aligned="true">LGASAW-------SVNNFLITGPKAY----LTYTASVALGAQIGIEECKFQFAWERWNCPEHA-F---------------------------------QFSTHNRLRAA--TRETSFIHAIRSAAIMYAVTKNCSMGDL-ENCGCDESQ--------------------NGKTGGHG---------------------------------------------------------------------WIWGGCSDNV-EFGEKISRLFVDSLE--------KGKDARAL--VNLHNNRAGRLAVRASTKRTCKCH---GISGSCSIQT--------------------CWL-QLADFRQMGNYLKAKYDR-ALKIEMDKRQLRAGNRAE-------------------------------------------------------------------------------------------GRWALTEAFLPS----------TEAELIFLEGSPDYCNRNASL-SIQGTEGREC-------------LQNARSAS-----RREQRS-CGRLCTECGLQVEERRAEAVS-SCDCN-FQ-----WCCTVKCGQCRRVVSRYYCT</mol_seq>\r
1352                                 <annotation ref="GO:0000902">\r
1353                                   <desc>cell morphogenesis</desc>\r
1354                                 </annotation>\r
1355                                 <annotation ref="GO:0003002">\r
1356                                   <desc>regionalization</desc>\r
1357                                 </annotation>\r
1358                                 <annotation ref="GO:0005109">\r
1359                                   <desc>frizzled binding</desc>\r
1360                                 </annotation>\r
1361                                 <annotation ref="GO:0005515">\r
1362                                   <desc>protein binding</desc>\r
1363                                 </annotation>\r
1364                                 <annotation ref="GO:0005578">\r
1365                                   <desc>proteinaceous extracellular matrix</desc>\r
1366                                 </annotation>\r
1367                                 <annotation ref="GO:0005615">\r
1368                                   <desc>extracellular space</desc>\r
1369                                 </annotation>\r
1370                                 <annotation ref="GO:0007492">\r
1371                                   <desc>endoderm development</desc>\r
1372                                 </annotation>\r
1373                                 <annotation ref="GO:0009949">\r
1374                                   <desc>polarity specification of anterior/posterior axis</desc>\r
1375                                 </annotation>\r
1376                                 <annotation ref="GO:0010085">\r
1377                                   <desc>polarity specification of proximal/distal axis</desc>\r
1378                                 </annotation>\r
1379                                 <annotation ref="GO:0016055">\r
1380                                   <desc>Wnt signaling pathway</desc>\r
1381                                 </annotation>\r
1382                                 <annotation ref="GO:0030182">\r
1383                                   <desc>neuron differentiation</desc>\r
1384                                 </annotation>\r
1385                                 <annotation ref="GO:0032880">\r
1386                                   <desc>regulation of protein localization</desc>\r
1387                                 </annotation>\r
1388                                 <annotation ref="GO:0045165">\r
1389                                   <desc>cell fate commitment</desc>\r
1390                                 </annotation>\r
1391                                 <annotation ref="GO:0048561">\r
1392                                   <desc>establishment of organ orientation</desc>\r
1393                                 </annotation>\r
1394                                 <cross_references>\r
1395                                   <accession source="CTD">7478</accession>\r
1396                                   <accession source="KEGG">mmu:20890</accession>\r
1397                                   <accession source="NextBio">299745</accession>\r
1398                                 </cross_references>\r
1399                               </sequence>\r
1400                             </clade>\r
1401                           </clade>\r
1402                           <clade>\r
1403                             <name>WNT8B_HUMAN/15-334</name>\r
1404                             <branch_length>0.0957</branch_length>\r
1405                             <color>\r
1406                               <red>20</red>\r
1407                               <green>71</green>\r
1408                               <blue>142</blue>\r
1409                             </color>\r
1410                             <taxonomy>\r
1411                               <id provider="uniprot">9606</id>\r
1412                               <code>HUMAN</code>\r
1413                               <scientific_name>Homo sapiens</scientific_name>\r
1414                               <common_name>Human</common_name>\r
1415                               <rank>species</rank>\r
1416                             </taxonomy>\r
1417                             <sequence type="protein">\r
1418                               <accession source="uniprot">Q93098</accession>\r
1419                               <name>Protein Wnt-8b</name>\r
1420                               <gene_name>WNT8B</gene_name>\r
1421                               <mol_seq is_aligned="true">CVLQLSHSW----SVNNFLMTGPKAY----LIYSSSVAAGAQSGIEECKYQFAWDRWNCPERA-L---------------------------------QLSSHGGLRSA--NRETAFVHAISSAGVMYTLTRNCSLGDF-DNCGCDDSR--------------------NGQLGGQG---------------------------------------------------------------------WLWGGCSDNV-GFGEAISKQFVDALE--------TGQDARAA--MNLHNNEAGRKAVKGTMKRTCKCH---GVSGSCTTQT--------------------CWL-QLPEFREVGAHLKEKYHA-ALKVDLLQG---AGNSAA-------------------------------------------------------------------------------------------GRGAIADTFRSI----------STRELVHLEDSPDYCLENKTL-GLLGTEGREC-------------LRRGRALG-----RWERRS-CRRLCGDCGLAVEERRAETVS-SCNCK-FH-----WCCAVRCEQCRRRVTKYFCS</mol_seq>\r
1422                               <annotation ref="GO:0005109">\r
1423                                 <desc>frizzled binding</desc>\r
1424                               </annotation>\r
1425                               <annotation ref="GO:0005576">\r
1426                                 <desc>extracellular region</desc>\r
1427                               </annotation>\r
1428                               <annotation ref="GO:0005578">\r
1429                                 <desc>proteinaceous extracellular matrix</desc>\r
1430                               </annotation>\r
1431                               <annotation ref="GO:0005615">\r
1432                                 <desc>extracellular space</desc>\r
1433                               </annotation>\r
1434                               <annotation ref="GO:0007165">\r
1435                                 <desc>signal transduction</desc>\r
1436                               </annotation>\r
1437                               <annotation ref="GO:0007369">\r
1438                                 <desc>gastrulation</desc>\r
1439                               </annotation>\r
1440                               <annotation ref="GO:0007399">\r
1441                                 <desc>nervous system development</desc>\r
1442                               </annotation>\r
1443                               <annotation ref="GO:0010628">\r
1444                                 <desc>positive regulation of gene expression</desc>\r
1445                               </annotation>\r
1446                               <annotation ref="GO:0010629">\r
1447                                 <desc>negative regulation of gene expression</desc>\r
1448                               </annotation>\r
1449                               <annotation ref="GO:0016055">\r
1450                                 <desc>Wnt signaling pathway</desc>\r
1451                               </annotation>\r
1452                               <annotation ref="GO:0030182">\r
1453                                 <desc>neuron differentiation</desc>\r
1454                               </annotation>\r
1455                               <annotation ref="GO:0032355">\r
1456                                 <desc>response to estradiol</desc>\r
1457                               </annotation>\r
1458                               <annotation ref="GO:0032526">\r
1459                                 <desc>response to retinoic acid</desc>\r
1460                               </annotation>\r
1461                               <annotation ref="GO:0045165">\r
1462                                 <desc>cell fate commitment</desc>\r
1463                               </annotation>\r
1464                               <annotation ref="GO:0048263">\r
1465                                 <desc>determination of dorsal identity</desc>\r
1466                               </annotation>\r
1467                               <annotation ref="GO:0071300">\r
1468                                 <desc>cellular response to retinoic acid</desc>\r
1469                               </annotation>\r
1470                               <cross_references>\r
1471                                 <accession source="CTD">7479</accession>\r
1472                                 <accession source="KEGG">hsa:7479</accession>\r
1473                                 <accession source="MIM">601396</accession>\r
1474                                 <accession source="NextBio">29296</accession>\r
1475                                 <accession source="PharmGKB">PA37390</accession>\r
1476                               </cross_references>\r
1477                             </sequence>\r
1478                           </clade>\r
1479                         </clade>\r
1480                         <clade>\r
1481                           <branch_length>0.00972</branch_length>\r
1482                           <confidence type="bootstrap">62</confidence>\r
1483                           <clade>\r
1484                             <name>Q9U416_BRABE/27-337</name>\r
1485                             <branch_length>0.14387</branch_length>\r
1486                             <color>\r
1487                               <red>20</red>\r
1488                               <green>71</green>\r
1489                               <blue>142</blue>\r
1490                             </color>\r
1491                             <taxonomy>\r
1492                               <id provider="uniprot">7741</id>\r
1493                               <code>BRABE</code>\r
1494                               <scientific_name>Branchiostoma belcheri</scientific_name>\r
1495                               <common_name>Amphioxus</common_name>\r
1496                               <rank>species</rank>\r
1497                             </taxonomy>\r
1498                             <sequence type="protein">\r
1499                               <accession source="uniprot">Q9U416</accession>\r
1500                               <name>Protein Wnt</name>\r
1501                               <gene_name>wnt8</gene_name>\r
1502                               <mol_seq is_aligned="true">L-------------QNNILITGPKSSFQASLTYASSVAAGAQTAMEECKYQFSWDRWNCTDNA-L---------------------------------AMFKPNTLP-A--NRETSFVHAISAAGVMYVLTRNCSKGAF-EQCGCDVTN--------------------NGKKAEGG---------------------------------------------------------------------WTWGGCSDDI-AFGERISKMYSDGVE--------NGQDARAA--MNLHNNDVGRKAVRQTMKRVCKCH---GVSGSCTTKT--------------------CWL-QLADFRAIGVFLKKKYKK-ADKVDYVRGQLTENNSAS-------------------------------------------------------------------------------------------SKRNTG----------------LKKDMVFLEDSPDYCRENLTV-GSRGTLGREC-------------LRGGKNRD-----KYEKKS-CKRLCKDCGYVPKRITTEVTS-SCNCK-FH-----WCCSVKCSQCTKTVTKYICV</mol_seq>\r
1503                               <annotation ref="GO:0005578">\r
1504                                 <desc>proteinaceous extracellular matrix</desc>\r
1505                               </annotation>\r
1506                               <annotation ref="GO:0007275">\r
1507                                 <desc>multicellular organismal development</desc>\r
1508                               </annotation>\r
1509                               <annotation ref="GO:0016055">\r
1510                                 <desc>Wnt signaling pathway</desc>\r
1511                               </annotation>\r
1512                             </sequence>\r
1513                           </clade>\r
1514                           <clade>\r
1515                             <name>Q6QWF4_HELTB/9-337</name>\r
1516                             <branch_length>0.21462</branch_length>\r
1517                             <color>\r
1518                               <red>40</red>\r
1519                               <green>20</green>\r
1520                               <blue>71</blue>\r
1521                             </color>\r
1522                             <taxonomy>\r
1523                               <id provider="uniprot">7635</id>\r
1524                               <code>HELTB</code>\r
1525                               <scientific_name>Heliocidaris tuberculata</scientific_name>\r
1526                               <common_name>Sea urchin</common_name>\r
1527                               <rank>species</rank>\r
1528                             </taxonomy>\r
1529                             <sequence type="protein">\r
1530                               <accession source="uniprot">Q6QWF4</accession>\r
1531                               <name>Protein Wnt</name>\r
1532                               <mol_seq is_aligned="true">S------------PASNVLLAGSKSKS--HVTYIDSVSAGIQNAVQECQYQFKWDKWNCPEA------------------------------------SVFTNT---QA--NREMSFVQAIASAGVMYSLTRNCSQGAF-EDCGCDERR--------------------NGDTGGEG---------------------------------------------------------------------WTWGGCSDNV-RFGERMASDIMDDSE--------KSQGAISV--MNLHNNEAGRKAVKQTLQRTCKCH---GVSGSCSLQT--------------------CWN-HVANFRVVGDEIKRKYFK-AVRVDFVSGKLIDGNRPE-------------------------------------------------------------------------------------------DRFPRAVMTASL----------NRRDLVFLDQSPDYCRANLTI-GITGTAGRECMVRQDVDDSSSSSSLT-KDMTSPSSFRWVKQS-CSRLCRSCGMEIRQTEVVITS-SCNCN-FV-----WCCQVKCDTCRRTVTRRTCQ</mol_seq>\r
1533                               <annotation ref="GO:0005578">\r
1534                                 <desc>proteinaceous extracellular matrix</desc>\r
1535                               </annotation>\r
1536                               <annotation ref="GO:0007275">\r
1537                                 <desc>multicellular organismal development</desc>\r
1538                               </annotation>\r
1539                               <annotation ref="GO:0016055">\r
1540                                 <desc>Wnt signaling pathway</desc>\r
1541                               </annotation>\r
1542                             </sequence>\r
1543                           </clade>\r
1544                         </clade>\r
1545                       </clade>\r
1546                       <clade>\r
1547                         <name>Q5IHV8_NEMVE/13-321</name>\r
1548                         <branch_length>0.23494</branch_length>\r
1549                         <color>\r
1550                           <red>20</red>\r
1551                           <green>132</green>\r
1552                           <blue>81</blue>\r
1553                         </color>\r
1554                         <taxonomy>\r
1555                           <id provider="uniprot">45351</id>\r
1556                           <code>NEMVE</code>\r
1557                           <scientific_name>Nematostella vectensis</scientific_name>\r
1558                           <common_name>Starlet sea anemone</common_name>\r
1559                           <rank>species</rank>\r
1560                         </taxonomy>\r
1561                         <sequence type="protein">\r
1562                           <accession source="uniprot">Q5IHV8</accession>\r
1563                           <name>Protein Wnt</name>\r
1564                           <gene_name>Wnt8b</gene_name>\r
1565                           <mol_seq is_aligned="true">VLKVLRGRE-----------AYDK--------LVSSIQKGAKLGLQECRSQFRNEKWNCTMAVKTKNKS------------------------TSKQNPAYVMSMVPHA--TREMAFAHGISAAGVTFALTMDCRLGAF-EDCSCIHGK--------------------SEGNKGN----------------------------------------------------------------------W-WGGCNENV-KFGEVMARHFLEALQ--------SGKDERSL--LNVHNNEVGRKAVRATLKRECRCH---GISGSCSTRT--------------------CWR-KLSSFAEVGQYLVEKYST-AKRVIFQNGNFYELTMLG-------------------------------------------------------------------------------------------TRPISK----------------KDNNFIYSESSPDYCQRNMTV-GSAGVLGREC-------------EGS-KD---------ELVR-CRQLCDSCRFDTQEFTEIKNT-FCNCK-FH-----WCCKVKCMTCKETTRKTRCV</mol_seq>\r
1566                           <annotation ref="GO:0005578">\r
1567                             <desc>proteinaceous extracellular matrix</desc>\r
1568                           </annotation>\r
1569                           <annotation ref="GO:0007275">\r
1570                             <desc>multicellular organismal development</desc>\r
1571                           </annotation>\r
1572                           <annotation ref="GO:0016055">\r
1573                             <desc>Wnt signaling pathway</desc>\r
1574                           </annotation>\r
1575                         </sequence>\r
1576                       </clade>\r
1577                     </clade>\r
1578                     <clade>\r
1579                       <branch_length>0.00862</branch_length>\r
1580                       <confidence type="bootstrap">33</confidence>\r
1581                       <clade>\r
1582                         <branch_length>0.02008</branch_length>\r
1583                         <confidence type="bootstrap">88</confidence>\r
1584                         <clade>\r
1585                           <branch_length>0.02595</branch_length>\r
1586                           <confidence type="bootstrap">92</confidence>\r
1587                           <clade>\r
1588                             <name>WNT8_DROME/15-309</name>\r
1589                             <branch_length>0.3095</branch_length>\r
1590                             <color>\r
1591                               <red>0</red>\r
1592                               <green>173</green>\r
1593                               <blue>193</blue>\r
1594                             </color>\r
1595                             <taxonomy>\r
1596                               <id provider="uniprot">7227</id>\r
1597                               <code>DROME</code>\r
1598                               <scientific_name>Drosophila melanogaster</scientific_name>\r
1599                               <common_name>Fruit fly</common_name>\r
1600                               <rank>species</rank>\r
1601                             </taxonomy>\r
1602                             <sequence type="protein">\r
1603                               <accession source="uniprot">Q9VFX1</accession>\r
1604                               <name>Wnt inhibitor of Dorsal protein</name>\r
1605                               <gene_name>wntD</gene_name>\r
1606                               <mol_seq is_aligned="true">LAAVLEPMSYYQYTQFQAPLSWED-----------ITGKGLKQALDSCQQSFQWQRWNCPSQD-F--------------------------------VQKNSKPEENSP--NREDVYVAAISMAAIVHTLTKDCANGVI-AGCGCTENA--------------------------------------------------------------------------------------------------LNVPCAHEPTKALEQYEKHFGSGSG------------------AIGHNRRVVGALLQRSLEQECRCKQPGAVQGECQEEE--------------------CVA-VLKPFEAIAQDLLQMYDD-AIQLEGASSNLKIMWQNI-----------------------------------------------------------------------------------------------------------------PLDSLVFMQDSPNYCERDATG-LWKGTRGRQC-------------SKD-GSG------SLEERLSCQQLCRVCGYRVRSQHVRTER-RCNCK-LV-----WGFRLQCDVCVQLERQYSCY</mol_seq>\r
1607                               <annotation ref="GO:0005109">\r
1608                                 <desc>frizzled binding</desc>\r
1609                               </annotation>\r
1610                               <annotation ref="GO:0005576">\r
1611                                 <desc>extracellular region</desc>\r
1612                               </annotation>\r
1613                               <annotation ref="GO:0005578">\r
1614                                 <desc>proteinaceous extracellular matrix</desc>\r
1615                               </annotation>\r
1616                               <annotation ref="GO:0005615">\r
1617                                 <desc>extracellular space</desc>\r
1618                               </annotation>\r
1619                               <annotation ref="GO:0007280">\r
1620                                 <desc>pole cell migration</desc>\r
1621                               </annotation>\r
1622                               <annotation ref="GO:0007370">\r
1623                                 <desc>ventral furrow formation</desc>\r
1624                               </annotation>\r
1625                               <annotation ref="GO:0016055">\r
1626                                 <desc>Wnt signaling pathway</desc>\r
1627                               </annotation>\r
1628                               <annotation ref="GO:0030182">\r
1629                                 <desc>neuron differentiation</desc>\r
1630                               </annotation>\r
1631                               <annotation ref="GO:0045165">\r
1632                                 <desc>cell fate commitment</desc>\r
1633                               </annotation>\r
1634                               <annotation ref="GO:0045995">\r
1635                                 <desc>regulation of embryonic development</desc>\r
1636                               </annotation>\r
1637                               <annotation ref="GO:0050830">\r
1638                                 <desc>defense response to Gram-positive bacterium</desc>\r
1639                               </annotation>\r
1640                               <cross_references>\r
1641                                 <accession source="CTD">41633</accession>\r
1642                                 <accession source="NextBio">824739</accession>\r
1643                                 <accession source="PDB" comment="X-ray">4KRR</accession>\r
1644                               </cross_references>\r
1645                             </sequence>\r
1646                           </clade>\r
1647                           <clade>\r
1648                             <name>Q675W2_OIKDI/28-306</name>\r
1649                             <branch_length>0.27475</branch_length>\r
1650                             <color>\r
1651                               <red>20</red>\r
1652                               <green>71</green>\r
1653                               <blue>142</blue>\r
1654                             </color>\r
1655                             <taxonomy>\r
1656                               <id provider="uniprot">34765</id>\r
1657                               <code>OIKDI</code>\r
1658                               <scientific_name>Oikopleura dioica</scientific_name>\r
1659                               <common_name>Tunicate</common_name>\r
1660                               <rank>species</rank>\r
1661                             </taxonomy>\r
1662                             <sequence type="protein">\r
1663                               <accession source="uniprot">Q675W2</accession>\r
1664                               <name>Protein Wnt</name>\r
1665                               <mol_seq is_aligned="true">ICE-FEGLT---RPQKRLCQKYPK--------FQPALKAASLSTINLCKSSMKGHLWGCKGAD-K---------------------------------LPAIGPELSEA--TSESAFVHALGAGQLLAALKTICRTGAS-GSCDEDELR------------------------------------------------------------------------------------------------------------MFAIQFTDVLAMSRR------------AKGQKTVELHNNDVGRSTADRHSRLVCKCH---GQSGSCTQKT--------------------CWR-GSPDPEKVATELSTKYES-AAKVRAQDELPAIFRQYV-----------------------------------------------------------------------------------------------------------------VRDRLLYIKNSINHCEI---------TKGREC-------------NPY-SS---------EKSS-CERLC--CGRGFITRLHKEPRRECKMQTIEVDGSLWPAGITCKTVYDSSISHSCR</mol_seq>\r
1666                               <annotation ref="GO:0005578">\r
1667                                 <desc>proteinaceous extracellular matrix</desc>\r
1668                               </annotation>\r
1669                               <annotation ref="GO:0007275">\r
1670                                 <desc>multicellular organismal development</desc>\r
1671                               </annotation>\r
1672                               <annotation ref="GO:0016055">\r
1673                                 <desc>Wnt signaling pathway</desc>\r
1674                               </annotation>\r
1675                               <cross_references>\r
1676                                 <accession source="CTD">6166716</accession>\r
1677                               </cross_references>\r
1678                             </sequence>\r
1679                           </clade>\r
1680                         </clade>\r
1681                         <clade>\r
1682                           <branch_length>0.12867</branch_length>\r
1683                           <confidence type="bootstrap">100</confidence>\r
1684                           <color>\r
1685                             <red>132</red>\r
1686                             <green>40</green>\r
1687                             <blue>122</blue>\r
1688                           </color>\r
1689                           <taxonomy>\r
1690                             <id provider="uniprot">119089</id>\r
1691                             <scientific_name>Chromadorea</scientific_name>\r
1692                             <rank>class</rank>\r
1693                           </taxonomy>\r
1694                           <clade>\r
1695                             <name>LIN44_CAEEL/62-339</name>\r
1696                             <branch_length>0.12154</branch_length>\r
1697                             <color>\r
1698                               <red>132</red>\r
1699                               <green>40</green>\r
1700                               <blue>122</blue>\r
1701                             </color>\r
1702                             <taxonomy>\r
1703                               <id provider="uniprot">6239</id>\r
1704                               <code>CAEEL</code>\r
1705                               <scientific_name>Caenorhabditis elegans</scientific_name>\r
1706                               <rank>species</rank>\r
1707                             </taxonomy>\r
1708                             <sequence type="protein">\r
1709                               <accession source="uniprot">Q27886</accession>\r
1710                               <name>Abnormal cell lineage protein 44</name>\r
1711                               <gene_name>lin-44</gene_name>\r
1712                               <mol_seq is_aligned="true">ALR----------SIQLACRTHPA--------TVISAFEGVQEGLQNCANRLRFQQWDCSEAGN----------------------------------IMHDPPLLRQG--FRESSLIWALSSASAAWGVATACAQGWI-DDCACNNQM--------------------GQNE-------------------------------------------------------------------------YEFGGCTHGV-QHGITASRKLLTKVG--------AVNTLLRK--VEKHNLKAGRLAIKKTLISSCKCH---GVSGSCQQKT--------------------CWK-RTATLEHITDYLVEKYAR-AKLYTDDSVV-------------------------------------------------------------------------------------------------------------------------KTTDLIYLEASPDVC-------KAKSVAGRVC-------------AWRNET---------HTQGDCDRLC--CGNGFSIRHEVVRV-KCDCE-FV-----WCCNLVCKDCIQHRWISTCN</mol_seq>\r
1713                               <annotation ref="GO:0005109">\r
1714                                 <desc>frizzled binding</desc>\r
1715                               </annotation>\r
1716                               <annotation ref="GO:0005578">\r
1717                                 <desc>proteinaceous extracellular matrix</desc>\r
1718                               </annotation>\r
1719                               <annotation ref="GO:0005615">\r
1720                                 <desc>extracellular space</desc>\r
1721                               </annotation>\r
1722                               <annotation ref="GO:0007163">\r
1723                                 <desc>establishment or maintenance of cell polarity</desc>\r
1724                               </annotation>\r
1725                               <annotation ref="GO:0016055">\r
1726                                 <desc>Wnt signaling pathway</desc>\r
1727                               </annotation>\r
1728                               <annotation ref="GO:0030182">\r
1729                                 <desc>neuron differentiation</desc>\r
1730                               </annotation>\r
1731                               <annotation ref="GO:0040025">\r
1732                                 <desc>vulval development</desc>\r
1733                               </annotation>\r
1734                               <annotation ref="GO:0040028">\r
1735                                 <desc>regulation of vulval development</desc>\r
1736                               </annotation>\r
1737                               <annotation ref="GO:0045138">\r
1738                                 <desc>tail tip morphogenesis</desc>\r
1739                               </annotation>\r
1740                               <annotation ref="GO:0046662">\r
1741                                 <desc>regulation of oviposition</desc>\r
1742                               </annotation>\r
1743                               <annotation ref="GO:0060573">\r
1744                                 <desc>cell fate specification involved in pattern specification</desc>\r
1745                               </annotation>\r
1746                               <cross_references>\r
1747                                 <accession source="CTD">171994</accession>\r
1748                                 <accession source="NextBio">873579</accession>\r
1749                               </cross_references>\r
1750                             </sequence>\r
1751                           </clade>\r
1752                           <clade>\r
1753                             <name>Q5IWQ9_PRIPA/94-384</name>\r
1754                             <branch_length>0.11121</branch_length>\r
1755                             <color>\r
1756                               <red>132</red>\r
1757                               <green>40</green>\r
1758                               <blue>122</blue>\r
1759                             </color>\r
1760                             <taxonomy>\r
1761                               <id provider="uniprot">54126</id>\r
1762                               <code>PRIPA</code>\r
1763                               <scientific_name>Pristionchus pacificus</scientific_name>\r
1764                               <common_name>Parasitic nematode</common_name>\r
1765                               <rank>species</rank>\r
1766                             </taxonomy>\r
1767                             <sequence type="protein">\r
1768                               <accession source="uniprot">Q5IWQ9</accession>\r
1769                               <name>Protein Wnt</name>\r
1770                               <gene_name>wnt</gene_name>\r
1771                               <mol_seq is_aligned="true">GCPNLLLLSRLFGHIRVECRTRPS--------TAIAAYEGIKDAMNECSSRMKFLPWDCSQTED----------------------------------IMHDPILLKYG--YKESALVWALSSAGSAWAVATACAQGWL-SDCECSKEM--------------------EEAGKH-----------------------------------------------------------------------WEWGGCSAGV-QHGITTSRKMLTRTS-------GGTNSALRK--LEKHNLKAGRLAVKKTLTSLCKCH---GVSGSCQQKT--------------------CWK-QPASMTTITKHLIEKYHK-AKVMTDEGKL-------------------------------------------------------------------------------------------------------------------------RNNDLLFLEASPDHC-------AVRGEKPRVC-------------GWRNET---------HAQGDCGRLC--CGRGFNITHEVNRY-KCDCQ-FV-----WCCQLQCNECIQHRWVSTCT</mol_seq>\r
1772                               <annotation ref="GO:0005578">\r
1773                                 <desc>proteinaceous extracellular matrix</desc>\r
1774                               </annotation>\r
1775                               <annotation ref="GO:0007275">\r
1776                                 <desc>multicellular organismal development</desc>\r
1777                               </annotation>\r
1778                               <annotation ref="GO:0016055">\r
1779                                 <desc>Wnt signaling pathway</desc>\r
1780                               </annotation>\r
1781                             </sequence>\r
1782                           </clade>\r
1783                         </clade>\r
1784                       </clade>\r
1785                       <clade>\r
1786                         <name>A5PFR0_HYDVU/21-343</name>\r
1787                         <branch_length>0.32243</branch_length>\r
1788                         <color>\r
1789                           <red>20</red>\r
1790                           <green>132</green>\r
1791                           <blue>81</blue>\r
1792                         </color>\r
1793                         <taxonomy>\r
1794                           <id provider="uniprot">6087</id>\r
1795                           <code>HYDVU</code>\r
1796                           <scientific_name>Hydra vulgaris</scientific_name>\r
1797                           <common_name>Hydra</common_name>\r
1798                           <synonym>Hydra attenuata</synonym>\r
1799                           <rank>species</rank>\r
1800                         </taxonomy>\r
1801                         <sequence type="protein">\r
1802                           <accession source="uniprot">A5PFR0</accession>\r
1803                           <name>Protein Wnt</name>\r
1804                           <gene_name>wnt-8/11</gene_name>\r
1805                           <mol_seq is_aligned="true">LCSSMAALQ----RKLHVTSKKVSP------DVVNSVILAYKDAFKNCYKNFKFERWNCPVPQAFSQ----------------------------INTPVSLTYTYPHA--TKETAYVYAIVAASILNRIVRNCRQGVY-QDLTCVKHS--------------------INGTQS-----------------------------------------------------------------------NQDESFSVNI-SNALKLVKRIIKIFDY-----KYVRDEKRKA--FNWNNSVIGLKAFTERLTTVCKCH---GLSGYCSSKT--------------------CWKSSLSSLKETAVELMTLYHG-AKKYEEQHQQSDPSTQST-------------------------------------------------------------------------------------------NVMKNFISKDVP----------NSSVLVYLTESPDYCKKNSSI-EVQGTLNREC-----------------NH---------HLDDSCKKLCSSCGYRKHSFVKTIENMQCNCK-FR-----WCCTVVCEKCVSRQISSRCS</mol_seq>\r
1806                           <annotation ref="GO:0005578">\r
1807                             <desc>proteinaceous extracellular matrix</desc>\r
1808                           </annotation>\r
1809                           <annotation ref="GO:0007275">\r
1810                             <desc>multicellular organismal development</desc>\r
1811                           </annotation>\r
1812                           <annotation ref="GO:0016055">\r
1813                             <desc>Wnt signaling pathway</desc>\r
1814                           </annotation>\r
1815                         </sequence>\r
1816                       </clade>\r
1817                     </clade>\r
1818                   </clade>\r
1819                   <clade>\r
1820                     <branch_length>0.01538</branch_length>\r
1821                     <confidence type="bootstrap">40</confidence>\r
1822                     <clade>\r
1823                       <branch_length>0.01916</branch_length>\r
1824                       <confidence type="bootstrap">89</confidence>\r
1825                       <clade>\r
1826                         <branch_length>0.08359</branch_length>\r
1827                         <confidence type="bootstrap">100</confidence>\r
1828                         <color>\r
1829                           <red>20</red>\r
1830                           <green>71</green>\r
1831                           <blue>142</blue>\r
1832                         </color>\r
1833                         <taxonomy>\r
1834                           <id provider="uniprot">117571</id>\r
1835                           <scientific_name>Euteleostomi</scientific_name>\r
1836                         </taxonomy>\r
1837                         <clade>\r
1838                           <branch_length>0.01191</branch_length>\r
1839                           <confidence type="bootstrap">54</confidence>\r
1840                           <color>\r
1841                             <red>20</red>\r
1842                             <green>71</green>\r
1843                             <blue>142</blue>\r
1844                           </color>\r
1845                           <clade>\r
1846                             <branch_length>0.01214</branch_length>\r
1847                             <confidence type="bootstrap">72</confidence>\r
1848                             <color>\r
1849                               <red>20</red>\r
1850                               <green>71</green>\r
1851                               <blue>142</blue>\r
1852                             </color>\r
1853                             <clade>\r
1854                               <branch_length>0.01495</branch_length>\r
1855                               <confidence type="bootstrap">59</confidence>\r
1856                               <color>\r
1857                                 <red>20</red>\r
