1 <?xml version="1.0" encoding="UTF-8"?>
\r
2 <phyloxml xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.phyloxml.org http://www.phyloxml.org/1.10/phyloxml.xsd" xmlns="http://www.phyloxml.org">
\r
3 <phylogeny rooted="true" rerootable="false">
\r
6 <id provider="uniprot">33208</id>
\r
7 <scientific_name>Metazoa</scientific_name>
\r
11 <branch_length>0.012195</branch_length>
\r
12 <confidence type="bootstrap">99</confidence>
\r
14 <branch_length>0.00662</branch_length>
\r
15 <confidence type="bootstrap">28</confidence>
\r
17 <branch_length>0.00344</branch_length>
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18 <confidence type="bootstrap">6</confidence>
\r
20 <branch_length>0.0022</branch_length>
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21 <confidence type="bootstrap">1</confidence>
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23 <branch_length>0.00148</branch_length>
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24 <confidence type="bootstrap">0</confidence>
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26 <branch_length>0.00396</branch_length>
\r
27 <confidence type="bootstrap">5</confidence>
\r
29 <branch_length>0.00258</branch_length>
\r
30 <confidence type="bootstrap">15</confidence>
\r
32 <branch_length>0.01323</branch_length>
\r
33 <confidence type="bootstrap">61</confidence>
\r
35 <branch_length>0.00504</branch_length>
\r
36 <confidence type="bootstrap">46</confidence>
\r
38 <branch_length>0.01441</branch_length>
\r
39 <confidence type="bootstrap">65</confidence>
\r
41 <branch_length>0.02347</branch_length>
\r
42 <confidence type="bootstrap">100</confidence>
\r
44 <branch_length>0.01855</branch_length>
\r
45 <confidence type="bootstrap">94</confidence>
\r
52 <id provider="uniprot">117571</id>
\r
53 <scientific_name>Euteleostomi</scientific_name>
\r
56 <branch_length>0.01429</branch_length>
\r
57 <confidence type="bootstrap">50</confidence>
\r
64 <branch_length>0.00777</branch_length>
\r
65 <confidence type="bootstrap">57</confidence>
\r
72 <name>WNT2_EULMM/40-349</name>
\r
73 <branch_length>0.06843</branch_length>
\r
80 <id provider="uniprot">30603</id>
\r
82 <scientific_name>Eulemur macaco macaco</scientific_name>
\r
83 <common_name>Black lemur</common_name>
\r
84 <rank>subspecies</rank>
\r
86 <sequence type="protein">
\r
87 <accession source="uniprot">Q2IBG1</accession>
\r
88 <name>Protein Wnt-2</name>
\r
89 <gene_name>WNT2</gene_name>
\r
90 <mol_seq is_aligned="true">MCDNVPGLV---SRQRQLCHRHPD--------VMRAISLGVSEWTAECQHQFRQHRWNCNTLDRD--------------------------------HSLFGR-VLLRS--SRESAFVYAISSAGVVFAITRACSQGEL-KSCSCDPKK--------------------KGTAKDSKG-------------------------------------------------------------------TFDWGGCSDNI-DYGIKFARAFVDAKE-------RKGKDARAL--MNLHNNRAGRKAVKRFLKQECKCH---GVSGSCTLRT--------------------CWL-AMADFRKTGAYLWRKYNG-AIQVVMNQDGTGFTVA----------------------------------------------------------------------------------------------NKRFK----KP----------TKNDLVYFENSPDYCIRDREA-GSLGTAGRVC-------------NLT-SR---------GMDS-CEVMC--CGRGYDTSRVTRMT-KCECK-FH-----WCCAVRCQDCLEALDVHTCK</mol_seq>
\r
91 <annotation ref="GO:0005578">
\r
92 <desc>proteinaceous extracellular matrix</desc>
\r
94 <annotation ref="GO:0007275">
\r
95 <desc>multicellular organismal development</desc>
\r
97 <annotation ref="GO:0016055">
\r
98 <desc>Wnt signaling pathway</desc>
\r
103 <name>Q4SSA4_TETNG/11-320</name>
\r
104 <branch_length>0.06553</branch_length>
\r
111 <id provider="uniprot">99883</id>
\r
113 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
114 <common_name>Spotted green pufferfish</common_name>
\r
115 <synonym>Chelonodon nigroviridis</synonym>
\r
116 <rank>species</rank>
\r
118 <sequence type="protein">
\r
119 <accession source="uniprot">Q4SSA4</accession>
\r
120 <name>Protein Wnt</name>
\r
121 <mol_seq is_aligned="true">ICDNIPGLV---NKQRQLCQGHPD--------LMRSIGEGAKEWIKECQHQFRHHRWNCSTLDRD--------------------------------HTVFGR-VMLRS--SREAAFVYAISSAGVVYAITRACSQGEL-KSCNCDGQK--------------------RGRSSDATG-------------------------------------------------------------------SFDWGGCSDNI-NYGIKFAKAFVDARE-------KMMKDARAL--MNLHNNRCGRMAVKRFMKLECKCH---GVSGSCSLRT--------------------CWL-AMSDFRRTGDYLRKKYNS-AVEVTMNQDGTGFLVA----------------------------------------------------------------------------------------------DKNFK----GN----------TKNELVYVENSPDYCLMDRSA-GSLGTAGRVC-------------NKS-SR---------GTDG-CEIMC--CGRGYDTMRVKRVT-KCECK-FK-----WCCAVECSDCEDIVDVHTCK</mol_seq>
\r
122 <annotation ref="GO:0005578">
\r
123 <desc>proteinaceous extracellular matrix</desc>
\r
125 <annotation ref="GO:0007275">
\r
126 <desc>multicellular organismal development</desc>
\r
128 <annotation ref="GO:0016055">
\r
129 <desc>Wnt signaling pathway</desc>
\r
135 <name>Q8UW39_TAKRU/38-347</name>
\r
136 <branch_length>0.08277</branch_length>
\r
143 <id provider="uniprot">31033</id>
\r
145 <scientific_name>Takifugu rubripes</scientific_name>
\r
146 <common_name>Japanese pufferfish</common_name>
\r
147 <synonym>Fugu rubripes</synonym>
\r
148 <rank>species</rank>
\r
150 <sequence type="protein">
\r
151 <accession source="uniprot">Q8UW39</accession>
\r
152 <name>Protein Wnt</name>
\r
153 <gene_name>WNT2</gene_name>
\r
154 <mol_seq is_aligned="true">MCDNIPGLV---NKQRQLCRQHPK--------VMQAIGSGIKDWISECQHQFRNHRWNCNTTARD--------------------------------HNLFGR-LLLRS--SREVAFIYALSSAGVVYALARACSQGDL-DSCSCDPAK--------------------KGSSRDAKG-------------------------------------------------------------------SFSWGGCSDHV-DHAMRFSQAFVDAKE-------RKERDARAL--MNLHNNRAGRKAVKRFMTLECKCH---GVSGSCSVRT--------------------CWS-AMADFRRTGDHLRKKYNG-AVQVAVNQYGTGFTTA----------------------------------------------------------------------------------------------HAHFK----QP----------GKNDLVYLEDSPDYCVRDQDS-GSLGTGGRLC-------------NRT-SP---------GTDG-CEVMC--CGRGYDTSRVGRTT-KCECK-FH-----WCCAVLCRDCHQQVDVHTCK</mol_seq>
\r
155 <annotation ref="GO:0005578">
\r
156 <desc>proteinaceous extracellular matrix</desc>
\r
158 <annotation ref="GO:0007275">
\r
159 <desc>multicellular organismal development</desc>
\r
161 <annotation ref="GO:0016055">
\r
162 <desc>Wnt signaling pathway</desc>
\r
165 <accession source="CTD">7472</accession>
\r
166 <accession source="KEGG">tru:100137508</accession>
\r
167 </cross_references>
\r
172 <name>WNT2B_MOUSE/69-378</name>
\r
173 <branch_length>0.0898</branch_length>
\r
180 <id provider="uniprot">10090</id>
\r
182 <scientific_name>Mus musculus</scientific_name>
\r
183 <common_name>Mouse</common_name>
\r
184 <rank>species</rank>
\r
186 <sequence type="protein">
\r
187 <accession source="uniprot">O70283</accession>
\r
188 <name>Protein Wnt-2b</name>
\r
189 <gene_name>Wnt2b</gene_name>
\r
190 <mol_seq is_aligned="true">ICDNIPGLV---SRQRQLCQRYPD--------IMRSVGEGAREWIRECQHQFRHHRWNCTTLDRD---------------------------------HTVFGRAMLRS--SREAAFVYAISSAGVVHAITRACSQGEL-SVCSCDPYT--------------------RGRHHDQRG-------------------------------------------------------------------DFDWGGCSDNI-HYGVRFAKAFVDAKE-------KRLKDARAL--MNLHNNRCGRTAVRRFLKLECKCH---GVSGSCTLRT--------------------CWR-ALSDFRRTGDYLRRRYDG-AVQVTATQDGANFTAA----------------------------------------------------------------------------------------------RQGYR----HA----------TRTDLVYFDNSPDYCVLDKAA-GSLGTAGRVC-------------SKT-SK---------GTDG-CEIMC--CGRGYDTTRVTRVT-QCECK-FH-----WCCAVRCKECRNTVDVHTCK</mol_seq>
\r
191 <annotation ref="GO:0002062">
\r
192 <desc>chondrocyte differentiation</desc>
\r
194 <annotation ref="GO:0005102">
\r
195 <desc>receptor binding</desc>
\r
197 <annotation ref="GO:0005109">
\r
198 <desc>frizzled binding</desc>
\r
200 <annotation ref="GO:0005515">
\r
201 <desc>protein binding</desc>
\r
203 <annotation ref="GO:0005578">
\r
204 <desc>proteinaceous extracellular matrix</desc>
\r
206 <annotation ref="GO:0005615">
\r
207 <desc>extracellular space</desc>
\r
209 <annotation ref="GO:0007165">
\r
210 <desc>signal transduction</desc>
\r
212 <annotation ref="GO:0007267">
\r
213 <desc>cell-cell signaling</desc>
\r
215 <annotation ref="GO:0008584">
\r
216 <desc>male gonad development</desc>
\r
218 <annotation ref="GO:0009267">
\r
219 <desc>cellular response to starvation</desc>
\r
221 <annotation ref="GO:0009887">
\r
222 <desc>organ morphogenesis</desc>
\r
224 <annotation ref="GO:0021871">
\r
225 <desc>forebrain regionalization</desc>
\r
227 <annotation ref="GO:0030182">
\r
228 <desc>neuron differentiation</desc>
\r
230 <annotation ref="GO:0060070">
\r
231 <desc>canonical Wnt signaling pathway</desc>
\r
233 <annotation ref="GO:0060492">
\r
234 <desc>lung induction</desc>
\r
236 <annotation ref="GO:0060638">
\r
237 <desc>mesenchymal-epithelial cell signaling</desc>
\r
239 <annotation ref="GO:0071425">
\r
240 <desc>hematopoietic stem cell proliferation</desc>
\r
242 <annotation ref="GO:0090190">
\r
243 <desc>positive regulation of branching involved in ureteric bud morphogenesis</desc>
\r
245 <annotation ref="GO:0090263">
\r
246 <desc>positive regulation of canonical Wnt signaling pathway</desc>
\r
249 <accession source="CTD">7482</accession>
\r
250 <accession source="KEGG">mmu:22414</accession>
\r
251 <accession source="NextBio">302825</accession>
\r
252 </cross_references>
\r
257 <name>A2SVS5_9MOLL/42-350</name>
\r
258 <branch_length>0.10471</branch_length>
\r
265 <id provider="uniprot">6613</id>
\r
267 <scientific_name>Euprymna scolopes</scientific_name>
\r
268 <rank>phylum</rank>
\r
270 <sequence type="protein">
\r
271 <accession source="uniprot">A2SVS5</accession>
\r
272 <name>Protein Wnt</name>
\r
273 <mol_seq is_aligned="true">MCSNIPGLV---GKQKRLCRVHQD--------VMISLRDGVQLGVKECQFQLRSQRWNCSTLDRD--------------------------------ASVFGK-VMLRG--SREAAFVYAISSAAVVHAITRACSKGIL-RNCSCDPSK--------------------IGKGRDKKG-------------------------------------------------------------------HFEWGGCSDNV-QYGSDFSRTFIDARE-------KKVRDARAL--MNLHNNRAGRRAVKRFLKLECRCH---GVSGSCSIRT--------------------CWS-AMMEFRRVGDYLKNKYNG-AVQVMMNQEGTGLIVA----------------------------------------------------------------------------------------------NKDHK----RP----------TRSDL-YFEASPDYCMRNLEI-GSLGTSGRQC-------------NKT-SL---------GTDG-CDIMC--CGRGYDTETVKQTR-KCQCK-FH-----WCCQVKCKECVEYVDVHTCK</mol_seq>
\r
274 <annotation ref="GO:0005578">
\r
275 <desc>proteinaceous extracellular matrix</desc>
\r
277 <annotation ref="GO:0007275">
\r
278 <desc>multicellular organismal development</desc>
\r
280 <annotation ref="GO:0016055">
\r
281 <desc>Wnt signaling pathway</desc>
\r
287 <name>Q75PH4_PARTP/59-367</name>
\r
288 <branch_length>0.15068</branch_length>
\r
295 <id provider="uniprot">114398</id>
\r
297 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
298 <common_name>House spider</common_name>
\r
299 <synonym>Achaearanea tepidariorum</synonym>
\r
300 <rank>species</rank>
\r
302 <sequence type="protein">
\r
303 <accession source="uniprot">Q75PH4</accession>
\r
304 <name>Protein Wnt</name>
\r
305 <gene_name>wnt2</gene_name>
\r
306 <mol_seq is_aligned="true">LCGGIPGLA---RKQREICEQHPD--------ILLSVTKGARIGVSECQAQFRNQRWNCSTLGSG--------------------------------ASVFGSHMLKVD--SRESAFLYAISSAGVTHAIIRSCSRGEI-PNCPCDPLR--------------------RGFGFDPTV------------------------------------------------------------------GGYSWGGCS-HI-SAGVKFARQFIDARE-------DRRKDARAL--MNFHNNRAGRKAVQKKTRLQCKCH---GVSGSCASRT--------------------CWS-AQMEFREVGRLLKRKYEG-AVQVTMSNQMALVS------------------------------------------------------------------------------------------------VDGTK----PY----------TKLDLIYFESSPDFCAINKSL-GTLGTGGRRC-------------DRD-SK---------GVEG-CAILC--CGKGYDTRRELFAE-KCSCK-FN-----WCCKVKCKVCREWKDVYTCK</mol_seq>
\r
307 <annotation ref="GO:0005578">
\r
308 <desc>proteinaceous extracellular matrix</desc>
\r
310 <annotation ref="GO:0007275">
\r
311 <desc>multicellular organismal development</desc>
\r
313 <annotation ref="GO:0016055">
\r
314 <desc>Wnt signaling pathway</desc>
\r
320 <name>Q5IHW2_NEMVE/41-346</name>
\r
321 <branch_length>0.14196</branch_length>
\r
328 <id provider="uniprot">45351</id>
\r
330 <scientific_name>Nematostella vectensis</scientific_name>
\r
331 <common_name>Starlet sea anemone</common_name>
\r
332 <rank>species</rank>
\r
334 <sequence type="protein">
\r
335 <accession source="uniprot">Q5IHW2</accession>
\r
336 <name>Protein Wnt</name>
\r
337 <gene_name>Wnt2</gene_name>
\r
338 <mol_seq is_aligned="true">MCNSITGLI---SIQRQMCLDNPD--------VMVSIGKGAKLGVEECQHQFRDQRWNCSTVNGD--------------------------------ATVFGK-VMRRA--SRETAFVYAISSAGVVHEVTRSCSLGEL-KDCSCRNK---------------------KGRSRKG----------------------------------------------------------------------FEWGGCSDNI-QYGLNFAKAFVDSRE--------VEKDARAL--MNLHNNHVGRRVVKTNMSLDCKCH---GVSGSCSVRT--------------------CWK-SISSFRIVGQHLREKYTT-AVQVTVGQSGGELTNA----------------------------------------------------------------------------------------------EVSYK----KP----------SRDDLVYLEDSPNYCMVDSNT-GSLGTSGREC-------------NGS-AS---------DTTGACSLLC--CGRGFNTIQIEEEY-KCHCK-FH-----WCCYVKCQTCRRTVDKHICK</mol_seq>
\r
339 <annotation ref="GO:0005578">
\r
340 <desc>proteinaceous extracellular matrix</desc>
\r
342 <annotation ref="GO:0007275">
\r
343 <desc>multicellular organismal development</desc>
\r
345 <annotation ref="GO:0016055">
\r
346 <desc>Wnt signaling pathway</desc>
\r
352 <name>Q4H308_CIOIN/51-362</name>
\r
353 <branch_length>0.18192</branch_length>
\r
360 <id provider="uniprot">7719</id>
\r
362 <scientific_name>Ciona intestinalis</scientific_name>
\r
363 <common_name>Transparent sea squirt</common_name>
\r
364 <synonym>Ascidia intestinalis</synonym>
\r
365 <rank>species</rank>
\r
367 <sequence type="protein">
\r
368 <accession source="uniprot">Q4H308</accession>
\r
369 <name>Protein Wnt</name>
\r
370 <gene_name>Ci-Orphan Wnt b</gene_name>
\r
371 <mol_seq is_aligned="true">ICLQMPLEP----EQKQYCKNHTK--------IMERIRDGTEMAMKECQYQFRNERWNCSSADES---------------------------------QGFGK-VLKRG--TREAAFVGAITSAAVAHEVTRACSRGEL-TECSCDGQK--------------------RMGSYRDHR------------------------------------------------------------------GRFEWAGCSDDV-QFGMSVAKIFVNTKD-------NALHDARAI--MNVHNNRAGRKTVKSFMKRFCKCH---GATDTCPLRT--------------------CWD-ALDSFRLSGNQLKRKYDG-ASRVTVKQGSRKMTLHTT--------------------------------------------------------------------------------------------VSSHK----SP----------TKRDLVYLEDSPNYCVRNEAT-GSLGTSGREC-------------NLS-SK---------GIDG-CSLLC--CGRGHDTSSVTRTRINCACV-FH-----WCCEVRCTNCTNTYDIYTCK</mol_seq>
\r
372 <annotation ref="GO:0005109">
\r
373 <desc>frizzled binding</desc>
\r
375 <annotation ref="GO:0005578">
\r
376 <desc>proteinaceous extracellular matrix</desc>
\r
378 <annotation ref="GO:0005615">
\r
379 <desc>extracellular space</desc>
\r
381 <annotation ref="GO:0016055">
\r
382 <desc>Wnt signaling pathway</desc>
\r
384 <annotation ref="GO:0030182">
\r
385 <desc>neuron differentiation</desc>
\r
387 <annotation ref="GO:0045165">
\r
388 <desc>cell fate commitment</desc>
\r
391 <accession source="KEGG">cin:778720</accession>
\r
392 </cross_references>
\r