1858                                 <green>71</green>\r
1859                                 <blue>142</blue>\r
1860                               </color>\r
1861                               <clade>\r
1862                                 <name>Q3L250_CHICK/18-321</name>\r
1863                                 <branch_length>0.07613</branch_length>\r
1864                                 <color>\r
1865                                   <red>20</red>\r
1866                                   <green>71</green>\r
1867                                   <blue>142</blue>\r
1868                                 </color>\r
1869                                 <taxonomy>\r
1870                                   <id provider="uniprot">9031</id>\r
1871                                   <code>CHICK</code>\r
1872                                   <scientific_name>Gallus gallus</scientific_name>\r
1873                                   <common_name>Chicken</common_name>\r
1874                                   <rank>species</rank>\r
1875                                 </taxonomy>\r
1876                                 <sequence type="protein">\r
1877                                   <accession source="uniprot">Q3L250</accession>\r
1878                                   <name>Protein Wnt</name>\r
1879                                   <gene_name>WNT9b</gene_name>\r
1880                                   <mol_seq is_aligned="true">QCDLLKLSR----KQKRLCRREPG--------LAETLRDAIRLGIMECQFQFRSERWNCSLEG--------------------------------------RTSLLKRG--FKETAFLYAVSSAALTHSLARACSAGRM-ERCTCDDSP--------------------DLENRKA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKR--------IGKDLRAK--VDIHNTNVGIKAVKNGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHEIGRLLKLRYDD-AVKVFSTTNDAVGHSELA--------------------------------------------------------------------------------------------SPQRQSHPTKHHA------SPRATDLVYVEDSPSFCRPSKYS---LGTAGRTC-------------SRE-GN--------------CDSMC--CGRGYNTQSRLVTF-SCHCQ-VQ-----WCCYVECQQCMQEEVVYSCK</mol_seq>\r
1881                                   <annotation ref="GO:0001658">\r
1882                                     <desc>branching involved in ureteric bud morphogenesis</desc>\r
1883                                   </annotation>\r
1884                                   <annotation ref="GO:0001701">\r
1885                                     <desc>in utero embryonic development</desc>\r
1886                                   </annotation>\r
1887                                   <annotation ref="GO:0001932">\r
1888                                     <desc>regulation of protein phosphorylation</desc>\r
1889                                   </annotation>\r
1890                                   <annotation ref="GO:0003339">\r
1891                                     <desc>regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis</desc>\r
1892                                   </annotation>\r
1893                                   <annotation ref="GO:0005578">\r
1894                                     <desc>proteinaceous extracellular matrix</desc>\r
1895                                   </annotation>\r
1896                                   <annotation ref="GO:0009786">\r
1897                                     <desc>regulation of asymmetric cell division</desc>\r
1898                                   </annotation>\r
1899                                   <annotation ref="GO:0030539">\r
1900                                     <desc>male genitalia development</desc>\r
1901                                   </annotation>\r
1902                                   <annotation ref="GO:0035150">\r
1903                                     <desc>regulation of tube size</desc>\r
1904                                   </annotation>\r
1905                                   <annotation ref="GO:0043085">\r
1906                                     <desc>positive regulation of catalytic activity</desc>\r
1907                                   </annotation>\r
1908                                   <annotation ref="GO:0048701">\r
1909                                     <desc>embryonic cranial skeleton morphogenesis</desc>\r
1910                                   </annotation>\r
1911                                   <annotation ref="GO:0060021">\r
1912                                     <desc>palate development</desc>\r
1913                                   </annotation>\r
1914                                   <annotation ref="GO:0060071">\r
1915                                     <desc>Wnt signaling pathway, planar cell polarity pathway</desc>\r
1916                                   </annotation>\r
1917                                   <annotation ref="GO:0061038">\r
1918                                     <desc>uterus morphogenesis</desc>\r
1919                                   </annotation>\r
1920                                   <annotation ref="GO:0061303">\r
1921                                     <desc>cornea development in camera-type eye</desc>\r
1922                                   </annotation>\r
1923                                   <annotation ref="GO:0072003">\r
1924                                     <desc>kidney rudiment formation</desc>\r
1925                                   </annotation>\r
1926                                   <annotation ref="GO:0072044">\r
1927                                     <desc>collecting duct development</desc>\r
1928                                   </annotation>\r
1929                                   <annotation ref="GO:0072046">\r
1930                                     <desc>establishment of planar polarity involved in nephron morphogenesis</desc>\r
1931                                   </annotation>\r
1932                                   <annotation ref="GO:0072170">\r
1933                                     <desc>metanephric tubule development</desc>\r
1934                                   </annotation>\r
1935                                   <annotation ref="GO:0072181">\r
1936                                     <desc>mesonephric duct formation</desc>\r
1937                                   </annotation>\r
1938                                 </sequence>\r
1939                               </clade>\r
1940                               <clade>\r
1941                                 <name>Q6ZSP0_HUMAN/73-350</name>\r
1942                                 <branch_length>0.11391</branch_length>\r
1943                                 <color>\r
1944                                   <red>20</red>\r
1945                                   <green>71</green>\r
1946                                   <blue>142</blue>\r
1947                                 </color>\r
1948                                 <taxonomy>\r
1949                                   <id provider="uniprot">9606</id>\r
1950                                   <code>HUMAN</code>\r
1951                                   <scientific_name>Homo sapiens</scientific_name>\r
1952                                   <common_name>Human</common_name>\r
1953                                   <rank>species</rank>\r
1954                                 </taxonomy>\r
1955                                 <sequence type="protein">\r
1956                                   <accession source="uniprot">Q6ZSP0</accession>\r
1957                                   <name>Protein Wnt</name>\r
1958                                   <mol_seq is_aligned="true">PPLAL--------RGRQATSKLPP--------FLSS-----PFPPSLC-------PW-----------------------------------------------VPDPG--FKETAFLYAVSSAALTHTLARACSAGRM-ERCTCDDSP--------------------GLESRQA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLSNFLGSKR--------GNKDLRAR--ADAHNTHVGIKAVKSGLRTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFRETGQVLKLRYDS-AVKVSSATNEALGRLELW--------------------------------------------------------------------------------------------APARQGSLTKGL-------APRSGDLVYMEDSPSFCRPSKYS---PGTAGRVC-------------SRE-AS--------------CSSLC--CGRGYDTQSRLVAF-SCHCQ-VQ-----WCCYVECQQCVQEELVYTCK</mol_seq>\r
1959                                   <annotation ref="GO:0005578">\r
1960                                     <desc>proteinaceous extracellular matrix</desc>\r
1961                                   </annotation>\r
1962                                   <annotation ref="GO:0007275">\r
1963                                     <desc>multicellular organismal development</desc>\r
1964                                   </annotation>\r
1965                                   <annotation ref="GO:0016055">\r
1966                                     <desc>Wnt signaling pathway</desc>\r
1967                                   </annotation>\r
1968                                 </sequence>\r
1969                               </clade>\r
1970                             </clade>\r
1971                             <clade>\r
1972                               <name>Q4S992_TETNG/27-324</name>\r
1973                               <branch_length>0.09279</branch_length>\r
1974                               <color>\r
1975                                 <red>20</red>\r
1976                                 <green>71</green>\r
1977                                 <blue>142</blue>\r
1978                               </color>\r
1979                               <taxonomy>\r
1980                                 <id provider="uniprot">99883</id>\r
1981                                 <code>TETNG</code>\r
1982                                 <scientific_name>Tetraodon nigroviridis</scientific_name>\r
1983                                 <common_name>Spotted green pufferfish</common_name>\r
1984                                 <synonym>Chelonodon nigroviridis</synonym>\r
1985                                 <rank>species</rank>\r
1986                               </taxonomy>\r
1987                               <sequence type="protein">\r
1988                                 <accession source="uniprot">Q4S992</accession>\r
1989                                 <name>Protein Wnt</name>\r
1990                                 <mol_seq is_aligned="true">QCEQMSLSR----RQKRLCRREPG--------LAETLRESVRLSLLECRYQFRNERWNCSLDG--------------------------------------RGSLLKRA--FKETAFLLAVSSAALTHALAKACSSGRM-ERCTCDESP--------------------GIQHREA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKK--------VSKDLRAQ--VDAQNINVGVRAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLAPFHDTGRLLKYRYDN-AVRVLSVTNAATGETELA--------------------------------------------------------------------------------------------GPRRHSQNL------------RTTDLVYLEESPSFCRASRYS---PGTGGRSC-------------AKD-TS--------------CQSLC--CGRGYNTAMHLTSL-SCHCQ-VR-----WCCHVECQTCVREEEVYTCK</mol_seq>\r
1991                                 <annotation ref="GO:0005578">\r
1992                                   <desc>proteinaceous extracellular matrix</desc>\r
1993                                 </annotation>\r
1994                                 <annotation ref="GO:0007275">\r
1995                                   <desc>multicellular organismal development</desc>\r
1996                                 </annotation>\r
1997                                 <annotation ref="GO:0016055">\r
1998                                   <desc>Wnt signaling pathway</desc>\r
1999                                 </annotation>\r
2000                               </sequence>\r
2001                             </clade>\r
2002                           </clade>\r
2003                           <clade>\r
2004                             <name>A4ZGP2_XENTR/59-356</name>\r
2005                             <branch_length>0.09489</branch_length>\r
2006                             <color>\r
2007                               <red>20</red>\r
2008                               <green>71</green>\r
2009                               <blue>142</blue>\r
2010                             </color>\r
2011                             <taxonomy>\r
2012                               <id provider="uniprot">8364</id>\r
2013                               <code>XENTR</code>\r
2014                               <scientific_name>Xenopus tropicalis</scientific_name>\r
2015                               <common_name>Western clawed frog</common_name>\r
2016                               <synonym>Silurana tropicalis</synonym>\r
2017                               <rank>species</rank>\r
2018                             </taxonomy>\r
2019                             <sequence type="protein">\r
2020                               <accession source="uniprot">A4ZGP2</accession>\r
2021                               <name>Protein Wnt</name>\r
2022                               <gene_name>wnt9b</gene_name>\r
2023                               <mol_seq is_aligned="true">QCDLLPLTR----RQRRLCRKEPG--------LAEALREAVRLGVVECQFQLRSERWNCSLQE--------------------------------------RGNLLKRG--FKETAFMYAISAASLTHSLAKACSGGRM-ERCTCDDSQ--------------------GLESQQA----------------------------------------------------------------------WQWGVCGDNL-RHSTRFLQNFLRQKK--------GGRDARAK--MDLHNSNAGIKAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHETGALLKAKYEN-AIKIHGASNEAVGGHE----------------------------------------------------------------------------------------------SLGHTFGGRHA----------RSTDFLYLEESPNFCRPSRFS---PGTAGRTC-------------LRE-NT--------------CDSLC--CGRGYNIQTRMVTF-SCHCQ-VH-----WCCHVECQKCVQQQETYTCK</mol_seq>\r
2024                               <annotation ref="GO:0005578">\r
2025                                 <desc>proteinaceous extracellular matrix</desc>\r
2026                               </annotation>\r
2027                               <annotation ref="GO:0007275">\r
2028                                 <desc>multicellular organismal development</desc>\r
2029                               </annotation>\r
2030                               <annotation ref="GO:0016055">\r
2031                                 <desc>Wnt signaling pathway</desc>\r
2032                               </annotation>\r
2033                               <cross_references>\r
2034                                 <accession source="CTD">7484</accession>\r
2035                                 <accession source="KEGG">xtr:100125200</accession>\r
2036                               </cross_references>\r
2037                             </sequence>\r
2038                           </clade>\r
2039                         </clade>\r
2040                         <clade>\r
2041                           <name>WNT9A_HUMAN/58-364</name>\r
2042                           <branch_length>0.12754</branch_length>\r
2043                           <color>\r
2044                             <red>20</red>\r
2045                             <green>71</green>\r
2046                             <blue>142</blue>\r
2047                           </color>\r
2048                           <taxonomy>\r
2049                             <id provider="uniprot">9606</id>\r
2050                             <code>HUMAN</code>\r
2051                             <scientific_name>Homo sapiens</scientific_name>\r
2052                             <common_name>Human</common_name>\r
2053                             <rank>species</rank>\r
2054                           </taxonomy>\r
2055                           <sequence type="protein">\r
2056                             <accession source="uniprot">O14904</accession>\r
2057                             <name>Protein Wnt-9a</name>\r
2058                             <gene_name>WNT9A</gene_name>\r
2059                             <mol_seq is_aligned="true">ACDRLKLER----KQRRMCRRDPG--------VAETLVEAVSMSALECQFQFRFERWNCTLEG------------------------------------RYRASLLKRG--FKETAFLYAISSAGLTHALAKACSAGRM-ERCTCDEAP--------------------DLENREA----------------------------------------------------------------------WQWGGCGDNL-KYSSKFVKEFLGRRS---------SKDLRAR--VDFHNNLVGVKVIKAGVETTCKCH---GVSGSCTVRT--------------------CWR-QLAPFHEVGKHLKHKYET-ALKVGSTTNEAAGEAGAI--------------------------------------------------------------------------------------------SPPRGRASGAGGSD----PLPRTPELVHLDDSPSFCLAGRFS---PGTAGRRC-------------HRE-KN--------------CESIC--CGRGHNTQSRVVTR-PCQCQ-VR-----WCCYVECRQCTQREEVYTCK</mol_seq>\r
2060                             <annotation ref="GO:0005109">\r
2061                               <desc>frizzled binding</desc>\r
2062                             </annotation>\r
2063                             <annotation ref="GO:0005576">\r
2064                               <desc>extracellular region</desc>\r
2065                             </annotation>\r
2066                             <annotation ref="GO:0005578">\r
2067                               <desc>proteinaceous extracellular matrix</desc>\r
2068                             </annotation>\r
2069                             <annotation ref="GO:0005615">\r
2070                               <desc>extracellular space</desc>\r
2071                             </annotation>\r
2072                             <annotation ref="GO:0007093">\r
2073                               <desc>mitotic cell cycle checkpoint</desc>\r
2074                             </annotation>\r
2075                             <annotation ref="GO:0007267">\r
2076                               <desc>cell-cell signaling</desc>\r
2077                             </annotation>\r
2078                             <annotation ref="GO:0007275">\r
2079                               <desc>multicellular organismal development</desc>\r
2080                             </annotation>\r
2081                             <annotation ref="GO:0008285">\r
2082                               <desc>negative regulation of cell proliferation</desc>\r
2083                             </annotation>\r
2084                             <annotation ref="GO:0016055">\r
2085                               <desc>Wnt signaling pathway</desc>\r
2086                             </annotation>\r
2087                             <annotation ref="GO:0030182">\r
2088                               <desc>neuron differentiation</desc>\r
2089                             </annotation>\r
2090                             <annotation ref="GO:0032331">\r
2091                               <desc>negative regulation of chondrocyte differentiation</desc>\r
2092                             </annotation>\r
2093                             <annotation ref="GO:0035115">\r
2094                               <desc>embryonic forelimb morphogenesis</desc>\r
2095                             </annotation>\r
2096                             <annotation ref="GO:0043154">\r
2097                               <desc>negative regulation of cysteine-type endopeptidase activity involved in apoptotic process</desc>\r
2098                             </annotation>\r
2099                             <annotation ref="GO:0045165">\r
2100                               <desc>cell fate commitment</desc>\r
2101                             </annotation>\r
2102                             <annotation ref="GO:0045597">\r
2103                               <desc>positive regulation of cell differentiation</desc>\r
2104                             </annotation>\r
2105                             <annotation ref="GO:0045880">\r
2106                               <desc>positive regulation of smoothened signaling pathway</desc>\r
2107                             </annotation>\r
2108                             <annotation ref="GO:0048704">\r
2109                               <desc>embryonic skeletal system morphogenesis</desc>\r
2110                             </annotation>\r
2111                             <annotation ref="GO:0060070">\r
2112                               <desc>canonical Wnt signaling pathway</desc>\r
2113                             </annotation>\r
2114                             <annotation ref="GO:0060548">\r
2115                               <desc>negative regulation of cell death</desc>\r
2116                             </annotation>\r
2117                             <annotation ref="GO:0061037">\r
2118                               <desc>negative regulation of cartilage development</desc>\r
2119                             </annotation>\r
2120                             <annotation ref="GO:0061072">\r
2121                               <desc>iris morphogenesis</desc>\r
2122                             </annotation>\r
2123                             <annotation ref="GO:0061303">\r
2124                               <desc>cornea development in camera-type eye</desc>\r
2125                             </annotation>\r
2126                             <annotation ref="GO:0071300">\r
2127                               <desc>cellular response to retinoic acid</desc>\r
2128                             </annotation>\r
2129                             <annotation ref="GO:0072498">\r
2130                               <desc>embryonic skeletal joint development</desc>\r
2131                             </annotation>\r
2132                             <cross_references>\r
2133                               <accession source="CTD">7483</accession>\r
2134                               <accession source="KEGG">hsa:7483</accession>\r
2135                               <accession source="MIM">602863</accession>\r
2136                               <accession source="NextBio">29314</accession>\r
2137                               <accession source="PharmGKB">PA37379</accession>\r
2138                             </cross_references>\r
2139                           </sequence>\r
2140                         </clade>\r
2141                       </clade>\r
2142                       <clade>\r
2143                         <branch_length>0.12838</branch_length>\r
2144                         <confidence type="bootstrap">100</confidence>\r
2145                         <color>\r
2146                           <red>0</red>\r
2147                           <green>173</green>\r
2148                           <blue>193</blue>\r
2149                         </color>\r
2150                         <taxonomy>\r
2151                           <id provider="uniprot">7147</id>\r
2152                           <scientific_name>Diptera</scientific_name>\r
2153                           <rank>order</rank>\r
2154                         </taxonomy>\r
2155                         <clade>\r
2156                           <name>Q16S11_AEDAE/58-352</name>\r
2157                           <branch_length>0.08512</branch_length>\r
2158                           <color>\r
2159                             <red>0</red>\r
2160                             <green>173</green>\r
2161                             <blue>193</blue>\r
2162                           </color>\r
2163                           <taxonomy>\r
2164                             <id provider="uniprot">7159</id>\r
2165                             <code>AEDAE</code>\r
2166                             <scientific_name>Aedes aegypti</scientific_name>\r
2167                             <common_name>Yellowfever mosquito</common_name>\r
2168                             <synonym>Culex aegypti</synonym>\r
2169                             <rank>species</rank>\r
2170                           </taxonomy>\r
2171                           <sequence type="protein">\r
2172                             <accession source="uniprot">Q16S11</accession>\r
2173                             <name>Protein Wnt</name>\r
2174                             <mol_seq is_aligned="true">PCRFLSGTR----RQNHQCRRDTG--------LPDAIKEARRLAVTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKV--YRETAFVHALTAAAITYSVARACAEGKM-AKCQCASEK--------------------RPEATRLA---------------------------------------------------------------------WKWGGCSDNI-KHGKRVTRNFLELQP--------ADGDPVAE--MLRHDSEVGIQAVTSTMNDRCKCH---GVSGSCSLKT--------------------CWR-KLGDFNATAAMLRTKYHH-AIRKIPINNKTSRRAI----------------------------------------------------------------------------------------------PKEFRE--REG----------SYDQLFYFETSPTFCSV---------TRGRRC-------------LHP-DN--------------CATLC--CGRGYTTKVVKTIE-KCRCR-FTN---GRCCQIVCDYCEKYEDRYYCK</mol_seq>\r
2175                             <annotation ref="GO:0005578">\r
2176                               <desc>proteinaceous extracellular matrix</desc>\r
2177                             </annotation>\r
2178                             <annotation ref="GO:0007275">\r
2179                               <desc>multicellular organismal development</desc>\r
2180                             </annotation>\r
2181                             <annotation ref="GO:0016055">\r
2182                               <desc>Wnt signaling pathway</desc>\r
2183                             </annotation>\r
2184                           </sequence>\r
2185                         </clade>\r
2186                         <clade>\r
2187                           <name>WNT4_DROME/239-539</name>\r
2188                           <branch_length>0.10493</branch_length>\r
2189                           <color>\r
2190                             <red>0</red>\r
2191                             <green>173</green>\r
2192                             <blue>193</blue>\r
2193                           </color>\r
2194                           <taxonomy>\r
2195                             <id provider="uniprot">7227</id>\r
2196                             <code>DROME</code>\r
2197                             <scientific_name>Drosophila melanogaster</scientific_name>\r
2198                             <common_name>Fruit fly</common_name>\r
2199                             <rank>species</rank>\r
2200                           </taxonomy>\r
2201                           <sequence type="protein">\r
2202                             <accession source="uniprot">P40589</accession>\r
2203                             <name>Protein Wnt-4</name>\r
2204                             <gene_name>Wnt4</gene_name>\r
2205                             <mol_seq is_aligned="true">PCRYMPATR----RQNHQCRKETG--------LPGTLSEARRLATTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKL--YKETAFVHALTAAAMTHSIARACAEGRM-TKCSCGPKK--------------------HNREAQD----------------------------------------------------------------------FQWGGCNDNL-KHGKRVTRSFLDLRG--------GDGDEVSE--ILRHDSEVGIEAVSSQMMDKCKCH---GVSGSCSMKT--------------------CWK-KMADFNATATLLRQKYNE-AIRKAPNQRSMRQVSSSRM----------------------------------------------------------------------K-------------------KPKQRRKKPQQS----------QYTTLYYLETSPSYCAV---------TKDRQC-------------LHP-DN--------------CGTLC--CGRGYTTQVVKQVE-KCRCR-FNN---GRCCQLICDYCQRLENKYFCK</mol_seq>\r
2206                             <annotation ref="GO:0001737">\r
2207                               <desc>establishment of imaginal disc-derived wing hair orientation</desc>\r
2208                             </annotation>\r
2209                             <annotation ref="GO:0003407">\r
2210                               <desc>neural retina development</desc>\r
2211                             </annotation>\r
2212                             <annotation ref="GO:0004871">\r
2213                               <desc>signal transducer activity</desc>\r
2214                             </annotation>\r
2215                             <annotation ref="GO:0005109">\r
2216                               <desc>frizzled binding</desc>\r
2217                             </annotation>\r
2218                             <annotation ref="GO:0005515">\r
2219                               <desc>protein binding</desc>\r
2220                             </annotation>\r
2221                             <annotation ref="GO:0005576">\r
2222                               <desc>extracellular region</desc>\r
2223                             </annotation>\r
2224                             <annotation ref="GO:0005578">\r
2225                               <desc>proteinaceous extracellular matrix</desc>\r
2226                             </annotation>\r
2227                             <annotation ref="GO:0005615">\r
2228                               <desc>extracellular space</desc>\r
2229                             </annotation>\r
2230                             <annotation ref="GO:0006928">\r
2231                               <desc>cellular component movement</desc>\r
2232                             </annotation>\r
2233                             <annotation ref="GO:0007435">\r
2234                               <desc>salivary gland morphogenesis</desc>\r
2235                             </annotation>\r
2236                             <annotation ref="GO:0008045">\r
2237                               <desc>motor neuron axon guidance</desc>\r
2238                             </annotation>\r
2239                             <annotation ref="GO:0008585">\r
2240                               <desc>female gonad development</desc>\r
2241                             </annotation>\r
2242                             <annotation ref="GO:0009986">\r
2243                               <desc>cell surface</desc>\r
2244                             </annotation>\r
2245                             <annotation ref="GO:0016055">\r
2246                               <desc>Wnt signaling pathway</desc>\r
2247                             </annotation>\r
2248                             <annotation ref="GO:0016201">\r
2249                               <desc>synaptic target inhibition</desc>\r
2250                             </annotation>\r
2251                             <annotation ref="GO:0016477">\r
2252                               <desc>cell migration</desc>\r
2253                             </annotation>\r
2254                             <annotation ref="GO:0031290">\r
2255                               <desc>retinal ganglion cell axon guidance</desc>\r
2256                             </annotation>\r
2257                             <annotation ref="GO:0035206">\r
2258                               <desc>regulation of hemocyte proliferation</desc>\r
2259                             </annotation>\r
2260                             <annotation ref="GO:0035567">\r
2261                               <desc>non-canonical Wnt signaling pathway</desc>\r
2262                             </annotation>\r
2263                             <annotation ref="GO:0045165">\r
2264                               <desc>cell fate commitment</desc>\r
2265                             </annotation>\r
2266                             <annotation ref="GO:0048041">\r
2267                               <desc>focal adhesion assembly</desc>\r
2268                             </annotation>\r
2269                             <annotation ref="GO:0060071">\r
2270                               <desc>Wnt signaling pathway, planar cell polarity pathway</desc>\r
2271                             </annotation>\r
2272                             <cross_references>\r
2273                               <accession source="CTD">54361</accession>\r
2274                               <accession source="NextBio">786401</accession>\r
2275                             </cross_references>\r
2276                           </sequence>\r
2277                         </clade>\r
2278                       </clade>\r
2279                     </clade>\r
2280                     <clade>\r
2281                       <name>MOM2_CAEEL/44-362</name>\r
2282                       <branch_length>0.27468</branch_length>\r
2283                       <color>\r
2284                         <red>132</red>\r
2285                         <green>40</green>\r
2286                         <blue>122</blue>\r
2287                       </color>\r
2288                       <taxonomy>\r
2289                         <id provider="uniprot">6239</id>\r
2290                         <code>CAEEL</code>\r
2291                         <scientific_name>Caenorhabditis elegans</scientific_name>\r
2292                         <rank>species</rank>\r
2293                       </taxonomy>\r
2294                       <sequence type="protein">\r
2295                         <accession source="uniprot">Q10459</accession>\r
2296                         <name>Protein mom-2</name>\r
2297                         <gene_name>mom-2</gene_name>\r
2298                         <mol_seq is_aligned="true">LCKNVPGLT---PQQKRMCHENPN--------IIKYLISGLRSALHTCEYTFQREAWNCTLTL-----------------------------------PGVGTSPLQIA--SRESAYVYAISAAGVSHSLARACSKGLI-DDCGCGETPQGSGS---------VAVSQASSRSSSD----------------------------------------------------------------------FVWAGCSDNV-KFGNTFGRKFVDQYDR------QHATEPRSQ--MNLHNNRVGRRLLVNAMNKECKCH---GVSGSCVTKT--------------------CWK-VMPKFDEFASRLHQKYQL-AKLVTNNDQKLTVRSSP---------------------------------------------------------------------------------------------SAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKD--------REC-------------GEN-----------------CPNIC--CGRGWRTTREIVDE-PCHCQ-FV-----WCCEVKCKTCKKLVERNYCL</mol_seq>\r
2299                         <annotation ref="GO:0000132">\r
2300                           <desc>establishment of mitotic spindle orientation</desc>\r
2301                         </annotation>\r
2302                         <annotation ref="GO:0001714">\r
2303                           <desc>endodermal cell fate specification</desc>\r
2304                         </annotation>\r
2305                         <annotation ref="GO:0005109">\r
2306                           <desc>frizzled binding</desc>\r
2307                         </annotation>\r
2308                         <annotation ref="GO:0005576">\r
2309                           <desc>extracellular region</desc>\r
2310                         </annotation>\r
2311                         <annotation ref="GO:0005578">\r
2312                           <desc>proteinaceous extracellular matrix</desc>\r
2313                         </annotation>\r
2314                         <annotation ref="GO:0005615">\r
2315                           <desc>extracellular space</desc>\r
2316                         </annotation>\r
2317                         <annotation ref="GO:0016055">\r
2318                           <desc>Wnt signaling pathway</desc>\r
2319                         </annotation>\r
2320                         <annotation ref="GO:0030010">\r
2321                           <desc>establishment of cell polarity</desc>\r
2322                         </annotation>\r
2323                         <annotation ref="GO:0030182">\r
2324                           <desc>neuron differentiation</desc>\r
2325                         </annotation>\r
2326                         <annotation ref="GO:0030971">\r
2327                           <desc>receptor tyrosine kinase binding</desc>\r
2328                         </annotation>\r
2329                         <annotation ref="GO:0045167">\r
2330                           <desc>asymmetric protein localization involved in cell fate determination</desc>\r
2331                         </annotation>\r
2332                         <annotation ref="GO:0048598">\r
2333                           <desc>embryonic morphogenesis</desc>\r
2334                         </annotation>\r
2335                         <cross_references>\r
2336                           <accession source="CTD">179217</accession>\r
2337                           <accession source="NextBio">904422</accession>\r
2338                         </cross_references>\r
2339                       </sequence>\r
2340                     </clade>\r
2341                   </clade>\r
2342                 </clade>\r
2343                 <clade>\r
2344                   <name>Q589S1_DUGJA/51-361</name>\r
2345                   <branch_length>0.24548</branch_length>\r
2346                   <color>\r
2347                     <red>153</red>\r
2348                     <green>112</green>\r
2349                     <blue>0</blue>\r
2350                   </color>\r
2351                   <taxonomy>\r
2352                     <id provider="uniprot">6161</id>\r
2353                     <code>DUGJA</code>\r
2354                     <scientific_name>Dugesia japonica</scientific_name>\r
2355                     <common_name>Planarian</common_name>\r
2356                     <rank>species</rank>\r
2357                   </taxonomy>\r
2358                   <sequence type="protein">\r
2359                     <accession source="uniprot">Q589S1</accession>\r
2360                     <name>Protein Wnt</name>\r
2361                     <gene_name>DjwntB</gene_name>\r
2362                     <mol_seq is_aligned="true">ICPMIFEES---SKEKNLCLTYPN--------MMVSIVYGAKLGLVECAQQFKFERWNCTFNESFPN-----------------------------MMTHHLHEMTVRS--VKETAFLFSIWSSGVVYSITNSCSKGDL-KECYCDPQR--------------------HGQDKDGSG-------------------------------------------------------------------DFTWGGCSDHI-KFGMKVSTIFLDNHD-------RKDQTGRSL--MNQHNNRVGRRVVWKTRLKKCKCH---GVSGACSLRT--------------------CWQ-RMNDFRRIGDMLKKLYNK-PQKVSYNPFQKS--------------------------------------------------------------------------------------------------LTFSRNQFRRP----------SKKRLVYIEQSQDYCIQDLTI-GHPGTGGREC-------------NYT-SS---------QHDS-CSELC--CNRGHYAYEMVVEE-NCDCK-FF-----WCCEVDAKYAGER---YSCI</mol_seq>\r
2363                     <annotation ref="GO:0005578">\r
2364                       <desc>proteinaceous extracellular matrix</desc>\r
2365                     </annotation>\r
2366                     <annotation ref="GO:0007275">\r
2367                       <desc>multicellular organismal development</desc>\r
2368                     </annotation>\r
2369                     <annotation ref="GO:0016055">\r
2370                       <desc>Wnt signaling pathway</desc>\r
2371                     </annotation>\r
2372                   </sequence>\r
2373                 </clade>\r
2374               </clade>\r
2375             </clade>\r
2376             <clade>\r
2377               <branch_length>0.00547</branch_length>\r
2378               <confidence type="bootstrap">3</confidence>\r
2379               <clade>\r
2380                 <branch_length>0.006</branch_length>\r
2381                 <confidence type="bootstrap">7</confidence>\r
2382                 <clade>\r
2383                   <branch_length>0.03522</branch_length>\r
2384                   <confidence type="bootstrap">55</confidence>\r
2385                   <clade>\r
2386                     <branch_length>0.07607</branch_length>\r
2387                     <confidence type="bootstrap">100</confidence>\r
2388                     <clade>\r
2389                       <branch_length>0.07054</branch_length>\r
2390                       <confidence type="bootstrap">100</confidence>\r
2391                       <color>\r
2392                         <red>20</red>\r
2393                         <green>71</green>\r
2394                         <blue>142</blue>\r
2395                       </color>\r
2396                       <taxonomy>\r
2397                         <id provider="uniprot">117571</id>\r
2398                         <scientific_name>Euteleostomi</scientific_name>\r
2399                       </taxonomy>\r
2400                       <clade>\r
2401                         <branch_length>0.03271</branch_length>\r
2402                         <confidence type="bootstrap">96</confidence>\r
2403                         <color>\r
2404                           <red>20</red>\r
2405                           <green>71</green>\r
2406                           <blue>142</blue>\r
2407                         </color>\r
2408                         <clade>\r
2409                           <branch_length>0.01268</branch_length>\r
2410                           <confidence type="bootstrap">86</confidence>\r
2411                           <color>\r
2412                             <red>20</red>\r
2413                             <green>71</green>\r
2414                             <blue>142</blue>\r
2415                           </color>\r
2416                           <clade>\r
2417                             <branch_length>0.12585</branch_length>\r
2418                             <confidence type="bootstrap">100</confidence>\r
2419                             <color>\r
2420                               <red>20</red>\r
2421                               <green>71</green>\r
2422                               <blue>142</blue>\r
2423                             </color>\r
2424                             <taxonomy>\r
2425                               <id provider="uniprot">32443</id>\r
2426                               <scientific_name>Teleostei</scientific_name>\r
2427                               <rank>infraclass</rank>\r
2428                             </taxonomy>\r
2429                             <clade>\r
2430                               <name>WN10B_DANRE/47-427</name>\r
2431                               <branch_length>0.07866</branch_length>\r
2432                               <color>\r
2433                                 <red>20</red>\r
2434                                 <green>71</green>\r
2435                                 <blue>142</blue>\r
2436                               </color>\r
2437                               <taxonomy>\r
2438                                 <id provider="uniprot">7955</id>\r
2439                                 <code>DANRE</code>\r
2440                                 <scientific_name>Danio rerio</scientific_name>\r
2441                                 <common_name>Zebrafish</common_name>\r
2442                                 <synonym>Brachydanio rerio</synonym>\r
2443                                 <rank>species</rank>\r
2444                               </taxonomy>\r
2445                               <sequence type="protein">\r
2446                                 <accession source="uniprot">Q801F7</accession>\r
2447                                 <name>Protein Wnt-10b</name>\r
2448                                 <gene_name>wnt10b</gene_name>\r
2449                                 <mol_seq is_aligned="true">VCLRLAGLT---KKQMRLCVRSPD--------VTASALQGIQVAIHECQHQLRDQRWNCSSLENHG-------------------------------KLPHQSAILNRG--FRESAFSLSLLAAGVVHSVASACSLGKL-RGCGCEAKR--------------------RLDDDKIRLKLTQLQLQTFQRSGVSLAGAGENTPELSS--------LHGSLPANLHSSHPMSLLKPLPDEVTMLQDTWEWGGCSHDI-RFGVRFSRDWLDSRG--------SPRDIHAR--TRIHNNRVGRQVVTDNMRRKCKCH---GTSGSCQFKT--------------------CWY-VSPEFRLVGSLLREKFLT-AIFINSQNKNNGVFNSRTGGST----------------------------------------------------------------GSDP-L----------------RGQRRRS----------------ISRELVYFEKSPDFCDREPAV-DSLGTQGRIC-------------NKS-SP---------GMDG-CGSLC--CGRGHNILKQARSE-RCHCR-FH-----WCCYVLCEECKVTEWVNVCK</mol_seq>\r
2450                                 <annotation ref="GO:0005109">\r
2451                                   <desc>frizzled binding</desc>\r
2452                                 </annotation>\r
2453                                 <annotation ref="GO:0005578">\r
2454                                   <desc>proteinaceous extracellular matrix</desc>\r
2455                                 </annotation>\r
2456                                 <annotation ref="GO:0005615">\r
2457                                   <desc>extracellular space</desc>\r
2458                                 </annotation>\r
2459                                 <annotation ref="GO:0016055">\r
2460                                   <desc>Wnt signaling pathway</desc>\r
2461                                 </annotation>\r
2462                                 <annotation ref="GO:0030182">\r
2463                                   <desc>neuron differentiation</desc>\r
2464                                 </annotation>\r
2465                                 <annotation ref="GO:0030917">\r
2466                                   <desc>midbrain-hindbrain boundary development</desc>\r
2467                                 </annotation>\r
2468                                 <annotation ref="GO:0045165">\r
2469                                   <desc>cell fate commitment</desc>\r
2470                                 </annotation>\r
2471                                 <annotation ref="GO:0060070">\r
2472                                   <desc>canonical Wnt signaling pathway</desc>\r
2473                                 </annotation>\r
2474                                 <cross_references>\r
2475                                   <accession source="CTD">7480</accession>\r
2476                                   <accession source="KEGG">dre:30308</accession>\r
2477                                   <accession source="NextBio">20806749</accession>\r
2478                                 </cross_references>\r
2479                               </sequence>\r
2480                             </clade>\r
2481                             <clade>\r
2482                               <name>Q4RW24_TETNG/23-401</name>\r
2483                               <branch_length>0.06698</branch_length>\r
2484                               <color>\r
2485                                 <red>20</red>\r
2486                                 <green>71</green>\r
2487                                 <blue>142</blue>\r
2488                               </color>\r
2489                               <taxonomy>\r
2490                                 <id provider="uniprot">99883</id>\r
2491                                 <code>TETNG</code>\r
2492                                 <scientific_name>Tetraodon nigroviridis</scientific_name>\r
2493                                 <common_name>Spotted green pufferfish</common_name>\r
2494                                 <synonym>Chelonodon nigroviridis</synonym>\r
2495                                 <rank>species</rank>\r
2496                               </taxonomy>\r
2497                               <sequence type="protein">\r
2498                                 <accession source="uniprot">Q4RW24</accession>\r
2499                                 <name>Protein Wnt</name>\r
2500                                 <mol_seq is_aligned="true">VCLKLAGLS---KRQMRMCVRSPD--------ATASALQGIQVAIHECQYQLRDQRWNCSSLEGLG-------------------------------KVPHHNTILNRG--FRESAFSLAMLAAGVAHSVASACSMGKL-RGCGCEAKR--------------------RQDDDKIRLKLTQLQLQTLQKGGVGFGVTQSLSSELSG--------HHRDLPTNLRSTHPSGLLKPLPDDLSSLQETWEWGGCSHDV-RFGDRFSRDWLNSRG--------SPRDIHAR--MKIHNNRVGRQVVTDNMKRKCKCH---GTSGSCQFKT--------------------CWH-VSPEFRLVGSLLKEKFLS-AILVNSQNKNNGVFNSRNGVS------------------------------------------------------------------GST-G----------------GPGRRRS----------------MSRELVYFEKSPDFCERDSSV-DSAGTQGRIC-------------NKT-SH---------GTDS-CGSLC--CGRGHNILKKTQSE-RCNCR-FH-----WCCYVLCEECHLTEWVNVCK</mol_seq>\r
2501                                 <annotation ref="GO:0005578">\r
2502                                   <desc>proteinaceous extracellular matrix</desc>\r
2503                                 </annotation>\r
2504                                 <annotation ref="GO:0007275">\r
2505                                   <desc>multicellular organismal development</desc>\r
2506                                 </annotation>\r
2507                                 <annotation ref="GO:0016055">\r
2508                                   <desc>Wnt signaling pathway</desc>\r
2509                                 </annotation>\r
2510                               </sequence>\r
2511                             </clade>\r
2512                           </clade>\r
2513                           <clade>\r
2514                             <name>A0JMB0_XENTR/45-388</name>\r
2515                             <branch_length>0.08158</branch_length>\r
2516                             <color>\r
2517                               <red>20</red>\r
2518                               <green>71</green>\r
2519                               <blue>142</blue>\r
2520                             </color>\r
2521                             <taxonomy>\r
2522                               <id provider="uniprot">8364</id>\r
2523                               <code>XENTR</code>\r
2524                               <scientific_name>Xenopus tropicalis</scientific_name>\r
2525                               <common_name>Western clawed frog</common_name>\r
2526                               <synonym>Silurana tropicalis</synonym>\r
2527                               <rank>species</rank>\r
2528                             </taxonomy>\r
2529                             <sequence type="protein">\r
2530                               <accession source="uniprot">A0JMB0</accession>\r
2531                               <name>Protein Wnt</name>\r
2532                               <gene_name>wnt10b</gene_name>\r
2533                               <mol_seq is_aligned="true">VCLTLPGLS---KRQMGLCVRNPD--------VTASALQGIQIAIHECQHQLKGQRWNCSTLETMG-------------------------------KMPHDSAILKRG--FRESAFAFSLLAAGVMHSVATACSLGKL-QGCGCEWKR--------------------RGTEEKIRLKLNQLQLQALSKVKGLP---------------------------------RDLTPLLRETPEPSPQDTWEWGGCKHEL-EFGEKFSRDFLDSRE--------SPRDIHAR--MRIHNNRVGRQAVTENMKRRCKCH---GTSGSCQFKT--------------------CWH-VTPDFRAVGTLMRDKLQR-AVFVNSRNKNSGAFHPR---------------------------------------------------------------------------------------------LNKKR----------------LAKELVYFEKSPDFCEKDPRV-DSPGTQGRVC-------------NKT-SQ---------QMDN-CASLC--CGRGHNILMQTRRE-RCNCR-FH-----WCCYVMCEECRVTQLVNVCK</mol_seq>\r
2534                               <annotation ref="GO:0005578">\r
2535                                 <desc>proteinaceous extracellular matrix</desc>\r
2536                               </annotation>\r
2537                               <annotation ref="GO:0007275">\r
2538                                 <desc>multicellular organismal development</desc>\r
2539                               </annotation>\r
2540                               <annotation ref="GO:0016055">\r
2541                                 <desc>Wnt signaling pathway</desc>\r
2542                               </annotation>\r
2543                               <cross_references>\r
2544                                 <accession source="CTD">7480</accession>\r
2545                                 <accession source="KEGG">xtr:780228</accession>\r
2546                               </cross_references>\r
2547                             </sequence>\r
2548                           </clade>\r
2549                         </clade>\r
2550                         <clade>\r
2551                           <name>WN10B_HUMAN/47-389</name>\r
2552                           <branch_length>0.08989</branch_length>\r
2553                           <color>\r
2554                             <red>20</red>\r
2555                             <green>71</green>\r
2556                             <blue>142</blue>\r
2557                           </color>\r
2558                           <taxonomy>\r
2559                             <id provider="uniprot">9606</id>\r
2560                             <code>HUMAN</code>\r
2561                             <scientific_name>Homo sapiens</scientific_name>\r
2562                             <common_name>Human</common_name>\r
2563                             <rank>species</rank>\r
2564                           </taxonomy>\r
2565                           <sequence type="protein">\r
2566                             <accession source="uniprot">O00744</accession>\r
2567                             <name>Protein Wnt-10b</name>\r
2568                             <gene_name>WNT10B</gene_name>\r
2569                             <mol_seq is_aligned="true">VCLTLSGLS---KRQLGLCLRNPD--------VTASALQGLHIAVHECQHQLRDQRWNCSALEGGG-------------------------------RLPHHSAILKRG--FRESAFSFSMLAAGVMHAVATACSLGKL-VSCGCGWKG--------------------SGEQDRLRAKLLQLQALSRGKSFPH----------------------------------SLPSPGPGSSPSPGPQDTWEWGGCNHDM-DFGEKFSRDFLDSRE--------APRDIQAR--MRIHNNRVGRQVVTENLKRKCKCH---GTSGSCQFKT--------------------CWR-AAPEFRAVGAALRERLGR-AIFIDTHNRNSGAFQPR---------------------------------------------------------------------------------------------LRPRR----------------LSGELVYFEKSPDFCERDPTM-GSPGTRGRAC-------------NKT-SR---------LLDG-CGSLC--CGRGHNVLRQTRVE-RCHCR-FH-----WCCYVLCDECKVTEWVNVCK</mol_seq>\r
2570                             <annotation ref="GO:0000086">\r
2571                               <desc>G2/M transition of mitotic cell cycle</desc>\r
2572                             </annotation>\r
2573                             <annotation ref="GO:0000122">\r
2574                               <desc>negative regulation of transcription from RNA polymerase II promoter</desc>\r
2575                             </annotation>\r
2576                             <annotation ref="GO:0002062">\r
2577                               <desc>chondrocyte differentiation</desc>\r
2578                             </annotation>\r
2579                             <annotation ref="GO:0005109">\r
2580                               <desc>frizzled binding</desc>\r
2581                             </annotation>\r
2582                             <annotation ref="GO:0005576">\r
2583                               <desc>extracellular region</desc>\r
2584                             </annotation>\r
2585                             <annotation ref="GO:0005578">\r
2586                               <desc>proteinaceous extracellular matrix</desc>\r
2587                             </annotation>\r
2588                             <annotation ref="GO:0005615">\r
2589                               <desc>extracellular space</desc>\r
2590                             </annotation>\r
2591                             <annotation ref="GO:0006629">\r
2592                               <desc>lipid metabolic process</desc>\r
2593                             </annotation>\r
2594                             <annotation ref="GO:0007050">\r
2595                               <desc>cell cycle arrest</desc>\r
2596                             </annotation>\r
2597                             <annotation ref="GO:0007224">\r
2598                               <desc>smoothened signaling pathway</desc>\r
2599                             </annotation>\r
2600                             <annotation ref="GO:0008284">\r
2601                               <desc>positive regulation of cell proliferation</desc>\r
2602                             </annotation>\r
2603                             <annotation ref="GO:0010971">\r
2604                               <desc>positive regulation of G2/M transition of mitotic cell cycle</desc>\r
2605                             </annotation>\r
2606                             <annotation ref="GO:0014835">\r
2607                               <desc>myoblast differentiation involved in skeletal muscle regeneration</desc>\r
2608                             </annotation>\r
2609                             <annotation ref="GO:0016055">\r
2610                               <desc>Wnt signaling pathway</desc>\r
2611                             </annotation>\r
2612                             <annotation ref="GO:0030182">\r
2613                               <desc>neuron differentiation</desc>\r
2614                             </annotation>\r
2615                             <annotation ref="GO:0030501">\r
2616                               <desc>positive regulation of bone mineralization</desc>\r
2617                             </annotation>\r
2618                             <annotation ref="GO:0030858">\r
2619                               <desc>positive regulation of epithelial cell differentiation</desc>\r
2620                             </annotation>\r
2621                             <annotation ref="GO:0032434">\r
2622                               <desc>regulation of proteasomal ubiquitin-dependent protein catabolic process</desc>\r
2623                             </annotation>\r
2624                             <annotation ref="GO:0043065">\r
2625                               <desc>positive regulation of apoptotic process</desc>\r
2626                             </annotation>\r
2627                             <annotation ref="GO:0045165">\r
2628                               <desc>cell fate commitment</desc>\r
2629                             </annotation>\r
2630                             <annotation ref="GO:0045599">\r
2631                               <desc>negative regulation of fat cell differentiation</desc>\r
2632                             </annotation>\r
2633                             <annotation ref="GO:0045669">\r
2634                               <desc>positive regulation of osteoblast differentiation</desc>\r
2635                             </annotation>\r
2636                             <annotation ref="GO:0045899">\r
2637                               <desc>positive regulation of RNA polymerase II transcriptional preinitiation complex assembly</desc>\r
2638                             </annotation>\r
2639                             <annotation ref="GO:0048018">\r
2640                               <desc>receptor agonist activity</desc>\r
2641                             </annotation>\r
2642                             <annotation ref="GO:0048641">\r
2643                               <desc>regulation of skeletal muscle tissue development</desc>\r
2644                             </annotation>\r
2645                             <annotation ref="GO:0048741">\r
2646                               <desc>skeletal muscle fiber development</desc>\r
2647                             </annotation>\r
2648                             <annotation ref="GO:0050680">\r
2649                               <desc>negative regulation of epithelial cell proliferation</desc>\r
2650                             </annotation>\r
2651                             <annotation ref="GO:0050821">\r
2652                               <desc>protein stabilization</desc>\r
2653                             </annotation>\r
2654                             <annotation ref="GO:0050909">\r
2655                               <desc>sensory perception of taste</desc>\r
2656                             </annotation>\r
2657                             <annotation ref="GO:0051091">\r
2658                               <desc>positive regulation of sequence-specific DNA binding transcription factor activity</desc>\r
2659                             </annotation>\r
2660                             <annotation ref="GO:0051885">\r
2661                               <desc>positive regulation of anagen</desc>\r
2662                             </annotation>\r
2663                             <annotation ref="GO:0060070">\r
2664                               <desc>canonical Wnt signaling pathway</desc>\r
2665                             </annotation>\r
2666                             <annotation ref="GO:0060346">\r
2667                               <desc>bone trabecula formation</desc>\r
2668                             </annotation>\r
2669                             <annotation ref="GO:0061196">\r
2670                               <desc>fungiform papilla development</desc>\r
2671                             </annotation>\r
2672                             <annotation ref="GO:0071300">\r
2673                               <desc>cellular response to retinoic acid</desc>\r
2674                             </annotation>\r
2675                             <annotation ref="GO:0071320">\r
2676                               <desc>cellular response to cAMP</desc>\r
2677                             </annotation>\r
2678                             <annotation ref="GO:0071374">\r
2679                               <desc>cellular response to parathyroid hormone stimulus</desc>\r
2680                             </annotation>\r
2681                             <annotation ref="GO:0071425">\r
2682                               <desc>hematopoietic stem cell proliferation</desc>\r
2683                             </annotation>\r
2684                             <annotation ref="GO:0071464">\r
2685                               <desc>cellular response to hydrostatic pressure</desc>\r
2686                             </annotation>\r
2687                             <annotation ref="GO:0090263">\r
2688                               <desc>positive regulation of canonical Wnt signaling pathway</desc>\r
2689                             </annotation>\r
2690                             <cross_references>\r
2691                               <accession source="CTD">7480</accession>\r
2692                               <accession source="KEGG">hsa:7480</accession>\r
2693                               <accession source="MIM">225300</accession>\r
2694                               <accession source="MIM">601906</accession>\r
2695                               <accession source="NextBio">29300</accession>\r
2696                               <accession source="Orphanet" comment="Split hand-split foot malformation">2440</accession>\r
2697                               <accession source="PharmGKB">PA37377</accession>\r
2698                             </cross_references>\r
2699                           </sequence>\r
2700                         </clade>\r
2701                       </clade>\r
2702                       <clade>\r
2703                         <branch_length>0.05315</branch_length>\r
2704                         <confidence type="bootstrap">98</confidence>\r
2705                         <color>\r
2706                           <red>20</red>\r
2707                           <green>71</green>\r
2708                           <blue>142</blue>\r
2709                         </color>\r
2710                         <clade>\r
2711                           <name>Q53S44_HUMAN/60-417</name>\r
2712                           <branch_length>0.09396</branch_length>\r
2713                           <color>\r
2714                             <red>20</red>\r
2715                             <green>71</green>\r
2716                             <blue>142</blue>\r
2717                           </color>\r
2718                           <taxonomy>\r
2719                             <id provider="uniprot">9606</id>\r
2720                             <code>HUMAN</code>\r
2721                             <scientific_name>Homo sapiens</scientific_name>\r
2722                             <common_name>Human</common_name>\r
2723                             <rank>species</rank>\r
2724                           </taxonomy>\r
2725                           <sequence type="protein">\r
2726                             <accession source="uniprot">Q9GZT5</accession>\r
2727                             <name>Protein Wnt-10a</name>\r
2728                             <gene_name>WNT10A</gene_name>\r
2729                             <mol_seq is_aligned="true">VCLTLPGLS---RRQMEVCVRHPD--------VAASAIQGIQIAIHECQHQFRDQRWNCSSLETRN-------------------------------KIPYESPIFSRG--FRESAFAYAIAAAGVVHAVSNACALGKL-KACGCDASR--------------------RGDEEAFRRKLHRLQLDALQRGKGLS--------------------------------HGVPEHPALPTASPGLQDSWEWGGCSPDM-GFGERFSKDFLDSRE--------PHRDIHAR--MRLHNNRVGRQAVMENMRRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRTVGALLRSRFHR-ATLIRPHNRNGGQLEPGPAGAP---------------------------------------------------------------SPAPG-A----------------PGPRRRA----------------SPADLVYFEKSPDFCEREPRL-DSAGTVGRLC-------------NKS-SA---------GSDG-CGSMC--CGRGHNILRQTRSE-RCHCR-FH-----WCCFVVCEECRITEWVSVCK</mol_seq>\r
2730                             <annotation ref="GO:0001942">\r
2731                               <desc>hair follicle development</desc>\r
2732                             </annotation>\r
2733                             <annotation ref="GO:0005109">\r
2734                               <desc>frizzled binding</desc>\r
2735                             </annotation>\r
2736                             <annotation ref="GO:0005576">\r
2737                               <desc>extracellular region</desc>\r
2738                             </annotation>\r
2739                             <annotation ref="GO:0005578">\r
2740                               <desc>proteinaceous extracellular matrix</desc>\r
2741                             </annotation>\r
2742                             <annotation ref="GO:0005615">\r
2743                               <desc>extracellular space</desc>\r
2744                             </annotation>\r
2745                             <annotation ref="GO:0010628">\r
2746                               <desc>positive regulation of gene expression</desc>\r
2747                             </annotation>\r
2748                             <annotation ref="GO:0014033">\r
2749                               <desc>neural crest cell differentiation</desc>\r
2750                             </annotation>\r
2751                             <annotation ref="GO:0016055">\r
2752                               <desc>Wnt signaling pathway</desc>\r
2753                             </annotation>\r
2754                             <annotation ref="GO:0030182">\r
2755                               <desc>neuron differentiation</desc>\r
2756                             </annotation>\r
2757                             <annotation ref="GO:0031069">\r
2758                               <desc>hair follicle morphogenesis</desc>\r
2759                             </annotation>\r
2760                             <annotation ref="GO:0042476">\r
2761                               <desc>odontogenesis</desc>\r
2762                             </annotation>\r
2763                             <annotation ref="GO:0042487">\r
2764                               <desc>regulation of odontogenesis of dentin-containing tooth</desc>\r
2765                             </annotation>\r
2766                             <annotation ref="GO:0043586">\r
2767                               <desc>tongue development</desc>\r
2768                             </annotation>\r
2769                             <annotation ref="GO:0043588">\r
2770                               <desc>skin development</desc>\r
2771                             </annotation>\r
2772                             <annotation ref="GO:0045165">\r
2773                               <desc>cell fate commitment</desc>\r
2774                             </annotation>\r
2775                             <annotation ref="GO:0048730">\r
2776                               <desc>epidermis morphogenesis</desc>\r
2777                             </annotation>\r
2778                             <annotation ref="GO:0048733">\r
2779                               <desc>sebaceous gland development</desc>\r
2780                             </annotation>\r
2781                             <annotation ref="GO:0071560">\r
2782                               <desc>cellular response to transforming growth factor beta stimulus</desc>\r
2783                             </annotation>\r
2784                             <cross_references>\r
2785                               <accession source="CTD">80326</accession>\r
2786                               <accession source="KEGG">hsa:80326</accession>\r
2787                               <accession source="MIM">150400</accession>\r
2788                               <accession source="MIM">224750</accession>\r
2789                               <accession source="MIM">257980</accession>\r
2790                               <accession source="MIM">606268</accession>\r
2791                               <accession source="NextBio">70863</accession>\r
2792                               <accession source="Orphanet" comment="Hypodontia">2227</accession>\r
2793                               <accession source="Orphanet" comment="Autosomal recessive hypohidrotic ectodermal dysplasia">248</accession>\r
2794                               <accession source="Orphanet" comment="Odonto-onycho-dermal dysplasia">2721</accession>\r
2795                               <accession source="Orphanet" comment="Schopf-Schulz-Passarge syndrome">50944</accession>\r
2796                               <accession source="Orphanet" comment="Oligodontia">99798</accession>\r
2797                               <accession source="PharmGKB">PA37817</accession>\r
2798                             </cross_references>\r
2799                           </sequence>\r
2800                         </clade>\r
2801                         <clade>\r
2802                           <name>A4ZGN7_XENLA/44-389</name>\r
2803                           <branch_length>0.05956</branch_length>\r
2804                           <color>\r
2805                             <red>20</red>\r
2806                             <green>71</green>\r
2807                             <blue>142</blue>\r
2808                           </color>\r
2809                           <taxonomy>\r
2810                             <id provider="uniprot">8355</id>\r
2811                             <code>XENLA</code>\r
2812                             <scientific_name>Xenopus laevis</scientific_name>\r
2813                             <common_name>African clawed frog</common_name>\r
2814                             <rank>species</rank>\r
2815                           </taxonomy>\r
2816                           <sequence type="protein">\r
2817                             <accession source="uniprot">A4ZGN7</accession>\r
2818                             <name>Protein Wnt</name>\r
2819                             <gene_name>wnt10a</gene_name>\r
2820                             <mol_seq is_aligned="true">VCLTVPGLT---RRQMEVCMRHPD--------VAASAIQGIQIAIHECQYQFQDHRWNCSSLETKN-------------------------------KIPYDSAVFSRG--FRESAYVYAIAAAGVVHAVSNACSMGKL-KSCGCDEKR--------------------RGDEEAFKAKLHRLQLEAMNRGKGM----------------------------------VHGVMEHLPADPPGPQDSWEWGGCSPDV-EYGERFSKEFLDSRE--------LFRDIHAR--MRLHNNRVGRQVVTDNMKRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRIIGSLLKDRFYG-ATLIKPHNRNTGQLEQAP-----------------------------------------------------------------------V-------------------PFRRRA----------------SINDLVYFEKSPDFCEQELNL-DSAGTQGRIC-------------NKT-SP---------GLDN-CESLC--CGRGHNILRQTRSE-RCNCK-FH-----WCCYVVCEECRITEWVSVCK</mol_seq>\r
2821                             <annotation ref="GO:0005578">\r
2822                               <desc>proteinaceous extracellular matrix</desc>\r
2823                             </annotation>\r
2824                             <annotation ref="GO:0007275">\r
2825                               <desc>multicellular organismal development</desc>\r
2826                             </annotation>\r
2827                             <annotation ref="GO:0016055">\r
2828                               <desc>Wnt signaling pathway</desc>\r
2829                             </annotation>\r
2830                             <cross_references>\r
2831                               <accession source="CTD">80326</accession>\r
2832                               <accession source="KEGG">xla:100049784</accession>\r
2833                             </cross_references>\r
2834                           </sequence>\r
2835                         </clade>\r
2836                       </clade>\r
2837                     </clade>\r
2838                     <clade>\r
2839                       <branch_length>0.19929</branch_length>\r
2840                       <confidence type="bootstrap">100</confidence>\r
2841                       <color>\r
2842                         <red>0</red>\r
2843                         <green>173</green>\r
2844                         <blue>193</blue>\r
2845                       </color>\r
2846                       <taxonomy>\r
2847                         <id provider="uniprot">7147</id>\r
2848                         <scientific_name>Diptera</scientific_name>\r
2849                         <rank>order</rank>\r
2850                       </taxonomy>\r
2851                       <clade>\r
2852                         <name>Q17NQ1_AEDAE/7-386</name>\r
2853                         <branch_length>0.09394</branch_length>\r
2854                         <color>\r
2855                           <red>0</red>\r
2856                           <green>173</green>\r
2857                           <blue>193</blue>\r
2858                         </color>\r
2859                         <taxonomy>\r
2860                           <id provider="uniprot">7159</id>\r
2861                           <code>AEDAE</code>\r
2862                           <scientific_name>Aedes aegypti</scientific_name>\r
2863                           <common_name>Yellowfever mosquito</common_name>\r
2864                           <synonym>Culex aegypti</synonym>\r
2865                           <rank>species</rank>\r
2866                         </taxonomy>\r
2867                         <sequence type="protein">\r
2868                           <accession source="uniprot">Q17NQ1</accession>\r
2869                           <name>Protein Wnt</name>\r
2870                           <mol_seq is_aligned="true">TCRTVPGLT---REQLELCYRASD--------VTAAAIEGLELGVRECQHQFQWHRWNCSSLSTKS-------------------------------RNPHTSSMLKRG--YRESAFAYAVAAAGVTHSVARACAQGRL-ISCGCDPSVNRKGM---------TKSLRESLEKEKLRFLDAINENSILVD-------------------------------------------DSLKKLKTKQASRWKWGGCSHNM-AFGVEFSELFLDTRE--------KGGDIQSQ--INLHNNHAGRRAVSNNMQVRCKCH---GMSGSCQLKT--------------------CWK-SAPDFRVVGKVLKQQYRR-AVLVDQSNLGNGPPMIVYHKPKKRKHVNNV-----------------------------------------------RPPRRTKDKGQQQ-QQRH----------LIPISRANRK----------------MENALFYYQRSPNFCERDQVS-DIPGTVGRRC-------------NRT-SV---------GSDG-CASMC--CGRGYNLIREKRVD-RCNCK-FH-----WCCYVECDDCEIEEWISVCN</mol_seq>\r
2871                           <annotation ref="GO:0005578">\r
2872                             <desc>proteinaceous extracellular matrix</desc>\r
2873                           </annotation>\r
2874                           <annotation ref="GO:0007275">\r
2875                             <desc>multicellular organismal development</desc>\r
2876                           </annotation>\r
2877                           <annotation ref="GO:0016055">\r
2878                             <desc>Wnt signaling pathway</desc>\r
2879                           </annotation>\r
2880                         </sequence>\r
2881                       </clade>\r
2882                       <clade>\r
2883                         <name>Q9VM25_DROME/24-432</name>\r
2884                         <branch_length>0.22204</branch_length>\r
2885                         <color>\r
2886                           <red>0</red>\r
2887                           <green>173</green>\r
2888                           <blue>193</blue>\r
2889                         </color>\r
2890                         <taxonomy>\r
2891                           <id provider="uniprot">7227</id>\r
2892                           <code>DROME</code>\r
2893                           <scientific_name>Drosophila melanogaster</scientific_name>\r
2894                           <common_name>Fruit fly</common_name>\r
2895                           <rank>species</rank>\r
2896                         </taxonomy>\r
2897                         <sequence type="protein">\r