397 <branch_length>0.03087</branch_length>
\r
398 <confidence type="bootstrap">95</confidence>
\r
400 <branch_length>0.00931</branch_length>
\r
401 <confidence type="bootstrap">76</confidence>
\r
403 <branch_length>0.05457</branch_length>
\r
404 <confidence type="bootstrap">100</confidence>
\r
411 <id provider="uniprot">117571</id>
\r
412 <scientific_name>Euteleostomi</scientific_name>
\r
415 <branch_length>0.02373</branch_length>
\r
416 <confidence type="bootstrap">90</confidence>
\r
423 <name>A5WVL3_DANRE/45-356</name>
\r
424 <branch_length>0.085</branch_length>
\r
431 <id provider="uniprot">7955</id>
\r
433 <scientific_name>Danio rerio</scientific_name>
\r
434 <common_name>Zebrafish</common_name>
\r
435 <synonym>Brachydanio rerio</synonym>
\r
436 <rank>species</rank>
\r
438 <sequence type="protein">
\r
439 <accession source="uniprot">A5WVL3</accession>
\r
440 <name>Protein Wnt</name>
\r
441 <gene_name>wnt16</gene_name>
\r
442 <mol_seq is_aligned="true">GCAHLPLSH----KQKELCARKPH--------LLPSVKEGARLGITECQTQFRHERWNCSTRRDP---------------------------------NVFGY-ELTSG--TKETAFIHAVMAAGLVHAVTRSCSAGNM-TECSCDTSL--------------------LGSGSPTE--------------------------------------------------------------------GWHWGGCSDDI-AFGTSFSRRFIDSAAK-----NTSTRGEEALLIMKQHNSEAGRQAVAKTMLTDCRCH---GVSGSCAVKT--------------------CWR-TMAAFERVGAYLKDRYET-SVHVVDRSKRKVRRKD----------------------------------------------------------------------------------------------KEQRH----VP---------ITKDELIFFNKSPNYCLEDRRL-GVTGTRGRKC-------------NRT-SA---------GPDG-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCETMNDMHTCK</mol_seq>
\r
443 <annotation ref="GO:0005109">
\r
444 <desc>frizzled binding</desc>
\r
446 <annotation ref="GO:0005578">
\r
447 <desc>proteinaceous extracellular matrix</desc>
\r
449 <annotation ref="GO:0005615">
\r
450 <desc>extracellular space</desc>
\r
452 <annotation ref="GO:0007219">
\r
453 <desc>Notch signaling pathway</desc>
\r
455 <annotation ref="GO:0016055">
\r
456 <desc>Wnt signaling pathway</desc>
\r
458 <annotation ref="GO:0030182">
\r
459 <desc>neuron differentiation</desc>
\r
461 <annotation ref="GO:0045165">
\r
462 <desc>cell fate commitment</desc>
\r
464 <annotation ref="GO:0060070">
\r
465 <desc>canonical Wnt signaling pathway</desc>
\r
467 <annotation ref="GO:0060218">
\r
468 <desc>hematopoietic stem cell differentiation</desc>
\r
471 <accession source="CTD">51384</accession>
\r
472 <accession source="KEGG">dre:791563</accession>
\r
473 <accession source="NextBio">20930679</accession>
\r
474 </cross_references>
\r
478 <name>A4ZGN9_XENTR/45-376</name>
\r
479 <branch_length>0.13469</branch_length>
\r
486 <id provider="uniprot">8364</id>
\r
488 <scientific_name>Xenopus tropicalis</scientific_name>
\r
489 <common_name>Western clawed frog</common_name>
\r
490 <synonym>Silurana tropicalis</synonym>
\r
491 <rank>species</rank>
\r
493 <sequence type="protein">
\r
494 <accession source="uniprot">A4ZGN9</accession>
\r
495 <name>Protein Wnt</name>
\r
496 <gene_name>wnt16</gene_name>
\r
497 <mol_seq is_aligned="true">GCTNLPLSF----HQKEMCRKKPY--------LLSSIREGARLGIHECRNQFKHERWNCSVSPTISSASSSFSLS-------------FITSSLASAHTIFGY-ELSSG--TKETAFISAVTAAGLVHSVTRACSAGNM-TECSCDTSL--------------------QNGGSASE--------------------------------------------------------------------GWHWGGCSDDL-QYGMWFSRKFLDAPYK-----NSSGRDSDVLNAMHLHNNEAGRQAVTKLMTVDCRCH---GVSGSCAVKT--------------------CWK-SMSSFEKIGNFLKNKYEN-SIQIADRLKRKVRRRE----------------------------------------------------------------------------------------------KNDRK----IP---------IYKGDLVYTNKSPNYCVEDPKL-GISGTHGREC-------------NRT-SE---------GSDS-CNLLC--CGRGYNTHVVRHVE-RCECK-FV-----WCCYVRCRRCESMTDVHTCK</mol_seq>
\r
498 <annotation ref="GO:0005578">
\r
499 <desc>proteinaceous extracellular matrix</desc>
\r
501 <annotation ref="GO:0007219">
\r
502 <desc>Notch signaling pathway</desc>
\r
504 <annotation ref="GO:0016055">
\r
505 <desc>Wnt signaling pathway</desc>
\r
507 <annotation ref="GO:0060218">
\r
508 <desc>hematopoietic stem cell differentiation</desc>
\r
511 <accession source="CTD">51384</accession>
\r
512 <accession source="KEGG">xtr:100125197</accession>
\r
513 </cross_references>
\r
518 <name>Q4T8H0_TETNG/14-319</name>
\r
519 <branch_length>0.11715</branch_length>
\r
526 <id provider="uniprot">99883</id>
\r
528 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
529 <common_name>Spotted green pufferfish</common_name>
\r
530 <synonym>Chelonodon nigroviridis</synonym>
\r
531 <rank>species</rank>
\r
533 <sequence type="protein">
\r
534 <accession source="uniprot">Q4T8H0</accession>
\r
535 <name>Protein Wnt</name>
\r
536 <mol_seq is_aligned="true">NCSHVPLSP----RQRSLCQKKSF--------LLPSIQDGARLAVSECQNQFRHERWNCSTSQTP---------------------------------SVFGQ-ELTSG--TKETAFIYAVMAAGLVHAVTLFCSHGNR-TECACEGRG--------------------RGLAEER----------------------------------------------------------------------WHWGGCSEHV-RYGTWFSRRFMDGGRN------ASSGGGFTLAAMNQHNGEVGRQAVHRLMPTHCRCH---GVSGSCAAKT--------------------CWK-TTAAFERVGVYLKERYER-SVQVTSPSRKRAR-------------------------------------------------------------------------------------------------KAGLR----PP---------VDGQQLVFIHKSPNYCVEDRRR-GVAGTRGRRC-------------SRS-SG---------GADG-CNLLC--CGRGYNTHVVRHVQ-RCDCK-FV-----WCCYVRCRRCERMNDTHTCK</mol_seq>
\r
537 <annotation ref="GO:0005578">
\r
538 <desc>proteinaceous extracellular matrix</desc>
\r
540 <annotation ref="GO:0007219">
\r
541 <desc>Notch signaling pathway</desc>
\r
543 <annotation ref="GO:0016055">
\r
544 <desc>Wnt signaling pathway</desc>
\r
546 <annotation ref="GO:0060218">
\r
547 <desc>hematopoietic stem cell differentiation</desc>
\r
553 <name>Q75PH5_PARTP/46-355</name>
\r
554 <branch_length>0.13426</branch_length>
\r
561 <id provider="uniprot">114398</id>
\r
563 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
564 <common_name>House spider</common_name>
\r
565 <synonym>Achaearanea tepidariorum</synonym>
\r
566 <rank>species</rank>
\r
568 <sequence type="protein">
\r
569 <accession source="uniprot">Q75PH5</accession>
\r
570 <name>Protein Wnt</name>
\r
571 <gene_name>wnt16-like</gene_name>
\r
572 <mol_seq is_aligned="true">MCSSVPGLV---MQQQKVCQAHPA--------VIKAVSSGAKRGIHECQNQFRHDRWNCTIEGGE---------------------------------SVFDH-TLQRG--SRETAFIYAITSAGATHAVTQACSAGNL-TDCSCDTSR--------------------QGQSMPEG---------------------------------------------------------------------WKWGGCSDNV-RYGMMFARQFVDAPER-----AERKRDVRAL--MNLHNNNAGRLAIARQMELKCRCH---GVSGSCELKT--------------------CWN-KLPSFEQVGHFLKSKYDN-SIQVSLKAKRRLRRRG----------------------------------------------------------------------------------------------KVKRK----VP---------VQKEDLVHIHRSPNYCIEDFKR-GILGTSGRRC-------------NRT-AK---------GPQS-CNLLC--CGRGYNTQVHRRLE-RCQCK-FH-----WCCYVKCKTCETMEEIYTCK</mol_seq>
\r
573 <annotation ref="GO:0005578">
\r
574 <desc>proteinaceous extracellular matrix</desc>
\r
576 <annotation ref="GO:0007275">
\r
577 <desc>multicellular organismal development</desc>
\r
579 <annotation ref="GO:0016055">
\r
580 <desc>Wnt signaling pathway</desc>
\r
586 <name>A7S694_NEMVE/17-329</name>
\r
587 <branch_length>0.16188</branch_length>
\r
594 <id provider="uniprot">45351</id>
\r
596 <scientific_name>Nematostella vectensis</scientific_name>
\r
597 <common_name>Starlet sea anemone</common_name>
\r
598 <rank>species</rank>
\r
600 <sequence type="protein">
\r
601 <accession source="uniprot">A7S694</accession>
\r
602 <name>Protein Wnt</name>
\r
603 <mol_seq is_aligned="true">SCSRVPGLS---LQQLRMCLQKPD--------VIPSVSQGANIGIHECKKQFKYERWNCSTSNDP---------------------------------TVFGT-LLKIA--HKESAFVYAITSAGVVHAVGKSCSKGNL-TECSCESKR--------------------GARNQPKG---------------------------------------------------------------------WEWGGCSDNV-NYGVWLSKTFVDAPEKAD-RRARSQRKARAM--MNLHNNEAGREAVLALMRVQCRCH---GVSSSCAVKT--------------------CSK-SLPKFEEVGEALKAEYKD-AIRAVYIKRKRKLKRKD---------------------------------------------------------------------------------------------NKKLR----IP-----------SSSLVYLDESPNYCYRDKKL-GIDGTSGREC-------------NKN-SS---------GVDG-CDLLC--CGSGYNTQTVRSVH-SCHCR-FI-----WCCNVVCKKCEKIFDRYTCK</mol_seq>
\r
604 <annotation ref="GO:0005578">
\r
605 <desc>proteinaceous extracellular matrix</desc>
\r
607 <annotation ref="GO:0007275">
\r
608 <desc>multicellular organismal development</desc>
\r
610 <annotation ref="GO:0016055">
\r
611 <desc>Wnt signaling pathway</desc>
\r
618 <branch_length>0.00881</branch_length>
\r
619 <confidence type="bootstrap">38</confidence>
\r
621 <branch_length>0.02064</branch_length>
\r
622 <confidence type="bootstrap">70</confidence>
\r
624 <branch_length>0.00813</branch_length>
\r
625 <confidence type="bootstrap">66</confidence>
\r
627 <branch_length>0.01218</branch_length>
\r
628 <confidence type="bootstrap">68</confidence>
\r
630 <branch_length>0.02329</branch_length>
\r
631 <confidence type="bootstrap">96</confidence>
\r
638 <id provider="uniprot">7711</id>
\r
639 <scientific_name>Chordata</scientific_name>
\r
640 <rank>phylum</rank>
\r
643 <branch_length>0.02432</branch_length>
\r
644 <confidence type="bootstrap">99</confidence>
\r
651 <id provider="uniprot">117571</id>
\r
652 <scientific_name>Euteleostomi</scientific_name>
\r
655 <branch_length>0.01427</branch_length>
\r
656 <confidence type="bootstrap">72</confidence>
\r
663 <name>WNT7B_CHICK/37-349</name>
\r
664 <branch_length>0.05239</branch_length>
\r
671 <id provider="uniprot">9031</id>
\r
673 <scientific_name>Gallus gallus</scientific_name>
\r
674 <common_name>Chicken</common_name>
\r
675 <rank>species</rank>
\r
677 <sequence type="protein">
\r
678 <accession source="uniprot">Q3L254</accession>
\r
679 <name>Protein Wnt-7b</name>
\r
680 <gene_name>WNT7B</gene_name>
\r
681 <mol_seq is_aligned="true">ICNKIPGLA---PRQRAICQSRPD--------AIIVIGEGAQMGINECQYQFRYGRWNCSALGEK---------------------------------TVFGQ-ELRVG--SREAAFTYAITAAGVAHAVTAACSQGNL-SNCGCDREK--------------------QGYYNQEE--------------------------------------------------------------------GWKWGGCSADI-RYGIEFSRRFVDARE--------IKKNARRL--MNLHNNEAGRKVLEERMKLECKCH---GVSGSCTTKT--------------------CWT-TLPKFREIGYILKEKYNA-AVQVEVVRASRLRQPTFL-----------------------------------------------------------------------K--------------------IKQIKS-YQKP----------METDLVYIEKSPNYCEEDAST-GSVGTQGRLC-------------NRT-SP---------NADG-CDMMC--CGRGYNTHQYTKVW-QCNCK-FH-----WCCFVKCNTCSERTEVFTCK</mol_seq>
\r
682 <annotation ref="GO:0005109">
\r
683 <desc>frizzled binding</desc>
\r
685 <annotation ref="GO:0005578">
\r
686 <desc>proteinaceous extracellular matrix</desc>
\r
688 <annotation ref="GO:0005615">
\r
689 <desc>extracellular space</desc>
\r
691 <annotation ref="GO:0016055">
\r
692 <desc>Wnt signaling pathway</desc>
\r
694 <annotation ref="GO:0030182">
\r
695 <desc>neuron differentiation</desc>
\r
697 <annotation ref="GO:0045165">
\r
698 <desc>cell fate commitment</desc>
\r
700 <annotation ref="GO:0046330">
\r
701 <desc>positive regulation of JNK cascade</desc>
\r
703 <annotation ref="GO:0070307">
\r
704 <desc>lens fiber cell development</desc>
\r
707 <accession source="CTD">7477</accession>
\r
708 <accession source="KEGG">gga:427937</accession>
\r
709 <accession source="NextBio">20829062</accession>
\r
710 </cross_references>
\r
714 <name>Q4STC2_TETNG/13-326</name>
\r
715 <branch_length>0.07007</branch_length>
\r
722 <id provider="uniprot">99883</id>
\r
724 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
725 <common_name>Spotted green pufferfish</common_name>
\r
726 <synonym>Chelonodon nigroviridis</synonym>
\r
727 <rank>species</rank>
\r
729 <sequence type="protein">
\r
730 <accession source="uniprot">Q4STC2</accession>
\r
731 <name>Protein Wnt</name>
\r
732 <mol_seq is_aligned="true">ICNKIPGLA---PRQRALCQSRPD--------AIIIIGEGAQLGINECQFQFRYSRWNCSTLGER---------------------------------TVFGQ-ELRVG--NREAAFTYAVVAAGVAHAVTKACSQGHL-SQCGCDHEK--------------------QGFHHYHQE-------------------------------------------------------------------GWKWGGCSANV-RYGVEFSRRFVDARE--------IKKNARRL--MNLHNNAAGRKILEERMKLECKCH---GVSGSCTTRT--------------------CWV-TLPKFREIGRLLKERYSA-AVQVEPVRASRLRQPSFL--------------------------------------------------------------------------------------------RLKGARGYQKP----------ADTDLVYLERSPSYCKEDAAT-GSTGTRGRRC-------------DSN-ST---------LTDG-CGAMC--CGRGFDAHRYTRIW-QCNCK-FH-----WCCFVQCSTCSEKSEVFTCK</mol_seq>
\r
733 <annotation ref="GO:0005578">
\r
734 <desc>proteinaceous extracellular matrix</desc>
\r
736 <annotation ref="GO:0007275">
\r
737 <desc>multicellular organismal development</desc>
\r
739 <annotation ref="GO:0016055">
\r
740 <desc>Wnt signaling pathway</desc>
\r
746 <name>Q4RJT5_TETNG/37-350</name>
\r
747 <branch_length>0.07948</branch_length>
\r
754 <id provider="uniprot">99883</id>
\r
756 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
757 <common_name>Spotted green pufferfish</common_name>
\r
758 <synonym>Chelonodon nigroviridis</synonym>
\r
759 <rank>species</rank>
\r
761 <sequence type="protein">
\r
762 <accession source="uniprot">Q4RJT5</accession>
\r
763 <name>Protein Wnt</name>
\r
764 <gene_name>WNT7A</gene_name>
\r
765 <mol_seq is_aligned="true">ICNKIPGLA---PRQRIICQSRPD--------AIIVIGEGAQMGINECQFQFRNWRWNCSALGER---------------------------------TVFGK-ELKVG--SKEAAFTYAIIAAGVAHAITAACTQGNL-GDCSCDKEK--------------------QGFYSIDQ--------------------------------------------------------------------GWKWGGCSADI-SYGLGFSKVFIDARE--------VKQNARTL--MNLHNNEVGRKVLEKSMQLECKCH---GVSGSCTTKT--------------------CWT-TLPKFRELGYILKEKYVH-AVHVEPVKASRNKRPKFL--------------------------------------------------------------------------------------------KVKKPYSYRKP----------MDTDLVYIDKSPNYCEVDHLT-GSLGTHGRVC-------------NKTMMQ---------HISG-CDLMC--CGRGYNTHQYSRVW-QCNCK-FL-----WCCYVKCNTCSERTEVYTCK</mol_seq>
\r
766 <annotation ref="GO:0005578">
\r
767 <desc>proteinaceous extracellular matrix</desc>
\r
769 <annotation ref="GO:0007275">
\r
770 <desc>multicellular organismal development</desc>
\r
772 <annotation ref="GO:0016055">
\r
773 <desc>Wnt signaling pathway</desc>
\r
779 <name>O61700_BRAFL/35-347</name>
\r
780 <branch_length>0.1</branch_length>
\r
787 <id provider="uniprot">7739</id>
\r
789 <scientific_name>Branchiostoma floridae</scientific_name>
\r
790 <common_name>Florida lancelet</common_name>
\r
791 <synonym>Amphioxus</synonym>
\r
792 <rank>species</rank>
\r
794 <sequence type="protein">
\r
795 <accession source="uniprot">O61700</accession>
\r
796 <name>Protein Wnt</name>
\r
797 <gene_name>Wnt7b</gene_name>
\r
798 <mol_seq is_aligned="true">ICNRIPGLV---PRQRAICQTRPD--------LIVAIGEGAQRGIDECRYQFRHSRWNCTGMDND---------------------------------NVFGR-ELRIG--SKEAAFTYAISSAALVHAIVTACSQGNI-SDCGCDRTK--------------------EGDLNDEG---------------------------------------------------------------------WKWGGCSADV-KYGLRFCKKFVDARE--------VEQNARAL--MNLHNNEAGRKVIDQHTRLECKCH---GVSGSCTMKT--------------------CWI-TLPRFREVGNILKEKYHHDAQLVEAVRARRTRRPTFL--------------------------------------------------------------------------------------------KLKNSRTFEKP----------REISLVYLRGSPNYCERDEAT-GSLGTHGRRC-------------NRT-SP---------YQDG-CDLMC--CGRGYNTHQFVKTW-QCNCK-FH-----WCCYVKCNQCSERTEEYTCK</mol_seq>