2898                           <accession source="uniprot">Q9VM25</accession>\r
2899                           <name>Protein Wnt</name>\r
2900                           <gene_name>Wnt10</gene_name>\r
2901                           <mol_seq is_aligned="true">TCRSVPGLT---KDQVELCYKASD--------VTAAALEGLDMAIRECQIQFQWHRWNCSSLSTKS-------------------------------RNPHASSLLKKG--YRESAFAFAISAAGVAHSVARACSQGRL-MSCGCDPTINRKTL---------NKNLRQSLDKEKKQFLQYLETNQILTP------------------------------------------EEEKKYERSKIASRWKWGGCSHNM-DFGVEYSKLFLDCRE--------KAGDIQSK--INLHNNHAGRIAVSNNMEFRCKCH---GMSGSCQLKT--------------------CWK-SAPDFHIVGKVLKHQFRK-AILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGSTSPDLDS--------------------------TDASGGHDDGGTGDSETRRHDEL-GVERGTRQ---PSADKNAARMARK----------------LETSLFYYQRSPNFCERDLGA-DIQGTVGRKC-------------NRN-TT---------TSDG-CTSLC--CGRGHSQVIQRRAE-RCHCK-FQ-----WCCNVECEECHVEEWISICN</mol_seq>\r
2902                           <annotation ref="GO:0005109">\r
2903                             <desc>frizzled binding</desc>\r
2904                           </annotation>\r
2905                           <annotation ref="GO:0005578">\r
2906                             <desc>proteinaceous extracellular matrix</desc>\r
2907                           </annotation>\r
2908                           <annotation ref="GO:0005615">\r
2909                             <desc>extracellular space</desc>\r
2910                           </annotation>\r
2911                           <annotation ref="GO:0016055">\r
2912                             <desc>Wnt signaling pathway</desc>\r
2913                           </annotation>\r
2914                           <annotation ref="GO:0030182">\r
2915                             <desc>neuron differentiation</desc>\r
2916                           </annotation>\r
2917                           <annotation ref="GO:0045165">\r
2918                             <desc>cell fate commitment</desc>\r
2919                           </annotation>\r
2920                           <cross_references>\r
2921                             <accession source="CTD">34011</accession>\r
2922                             <accession source="NextBio">786423</accession>\r
2923                           </cross_references>\r
2924                         </sequence>\r
2925                       </clade>\r
2926                     </clade>\r
2927                   </clade>\r
2928                   <clade>\r
2929                     <name>Q5J2D3_NEMVE/42-349</name>\r
2930                     <branch_length>0.16933</branch_length>\r
2931                     <color>\r
2932                       <red>20</red>\r
2933                       <green>132</green>\r
2934                       <blue>81</blue>\r
2935                     </color>\r
2936                     <taxonomy>\r
2937                       <id provider="uniprot">45351</id>\r
2938                       <code>NEMVE</code>\r
2939                       <scientific_name>Nematostella vectensis</scientific_name>\r
2940                       <common_name>Starlet sea anemone</common_name>\r
2941                       <rank>species</rank>\r
2942                     </taxonomy>\r
2943                     <sequence type="protein">\r
2944                       <accession source="uniprot">Q5J2D3</accession>\r
2945                       <name>Protein Wnt</name>\r
2946                       <mol_seq is_aligned="true">VCKNTPSLS---KEQLKMCRRLPD--------VVASALQGMQYAIHECLAQFRYRRWNCSSLEMKN-------------------------------RNPLANPLLSRG--FRETAFVHAILSAGMTSSVARACSMGKL-AKCGCDESL--------------------RGRGTG-----------------------------------------------------------------------WEWGGCGDNI-DYGIETSAKFLDSRE--------KGRDLHSM--MNMHNNMVGRTTLSENAKTKCKCH---GMCGSCSVKT--------------------CWK-TVPDIREIGDRLMEKYDH-ATTIGMGNGRLRLHLTRR-------------------------------------------------------------------------------------------KARRSS----------------VGRALVYYEDSPNYCIENKEL-GIFGTRGRIC-------------SPE-SL---------DTDN-CQNLC--CERGYTTKKLQVTK-RCRCH-FS-----WWCYLICDTCRETSTVSICS</mol_seq>\r
2947                       <annotation ref="GO:0005578">\r
2948                         <desc>proteinaceous extracellular matrix</desc>\r
2949                       </annotation>\r
2950                       <annotation ref="GO:0007275">\r
2951                         <desc>multicellular organismal development</desc>\r
2952                       </annotation>\r
2953                       <annotation ref="GO:0016055">\r
2954                         <desc>Wnt signaling pathway</desc>\r
2955                       </annotation>\r
2956                     </sequence>\r
2957                   </clade>\r
2958                 </clade>\r
2959                 <clade>\r
2960                   <branch_length>0.02092</branch_length>\r
2961                   <confidence type="bootstrap">12</confidence>\r
2962                   <clade>\r
2963                     <branch_length>0.05896</branch_length>\r
2964                     <confidence type="bootstrap">74</confidence>\r
2965                     <taxonomy>\r
2966                       <id provider="uniprot">1206794</id>\r
2967                       <scientific_name>Ecdysozoa</scientific_name>\r
2968                     </taxonomy>\r
2969                     <clade>\r
2970                       <name>Q9VM26_DROME/49-435</name>\r
2971                       <branch_length>0.37993</branch_length>\r
2972                       <color>\r
2973                         <red>0</red>\r
2974                         <green>173</green>\r
2975                         <blue>193</blue>\r
2976                       </color>\r
2977                       <taxonomy>\r
2978                         <id provider="uniprot">7227</id>\r
2979                         <code>DROME</code>\r
2980                         <scientific_name>Drosophila melanogaster</scientific_name>\r
2981                         <common_name>Fruit fly</common_name>\r
2982                         <rank>species</rank>\r
2983                       </taxonomy>\r
2984                       <sequence type="protein">\r
2985                         <accession source="uniprot">Q9VM26</accession>\r
2986                         <name>Protein Wnt</name>\r
2987                         <gene_name>Wnt6</gene_name>\r
2988                         <mol_seq is_aligned="true">MCKKTRRLR---GKLAEICRHDSA-------LLKEIIINGINLGFRECEFQFRNRRWNCTVLR-----------------------------------KSMRK-ILMRD--SRETGFVNAITAAGVTYAVTKACTMGQL-VECSCDKAHMRRNG---------GQPQMVTAATAEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNNASTMTDIAPVEHRGGRNRRPGGRRGRRKFWDNIKFPEGQWEWGGCSDNV-NFGLRHSRVFLDAKQR------QRRSDLGTL--VKFHNNNAGRLAIRDAMRLECKCH---GLSGSCTVKT--------------------CWL-KMPPFREVAGRLRDRYDS-ARKVTLRNDGNSFMPE----------------------------------------------------------------------------------------------SPHAR----PA----------NKYQLVFADDSPDFCTPNSKT-GALGTQGREC-------------NVT-SS---------GSDR-CDRLC--CNRGHTRRIVEEQT-NCKCV-FK-----WCCEVTCEKCLEHRAVNTCL</mol_seq>\r
2989                         <annotation ref="GO:0005109">\r
2990                           <desc>frizzled binding</desc>\r
2991                         </annotation>\r
2992                         <annotation ref="GO:0005578">\r
2993                           <desc>proteinaceous extracellular matrix</desc>\r
2994                         </annotation>\r
2995                         <annotation ref="GO:0005615">\r
2996                           <desc>extracellular space</desc>\r
2997                         </annotation>\r
2998                         <annotation ref="GO:0016055">\r
2999                           <desc>Wnt signaling pathway</desc>\r
3000                         </annotation>\r
3001                         <annotation ref="GO:0030182">\r
3002                           <desc>neuron differentiation</desc>\r
3003                         </annotation>\r
3004                         <annotation ref="GO:0044719">\r
3005                           <desc>regulation of imaginal disc-derived wing size</desc>\r
3006                         </annotation>\r
3007                         <annotation ref="GO:0045165">\r
3008                           <desc>cell fate commitment</desc>\r
3009                         </annotation>\r
3010                         <cross_references>\r
3011                           <accession source="CTD">7475</accession>\r
3012                           <accession source="NextBio">786418</accession>\r
3013                         </cross_references>\r
3014                       </sequence>\r
3015                     </clade>\r
3016                     <clade>\r
3017                       <name>Q5IWR0_PRIPA/50-417</name>\r
3018                       <branch_length>0.31534</branch_length>\r
3019                       <color>\r
3020                         <red>132</red>\r
3021                         <green>40</green>\r
3022                         <blue>122</blue>\r
3023                       </color>\r
3024                       <taxonomy>\r
3025                         <id provider="uniprot">54126</id>\r
3026                         <code>PRIPA</code>\r
3027                         <scientific_name>Pristionchus pacificus</scientific_name>\r
3028                         <common_name>Parasitic nematode</common_name>\r
3029                         <rank>species</rank>\r
3030                       </taxonomy>\r
3031                       <sequence type="protein">\r
3032                         <accession source="uniprot">Q5IWR0</accession>\r
3033                         <name>Protein Wnt</name>\r
3034                         <gene_name>wnt</gene_name>\r
3035                         <mol_seq is_aligned="true">LCAHLTGLN---PVQQQICTSHPF--------SIPFVSRGLRDAIYECQQQFKMERWNCSDRYEIMKTP-------------------------YGYFHDILGKTLRTT--TKESSYLAAIASAGIVYAVTKGCNTGNF-SDCGCDSKPALQRH---------LEAIELNPPSAAALTSMHPGGPVPYPPPPGM----------------------------------PSSAYPPMGSNGMTGNGPFSWGGCSDNV-GYGVRYARKFLDEFERQ---EFNRTSNVQHL--VAMHNHFVGREAIVQNVRKHCRCH---GVSGSCEFKT--------------------CWL-QMPKMKDVAELLKKRYDNFAVQVTKRAKKRL--------------------------------------------------------------------------------------------------RRKERSERATP---------IRGNEMAFVVRSPTYCERNDTA-GILGTAGRDC-------------VHD-SL---------NADS-CDLLC--CGRGYNTRIERQVT-QCNCK-FV-----WCCQVKCKECVDDVALHTCK</mol_seq>\r
3036                         <annotation ref="GO:0005578">\r
3037                           <desc>proteinaceous extracellular matrix</desc>\r
3038                         </annotation>\r
3039                         <annotation ref="GO:0007275">\r
3040                           <desc>multicellular organismal development</desc>\r
3041                         </annotation>\r
3042                         <annotation ref="GO:0016055">\r
3043                           <desc>Wnt signaling pathway</desc>\r
3044                         </annotation>\r
3045                       </sequence>\r
3046                     </clade>\r
3047                   </clade>\r
3048                   <clade>\r
3049                     <branch_length>0.08769</branch_length>\r
3050                     <confidence type="bootstrap">100</confidence>\r
3051                     <color>\r
3052                       <red>20</red>\r
3053                       <green>71</green>\r
3054                       <blue>142</blue>\r
3055                     </color>\r
3056                     <taxonomy>\r
3057                       <id provider="uniprot">117571</id>\r
3058                       <scientific_name>Euteleostomi</scientific_name>\r
3059                     </taxonomy>\r
3060                     <clade>\r
3061                       <name>WNT6_MOUSE/39-364</name>\r
3062                       <branch_length>0.13199</branch_length>\r
3063                       <color>\r
3064                         <red>20</red>\r
3065                         <green>71</green>\r
3066                         <blue>142</blue>\r
3067                       </color>\r
3068                       <taxonomy>\r
3069                         <id provider="uniprot">10090</id>\r
3070                         <code>MOUSE</code>\r
3071                         <scientific_name>Mus musculus</scientific_name>\r
3072                         <common_name>Mouse</common_name>\r
3073                         <rank>species</rank>\r
3074                       </taxonomy>\r
3075                       <sequence type="protein">\r
3076                         <accession source="uniprot">P22727</accession>\r
3077                         <name>Protein Wnt-6</name>\r
3078                         <gene_name>Wnt6</gene_name>\r
3079                         <mol_seq is_aligned="true">ICRKARRLA---GRQAELCQAEPE--------VVAELARGARLGVRECQFQFRFRRWNCSSHS-----------------------------------KAFGR-VLQQD--IRETAFVFAITAAGASHAVTQACSMGEL-LQCGCQAPRGRAPPRPSGLLGTPGPPGPTGSPDASAA---------------------------------------------------------------------WEWGGCGDDV-DFGDEKSRLFMDAQHK------RGRGDIRAL--VQLHNNEAGRLAVRSHTRTECKCH---GLSGSCALRT--------------------CWQ-KLPPFREVGARLLERFHG-ASRVMGTNDGKALLPA----------------------------------------------------------------------------------------------VRTLK----PP----------GRADLLYAADSPDFCAPNRRT-GSPGTRGRAC-------------NSS-AP---------DLSG-CDLLC--CGRGHRQESVQLEE-NCLCR-FH-----WCCVVQCHRCRVRKELSLCL</mol_seq>\r
3080                         <annotation ref="GO:0001658">\r
3081                           <desc>branching involved in ureteric bud morphogenesis</desc>\r
3082                         </annotation>\r
3083                         <annotation ref="GO:0005102">\r
3084                           <desc>receptor binding</desc>\r
3085                         </annotation>\r
3086                         <annotation ref="GO:0005109">\r
3087                           <desc>frizzled binding</desc>\r
3088                         </annotation>\r
3089                         <annotation ref="GO:0005578">\r
3090                           <desc>proteinaceous extracellular matrix</desc>\r
3091                         </annotation>\r
3092                         <annotation ref="GO:0005615">\r
3093                           <desc>extracellular space</desc>\r
3094                         </annotation>\r
3095                         <annotation ref="GO:0005788">\r
3096                           <desc>endoplasmic reticulum lumen</desc>\r
3097                         </annotation>\r
3098                         <annotation ref="GO:0007165">\r
3099                           <desc>signal transduction</desc>\r
3100                         </annotation>\r
3101                         <annotation ref="GO:0007267">\r
3102                           <desc>cell-cell signaling</desc>\r
3103                         </annotation>\r
3104                         <annotation ref="GO:0009798">\r
3105                           <desc>axis specification</desc>\r
3106                         </annotation>\r
3107                         <annotation ref="GO:0009887">\r
3108                           <desc>organ morphogenesis</desc>\r
3109                         </annotation>\r
3110                         <annotation ref="GO:0009986">\r
3111                           <desc>cell surface</desc>\r
3112                         </annotation>\r
3113                         <annotation ref="GO:0010628">\r
3114                           <desc>positive regulation of gene expression</desc>\r
3115                         </annotation>\r
3116                         <annotation ref="GO:0016055">\r
3117                           <desc>Wnt signaling pathway</desc>\r
3118                         </annotation>\r
3119                         <annotation ref="GO:0030182">\r
3120                           <desc>neuron differentiation</desc>\r
3121                         </annotation>\r
3122                         <annotation ref="GO:0031012">\r
3123                           <desc>extracellular matrix</desc>\r
3124                         </annotation>\r
3125                         <annotation ref="GO:0042475">\r
3126                           <desc>odontogenesis of dentin-containing tooth</desc>\r
3127                         </annotation>\r
3128                         <annotation ref="GO:0045165">\r
3129                           <desc>cell fate commitment</desc>\r
3130                         </annotation>\r
3131                         <annotation ref="GO:0045893">\r
3132                           <desc>positive regulation of transcription, DNA-templated</desc>\r
3133                         </annotation>\r
3134                         <annotation ref="GO:0060684">\r
3135                           <desc>epithelial-mesenchymal cell signaling</desc>\r
3136                         </annotation>\r
3137                         <annotation ref="GO:0070172">\r
3138                           <desc>positive regulation of tooth mineralization</desc>\r
3139                         </annotation>\r
3140                         <annotation ref="GO:0072079">\r
3141                           <desc>nephron tubule formation</desc>\r
3142                         </annotation>\r
3143                         <annotation ref="GO:0072080">\r
3144                           <desc>nephron tubule development</desc>\r
3145                         </annotation>\r
3146                         <cross_references>\r
3147                           <accession source="CTD">7475</accession>\r
3148                           <accession source="KEGG">mmu:22420</accession>\r
3149                           <accession source="NextBio">302849</accession>\r
3150                         </cross_references>\r
3151                       </sequence>\r
3152                     </clade>\r
3153                     <clade>\r
3154                       <name>Q4RNC9_TETNG/40-334</name>\r
3155                       <branch_length>0.07486</branch_length>\r
3156                       <color>\r
3157                         <red>20</red>\r
3158                         <green>71</green>\r
3159                         <blue>142</blue>\r
3160                       </color>\r
3161                       <taxonomy>\r
3162                         <id provider="uniprot">99883</id>\r
3163                         <code>TETNG</code>\r
3164                         <scientific_name>Tetraodon nigroviridis</scientific_name>\r
3165                         <common_name>Spotted green pufferfish</common_name>\r
3166                         <synonym>Chelonodon nigroviridis</synonym>\r
3167                         <rank>species</rank>\r
3168                       </taxonomy>\r
3169                       <sequence type="protein">\r
3170                         <accession source="uniprot">Q4RNC9</accession>\r
3171                         <name>Protein Wnt</name>\r
3172                         <mol_seq is_aligned="true">ICRKAKRLA---GKQAELCQTQPE--------IVREVAKGARLGVRECQYQFRYRRWNCTSHN-----------------------------------KYFGK-ILQQD--IRETAFVYAITAAGVTHAVTQACSMGDR-PQCGFK----------------------------------------------------------------------------------------------------WEWGGCVDDV-EFGYEKSKQFMDAKRR------RGKSDIRAL--IDLHNNEAGRLAVKLYMRTECKCH---GLSGSCTLRT--------------------CWR-KMPHFREVGDRLLERFNG-AFKVMGSNDGKTLIPV----------------------------------------------------------------------------------------------GQNIK----PP----------DKQDLIYSDDSPDFCLANRKT-GSLGTRGRTC-------------NST-AM---------DISG-CDLLC--CERGYQEETVVFEE-NCLCH-FH-----WCCVVQCKKCFVRKELSLCH</mol_seq>\r
3173                         <annotation ref="GO:0005578">\r
3174                           <desc>proteinaceous extracellular matrix</desc>\r
3175                         </annotation>\r
3176                         <annotation ref="GO:0007275">\r
3177                           <desc>multicellular organismal development</desc>\r
3178                         </annotation>\r
3179                         <annotation ref="GO:0016055">\r
3180                           <desc>Wnt signaling pathway</desc>\r
3181                         </annotation>\r
3182                       </sequence>\r
3183                     </clade>\r
3184                   </clade>\r
3185                 </clade>\r
3186               </clade>\r
3187               <clade>\r
3188                 <branch_length>0.01935</branch_length>\r
3189                 <confidence type="bootstrap">33</confidence>\r
3190                 <clade>\r
3191                   <branch_length>0.10758</branch_length>\r
3192                   <confidence type="bootstrap">100</confidence>\r
3193                   <color>\r
3194                     <red>153</red>\r
3195                     <green>112</green>\r
3196                     <blue>0</blue>\r
3197                   </color>\r
3198                   <taxonomy>\r
3199                     <id provider="uniprot">6157</id>\r
3200                     <scientific_name>Platyhelminthes</scientific_name>\r
3201                     <rank>phylum</rank>\r
3202                   </taxonomy>\r
3203                   <clade>\r
3204                     <name>Q589S7_DUGJA/76-402</name>\r
3205                     <branch_length>0.16397</branch_length>\r
3206                     <color>\r
3207                       <red>153</red>\r
3208                       <green>112</green>\r
3209                       <blue>0</blue>\r
3210                     </color>\r
3211                     <taxonomy>\r
3212                       <id provider="uniprot">6161</id>\r
3213                       <code>DUGJA</code>\r
3214                       <scientific_name>Dugesia japonica</scientific_name>\r
3215                       <common_name>Planarian</common_name>\r
3216                       <rank>species</rank>\r
3217                     </taxonomy>\r
3218                     <sequence type="protein">\r
3219                       <accession source="uniprot">Q589S7</accession>\r
3220                       <name>Protein Wnt</name>\r
3221                       <gene_name>Djwnt-A</gene_name>\r
3222                       <mol_seq is_aligned="true">ICQTFSR------HQRKLCNQHFR--------LMESVVNGFLLGLNECQFQFADQIWNCKGHNMTIGGNRSK-------------------SKPRKKGKTYLDKLVSKG--TPEAAYVLSVISAGVAHQVTKACSKGVH-DSCGCDRTI--------------------YDIPETAT---------------------------------------------------------------------FKWSGCSHNI-HFGAAFTRQFLDITEKT----RVNKRPEKAL--TKLHNNHVGRQAVILKMGKKCKCH---GVSGSCEMKT--------------------CIR-ALPDFRVVGDLLKSRFHK-AMQVHFVDSRLIPRYSPNR----------------------------------------------------------------------M-------------------F---------------------TDNDLIYLLKSPNYCVHNPHI-GSLGTQGRKC-----------------AESALLEKKPGETNGTCEELC--CGRGHKKRTFSRME-QCRCK-FQ-----WCCDVKCDLCKKDVIESVCD</mol_seq>\r
3223                       <annotation ref="GO:0005578">\r
3224                         <desc>proteinaceous extracellular matrix</desc>\r
3225                       </annotation>\r
3226                       <annotation ref="GO:0007275">\r
3227                         <desc>multicellular organismal development</desc>\r
3228                       </annotation>\r
3229                       <annotation ref="GO:0016055">\r
3230                         <desc>Wnt signaling pathway</desc>\r
3231                       </annotation>\r
3232                     </sequence>\r
3233                   </clade>\r
3234                   <clade>\r
3235                     <name>A6XBT4_SCHJA/38-436</name>\r
3236                     <branch_length>0.34628</branch_length>\r
3237                     <color>\r
3238                       <red>153</red>\r
3239                       <green>112</green>\r
3240                       <blue>0</blue>\r
3241                     </color>\r
3242                     <taxonomy>\r
3243                       <id provider="uniprot">6182</id>\r
3244                       <code>SCHJA</code>\r
3245                       <scientific_name>Schistosoma japonicum</scientific_name>\r
3246                       <common_name>Blood fluke</common_name>\r
3247                       <rank>species</rank>\r
3248                     </taxonomy>\r
3249                     <sequence type="protein">\r
3250                       <accession source="uniprot">A6XBT4</accession>\r
3251                       <name>Protein Wnt</name>\r
3252                       <mol_seq is_aligned="true">ICDHPNGFL---RRQKKLCRQYLH--------LMESVIRGYFMGLKECEYQFSAHRWNCQGHNLTIQAPTSRKQKRLRYRESELKNDMDNSRRKSVRIQTYLDKLLSKG--TRESAYVLAVTSAGVSHAVTKACSSGLH-DNCGCDRTI--------------------YDHPREPN---------------------------------------------------------------------FEWSGCSDNI-HFGAAFSRQFLDVRERN----RLKRNPKLGL--TNLHNNHVGRHMVINKMEVQCKCH---GVSGSCEMRT--------------------CWR-SLPKFRHLGAQLQERFHE-AIQVTYIQNRLVSMKALEQLSKESNGNALLLS-------------------------------------------HSALLSSVVSGVSSS-DELPA---------SPRINRNAFDTLTRSTSLTTSPLPSPTENDLIYISESPTFCHHDPRY-GSIGTYGRQC-------------DEN-SQ---------GLNS-CNYLC--CGRGFKRQTFVQQE-RCDCK-FQ-----WCCKVVCKTCRKTVVISTCN</mol_seq>\r
3253                       <annotation ref="GO:0005578">\r
3254                         <desc>proteinaceous extracellular matrix</desc>\r
3255                       </annotation>\r
3256                       <annotation ref="GO:0007275">\r
3257                         <desc>multicellular organismal development</desc>\r
3258                       </annotation>\r
3259                       <annotation ref="GO:0016055">\r
3260                         <desc>Wnt signaling pathway</desc>\r
3261                       </annotation>\r
3262                     </sequence>\r
3263                   </clade>\r
3264                 </clade>\r
3265                 <clade>\r
3266                   <branch_length>0.01599</branch_length>\r
3267                   <confidence type="bootstrap">42</confidence>\r
3268                   <clade>\r
3269                     <name>Q4H305_CIOIN/224-608</name>\r
3270                     <branch_length>0.45291</branch_length>\r
3271                     <color>\r
3272                       <red>20</red>\r
3273                       <green>71</green>\r
3274                       <blue>142</blue>\r
3275                     </color>\r
3276                     <taxonomy>\r
3277                       <id provider="uniprot">7719</id>\r
3278                       <code>CIOIN</code>\r
3279                       <scientific_name>Ciona intestinalis</scientific_name>\r
3280                       <common_name>Transparent sea squirt</common_name>\r
3281                       <synonym>Ascidia intestinalis</synonym>\r
3282                       <rank>species</rank>\r
3283                     </taxonomy>\r
3284                     <sequence type="protein">\r
3285                       <accession source="uniprot">Q4H305</accession>\r
3286                       <name>Protein Wnt</name>\r
3287                       <gene_name>Ci-Orphan Wnt e</gene_name>\r
3288                       <mol_seq is_aligned="true">ICLWAQQIG---GPQAEMCANEMP--------VVEEIKKGIQRGAYNCAREFRYSRWNCSQTP-----------------------------------KKFYEKALWQT--TKETSYLQAVTSAAMTFAITEACSLGNI-PECGCVNTRGQKRE---------YLRREAQKRNYYINESYLD-----------------------------------------------------------TFVDQFDWEGCDDNV-DFAYRKTRHFLNFTRFI---GRKRKINLRLR--MSAHNYEAGRLAITEKMAEKCKCH---GFSGTCTIRT--------------------CWM-RMPKFDAVRATLRRMYNT-ATKVNLQPGTRRLVIARRPRRPSSRHRNTAS---------------------------------------------RRTNKVKRGLRKNI-PTRFR---------SRNRKAKNPRRRIRLKNRLRRRLYPVASKHLVYHQPSPNFCRRDKRK-GSLGTKGRVC-------------DPTRRE---------GYGS-CQYMC--CGRGYTTEVVEHTM-KCNCT-FI-----YCCTMTCDECINRYTRYVCR</mol_seq>\r
3289                       <annotation ref="GO:0005578">\r
3290                         <desc>proteinaceous extracellular matrix</desc>\r
3291                       </annotation>\r
3292                       <annotation ref="GO:0007275">\r
3293                         <desc>multicellular organismal development</desc>\r
3294                       </annotation>\r
3295                       <annotation ref="GO:0016055">\r
3296                         <desc>Wnt signaling pathway</desc>\r
3297                       </annotation>\r
3298                       <cross_references>\r
3299                         <accession source="KEGG">cin:778723</accession>\r
3300                       </cross_references>\r
3301                     </sequence>\r
3302                   </clade>\r
3303                   <clade>\r
3304                     <name>A7RSC1_NEMVE/46-365</name>\r
3305                     <branch_length>0.20497</branch_length>\r
3306                     <color>\r
3307                       <red>20</red>\r
3308                       <green>132</green>\r
3309                       <blue>81</blue>\r
3310                     </color>\r
3311                     <taxonomy>\r
3312                       <id provider="uniprot">45351</id>\r
3313                       <code>NEMVE</code>\r
3314                       <scientific_name>Nematostella vectensis</scientific_name>\r
3315                       <common_name>Starlet sea anemone</common_name>\r
3316                       <rank>species</rank>\r
3317                     </taxonomy>\r
3318                     <sequence type="protein">\r
3319                       <accession source="uniprot">A7RSC1</accession>\r
3320                       <name>Protein Wnt</name>\r
3321                       <mol_seq is_aligned="true">FCSLMPWMK---PHQKQKCLLEPL--------VMPSVQRGVGMALEECPNHFSDHKWNCSGVNTA--------------------------------QVFQERGILKTN--TKESAFVFALTSAGVSFQITKGCSLGNW-EQCGCDTQV--------------------RGRVQTKDE------------------------------------------------------------------ASWEWGGCSENV-GHGDDFSRKFMDPEP--------PRKELEYL--LVKHNNEAGRKALKDNMGKTCKCH---GVSGSCTVKI--------------------CWR-TMPNFSVVAQLLRKKFDQ-ATKVKANDKKTKLQRITRG----------------------------------------------------------------------K-------------------RGKKKRQKGRRP----------SAGDLVFAEKSPKFCIPNPEL-GILGTRGRVC-------------DAN-AK---------DNRG-CKKMC--CNRGYDTFKLSNQV-KCNCE-FI-----WCCKVQCDMCKKDWTEYRCR</mol_seq>\r
3322                       <annotation ref="GO:0005578">\r
3323                         <desc>proteinaceous extracellular matrix</desc>\r
3324                       </annotation>\r
3325                       <annotation ref="GO:0007275">\r
3326                         <desc>multicellular organismal development</desc>\r
3327                       </annotation>\r
3328                       <annotation ref="GO:0016055">\r
3329                         <desc>Wnt signaling pathway</desc>\r
3330                       </annotation>\r
3331                     </sequence>\r
3332                   </clade>\r
3333                 </clade>\r
3334               </clade>\r
3335             </clade>\r
3336           </clade>\r
3337           <clade>\r
3338             <branch_length>0.00747</branch_length>\r
3339             <confidence type="bootstrap">19</confidence>\r
3340             <clade>\r
3341               <branch_length>0.01858</branch_length>\r
3342               <confidence type="bootstrap">71</confidence>\r
3343               <clade>\r
3344                 <branch_length>0.0051</branch_length>\r
3345                 <confidence type="bootstrap">53</confidence>\r
3346                 <clade>\r
3347                   <branch_length>0.00652</branch_length>\r
3348                   <confidence type="bootstrap">53</confidence>\r
3349                   <clade>\r
3350                     <branch_length>0.00581</branch_length>\r
3351                     <confidence type="bootstrap">59</confidence>\r
3352                     <clade>\r
3353                       <branch_length>0.02867</branch_length>\r
3354                       <confidence type="bootstrap">100</confidence>\r
3355                       <clade>\r
3356                         <branch_length>0.01102</branch_length>\r
3357                         <confidence type="bootstrap">73</confidence>\r
3358                         <clade>\r
3359                           <branch_length>9.5E-4</branch_length>\r
3360                           <confidence type="bootstrap">32</confidence>\r
3361                           <clade>\r
3362                             <branch_length>0.0061</branch_length>\r
3363                             <confidence type="bootstrap">43</confidence>\r
3364                             <clade>\r
3365                               <branch_length>0.03722</branch_length>\r
3366                               <confidence type="bootstrap">100</confidence>\r
3367                               <color>\r
3368                                 <red>20</red>\r
3369                                 <green>71</green>\r
3370                                 <blue>142</blue>\r
3371                               </color>\r
3372                               <taxonomy>\r
3373                                 <id provider="uniprot">117571</id>\r
3374                                 <scientific_name>Euteleostomi</scientific_name>\r
3375                               </taxonomy>\r
3376                               <clade>\r
3377                                 <name>A1BPR0_DANRE/62-374</name>\r
3378                                 <branch_length>0.06379</branch_length>\r
3379                                 <color>\r
3380                                   <red>20</red>\r
3381                                   <green>71</green>\r
3382                                   <blue>142</blue>\r
3383                                 </color>\r
3384                                 <taxonomy>\r
3385                                   <id provider="uniprot">7955</id>\r
3386                                   <code>DANRE</code>\r
3387                                   <scientific_name>Danio rerio</scientific_name>\r
3388                                   <common_name>Zebrafish</common_name>\r
3389                                   <synonym>Brachydanio rerio</synonym>\r
3390                                   <rank>species</rank>\r
3391                                 </taxonomy>\r
3392                                 <sequence type="protein">\r
3393                                   <accession source="uniprot">A1BPR0</accession>\r
3394                                   <name>Protein Wnt</name>\r
3395                                   <gene_name>wnt5a</gene_name>\r
3396                                   <mol_seq is_aligned="true">LCSQLSGLS---KGQKKLCQLYQD--------HMQYIGEGAKTGIRECQHQFRHRRWNCSTVDNS---------------------------------TVLGR-VMHIG--SRESAFAFAISAAGVLHAVSRACREGAL-SSCGCSRAS--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNL-NYGYRFSREFVDAREREKTFSKGSAESARQM--MNLHNNEAGRRIVSDLADVSCKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGDVLKEKYDS-AAAMRMNGRGKLVQM-----------------------------------------------------------------------------------------------HSKFS----PP----------SGQDLLYLQPSPDYCIRNSSS-GSLGTQGRLC-------------NKT-SE---------GMDG-CALMC--CGRGYDQYKAELVE-RCHCK-FH-----WCCYVRCKRCSSIVDQYVCK</mol_seq>\r
3397                                   <annotation ref="GO:0005578">\r
3398                                     <desc>proteinaceous extracellular matrix</desc>\r
3399                                   </annotation>\r
3400                                   <annotation ref="GO:0007275">\r
3401                                     <desc>multicellular organismal development</desc>\r
3402                                   </annotation>\r
3403                                   <annotation ref="GO:0016055">\r
3404                                     <desc>Wnt signaling pathway</desc>\r
3405                                   </annotation>\r
3406                                   <cross_references>\r
3407                                     <accession source="CTD">7474</accession>\r
3408                                     <accession source="KEGG">dre:568191</accession>\r
3409                                     <accession source="NextBio">20889048</accession>\r
3410                                   </cross_references>\r
3411                                 </sequence>\r
3412                               </clade>\r
3413                               <clade>\r
3414                                 <name>Q6DII0_XENTR/48-360</name>\r
3415                                 <branch_length>0.05868</branch_length>\r
3416                                 <color>\r
3417                                   <red>20</red>\r
3418                                   <green>71</green>\r
3419                                   <blue>142</blue>\r
3420                                 </color>\r
3421                                 <taxonomy>\r
3422                                   <id provider="uniprot">8364</id>\r
3423                                   <code>XENTR</code>\r
3424                                   <scientific_name>Xenopus tropicalis</scientific_name>\r
3425                                   <common_name>Western clawed frog</common_name>\r
3426                                   <synonym>Silurana tropicalis</synonym>\r
3427                                   <rank>species</rank>\r
3428                                 </taxonomy>\r
3429                                 <sequence type="protein">\r
3430                                   <accession source="uniprot">Q6DII0</accession>\r
3431                                   <name>Protein Wnt</name>\r
3432                                   <gene_name>wnt5b</gene_name>\r
3433                                   <mol_seq is_aligned="true">LCSQLTGLS---PGQRKLCQLYQD--------HMVYIGEGAKTGIKECQHQFKHRRWNCSTVDNN---------------------------------SVFGR-VMQIG--SREAAFTYAISAAGVVNAISRACREGEL-STCGCSRTP--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNV-EYGYRFAKEFVDAREREKNFPKGSEEQARSL--MNLQNNEAGRRAVYKLADVACKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGEYIKEKYDS-AASMRLNKRNKLEQV-----------------------------------------------------------------------------------------------NQRFN----PP----------TAEDLVYLDPSPDYCLYNETT-GSLGTHGRQC-------------NKT-SE---------GMDG-CELMC--CGRGYDQFKTVQVE-RCHCK-FH-----WCCFVKCKKCTEIVDQYVCK</mol_seq>\r
3434                                   <annotation ref="GO:0001525">\r
3435                                     <desc>angiogenesis</desc>\r
3436                                   </annotation>\r
3437                                   <annotation ref="GO:0002062">\r
3438                                     <desc>chondrocyte differentiation</desc>\r
3439                                   </annotation>\r
3440                                   <annotation ref="GO:0002574">\r
3441                                     <desc>thrombocyte differentiation</desc>\r
3442                                   </annotation>\r
3443                                   <annotation ref="GO:0005578">\r
3444                                     <desc>proteinaceous extracellular matrix</desc>\r
3445                                   </annotation>\r
3446                                   <annotation ref="GO:0005622">\r
3447                                     <desc>intracellular</desc>\r
3448                                   </annotation>\r
3449                                   <annotation ref="GO:0007223">\r
3450                                     <desc>Wnt signaling pathway, calcium modulating pathway</desc>\r
3451                                   </annotation>\r
3452                                   <annotation ref="GO:0008591">\r
3453                                     <desc>regulation of Wnt signaling pathway, calcium modulating pathway</desc>\r
3454                                   </annotation>\r
3455                                   <annotation ref="GO:0009826">\r
3456                                     <desc>unidimensional cell growth</desc>\r
3457                                   </annotation>\r
3458                                   <annotation ref="GO:0010172">\r
3459                                     <desc>embryonic body morphogenesis</desc>\r
3460                                   </annotation>\r
3461                                   <annotation ref="GO:0031018">\r
3462                                     <desc>endocrine pancreas development</desc>\r
3463                                   </annotation>\r
3464                                   <annotation ref="GO:0031101">\r
3465                                     <desc>fin regeneration</desc>\r
3466                                   </annotation>\r
3467                                   <annotation ref="GO:0048840">\r
3468                                     <desc>otolith development</desc>\r
3469                                   </annotation>\r
3470                                   <annotation ref="GO:0048884">\r
3471                                     <desc>neuromast development</desc>\r
3472                                   </annotation>\r
3473                                   <annotation ref="GO:0051209">\r
3474                                     <desc>release of sequestered calcium ion into cytosol</desc>\r
3475                                   </annotation>\r
3476                                   <annotation ref="GO:0060028">\r
3477                                     <desc>convergent extension involved in axis elongation</desc>\r
3478                                   </annotation>\r
3479                                   <annotation ref="GO:0060030">\r
3480                                     <desc>dorsal convergence</desc>\r
3481                                   </annotation>\r
3482                                   <annotation ref="GO:0061053">\r
3483                                     <desc>somite development</desc>\r
3484                                   </annotation>\r
3485                                   <cross_references>\r
3486                                     <accession source="CTD">81029</accession>\r
3487                                     <accession source="KEGG">xtr:448452</accession>\r
3488                                   </cross_references>\r
3489                                 </sequence>\r
3490                               </clade>\r
3491                             </clade>\r
3492                             <clade>\r
3493                               <name>O96867_STRPU/19-331</name>\r
3494                               <branch_length>0.09595</branch_length>\r
3495                               <color>\r
3496                                 <red>40</red>\r
3497                                 <green>20</green>\r
3498                                 <blue>71</blue>\r
3499                               </color>\r
3500                               <taxonomy>\r
3501                                 <id provider="uniprot">7668</id>\r
3502                                 <code>STRPU</code>\r
3503                                 <scientific_name>Strongylocentrotus purpuratus</scientific_name>\r
3504                                 <common_name>Purple sea urchin</common_name>\r
3505                                 <rank>species</rank>\r
3506                               </taxonomy>\r
3507                               <sequence type="protein">\r
3508                                 <accession source="uniprot">O96867</accession>\r
3509                                 <name>Protein Wnt</name>\r
3510                                 <gene_name>spwnt-5</gene_name>\r
3511                                 <mol_seq is_aligned="true">LCSELLGLS---PGQQKLCQLYQD--------HMAPIGEGAKMSIDECQNQFTNRRWNCSTVDSN---------------------------------NVFGK-VLSIS--SREAAFTYAITSAGVVNAISRSCREGQL-STCGCGKSP--------------------RPPDIPRD---------------------------------------------------------------------WVWGGCGDNI-DYGFRFAREFVDAREMETNPQRGSFAYDRMK--MNLHNNEAGRKAVYDNAGTECKCH---GVSGSCSLKT--------------------CWL-QLSPFNRVGTILKDKYDG-ATNVRVNKKGRLVNS-----------------------------------------------------------------------------------------------DARFN----KP----------TRDDLVYLQPSPDYCLPDIQT-GSLGTTGREC-------------NKT-SM---------GTDG-CTLMC--CGRGYNSFTKEVVE-RCKCK-FK-----WCCYVKCRKCRTLVDVHVCK</mol_seq>\r
3512                                 <annotation ref="GO:0005578">\r
3513                                   <desc>proteinaceous extracellular matrix</desc>\r
3514                                 </annotation>\r
3515                                 <annotation ref="GO:0007275">\r
3516                                   <desc>multicellular organismal development</desc>\r
3517                                 </annotation>\r
3518                                 <annotation ref="GO:0016055">\r
3519                                   <desc>Wnt signaling pathway</desc>\r
3520                                 </annotation>\r
3521                               </sequence>\r
3522                             </clade>\r
3523                           </clade>\r
3524                           <clade>\r
3525                             <name>Q8WS75_BRAFL/55-370</name>\r
3526                             <branch_length>0.10636</branch_length>\r
3527                             <color>\r
3528                               <red>20</red>\r
3529                               <green>71</green>\r
3530                               <blue>142</blue>\r
3531                             </color>\r
3532                             <taxonomy>\r
3533                               <id provider="uniprot">7739</id>\r
3534                               <code>BRAFL</code>\r
3535                               <scientific_name>Branchiostoma floridae</scientific_name>\r
3536                               <common_name>Florida lancelet</common_name>\r
3537                               <synonym>Amphioxus</synonym>\r
3538                               <rank>species</rank>\r
3539                             </taxonomy>\r
3540                             <sequence type="protein">\r
3541                               <accession source="uniprot">Q8WS75</accession>\r
3542                               <name>Protein Wnt</name>\r
3543                               <gene_name>Wnt5</gene_name>\r
3544                               <mol_seq is_aligned="true">LCTTLAGLS---SGQRKLCNLYQD--------HMSSVGIGARQGIEECQHQFRDRRWNCTTSDED---------------------------------SVFGR-IVNIG--SREASFTYAIAAAGVVNAVSRACREGEL-TTCGCSRAK--------------------RPKDLNRD---------------------------------------------------------------------WLWGGCGDDV-EYGYYFAREFVDAQEKQIIPTPGSQAHARQL--MNMHNNEAGRKLTFSNARVACKCH---GVSGSCSLKT--------------------CWQ-QLADFRTVGNLLKDKYDG-ANEVKLIKRGKRYRLDRR--------------------------------------------------------------------------------------------NPRFN----VF----------TDEDLVYLNKSPDYCNADPTI-GSLGTHGREC-------------NKT-GL---------GTDG-CNLMC--CGRGYNTFKREKVE-RCNCK-FH-----WCCYVKCKRCRSIKNVYVCK</mol_seq>\r
3545                               <annotation ref="GO:0005578">\r
3546                                 <desc>proteinaceous extracellular matrix</desc>\r
3547                               </annotation>\r
3548                               <annotation ref="GO:0007275">\r
3549                                 <desc>multicellular organismal development</desc>\r
3550                               </annotation>\r
3551                               <annotation ref="GO:0016055">\r
3552                                 <desc>Wnt signaling pathway</desc>\r
3553                               </annotation>\r
3554                             </sequence>\r
3555                           </clade>\r
3556                         </clade>\r
3557                         <clade>\r
3558                           <name>Q75PH7_PARTP/66-378</name>\r
3559                           <branch_length>0.11208</branch_length>\r
3560                           <color>\r
3561                             <red>0</red>\r
3562                             <green>173</green>\r
3563                             <blue>193</blue>\r
3564                           </color>\r
3565                           <taxonomy>\r
3566                             <id provider="uniprot">114398</id>\r
3567                             <code>PARTP</code>\r
3568                             <scientific_name>Parasteatoda tepidariorum</scientific_name>\r
3569                             <common_name>House spider</common_name>\r
3570                             <synonym>Achaearanea tepidariorum</synonym>\r
3571                             <rank>species</rank>\r
3572                           </taxonomy>\r
3573                           <sequence type="protein">\r
3574                             <accession source="uniprot">Q75PH7</accession>\r
3575                             <name>Protein Wnt</name>\r
3576                             <gene_name>wnt5</gene_name>\r
3577                             <mol_seq is_aligned="true">LCSRLSGLS---RGQTKLCYLYQD--------HMAHVARGARLGIHECQWQFKNRRWNCSTVDDS---------------------------------SVFGP-VLNIG--SREAGFAHAVAAAGVVHTVSRGCRDGQL-SNCGCSRAM--------------------RPKNLHRD---------------------------------------------------------------------WIWGGCGDNI-EYGYRFTEGFVDVKEREINHARGSREQGRKL--MNLHNNEAGRRAVIRKVRVTCKCH---GVSGSCSLVT--------------------CWQ-QLAPFREVGDYLKDKYDG-ATEVKINHRGKLQIR-----------------------------------------------------------------------------------------------NPRYN----LP----------TAEDLVYVDESPDYCVPNEET-GSWGTEGRVC-------------NRT-SP---------STDG-CNLMC--CGRGYNTHKTTIKE-RCKCK-FH-----WCCYVECKTCHYVLDIQSCK</mol_seq>\r
3578                             <annotation ref="GO:0005578">\r
3579                               <desc>proteinaceous extracellular matrix</desc>\r
3580                             </annotation>\r
3581                             <annotation ref="GO:0007275">\r
3582                               <desc>multicellular organismal development</desc>\r
3583                             </annotation>\r
3584                             <annotation ref="GO:0016055">\r
3585                               <desc>Wnt signaling pathway</desc>\r
3586                             </annotation>\r
3587                           </sequence>\r
3588                         </clade>\r
3589                       </clade>\r
3590                       <clade>\r
3591                         <name>A2SXV2_9MOLL/64-376</name>\r
3592                         <branch_length>0.12755</branch_length>\r
3593                         <color>\r
3594                           <red>255</red>\r
3595                           <green>122</green>\r
3596                           <blue>142</blue>\r
3597                         </color>\r
3598                         <taxonomy>\r
3599                           <id provider="uniprot">6613</id>\r
3600                           <code>9MOLL</code>\r
3601                           <scientific_name>Euprymna scolopes</scientific_name>\r
3602                           <rank>phylum</rank>\r
3603                         </taxonomy>\r
3604                         <sequence type="protein">\r
3605                           <accession source="uniprot">A2SXV2</accession>\r
3606                           <name>Protein Wnt</name>\r
3607                           <gene_name>Wnt5</gene_name>\r
3608                           <mol_seq is_aligned="true">MCVALKGLS---PGQIRICQLFYD--------HMPSVGRGAQLGIRECQYQFRNRRWNCSTVNDE---------------------------------SVFGP-VMELG--SRETGFTHAVSSAGVVYSVSRACPEXQL-SRCGCSKAP--------------------RPPIHKD----------------------------------------------------------------------WLWGDCGDNI-EHGYRFALGFIDKREKERNYPRFSRGLARML--MNLHNNEAGRRAIYKHATVSCKCH---GVSGSCSLKT--------------------CWQ-SSPDFRSVGNRLKEKYNG-ATKVRFNSRGTRLIRR----------------------------------------------------------------------------------------------DHKFN----KP----------TKEDIIYLDDSPDYCMAKPEA-GVLGTVGREC-------------NWT-SK---------GLGG-CALMC--CGRGYNSFRKKVQE-RCHCK-FE-----WCCEVKCDLCEYFVDVHVCK</mol_seq>\r
3609                           <annotation ref="GO:0005578">\r
3610                             <desc>proteinaceous extracellular matrix</desc>\r
3611                           </annotation>\r
3612                           <annotation ref="GO:0007275">\r
3613                             <desc>multicellular organismal development</desc>\r
3614                           </annotation>\r
3615                           <annotation ref="GO:0016055">\r
3616                             <desc>Wnt signaling pathway</desc>\r
3617                           </annotation>\r
3618                         </sequence>\r
3619                       </clade>\r
3620                     </clade>\r
3621                     <clade>\r
3622                       <branch_length>0.0412</branch_length>\r
3623                       <confidence type="bootstrap">100</confidence>\r
3624                       <color>\r
3625                         <red>20</red>\r
3626                         <green>71</green>\r
3627                         <blue>142</blue>\r
3628                       </color>\r
3629                       <taxonomy>\r
3630                         <id provider="uniprot">7713</id>\r
3631                         <scientific_name>Ascidiacea</scientific_name>\r
3632                         <rank>class</rank>\r
3633                       </taxonomy>\r
3634                       <clade>\r
3635                         <branch_length>0.01291</branch_length>\r
3636                         <confidence type="bootstrap">87</confidence>\r
3637                         <color>\r
3638                           <red>20</red>\r
3639                           <green>71</green>\r
3640                           <blue>142</blue>\r
3641                         </color>\r
3642                         <clade>\r
3643                           <name>Q9U6V0_CIOIN/49-360</name>\r
3644                           <branch_length>0.10739</branch_length>\r
3645                           <color>\r
3646                             <red>20</red>\r
3647                             <green>71</green>\r
3648                             <blue>142</blue>\r
3649                           </color>\r
3650                           <taxonomy>\r
3651                             <id provider="uniprot">7719</id>\r
3652                             <code>CIOIN</code>\r
3653                             <scientific_name>Ciona intestinalis</scientific_name>\r
3654                             <common_name>Transparent sea squirt</common_name>\r
3655                             <synonym>Ascidia intestinalis</synonym>\r
3656                             <rank>species</rank>\r
3657                           </taxonomy>\r
3658                           <sequence type="protein">\r
3659                             <accession source="uniprot">Q9U6V0</accession>\r
3660                             <name>Protein Wnt</name>\r
3661                             <gene_name>wnt5</gene_name>\r
3662                             <mol_seq is_aligned="true">ICGQLEGLS---RNQRALCQRYAN--------HMAHVSEGAGIGINECKWQFRGQRWNCSTVDDS---------------------------------SVFGK-VLKIG--SKETAFTYAISAAGVVVAVARACKNEQL-ENCGCGNKA--------------------RPEGLDAS---------------------------------------------------------------------WRWGGCGDNT-EYAYGFAREFIDARERDNISPKRRKDRERKV--MNMHNNEAGRMVVVRSARPTCKCH---GVSGSCSLKT--------------------CWM-QVPGFREIGDELMRKYIG-GVEVRVTNRGQLRPRR----------------------------------------------------------------------------------------------SNDEV----------------GSTSLVYLDSSPDYCDKNRRT-GVAGTKGREC-------------KKD-SS---------GPEG-CGLLC--CGRGFRTYRVRVVE-KCECK-FQ-----WCCSVKCNLCQRTVKRHICR</mol_seq>\r
3663                             <annotation ref="GO:0005109">\r
3664                               <desc>frizzled binding</desc>\r
3665                             </annotation>\r
3666                             <annotation ref="GO:0005578">\r
3667                               <desc>proteinaceous extracellular matrix</desc>\r
3668                             </annotation>\r
3669                             <annotation ref="GO:0005615">\r
3670                               <desc>extracellular space</desc>\r
3671                             </annotation>\r
3672                             <annotation ref="GO:0016055">\r
3673                               <desc>Wnt signaling pathway</desc>\r
3674                             </annotation>\r
3675                             <annotation ref="GO:0030182">\r
3676                               <desc>neuron differentiation</desc>\r
3677                             </annotation>\r
3678                             <annotation ref="GO:0045165">\r
3679                               <desc>cell fate commitment</desc>\r
3680                             </annotation>\r
3681                             <cross_references>\r
3682                               <accession source="CTD">32838</accession>\r
3683                               <accession source="KEGG">cin:445761</accession>\r
3684                             </cross_references>\r
3685                           </sequence>\r
3686                         </clade>\r
3687                         <clade>\r
3688                           <name>Q8T8A8_HALRO/49-371</name>\r
3689                           <branch_length>0.13419</branch_length>\r
3690                           <color>\r
3691                             <red>20</red>\r
3692                             <green>71</green>\r
3693                             <blue>142</blue>\r
3694                           </color>\r
3695                           <taxonomy>\r
3696                             <id provider="uniprot">7729</id>\r
3697                             <code>HALRO</code>\r
3698                             <scientific_name>Halocynthia roretzi</scientific_name>\r
3699                             <common_name>Sea squirt</common_name>\r
3700                             <synonym>Cynthia roretzi</synonym>\r
3701                             <rank>species</rank>\r
3702                           </taxonomy>\r
3703                           <sequence type="protein">\r
3704                             <accession source="uniprot">Q8T8A8</accession>\r
3705                             <name>Protein Wnt</name>\r
3706                             <gene_name>HrWnt-5beta</gene_name>\r
3707                             <mol_seq is_aligned="true">PCSEIPSLS---HSQRALCQKYRD--------HILLVSEGAQKGIEECQYQFRARRWNCSTTTNKKRKID-----------------------NNDSSTVFGK-VIDIG--SRETAFTYAISAAGVVHAIARGCKEGRL-EACGCSNSP--------------------RPDGLRDE---------------------------------------------------------------------WEWGGCGDNL-DYAYGFAHEFIDARERDNVSPRNLKSRSRKV--MNLHNNEAGRMTVVRGARPTCKCN---GVSGSCSLNT--------------------CWL-RVPHFREIGDKIREKHDS-SIEIKVNKRSRMRPR-----------------------------------------------------------------------------------------------KKSIE----SP----------TITDLVHLDSSPDYCRANSRT-GVLGTKGREC-------------NAH-SD---------GSDG-CGLMC--CGRGYDTRVVDVEE-RCNCR-FQ-----WCCVVRCQKCIKRVQRYICR</mol_seq>\r
3708                             <annotation ref="GO:0005578">\r
3709                               <desc>proteinaceous extracellular matrix</desc>\r
3710                             </annotation>\r
3711                             <annotation ref="GO:0007275">\r
3712                               <desc>multicellular organismal development</desc>\r
3713                             </annotation>\r
3714                             <annotation ref="GO:0016055">\r
3715                               <desc>Wnt signaling pathway</desc>\r
3716                             </annotation>\r
3717                           </sequence>\r
3718                         </clade>\r
3719                       </clade>\r
3720                       <clade>\r
3721                         <name>WNT5_HALRO/52-363</name>\r
3722                         <branch_length>0.135</branch_length>\r
3723                         <color>\r
3724                           <red>20</red>\r
3725                           <green>71</green>\r
3726                           <blue>142</blue>\r
3727                         </color>\r
3728                         <taxonomy>\r
3729                           <id provider="uniprot">7729</id>\r
3730                           <code>HALRO</code>\r
3731                           <scientific_name>Halocynthia roretzi</scientific_name>\r
3732                           <common_name>Sea squirt</common_name>\r
3733                           <synonym>Cynthia roretzi</synonym>\r
3734                           <rank>species</rank>\r
3735                         </taxonomy>\r
3736                         <sequence type="protein">\r
3737                           <accession source="uniprot">O15978</accession>\r
3738                           <name>Protein Wnt-5</name>\r
3739                           <gene_name>WNT5</gene_name>\r
3740                           <mol_seq is_aligned="true">HCDEIRGLS---RNQRSLCRTYND--------HMYYVESGSKQGVEECQWQFRGQRWNCSLASN----------------------------------ASPDK-IIAVG--SKETAFTYAITSGGVVQSIARACKSGNL-MACGCSKRE--------------------RPTGLGKD---------------------------------------------------------------------WNWGGCGDDI-DYAYGFAHEFIDAQERDNSSPNDRRVKSHKA--MNIHNNEAGRLSVVRASHTTCKCH---GVSGSCSIKT--------------------CWL-QTPQFRTIGDKLRQRYDD-ALEMRVTHRGQMKTR-----------------------------------------------------------------------------------------------FSSDR----NP----------SNIDLVYIDSSPDYCKVNHKL-GILGTSGREC-------------QLD-SL---------AMDG-CGLMC--CGRGYTTKMVEVVK-SCNCK-FQ-----WCCFVKCQQCKEKVLKHICN</mol_seq>\r
3741                           <annotation ref="GO:0005578">\r
3742                             <desc>proteinaceous extracellular matrix</desc>\r
3743                           </annotation>\r
3744                           <annotation ref="GO:0007275">\r
3745                             <desc>multicellular organismal development</desc>\r
3746                           </annotation>\r
3747                           <annotation ref="GO:0016055">\r
3748                             <desc>Wnt signaling pathway</desc>\r
3749                           </annotation>\r
3750                         </sequence>\r
3751                       </clade>\r
3752                     </clade>\r
3753                   </clade>\r
3754                   <clade>\r
3755                     <name>A8WV10_CAEBR/44-360</name>\r
3756                     <branch_length>0.18334</branch_length>\r
3757                     <color>\r
3758                       <red>132</red>\r
3759                       <green>40</green>\r
3760                       <blue>122</blue>\r
3761                     </color>\r
3762                     <taxonomy>\r
3763                       <id provider="uniprot">6238</id>\r
3764                       <code>CAEBR</code>\r
3765                       <scientific_name>Caenorhabditis briggsae</scientific_name>\r
3766                       <rank>species</rank>\r
3767                     </taxonomy>\r
3768                     <sequence type="protein">\r
3769                       <accession source="uniprot">A8WV10</accession>\r
3770                       <name>Protein CBR-CWN-2</name>\r
3771                       <gene_name>cwn-2</gene_name>\r
3772                       <mol_seq is_aligned="true">PVCELPGLS---PGQAQVCELFKD--------HMPAVSIGAQNAIQECQRQFTGHRWNCSTHYST---------------------------------GMLGP-IHKMA--TREAAFTYAILSAGVTHEIGRRCKQGLL-TSCGCSDET--------------------KPKNVPTD---------------------------------------------------------------------WSWGGCGDNV-EYGYKFSRDFIDIREKEH-DPKRNHDNGRSL--MNRRNNEAGRKILKRHRKPKCKCH---GVSGACNMKT--------------------CWM-QLPSMEQVGKILRNKYDK-AIRVQINDRGNLQLLA----------------------------------------------------------------------------------------------DETSKERKTRA----------LPTDLVFMDDSPDYCRFDRHS-GTLGTEGRVC-------------KRG-SS---------GAEG-CDSLC--CGRGYNTYTQEVKS-KCNCK-FE-----WCCKVVCQTCNNMTQVDICK</mol_seq>\r
3773                       <annotation ref="GO:0005578">\r
3774                         <desc>proteinaceous extracellular matrix</desc>\r
3775                       </annotation>\r
3776                       <annotation ref="GO:0007275">\r
3777                         <desc>multicellular organismal development</desc>\r
3778                       </annotation>\r
3779                       <annotation ref="GO:0016055">\r
3780                         <desc>Wnt signaling pathway</desc>\r
3781                       </annotation>\r
3782                       <cross_references>\r
3783                         <accession source="CTD">8575733</accession>\r
3784                       </cross_references>\r
3785                     </sequence>\r
3786                   </clade>\r
3787                 </clade>\r
3788                 <clade>\r
3789                   <name>Q5IHW1_NEMVE/31-358</name>\r
3790                   <branch_length>0.21141</branch_length>\r
3791                   <color>\r
3792                     <red>20</red>\r
3793                     <green>132</green>\r
3794                     <blue>81</blue>\r
3795                   </color>\r
3796                   <taxonomy>\r
3797                     <id provider="uniprot">45351</id>\r
3798                     <code>NEMVE</code>\r
3799                     <scientific_name>Nematostella vectensis</scientific_name>\r
3800                     <common_name>Starlet sea anemone</common_name>\r
3801                     <rank>species</rank>\r
3802                   </taxonomy>\r
3803                   <sequence type="protein">\r
3804                     <accession source="uniprot">Q5IHW1</accession>\r
3805                     <name>Protein Wnt</name>\r
3806                     <gene_name>Wnt5</gene_name>\r
3807                     <mol_seq is_aligned="true">LCMNLGGLT---REQIDLCQKNID--------HMASVGLGAKMAIQECQFQYQYEKWNCSIPDAEK-------------------------------SSLFER-ITSKDVATREAALTYAISSAGVVWALARACTEGNL-STCSCSRER--------------------RPLDLNKE---------------------------------------------------------------------YQWGGCGDNI-EYAVKFGREFMEAGEDHRPTEEDRKKYARTL--MNLHNNNLGRRVVKDISVVECKCH---GVCGSCNLKT--------------------CWR-QLVEFREIGNALHDKYDA-AVQVALKRKEGRSLLLPMR---------------------------------------------------------------------SR-------------------HYSQRKAKSAQE----------TRDELVYIDKSPDFCSKNAAH-GAQGTRGRKC-------------IKE-SL---------GKDG-CNLLC--CSRGYKMKKEVQAT-RCRCK-FH-----WCCKVKCKTCIKNVTTHICN</mol_seq>\r
3808                     <annotation ref="GO:0005578">\r
3809                       <desc>proteinaceous extracellular matrix</desc>\r
3810                     </annotation>\r
3811                     <annotation ref="GO:0007275">\r
3812                       <desc>multicellular organismal development</desc>\r
3813                     </annotation>\r
3814                     <annotation ref="GO:0016055">\r
3815                       <desc>Wnt signaling pathway</desc>\r
3816                     </annotation>\r
3817                   </sequence>\r
3818                 </clade>\r
3819               </clade>\r
3820               <clade>\r
3821                 <name>A5AA55_HYDVU/16-337</name>\r
3822                 <branch_length>0.23324</branch_length>\r
3823                 <color>\r
3824                   <red>20</red>\r
3825                   <green>132</green>\r
3826                   <blue>81</blue>\r
3827                 </color>\r
3828                 <taxonomy>\r
3829                   <id provider="uniprot">6087</id>\r
3830                   <code>HYDVU</code>\r
3831                   <scientific_name>Hydra vulgaris</scientific_name>\r
3832                   <common_name>Hydra</common_name>\r
3833                   <synonym>Hydra attenuata</synonym>\r
3834                   <rank>species</rank>\r
3835                 </taxonomy>\r
3836                 <sequence type="protein">\r
3837                   <accession source="uniprot">A5AA55</accession>\r
3838                   <name>Protein Wnt</name>\r
3839                   <gene_name>wnt5</gene_name>\r
3840                   <mol_seq is_aligned="true">ICDKRRSLT---EKQIKLCNTNSD--------HMAYIIEGRRIAIEECMKQFSDRGWNCTFPEPN--------------------------------IIPFLHPYMPLG--TRETAFVHSIIAAATMHSISRACMENKLSSHCSCSQEK--------------------KPENLPKT---------------------------------------------------------------------DMWNGCGDNL-PYGYQFSKEFVDSKETIL--KDSAFNFGRVL--MNLHNNEAGRWAVFEKSKIQCRCH---GVSKNCATKT--------------------CYR-QLSEFKDVGYQLEQLHQS-AIHVQLSQSGQKNDTEIT-------------------------------------------------------------------------------------------KLVQFNSNIDIY----------TSKDMIYLDDSPSYCNQNLSI-GSFGTEGREC-------------IKD-DN---------SSKE-CGRLC--CEKGHYTKKVFTTE-NCACK-FI-----WCCEVKCQSCKKQQNKHYCK</mol_seq>\r
3841                   <annotation ref="GO:0005578">\r
3842                     <desc>proteinaceous extracellular matrix</desc>\r
3843                   </annotation>\r
3844                   <annotation ref="GO:0007275">\r
3845                     <desc>multicellular organismal development</desc>\r
3846                   </annotation>\r
3847                   <annotation ref="GO:0016055">\r
3848                     <desc>Wnt signaling pathway</desc>\r
3849                   </annotation>\r
3850                 </sequence>\r
3851               </clade>\r
3852             </clade>\r
3853             <clade>\r
3854               <branch_length>0.00466</branch_length>\r
3855               <confidence type="bootstrap">21</confidence>\r
3856               <clade>\r
3857                 <branch_length>0.03316</branch_length>\r
3858                 <confidence type="bootstrap">100</confidence>\r
3859                 <clade>\r
3860                   <branch_length>0.01423</branch_length>\r
3861                   <confidence type="bootstrap">92</confidence>\r
3862                   <clade>\r
3863                     <branch_length>0.00736</branch_length>\r
3864                     <confidence type="bootstrap">20</confidence>\r
3865                     <clade>\r
3866                       <branch_length>0.00804</branch_length>\r
3867                       <confidence type="bootstrap">24</confidence>\r
3868                       <clade>\r
3869                         <name>Q9TZT6_BRAFL/41-353</name>\r
3870                         <branch_length>0.09109</branch_length>\r
3871                         <color>\r
3872                           <red>20</red>\r
3873                           <green>71</green>\r
3874                           <blue>142</blue>\r
3875                         </color>\r
3876                         <taxonomy>\r
3877                           <id provider="uniprot">7739</id>\r
3878                           <code>BRAFL</code>\r
3879                           <scientific_name>Branchiostoma floridae</scientific_name>\r
3880                           <common_name>Florida lancelet</common_name>\r
3881                           <synonym>Amphioxus</synonym>\r
3882                           <rank>species</rank>\r
3883                         </taxonomy>\r
3884                         <sequence type="protein">\r
3885                           <accession source="uniprot">Q9TZT6</accession>\r
3886                           <name>Protein Wnt</name>\r
3887                           <gene_name>Wnt4</gene_name>\r
3888                           <mol_seq is_aligned="true">ACEKLHGLI---SRQVQICKRNVE--------VMDSVKEGARMSIEECQFQFRHRRWNCSTLINRR-------------------------------GPVFGK-VLEEG--TREAAFVHSISAAGVAHAVTRACSSGEL-ERCGCNRTV--------------------RGTIPEG----------------------------------------------------------------------FHWAGCSDNF-AFGAAFSQTFVDARERG----RVAATSSRAL--MNLHNNEAGRRNLVDHMKTECKCH---GVSGSCELKT--------------------CWR-AMPPFREVGARLKEKFDG-ATEVQQKKIGSRRELVPL--------------------------------------------------------------------------------------------NSDFK----PH----------SSSDLVYLDASPDFCVRDTKV-GSMGTVGRVC-------------NKT-SK---------AIDG-CELLC--CGRGYNTHTREVVE-RCSCK-FH-----WCCYVKCKTCRRTVEVHTCK</mol_seq>\r
3889                           <annotation ref="GO:0005578">\r
3890                             <desc>proteinaceous extracellular matrix</desc>\r
3891                           </annotation>\r
3892                           <annotation ref="GO:0007275">\r
3893                             <desc>multicellular organismal development</desc>\r
3894                           </annotation>\r
3895                           <annotation ref="GO:0016055">\r
3896                             <desc>Wnt signaling pathway</desc>\r
3897                           </annotation>\r
3898                         </sequence>\r
3899                       </clade>\r
3900                       <clade>\r
3901                         <name>Q8MPL6_PLADU/43-355</name>\r
3902                         <branch_length>0.09896</branch_length>\r
3903                         <color>\r
3904                           <red>0</red>\r
3905                           <green>132</green>\r
3906                           <blue>132</blue>\r
3907                         </color>\r
3908                         <taxonomy>\r
3909                           <id provider="uniprot">6359</id>\r
3910                           <code>PLADU</code>\r
3911                           <scientific_name>Platynereis dumerilii</scientific_name>\r
3912                           <common_name>Dumeril&apos;s clam worm</common_name>\r
3913                           <rank>species</rank>\r
3914                         </taxonomy>\r
3915                         <sequence type="protein">\r
3916                           <accession source="uniprot">Q8MPL6</accession>\r
3917                           <name>Protein Wnt</name>\r
3918                           <gene_name>wnt4</gene_name>\r
3919                           <mol_seq is_aligned="true">ECNVLDGLV---KKQKKICKKHVE--------MMGAVRKGAIEAIHECQFQFRNRRWNCSTVDAS---------------------------------TIFGN-VLHQG--SREASFVHAISSAGVAHPVTRACSSGTM-SECGCDRTV--------------------RGRSPAG----------------------------------------------------------------------FEWAGCSDNI-AFGTAFSRTFVDARERVR--KDREGSSSRVL--MNLHNNEAGRKIIEENMLTQCKCH---GVSGSCELKT--------------------CWR-AMPSFRKIGYMLKEKFDG-ACEVQQKKAGSRSVLVPR--------------------------------------------------------------------------------------------STQYK----PH----------SSTDLVYLVASPDFCERDPKT-GALGTHGRRC-------------NKT-SK---------AIDG-CELMC--CGRGYVTKKRVIIE-RCHCK-FH-----WCCYVKCQNCKREIEEHTCL</mol_seq>\r
3920                           <annotation ref="GO:0005578">\r
3921                             <desc>proteinaceous extracellular matrix</desc>\r
3922                           </annotation>\r
3923                           <annotation ref="GO:0007275">\r
3924                             <desc>multicellular organismal development</desc>\r
3925                           </annotation>\r
3926                           <annotation ref="GO:0016055">\r
3927                             <desc>Wnt signaling pathway</desc>\r
3928                           </annotation>\r
3929                         </sequence>\r
3930                       </clade>\r
3931                     </clade>\r
3932                     <clade>\r
3933                       <branch_length>0.01701</branch_length>\r
3934                       <confidence type="bootstrap">54</confidence>\r
3935                       <color>\r
3936                         <red>20</red>\r
3937                         <green>71</green>\r
3938                         <blue>142</blue>\r
3939                       </color>\r
3940                       <taxonomy>\r
3941                         <id provider="uniprot">7955</id>\r
3942                         <scientific_name>Danio rerio</scientific_name>\r