\r
799 <annotation ref="GO:0005578">
\r
800 <desc>proteinaceous extracellular matrix</desc>
\r
802 <annotation ref="GO:0007275">
\r
803 <desc>multicellular organismal development</desc>
\r
805 <annotation ref="GO:0016055">
\r
806 <desc>Wnt signaling pathway</desc>
\r
809 <accession source="CTD">7215283</accession>
\r
810 </cross_references>
\r
815 <branch_length>0.00853</branch_length>
\r
816 <confidence type="bootstrap">62</confidence>
\r
818 <branch_length>0.02382</branch_length>
\r
819 <confidence type="bootstrap">100</confidence>
\r
826 <id provider="uniprot">114398</id>
\r
827 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
828 <common_name>House spider</common_name>
\r
829 <synonym>Achaearanea tepidariorum</synonym>
\r
830 <rank>species</rank>
\r
833 <name>Q75PH6_PARTP/41-360</name>
\r
834 <branch_length>0.10628</branch_length>
\r
841 <id provider="uniprot">114398</id>
\r
843 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
844 <common_name>House spider</common_name>
\r
845 <synonym>Achaearanea tepidariorum</synonym>
\r
846 <rank>species</rank>
\r
848 <sequence type="protein">
\r
849 <accession source="uniprot">Q75PH6</accession>
\r
850 <name>Protein Wnt</name>
\r
851 <gene_name>wnt7-2</gene_name>
\r
852 <mol_seq is_aligned="true">ICSKIPGLT---PAQQRLCQERPD--------LIVAVGDGARMGINECQKRFRHRRWNCTAIGSS---------------------------------YVFGH-VVVIG--SREAAYTYAVTSAGVTYAITQACSRGTL-WHCGCDISK--------------------DGMLDPEG--------------------------------------------------------------------GWKWGGCSADV-RHGMKMSRQFMDARE--------IEGDERSL--MNLHNNRAGRKAVLFTVQTECKCH---GVSGSCTMKT--------------------CWL-TLPPFSKTGDYLMRRYQI-AKRVFAHFGGPAKKTTRKTR-------------------------------------------------------------------PLF-L-----------------RTKKSKRPHRKP----------RPRDLVYLEKSPNYCEADPMK-GSTGTSGRLC-------------NRT-SR---------GTDG-CDLLC--CGRGYNTHQFTRTA-QCRCK-FH-----WCCYVDCRVCTERTEVYSCK</mol_seq>
\r
853 <annotation ref="GO:0005578">
\r
854 <desc>proteinaceous extracellular matrix</desc>
\r
856 <annotation ref="GO:0007275">
\r
857 <desc>multicellular organismal development</desc>
\r
859 <annotation ref="GO:0016055">
\r
860 <desc>Wnt signaling pathway</desc>
\r
865 <name>Q75PH8_PARTP/42-358</name>
\r
866 <branch_length>0.10483</branch_length>
\r
873 <id provider="uniprot">114398</id>
\r
875 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
876 <common_name>House spider</common_name>
\r
877 <synonym>Achaearanea tepidariorum</synonym>
\r
878 <rank>species</rank>
\r
880 <sequence type="protein">
\r
881 <accession source="uniprot">Q75PH8</accession>
\r
882 <name>Protein Wnt</name>
\r
883 <gene_name>wnt7-1</gene_name>
\r
884 <mol_seq is_aligned="true">ICNKIPGLT---MPQRIFCQTRPD--------IVVAIGEGTRLGVAECQRQFRYHRWNCSTIGSN---------------------------------QVFGH-VIVVG--SREAAYMYSVTSAGVTFVITQSCSRGNV-SDCGCDKSQS-----------------SVKPLNHPTD---------------------------------------------------------------------WKWGGCSVDV-KYGIRLSRKFIDARE--------MEGDARSL--MNLHNNHAGRKAVKHNLKTECKCH---GVSGSCTMKT--------------------CWK-TLPAFAQIGDYLMKAYKQ-SKKVVPHWGPMVTRTPSH-----------------------------------------------------------------------L-------------------KLKKSKRVHRKP----------RPRDLVYLENSPNYCEKDLSR-GSLGTVGREC-------------NRT-SK---------DIDG-CDLLC--CGRGYNTHQYIRTW-QCNCK-FH-----WCCYVNCDVCRERTENYVCK</mol_seq>
\r
885 <annotation ref="GO:0005578">
\r
886 <desc>proteinaceous extracellular matrix</desc>
\r
888 <annotation ref="GO:0007275">
\r
889 <desc>multicellular organismal development</desc>
\r
891 <annotation ref="GO:0016055">
\r
892 <desc>Wnt signaling pathway</desc>
\r
898 <name>A2SVS9_9MOLL/38-351</name>
\r
899 <branch_length>0.12678</branch_length>
\r
906 <id provider="uniprot">6613</id>
\r
908 <scientific_name>Euprymna scolopes</scientific_name>
\r
909 <rank>phylum</rank>
\r
911 <sequence type="protein">
\r
912 <accession source="uniprot">A2SVS9</accession>
\r
913 <name>Protein Wnt</name>
\r
914 <mol_seq is_aligned="true">ICNKIPDLV---PKQRSICQRRPD--------AIVVVGEGVKLGIQECRYQFRNMRWNCTHTRSR--------------------------------NSMFAH-VHLVP--NREAAFSFAIVSAGIAYAITQACSRGNL-SRCGCDKSK--------------------LPNYSHNG---------------------------------------------------------------------WKWGGCSADV-KYGLSFARNFVDIRE--------ITKNARAL--MNLHNNRAGRKAVKDNMVTECKCH---GVSGSCTMKT--------------------CWT-TLRPFRMIGNHLMRKYQT-AKITRVIRGSRTLRPIFL-------------------------------------------------------------------------------------------ILKKSKRQNRKP----------RRSDLVCLEKSPNYCDRDERT-GALGTVGRKC-------------LRE-SK---------QTIG-CDLMC--CGRGYNTHQYTVTV-QCACK-FY-----WCCYVRCEKCSNKTEEYTCK</mol_seq>
\r
915 <annotation ref="GO:0005578">
\r
916 <desc>proteinaceous extracellular matrix</desc>
\r
918 <annotation ref="GO:0007275">
\r
919 <desc>multicellular organismal development</desc>
\r
921 <annotation ref="GO:0016055">
\r
922 <desc>Wnt signaling pathway</desc>
\r
929 <branch_length>0.02882</branch_length>
\r
930 <confidence type="bootstrap">96</confidence>
\r
937 <id provider="uniprot">7147</id>
\r
938 <scientific_name>Diptera</scientific_name>
\r
942 <branch_length>0.0487</branch_length>
\r
943 <confidence type="bootstrap">100</confidence>
\r
950 <id provider="uniprot">7157</id>
\r
951 <scientific_name>Culicidae</scientific_name>
\r
952 <common_name>mosquitos</common_name>
\r
953 <rank>family</rank>
\r
956 <name>Q16Z87_AEDAE/21-350</name>
\r
957 <branch_length>0.11655</branch_length>
\r
964 <id provider="uniprot">7159</id>
\r
966 <scientific_name>Aedes aegypti</scientific_name>
\r
967 <common_name>Yellowfever mosquito</common_name>
\r
968 <synonym>Culex aegypti</synonym>
\r
969 <rank>species</rank>
\r
971 <sequence type="protein">
\r
972 <accession source="uniprot">Q16Z87</accession>
\r
973 <name>Protein Wnt</name>
\r
974 <mol_seq is_aligned="true">LCSRIPGLS---PYQRQLCVEAPD--------AVVSLSTGQKLGAQECQHQFRGHRWNCTQVWKK---------------------------------DMFGH-IVIIG--SREAAFTYGITSAGAVHAITAACAKGNI-TMCGCDSKQ--------------------KMQFSTESD-------------------------------------------------------------------SWKWGGCSADI-GFGMRFTKKFLDARE--------IENDDRSL--MNLHNNRVGRKIVKLLLRTECKCH---GVSGSCAMKT--------------------CWK-SLPPFHAIGDIMMKKYRK-AKMVQATPVVMAMTSTGKINNGQL------------------------------------------------------------QLVLRR-RG---------------KLMQHTSVNSQKP----------KRMELVYLQHSPNYCDRDIAS-GILGTVGRQC-------------NRT-ST---------SMDK-CDLLC--CGRGYNTHQIVKSW-QCNCN-FK-----WCCTVNCDICTERTEEYTCK</mol_seq>
\r
975 <annotation ref="GO:0005578">
\r
976 <desc>proteinaceous extracellular matrix</desc>
\r
978 <annotation ref="GO:0007275">
\r
979 <desc>multicellular organismal development</desc>
\r
981 <annotation ref="GO:0016055">
\r
982 <desc>Wnt signaling pathway</desc>
\r
987 <name>A0NG52_ANOGA/28-354</name>
\r
988 <branch_length>0.19457</branch_length>
\r
995 <id provider="uniprot">7165</id>
\r
997 <scientific_name>Anopheles gambiae</scientific_name>
\r
998 <common_name>African malaria mosquito</common_name>
\r
999 <rank>species</rank>
\r
1001 <sequence type="protein">
\r
1002 <accession source="uniprot">A0NG52</accession>
\r
1003 <name>Protein Wnt</name>
\r
1004 <mol_seq is_aligned="true">LCSRMPGLT---QTQRQICTESSD--------AVVSLASGQWIGASECQKQFHGHRWNCTHVWNT---------------------------------DMFGQ-IVVIG--SREAAYTYAITSAGAVYSITTACAKGNI-TTCGCDMNQ--------------------KIFSSSESE-------------------------------------------------------------------NWKWGGCSVDI-GYGMRFAKKFLDARE--------IENDNRSL--MNMHNNRVGRKPDSILDHTEAG-----NLSWTPHIFTNFSPISLRYPEQFYRPVILNIFA-AFPPYK-----VHVRFHS-PLTISLKGCVKVNNPLLK--------------------------------------------------------------------------------------------NGKTLGDSQIP----------KRTELVYLEPSPNYCERNISI-GVLGTADRNC-------------NRT-SQ---------SIDH-CDLLC--CGRGYNTHQIERTW-QCNCK-FK-----WCCTVTCDVCSERKEAYTCK</mol_seq>
\r
1005 <annotation ref="GO:0005578">
\r
1006 <desc>proteinaceous extracellular matrix</desc>
\r
1008 <annotation ref="GO:0007275">
\r
1009 <desc>multicellular organismal development</desc>
\r
1011 <annotation ref="GO:0016055">
\r
1012 <desc>Wnt signaling pathway</desc>
\r
1018 <name>WNT2_DROME/29-352</name>
\r
1019 <branch_length>0.14749</branch_length>
\r
1022 <green>173</green>
\r
1026 <id provider="uniprot">7227</id>
\r
1027 <code>DROME</code>
\r
1028 <scientific_name>Drosophila melanogaster</scientific_name>
\r
1029 <common_name>Fruit fly</common_name>
\r
1030 <rank>species</rank>
\r
1032 <sequence type="protein">
\r
1033 <accession source="uniprot">P28465</accession>
\r
1034 <name>Protein Wnt-2</name>
\r
1035 <gene_name>Wnt2</gene_name>
\r
1036 <mol_seq is_aligned="true">LCGRIPGLT---PGQRNMCREMPD--------ALIALGEGHQLGAQECQHQFRGHRWNCSEVWQR---------------------------------NVFAH-VIPTA--SREAAYTYAIASAGAAYAVTAACARGNI-STCGCDVRH--------------------KATPTGGGTP----------------------------------------------------------------DEPWKWGGCSADV-DFGMRYARRFMDARE--------LERDSRTL--MNLHNNRAGRTLVKKMLRTDCKCH---GVSGSCVMKT--------------------CWK-SLPPFRLVGDRLMLKYQK-AKTVQAVKGKRGLRLVLSRK-------------------------------------------------------------------KHA-G-----------------TARAQKPVLDWP----------KRMELIYLEASPNYCERSLQT-GSQGTSGRTC-------------QRT-GH---------GPQS-CDLLC--CGRGHNTQHIRRTT-QCRCQ-FR-----WCCEVKCDECDESYEEFTCK</mol_seq>
\r
1037 <annotation ref="GO:0005109">
\r
1038 <desc>frizzled binding</desc>
\r
1040 <annotation ref="GO:0005578">
\r
1041 <desc>proteinaceous extracellular matrix</desc>
\r
1043 <annotation ref="GO:0005615">
\r
1044 <desc>extracellular space</desc>
\r
1046 <annotation ref="GO:0007367">
\r
1047 <desc>segment polarity determination</desc>
\r
1049 <annotation ref="GO:0007424">
\r
1050 <desc>open tracheal system development</desc>
\r
1052 <annotation ref="GO:0007517">
\r
1053 <desc>muscle organ development</desc>
\r
1055 <annotation ref="GO:0016055">
\r
1056 <desc>Wnt signaling pathway</desc>
\r
1058 <annotation ref="GO:0045165">
\r
1059 <desc>cell fate commitment</desc>
\r
1061 <annotation ref="GO:0048675">
\r
1062 <desc>axon extension</desc>
\r
1064 <cross_references>
\r
1065 <accession source="CTD">7472</accession>
\r
1066 <accession source="NextBio">796130</accession>
\r
1067 </cross_references>
\r
1073 <name>Q966W2_HALRO/104-436</name>
\r
1074 <branch_length>0.22451</branch_length>
\r
1081 <id provider="uniprot">7729</id>
\r
1082 <code>HALRO</code>
\r
1083 <scientific_name>Halocynthia roretzi</scientific_name>
\r
1084 <common_name>Sea squirt</common_name>
\r
1085 <synonym>Cynthia roretzi</synonym>
\r
1086 <rank>species</rank>
\r
1088 <sequence type="protein">
\r
1089 <accession source="uniprot">Q966W2</accession>
\r
1090 <name>Protein Wnt</name>
\r
1091 <gene_name>HrWnt-7</gene_name>
\r
1092 <mol_seq is_aligned="true">ICNKIPGLS---PQQRIRCQSRPD--------AIVAVNEGAHKGLQECQRQFRHHKWNCSTQKER---------------------------------SIFGD-DQKLA--TKEAAIHNAIRAAGVLHAIVTACGEGNL-RDCGCDKSL--------------------RGYFPDESKSKWRRQNIML-----------------------------------------------EMSRRSMSLQTWKWGGCSIDL-KHGIQYSKDFWDSRE--------MRRDARGL--MNLHNYEAGRYAVENNVKLECKCH---GVSASCTTKT--------------------CWL-TLPDFRKVGDTLKKSYER-SRRVTVQTGRIRPMYLI---------------------------------------------------------------------------------------------NLEKRGRSNKP----------RKHDLVYLVPSPEYCENDVIS-ETQGTVGRTC-------------NKT-ST---------GVNS-CDNMC--CGRGYRTHHRVHKW-DCKCK-FF-----WCCHVKCKQCRENVEQYTCL</mol_seq>
\r
1093 <annotation ref="GO:0005578">
\r
1094 <desc>proteinaceous extracellular matrix</desc>
\r
1096 <annotation ref="GO:0007275">
\r
1097 <desc>multicellular organismal development</desc>
\r
1099 <annotation ref="GO:0016055">
\r
1100 <desc>Wnt signaling pathway</desc>
\r
1106 <branch_length>0.13752</branch_length>
\r
1107 <confidence type="bootstrap">100</confidence>
\r
1110 <green>132</green>
\r
1114 <id provider="uniprot">45351</id>
\r
1115 <scientific_name>Nematostella vectensis</scientific_name>
\r
1116 <common_name>Starlet sea anemone</common_name>
\r
1117 <rank>species</rank>
\r
1120 <name>Q49N21_NEMVE/28-331</name>
\r
1121 <branch_length>0.0897</branch_length>
\r
1124 <green>132</green>
\r
1128 <id provider="uniprot">45351</id>
\r
1129 <code>NEMVE</code>
\r
1130 <scientific_name>Nematostella vectensis</scientific_name>
\r
1131 <common_name>Starlet sea anemone</common_name>
\r
1132 <rank>species</rank>
\r
1134 <sequence type="protein">
\r
1135 <accession source="uniprot">Q49N21</accession>
\r
1136 <name>Protein Wnt</name>
\r
1137 <mol_seq is_aligned="true">ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVVNRSLLTECTCH---GPSASCVTRT--------------------CSQ-ALPSPRAVSNRLKALYDT-ARRATVYLSSLVRPDDKVE----------------------------------------------------------------------K-------------------V---------------------KPMDLAYLKDSPNYCTKNTLS-KLPGTLGGNC-------------KISDDS---------QEEENCDVMC--CGRGYDTHLITKRW-QCRCK-FV-----WCCNVRCSTCSKRDIVQTCK</mol_seq>
\r
1138 <annotation ref="GO:0005578">
\r
1139 <desc>proteinaceous extracellular matrix</desc>
\r
1141 <annotation ref="GO:0007275">
\r
1142 <desc>multicellular organismal development</desc>
\r
1144 <annotation ref="GO:0016055">
\r
1145 <desc>Wnt signaling pathway</desc>
\r
1150 <name>Q5IHV9_NEMVE/42-359</name>
\r
1151 <branch_length>0.09414</branch_length>
\r
1154 <green>132</green>
\r
1158 <id provider="uniprot">45351</id>
\r
1159 <code>NEMVE</code>
\r
1160 <scientific_name>Nematostella vectensis</scientific_name>
\r
1161 <common_name>Starlet sea anemone</common_name>
\r
1162 <rank>species</rank>
\r
1164 <sequence type="protein">
\r
1165 <accession source="uniprot">Q5IHV9</accession>
\r
1166 <name>Protein Wnt</name>
\r
1167 <gene_name>Wnt7b</gene_name>
\r
1168 <mol_seq is_aligned="true">ICTRIQPLS---AKQMRFCEDKPG--------TMVSISQGYDLGVEECKYQFRNKRWNCSLLGEE---------------------------------RPFGQRAVPG---TKEAAFTHAIISAGIVQAVTLACTQNP--TGCGCDRNK--------------------DGISREG----------------------------------------------------------------------WKWGGCSVNI-GHGLAVAKEFLNAND--------AVRSDIAL--MNRHNNEVGREVIRNNLDLSCKCH---GPSGSCNTKT--------------------CWK-SVPSFRMVGEKLRALYESRQATVKVVAAMKTSKGGQVP---------------------------------------------------------------------AY-I-----------------VVKGTNKVVKPN----------SSANLVYLDNSPSYCNKIKSL-KVPGTVGRVC-------------SRTPES---------AEDVSCEVMC--CGRGYSVREQIKEW-KCHCK-FH-----WCCRVECAKCSKKLMVHTCQ</mol_seq>
\r
1169 <annotation ref="GO:0005578">
\r
1170 <desc>proteinaceous extracellular matrix</desc>
\r
1172 <annotation ref="GO:0007275">
\r
1173 <desc>multicellular organismal development</desc>
\r
1175 <annotation ref="GO:0016055">
\r
1176 <desc>Wnt signaling pathway</desc>
\r
1184 <branch_length>0.00446</branch_length>
\r
1185 <confidence type="bootstrap">6</confidence>
\r
1187 <branch_length>0.00713</branch_length>
\r
1188 <confidence type="bootstrap">26</confidence>
\r
1190 <branch_length>0.01288</branch_length>
\r
1191 <confidence type="bootstrap">37</confidence>
\r
1193 <branch_length>0.01922</branch_length>
\r
1194 <confidence type="bootstrap">62</confidence>
\r
1196 <branch_length>0.06626</branch_length>
\r
1197 <confidence type="bootstrap">100</confidence>
\r
1199 <branch_length>0.04451</branch_length>
\r
1200 <confidence type="bootstrap">100</confidence>
\r
1207 <id provider="uniprot">117571</id>
\r
1208 <scientific_name>Euteleostomi</scientific_name>
\r
1211 <branch_length>0.01499</branch_length>
\r
1212 <confidence type="bootstrap">67</confidence>
\r
1219 <branch_length>0.0197</branch_length>
\r
1220 <confidence type="bootstrap">85</confidence>
\r
1227 <name>Q90YJ8_DANRE/18-337</name>
\r
1228 <branch_length>0.0744</branch_length>
\r
1235 <id provider="uniprot">7955</id>
\r
1236 <code>DANRE</code>
\r
1237 <scientific_name>Danio rerio</scientific_name>
\r
1238 <common_name>Zebrafish</common_name>
\r
1239 <synonym>Brachydanio rerio</synonym>
\r
1240 <rank>species</rank>
\r
1242 <sequence type="protein">
\r
1243 <accession source="uniprot">Q90YJ8</accession>
\r
1244 <name>Protein Wnt</name>
\r
1245 <gene_name>wnt8a</gene_name>
\r
1246 <mol_seq is_aligned="true">ILGHTW-------TMNNLLITGPKAY----LTYANSVRVGAQSGIHECKHQFAWDRWNCPDTA-L---------------------------------QLSTHKGLRSA--TRESSFVHAISAAGVMYTLTRNCSLGDL-NECGCDSSR--------------------NGRLGGRG---------------------------------------------------------------------WLWGGCSDNV-DFGERISKQFVDALE--------TGQDARAA--VNLHNNEAGRLAVKATMKRICRCH---GMSESCTMQT--------------------CWM-QLADFREIGNYLKVKHDQ-AQKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------NRVTMTDAFGSI----------ARTELIYLEDSPDYCAKNLSL-GLPGTEGREC-------------VQHGESLS-----QWERRS-CRRLCHECGLRVEERRTEVVS-SCNCK-FH-----WCCTVKCENCSQVTVKHVCT</mol_seq>
\r
1247 <annotation ref="GO:0005578">
\r
1248 <desc>proteinaceous extracellular matrix</desc>
\r
1250 <annotation ref="GO:0007275">
\r
1251 <desc>multicellular organismal development</desc>
\r
1253 <annotation ref="GO:0016055">
\r
1254 <desc>Wnt signaling pathway</desc>
\r
1256 <cross_references>
\r
1257 <accession source="NextBio">20880563</accession>
\r
1258 </cross_references>
\r
1262 <name>Q564K5_CHICK/19-338</name>
\r
1263 <branch_length>0.06733</branch_length>
\r
1270 <id provider="uniprot">9031</id>
\r
1271 <code>CHICK</code>
\r
1272 <scientific_name>Gallus gallus</scientific_name>
\r
1273 <common_name>Chicken</common_name>
\r
1274 <rank>species</rank>
\r
1276 <sequence type="protein">
\r
1277 <accession source="uniprot">Q564K5</accession>
\r
1278 <name>Protein Wnt</name>
\r
1279 <gene_name>Wnt8c</gene_name>
\r
1280 <mol_seq is_aligned="true">LNAAAW-------SVNNFLMTGPKAY----LTYSSSVAAGAQSGMEECKFQFGWERWNCPESA-L---------------------------------QLSTHNRLRSA--TRETSFVHAISSAGVMYTLTRNCSLGDF-ESCGCDDSR--------------------NGRVGGRG---------------------------------------------------------------------WVWGGCSDNV-EFGERISKLFVDALE--------TGHDTRAL--INLHNNEVGRLAVKATMKRACKCH---GVSGSCSIQT--------------------CWL-QLADFREIGNYLKMKYDQ-AHKLEMDKRRMRAGNSAD-------------------------------------------------------------------------------------------SRGATAETFHHV----------HSTELVFLEDSPDYCTRNASL-GHHGTEGREC-------------LQTGKNLS-----QWERRS-CRRLCTECGLKVEERRTEVVS-SCNCK-FH-----WCCTVRCEQCRQLVAKHFCA</mol_seq>
\r
1281 <annotation ref="GO:0000902">
\r
1282 <desc>cell morphogenesis</desc>
\r
1284 <annotation ref="GO:0005109">
\r
1285 <desc>frizzled binding</desc>
\r
1287 <annotation ref="GO:0005578">
\r
1288 <desc>proteinaceous extracellular matrix</desc>
\r
1290 <annotation ref="GO:0005615">
\r
1291 <desc>extracellular space</desc>
\r
1293 <annotation ref="GO:0007492">
\r
1294 <desc>endoderm development</desc>
\r
1296 <annotation ref="GO:0009949">
\r
1297 <desc>polarity specification of anterior/posterior axis</desc>
\r
1299 <annotation ref="GO:0010085">
\r
1300 <desc>polarity specification of proximal/distal axis</desc>
\r
1302 <annotation ref="GO:0030182">
\r
1303 <desc>neuron differentiation</desc>
\r
1305 <annotation ref="GO:0032880">
\r
1306 <desc>regulation of protein localization</desc>
\r
1308 <annotation ref="GO:0035116">
\r
1309 <desc>embryonic hindlimb morphogenesis</desc>
\r
1311 <annotation ref="GO:0045165">
\r
1312 <desc>cell fate commitment</desc>
\r
1314 <annotation ref="GO:0045743">
\r
1315 <desc>positive regulation of fibroblast growth factor receptor signaling pathway</desc>
\r
1317 <annotation ref="GO:0048561">
\r
1318 <desc>establishment of organ orientation</desc>
\r
1320 <annotation ref="GO:0060021">
\r
1321 <desc>palate development</desc>
\r
1323 <annotation ref="GO:0060828">
\r
1324 <desc>regulation of canonical Wnt signaling pathway</desc>
\r
1326 <annotation ref="GO:0061317">
\r
1327 <desc>canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment</desc>
\r
1333 <name>Q0VBT1_MOUSE/18-337</name>
\r
1334 <branch_length>0.10083</branch_length>
\r
1341 <id provider="uniprot">10090</id>
\r
1342 <code>MOUSE</code>
\r
1343 <scientific_name>Mus musculus</scientific_name>
\r
1344 <common_name>Mouse</common_name>
\r
1345 <rank>species</rank>
\r
1347 <sequence type="protein">
\r
1348 <accession source="uniprot">Q0VBT1</accession>
\r
1349 <name>Protein Wnt</name>
\r
1350 <gene_name>Wnt8a</gene_name>
\r
1351 <mol_seq is_aligned="true">LGASAW-------SVNNFLITGPKAY----LTYTASVALGAQIGIEECKFQFAWERWNCPEHA-F---------------------------------QFSTHNRLRAA--TRETSFIHAIRSAAIMYAVTKNCSMGDL-ENCGCDESQ--------------------NGKTGGHG---------------------------------------------------------------------WIWGGCSDNV-EFGEKISRLFVDSLE--------KGKDARAL--VNLHNNRAGRLAVRASTKRTCKCH---GISGSCSIQT--------------------CWL-QLADFRQMGNYLKAKYDR-ALKIEMDKRQLRAGNRAE-------------------------------------------------------------------------------------------GRWALTEAFLPS----------TEAELIFLEGSPDYCNRNASL-SIQGTEGREC-------------LQNARSAS-----RREQRS-CGRLCTECGLQVEERRAEAVS-SCDCN-FQ-----WCCTVKCGQCRRVVSRYYCT</mol_seq>
\r
1352 <annotation ref="GO:0000902">
\r
1353 <desc>cell morphogenesis</desc>
\r
1355 <annotation ref="GO:0003002">
\r
1356 <desc>regionalization</desc>
\r
1358 <annotation ref="GO:0005109">
\r
1359 <desc>frizzled binding</desc>
\r
1361 <annotation ref="GO:0005515">
\r
1362 <desc>protein binding</desc>
\r
1364 <annotation ref="GO:0005578">
\r
1365 <desc>proteinaceous extracellular matrix</desc>
\r
1367 <annotation ref="GO:0005615">
\r
1368 <desc>extracellular space</desc>
\r
1370 <annotation ref="GO:0007492">
\r
1371 <desc>endoderm development</desc>
\r
1373 <annotation ref="GO:0009949">
\r
1374 <desc>polarity specification of anterior/posterior axis</desc>
\r
1376 <annotation ref="GO:0010085">
\r
1377 <desc>polarity specification of proximal/distal axis</desc>
\r
1379 <annotation ref="GO:0016055">
\r
1380 <desc>Wnt signaling pathway</desc>
\r
1382 <annotation ref="GO:0030182">
\r
1383 <desc>neuron differentiation</desc>
\r
1385 <annotation ref="GO:0032880">
\r
1386 <desc>regulation of protein localization</desc>
\r
1388 <annotation ref="GO:0045165">
\r
1389 <desc>cell fate commitment</desc>
\r
1391 <annotation ref="GO:0048561">
\r
1392 <desc>establishment of organ orientation</desc>
\r
1394 <cross_references>
\r
1395 <accession source="CTD">7478</accession>
\r
1396 <accession source="KEGG">mmu:20890</accession>
\r
1397 <accession source="NextBio">299745</accession>
\r
1398 </cross_references>
\r
1403 <name>WNT8B_HUMAN/15-334</name>
\r
1404 <branch_length>0.0957</branch_length>
\r
1411 <id provider="uniprot">9606</id>
\r
1412 <code>HUMAN</code>
\r
1413 <scientific_name>Homo sapiens</scientific_name>
\r
1414 <common_name>Human</common_name>
\r
1415 <rank>species</rank>
\r
1417 <sequence type="protein">
\r
1418 <accession source="uniprot">Q93098</accession>
\r
1419 <name>Protein Wnt-8b</name>
\r
1420 <gene_name>WNT8B</gene_name>
\r
1421 <mol_seq is_aligned="true">CVLQLSHSW----SVNNFLMTGPKAY----LIYSSSVAAGAQSGIEECKYQFAWDRWNCPERA-L---------------------------------QLSSHGGLRSA--NRETAFVHAISSAGVMYTLTRNCSLGDF-DNCGCDDSR--------------------NGQLGGQG---------------------------------------------------------------------WLWGGCSDNV-GFGEAISKQFVDALE--------TGQDARAA--MNLHNNEAGRKAVKGTMKRTCKCH---GVSGSCTTQT--------------------CWL-QLPEFREVGAHLKEKYHA-ALKVDLLQG---AGNSAA-------------------------------------------------------------------------------------------GRGAIADTFRSI----------STRELVHLEDSPDYCLENKTL-GLLGTEGREC-------------LRRGRALG-----RWERRS-CRRLCGDCGLAVEERRAETVS-SCNCK-FH-----WCCAVRCEQCRRRVTKYFCS</mol_seq>
\r
1422 <annotation ref="GO:0005109">
\r
1423 <desc>frizzled binding</desc>
\r
1425 <annotation ref="GO:0005576">
\r
1426 <desc>extracellular region</desc>
\r
1428 <annotation ref="GO:0005578">
\r
1429 <desc>proteinaceous extracellular matrix</desc>
\r
1431 <annotation ref="GO:0005615">
\r
1432 <desc>extracellular space</desc>
\r
1434 <annotation ref="GO:0007165">
\r
1435 <desc>signal transduction</desc>
\r
1437 <annotation ref="GO:0007369">
\r
1438 <desc>gastrulation</desc>
\r
1440 <annotation ref="GO:0007399">
\r
1441 <desc>nervous system development</desc>
\r
1443 <annotation ref="GO:0010628">
\r
1444 <desc>positive regulation of gene expression</desc>
\r
1446 <annotation ref="GO:0010629">
\r
1447 <desc>negative regulation of gene expression</desc>
\r
1449 <annotation ref="GO:0016055">
\r
1450 <desc>Wnt signaling pathway</desc>
\r
1452 <annotation ref="GO:0030182">
\r
1453 <desc>neuron differentiation</desc>
\r
1455 <annotation ref="GO:0032355">
\r
1456 <desc>response to estradiol</desc>
\r
1458 <annotation ref="GO:0032526">
\r
1459 <desc>response to retinoic acid</desc>
\r
1461 <annotation ref="GO:0045165">
\r
1462 <desc>cell fate commitment</desc>
\r
1464 <annotation ref="GO:0048263">
\r
1465 <desc>determination of dorsal identity</desc>
\r
1467 <annotation ref="GO:0071300">
\r
1468 <desc>cellular response to retinoic acid</desc>
\r
1470 <cross_references>
\r
1471 <accession source="CTD">7479</accession>
\r
1472 <accession source="KEGG">hsa:7479</accession>
\r
1473 <accession source="MIM">601396</accession>
\r
1474 <accession source="NextBio">29296</accession>
\r
1475 <accession source="PharmGKB">PA37390</accession>
\r
1476 </cross_references>
\r
1481 <branch_length>0.00972</branch_length>
\r
1482 <confidence type="bootstrap">62</confidence>
\r
1484 <name>Q9U416_BRABE/27-337</name>
\r
1485 <branch_length>0.14387</branch_length>
\r
1492 <id provider="uniprot">7741</id>
\r
1493 <code>BRABE</code>
\r
1494 <scientific_name>Branchiostoma belcheri</scientific_name>
\r
1495 <common_name>Amphioxus</common_name>
\r
1496 <rank>species</rank>
\r
1498 <sequence type="protein">
\r
1499 <accession source="uniprot">Q9U416</accession>
\r
1500 <name>Protein Wnt</name>
\r
1501 <gene_name>wnt8</gene_name>
\r
1502 <mol_seq is_aligned="true">L-------------QNNILITGPKSSFQASLTYASSVAAGAQTAMEECKYQFSWDRWNCTDNA-L---------------------------------AMFKPNTLP-A--NRETSFVHAISAAGVMYVLTRNCSKGAF-EQCGCDVTN--------------------NGKKAEGG---------------------------------------------------------------------WTWGGCSDDI-AFGERISKMYSDGVE--------NGQDARAA--MNLHNNDVGRKAVRQTMKRVCKCH---GVSGSCTTKT--------------------CWL-QLADFRAIGVFLKKKYKK-ADKVDYVRGQLTENNSAS-------------------------------------------------------------------------------------------SKRNTG----------------LKKDMVFLEDSPDYCRENLTV-GSRGTLGREC-------------LRGGKNRD-----KYEKKS-CKRLCKDCGYVPKRITTEVTS-SCNCK-FH-----WCCSVKCSQCTKTVTKYICV</mol_seq>
\r
1503 <annotation ref="GO:0005578">
\r
1504 <desc>proteinaceous extracellular matrix</desc>
\r
1506 <annotation ref="GO:0007275">
\r
1507 <desc>multicellular organismal development</desc>
\r
1509 <annotation ref="GO:0016055">
\r
1510 <desc>Wnt signaling pathway</desc>
\r
1515 <name>Q6QWF4_HELTB/9-337</name>
\r
1516 <branch_length>0.21462</branch_length>
\r
1523 <id provider="uniprot">7635</id>
\r
1524 <code>HELTB</code>
\r
1525 <scientific_name>Heliocidaris tuberculata</scientific_name>
\r
1526 <common_name>Sea urchin</common_name>
\r
1527 <rank>species</rank>
\r
1529 <sequence type="protein">
\r
1530 <accession source="uniprot">Q6QWF4</accession>
\r
1531 <name>Protein Wnt</name>
\r
1532 <mol_seq is_aligned="true">S------------PASNVLLAGSKSKS--HVTYIDSVSAGIQNAVQECQYQFKWDKWNCPEA------------------------------------SVFTNT---QA--NREMSFVQAIASAGVMYSLTRNCSQGAF-EDCGCDERR--------------------NGDTGGEG---------------------------------------------------------------------WTWGGCSDNV-RFGERMASDIMDDSE--------KSQGAISV--MNLHNNEAGRKAVKQTLQRTCKCH---GVSGSCSLQT--------------------CWN-HVANFRVVGDEIKRKYFK-AVRVDFVSGKLIDGNRPE-------------------------------------------------------------------------------------------DRFPRAVMTASL----------NRRDLVFLDQSPDYCRANLTI-GITGTAGRECMVRQDVDDSSSSSSLT-KDMTSPSSFRWVKQS-CSRLCRSCGMEIRQTEVVITS-SCNCN-FV-----WCCQVKCDTCRRTVTRRTCQ</mol_seq>
\r
1533 <annotation ref="GO:0005578">
\r
1534 <desc>proteinaceous extracellular matrix</desc>
\r
1536 <annotation ref="GO:0007275">
\r
1537 <desc>multicellular organismal development</desc>
\r
1539 <annotation ref="GO:0016055">
\r
1540 <desc>Wnt signaling pathway</desc>
\r
1547 <name>Q5IHV8_NEMVE/13-321</name>
\r
1548 <branch_length>0.23494</branch_length>
\r
1551 <green>132</green>
\r
1555 <id provider="uniprot">45351</id>
\r
1556 <code>NEMVE</code>
\r
1557 <scientific_name>Nematostella vectensis</scientific_name>
\r
1558 <common_name>Starlet sea anemone</common_name>
\r
1559 <rank>species</rank>
\r
1561 <sequence type="protein">
\r
1562 <accession source="uniprot">Q5IHV8</accession>
\r
1563 <name>Protein Wnt</name>
\r
1564 <gene_name>Wnt8b</gene_name>
\r
1565 <mol_seq is_aligned="true">VLKVLRGRE-----------AYDK--------LVSSIQKGAKLGLQECRSQFRNEKWNCTMAVKTKNKS------------------------TSKQNPAYVMSMVPHA--TREMAFAHGISAAGVTFALTMDCRLGAF-EDCSCIHGK--------------------SEGNKGN----------------------------------------------------------------------W-WGGCNENV-KFGEVMARHFLEALQ--------SGKDERSL--LNVHNNEVGRKAVRATLKRECRCH---GISGSCSTRT--------------------CWR-KLSSFAEVGQYLVEKYST-AKRVIFQNGNFYELTMLG-------------------------------------------------------------------------------------------TRPISK----------------KDNNFIYSESSPDYCQRNMTV-GSAGVLGREC-------------EGS-KD---------ELVR-CRQLCDSCRFDTQEFTEIKNT-FCNCK-FH-----WCCKVKCMTCKETTRKTRCV</mol_seq>
\r
1566 <annotation ref="GO:0005578">
\r
1567 <desc>proteinaceous extracellular matrix</desc>
\r
1569 <annotation ref="GO:0007275">
\r
1570 <desc>multicellular organismal development</desc>
\r
1572 <annotation ref="GO:0016055">
\r
1573 <desc>Wnt signaling pathway</desc>
\r
1579 <branch_length>0.00862</branch_length>
\r
1580 <confidence type="bootstrap">33</confidence>
\r
1582 <branch_length>0.02008</branch_length>
\r
1583 <confidence type="bootstrap">88</confidence>
\r
1585 <branch_length>0.02595</branch_length>
\r
1586 <confidence type="bootstrap">92</confidence>
\r
1588 <name>WNT8_DROME/15-309</name>
\r
1589 <branch_length>0.3095</branch_length>
\r
1592 <green>173</green>
\r
1596 <id provider="uniprot">7227</id>
\r
1597 <code>DROME</code>
\r
1598 <scientific_name>Drosophila melanogaster</scientific_name>
\r
1599 <common_name>Fruit fly</common_name>
\r
1600 <rank>species</rank>
\r
1602 <sequence type="protein">