3943                         <common_name>Zebrafish</common_name>\r
3944                         <synonym>Brachydanio rerio</synonym>\r
3945                         <rank>species</rank>\r
3946                       </taxonomy>\r
3947                       <clade>\r
3948                         <name>Q1RLW9_DANRE/42-352</name>\r
3949                         <branch_length>0.0857</branch_length>\r
3950                         <color>\r
3951                           <red>20</red>\r
3952                           <green>71</green>\r
3953                           <blue>142</blue>\r
3954                         </color>\r
3955                         <taxonomy>\r
3956                           <id provider="uniprot">7955</id>\r
3957                           <code>DANRE</code>\r
3958                           <scientific_name>Danio rerio</scientific_name>\r
3959                           <common_name>Zebrafish</common_name>\r
3960                           <synonym>Brachydanio rerio</synonym>\r
3961                           <rank>species</rank>\r
3962                         </taxonomy>\r
3963                         <sequence type="protein">\r
3964                           <accession source="uniprot">Q1RLW9</accession>\r
3965                           <name>Protein Wnt</name>\r
3966                           <gene_name>wnt4a</gene_name>\r
3967                           <mol_seq is_aligned="true">TCEKLRGLI---QRQVQICKRNVE--------VMDAVRRGAQLAIDECQYQFRNRRWNCSTLESV---------------------------------PVFGK-VVTQG--TREAAFVYAISAASVAFAVTRACSSGEL-DKCGCDRNV--------------------HGVSPEG----------------------------------------------------------------------FQWSGCSDNI-AYGVAFSQSFVDIRER-----SKGQSSNRAL--MNLHNNEAGRKAILNHMRVECKCH---GVSGSCEVKT--------------------CWK-AMPPFRKVGNVIKEKFDG-ATEVELRKVGTTKVLVPR--------------------------------------------------------------------------------------------NSQFK----PH----------TDEDLVYLDPSPDFCEHDPRTPGIMGTAGRFC-------------NKT-SK---------AIDG-CELMC--CGRGFHTEEVEVVD-RCSCK-FH-----WCCYVKCKQCRKMVEMHTCR</mol_seq>\r
3968                           <annotation ref="GO:0005109">\r
3969                             <desc>frizzled binding</desc>\r
3970                           </annotation>\r
3971                           <annotation ref="GO:0005578">\r
3972                             <desc>proteinaceous extracellular matrix</desc>\r
3973                           </annotation>\r
3974                           <annotation ref="GO:0005615">\r
3975                             <desc>extracellular space</desc>\r
3976                           </annotation>\r
3977                           <annotation ref="GO:0007507">\r
3978                             <desc>heart development</desc>\r
3979                           </annotation>\r
3980                           <annotation ref="GO:0016055">\r
3981                             <desc>Wnt signaling pathway</desc>\r
3982                           </annotation>\r
3983                           <annotation ref="GO:0021986">\r
3984                             <desc>habenula development</desc>\r
3985                           </annotation>\r
3986                           <annotation ref="GO:0030182">\r
3987                             <desc>neuron differentiation</desc>\r
3988                           </annotation>\r
3989                           <annotation ref="GO:0042074">\r
3990                             <desc>cell migration involved in gastrulation</desc>\r
3991                           </annotation>\r
3992                           <annotation ref="GO:0045165">\r
3993                             <desc>cell fate commitment</desc>\r
3994                           </annotation>\r
3995                           <annotation ref="GO:0045893">\r
3996                             <desc>positive regulation of transcription, DNA-templated</desc>\r
3997                           </annotation>\r
3998                           <annotation ref="GO:0048841">\r
3999                             <desc>regulation of axon extension involved in axon guidance</desc>\r
4000                           </annotation>\r
4001                           <annotation ref="GO:0060070">\r
4002                             <desc>canonical Wnt signaling pathway</desc>\r
4003                           </annotation>\r
4004                           <annotation ref="GO:0070654">\r
4005                             <desc>sensory epithelium regeneration</desc>\r
4006                           </annotation>\r
4007                           <cross_references>\r
4008                             <accession source="CTD">30123</accession>\r
4009                             <accession source="KEGG">dre:30123</accession>\r
4010                             <accession source="NextBio">20806602</accession>\r
4011                           </cross_references>\r
4012                         </sequence>\r
4013                       </clade>\r
4014                       <clade>\r
4015                         <name>A3KQ12_DANRE/46-357</name>\r
4016                         <branch_length>0.10852</branch_length>\r
4017                         <color>\r
4018                           <red>20</red>\r
4019                           <green>71</green>\r
4020                           <blue>142</blue>\r
4021                         </color>\r
4022                         <taxonomy>\r
4023                           <id provider="uniprot">7955</id>\r
4024                           <code>DANRE</code>\r
4025                           <scientific_name>Danio rerio</scientific_name>\r
4026                           <common_name>Zebrafish</common_name>\r
4027                           <synonym>Brachydanio rerio</synonym>\r
4028                           <rank>species</rank>\r
4029                         </taxonomy>\r
4030                         <sequence type="protein">\r
4031                           <accession source="uniprot">A3KQ12</accession>\r
4032                           <name>Protein Wnt</name>\r
4033                           <gene_name>wnt4b</gene_name>\r
4034                           <mol_seq is_aligned="true">PCGRLRGLS---PGQVGVCRARGE--------VMESVRKASEMVIEECQHQFRNRRWNCSTTPRG--------------------------------INVFGR-VMNQG--TREAAFVHALSSAAVAVAVTRGCSRGEL-ERCGCDRKV--------------------RGVSPEG----------------------------------------------------------------------FQWSGCSDNL-SYGVAFSQTFVDEPER-----AKGMSSGRPL--MNIHNNEAGRKAILHNMQVECKCH---GVSGSCELRT--------------------CWK-VMPPFRRVGAVLKERFDG-ATEVRLTRVGSRTALLPR--------------------------------------------------------------------------------------------DPQVK----PP----------ATRDLVYLAPSPDFCRLDPDN-GIPGTAGRRC-------------NGT-SR--------LAPDG-CELLC--CGPGFRAGRAEVVQ-RCSCK-FS-----WCCSVRCQQCKNTVLIHTCR</mol_seq>\r
4035                           <annotation ref="GO:0005578">\r
4036                             <desc>proteinaceous extracellular matrix</desc>\r
4037                           </annotation>\r
4038                           <annotation ref="GO:0007275">\r
4039                             <desc>multicellular organismal development</desc>\r
4040                           </annotation>\r
4041                           <annotation ref="GO:0016055">\r
4042                             <desc>Wnt signaling pathway</desc>\r
4043                           </annotation>\r
4044                         </sequence>\r
4045                       </clade>\r
4046                     </clade>\r
4047                   </clade>\r
4048                   <clade>\r
4049                     <name>A2SVS6_9MOLL/48-358</name>\r
4050                     <branch_length>0.12714</branch_length>\r
4051                     <color>\r
4052                       <red>255</red>\r
4053                       <green>122</green>\r
4054                       <blue>142</blue>\r
4055                     </color>\r
4056                     <taxonomy>\r
4057                       <id provider="uniprot">6613</id>\r
4058                       <code>9MOLL</code>\r
4059                       <scientific_name>Euprymna scolopes</scientific_name>\r
4060                       <rank>phylum</rank>\r
4061                     </taxonomy>\r
4062                     <sequence type="protein">\r
4063                       <accession source="uniprot">A2SVS6</accession>\r
4064                       <name>Protein Wnt</name>\r
4065                       <mol_seq is_aligned="true">ECDNLTGLV---KRQKKICKKNLE--------MMNSVKQGAILAIQECQMQFRNRRWNCSSIDKL---------------------------------SLPGN-ILNRG--TREAAFVHAISAAAVAHSVTRACSSGKM-ERCGCDRTV-------------------HKNVTVQNS---------------------------------------------------------------------FLWSGCSDNV-AYGAAFSQRFVDARER------RRKINGRVL--MNLHNNQAGRNAIENHMKTMCKCH---GVSGACEMRT--------------------CWR-AILSFRKIGNLLREKFDG-ATEVRPKRKGSKRVLIPM--------------------------------------------------------------------------------------------NPKFK----HH----------TPNDLVYLLVSPDFCEPDNKT-GIPGTHGRLC-------------NLT-SK---------AIDG-CELMC--CGRGFNHRQRITSE-RCNCK-FN-----WCCVVECLMCPVVIEEFYCL</mol_seq>\r
4066                       <annotation ref="GO:0005578">\r
4067                         <desc>proteinaceous extracellular matrix</desc>\r
4068                       </annotation>\r
4069                       <annotation ref="GO:0007275">\r
4070                         <desc>multicellular organismal development</desc>\r
4071                       </annotation>\r
4072                       <annotation ref="GO:0016055">\r
4073                         <desc>Wnt signaling pathway</desc>\r
4074                       </annotation>\r
4075                     </sequence>\r
4076                   </clade>\r
4077                 </clade>\r
4078                 <clade>\r
4079                   <name>Q5IRC3_NEMVE/41-354</name>\r
4080                   <branch_length>0.14035</branch_length>\r
4081                   <color>\r
4082                     <red>20</red>\r
4083                     <green>132</green>\r
4084                     <blue>81</blue>\r
4085                   </color>\r
4086                   <taxonomy>\r
4087                     <id provider="uniprot">45351</id>\r
4088                     <code>NEMVE</code>\r
4089                     <scientific_name>Nematostella vectensis</scientific_name>\r
4090                     <common_name>Starlet sea anemone</common_name>\r
4091                     <rank>species</rank>\r
4092                   </taxonomy>\r
4093                   <sequence type="protein">\r
4094                     <accession source="uniprot">Q5IRC3</accession>\r
4095                     <name>Protein Wnt</name>\r
4096                     <mol_seq is_aligned="true">NCDEIGQLS--NHRQVQVCKRNIQ--------VMDSVKDGASVALFECQHQFRYRPWNCTTVQFSR-------------------------------SPVFGN-SINGG--TREAAFVHAISSAGVAYAVTQACSSGRLGQKCGCDRKT--------------------RGQADG-----------------------------------------------------------------------FNWGGCSDDI-DFGMTFATRFVDARERG----SGIGSPARVL--MNLHNNRGGRLAVRKFMDLQCKCH---GVSGSCNIKT--------------------CWR-ALPNFRIVGDYIKEKFDG-ATEVEYKLIGGKHVLVPK--------------------------------------------------------------------------------------------NRKYK----PH----------TQMDLVYLVQSPDFCEPNPKT-GSLGTQGRIC-------------NRT-SQ---------AIDG-CDLMC--CGRGYVSRTEVRQE-QCACK-FF-----WCCHVRCQTCMRRVEVSYCK</mol_seq>\r
4097                     <annotation ref="GO:0005578">\r
4098                       <desc>proteinaceous extracellular matrix</desc>\r
4099                     </annotation>\r
4100                     <annotation ref="GO:0007275">\r
4101                       <desc>multicellular organismal development</desc>\r
4102                     </annotation>\r
4103                     <annotation ref="GO:0016055">\r
4104                       <desc>Wnt signaling pathway</desc>\r
4105                     </annotation>\r
4106                   </sequence>\r
4107                 </clade>\r
4108               </clade>\r
4109               <clade>\r
4110                 <branch_length>0.01201</branch_length>\r
4111                 <confidence type="bootstrap">66</confidence>\r
4112                 <clade>\r
4113                   <branch_length>0.05249</branch_length>\r
4114                   <confidence type="bootstrap">100</confidence>\r
4115                   <color>\r
4116                     <red>20</red>\r
4117                     <green>71</green>\r
4118                     <blue>142</blue>\r
4119                   </color>\r
4120                   <taxonomy>\r
4121                     <id provider="uniprot">7711</id>\r
4122                     <scientific_name>Chordata</scientific_name>\r
4123                     <rank>phylum</rank>\r
4124                   </taxonomy>\r
4125                   <clade>\r
4126                     <branch_length>0.05276</branch_length>\r
4127                     <confidence type="bootstrap">100</confidence>\r
4128                     <color>\r
4129                       <red>20</red>\r
4130                       <green>71</green>\r
4131                       <blue>142</blue>\r
4132                     </color>\r
4133                     <taxonomy>\r
4134                       <id provider="uniprot">117571</id>\r
4135                       <scientific_name>Euteleostomi</scientific_name>\r
4136                     </taxonomy>\r
4137                     <clade>\r
4138                       <branch_length>0.02534</branch_length>\r
4139                       <confidence type="bootstrap">99</confidence>\r
4140                       <color>\r
4141                         <red>20</red>\r
4142                         <green>71</green>\r
4143                         <blue>142</blue>\r
4144                       </color>\r
4145                       <clade>\r
4146                         <name>WNT11_DANRE/43-354</name>\r
4147                         <branch_length>0.07896</branch_length>\r
4148                         <color>\r
4149                           <red>20</red>\r
4150                           <green>71</green>\r
4151                           <blue>142</blue>\r
4152                         </color>\r
4153                         <taxonomy>\r
4154                           <id provider="uniprot">7955</id>\r
4155                           <code>DANRE</code>\r
4156                           <scientific_name>Danio rerio</scientific_name>\r
4157                           <common_name>Zebrafish</common_name>\r
4158                           <synonym>Brachydanio rerio</synonym>\r
4159                           <rank>species</rank>\r
4160                         </taxonomy>\r
4161                         <sequence type="protein">\r
4162                           <accession source="uniprot">O73864</accession>\r
4163                           <name>Protein Wnt-11</name>\r
4164                           <gene_name>wnt11</gene_name>\r
4165                           <mol_seq is_aligned="true">HCKLLDGLV---PDQQQLCKRNLE--------LMHSIVRAARLTKSACTSSFSDMRWNWSSIESA---------------------------------PHFTP-DLAKG--TREAAFVVSLAAAVVSHAIARACASGDL-PSCSCAAMP--------------------SEQAAPD----------------------------------------------------------------------FRWGGCGDNLRYYGLQMGSAFSDAPMRN----RRSGPQDFRL--MQLHNNAVGRQVLMDSLEMKCKCH---GVSGSCSVKT--------------------CWK-GLQDISTISADLKSKYLS-ATKVIPRQIGTRRQLVPR--------------------------------------------------------------------------------------------EMEVR----PV----------GENELVYLVSSPDYCTQNAKQ-GSLGTTDRQC-------------NKT-AS---------GSES-CGLMC--CGRGYNAYTEVLVE-RCQCK-YH-----WCCYVSCKTCKRTVERYVSK</mol_seq>\r
4166                           <annotation ref="GO:0000132">\r
4167                             <desc>establishment of mitotic spindle orientation</desc>\r
4168                           </annotation>\r
4169                           <annotation ref="GO:0001702">\r
4170                             <desc>gastrulation with mouth forming second</desc>\r
4171                           </annotation>\r
4172                           <annotation ref="GO:0001839">\r
4173                             <desc>neural plate morphogenesis</desc>\r
4174                           </annotation>\r
4175                           <annotation ref="GO:0001947">\r
4176                             <desc>heart looping</desc>\r
4177                           </annotation>\r
4178                           <annotation ref="GO:0005099">\r
4179                             <desc>Ras GTPase activator activity</desc>\r
4180                           </annotation>\r
4181                           <annotation ref="GO:0005109">\r
4182                             <desc>frizzled binding</desc>\r
4183                           </annotation>\r
4184                           <annotation ref="GO:0005578">\r
4185                             <desc>proteinaceous extracellular matrix</desc>\r
4186                           </annotation>\r
4187                           <annotation ref="GO:0005615">\r
4188                             <desc>extracellular space</desc>\r
4189                           </annotation>\r
4190                           <annotation ref="GO:0005737">\r
4191                             <desc>cytoplasm</desc>\r
4192                           </annotation>\r
4193                           <annotation ref="GO:0005886">\r
4194                             <desc>plasma membrane</desc>\r
4195                           </annotation>\r
4196                           <annotation ref="GO:0006468">\r
4197                             <desc>protein phosphorylation</desc>\r
4198                           </annotation>\r
4199                           <annotation ref="GO:0007417">\r
4200                             <desc>central nervous system development</desc>\r
4201                           </annotation>\r
4202                           <annotation ref="GO:0007507">\r
4203                             <desc>heart development</desc>\r
4204                           </annotation>\r
4205                           <annotation ref="GO:0008078">\r
4206                             <desc>mesodermal cell migration</desc>\r
4207                           </annotation>\r
4208                           <annotation ref="GO:0008104">\r
4209                             <desc>protein localization</desc>\r
4210                           </annotation>\r
4211                           <annotation ref="GO:0010628">\r
4212                             <desc>positive regulation of gene expression</desc>\r
4213                           </annotation>\r
4214                           <annotation ref="GO:0016337">\r
4215                             <desc>single organismal cell-cell adhesion</desc>\r
4216                           </annotation>\r
4217                           <annotation ref="GO:0016477">\r
4218                             <desc>cell migration</desc>\r
4219                           </annotation>\r
4220                           <annotation ref="GO:0030100">\r
4221                             <desc>regulation of endocytosis</desc>\r
4222                           </annotation>\r
4223                           <annotation ref="GO:0030182">\r
4224                             <desc>neuron differentiation</desc>\r
4225                           </annotation>\r
4226                           <annotation ref="GO:0030295">\r
4227                             <desc>protein kinase activator activity</desc>\r
4228                           </annotation>\r
4229                           <annotation ref="GO:0030308">\r
4230                             <desc>negative regulation of cell growth</desc>\r
4231                           </annotation>\r
4232                           <annotation ref="GO:0030335">\r
4233                             <desc>positive regulation of cell migration</desc>\r
4234                           </annotation>\r
4235                           <annotation ref="GO:0030336">\r
4236                             <desc>negative regulation of cell migration</desc>\r
4237                           </annotation>\r
4238                           <annotation ref="GO:0032320">\r
4239                             <desc>positive regulation of Ras GTPase activity</desc>\r
4240                           </annotation>\r
4241                           <annotation ref="GO:0034394">\r
4242                             <desc>protein localization to cell surface</desc>\r
4243                           </annotation>\r
4244                           <annotation ref="GO:0035567">\r
4245                             <desc>non-canonical Wnt signaling pathway</desc>\r
4246                           </annotation>\r
4247                           <annotation ref="GO:0042074">\r
4248                             <desc>cell migration involved in gastrulation</desc>\r
4249                           </annotation>\r
4250                           <annotation ref="GO:0043010">\r
4251                             <desc>camera-type eye development</desc>\r
4252                           </annotation>\r
4253                           <annotation ref="GO:0043066">\r
4254                             <desc>negative regulation of apoptotic process</desc>\r
4255                           </annotation>\r
4256                           <annotation ref="GO:0044212">\r
4257                             <desc>transcription regulatory region DNA binding</desc>\r
4258                           </annotation>\r
4259                           <annotation ref="GO:0045859">\r
4260                             <desc>regulation of protein kinase activity</desc>\r
4261                           </annotation>\r
4262                           <annotation ref="GO:0045860">\r
4263                             <desc>positive regulation of protein kinase activity</desc>\r
4264                           </annotation>\r
4265                           <annotation ref="GO:0045892">\r
4266                             <desc>negative regulation of transcription, DNA-templated</desc>\r
4267                           </annotation>\r
4268                           <annotation ref="GO:0045893">\r
4269                             <desc>positive regulation of transcription, DNA-templated</desc>\r
4270                           </annotation>\r
4271                           <annotation ref="GO:0048048">\r
4272                             <desc>embryonic eye morphogenesis</desc>\r
4273                           </annotation>\r
4274                           <annotation ref="GO:0051496">\r
4275                             <desc>positive regulation of stress fiber assembly</desc>\r
4276                           </annotation>\r
4277                           <annotation ref="GO:0060021">\r
4278                             <desc>palate development</desc>\r
4279                           </annotation>\r
4280                           <annotation ref="GO:0060026">\r
4281                             <desc>convergent extension</desc>\r
4282                           </annotation>\r
4283                           <annotation ref="GO:0060027">\r
4284                             <desc>convergent extension involved in gastrulation</desc>\r
4285                           </annotation>\r
4286                           <annotation ref="GO:0060028">\r
4287                             <desc>convergent extension involved in axis elongation</desc>\r
4288                           </annotation>\r
4289                           <annotation ref="GO:0060031">\r
4290                             <desc>mediolateral intercalation</desc>\r
4291                           </annotation>\r
4292                           <annotation ref="GO:0060548">\r
4293                             <desc>negative regulation of cell death</desc>\r
4294                           </annotation>\r
4295                           <annotation ref="GO:0060898">\r
4296                             <desc>eye field cell fate commitment involved in camera-type eye formation</desc>\r
4297                           </annotation>\r
4298                           <annotation ref="GO:0061101">\r
4299                             <desc>neuroendocrine cell differentiation</desc>\r
4300                           </annotation>\r
4301                           <annotation ref="GO:0070121">\r
4302                             <desc>Kupffer&apos;s vesicle development</desc>\r
4303                           </annotation>\r
4304                           <annotation ref="GO:0090037">\r
4305                             <desc>positive regulation of protein kinase C signaling</desc>\r
4306                           </annotation>\r
4307                           <annotation ref="GO:0090090">\r
4308                             <desc>negative regulation of canonical Wnt signaling pathway</desc>\r
4309                           </annotation>\r
4310                         </sequence>\r
4311                       </clade>\r
4312                       <clade>\r
4313                         <name>WN11B_XENLA/42-353</name>\r
4314                         <branch_length>0.06668</branch_length>\r
4315                         <color>\r
4316                           <red>20</red>\r
4317                           <green>71</green>\r
4318                           <blue>142</blue>\r
4319                         </color>\r
4320                         <taxonomy>\r
4321                           <id provider="uniprot">8355</id>\r
4322                           <code>XENLA</code>\r
4323                           <scientific_name>Xenopus laevis</scientific_name>\r
4324                           <common_name>African clawed frog</common_name>\r
4325                           <rank>species</rank>\r
4326                         </taxonomy>\r
4327                         <sequence type="protein">\r
4328                           <symbol>XWnt-11</symbol>\r
4329                           <accession source="uniprot">P49893</accession>\r
4330                           <name>Protein Wnt-11b</name>\r
4331                           <gene_name>wnt11b</gene_name>\r
4332                           <mol_seq is_aligned="true">HCRLLDGLV---PDQSQLCKRNLE--------LMQSVVNAAKQTKLTCQMTLSDMRWNCSSVENA---------------------------------PSFTP-DLSKG--TRESAFVYALASATLSHTIARACASGEL-PTCSCGATP--------------------AEVPGTG----------------------------------------------------------------------FRWGGCGDNL-HYGLNMGSAFVDAPMKS---SKSAGTQATKI--MNLHNNAVGRQVLMDSLETKCKCH---GVSGSCSVKT--------------------CWK-GLQDLPHIANELKSKYLG-ATKVIHRQTGTRRQLVPR--------------------------------------------------------------------------------------------ELDIR----PV----------RESELVYLVSSPDYCTKNPKL-GSYGTQDRLC-------------NKT-SV---------GSDS-CNLMC--CGRGYNAYTETIVE-RCQCK-YH-----WCCYVMCKKCERTVERYVCK</mol_seq>\r
4333                           <annotation ref="GO:0001755">\r
4334                             <desc>neural crest cell migration</desc>\r
4335                           </annotation>\r
4336                           <annotation ref="GO:0005099">\r
4337                             <desc>Ras GTPase activator activity</desc>\r
4338                           </annotation>\r
4339                           <annotation ref="GO:0005109">\r
4340                             <desc>frizzled binding</desc>\r
4341                           </annotation>\r
4342                           <annotation ref="GO:0005515">\r
4343                             <desc>protein binding</desc>\r
4344                           </annotation>\r
4345                           <annotation ref="GO:0005576">\r
4346                             <desc>extracellular region</desc>\r
4347                           </annotation>\r
4348                           <annotation ref="GO:0005578">\r
4349                             <desc>proteinaceous extracellular matrix</desc>\r
4350                           </annotation>\r
4351                           <annotation ref="GO:0005615">\r
4352                             <desc>extracellular space</desc>\r
4353                           </annotation>\r
4354                           <annotation ref="GO:0005737">\r
4355                             <desc>cytoplasm</desc>\r
4356                           </annotation>\r
4357                           <annotation ref="GO:0005886">\r
4358                             <desc>plasma membrane</desc>\r
4359                           </annotation>\r
4360                           <annotation ref="GO:0006468">\r
4361                             <desc>protein phosphorylation</desc>\r
4362                           </annotation>\r
4363                           <annotation ref="GO:0006897">\r
4364                             <desc>endocytosis</desc>\r
4365                           </annotation>\r
4366                           <annotation ref="GO:0007507">\r
4367                             <desc>heart development</desc>\r
4368                           </annotation>\r
4369                           <annotation ref="GO:0009950">\r
4370                             <desc>dorsal/ventral axis specification</desc>\r
4371                           </annotation>\r
4372                           <annotation ref="GO:0010628">\r
4373                             <desc>positive regulation of gene expression</desc>\r
4374                           </annotation>\r
4375                           <annotation ref="GO:0016055">\r
4376                             <desc>Wnt signaling pathway</desc>\r
4377                           </annotation>\r
4378                           <annotation ref="GO:0017147">\r
4379                             <desc>Wnt-protein binding</desc>\r
4380                           </annotation>\r
4381                           <annotation ref="GO:0019838">\r
4382                             <desc>growth factor binding</desc>\r
4383                           </annotation>\r
4384                           <annotation ref="GO:0030295">\r
4385                             <desc>protein kinase activator activity</desc>\r
4386                           </annotation>\r
4387                           <annotation ref="GO:0030308">\r
4388                             <desc>negative regulation of cell growth</desc>\r
4389                           </annotation>\r
4390                           <annotation ref="GO:0030335">\r
4391                             <desc>positive regulation of cell migration</desc>\r
4392                           </annotation>\r
4393                           <annotation ref="GO:0030336">\r
4394                             <desc>negative regulation of cell migration</desc>\r
4395                           </annotation>\r
4396                           <annotation ref="GO:0032320">\r
4397                             <desc>positive regulation of Ras GTPase activity</desc>\r
4398                           </annotation>\r
4399                           <annotation ref="GO:0034394">\r
4400                             <desc>protein localization to cell surface</desc>\r
4401                           </annotation>\r
4402                           <annotation ref="GO:0035567">\r
4403                             <desc>non-canonical Wnt signaling pathway</desc>\r
4404                           </annotation>\r
4405                           <annotation ref="GO:0042074">\r
4406                             <desc>cell migration involved in gastrulation</desc>\r
4407                           </annotation>\r
4408                           <annotation ref="GO:0042803">\r
4409                             <desc>protein homodimerization activity</desc>\r
4410                           </annotation>\r
4411                           <annotation ref="GO:0043066">\r
4412                             <desc>negative regulation of apoptotic process</desc>\r
4413                           </annotation>\r
4414                           <annotation ref="GO:0043234">\r
4415                             <desc>protein complex</desc>\r
4416                           </annotation>\r
4417                           <annotation ref="GO:0044212">\r
4418                             <desc>transcription regulatory region DNA binding</desc>\r
4419                           </annotation>\r
4420                           <annotation ref="GO:0045860">\r
4421                             <desc>positive regulation of protein kinase activity</desc>\r
4422                           </annotation>\r
4423                           <annotation ref="GO:0045892">\r
4424                             <desc>negative regulation of transcription, DNA-templated</desc>\r
4425                           </annotation>\r
4426                           <annotation ref="GO:0045893">\r
4427                             <desc>positive regulation of transcription, DNA-templated</desc>\r
4428                           </annotation>\r
4429                           <annotation ref="GO:0046330">\r
4430                             <desc>positive regulation of JNK cascade</desc>\r
4431                           </annotation>\r
4432                           <annotation ref="GO:0048793">\r
4433                             <desc>pronephros development</desc>\r
4434                           </annotation>\r
4435                           <annotation ref="GO:0051496">\r
4436                             <desc>positive regulation of stress fiber assembly</desc>\r
4437                           </annotation>\r
4438                           <annotation ref="GO:0060021">\r
4439                             <desc>palate development</desc>\r
4440                           </annotation>\r
4441                           <annotation ref="GO:0060027">\r
4442                             <desc>convergent extension involved in gastrulation</desc>\r
4443                           </annotation>\r
4444                           <annotation ref="GO:0060070">\r
4445                             <desc>canonical Wnt signaling pathway</desc>\r
4446                           </annotation>\r
4447                           <annotation ref="GO:0060071">\r
4448                             <desc>Wnt signaling pathway, planar cell polarity pathway</desc>\r
4449                           </annotation>\r
4450                           <annotation ref="GO:0060548">\r
4451                             <desc>negative regulation of cell death</desc>\r
4452                           </annotation>\r
4453                           <annotation ref="GO:0060914">\r
4454                             <desc>heart formation</desc>\r
4455                           </annotation>\r
4456                           <annotation ref="GO:0061101">\r
4457                             <desc>neuroendocrine cell differentiation</desc>\r
4458                           </annotation>\r
4459                           <annotation ref="GO:0090037">\r
4460                             <desc>positive regulation of protein kinase C signaling</desc>\r
4461                           </annotation>\r
4462                           <annotation ref="GO:0090090">\r
4463                             <desc>negative regulation of canonical Wnt signaling pathway</desc>\r
4464                           </annotation>\r
4465                           <cross_references>\r
4466                             <accession source="CTD">399441</accession>\r
4467                             <accession source="KEGG">xla:399441</accession>\r
4468                           </cross_references>\r
4469                         </sequence>\r
4470                       </clade>\r
4471                     </clade>\r
4472                     <clade>\r
4473                       <name>Q9I9I2_DANRE/42-352</name>\r
4474                       <branch_length>0.09097</branch_length>\r
4475                       <color>\r
4476                         <red>20</red>\r
4477                         <green>71</green>\r
4478                         <blue>142</blue>\r
4479                       </color>\r
4480                       <taxonomy>\r
4481                         <id provider="uniprot">7955</id>\r
4482                         <code>DANRE</code>\r
4483                         <scientific_name>Danio rerio</scientific_name>\r
4484                         <common_name>Zebrafish</common_name>\r
4485                         <synonym>Brachydanio rerio</synonym>\r
4486                         <rank>species</rank>\r
4487                       </taxonomy>\r
4488                       <sequence type="protein">\r
4489                         <accession source="uniprot">Q9I9I2</accession>\r
4490                         <name>Protein Wnt</name>\r
4491                         <gene_name>wnt11r</gene_name>\r
4492                         <mol_seq is_aligned="true">HCKTLPGLV---SSQAQLCRSNLE--------LMQTIIQAAREVKKVCQKTFTDMRWNCSSIDG----------------------------------PKFLP-DLERG--TRESAFVYALSAAAISHTIARACTSGDL-RLCSCGPIP--------------------GEIPEPG----------------------------------------------------------------------YRWGGCADNI-HYGLLMGSKFSDAPMKM---KKKSGSHANKL--MHLHNSEVGRQALRDALVMKCKCH---GVSGSCSIRT--------------------CWR-GLLDLKDIAIDLKTKYLS-ATKVVHRPMGTRKQLVPK--------------------------------------------------------------------------------------------DIDIR----PV----------RENELVYLQSSPDYCMKNDKL-GSFGTQDRQC-------------NKT-SS---------GSDS-CDLMC--CGRGYNPYTERVVE-RCHCK-YH-----WCCYVTCKKCDKTVEKYVCK</mol_seq>\r
4493                         <annotation ref="GO:0001947">\r
4494                           <desc>heart looping</desc>\r
4495                         </annotation>\r
4496                         <annotation ref="GO:0005109">\r
4497                           <desc>frizzled binding</desc>\r
4498                         </annotation>\r
4499                         <annotation ref="GO:0005578">\r
4500                           <desc>proteinaceous extracellular matrix</desc>\r
4501                         </annotation>\r
4502                         <annotation ref="GO:0005615">\r
4503                           <desc>extracellular space</desc>\r
4504                         </annotation>\r
4505                         <annotation ref="GO:0007507">\r
4506                           <desc>heart development</desc>\r
4507                         </annotation>\r
4508                         <annotation ref="GO:0016055">\r
4509                           <desc>Wnt signaling pathway</desc>\r
4510                         </annotation>\r
4511                         <annotation ref="GO:0030182">\r
4512                           <desc>neuron differentiation</desc>\r
4513                         </annotation>\r
4514                         <annotation ref="GO:0042074">\r
4515                           <desc>cell migration involved in gastrulation</desc>\r
4516                         </annotation>\r
4517                         <annotation ref="GO:0045165">\r
4518                           <desc>cell fate commitment</desc>\r
4519                         </annotation>\r
4520                         <cross_references>\r
4521                           <accession source="CTD">30283</accession>\r
4522                           <accession source="KEGG">dre:30283</accession>\r
4523                           <accession source="NextBio">20806727</accession>\r
4524                         </cross_references>\r
4525                       </sequence>\r
4526                     </clade>\r
4527                   </clade>\r
4528                   <clade>\r
4529                     <name>Q9NCQ1_BRAFL/42-351</name>\r
4530                     <branch_length>0.13473</branch_length>\r
4531                     <color>\r
4532                       <red>20</red>\r
4533                       <green>71</green>\r
4534                       <blue>142</blue>\r
4535                     </color>\r
4536                     <taxonomy>\r
4537                       <id provider="uniprot">7739</id>\r
4538                       <code>BRAFL</code>\r
4539                       <scientific_name>Branchiostoma floridae</scientific_name>\r
4540                       <common_name>Florida lancelet</common_name>\r
4541                       <synonym>Amphioxus</synonym>\r
4542                       <rank>species</rank>\r
4543                     </taxonomy>\r
4544                     <sequence type="protein">\r
4545                       <accession source="uniprot">Q9NCQ1</accession>\r
4546                       <name>Protein Wnt</name>\r
4547                       <gene_name>Wnt11</gene_name>\r
4548                       <mol_seq is_aligned="true">SCRKVSGFV---PEQTQLCRRTLE--------VMPAVEYAAESARKTCQEQFGNRRWNCSSIKKA---------------------------------PHFMN-DLEKG--TKEAAYVHALSSAAVVHTVARACAAGYL-KACTCARNP--------------------GEKPDGN----------------------------------------------------------------------YTWGGCGDNV-KFGLEFGSRFADAPMR-----KKKRSHTQTL--MNLHNSEAGRLAVQNTMTTKCKCH---GVSGSCNVKT--------------------CWK-SLADLTEISHELAEKYSY-AIKVVKRKIGTRQQLVPE--------------------------------------------------------------------------------------------DRRSR----RH----------GSGDLIFVENSPNYCMVNNRK-GSYGTTGRLC-------------NKT-SV---------GPDS-CQTMC--CGRGYNDFTVTVTE-RCNCK-YH-----WCCYVTCDQCTRTEKKYMCK</mol_seq>\r
4549                       <annotation ref="GO:0005578">\r
4550                         <desc>proteinaceous extracellular matrix</desc>\r
4551                       </annotation>\r
4552                       <annotation ref="GO:0007275">\r
4553                         <desc>multicellular organismal development</desc>\r
4554                       </annotation>\r
4555                       <annotation ref="GO:0016055">\r
4556                         <desc>Wnt signaling pathway</desc>\r
4557                       </annotation>\r
4558                     </sequence>\r
4559                   </clade>\r
4560                 </clade>\r
4561                 <clade>\r
4562                   <name>Q5IRC2_NEMVE/39-352</name>\r
4563                   <branch_length>0.2089</branch_length>\r
4564                   <color>\r
4565                     <red>20</red>\r
4566                     <green>132</green>\r
4567                     <blue>81</blue>\r
4568                   </color>\r
4569                   <taxonomy>\r
4570                     <id provider="uniprot">45351</id>\r
4571                     <code>NEMVE</code>\r
4572                     <scientific_name>Nematostella vectensis</scientific_name>\r
4573                     <common_name>Starlet sea anemone</common_name>\r
4574                     <rank>species</rank>\r
4575                   </taxonomy>\r
4576                   <sequence type="protein">\r
4577                     <accession source="uniprot">Q5IRC2</accession>\r
4578                     <name>Protein Wnt</name>\r
4579                     <mol_seq is_aligned="true">DCNRIHGFS---GKQYKICRRNLP--------AMLYVTAAVEMTREECQHQFQNKRWNCSTIV--K-------------------------------APQFLP-DLKRG--TPEAAFVYALSAAALTYSITQACGMKRL-KPCKCGTNP--------------------KFKHPD-----------------------------------------------------------------------GEWGGCHDNI-ARGMRFSKDFTDAVEAQR--MRKHKSMAVAL--MNLHNNGVGRKAVHSRLEFHCRCH---GVSGGCTAKT--------------------CIR-RLGDFRLVADLLKNRYAR-IVYVESKTKSKRKAR-----------------------------------------------------------------------------------------------VLKSKRGRRRY----------TSSDLVALQGSPNYCHKNRKR-GTAGTHGRLC-------------DPT-KR---------RGEGSCAYLC--CGRGHRTEEVVHEE-RCECK-YI-----WCCYVKCQTCRKRVRESRCL</mol_seq>\r
4580                     <annotation ref="GO:0005578">\r
4581                       <desc>proteinaceous extracellular matrix</desc>\r
4582                     </annotation>\r
4583                     <annotation ref="GO:0007275">\r
4584                       <desc>multicellular organismal development</desc>\r
4585                     </annotation>\r
4586                     <annotation ref="GO:0016055">\r
4587                       <desc>Wnt signaling pathway</desc>\r
4588                     </annotation>\r
4589                   </sequence>\r
4590                 </clade>\r
4591               </clade>\r
4592             </clade>\r
4593           </clade>\r
4594         </clade>\r
4595         <clade>\r
4596           <name>Q5TS73_ANOGA/68-376</name>\r
4597           <branch_length>0.22168</branch_length>\r
4598           <color>\r
4599             <red>0</red>\r
4600             <green>173</green>\r
4601             <blue>193</blue>\r
4602           </color>\r
4603           <taxonomy>\r
4604             <id provider="uniprot">7165</id>\r
4605             <code>ANOGA</code>\r
4606             <scientific_name>Anopheles gambiae</scientific_name>\r
4607             <common_name>African malaria mosquito</common_name>\r
4608             <rank>species</rank>\r
4609           </taxonomy>\r
4610           <sequence type="protein">\r
4611             <accession source="uniprot">Q5TS73</accession>\r
4612             <name>Protein Wnt</name>\r
4613             <mol_seq is_aligned="true">LCGDTAFFT---EHQRDTCYSNPE--------LLKVIVHAANTAKYECQSYFQNNRWNCSAKRGS---------------------------------GIYYGNFDDKG--NRETAYLSAINSASLAWTITRFCTKGEL-TTCQCDRIP--------------------RNKHSTK----------------------------------------------------------------------WTWGGCSEDI-KYGIKQARSFTDPQE--------NRTTSFGL--MNLHNNEAARRILRSRMEKVCKCH---GMSGSCTTRV--------------------CWR-RLPPMKLIADTLGSLFDA-AAQVKPVENKGIIRKLMR-------------------------------------------------------------------------------------------KDLEYKK--V------------NKSDLVYIAESPNYCEENESL-GIFSTRGRFC-------------NRT-SY---------GIEG-CRLLC--CGRGYQTRIRNVEE-KCNCK-FV-----WCCSVKCDTCSMRKDEHICN</mol_seq>\r
4614             <annotation ref="GO:0005578">\r
4615               <desc>proteinaceous extracellular matrix</desc>\r
4616             </annotation>\r
4617             <annotation ref="GO:0007275">\r
4618               <desc>multicellular organismal development</desc>\r
4619             </annotation>\r
4620             <annotation ref="GO:0016055">\r
4621               <desc>Wnt signaling pathway</desc>\r
4622             </annotation>\r
4623           </sequence>\r
4624         </clade>\r
4625       </clade>\r
4626       <clade>\r
4627         <branch_length>0.0143</branch_length>\r
4628         <confidence type="bootstrap">71</confidence>\r
4629         <clade>\r
4630           <branch_length>0.00663</branch_length>\r
4631           <confidence type="bootstrap">49</confidence>\r
4632           <clade>\r
4633             <name>A1DYI3_CHICK/44-355</name>\r
4634             <branch_length>0.15137</branch_length>\r
4635             <color>\r
4636               <red>20</red>\r
4637               <green>71</green>\r
4638               <blue>142</blue>\r
4639             </color>\r
4640             <taxonomy>\r
4641               <id provider="uniprot">9031</id>\r
4642               <code>CHICK</code>\r
4643               <scientific_name>Gallus gallus</scientific_name>\r
4644               <common_name>Chicken</common_name>\r
4645               <rank>species</rank>\r
4646             </taxonomy>\r
4647             <sequence type="protein">\r
4648               <accession source="uniprot">A1DYI3</accession>\r
4649               <name>Protein Wnt</name>\r
4650               <gene_name>Wnt3</gene_name>\r
4651               <mol_seq is_aligned="true">LCGSIPGLV---PKQLRFCRNYIE--------IMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDS--------------------------------LAIFGP-VLDKA--TRESAFVHAIASAGVAFAVTRSCAEGTS-TICGCDSHH--------------------KGPPGEG----------------------------------------------------------------------WKWGGCSEDA-DFGVLVSREFADARE--------NRPDARSA--MNRHNNEAGRTTILDHMHLKCKCH---GLSGSCEVKT--------------------CWW-AQPDFRAIGDYLKDKYDS-ASEMVVEKHRESRGWVETL---------------------------------------------------------------------RA-------------------KYALFK----PP----------TERDLVYYENSPNFCEPNPET-GSFGTRDRTC-------------NVT-SH---------GIDG-CDLLC--CGRGHNTRTEKRKE-KCHCI-FH-----WCCYVSCQECIRVYDVHTCK</mol_seq>\r
4652               <annotation ref="GO:0001707">\r
4653                 <desc>mesoderm formation</desc>\r
4654               </annotation>\r
4655               <annotation ref="GO:0005578">\r
4656                 <desc>proteinaceous extracellular matrix</desc>\r
4657               </annotation>\r
4658               <annotation ref="GO:0007411">\r
4659                 <desc>axon guidance</desc>\r
4660               </annotation>\r
4661               <annotation ref="GO:0009948">\r
4662                 <desc>anterior/posterior axis specification</desc>\r
4663               </annotation>\r
4664               <annotation ref="GO:0009950">\r
4665                 <desc>dorsal/ventral axis specification</desc>\r
4666               </annotation>\r
4667               <annotation ref="GO:0010628">\r
4668                 <desc>positive regulation of gene expression</desc>\r
4669               </annotation>\r
4670               <annotation ref="GO:0035115">\r
4671                 <desc>embryonic forelimb morphogenesis</desc>\r
4672               </annotation>\r
4673               <annotation ref="GO:0035116">\r
4674                 <desc>embryonic hindlimb morphogenesis</desc>\r
4675               </annotation>\r
4676               <annotation ref="GO:0044338">\r
4677                 <desc>canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation</desc>\r
4678               </annotation>\r
4679               <annotation ref="GO:0044339">\r
4680                 <desc>canonical Wnt signaling pathway involved in osteoblast differentiation</desc>\r
4681               </annotation>\r
4682               <annotation ref="GO:0048697">\r
4683                 <desc>positive regulation of collateral sprouting in absence of injury</desc>\r
4684               </annotation>\r
4685               <annotation ref="GO:0048843">\r
4686                 <desc>negative regulation of axon extension involved in axon guidance</desc>\r
4687               </annotation>\r
4688               <annotation ref="GO:0060064">\r
4689                 <desc>Spemann organizer formation at the anterior end of the primitive streak</desc>\r
4690               </annotation>\r
4691               <annotation ref="GO:0060174">\r
4692                 <desc>limb bud formation</desc>\r
4693               </annotation>\r
4694               <annotation ref="GO:0060323">\r
4695                 <desc>head morphogenesis</desc>\r
4696               </annotation>\r
4697               <annotation ref="GO:0061180">\r
4698                 <desc>mammary gland epithelium development</desc>\r
4699               </annotation>\r
4700               <cross_references>\r
4701                 <accession source="CTD">7473</accession>\r
4702                 <accession source="KEGG">gga:374142</accession>\r
4703                 <accession source="NextBio">20813657</accession>\r
4704               </cross_references>\r
4705             </sequence>\r
4706           </clade>\r
4707           <clade>\r
4708             <name>Q9GTJ9_HYDVU/47-363</name>\r
4709             <branch_length>0.19186</branch_length>\r
4710             <color>\r
4711               <red>20</red>\r
4712               <green>132</green>\r
4713               <blue>81</blue>\r
4714             </color>\r
4715             <taxonomy>\r
4716               <id provider="uniprot">6087</id>\r
4717               <code>HYDVU</code>\r
4718               <scientific_name>Hydra vulgaris</scientific_name>\r
4719               <common_name>Hydra</common_name>\r
4720               <synonym>Hydra attenuata</synonym>\r
4721               <rank>species</rank>\r
4722             </taxonomy>\r
4723             <sequence type="protein">\r
4724               <accession source="uniprot">Q9GTJ9</accession>\r
4725               <name>Protein Wnt</name>\r
4726               <gene_name>WNT3</gene_name>\r
4727               <mol_seq is_aligned="true">LCRALYLHH----YQRTVCLNYTD--------LMLSVAEGIRLGIDECQVQFKHRKWNCTINEHG--------------------------------TSVFGP-IITTA--SRESAFISGIISAGVAFSVTESCAEGKS-VHCRCDNSV--------------------RGQTDEG----------------------------------------------------------------------WRWGGCNRPI-TYGIWFSQLFIDQVEKI----VKKRKDPRKI--MNLHNNKAGREVIKNLLQTECKCH---GTSGNCNLKT--------------------CWR-SQPHFSEIGKILKEKYDS-AHEMEFLYKVKANGERKIK----------------------------------------------------------------------D-------------------LIPKYKE-YLPP----------SSLDFIYYEESPNYCVKNETL-GIAGTKGRSC-------------NIT-SS---------GVDG-CELMC--CQRGYNVNIVQKTH-SCECK-FV-----WCCKVSCNSCIKMTPEYTCK</mol_seq>\r
4728               <annotation ref="GO:0005578">\r
4729                 <desc>proteinaceous extracellular matrix</desc>\r
4730               </annotation>\r
4731               <annotation ref="GO:0007275">\r
4732                 <desc>multicellular organismal development</desc>\r
4733               </annotation>\r
4734               <annotation ref="GO:0016055">\r
4735                 <desc>Wnt signaling pathway</desc>\r
4736               </annotation>\r
4737               <cross_references>\r
4738                 <accession source="KEGG">hmg:100203050</accession>\r
4739               </cross_references>\r
4740             </sequence>\r
4741           </clade>\r
4742         </clade>\r
4743         <clade>\r
4744           <name>A7RXF5_NEMVE/41-349</name>\r
4745           <branch_length>0.16164</branch_length>\r
4746           <color>\r
4747             <red>20</red>\r
4748             <green>132</green>\r
4749             <blue>81</blue>\r
4750           </color>\r
4751           <taxonomy>\r
4752             <id provider="uniprot">45351</id>\r
4753             <code>NEMVE</code>\r
4754             <scientific_name>Nematostella vectensis</scientific_name>\r
4755             <common_name>Starlet sea anemone</common_name>\r
4756             <rank>species</rank>\r
4757           </taxonomy>\r
4758           <sequence type="protein">\r
4759             <accession source="uniprot">A7RXF5</accession>\r
4760             <name>Protein Wnt</name>\r
4761             <mol_seq is_aligned="true">LCYVTRQFN---SRQQEVCRKNPD--------LMEHVAHGAKYGVHECRHQFRNRRWNCSTIRES--------------------------------GSLFES-VLSKG--CREAAFVHAVTAAGVAHSVTDACSKGRI-ESCDCDRNL--------------------SGRSSKG----------------------------------------------------------------------WTWSGCNSNI-KFGVWFSKQFTEARE--------RGGDLRQI--MNRHNSRAGRKALEELVWRKCKCH---GLSGSCSMKT--------------------CWM-QQANFRQIGDHLKVKYDS-AVEMTTKVNRRGKKRLKP-------------------------------------------------------------------------------------------KYSHFK----KP----------SDKDLIYFETSPNYCDKNVTV-GSLGTSGRQC-------------NYT-SN---------GIDG-CELLC--CGRGHNIQQAKITR-NCNCV-FK-----WCCEVKCERCKEVVNIYTCK</mol_seq>\r
4762             <annotation ref="GO:0005578">\r
4763               <desc>proteinaceous extracellular matrix</desc>\r
4764             </annotation>\r
4765             <annotation ref="GO:0007275">\r
4766               <desc>multicellular organismal development</desc>\r
4767             </annotation>\r
4768             <annotation ref="GO:0016055">\r
4769               <desc>Wnt signaling pathway</desc>\r
4770             </annotation>\r
4771           </sequence>\r
4772         </clade>\r
4773       </clade>\r
4774     </clade>\r
4775     <clade>\r
4776       <branch_length>0.014705</branch_length>\r
4777       <confidence type="bootstrap">99</confidence>\r
4778       <clade>\r
4779         <branch_length>0.02456</branch_length>\r
4780         <confidence type="bootstrap">100</confidence>\r
4781         <clade>\r
4782           <branch_length>0.01307</branch_length>\r
4783           <confidence type="bootstrap">90</confidence>\r
4784           <clade>\r
4785             <branch_length>0.00711</branch_length>\r
4786             <confidence type="bootstrap">58</confidence>\r
4787             <clade>\r
4788               <branch_length>0.00898</branch_length>\r
4789               <confidence type="bootstrap">51</confidence>\r
4790               <clade>\r
4791                 <branch_length>0.08224</branch_length>\r
4792                 <confidence type="bootstrap">100</confidence>\r
4793                 <color>\r
4794                   <red>0</red>\r
4795                   <green>173</green>\r
4796                   <blue>193</blue>\r
4797                 </color>\r
4798                 <taxonomy>\r
4799                   <id provider="uniprot">33340</id>\r
4800                   <scientific_name>Neoptera</scientific_name>\r
4801                   <rank>subclass</rank>\r
4802                 </taxonomy>\r
4803                 <clade>\r
4804                   <branch_length>0.03803</branch_length>\r
4805                   <confidence type="bootstrap">98</confidence>\r
4806                   <color>\r
4807                     <red>0</red>\r
4808                     <green>173</green>\r
4809                     <blue>193</blue>\r
4810                   </color>\r
4811                   <taxonomy>\r
4812                     <id provider="uniprot">33392</id>\r
4813                     <scientific_name>Endopterygota</scientific_name>\r
4814                     <rank>infraclass</rank>\r
4815                   </taxonomy>\r
4816                   <clade>\r
4817                     <branch_length>0.14138</branch_length>\r
4818                     <confidence type="bootstrap">100</confidence>\r
4819                     <color>\r
4820                       <red>0</red>\r
4821                       <green>173</green>\r
4822                       <blue>193</blue>\r
4823                     </color>\r
4824                     <taxonomy>\r
4825                       <id provider="uniprot">7147</id>\r
4826                       <scientific_name>Diptera</scientific_name>\r
4827                       <rank>order</rank>\r
4828                     </taxonomy>\r
4829                     <clade>\r
4830                       <name>Q16S09_AEDAE/31-428</name>\r
4831                       <branch_length>0.09724</branch_length>\r
4832                       <color>\r
4833                         <red>0</red>\r
4834                         <green>173</green>\r
4835                         <blue>193</blue>\r
4836                       </color>\r
4837                       <taxonomy>\r
4838                         <id provider="uniprot">7159</id>\r
4839                         <code>AEDAE</code>\r
4840                         <scientific_name>Aedes aegypti</scientific_name>\r
4841                         <common_name>Yellowfever mosquito</common_name>\r
4842                         <synonym>Culex aegypti</synonym>\r
4843                         <rank>species</rank>\r
4844                       </taxonomy>\r
4845                       <sequence type="protein">\r
4846                         <accession source="uniprot">Q16S09</accession>\r
4847                         <name>Protein Wnt</name>\r
4848                         <mol_seq is_aligned="true">MDPAIHATL--RRKQRRLARENPG--------VLAAIAKGANMAINECQHQFRNRRWNCSTRNFLR------------------------------GKNLFGK-IVERG--CRETAFIYAITSAAVTHSIARACSEGSI-ESCTCDYSHQSRAP---------QASTMGAVAGVRD----------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE--------RGRTLREK--MNLHNNEAGRAHVQSEMRQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRVVGDLLKDRFDG-ASRVMVSNSLRTSVNEA-TLSNRANPNGLKAQNQLGGSSPGGPNSV---------------SSNSIHARSHQQKKINRSFGDFQRWTKFLSKIFEFPSSINRYNFQLKPHNPDHK----PP----------GTKDLVYLEPSPGFCDRNPRL-GIQGTHGRQC-------------NDT-SI---------GVDG-CDLMC--CGRGYRTQEVIVVE-RCACT-FH-----WCCEVKCKLCRTKKIIHTCL</mol_seq>\r
4849                         <annotation ref="GO:0005578">\r
4850                           <desc>proteinaceous extracellular matrix</desc>\r
4851                         </annotation>\r
4852                         <annotation ref="GO:0007275">\r
4853                           <desc>multicellular organismal development</desc>\r
4854                         </annotation>\r
4855                         <annotation ref="GO:0016055">\r
4856                           <desc>Wnt signaling pathway</desc>\r
4857                         </annotation>\r
4858                       </sequence>\r
4859                     </clade>\r
4860                     <clade>\r
4861                       <name>WNTG_DROME/56-468</name>\r
4862                       <branch_length>0.23847</branch_length>\r
4863                       <color>\r
4864                         <red>0</red>\r
4865                         <green>173</green>\r
4866                         <blue>193</blue>\r
4867                       </color>\r
4868                       <taxonomy>\r
4869                         <id provider="uniprot">7227</id>\r
4870                         <code>DROME</code>\r
4871                         <scientific_name>Drosophila melanogaster</scientific_name>\r
4872                         <common_name>Fruit fly</common_name>\r
4873                         <rank>species</rank>\r
4874                       </taxonomy>\r
4875                       <sequence type="protein">\r
4876                         <accession source="uniprot">P09615</accession>\r
4877                         <name>Protein wingless</name>\r
4878                         <gene_name>wg</gene_name>\r
4879                         <mol_seq is_aligned="true">MDPAIHSTL--RRKQRRLVRDNPG--------VLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLF--------------------GKIVDRG-------------CRETSFIYAITSAAVTHSIARACSEGTI-ESCTCDYSHQSRSP---------QANHQAGSVAGVRD---------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE----------RGRNLREKMNLHNNEAGRAHVQAEMRQECKCH---GMSGSCTVKT--------------------CWM-RLANFRVIGDNLKARFDG-ATRVQVTNSLR-ATNAL-APVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHK----PP----------GSKDLVYLEPSPSFCEKNLRQ-GILGTHGRQC-------------NET-SL---------GVDG-CGLMC--CGRGYRRDEVVVVE-RCACTFH------WCCEVKCKLCRTKKVIYTCL</mol_seq>\r
4880                         <annotation ref="GO:0001745">\r
4881                           <desc>compound eye morphogenesis</desc>\r
4882                         </annotation>\r
4883                         <annotation ref="GO:0002168">\r
4884                           <desc>instar larval development</desc>\r
4885                         </annotation>\r
4886                         <annotation ref="GO:0003136">\r
4887                           <desc>negative regulation of heart induction by canonical Wnt signaling pathway</desc>\r
4888                         </annotation>\r
4889                         <annotation ref="GO:0005109">\r
4890                           <desc>frizzled binding</desc>\r
4891                         </annotation>\r
4892                         <annotation ref="GO:0005110">\r
4893                           <desc>frizzled-2 binding</desc>\r
4894                         </annotation>\r
4895                         <annotation ref="GO:0005112">\r
4896                           <desc>Notch binding</desc>\r
4897                         </annotation>\r
4898                         <annotation ref="GO:0005515">\r
4899                           <desc>protein binding</desc>\r
4900                         </annotation>\r
4901                         <annotation ref="GO:0005539">\r
4902                           <desc>glycosaminoglycan binding</desc>\r
4903                         </annotation>\r
4904                         <annotation ref="GO:0005576">\r
4905                           <desc>extracellular region</desc>\r
4906                         </annotation>\r
4907                         <annotation ref="GO:0005578">\r
4908                           <desc>proteinaceous extracellular matrix</desc>\r
4909                         </annotation>\r
4910                         <annotation ref="GO:0005615">\r
4911                           <desc>extracellular space</desc>\r
4912                         </annotation>\r
4913                         <annotation ref="GO:0005771">\r
4914                           <desc>multivesicular body</desc>\r
4915                         </annotation>\r
4916                         <annotation ref="GO:0005783">\r
4917                           <desc>endoplasmic reticulum</desc>\r
4918                         </annotation>\r
4919                         <annotation ref="GO:0005886">\r
4920                           <desc>plasma membrane</desc>\r
4921                         </annotation>\r
4922                         <annotation ref="GO:0006355">\r
4923                           <desc>regulation of transcription, DNA-templated</desc>\r
4924                         </annotation>\r
4925                         <annotation ref="GO:0007223">\r
4926                           <desc>Wnt signaling pathway, calcium modulating pathway</desc>\r
4927                         </annotation>\r
4928                         <annotation ref="GO:0007346">\r
4929                           <desc>regulation of mitotic cell cycle</desc>\r
4930                         </annotation>\r
4931                         <annotation ref="GO:0007367">\r
4932                           <desc>segment polarity determination</desc>\r
4933                         </annotation>\r
4934                         <annotation ref="GO:0007391">\r
4935                           <desc>dorsal closure</desc>\r
4936                         </annotation>\r
4937                         <annotation ref="GO:0007394">\r
4938                           <desc>dorsal closure, elongation of leading edge cells</desc>\r
4939                         </annotation>\r
4940                         <annotation ref="GO:0007398">\r
4941                           <desc>ectoderm development</desc>\r
4942                         </annotation>\r
4943                         <annotation ref="GO:0007418">\r
4944                           <desc>ventral midline development</desc>\r
4945                         </annotation>\r
4946                         <annotation ref="GO:0007419">\r
4947                           <desc>ventral cord development</desc>\r
4948                         </annotation>\r
4949                         <annotation ref="GO:0007423">\r
4950                           <desc>sensory organ development</desc>\r
4951                         </annotation>\r
4952                         <annotation ref="GO:0007442">\r
4953                           <desc>hindgut morphogenesis</desc>\r
4954                         </annotation>\r
4955                         <annotation ref="GO:0007444">\r
4956                           <desc>imaginal disc development</desc>\r
4957                         </annotation>\r
4958                         <annotation ref="GO:0007446">\r
4959                           <desc>imaginal disc growth</desc>\r
4960                         </annotation>\r
4961                         <annotation ref="GO:0007447">\r
4962                           <desc>imaginal disc pattern formation</desc>\r
4963                         </annotation>\r
4964                         <annotation ref="GO:0007448">\r
4965                           <desc>anterior/posterior pattern specification, imaginal disc</desc>\r
4966                         </annotation>\r
4967                         <annotation ref="GO:0007450">\r
4968                           <desc>dorsal/ventral pattern formation, imaginal disc</desc>\r
4969                         </annotation>\r
4970                         <annotation ref="GO:0007476">\r
4971                           <desc>imaginal disc-derived wing morphogenesis</desc>\r
4972                         </annotation>\r
4973                         <annotation ref="GO:0007479">\r
4974                           <desc>leg disc proximal/distal pattern formation</desc>\r
4975                         </annotation>\r
4976                         <annotation ref="GO:0007498">\r
4977                           <desc>mesoderm development</desc>\r
4978                         </annotation>\r
4979                         <annotation ref="GO:0007507">\r
4980                           <desc>heart development</desc>\r
4981                         </annotation>\r
4982                         <annotation ref="GO:0007523">\r
4983                           <desc>larval visceral muscle development</desc>\r
4984                         </annotation>\r
4985                         <annotation ref="GO:0007616">\r
4986                           <desc>long-term memory</desc>\r
4987                         </annotation>\r
4988                         <annotation ref="GO:0008284">\r
4989                           <desc>positive regulation of cell proliferation</desc>\r
4990                         </annotation>\r
4991                         <annotation ref="GO:0008544">\r
4992                           <desc>epidermis development</desc>\r
4993                         </annotation>\r
4994                         <annotation ref="GO:0008595">\r
4995                           <desc>anterior/posterior axis specification, embryo</desc>\r
4996                         </annotation>\r
4997                         <annotation ref="GO:0009986">\r
4998                           <desc>cell surface</desc>\r
4999                         </annotation>\r
5000                         <annotation ref="GO:0009996">\r
5001                           <desc>negative regulation of cell fate specification</desc>\r
5002                         </annotation>\r
5003                         <annotation ref="GO:0010002">\r
5004                           <desc>cardioblast differentiation</desc>\r
5005                         </annotation>\r
5006                         <annotation ref="GO:0014019">\r
5007                           <desc>neuroblast development</desc>\r
5008                         </annotation>\r
5009                         <annotation ref="GO:0016015">\r
5010                           <desc>morphogen activity</desc>\r
5011                         </annotation>\r
5012                         <annotation ref="GO:0016023">\r
5013                           <desc>cytoplasmic membrane-bounded vesicle</desc>\r
5014                         </annotation>\r
5015                         <annotation ref="GO:0016318">\r
5016                           <desc>ommatidial rotation</desc>\r
5017                         </annotation>\r
5018                         <annotation ref="GO:0030032">\r
5019                           <desc>lamellipodium assembly</desc>\r
5020                         </annotation>\r
5021                         <annotation ref="GO:0030054">\r
5022                           <desc>cell junction</desc>\r
5023                         </annotation>\r
5024                         <annotation ref="GO:0030139">\r
5025                           <desc>endocytic vesicle</desc>\r
5026                         </annotation>\r
5027                         <annotation ref="GO:0030182">\r
5028                           <desc>neuron differentiation</desc>\r
5029                         </annotation>\r
5030                         <annotation ref="GO:0030707">\r
5031                           <desc>ovarian follicle cell development</desc>\r
5032                         </annotation>\r
5033                         <annotation ref="GO:0032876">\r
5034                           <desc>negative regulation of DNA endoreduplication</desc>\r
5035                         </annotation>\r
5036                         <annotation ref="GO:0035017">\r
5037                           <desc>cuticle pattern formation</desc>\r
5038                         </annotation>\r
5039                         <annotation ref="GO:0035147">\r
5040                           <desc>branch fusion, open tracheal system</desc>\r
5041                         </annotation>\r
5042                         <annotation ref="GO:0035153">\r
5043                           <desc>epithelial cell type specification, open tracheal system</desc>\r
5044                         </annotation>\r
5045                         <annotation ref="GO:0035167">\r
5046                           <desc>larval lymph gland hemopoiesis</desc>\r
5047                         </annotation>\r
5048                         <annotation ref="GO:0035170">\r
5049                           <desc>lymph gland crystal cell differentiation</desc>\r
5050                         </annotation>\r
5051                         <annotation ref="GO:0035215">\r
5052                           <desc>genital disc development</desc>\r
5053                         </annotation>\r
5054                         <annotation ref="GO:0035217">\r
5055                           <desc>labial disc development</desc>\r
5056                         </annotation>\r
5057                         <annotation ref="GO:0035220">\r
5058                           <desc>wing disc development</desc>\r
5059                         </annotation>\r
5060                         <annotation ref="GO:0035224">\r
5061                           <desc>genital disc anterior/posterior pattern formation</desc>\r
5062                         </annotation>\r
5063                         <annotation ref="GO:0035225">\r
5064                           <desc>determination of genital disc primordium</desc>\r
5065                         </annotation>\r
5066                         <annotation ref="GO:0035263">\r
5067                           <desc>genital disc sexually dimorphic development</desc>\r
5068                         </annotation>\r
5069                         <annotation ref="GO:0035277">\r
5070                           <desc>spiracle morphogenesis, open tracheal system</desc>\r
5071                         </annotation>\r
5072                         <annotation ref="GO:0035288">\r
5073                           <desc>anterior head segmentation</desc>\r
5074                         </annotation>\r
5075                         <annotation ref="GO:0035289">\r
5076                           <desc>posterior head segmentation</desc>\r
5077                         </annotation>\r
5078                         <annotation ref="GO:0035290">\r
5079                           <desc>trunk segmentation</desc>\r
5080                         </annotation>\r
5081                         <annotation ref="GO:0035311">\r
5082                           <desc>wing cell fate specification</desc>\r
5083                         </annotation>\r
5084                         <annotation ref="GO:0042127">\r
5085                           <desc>regulation of cell proliferation</desc>\r
5086                         </annotation>\r
5087                         <annotation ref="GO:0042691">\r
5088                           <desc>positive regulation of crystal cell differentiation</desc>\r
5089                         </annotation>\r
5090                         <annotation ref="GO:0043066">\r
5091                           <desc>negative regulation of apoptotic process</desc>\r
5092                         </annotation>\r
5093                         <annotation ref="GO:0044719">\r
5094                           <desc>regulation of imaginal disc-derived wing size</desc>\r
5095                         </annotation>\r
5096                         <annotation ref="GO:0045121">\r
5097                           <desc>membrane raft</desc>\r
5098                         </annotation>\r
5099                         <annotation ref="GO:0045202">\r
5100                           <desc>synapse</desc>\r
5101                         </annotation>\r
5102                         <annotation ref="GO:0045611">\r
5103                           <desc>negative regulation of hemocyte differentiation</desc>\r
5104                         </annotation>\r