\r
1603 <accession source="uniprot">Q9VFX1</accession>
\r
1604 <name>Wnt inhibitor of Dorsal protein</name>
\r
1605 <gene_name>wntD</gene_name>
\r
1606 <mol_seq is_aligned="true">LAAVLEPMSYYQYTQFQAPLSWED-----------ITGKGLKQALDSCQQSFQWQRWNCPSQD-F--------------------------------VQKNSKPEENSP--NREDVYVAAISMAAIVHTLTKDCANGVI-AGCGCTENA--------------------------------------------------------------------------------------------------LNVPCAHEPTKALEQYEKHFGSGSG------------------AIGHNRRVVGALLQRSLEQECRCKQPGAVQGECQEEE--------------------CVA-VLKPFEAIAQDLLQMYDD-AIQLEGASSNLKIMWQNI-----------------------------------------------------------------------------------------------------------------PLDSLVFMQDSPNYCERDATG-LWKGTRGRQC-------------SKD-GSG------SLEERLSCQQLCRVCGYRVRSQHVRTER-RCNCK-LV-----WGFRLQCDVCVQLERQYSCY</mol_seq>
\r
1607 <annotation ref="GO:0005109">
\r
1608 <desc>frizzled binding</desc>
\r
1610 <annotation ref="GO:0005576">
\r
1611 <desc>extracellular region</desc>
\r
1613 <annotation ref="GO:0005578">
\r
1614 <desc>proteinaceous extracellular matrix</desc>
\r
1616 <annotation ref="GO:0005615">
\r
1617 <desc>extracellular space</desc>
\r
1619 <annotation ref="GO:0007280">
\r
1620 <desc>pole cell migration</desc>
\r
1622 <annotation ref="GO:0007370">
\r
1623 <desc>ventral furrow formation</desc>
\r
1625 <annotation ref="GO:0016055">
\r
1626 <desc>Wnt signaling pathway</desc>
\r
1628 <annotation ref="GO:0030182">
\r
1629 <desc>neuron differentiation</desc>
\r
1631 <annotation ref="GO:0045165">
\r
1632 <desc>cell fate commitment</desc>
\r
1634 <annotation ref="GO:0045995">
\r
1635 <desc>regulation of embryonic development</desc>
\r
1637 <annotation ref="GO:0050830">
\r
1638 <desc>defense response to Gram-positive bacterium</desc>
\r
1640 <cross_references>
\r
1641 <accession source="CTD">41633</accession>
\r
1642 <accession source="NextBio">824739</accession>
\r
1643 <accession source="PDB" comment="X-ray">4KRR</accession>
\r
1644 </cross_references>
\r
1648 <name>Q675W2_OIKDI/28-306</name>
\r
1649 <branch_length>0.27475</branch_length>
\r
1656 <id provider="uniprot">34765</id>
\r
1657 <code>OIKDI</code>
\r
1658 <scientific_name>Oikopleura dioica</scientific_name>
\r
1659 <common_name>Tunicate</common_name>
\r
1660 <rank>species</rank>
\r
1662 <sequence type="protein">
\r
1663 <accession source="uniprot">Q675W2</accession>
\r
1664 <name>Protein Wnt</name>
\r
1665 <mol_seq is_aligned="true">ICE-FEGLT---RPQKRLCQKYPK--------FQPALKAASLSTINLCKSSMKGHLWGCKGAD-K---------------------------------LPAIGPELSEA--TSESAFVHALGAGQLLAALKTICRTGAS-GSCDEDELR------------------------------------------------------------------------------------------------------------MFAIQFTDVLAMSRR------------AKGQKTVELHNNDVGRSTADRHSRLVCKCH---GQSGSCTQKT--------------------CWR-GSPDPEKVATELSTKYES-AAKVRAQDELPAIFRQYV-----------------------------------------------------------------------------------------------------------------VRDRLLYIKNSINHCEI---------TKGREC-------------NPY-SS---------EKSS-CERLC--CGRGFITRLHKEPRRECKMQTIEVDGSLWPAGITCKTVYDSSISHSCR</mol_seq>
\r
1666 <annotation ref="GO:0005578">
\r
1667 <desc>proteinaceous extracellular matrix</desc>
\r
1669 <annotation ref="GO:0007275">
\r
1670 <desc>multicellular organismal development</desc>
\r
1672 <annotation ref="GO:0016055">
\r
1673 <desc>Wnt signaling pathway</desc>
\r
1675 <cross_references>
\r
1676 <accession source="CTD">6166716</accession>
\r
1677 </cross_references>
\r
1682 <branch_length>0.12867</branch_length>
\r
1683 <confidence type="bootstrap">100</confidence>
\r
1690 <id provider="uniprot">119089</id>
\r
1691 <scientific_name>Chromadorea</scientific_name>
\r
1692 <rank>class</rank>
\r
1695 <name>LIN44_CAEEL/62-339</name>
\r
1696 <branch_length>0.12154</branch_length>
\r
1703 <id provider="uniprot">6239</id>
\r
1704 <code>CAEEL</code>
\r
1705 <scientific_name>Caenorhabditis elegans</scientific_name>
\r
1706 <rank>species</rank>
\r
1708 <sequence type="protein">
\r
1709 <accession source="uniprot">Q27886</accession>
\r
1710 <name>Abnormal cell lineage protein 44</name>
\r
1711 <gene_name>lin-44</gene_name>
\r
1712 <mol_seq is_aligned="true">ALR----------SIQLACRTHPA--------TVISAFEGVQEGLQNCANRLRFQQWDCSEAGN----------------------------------IMHDPPLLRQG--FRESSLIWALSSASAAWGVATACAQGWI-DDCACNNQM--------------------GQNE-------------------------------------------------------------------------YEFGGCTHGV-QHGITASRKLLTKVG--------AVNTLLRK--VEKHNLKAGRLAIKKTLISSCKCH---GVSGSCQQKT--------------------CWK-RTATLEHITDYLVEKYAR-AKLYTDDSVV-------------------------------------------------------------------------------------------------------------------------KTTDLIYLEASPDVC-------KAKSVAGRVC-------------AWRNET---------HTQGDCDRLC--CGNGFSIRHEVVRV-KCDCE-FV-----WCCNLVCKDCIQHRWISTCN</mol_seq>
\r
1713 <annotation ref="GO:0005109">
\r
1714 <desc>frizzled binding</desc>
\r
1716 <annotation ref="GO:0005578">
\r
1717 <desc>proteinaceous extracellular matrix</desc>
\r
1719 <annotation ref="GO:0005615">
\r
1720 <desc>extracellular space</desc>
\r
1722 <annotation ref="GO:0007163">
\r
1723 <desc>establishment or maintenance of cell polarity</desc>
\r
1725 <annotation ref="GO:0016055">
\r
1726 <desc>Wnt signaling pathway</desc>
\r
1728 <annotation ref="GO:0030182">
\r
1729 <desc>neuron differentiation</desc>
\r
1731 <annotation ref="GO:0040025">
\r
1732 <desc>vulval development</desc>
\r
1734 <annotation ref="GO:0040028">
\r
1735 <desc>regulation of vulval development</desc>
\r
1737 <annotation ref="GO:0045138">
\r
1738 <desc>tail tip morphogenesis</desc>
\r
1740 <annotation ref="GO:0046662">
\r
1741 <desc>regulation of oviposition</desc>
\r
1743 <annotation ref="GO:0060573">
\r
1744 <desc>cell fate specification involved in pattern specification</desc>
\r
1746 <cross_references>
\r
1747 <accession source="CTD">171994</accession>
\r
1748 <accession source="NextBio">873579</accession>
\r
1749 </cross_references>
\r
1753 <name>Q5IWQ9_PRIPA/94-384</name>
\r
1754 <branch_length>0.11121</branch_length>
\r
1761 <id provider="uniprot">54126</id>
\r
1762 <code>PRIPA</code>
\r
1763 <scientific_name>Pristionchus pacificus</scientific_name>
\r
1764 <common_name>Parasitic nematode</common_name>
\r
1765 <rank>species</rank>
\r
1767 <sequence type="protein">
\r
1768 <accession source="uniprot">Q5IWQ9</accession>
\r
1769 <name>Protein Wnt</name>
\r
1770 <gene_name>wnt</gene_name>
\r
1771 <mol_seq is_aligned="true">GCPNLLLLSRLFGHIRVECRTRPS--------TAIAAYEGIKDAMNECSSRMKFLPWDCSQTED----------------------------------IMHDPILLKYG--YKESALVWALSSAGSAWAVATACAQGWL-SDCECSKEM--------------------EEAGKH-----------------------------------------------------------------------WEWGGCSAGV-QHGITTSRKMLTRTS-------GGTNSALRK--LEKHNLKAGRLAVKKTLTSLCKCH---GVSGSCQQKT--------------------CWK-QPASMTTITKHLIEKYHK-AKVMTDEGKL-------------------------------------------------------------------------------------------------------------------------RNNDLLFLEASPDHC-------AVRGEKPRVC-------------GWRNET---------HAQGDCGRLC--CGRGFNITHEVNRY-KCDCQ-FV-----WCCQLQCNECIQHRWVSTCT</mol_seq>
\r
1772 <annotation ref="GO:0005578">
\r
1773 <desc>proteinaceous extracellular matrix</desc>
\r
1775 <annotation ref="GO:0007275">
\r
1776 <desc>multicellular organismal development</desc>
\r
1778 <annotation ref="GO:0016055">
\r
1779 <desc>Wnt signaling pathway</desc>
\r
1786 <name>A5PFR0_HYDVU/21-343</name>
\r
1787 <branch_length>0.32243</branch_length>
\r
1790 <green>132</green>
\r
1794 <id provider="uniprot">6087</id>
\r
1795 <code>HYDVU</code>
\r
1796 <scientific_name>Hydra vulgaris</scientific_name>
\r
1797 <common_name>Hydra</common_name>
\r
1798 <synonym>Hydra attenuata</synonym>
\r
1799 <rank>species</rank>
\r
1801 <sequence type="protein">
\r
1802 <accession source="uniprot">A5PFR0</accession>
\r
1803 <name>Protein Wnt</name>
\r
1804 <gene_name>wnt-8/11</gene_name>
\r
1805 <mol_seq is_aligned="true">LCSSMAALQ----RKLHVTSKKVSP------DVVNSVILAYKDAFKNCYKNFKFERWNCPVPQAFSQ----------------------------INTPVSLTYTYPHA--TKETAYVYAIVAASILNRIVRNCRQGVY-QDLTCVKHS--------------------INGTQS-----------------------------------------------------------------------NQDESFSVNI-SNALKLVKRIIKIFDY-----KYVRDEKRKA--FNWNNSVIGLKAFTERLTTVCKCH---GLSGYCSSKT--------------------CWKSSLSSLKETAVELMTLYHG-AKKYEEQHQQSDPSTQST-------------------------------------------------------------------------------------------NVMKNFISKDVP----------NSSVLVYLTESPDYCKKNSSI-EVQGTLNREC-----------------NH---------HLDDSCKKLCSSCGYRKHSFVKTIENMQCNCK-FR-----WCCTVVCEKCVSRQISSRCS</mol_seq>
\r
1806 <annotation ref="GO:0005578">
\r
1807 <desc>proteinaceous extracellular matrix</desc>
\r
1809 <annotation ref="GO:0007275">
\r
1810 <desc>multicellular organismal development</desc>
\r
1812 <annotation ref="GO:0016055">
\r
1813 <desc>Wnt signaling pathway</desc>
\r
1820 <branch_length>0.01538</branch_length>
\r
1821 <confidence type="bootstrap">40</confidence>
\r
1823 <branch_length>0.01916</branch_length>
\r
1824 <confidence type="bootstrap">89</confidence>
\r
1826 <branch_length>0.08359</branch_length>
\r
1827 <confidence type="bootstrap">100</confidence>
\r
1834 <id provider="uniprot">117571</id>
\r
1835 <scientific_name>Euteleostomi</scientific_name>
\r
1838 <branch_length>0.01191</branch_length>
\r
1839 <confidence type="bootstrap">54</confidence>
\r
1846 <branch_length>0.01214</branch_length>
\r
1847 <confidence type="bootstrap">72</confidence>
\r
1854 <branch_length>0.01495</branch_length>
\r
1855 <confidence type="bootstrap">59</confidence>
\r
1862 <name>Q3L250_CHICK/18-321</name>
\r
1863 <branch_length>0.07613</branch_length>
\r
1870 <id provider="uniprot">9031</id>
\r
1871 <code>CHICK</code>
\r
1872 <scientific_name>Gallus gallus</scientific_name>
\r
1873 <common_name>Chicken</common_name>
\r
1874 <rank>species</rank>
\r
1876 <sequence type="protein">
\r
1877 <accession source="uniprot">Q3L250</accession>
\r
1878 <name>Protein Wnt</name>
\r
1879 <gene_name>WNT9b</gene_name>
\r
1880 <mol_seq is_aligned="true">QCDLLKLSR----KQKRLCRREPG--------LAETLRDAIRLGIMECQFQFRSERWNCSLEG--------------------------------------RTSLLKRG--FKETAFLYAVSSAALTHSLARACSAGRM-ERCTCDDSP--------------------DLENRKA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKR--------IGKDLRAK--VDIHNTNVGIKAVKNGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHEIGRLLKLRYDD-AVKVFSTTNDAVGHSELA--------------------------------------------------------------------------------------------SPQRQSHPTKHHA------SPRATDLVYVEDSPSFCRPSKYS---LGTAGRTC-------------SRE-GN--------------CDSMC--CGRGYNTQSRLVTF-SCHCQ-VQ-----WCCYVECQQCMQEEVVYSCK</mol_seq>
\r
1881 <annotation ref="GO:0001658">
\r
1882 <desc>branching involved in ureteric bud morphogenesis</desc>
\r
1884 <annotation ref="GO:0001701">
\r
1885 <desc>in utero embryonic development</desc>
\r
1887 <annotation ref="GO:0001932">
\r
1888 <desc>regulation of protein phosphorylation</desc>
\r
1890 <annotation ref="GO:0003339">
\r
1891 <desc>regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis</desc>
\r
1893 <annotation ref="GO:0005578">
\r
1894 <desc>proteinaceous extracellular matrix</desc>
\r
1896 <annotation ref="GO:0009786">
\r
1897 <desc>regulation of asymmetric cell division</desc>
\r
1899 <annotation ref="GO:0030539">
\r
1900 <desc>male genitalia development</desc>
\r
1902 <annotation ref="GO:0035150">
\r
1903 <desc>regulation of tube size</desc>
\r
1905 <annotation ref="GO:0043085">
\r
1906 <desc>positive regulation of catalytic activity</desc>
\r
1908 <annotation ref="GO:0048701">
\r
1909 <desc>embryonic cranial skeleton morphogenesis</desc>
\r
1911 <annotation ref="GO:0060021">
\r
1912 <desc>palate development</desc>
\r
1914 <annotation ref="GO:0060071">
\r
1915 <desc>Wnt signaling pathway, planar cell polarity pathway</desc>
\r
1917 <annotation ref="GO:0061038">
\r
1918 <desc>uterus morphogenesis</desc>
\r
1920 <annotation ref="GO:0061303">
\r
1921 <desc>cornea development in camera-type eye</desc>
\r
1923 <annotation ref="GO:0072003">
\r
1924 <desc>kidney rudiment formation</desc>
\r
1926 <annotation ref="GO:0072044">
\r
1927 <desc>collecting duct development</desc>
\r
1929 <annotation ref="GO:0072046">
\r
1930 <desc>establishment of planar polarity involved in nephron morphogenesis</desc>
\r
1932 <annotation ref="GO:0072170">
\r
1933 <desc>metanephric tubule development</desc>
\r
1935 <annotation ref="GO:0072181">
\r
1936 <desc>mesonephric duct formation</desc>
\r
1941 <name>Q6ZSP0_HUMAN/73-350</name>
\r
1942 <branch_length>0.11391</branch_length>
\r
1949 <id provider="uniprot">9606</id>
\r
1950 <code>HUMAN</code>
\r
1951 <scientific_name>Homo sapiens</scientific_name>
\r
1952 <common_name>Human</common_name>
\r
1953 <rank>species</rank>
\r
1955 <sequence type="protein">
\r
1956 <accession source="uniprot">Q6ZSP0</accession>
\r
1957 <name>Protein Wnt</name>
\r
1958 <mol_seq is_aligned="true">PPLAL--------RGRQATSKLPP--------FLSS-----PFPPSLC-------PW-----------------------------------------------VPDPG--FKETAFLYAVSSAALTHTLARACSAGRM-ERCTCDDSP--------------------GLESRQA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLSNFLGSKR--------GNKDLRAR--ADAHNTHVGIKAVKSGLRTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFRETGQVLKLRYDS-AVKVSSATNEALGRLELW--------------------------------------------------------------------------------------------APARQGSLTKGL-------APRSGDLVYMEDSPSFCRPSKYS---PGTAGRVC-------------SRE-AS--------------CSSLC--CGRGYDTQSRLVAF-SCHCQ-VQ-----WCCYVECQQCVQEELVYTCK</mol_seq>
\r
1959 <annotation ref="GO:0005578">
\r
1960 <desc>proteinaceous extracellular matrix</desc>
\r
1962 <annotation ref="GO:0007275">
\r
1963 <desc>multicellular organismal development</desc>
\r
1965 <annotation ref="GO:0016055">
\r
1966 <desc>Wnt signaling pathway</desc>
\r
1972 <name>Q4S992_TETNG/27-324</name>
\r
1973 <branch_length>0.09279</branch_length>
\r
1980 <id provider="uniprot">99883</id>
\r
1981 <code>TETNG</code>
\r
1982 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
1983 <common_name>Spotted green pufferfish</common_name>
\r
1984 <synonym>Chelonodon nigroviridis</synonym>
\r
1985 <rank>species</rank>
\r
1987 <sequence type="protein">
\r
1988 <accession source="uniprot">Q4S992</accession>
\r
1989 <name>Protein Wnt</name>
\r
1990 <mol_seq is_aligned="true">QCEQMSLSR----RQKRLCRREPG--------LAETLRESVRLSLLECRYQFRNERWNCSLDG--------------------------------------RGSLLKRA--FKETAFLLAVSSAALTHALAKACSSGRM-ERCTCDESP--------------------GIQHREA----------------------------------------------------------------------WQWGVCGDNL-KYSTKFLKKFLGQKK--------VSKDLRAQ--VDAQNINVGVRAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLAPFHDTGRLLKYRYDN-AVRVLSVTNAATGETELA--------------------------------------------------------------------------------------------GPRRHSQNL------------RTTDLVYLEESPSFCRASRYS---PGTGGRSC-------------AKD-TS--------------CQSLC--CGRGYNTAMHLTSL-SCHCQ-VR-----WCCHVECQTCVREEEVYTCK</mol_seq>
\r
1991 <annotation ref="GO:0005578">
\r
1992 <desc>proteinaceous extracellular matrix</desc>