5105                         <annotation ref="GO:0045892">\r
5106                           <desc>negative regulation of transcription, DNA-templated</desc>\r
5107                         </annotation>\r
5108                         <annotation ref="GO:0046672">\r
5109                           <desc>positive regulation of compound eye retinal cell programmed cell death</desc>\r
5110                         </annotation>\r
5111                         <annotation ref="GO:0046847">\r
5112                           <desc>filopodium assembly</desc>\r
5113                         </annotation>\r
5114                         <annotation ref="GO:0048076">\r
5115                           <desc>regulation of compound eye pigmentation</desc>\r
5116                         </annotation>\r
5117                         <annotation ref="GO:0048190">\r
5118                           <desc>wing disc dorsal/ventral pattern formation</desc>\r
5119                         </annotation>\r
5120                         <annotation ref="GO:0048332">\r
5121                           <desc>mesoderm morphogenesis</desc>\r
5122                         </annotation>\r
5123                         <annotation ref="GO:0048542">\r
5124                           <desc>lymph gland development</desc>\r
5125                         </annotation>\r
5126                         <annotation ref="GO:0048728">\r
5127                           <desc>proboscis development</desc>\r
5128                         </annotation>\r
5129                         <annotation ref="GO:0048749">\r
5130                           <desc>compound eye development</desc>\r
5131                         </annotation>\r
5132                         <annotation ref="GO:0048754">\r
5133                           <desc>branching morphogenesis of an epithelial tube</desc>\r
5134                         </annotation>\r
5135                         <annotation ref="GO:0050840">\r
5136                           <desc>extracellular matrix binding</desc>\r
5137                         </annotation>\r
5138                         <annotation ref="GO:0051017">\r
5139                           <desc>actin filament bundle assembly</desc>\r
5140                         </annotation>\r
5141                         <annotation ref="GO:0060061">\r
5142                           <desc>Spemann organizer formation</desc>\r
5143                         </annotation>\r
5144                         <annotation ref="GO:0060070">\r
5145                           <desc>canonical Wnt signaling pathway</desc>\r
5146                         </annotation>\r
5147                         <annotation ref="GO:0060914">\r
5148                           <desc>heart formation</desc>\r
5149                         </annotation>\r
5150                         <annotation ref="GO:0061320">\r
5151                           <desc>pericardial nephrocyte differentiation</desc>\r
5152                         </annotation>\r
5153                         <annotation ref="GO:0061328">\r
5154                           <desc>posterior Malpighian tubule development</desc>\r
5155                         </annotation>\r
5156                         <annotation ref="GO:0061331">\r
5157                           <desc>epithelial cell proliferation involved in Malpighian tubule morphogenesis</desc>\r
5158                         </annotation>\r
5159                         <annotation ref="GO:0061332">\r
5160                           <desc>Malpighian tubule bud morphogenesis</desc>\r
5161                         </annotation>\r
5162                         <annotation ref="GO:0061382">\r
5163                           <desc>Malpighian tubule tip cell differentiation</desc>\r
5164                         </annotation>\r
5165                         <annotation ref="GO:0072091">\r
5166                           <desc>regulation of stem cell proliferation</desc>\r
5167                         </annotation>\r
5168                         <cross_references>\r
5169                           <accession source="CTD">474168</accession>\r
5170                           <accession source="NextBio">786411</accession>\r
5171                         </cross_references>\r
5172                       </sequence>\r
5173                     </clade>\r
5174                   </clade>\r
5175                   <clade>\r
5176                     <name>WNT1_BOMMO/57-392</name>\r
5177                     <branch_length>0.0606</branch_length>\r
5178                     <color>\r
5179                       <red>0</red>\r
5180                       <green>173</green>\r
5181                       <blue>193</blue>\r
5182                     </color>\r
5183                     <taxonomy>\r
5184                       <id provider="uniprot">7091</id>\r
5185                       <code>BOMMO</code>\r
5186                       <scientific_name>Bombyx mori</scientific_name>\r
5187                       <common_name>Silk moth</common_name>\r
5188                       <rank>species</rank>\r
5189                     </taxonomy>\r
5190                     <sequence type="protein">\r
5191                       <accession source="uniprot">P49340</accession>\r
5192                       <name>Protein Wnt-1</name>\r
5193                       <gene_name>WNT-1</gene_name>\r
5194                       <mol_seq is_aligned="true">VHATL------RRKQRRLARENPG--------VLAAVAK-AQYAFAECQHQFKYRRWNCSTRNFLR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHSLARACREASI-ESCTCDYSHRPRAA---------QNPVGGRANVRV-----------------------------------------------------------------------WKWGGCSDNI-GFGFRFSREFVDTGE--------RGKTLREK--MNLHNNEAGRRHVQTEMKQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRSVGDSLKDRFDG-ASRVMLSKADVETPAQR-NEAAPHR---------------------------------------------------------VPRKDRYR-FQL-------------RPHNPDHK----SP----------GVKDLVYLESSPGFCEKNPRL-GIPGTHGRAC-------------NDT-SI---------GVDG-CDLMC--CGRGYKTNTMFVVE-RCNCT-FH-----WCCEVKCKLCRTEKVVHTCL</mol_seq>\r
5195                       <annotation ref="GO:0005578">\r
5196                         <desc>proteinaceous extracellular matrix</desc>\r
5197                       </annotation>\r
5198                       <annotation ref="GO:0007275">\r
5199                         <desc>multicellular organismal development</desc>\r
5200                       </annotation>\r
5201                       <annotation ref="GO:0016055">\r
5202                         <desc>Wnt signaling pathway</desc>\r
5203                       </annotation>\r
5204                       <cross_references>\r
5205                         <accession source="CTD">692745</accession>\r
5206                         <accession source="KEGG">bmor:692745</accession>\r
5207                       </cross_references>\r
5208                     </sequence>\r
5209                   </clade>\r
5210                 </clade>\r
5211                 <clade>\r
5212                   <name>Q9GRA6_GRYBI/62-394</name>\r
5213                   <branch_length>0.07433</branch_length>\r
5214                   <color>\r
5215                     <red>0</red>\r
5216                     <green>173</green>\r
5217                     <blue>193</blue>\r
5218                   </color>\r
5219                   <taxonomy>\r
5220                     <id provider="uniprot">6999</id>\r
5221                     <code>GRYBI</code>\r
5222                     <scientific_name>Gryllus bimaculatus</scientific_name>\r
5223                     <common_name>Two-spotted cricket</common_name>\r
5224                     <rank>species</rank>\r
5225                   </taxonomy>\r
5226                   <sequence type="protein">\r
5227                     <accession source="uniprot">Q9GRA6</accession>\r
5228                     <name>Protein Wnt</name>\r
5229                     <gene_name>wg</gene_name>\r
5230                     <mol_seq is_aligned="true">VHATL------RRKQRRLVRDHPG--------VLLAVVKGANQAIGECQFQFRNRRWNCSTKNFFR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHAIARACAEGSI-QSCTCDYRHAGRVA---------GGRGGGGGGGKKPD---------------------------------------------------------------------WEWGGCSDNI-EYGFKFSRDFVDTGE--------RGRTLREK--MNLHNNEAGRLHVREEMRKECKCH---GMSGSCTVKT--------------------CWM-RLPHFRVVGDNLKDRFDG-ASRVLVGNAGSPRGPGA-GKGKG-------------------------------------------------------------NRYNFQ-LQ---------------PYDAQHK----PP----------GRKDLVYLDQSPNFCERNPRQ-GIQGTHGREC-------------NET-SL---------GLDG-CDLMC--CGRGHRSQEVMLVE-RCHCT-FH-----WCCEVKCKTCHVRKTIHTCQ</mol_seq>\r
5231                     <annotation ref="GO:0005578">\r
5232                       <desc>proteinaceous extracellular matrix</desc>\r
5233                     </annotation>\r
5234                     <annotation ref="GO:0007275">\r
5235                       <desc>multicellular organismal development</desc>\r
5236                     </annotation>\r
5237                     <annotation ref="GO:0016055">\r
5238                       <desc>Wnt signaling pathway</desc>\r
5239                     </annotation>\r
5240                   </sequence>\r
5241                 </clade>\r
5242               </clade>\r
5243               <clade>\r
5244                 <branch_length>0.0145</branch_length>\r
5245                 <confidence type="bootstrap">81</confidence>\r
5246                 <color>\r
5247                   <red>0</red>\r
5248                   <green>132</green>\r
5249                   <blue>132</blue>\r
5250                 </color>\r
5251                 <taxonomy>\r
5252                   <id provider="uniprot">6340</id>\r
5253                   <scientific_name>Annelida</scientific_name>\r
5254                   <rank>phylum</rank>\r
5255                 </taxonomy>\r
5256                 <clade>\r
5257                   <name>Q2QJF8_9ANNE/61-379</name>\r
5258                   <branch_length>0.14789</branch_length>\r
5259                   <color>\r
5260                     <red>0</red>\r
5261                     <green>132</green>\r
5262                     <blue>132</blue>\r
5263                   </color>\r
5264                   <taxonomy>\r
5265                     <id provider="uniprot">283909</id>\r
5266                     <code>9ANNE</code>\r
5267                     <scientific_name>Capitella teleta</scientific_name>\r
5268                     <rank>phylum</rank>\r
5269                   </taxonomy>\r
5270                   <sequence type="protein">\r
5271                     <accession source="uniprot">Q2QJF8</accession>\r
5272                     <name>Protein Wnt</name>\r
5273                     <gene_name>wg</gene_name>\r
5274                     <mol_seq is_aligned="true">INPSLQPLT---RKQRRLVTRNPG--------TSIAIAKAARMAVDECQRQFSTRRWNCPVYDASH------------------------------GSSIFGK-VVRKG--IRECAFIYAIMSAALAHSIARSCAEGSI-YTCTCGRHSRRLAN---------SVQPRD-----------------------------------------------------------------------------WEWGGCSDNA-EFGRKFSHDFIDVAE--------KGRDLKCL--MNLHNSEAGRTQVSSEMSKECKCH---GMSGSCTVKT--------------------CWM-KLPMFGRVGKVVKDRFDG-ASQVEQGNGAINRSKNR-FN--------------------------------------------------------------------LI-P-----------------INTNHK----PP----------EPKDLVYFERSPTFCTKDPSI-GHTGTHGRPC-------------NAS-SI---------GVEG-CDLLC--CGRGYRSELYTARE-RCNCI-FH-----WCCKVTCDTCTKTKVRHICL</mol_seq>\r
5275                     <annotation ref="GO:0005578">\r
5276                       <desc>proteinaceous extracellular matrix</desc>\r
5277                     </annotation>\r
5278                     <annotation ref="GO:0007275">\r
5279                       <desc>multicellular organismal development</desc>\r
5280                     </annotation>\r
5281                     <annotation ref="GO:0016055">\r
5282                       <desc>Wnt signaling pathway</desc>\r
5283                     </annotation>\r
5284                   </sequence>\r
5285                 </clade>\r
5286                 <clade>\r
5287                   <name>Q8MPL8_PLADU/57-388</name>\r
5288                   <branch_length>0.14646</branch_length>\r
5289                   <color>\r
5290                     <red>0</red>\r
5291                     <green>132</green>\r
5292                     <blue>132</blue>\r
5293                   </color>\r
5294                   <taxonomy>\r
5295                     <id provider="uniprot">6359</id>\r
5296                     <code>PLADU</code>\r
5297                     <scientific_name>Platynereis dumerilii</scientific_name>\r
5298                     <common_name>Dumeril&apos;s clam worm</common_name>\r
5299                     <rank>species</rank>\r
5300                   </taxonomy>\r
5301                   <sequence type="protein">\r
5302                     <accession source="uniprot">Q8MPL8</accession>\r
5303                     <name>Protein Wnt</name>\r
5304                     <gene_name>wnt1</gene_name>\r
5305                     <mol_seq is_aligned="true">INPSLQPLT---RKQRRVVTRNPG--------TIVAVAKGARVAIHECQFQFRNRRWNCPTTEDGR------------------------------GGSIFGDIFKAAG--TRETAFIYAVTAAGVTHSVARACSEGSI-FTCSCGRRR--------------------RIDVTSSLPTSAAS---------------------------------------------------------IPPAATWEWGGCSDNI-EFGQRFSREFVDLVE--------KGRDLRYM--MNLHNNQAGRIHVVSEQHQECKCH---GMSGSCTVKT--------------------CWM-RLAPFRQTGARLKDRFDG-APRVYQGNSGNSRNRNRLQKF-----------------------------------------------------------------NLLPV-------------------NPNHK----SP----------GPQDLVYFEESPTFCDENRTL-GLQGTTGRQC-------------NVS-SI---------GVDG-CDLMC--CGRGWVEETYLSKE-RCNCT-FH-----WCGQVTCHICNRTRVRHLCL</mol_seq>\r
5306                     <annotation ref="GO:0005578">\r
5307                       <desc>proteinaceous extracellular matrix</desc>\r
5308                     </annotation>\r
5309                     <annotation ref="GO:0007275">\r
5310                       <desc>multicellular organismal development</desc>\r
5311                     </annotation>\r
5312                     <annotation ref="GO:0016055">\r
5313                       <desc>Wnt signaling pathway</desc>\r
5314                     </annotation>\r
5315                   </sequence>\r
5316                 </clade>\r
5317               </clade>\r
5318             </clade>\r
5319             <clade>\r
5320               <name>Q8T396_CUPSA/63-374</name>\r
5321               <branch_length>0.11699</branch_length>\r
5322               <color>\r
5323                 <red>0</red>\r
5324                 <green>173</green>\r
5325                 <blue>193</blue>\r
5326               </color>\r
5327               <taxonomy>\r
5328                 <id provider="uniprot">6928</id>\r
5329                 <code>CUPSA</code>\r
5330                 <scientific_name>Cupiennius salei</scientific_name>\r
5331                 <common_name>Wandering spider</common_name>\r
5332                 <rank>species</rank>\r
5333               </taxonomy>\r
5334               <sequence type="protein">\r
5335                 <accession source="uniprot">Q8T396</accession>\r
5336                 <name>Protein Wnt</name>\r
5337                 <gene_name>wg</gene_name>\r
5338                 <mol_seq is_aligned="true">PAPHLPLRK----KQRRLVRDNPG--------AMQAIGRGVKVAISECKYQFKKRRWNCPTADHAR------------------------------GKNIFGK-IVQRG--CRETAFLYAITSAGVTHSLSRACREGLV-STCNCDYRR--------------------RGPSGLH----------------------------------------------------------------------WEWGGCSDNI-DFGAKFSRQFVDASE--------RGKDLRYI--MNLHNNEAGRAHVIGGMRRQCKCH---GMSGSCTVQT--------------------CWM-QLSPFRTIGDGLKDRFDG-ASRVLVTNRGNVRRRAL-L---------------------------------------------------------------------KP-------------------YHPEHK----PP----------SKKDLVYFENSPDFCYADPSL-GHSATLGRTC-------------NVS-SL---------GVDG-CDLMC--CGRGYKSENREEVS-RCNCT-FH-----WCCQVECKTCKTKRLVHECL</mol_seq>\r
5339                 <annotation ref="GO:0005578">\r
5340                   <desc>proteinaceous extracellular matrix</desc>\r
5341                 </annotation>\r
5342                 <annotation ref="GO:0007275">\r
5343                   <desc>multicellular organismal development</desc>\r
5344                 </annotation>\r
5345                 <annotation ref="GO:0016055">\r
5346                   <desc>Wnt signaling pathway</desc>\r
5347                 </annotation>\r
5348               </sequence>\r
5349             </clade>\r
5350           </clade>\r
5351           <clade>\r
5352             <branch_length>0.06569</branch_length>\r
5353             <confidence type="bootstrap">100</confidence>\r
5354             <color>\r
5355               <red>20</red>\r
5356               <green>71</green>\r
5357               <blue>142</blue>\r
5358             </color>\r
5359             <taxonomy>\r
5360               <id provider="uniprot">117571</id>\r
5361               <scientific_name>Euteleostomi</scientific_name>\r
5362             </taxonomy>\r
5363             <clade>\r
5364               <branch_length>0.00506</branch_length>\r
5365               <confidence type="bootstrap">55</confidence>\r
5366               <color>\r
5367                 <red>20</red>\r
5368                 <green>71</green>\r
5369                 <blue>142</blue>\r
5370               </color>\r
5371               <clade>\r
5372                 <name>Q3UR96_MOUSE/57-370</name>\r
5373                 <branch_length>0.06041</branch_length>\r
5374                 <color>\r
5375                   <red>20</red>\r
5376                   <green>71</green>\r
5377                   <blue>142</blue>\r
5378                 </color>\r
5379                 <taxonomy>\r
5380                   <id provider="uniprot">10090</id>\r
5381                   <code>MOUSE</code>\r
5382                   <scientific_name>Mus musculus</scientific_name>\r
5383                   <common_name>Mouse</common_name>\r
5384                   <rank>species</rank>\r
5385                 </taxonomy>\r
5386                 <sequence type="protein">\r
5387                   <accession source="uniprot">Q3UR96</accession>\r
5388                   <name>Protein Wnt</name>\r
5389                   <gene_name>Wnt1</gene_name>\r
5390                   <mol_seq is_aligned="true">LEPSLQLLS---RKQRRLIRQNPG--------ILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP---------------------------------HLFGK-IVNRG--CRETAFIFAITSAGVTHSVARSCSEGSI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-DFGRLFGREFVDSGE--------KGRDLRFL--MNLHNNEAGRTTVFSEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPTLRAVGDVLRDRFDG-ASRVLYGNRGSNRAS---RAE-----------------------------------------------------------------LLRL-E----------------PEDPAHK----PP----------SPHDLVYFEKSPNFCTYSGRL-GTAGTAGRAC-------------NSS-SP---------ALDG-CELLC--CGRGHRTRTQRVTE-RCNCT-FH-----WCCHVSCRNCTHTRVLHECL</mol_seq>\r
5391                   <annotation ref="GO:0001658">\r
5392                     <desc>branching involved in ureteric bud morphogenesis</desc>\r
5393                   </annotation>\r
5394                   <annotation ref="GO:0001934">\r
5395                     <desc>positive regulation of protein phosphorylation</desc>\r
5396                   </annotation>\r
5397                   <annotation ref="GO:0005102">\r
5398                     <desc>receptor binding</desc>\r
5399                   </annotation>\r
5400                   <annotation ref="GO:0005109">\r
5401                     <desc>frizzled binding</desc>\r
5402                   </annotation>\r
5403                   <annotation ref="GO:0005515">\r
5404                     <desc>protein binding</desc>\r
5405                   </annotation>\r
5406                   <annotation ref="GO:0005578">\r
5407                     <desc>proteinaceous extracellular matrix</desc>\r
5408                   </annotation>\r
5409                   <annotation ref="GO:0005615">\r
5410                     <desc>extracellular space</desc>\r
5411                   </annotation>\r
5412                   <annotation ref="GO:0005737">\r
5413                     <desc>cytoplasm</desc>\r
5414                   </annotation>\r
5415                   <annotation ref="GO:0007165">\r
5416                     <desc>signal transduction</desc>\r
5417                   </annotation>\r
5418                   <annotation ref="GO:0007267">\r
5419                     <desc>cell-cell signaling</desc>\r
5420                   </annotation>\r
5421                   <annotation ref="GO:0007520">\r
5422                     <desc>myoblast fusion</desc>\r
5423                   </annotation>\r
5424                   <annotation ref="GO:0008284">\r
5425                     <desc>positive regulation of cell proliferation</desc>\r
5426                   </annotation>\r
5427                   <annotation ref="GO:0009611">\r
5428                     <desc>response to wounding</desc>\r
5429                   </annotation>\r
5430                   <annotation ref="GO:0009887">\r
5431                     <desc>organ morphogenesis</desc>\r
5432                   </annotation>\r
5433                   <annotation ref="GO:0009986">\r
5434                     <desc>cell surface</desc>\r
5435                   </annotation>\r
5436                   <annotation ref="GO:0010592">\r
5437                     <desc>positive regulation of lamellipodium assembly</desc>\r
5438                   </annotation>\r
5439                   <annotation ref="GO:0010812">\r
5440                     <desc>negative regulation of cell-substrate adhesion</desc>\r
5441                   </annotation>\r
5442                   <annotation ref="GO:0014902">\r
5443                     <desc>myotube differentiation</desc>\r
5444                   </annotation>\r
5445                   <annotation ref="GO:0016055">\r
5446                     <desc>Wnt signaling pathway</desc>\r
5447                   </annotation>\r
5448                   <annotation ref="GO:0021527">\r
5449                     <desc>spinal cord association neuron differentiation</desc>\r
5450                   </annotation>\r
5451                   <annotation ref="GO:0021536">\r
5452                     <desc>diencephalon development</desc>\r
5453                   </annotation>\r
5454                   <annotation ref="GO:0021797">\r
5455                     <desc>forebrain anterior/posterior pattern specification</desc>\r
5456                   </annotation>\r
5457                   <annotation ref="GO:0022004">\r
5458                     <desc>midbrain-hindbrain boundary maturation during brain development</desc>\r
5459                   </annotation>\r
5460                   <annotation ref="GO:0022037">\r
5461                     <desc>metencephalon development</desc>\r
5462                   </annotation>\r
5463                   <annotation ref="GO:0022408">\r
5464                     <desc>negative regulation of cell-cell adhesion</desc>\r
5465                   </annotation>\r
5466                   <annotation ref="GO:0030509">\r
5467                     <desc>BMP signaling pathway</desc>\r
5468                   </annotation>\r
5469                   <annotation ref="GO:0030512">\r
5470                     <desc>negative regulation of transforming growth factor beta receptor signaling pathway</desc>\r
5471                   </annotation>\r
5472                   <annotation ref="GO:0030514">\r
5473                     <desc>negative regulation of BMP signaling pathway</desc>\r
5474                   </annotation>\r
5475                   <annotation ref="GO:0030579">\r
5476                     <desc>ubiquitin-dependent SMAD protein catabolic process</desc>\r
5477                   </annotation>\r
5478                   <annotation ref="GO:0030901">\r
5479                     <desc>midbrain development</desc>\r
5480                   </annotation>\r
5481                   <annotation ref="GO:0030917">\r
5482                     <desc>midbrain-hindbrain boundary development</desc>\r
5483                   </annotation>\r
5484                   <annotation ref="GO:0031100">\r
5485                     <desc>organ regeneration</desc>\r
5486                   </annotation>\r
5487                   <annotation ref="GO:0033077">\r
5488                     <desc>T cell differentiation in thymus</desc>\r
5489                   </annotation>\r
5490                   <annotation ref="GO:0042472">\r
5491                     <desc>inner ear morphogenesis</desc>\r
5492                   </annotation>\r
5493                   <annotation ref="GO:0042770">\r
5494                     <desc>signal transduction in response to DNA damage</desc>\r
5495                   </annotation>\r
5496                   <annotation ref="GO:0043568">\r
5497                     <desc>positive regulation of insulin-like growth factor receptor signaling pathway</desc>\r
5498                   </annotation>\r
5499                   <annotation ref="GO:0044212">\r
5500                     <desc>transcription regulatory region DNA binding</desc>\r
5501                   </annotation>\r
5502                   <annotation ref="GO:0044336">\r
5503                     <desc>canonical Wnt signaling pathway involved in negative regulation of apoptotic process</desc>\r
5504                   </annotation>\r
5505                   <annotation ref="GO:0045599">\r
5506                     <desc>negative regulation of fat cell differentiation</desc>\r
5507                   </annotation>\r
5508                   <annotation ref="GO:0045747">\r
5509                     <desc>positive regulation of Notch signaling pathway</desc>\r
5510                   </annotation>\r
5511                   <annotation ref="GO:0045893">\r
5512                     <desc>positive regulation of transcription, DNA-templated</desc>\r
5513                   </annotation>\r
5514                   <annotation ref="GO:0045944">\r
5515                     <desc>positive regulation of transcription from RNA polymerase II promoter</desc>\r
5516                   </annotation>\r
5517                   <annotation ref="GO:0048146">\r
5518                     <desc>positive regulation of fibroblast proliferation</desc>\r
5519                   </annotation>\r
5520                   <annotation ref="GO:0048663">\r
5521                     <desc>neuron fate commitment</desc>\r
5522                   </annotation>\r
5523                   <annotation ref="GO:0048664">\r
5524                     <desc>neuron fate determination</desc>\r
5525                   </annotation>\r
5526                   <annotation ref="GO:0060070">\r
5527                     <desc>canonical Wnt signaling pathway</desc>\r
5528                   </annotation>\r
5529                   <annotation ref="GO:0060348">\r
5530                     <desc>bone development</desc>\r
5531                   </annotation>\r
5532                   <annotation ref="GO:0061184">\r
5533                     <desc>positive regulation of dermatome development</desc>\r
5534                   </annotation>\r
5535                   <annotation ref="GO:0070365">\r
5536                     <desc>hepatocyte differentiation</desc>\r
5537                   </annotation>\r
5538                   <annotation ref="GO:0071375">\r
5539                     <desc>cellular response to peptide hormone stimulus</desc>\r
5540                   </annotation>\r
5541                   <annotation ref="GO:0071425">\r
5542                     <desc>hematopoietic stem cell proliferation</desc>\r
5543                   </annotation>\r
5544                   <annotation ref="GO:0090344">\r
5545                     <desc>negative regulation of cell aging</desc>\r
5546                   </annotation>\r
5547                   <annotation ref="GO:2000059">\r
5548                     <desc>negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process</desc>\r
5549                   </annotation>\r
5550                   <cross_references>\r
5551                     <accession source="CTD">7471</accession>\r
5552                     <accession source="KEGG">mmu:22408</accession>\r
5553                     <accession source="NextBio">302801</accession>\r
5554                   </cross_references>\r
5555                 </sequence>\r
5556               </clade>\r
5557               <clade>\r
5558                 <name>Q4TCL8_TETNG/22-336</name>\r
5559                 <branch_length>0.05449</branch_length>\r
5560                 <color>\r
5561                   <red>20</red>\r
5562                   <green>71</green>\r
5563                   <blue>142</blue>\r
5564                 </color>\r
5565                 <taxonomy>\r
5566                   <id provider="uniprot">99883</id>\r
5567                   <code>TETNG</code>\r
5568                   <scientific_name>Tetraodon nigroviridis</scientific_name>\r
5569                   <common_name>Spotted green pufferfish</common_name>\r
5570                   <synonym>Chelonodon nigroviridis</synonym>\r
5571                   <rank>species</rank>\r
5572                 </taxonomy>\r
5573                 <sequence type="protein">\r
5574                   <accession source="uniprot">Q4TCL8</accession>\r
5575                   <name>Protein Wnt</name>\r
5576                   <mol_seq is_aligned="true">LDPSLALLS---RRQRRLIRQNPG--------ILHAIAAGLHAAIKECKWQFRNRRWNCPTTHSP---------------------------------AVFGK-IVNRG--CRETAFVFAITSAGVTHAVARSCSEGAI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNV-EFGRMFTREFVDSSE--------RGRDLRYL--TNLHNNEAGRMTVSTEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPSFRTVGDFLKDRFDG-ASRVVYANKGSNRASH--KAN-----------------------------------------------------------------PRHL-E----------------PENPAHK----SP----------SSMDLVYFEKSPNFCSYSGKT-GTLGTSGRMC-------------NST-SP---------GLDG-CELLC--CGRGFKTRTETVTE-RCHCT-FH-----WCCHVSCLNCTSTRTLHQCV</mol_seq>\r
5577                   <annotation ref="GO:0005578">\r
5578                     <desc>proteinaceous extracellular matrix</desc>\r
5579                   </annotation>\r
5580                   <annotation ref="GO:0016055">\r
5581                     <desc>Wnt signaling pathway</desc>\r
5582                   </annotation>\r
5583                   <annotation ref="GO:0021587">\r
5584                     <desc>cerebellum morphogenesis</desc>\r
5585                   </annotation>\r
5586                   <annotation ref="GO:0021592">\r
5587                     <desc>fourth ventricle development</desc>\r
5588                   </annotation>\r
5589                   <annotation ref="GO:0030917">\r
5590                     <desc>midbrain-hindbrain boundary development</desc>\r
5591                   </annotation>\r
5592                   <annotation ref="GO:0035284">\r
5593                     <desc>brain segmentation</desc>\r
5594                   </annotation>\r
5595                 </sequence>\r
5596               </clade>\r
5597             </clade>\r
5598             <clade>\r
5599               <name>WNT1_XENLA/58-371</name>\r
5600               <branch_length>0.0706</branch_length>\r
5601               <color>\r
5602                 <red>20</red>\r
5603                 <green>71</green>\r
5604                 <blue>142</blue>\r
5605               </color>\r
5606               <taxonomy>\r
5607                 <id provider="uniprot">8355</id>\r
5608                 <code>XENLA</code>\r
5609                 <scientific_name>Xenopus laevis</scientific_name>\r
5610                 <common_name>African clawed frog</common_name>\r
5611                 <rank>species</rank>\r
5612               </taxonomy>\r
5613               <sequence type="protein">\r
5614                 <symbol>XWnt-1</symbol>\r
5615                 <accession source="uniprot">P10108</accession>\r
5616                 <name>Protein Wnt-1</name>\r
5617                 <gene_name>wnt1</gene_name>\r
5618                 <mol_seq is_aligned="true">LDPSLQLLS----RQKRLIRQNPG--------ILQSITRGLHSAIRECKWHFRNRRWNCPTGTGN---------------------------------QVFGK-IINRG--CRETAFVFAITSAGVTHSVARSCSEGSI-ESCSCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-EFGRFIGREFVDSSE--------RGRDLKYL--VNLHNNQAGRLTVLTEMRQECKCH---GMSGSCSLRT--------------------CWM-RLPPFRSVGDALKDRFDG-ASKVTYSNNGSNRWGS--RSD-----------------------------------------------------------------PPHL-E----------------PENPTHA----LP----------SSQDLVYFEKSPNFCSPSEKN-GTPGTTGRIC-------------NST-SL---------GLDG-CELLC--CGRGYRSLAEKVTE-RCHCT-FN-----WCCHVTCLNCTSSQIVHECL</mol_seq>\r
5619                 <annotation ref="GO:0005578">\r
5620                   <desc>proteinaceous extracellular matrix</desc>\r
5621                 </annotation>\r
5622                 <annotation ref="GO:0014036">\r
5623                   <desc>neural crest cell fate specification</desc>\r
5624                 </annotation>\r
5625                 <annotation ref="GO:0016055">\r
5626                   <desc>Wnt signaling pathway</desc>\r
5627                 </annotation>\r
5628                 <annotation ref="GO:0021797">\r
5629                   <desc>forebrain anterior/posterior pattern specification</desc>\r
5630                 </annotation>\r
5631                 <annotation ref="GO:0045892">\r
5632                   <desc>negative regulation of transcription, DNA-templated</desc>\r
5633                 </annotation>\r
5634                 <cross_references>\r
5635                   <accession source="CTD">7471</accession>\r
5636                   <accession source="KEGG">xla:373578</accession>\r
5637                 </cross_references>\r
5638               </sequence>\r
5639             </clade>\r
5640           </clade>\r
5641         </clade>\r
5642         <clade>\r
5643           <name>O61699_BRAFL/59-377</name>\r
5644           <branch_length>0.15398</branch_length>\r
5645           <color>\r
5646             <red>20</red>\r
5647             <green>71</green>\r
5648             <blue>142</blue>\r
5649           </color>\r
5650           <taxonomy>\r
5651             <id provider="uniprot">7739</id>\r
5652             <code>BRAFL</code>\r
5653             <scientific_name>Branchiostoma floridae</scientific_name>\r
5654             <common_name>Florida lancelet</common_name>\r
5655             <synonym>Amphioxus</synonym>\r
5656             <rank>species</rank>\r
5657           </taxonomy>\r
5658           <sequence type="protein">\r
5659             <accession source="uniprot">O61699</accession>\r
5660             <name>Protein Wnt</name>\r
5661             <gene_name>Wnt1</gene_name>\r
5662             <mol_seq is_aligned="true">LDPKKHPLN---KKQRRLVRRNPG-------DAGEHRDRRPMLAIKECHHQFSKWRWNCPVNTSDH------------------------------VNSVFGN-ILLRG--CTQTAFIYAVMSAAVAHEVGRNCAEGTI-ETCSCDYRS--------------------KGPAGED----------------------------------------------------------------------WEWGGCSDNV-EFGKQFAKQFVDAGE-------KTKDSVRYL--VNMHNNEAGRVAVAENLRRECKCH---GMSGSCTLKT--------------------CWM-RLPNFRDVGDSLKEKFDG-ASKVAFPDIGNNRGSRAKVT-------------------------------------------------------------------GLV-P-----------------KNSRHK----FP----------TDNDLVYHERSPNFCRNNPRL-GFEGTRGREC-------------NVT-SR---------GLDG-CDLLC--CGRGYATRQEVTKE-RCNCT-FQ-----WCCQVKCEECVRTKTIHTCL</mol_seq>\r
5663             <annotation ref="GO:0005578">\r
5664               <desc>proteinaceous extracellular matrix</desc>\r
5665             </annotation>\r
5666             <annotation ref="GO:0007275">\r
5667               <desc>multicellular organismal development</desc>\r
5668             </annotation>\r
5669             <annotation ref="GO:0016055">\r
5670               <desc>Wnt signaling pathway</desc>\r
5671             </annotation>\r
5672           </sequence>\r
5673         </clade>\r
5674       </clade>\r
5675       <clade>\r
5676         <name>Q5J2D4_NEMVE/46-364</name>\r
5677         <branch_length>0.17152</branch_length>\r
5678         <color>\r
5679           <red>20</red>\r
5680           <green>132</green>\r
5681           <blue>81</blue>\r
5682         </color>\r
5683         <taxonomy>\r
5684           <id provider="uniprot">45351</id>\r
5685           <code>NEMVE</code>\r
5686           <scientific_name>Nematostella vectensis</scientific_name>\r
5687           <common_name>Starlet sea anemone</common_name>\r
5688           <rank>species</rank>\r
5689         </taxonomy>\r
5690         <sequence type="protein">\r
5691           <accession source="uniprot">Q5J2D4</accession>\r
5692           <name>Protein Wnt</name>\r
5693           <mol_seq is_aligned="true">PPNQIRALT---QKQIRISRRYPE--------LIQYIAGGARTAIHECQHQFRNRKWNCSAHSPE---------------------------------NVFGK-ILKRA--CRETAFTYAITAAGVSHAIARACGEGKL-SACSCDQRY--------------------RGVSKQG----------------------------------------------------------------------WQWGGCSDNI-HFADNFSKRFVDAQE--------KGRDFRAQ--INLHNNEAGRAAVRNNMMLECKCH---GLSEACTVKT--------------------CWK-RLPDFRLVGDDLKAKFDD-ASMVEYQQNNNNRNSNRNRN-------------------------------------------------------------------EDP-A-----------------LFIPSKPYLRRP----------TVYDLGYYEHSPNFCERNPSA-GSLGTQGREC-------------NTT-SM---------GTDG-CELMC--CGRGFTTSSQERVE-NCNCRVFL-----GGCEVKCQKCKHEGSLSNCL</mol_seq>\r
5694           <annotation ref="GO:0005578">\r
5695             <desc>proteinaceous extracellular matrix</desc>\r
5696           </annotation>\r
5697           <annotation ref="GO:0007275">\r
5698             <desc>multicellular organismal development</desc>\r
5699           </annotation>\r
5700           <annotation ref="GO:0016055">\r
5701             <desc>Wnt signaling pathway</desc>\r
5702           </annotation>\r
5703         </sequence>\r
5704       </clade>\r
5705     </clade>\r
5706   </clade>\r
5707 </phylogeny>\r
5708 </phyloxml>