\r
1994 <annotation ref="GO:0007275">
\r
1995 <desc>multicellular organismal development</desc>
\r
1997 <annotation ref="GO:0016055">
\r
1998 <desc>Wnt signaling pathway</desc>
\r
2004 <name>A4ZGP2_XENTR/59-356</name>
\r
2005 <branch_length>0.09489</branch_length>
\r
2012 <id provider="uniprot">8364</id>
\r
2013 <code>XENTR</code>
\r
2014 <scientific_name>Xenopus tropicalis</scientific_name>
\r
2015 <common_name>Western clawed frog</common_name>
\r
2016 <synonym>Silurana tropicalis</synonym>
\r
2017 <rank>species</rank>
\r
2019 <sequence type="protein">
\r
2020 <accession source="uniprot">A4ZGP2</accession>
\r
2021 <name>Protein Wnt</name>
\r
2022 <gene_name>wnt9b</gene_name>
\r
2023 <mol_seq is_aligned="true">QCDLLPLTR----RQRRLCRKEPG--------LAEALREAVRLGVVECQFQLRSERWNCSLQE--------------------------------------RGNLLKRG--FKETAFMYAISAASLTHSLAKACSGGRM-ERCTCDDSQ--------------------GLESQQA----------------------------------------------------------------------WQWGVCGDNL-RHSTRFLQNFLRQKK--------GGRDARAK--MDLHNSNAGIKAVKSGLKTTCKCH---GVSGSCAVRT--------------------CWK-QLSPFHETGALLKAKYEN-AIKIHGASNEAVGGHE----------------------------------------------------------------------------------------------SLGHTFGGRHA----------RSTDFLYLEESPNFCRPSRFS---PGTAGRTC-------------LRE-NT--------------CDSLC--CGRGYNIQTRMVTF-SCHCQ-VH-----WCCHVECQKCVQQQETYTCK</mol_seq>
\r
2024 <annotation ref="GO:0005578">
\r
2025 <desc>proteinaceous extracellular matrix</desc>
\r
2027 <annotation ref="GO:0007275">
\r
2028 <desc>multicellular organismal development</desc>
\r
2030 <annotation ref="GO:0016055">
\r
2031 <desc>Wnt signaling pathway</desc>
\r
2033 <cross_references>
\r
2034 <accession source="CTD">7484</accession>
\r
2035 <accession source="KEGG">xtr:100125200</accession>
\r
2036 </cross_references>
\r
2041 <name>WNT9A_HUMAN/58-364</name>
\r
2042 <branch_length>0.12754</branch_length>
\r
2049 <id provider="uniprot">9606</id>
\r
2050 <code>HUMAN</code>
\r
2051 <scientific_name>Homo sapiens</scientific_name>
\r
2052 <common_name>Human</common_name>
\r
2053 <rank>species</rank>
\r
2055 <sequence type="protein">
\r
2056 <accession source="uniprot">O14904</accession>
\r
2057 <name>Protein Wnt-9a</name>
\r
2058 <gene_name>WNT9A</gene_name>
\r
2059 <mol_seq is_aligned="true">ACDRLKLER----KQRRMCRRDPG--------VAETLVEAVSMSALECQFQFRFERWNCTLEG------------------------------------RYRASLLKRG--FKETAFLYAISSAGLTHALAKACSAGRM-ERCTCDEAP--------------------DLENREA----------------------------------------------------------------------WQWGGCGDNL-KYSSKFVKEFLGRRS---------SKDLRAR--VDFHNNLVGVKVIKAGVETTCKCH---GVSGSCTVRT--------------------CWR-QLAPFHEVGKHLKHKYET-ALKVGSTTNEAAGEAGAI--------------------------------------------------------------------------------------------SPPRGRASGAGGSD----PLPRTPELVHLDDSPSFCLAGRFS---PGTAGRRC-------------HRE-KN--------------CESIC--CGRGHNTQSRVVTR-PCQCQ-VR-----WCCYVECRQCTQREEVYTCK</mol_seq>
\r
2060 <annotation ref="GO:0005109">
\r
2061 <desc>frizzled binding</desc>
\r
2063 <annotation ref="GO:0005576">
\r
2064 <desc>extracellular region</desc>
\r
2066 <annotation ref="GO:0005578">
\r
2067 <desc>proteinaceous extracellular matrix</desc>
\r
2069 <annotation ref="GO:0005615">
\r
2070 <desc>extracellular space</desc>
\r
2072 <annotation ref="GO:0007093">
\r
2073 <desc>mitotic cell cycle checkpoint</desc>
\r
2075 <annotation ref="GO:0007267">
\r
2076 <desc>cell-cell signaling</desc>
\r
2078 <annotation ref="GO:0007275">
\r
2079 <desc>multicellular organismal development</desc>
\r
2081 <annotation ref="GO:0008285">
\r
2082 <desc>negative regulation of cell proliferation</desc>
\r
2084 <annotation ref="GO:0016055">
\r
2085 <desc>Wnt signaling pathway</desc>
\r
2087 <annotation ref="GO:0030182">
\r
2088 <desc>neuron differentiation</desc>
\r
2090 <annotation ref="GO:0032331">
\r
2091 <desc>negative regulation of chondrocyte differentiation</desc>
\r
2093 <annotation ref="GO:0035115">
\r
2094 <desc>embryonic forelimb morphogenesis</desc>
\r
2096 <annotation ref="GO:0043154">
\r
2097 <desc>negative regulation of cysteine-type endopeptidase activity involved in apoptotic process</desc>
\r
2099 <annotation ref="GO:0045165">
\r
2100 <desc>cell fate commitment</desc>
\r
2102 <annotation ref="GO:0045597">
\r
2103 <desc>positive regulation of cell differentiation</desc>
\r
2105 <annotation ref="GO:0045880">
\r
2106 <desc>positive regulation of smoothened signaling pathway</desc>
\r
2108 <annotation ref="GO:0048704">
\r
2109 <desc>embryonic skeletal system morphogenesis</desc>
\r
2111 <annotation ref="GO:0060070">
\r
2112 <desc>canonical Wnt signaling pathway</desc>
\r
2114 <annotation ref="GO:0060548">
\r
2115 <desc>negative regulation of cell death</desc>
\r
2117 <annotation ref="GO:0061037">
\r
2118 <desc>negative regulation of cartilage development</desc>
\r
2120 <annotation ref="GO:0061072">
\r
2121 <desc>iris morphogenesis</desc>
\r
2123 <annotation ref="GO:0061303">
\r
2124 <desc>cornea development in camera-type eye</desc>
\r
2126 <annotation ref="GO:0071300">
\r
2127 <desc>cellular response to retinoic acid</desc>
\r
2129 <annotation ref="GO:0072498">
\r
2130 <desc>embryonic skeletal joint development</desc>
\r
2132 <cross_references>
\r
2133 <accession source="CTD">7483</accession>
\r
2134 <accession source="KEGG">hsa:7483</accession>
\r
2135 <accession source="MIM">602863</accession>
\r
2136 <accession source="NextBio">29314</accession>
\r
2137 <accession source="PharmGKB">PA37379</accession>
\r
2138 </cross_references>
\r
2143 <branch_length>0.12838</branch_length>
\r
2144 <confidence type="bootstrap">100</confidence>
\r
2147 <green>173</green>
\r
2151 <id provider="uniprot">7147</id>
\r
2152 <scientific_name>Diptera</scientific_name>
\r
2153 <rank>order</rank>
\r
2156 <name>Q16S11_AEDAE/58-352</name>
\r
2157 <branch_length>0.08512</branch_length>
\r
2160 <green>173</green>
\r
2164 <id provider="uniprot">7159</id>
\r
2165 <code>AEDAE</code>
\r
2166 <scientific_name>Aedes aegypti</scientific_name>
\r
2167 <common_name>Yellowfever mosquito</common_name>
\r
2168 <synonym>Culex aegypti</synonym>
\r
2169 <rank>species</rank>
\r
2171 <sequence type="protein">
\r
2172 <accession source="uniprot">Q16S11</accession>
\r
2173 <name>Protein Wnt</name>
\r
2174 <mol_seq is_aligned="true">PCRFLSGTR----RQNHQCRRDTG--------LPDAIKEARRLAVTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKV--YRETAFVHALTAAAITYSVARACAEGKM-AKCQCASEK--------------------RPEATRLA---------------------------------------------------------------------WKWGGCSDNI-KHGKRVTRNFLELQP--------ADGDPVAE--MLRHDSEVGIQAVTSTMNDRCKCH---GVSGSCSLKT--------------------CWR-KLGDFNATAAMLRTKYHH-AIRKIPINNKTSRRAI----------------------------------------------------------------------------------------------PKEFRE--REG----------SYDQLFYFETSPTFCSV---------TRGRRC-------------LHP-DN--------------CATLC--CGRGYTTKVVKTIE-KCRCR-FTN---GRCCQIVCDYCEKYEDRYYCK</mol_seq>
\r
2175 <annotation ref="GO:0005578">
\r
2176 <desc>proteinaceous extracellular matrix</desc>
\r
2178 <annotation ref="GO:0007275">
\r
2179 <desc>multicellular organismal development</desc>
\r
2181 <annotation ref="GO:0016055">
\r
2182 <desc>Wnt signaling pathway</desc>
\r
2187 <name>WNT4_DROME/239-539</name>
\r
2188 <branch_length>0.10493</branch_length>
\r
2191 <green>173</green>
\r
2195 <id provider="uniprot">7227</id>
\r
2196 <code>DROME</code>
\r
2197 <scientific_name>Drosophila melanogaster</scientific_name>
\r
2198 <common_name>Fruit fly</common_name>
\r
2199 <rank>species</rank>
\r
2201 <sequence type="protein">
\r
2202 <accession source="uniprot">P40589</accession>
\r
2203 <name>Protein Wnt-4</name>
\r
2204 <gene_name>Wnt4</gene_name>
\r
2205 <mol_seq is_aligned="true">PCRYMPATR----RQNHQCRKETG--------LPGTLSEARRLATTHCEEQFRYDRWNCSIE------------------------------------TRGKRNIFKKL--YKETAFVHALTAAAMTHSIARACAEGRM-TKCSCGPKK--------------------HNREAQD----------------------------------------------------------------------FQWGGCNDNL-KHGKRVTRSFLDLRG--------GDGDEVSE--ILRHDSEVGIEAVSSQMMDKCKCH---GVSGSCSMKT--------------------CWK-KMADFNATATLLRQKYNE-AIRKAPNQRSMRQVSSSRM----------------------------------------------------------------------K-------------------KPKQRRKKPQQS----------QYTTLYYLETSPSYCAV---------TKDRQC-------------LHP-DN--------------CGTLC--CGRGYTTQVVKQVE-KCRCR-FNN---GRCCQLICDYCQRLENKYFCK</mol_seq>
\r
2206 <annotation ref="GO:0001737">
\r
2207 <desc>establishment of imaginal disc-derived wing hair orientation</desc>
\r
2209 <annotation ref="GO:0003407">
\r
2210 <desc>neural retina development</desc>
\r
2212 <annotation ref="GO:0004871">
\r
2213 <desc>signal transducer activity</desc>
\r
2215 <annotation ref="GO:0005109">
\r
2216 <desc>frizzled binding</desc>
\r
2218 <annotation ref="GO:0005515">
\r
2219 <desc>protein binding</desc>
\r
2221 <annotation ref="GO:0005576">
\r
2222 <desc>extracellular region</desc>
\r
2224 <annotation ref="GO:0005578">
\r
2225 <desc>proteinaceous extracellular matrix</desc>
\r
2227 <annotation ref="GO:0005615">
\r
2228 <desc>extracellular space</desc>
\r
2230 <annotation ref="GO:0006928">
\r
2231 <desc>cellular component movement</desc>
\r
2233 <annotation ref="GO:0007435">
\r
2234 <desc>salivary gland morphogenesis</desc>
\r
2236 <annotation ref="GO:0008045">
\r
2237 <desc>motor neuron axon guidance</desc>
\r
2239 <annotation ref="GO:0008585">
\r
2240 <desc>female gonad development</desc>
\r
2242 <annotation ref="GO:0009986">
\r
2243 <desc>cell surface</desc>
\r
2245 <annotation ref="GO:0016055">
\r
2246 <desc>Wnt signaling pathway</desc>
\r
2248 <annotation ref="GO:0016201">
\r
2249 <desc>synaptic target inhibition</desc>
\r
2251 <annotation ref="GO:0016477">
\r
2252 <desc>cell migration</desc>
\r
2254 <annotation ref="GO:0031290">
\r
2255 <desc>retinal ganglion cell axon guidance</desc>
\r
2257 <annotation ref="GO:0035206">
\r
2258 <desc>regulation of hemocyte proliferation</desc>
\r
2260 <annotation ref="GO:0035567">
\r
2261 <desc>non-canonical Wnt signaling pathway</desc>
\r
2263 <annotation ref="GO:0045165">
\r
2264 <desc>cell fate commitment</desc>
\r
2266 <annotation ref="GO:0048041">
\r
2267 <desc>focal adhesion assembly</desc>
\r
2269 <annotation ref="GO:0060071">
\r
2270 <desc>Wnt signaling pathway, planar cell polarity pathway</desc>
\r
2272 <cross_references>
\r
2273 <accession source="CTD">54361</accession>
\r
2274 <accession source="NextBio">786401</accession>
\r
2275 </cross_references>
\r
2281 <name>MOM2_CAEEL/44-362</name>
\r
2282 <branch_length>0.27468</branch_length>
\r
2289 <id provider="uniprot">6239</id>
\r
2290 <code>CAEEL</code>
\r
2291 <scientific_name>Caenorhabditis elegans</scientific_name>
\r
2292 <rank>species</rank>
\r
2294 <sequence type="protein">
\r
2295 <accession source="uniprot">Q10459</accession>
\r
2296 <name>Protein mom-2</name>
\r
2297 <gene_name>mom-2</gene_name>
\r
2298 <mol_seq is_aligned="true">LCKNVPGLT---PQQKRMCHENPN--------IIKYLISGLRSALHTCEYTFQREAWNCTLTL-----------------------------------PGVGTSPLQIA--SRESAYVYAISAAGVSHSLARACSKGLI-DDCGCGETPQGSGS---------VAVSQASSRSSSD----------------------------------------------------------------------FVWAGCSDNV-KFGNTFGRKFVDQYDR------QHATEPRSQ--MNLHNNRVGRRLLVNAMNKECKCH---GVSGSCVTKT--------------------CWK-VMPKFDEFASRLHQKYQL-AKLVTNNDQKLTVRSSP---------------------------------------------------------------------------------------------SAGSSGRSERFARNMDASSKQMRNELIYLDASPNYCAIDVKD--------REC-------------GEN-----------------CPNIC--CGRGWRTTREIVDE-PCHCQ-FV-----WCCEVKCKTCKKLVERNYCL</mol_seq>
\r
2299 <annotation ref="GO:0000132">
\r
2300 <desc>establishment of mitotic spindle orientation</desc>
\r
2302 <annotation ref="GO:0001714">
\r
2303 <desc>endodermal cell fate specification</desc>
\r
2305 <annotation ref="GO:0005109">
\r
2306 <desc>frizzled binding</desc>
\r
2308 <annotation ref="GO:0005576">
\r
2309 <desc>extracellular region</desc>
\r
2311 <annotation ref="GO:0005578">
\r
2312 <desc>proteinaceous extracellular matrix</desc>
\r
2314 <annotation ref="GO:0005615">
\r
2315 <desc>extracellular space</desc>
\r
2317 <annotation ref="GO:0016055">
\r
2318 <desc>Wnt signaling pathway</desc>
\r
2320 <annotation ref="GO:0030010">
\r
2321 <desc>establishment of cell polarity</desc>
\r
2323 <annotation ref="GO:0030182">
\r
2324 <desc>neuron differentiation</desc>
\r
2326 <annotation ref="GO:0030971">
\r
2327 <desc>receptor tyrosine kinase binding</desc>
\r
2329 <annotation ref="GO:0045167">
\r
2330 <desc>asymmetric protein localization involved in cell fate determination</desc>
\r
2332 <annotation ref="GO:0048598">
\r
2333 <desc>embryonic morphogenesis</desc>
\r
2335 <cross_references>
\r
2336 <accession source="CTD">179217</accession>
\r
2337 <accession source="NextBio">904422</accession>
\r
2338 </cross_references>
\r
2344 <name>Q589S1_DUGJA/51-361</name>
\r
2345 <branch_length>0.24548</branch_length>
\r
2348 <green>112</green>
\r
2352 <id provider="uniprot">6161</id>
\r
2353 <code>DUGJA</code>
\r
2354 <scientific_name>Dugesia japonica</scientific_name>
\r
2355 <common_name>Planarian</common_name>
\r
2356 <rank>species</rank>
\r
2358 <sequence type="protein">
\r
2359 <accession source="uniprot">Q589S1</accession>
\r
2360 <name>Protein Wnt</name>
\r
2361 <gene_name>DjwntB</gene_name>
\r
2362 <mol_seq is_aligned="true">ICPMIFEES---SKEKNLCLTYPN--------MMVSIVYGAKLGLVECAQQFKFERWNCTFNESFPN-----------------------------MMTHHLHEMTVRS--VKETAFLFSIWSSGVVYSITNSCSKGDL-KECYCDPQR--------------------HGQDKDGSG-------------------------------------------------------------------DFTWGGCSDHI-KFGMKVSTIFLDNHD-------RKDQTGRSL--MNQHNNRVGRRVVWKTRLKKCKCH---GVSGACSLRT--------------------CWQ-RMNDFRRIGDMLKKLYNK-PQKVSYNPFQKS--------------------------------------------------------------------------------------------------LTFSRNQFRRP----------SKKRLVYIEQSQDYCIQDLTI-GHPGTGGREC-------------NYT-SS---------QHDS-CSELC--CNRGHYAYEMVVEE-NCDCK-FF-----WCCEVDAKYAGER---YSCI</mol_seq>
\r
2363 <annotation ref="GO:0005578">
\r
2364 <desc>proteinaceous extracellular matrix</desc>
\r
2366 <annotation ref="GO:0007275">
\r
2367 <desc>multicellular organismal development</desc>
\r
2369 <annotation ref="GO:0016055">
\r
2370 <desc>Wnt signaling pathway</desc>
\r
2377 <branch_length>0.00547</branch_length>
\r
2378 <confidence type="bootstrap">3</confidence>
\r
2380 <branch_length>0.006</branch_length>
\r
2381 <confidence type="bootstrap">7</confidence>
\r
2383 <branch_length>0.03522</branch_length>
\r
2384 <confidence type="bootstrap">55</confidence>
\r
2386 <branch_length>0.07607</branch_length>
\r
2387 <confidence type="bootstrap">100</confidence>
\r
2389 <branch_length>0.07054</branch_length>
\r
2390 <confidence type="bootstrap">100</confidence>
\r
2397 <id provider="uniprot">117571</id>
\r
2398 <scientific_name>Euteleostomi</scientific_name>
\r
2401 <branch_length>0.03271</branch_length>
\r
2402 <confidence type="bootstrap">96</confidence>
\r
2409 <branch_length>0.01268</branch_length>
\r
2410 <confidence type="bootstrap">86</confidence>
\r
2417 <branch_length>0.12585</branch_length>
\r
2418 <confidence type="bootstrap">100</confidence>
\r
2425 <id provider="uniprot">32443</id>
\r
2426 <scientific_name>Teleostei</scientific_name>
\r
2427 <rank>infraclass</rank>
\r
2430 <name>WN10B_DANRE/47-427</name>
\r
2431 <branch_length>0.07866</branch_length>
\r
2438 <id provider="uniprot">7955</id>
\r
2439 <code>DANRE</code>
\r
2440 <scientific_name>Danio rerio</scientific_name>
\r
2441 <common_name>Zebrafish</common_name>
\r
2442 <synonym>Brachydanio rerio</synonym>
\r
2443 <rank>species</rank>
\r
2445 <sequence type="protein">
\r
2446 <accession source="uniprot">Q801F7</accession>
\r
2447 <name>Protein Wnt-10b</name>
\r
2448 <gene_name>wnt10b</gene_name>
\r
2449 <mol_seq is_aligned="true">VCLRLAGLT---KKQMRLCVRSPD--------VTASALQGIQVAIHECQHQLRDQRWNCSSLENHG-------------------------------KLPHQSAILNRG--FRESAFSLSLLAAGVVHSVASACSLGKL-RGCGCEAKR--------------------RLDDDKIRLKLTQLQLQTFQRSGVSLAGAGENTPELSS--------LHGSLPANLHSSHPMSLLKPLPDEVTMLQDTWEWGGCSHDI-RFGVRFSRDWLDSRG--------SPRDIHAR--TRIHNNRVGRQVVTDNMRRKCKCH---GTSGSCQFKT--------------------CWY-VSPEFRLVGSLLREKFLT-AIFINSQNKNNGVFNSRTGGST----------------------------------------------------------------GSDP-L----------------RGQRRRS----------------ISRELVYFEKSPDFCDREPAV-DSLGTQGRIC-------------NKS-SP---------GMDG-CGSLC--CGRGHNILKQARSE-RCHCR-FH-----WCCYVLCEECKVTEWVNVCK</mol_seq>
\r
2450 <annotation ref="GO:0005109">
\r
2451 <desc>frizzled binding</desc>
\r
2453 <annotation ref="GO:0005578">
\r
2454 <desc>proteinaceous extracellular matrix</desc>
\r
2456 <annotation ref="GO:0005615">
\r
2457 <desc>extracellular space</desc>
\r
2459 <annotation ref="GO:0016055">
\r
2460 <desc>Wnt signaling pathway</desc>
\r
2462 <annotation ref="GO:0030182">
\r
2463 <desc>neuron differentiation</desc>
\r
2465 <annotation ref="GO:0030917">
\r
2466 <desc>midbrain-hindbrain boundary development</desc>
\r
2468 <annotation ref="GO:0045165">
\r
2469 <desc>cell fate commitment</desc>
\r
2471 <annotation ref="GO:0060070">
\r
2472 <desc>canonical Wnt signaling pathway</desc>
\r
2474 <cross_references>
\r
2475 <accession source="CTD">7480</accession>
\r
2476 <accession source="KEGG">dre:30308</accession>
\r
2477 <accession source="NextBio">20806749</accession>
\r
2478 </cross_references>
\r
2482 <name>Q4RW24_TETNG/23-401</name>
\r
2483 <branch_length>0.06698</branch_length>
\r
2490 <id provider="uniprot">99883</id>
\r
2491 <code>TETNG</code>
\r
2492 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
2493 <common_name>Spotted green pufferfish</common_name>
\r
2494 <synonym>Chelonodon nigroviridis</synonym>
\r
2495 <rank>species</rank>
\r
2497 <sequence type="protein">
\r
2498 <accession source="uniprot">Q4RW24</accession>
\r
2499 <name>Protein Wnt</name>
\r
2500 <mol_seq is_aligned="true">VCLKLAGLS---KRQMRMCVRSPD--------ATASALQGIQVAIHECQYQLRDQRWNCSSLEGLG-------------------------------KVPHHNTILNRG--FRESAFSLAMLAAGVAHSVASACSMGKL-RGCGCEAKR--------------------RQDDDKIRLKLTQLQLQTLQKGGVGFGVTQSLSSELSG--------HHRDLPTNLRSTHPSGLLKPLPDDLSSLQETWEWGGCSHDV-RFGDRFSRDWLNSRG--------SPRDIHAR--MKIHNNRVGRQVVTDNMKRKCKCH---GTSGSCQFKT--------------------CWH-VSPEFRLVGSLLKEKFLS-AILVNSQNKNNGVFNSRNGVS------------------------------------------------------------------GST-G----------------GPGRRRS----------------MSRELVYFEKSPDFCERDSSV-DSAGTQGRIC-------------NKT-SH---------GTDS-CGSLC--CGRGHNILKKTQSE-RCNCR-FH-----WCCYVLCEECHLTEWVNVCK</mol_seq>
\r
2501 <annotation ref="GO:0005578">
\r
2502 <desc>proteinaceous extracellular matrix</desc>
\r
2504 <annotation ref="GO:0007275">
\r
2505 <desc>multicellular organismal development</desc>
\r
2507 <annotation ref="GO:0016055">
\r
2508 <desc>Wnt signaling pathway</desc>
\r
2514 <name>A0JMB0_XENTR/45-388</name>
\r
2515 <branch_length>0.08158</branch_length>
\r
2522 <id provider="uniprot">8364</id>
\r
2523 <code>XENTR</code>
\r
2524 <scientific_name>Xenopus tropicalis</scientific_name>
\r
2525 <common_name>Western clawed frog</common_name>
\r
2526 <synonym>Silurana tropicalis</synonym>
\r
2527 <rank>species</rank>
\r
2529 <sequence type="protein">
\r
2530 <accession source="uniprot">A0JMB0</accession>
\r
2531 <name>Protein Wnt</name>
\r
2532 <gene_name>wnt10b</gene_name>
\r
2533 <mol_seq is_aligned="true">VCLTLPGLS---KRQMGLCVRNPD--------VTASALQGIQIAIHECQHQLKGQRWNCSTLETMG-------------------------------KMPHDSAILKRG--FRESAFAFSLLAAGVMHSVATACSLGKL-QGCGCEWKR--------------------RGTEEKIRLKLNQLQLQALSKVKGLP---------------------------------RDLTPLLRETPEPSPQDTWEWGGCKHEL-EFGEKFSRDFLDSRE--------SPRDIHAR--MRIHNNRVGRQAVTENMKRRCKCH---GTSGSCQFKT--------------------CWH-VTPDFRAVGTLMRDKLQR-AVFVNSRNKNSGAFHPR---------------------------------------------------------------------------------------------LNKKR----------------LAKELVYFEKSPDFCEKDPRV-DSPGTQGRVC-------------NKT-SQ---------QMDN-CASLC--CGRGHNILMQTRRE-RCNCR-FH-----WCCYVMCEECRVTQLVNVCK</mol_seq>
\r
2534 <annotation ref="GO:0005578">
\r
2535 <desc>proteinaceous extracellular matrix</desc>
\r
2537 <annotation ref="GO:0007275">
\r
2538 <desc>multicellular organismal development</desc>
\r
2540 <annotation ref="GO:0016055">
\r
2541 <desc>Wnt signaling pathway</desc>
\r
2543 <cross_references>
\r
2544 <accession source="CTD">7480</accession>
\r
2545 <accession source="KEGG">xtr:780228</accession>
\r
2546 </cross_references>
\r
2551 <name>WN10B_HUMAN/47-389</name>
\r
2552 <branch_length>0.08989</branch_length>
\r
2559 <id provider="uniprot">9606</id>
\r
2560 <code>HUMAN</code>
\r
2561 <scientific_name>Homo sapiens</scientific_name>
\r
2562 <common_name>Human</common_name>
\r
2563 <rank>species</rank>
\r
2565 <sequence type="protein">
\r
2566 <accession source="uniprot">O00744</accession>
\r
2567 <name>Protein Wnt-10b</name>
\r
2568 <gene_name>WNT10B</gene_name>
\r
2569 <mol_seq is_aligned="true">VCLTLSGLS---KRQLGLCLRNPD--------VTASALQGLHIAVHECQHQLRDQRWNCSALEGGG-------------------------------RLPHHSAILKRG--FRESAFSFSMLAAGVMHAVATACSLGKL-VSCGCGWKG--------------------SGEQDRLRAKLLQLQALSRGKSFPH----------------------------------SLPSPGPGSSPSPGPQDTWEWGGCNHDM-DFGEKFSRDFLDSRE--------APRDIQAR--MRIHNNRVGRQVVTENLKRKCKCH---GTSGSCQFKT--------------------CWR-AAPEFRAVGAALRERLGR-AIFIDTHNRNSGAFQPR---------------------------------------------------------------------------------------------LRPRR----------------LSGELVYFEKSPDFCERDPTM-GSPGTRGRAC-------------NKT-SR---------LLDG-CGSLC--CGRGHNVLRQTRVE-RCHCR-FH-----WCCYVLCDECKVTEWVNVCK</mol_seq>
\r
2570 <annotation ref="GO:0000086">
\r
2571 <desc>G2/M transition of mitotic cell cycle</desc>
\r
2573 <annotation ref="GO:0000122">
\r
2574 <desc>negative regulation of transcription from RNA polymerase II promoter</desc>
\r
2576 <annotation ref="GO:0002062">
\r
2577 <desc>chondrocyte differentiation</desc>
\r
2579 <annotation ref="GO:0005109">
\r
2580 <desc>frizzled binding</desc>
\r
2582 <annotation ref="GO:0005576">
\r
2583 <desc>extracellular region</desc>
\r
2585 <annotation ref="GO:0005578">
\r
2586 <desc>proteinaceous extracellular matrix</desc>
\r
2588 <annotation ref="GO:0005615">
\r
2589 <desc>extracellular space</desc>
\r
2591 <annotation ref="GO:0006629">
\r
2592 <desc>lipid metabolic process</desc>
\r
2594 <annotation ref="GO:0007050">
\r
2595 <desc>cell cycle arrest</desc>
\r
2597 <annotation ref="GO:0007224">
\r
2598 <desc>smoothened signaling pathway</desc>
\r
2600 <annotation ref="GO:0008284">
\r
2601 <desc>positive regulation of cell proliferation</desc>
\r
2603 <annotation ref="GO:0010971">
\r
2604 <desc>positive regulation of G2/M transition of mitotic cell cycle</desc>
\r
2606 <annotation ref="GO:0014835">
\r
2607 <desc>myoblast differentiation involved in skeletal muscle regeneration</desc>
\r
2609 <annotation ref="GO:0016055">
\r
2610 <desc>Wnt signaling pathway</desc>
\r
2612 <annotation ref="GO:0030182">
\r
2613 <desc>neuron differentiation</desc>
\r
2615 <annotation ref="GO:0030501">
\r
2616 <desc>positive regulation of bone mineralization</desc>
\r
2618 <annotation ref="GO:0030858">
\r
2619 <desc>positive regulation of epithelial cell differentiation</desc>
\r
2621 <annotation ref="GO:0032434">
\r
2622 <desc>regulation of proteasomal ubiquitin-dependent protein catabolic process</desc>
\r
2624 <annotation ref="GO:0043065">
\r
2625 <desc>positive regulation of apoptotic process</desc>
\r
2627 <annotation ref="GO:0045165">
\r
2628 <desc>cell fate commitment</desc>
\r
2630 <annotation ref="GO:0045599">
\r
2631 <desc>negative regulation of fat cell differentiation</desc>
\r
2633 <annotation ref="GO:0045669">
\r
2634 <desc>positive regulation of osteoblast differentiation</desc>
\r
2636 <annotation ref="GO:0045899">
\r
2637 <desc>positive regulation of RNA polymerase II transcriptional preinitiation complex assembly</desc>
\r
2639 <annotation ref="GO:0048018">
\r
2640 <desc>receptor agonist activity</desc>
\r
2642 <annotation ref="GO:0048641">
\r
2643 <desc>regulation of skeletal muscle tissue development</desc>
\r
2645 <annotation ref="GO:0048741">
\r
2646 <desc>skeletal muscle fiber development</desc>
\r
2648 <annotation ref="GO:0050680">
\r
2649 <desc>negative regulation of epithelial cell proliferation</desc>
\r
2651 <annotation ref="GO:0050821">
\r
2652 <desc>protein stabilization</desc>
\r
2654 <annotation ref="GO:0050909">
\r
2655 <desc>sensory perception of taste</desc>
\r
2657 <annotation ref="GO:0051091">
\r
2658 <desc>positive regulation of sequence-specific DNA binding transcription factor activity</desc>
\r
2660 <annotation ref="GO:0051885">
\r
2661 <desc>positive regulation of anagen</desc>
\r
2663 <annotation ref="GO:0060070">
\r
2664 <desc>canonical Wnt signaling pathway</desc>
\r
2666 <annotation ref="GO:0060346">
\r
2667 <desc>bone trabecula formation</desc>
\r
2669 <annotation ref="GO:0061196">
\r
2670 <desc>fungiform papilla development</desc>
\r
2672 <annotation ref="GO:0071300">
\r
2673 <desc>cellular response to retinoic acid</desc>
\r
2675 <annotation ref="GO:0071320">
\r
2676 <desc>cellular response to cAMP</desc>
\r
2678 <annotation ref="GO:0071374">
\r
2679 <desc>cellular response to parathyroid hormone stimulus</desc>
\r
2681 <annotation ref="GO:0071425">
\r
2682 <desc>hematopoietic stem cell proliferation</desc>
\r
2684 <annotation ref="GO:0071464">
\r
2685 <desc>cellular response to hydrostatic pressure</desc>
\r
2687 <annotation ref="GO:0090263">
\r
2688 <desc>positive regulation of canonical Wnt signaling pathway</desc>
\r
2690 <cross_references>
\r
2691 <accession source="CTD">7480</accession>
\r
2692 <accession source="KEGG">hsa:7480</accession>
\r
2693 <accession source="MIM">225300</accession>
\r
2694 <accession source="MIM">601906</accession>
\r
2695 <accession source="NextBio">29300</accession>
\r
2696 <accession source="Orphanet" comment="Split hand-split foot malformation">2440</accession>
\r
2697 <accession source="PharmGKB">PA37377</accession>
\r
2698 </cross_references>
\r
2703 <branch_length>0.05315</branch_length>
\r
2704 <confidence type="bootstrap">98</confidence>
\r
2711 <name>Q53S44_HUMAN/60-417</name>
\r
2712 <branch_length>0.09396</branch_length>
\r
2719 <id provider="uniprot">9606</id>
\r
2720 <code>HUMAN</code>
\r
2721 <scientific_name>Homo sapiens</scientific_name>
\r
2722 <common_name>Human</common_name>
\r
2723 <rank>species</rank>
\r
2725 <sequence type="protein">
\r
2726 <accession source="uniprot">Q9GZT5</accession>
\r
2727 <name>Protein Wnt-10a</name>
\r
2728 <gene_name>WNT10A</gene_name>
\r
2729 <mol_seq is_aligned="true">VCLTLPGLS---RRQMEVCVRHPD--------VAASAIQGIQIAIHECQHQFRDQRWNCSSLETRN-------------------------------KIPYESPIFSRG--FRESAFAYAIAAAGVVHAVSNACALGKL-KACGCDASR--------------------RGDEEAFRRKLHRLQLDALQRGKGLS--------------------------------HGVPEHPALPTASPGLQDSWEWGGCSPDM-GFGERFSKDFLDSRE--------PHRDIHAR--MRLHNNRVGRQAVMENMRRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRTVGALLRSRFHR-ATLIRPHNRNGGQLEPGPAGAP---------------------------------------------------------------SPAPG-A----------------PGPRRRA----------------SPADLVYFEKSPDFCEREPRL-DSAGTVGRLC-------------NKS-SA---------GSDG-CGSMC--CGRGHNILRQTRSE-RCHCR-FH-----WCCFVVCEECRITEWVSVCK</mol_seq>
\r
2730 <annotation ref="GO:0001942">
\r
2731 <desc>hair follicle development</desc>
\r
2733 <annotation ref="GO:0005109">
\r
2734 <desc>frizzled binding</desc>
\r
2736 <annotation ref="GO:0005576">
\r
2737 <desc>extracellular region</desc>
\r
2739 <annotation ref="GO:0005578">
\r
2740 <desc>proteinaceous extracellular matrix</desc>
\r
2742 <annotation ref="GO:0005615">
\r
2743 <desc>extracellular space</desc>
\r
2745 <annotation ref="GO:0010628">
\r
2746 <desc>positive regulation of gene expression</desc>
\r
2748 <annotation ref="GO:0014033">
\r
2749 <desc>neural crest cell differentiation</desc>
\r
2751 <annotation ref="GO:0016055">
\r
2752 <desc>Wnt signaling pathway</desc>
\r
2754 <annotation ref="GO:0030182">
\r
2755 <desc>neuron differentiation</desc>
\r
2757 <annotation ref="GO:0031069">
\r
2758 <desc>hair follicle morphogenesis</desc>
\r
2760 <annotation ref="GO:0042476">
\r
2761 <desc>odontogenesis</desc>
\r
2763 <annotation ref="GO:0042487">
\r
2764 <desc>regulation of odontogenesis of dentin-containing tooth</desc>
\r
2766 <annotation ref="GO:0043586">
\r
2767 <desc>tongue development</desc>
\r
2769 <annotation ref="GO:0043588">
\r
2770 <desc>skin development</desc>
\r
2772 <annotation ref="GO:0045165">
\r
2773 <desc>cell fate commitment</desc>
\r
2775 <annotation ref="GO:0048730">
\r
2776 <desc>epidermis morphogenesis</desc>
\r
2778 <annotation ref="GO:0048733">
\r
2779 <desc>sebaceous gland development</desc>
\r
2781 <annotation ref="GO:0071560">
\r
2782 <desc>cellular response to transforming growth factor beta stimulus</desc>
\r
2784 <cross_references>
\r
2785 <accession source="CTD">80326</accession>
\r
2786 <accession source="KEGG">hsa:80326</accession>
\r
2787 <accession source="MIM">150400</accession>
\r
2788 <accession source="MIM">224750</accession>
\r
2789 <accession source="MIM">257980</accession>
\r
2790 <accession source="MIM">606268</accession>
\r
2791 <accession source="NextBio">70863</accession>
\r
2792 <accession source="Orphanet" comment="Hypodontia">2227</accession>
\r
2793 <accession source="Orphanet" comment="Autosomal recessive hypohidrotic ectodermal dysplasia">248</accession>
\r
2794 <accession source="Orphanet" comment="Odonto-onycho-dermal dysplasia">2721</accession>
\r
2795 <accession source="Orphanet" comment="Schopf-Schulz-Passarge syndrome">50944</accession>
\r
2796 <accession source="Orphanet" comment="Oligodontia">99798</accession>
\r
2797 <accession source="PharmGKB">PA37817</accession>
\r
2798 </cross_references>
\r
2802 <name>A4ZGN7_XENLA/44-389</name>
\r
2803 <branch_length>0.05956</branch_length>
\r
2810 <id provider="uniprot">8355</id>
\r
2811 <code>XENLA</code>
\r
2812 <scientific_name>Xenopus laevis</scientific_name>
\r
2813 <common_name>African clawed frog</common_name>
\r
2814 <rank>species</rank>
\r
2816 <sequence type="protein">
\r
2817 <accession source="uniprot">A4ZGN7</accession>
\r
2818 <name>Protein Wnt</name>
\r
2819 <gene_name>wnt10a</gene_name>
\r
2820 <mol_seq is_aligned="true">VCLTVPGLT---RRQMEVCMRHPD--------VAASAIQGIQIAIHECQYQFQDHRWNCSSLETKN-------------------------------KIPYDSAVFSRG--FRESAYVYAIAAAGVVHAVSNACSMGKL-KSCGCDEKR--------------------RGDEEAFKAKLHRLQLEAMNRGKGM----------------------------------VHGVMEHLPADPPGPQDSWEWGGCSPDV-EYGERFSKEFLDSRE--------LFRDIHAR--MRLHNNRVGRQVVTDNMKRKCKCH---GTSGSCQLKT--------------------CWQ-VTPEFRIIGSLLKDRFYG-ATLIKPHNRNTGQLEQAP-----------------------------------------------------------------------V-------------------PFRRRA----------------SINDLVYFEKSPDFCEQELNL-DSAGTQGRIC-------------NKT-SP---------GLDN-CESLC--CGRGHNILRQTRSE-RCNCK-FH-----WCCYVVCEECRITEWVSVCK</mol_seq>
\r
2821 <annotation ref="GO:0005578">
\r
2822 <desc>proteinaceous extracellular matrix</desc>
\r
2824 <annotation ref="GO:0007275">
\r
2825 <desc>multicellular organismal development</desc>
\r
2827 <annotation ref="GO:0016055">
\r
2828 <desc>Wnt signaling pathway</desc>
\r
2830 <cross_references>
\r
2831 <accession source="CTD">80326</accession>
\r
2832 <accession source="KEGG">xla:100049784</accession>
\r
2833 </cross_references>
\r
2839 <branch_length>0.19929</branch_length>
\r
2840 <confidence type="bootstrap">100</confidence>
\r
2843 <green>173</green>
\r
2847 <id provider="uniprot">7147</id>
\r
2848 <scientific_name>Diptera</scientific_name>
\r
2849 <rank>order</rank>
\r
2852 <name>Q17NQ1_AEDAE/7-386</name>
\r
2853 <branch_length>0.09394</branch_length>
\r
2856 <green>173</green>
\r
2860 <id provider="uniprot">7159</id>
\r
2861 <code>AEDAE</code>
\r
2862 <scientific_name>Aedes aegypti</scientific_name>
\r
2863 <common_name>Yellowfever mosquito</common_name>
\r
2864 <synonym>Culex aegypti</synonym>
\r
2865 <rank>species</rank>
\r
2867 <sequence type="protein">
\r
2868 <accession source="uniprot">Q17NQ1</accession>
\r
2869 <name>Protein Wnt</name>
\r
2870 <mol_seq is_aligned="true">TCRTVPGLT---REQLELCYRASD--------VTAAAIEGLELGVRECQHQFQWHRWNCSSLSTKS-------------------------------RNPHTSSMLKRG--YRESAFAYAVAAAGVTHSVARACAQGRL-ISCGCDPSVNRKGM---------TKSLRESLEKEKLRFLDAINENSILVD-------------------------------------------DSLKKLKTKQASRWKWGGCSHNM-AFGVEFSELFLDTRE--------KGGDIQSQ--INLHNNHAGRRAVSNNMQVRCKCH---GMSGSCQLKT--------------------CWK-SAPDFRVVGKVLKQQYRR-AVLVDQSNLGNGPPMIVYHKPKKRKHVNNV-----------------------------------------------RPPRRTKDKGQQQ-QQRH----------LIPISRANRK----------------MENALFYYQRSPNFCERDQVS-DIPGTVGRRC-------------NRT-SV---------GSDG-CASMC--CGRGYNLIREKRVD-RCNCK-FH-----WCCYVECDDCEIEEWISVCN</mol_seq>
\r
2871 <annotation ref="GO:0005578">
\r
2872 <desc>proteinaceous extracellular matrix</desc>
\r
2874 <annotation ref="GO:0007275">
\r
2875 <desc>multicellular organismal development</desc>
\r
2877 <annotation ref="GO:0016055">
\r
2878 <desc>Wnt signaling pathway</desc>
\r
2883 <name>Q9VM25_DROME/24-432</name>
\r
2884 <branch_length>0.22204</branch_length>
\r
2887 <green>173</green>
\r
2891 <id provider="uniprot">7227</id>
\r
2892 <code>DROME</code>
\r
2893 <scientific_name>Drosophila melanogaster</scientific_name>
\r
2894 <common_name>Fruit fly</common_name>
\r
2895 <rank>species</rank>
\r
2897 <sequence type="protein">
\r
2898 <accession source="uniprot">Q9VM25</accession>
\r
2899 <name>Protein Wnt</name>
\r
2900 <gene_name>Wnt10</gene_name>
\r
2901 <mol_seq is_aligned="true">TCRSVPGLT---KDQVELCYKASD--------VTAAALEGLDMAIRECQIQFQWHRWNCSSLSTKS-------------------------------RNPHASSLLKKG--YRESAFAFAISAAGVAHSVARACSQGRL-MSCGCDPTINRKTL---------NKNLRQSLDKEKKQFLQYLETNQILTP------------------------------------------EEEKKYERSKIASRWKWGGCSHNM-DFGVEYSKLFLDCRE--------KAGDIQSK--INLHNNHAGRIAVSNNMEFRCKCH---GMSGSCQLKT--------------------CWK-SAPDFHIVGKVLKHQFRK-AILVDQSNLGNGEPVVVLKRARNKKSNGGSGSGSTSPDLDS--------------------------TDASGGHDDGGTGDSETRRHDEL-GVERGTRQ---PSADKNAARMARK----------------LETSLFYYQRSPNFCERDLGA-DIQGTVGRKC-------------NRN-TT---------TSDG-CTSLC--CGRGHSQVIQRRAE-RCHCK-FQ-----WCCNVECEECHVEEWISICN</mol_seq>
\r
2902 <annotation ref="GO:0005109">
\r
2903 <desc>frizzled binding</desc>
\r
2905 <annotation ref="GO:0005578">
\r
2906 <desc>proteinaceous extracellular matrix</desc>
\r
2908 <annotation ref="GO:0005615">
\r
2909 <desc>extracellular space</desc>
\r
2911 <annotation ref="GO:0016055">
\r
2912 <desc>Wnt signaling pathway</desc>
\r
2914 <annotation ref="GO:0030182">
\r
2915 <desc>neuron differentiation</desc>
\r
2917 <annotation ref="GO:0045165">
\r
2918 <desc>cell fate commitment</desc>
\r
2920 <cross_references>
\r
2921 <accession source="CTD">34011</accession>
\r
2922 <accession source="NextBio">786423</accession>
\r
2923 </cross_references>
\r
2929 <name>Q5J2D3_NEMVE/42-349</name>
\r
2930 <branch_length>0.16933</branch_length>
\r
2933 <green>132</green>
\r
2937 <id provider="uniprot">45351</id>
\r
2938 <code>NEMVE</code>
\r
2939 <scientific_name>Nematostella vectensis</scientific_name>
\r
2940 <common_name>Starlet sea anemone</common_name>
\r
2941 <rank>species</rank>
\r
2943 <sequence type="protein">
\r
2944 <accession source="uniprot">Q5J2D3</accession>
\r
2945 <name>Protein Wnt</name>
\r
2946 <mol_seq is_aligned="true">VCKNTPSLS---KEQLKMCRRLPD--------VVASALQGMQYAIHECLAQFRYRRWNCSSLEMKN-------------------------------RNPLANPLLSRG--FRETAFVHAILSAGMTSSVARACSMGKL-AKCGCDESL--------------------RGRGTG-----------------------------------------------------------------------WEWGGCGDNI-DYGIETSAKFLDSRE--------KGRDLHSM--MNMHNNMVGRTTLSENAKTKCKCH---GMCGSCSVKT--------------------CWK-TVPDIREIGDRLMEKYDH-ATTIGMGNGRLRLHLTRR-------------------------------------------------------------------------------------------KARRSS----------------VGRALVYYEDSPNYCIENKEL-GIFGTRGRIC-------------SPE-SL---------DTDN-CQNLC--CERGYTTKKLQVTK-RCRCH-FS-----WWCYLICDTCRETSTVSICS</mol_seq>
\r
2947 <annotation ref="GO:0005578">
\r
2948 <desc>proteinaceous extracellular matrix</desc>
\r
2950 <annotation ref="GO:0007275">
\r
2951 <desc>multicellular organismal development</desc>
\r
2953 <annotation ref="GO:0016055">
\r
2954 <desc>Wnt signaling pathway</desc>
\r
2960 <branch_length>0.02092</branch_length>
\r
2961 <confidence type="bootstrap">12</confidence>
\r
2963 <branch_length>0.05896</branch_length>
\r
2964 <confidence type="bootstrap">74</confidence>
\r
2966 <id provider="uniprot">1206794</id>
\r
2967 <scientific_name>Ecdysozoa</scientific_name>
\r
2970 <name>Q9VM26_DROME/49-435</name>
\r
2971 <branch_length>0.37993</branch_length>
\r
2974 <green>173</green>
\r
2978 <id provider="uniprot">7227</id>
\r
2979 <code>DROME</code>
\r
2980 <scientific_name>Drosophila melanogaster</scientific_name>
\r
2981 <common_name>Fruit fly</common_name>
\r
2982 <rank>species</rank>
\r
2984 <sequence type="protein">
\r
2985 <accession source="uniprot">Q9VM26</accession>
\r
2986 <name>Protein Wnt</name>
\r
2987 <gene_name>Wnt6</gene_name>
\r
2988 <mol_seq is_aligned="true">MCKKTRRLR---GKLAEICRHDSA-------LLKEIIINGINLGFRECEFQFRNRRWNCTVLR-----------------------------------KSMRK-ILMRD--SRETGFVNAITAAGVTYAVTKACTMGQL-VECSCDKAHMRRNG---------GQPQMVTAATAEAALERQQQAAMLRQQMPLQDQHPSQRLSRMNNASTMTDIAPVEHRGGRNRRPGGRRGRRKFWDNIKFPEGQWEWGGCSDNV-NFGLRHSRVFLDAKQR------QRRSDLGTL--VKFHNNNAGRLAIRDAMRLECKCH---GLSGSCTVKT--------------------CWL-KMPPFREVAGRLRDRYDS-ARKVTLRNDGNSFMPE----------------------------------------------------------------------------------------------SPHAR----PA----------NKYQLVFADDSPDFCTPNSKT-GALGTQGREC-------------NVT-SS---------GSDR-CDRLC--CNRGHTRRIVEEQT-NCKCV-FK-----WCCEVTCEKCLEHRAVNTCL</mol_seq>
\r
2989 <annotation ref="GO:0005109">
\r
2990 <desc>frizzled binding</desc>
\r
2992 <annotation ref="GO:0005578">
\r
2993 <desc>proteinaceous extracellular matrix</desc>
\r
2995 <annotation ref="GO:0005615">
\r
2996 <desc>extracellular space</desc>
\r
2998 <annotation ref="GO:0016055">
\r
2999 <desc>Wnt signaling pathway</desc>
\r
3001 <annotation ref="GO:0030182">
\r
3002 <desc>neuron differentiation</desc>
\r
3004 <annotation ref="GO:0044719">
\r
3005 <desc>regulation of imaginal disc-derived wing size</desc>
\r
3007 <annotation ref="GO:0045165">
\r
3008 <desc>cell fate commitment</desc>
\r
3010 <cross_references>
\r
3011 <accession source="CTD">7475</accession>
\r
3012 <accession source="NextBio">786418</accession>
\r
3013 </cross_references>
\r
3017 <name>Q5IWR0_PRIPA/50-417</name>
\r
3018 <branch_length>0.31534</branch_length>
\r
3025 <id provider="uniprot">54126</id>
\r
3026 <code>PRIPA</code>
\r
3027 <scientific_name>Pristionchus pacificus</scientific_name>
\r
3028 <common_name>Parasitic nematode</common_name>
\r
3029 <rank>species</rank>
\r
3031 <sequence type="protein">
\r
3032 <accession source="uniprot">Q5IWR0</accession>
\r
3033 <name>Protein Wnt</name>
\r
3034 <gene_name>wnt</gene_name>
\r
3035 <mol_seq is_aligned="true">LCAHLTGLN---PVQQQICTSHPF--------SIPFVSRGLRDAIYECQQQFKMERWNCSDRYEIMKTP-------------------------YGYFHDILGKTLRTT--TKESSYLAAIASAGIVYAVTKGCNTGNF-SDCGCDSKPALQRH---------LEAIELNPPSAAALTSMHPGGPVPYPPPPGM----------------------------------PSSAYPPMGSNGMTGNGPFSWGGCSDNV-GYGVRYARKFLDEFERQ---EFNRTSNVQHL--VAMHNHFVGREAIVQNVRKHCRCH---GVSGSCEFKT--------------------CWL-QMPKMKDVAELLKKRYDNFAVQVTKRAKKRL--------------------------------------------------------------------------------------------------RRKERSERATP---------IRGNEMAFVVRSPTYCERNDTA-GILGTAGRDC-------------VHD-SL---------NADS-CDLLC--CGRGYNTRIERQVT-QCNCK-FV-----WCCQVKCKECVDDVALHTCK</mol_seq>
\r
3036 <annotation ref="GO:0005578">
\r
3037 <desc>proteinaceous extracellular matrix</desc>
\r
3039 <annotation ref="GO:0007275">
\r
3040 <desc>multicellular organismal development</desc>
\r
3042 <annotation ref="GO:0016055">
\r
3043 <desc>Wnt signaling pathway</desc>
\r
3049 <branch_length>0.08769</branch_length>
\r
3050 <confidence type="bootstrap">100</confidence>
\r
3057 <id provider="uniprot">117571</id>
\r
3058 <scientific_name>Euteleostomi</scientific_name>
\r
3061 <name>WNT6_MOUSE/39-364</name>
\r
3062 <branch_length>0.13199</branch_length>
\r
3069 <id provider="uniprot">10090</id>
\r
3070 <code>MOUSE</code>
\r
3071 <scientific_name>Mus musculus</scientific_name>
\r
3072 <common_name>Mouse</common_name>
\r
3073 <rank>species</rank>
\r
3075 <sequence type="protein">
\r
3076 <accession source="uniprot">P22727</accession>
\r
3077 <name>Protein Wnt-6</name>
\r
3078 <gene_name>Wnt6</gene_name>
\r
3079 <mol_seq is_aligned="true">ICRKARRLA---GRQAELCQAEPE--------VVAELARGARLGVRECQFQFRFRRWNCSSHS-----------------------------------KAFGR-VLQQD--IRETAFVFAITAAGASHAVTQACSMGEL-LQCGCQAPRGRAPPRPSGLLGTPGPPGPTGSPDASAA---------------------------------------------------------------------WEWGGCGDDV-DFGDEKSRLFMDAQHK------RGRGDIRAL--VQLHNNEAGRLAVRSHTRTECKCH---GLSGSCALRT--------------------CWQ-KLPPFREVGARLLERFHG-ASRVMGTNDGKALLPA----------------------------------------------------------------------------------------------VRTLK----PP----------GRADLLYAADSPDFCAPNRRT-GSPGTRGRAC-------------NSS-AP---------DLSG-CDLLC--CGRGHRQESVQLEE-NCLCR-FH-----WCCVVQCHRCRVRKELSLCL</mol_seq>
\r
3080 <annotation ref="GO:0001658">
\r
3081 <desc>branching involved in ureteric bud morphogenesis</desc>
\r
3083 <annotation ref="GO:0005102">
\r
3084 <desc>receptor binding</desc>
\r
3086 <annotation ref="GO:0005109">
\r
3087 <desc>frizzled binding</desc>
\r
3089 <annotation ref="GO:0005578">
\r
3090 <desc>proteinaceous extracellular matrix</desc>
\r
3092 <annotation ref="GO:0005615">
\r
3093 <desc>extracellular space</desc>
\r
3095 <annotation ref="GO:0005788">
\r
3096 <desc>endoplasmic reticulum lumen</desc>
\r
3098 <annotation ref="GO:0007165">
\r
3099 <desc>signal transduction</desc>
\r
3101 <annotation ref="GO:0007267">
\r
3102 <desc>cell-cell signaling</desc>
\r
3104 <annotation ref="GO:0009798">
\r
3105 <desc>axis specification</desc>
\r
3107 <annotation ref="GO:0009887">
\r
3108 <desc>organ morphogenesis</desc>
\r
3110 <annotation ref="GO:0009986">
\r
3111 <desc>cell surface</desc>
\r
3113 <annotation ref="GO:0010628">
\r
3114 <desc>positive regulation of gene expression</desc>
\r
3116 <annotation ref="GO:0016055">
\r
3117 <desc>Wnt signaling pathway</desc>
\r
3119 <annotation ref="GO:0030182">
\r
3120 <desc>neuron differentiation</desc>
\r
3122 <annotation ref="GO:0031012">
\r
3123 <desc>extracellular matrix</desc>
\r
3125 <annotation ref="GO:0042475">
\r
3126 <desc>odontogenesis of dentin-containing tooth</desc>
\r
3128 <annotation ref="GO:0045165">
\r
3129 <desc>cell fate commitment</desc>
\r
3131 <annotation ref="GO:0045893">
\r
3132 <desc>positive regulation of transcription, DNA-templated</desc>
\r
3134 <annotation ref="GO:0060684">
\r
3135 <desc>epithelial-mesenchymal cell signaling</desc>
\r
3137 <annotation ref="GO:0070172">
\r
3138 <desc>positive regulation of tooth mineralization</desc>
\r
3140 <annotation ref="GO:0072079">
\r
3141 <desc>nephron tubule formation</desc>
\r
3143 <annotation ref="GO:0072080">
\r
3144 <desc>nephron tubule development</desc>
\r
3146 <cross_references>
\r
3147 <accession source="CTD">7475</accession>
\r
3148 <accession source="KEGG">mmu:22420</accession>
\r
3149 <accession source="NextBio">302849</accession>
\r
3150 </cross_references>
\r
3154 <name>Q4RNC9_TETNG/40-334</name>
\r
3155 <branch_length>0.07486</branch_length>
\r
3162 <id provider="uniprot">99883</id>
\r
3163 <code>TETNG</code>
\r
3164 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
3165 <common_name>Spotted green pufferfish</common_name>
\r
3166 <synonym>Chelonodon nigroviridis</synonym>
\r
3167 <rank>species</rank>
\r
3169 <sequence type="protein">
\r
3170 <accession source="uniprot">Q4RNC9</accession>
\r
3171 <name>Protein Wnt</name>
\r
3172 <mol_seq is_aligned="true">ICRKAKRLA---GKQAELCQTQPE--------IVREVAKGARLGVRECQYQFRYRRWNCTSHN-----------------------------------KYFGK-ILQQD--IRETAFVYAITAAGVTHAVTQACSMGDR-PQCGFK----------------------------------------------------------------------------------------------------WEWGGCVDDV-EFGYEKSKQFMDAKRR------RGKSDIRAL--IDLHNNEAGRLAVKLYMRTECKCH---GLSGSCTLRT--------------------CWR-KMPHFREVGDRLLERFNG-AFKVMGSNDGKTLIPV----------------------------------------------------------------------------------------------GQNIK----PP----------DKQDLIYSDDSPDFCLANRKT-GSLGTRGRTC-------------NST-AM---------DISG-CDLLC--CERGYQEETVVFEE-NCLCH-FH-----WCCVVQCKKCFVRKELSLCH</mol_seq>
\r
3173 <annotation ref="GO:0005578">
\r
3174 <desc>proteinaceous extracellular matrix</desc>
\r
3176 <annotation ref="GO:0007275">
\r
3177 <desc>multicellular organismal development</desc>
\r
3179 <annotation ref="GO:0016055">
\r
3180 <desc>Wnt signaling pathway</desc>
\r
3188 <branch_length>0.01935</branch_length>
\r
3189 <confidence type="bootstrap">33</confidence>
\r
3191 <branch_length>0.10758</branch_length>
\r
3192 <confidence type="bootstrap">100</confidence>
\r
3195 <green>112</green>
\r
3199 <id provider="uniprot">6157</id>
\r
3200 <scientific_name>Platyhelminthes</scientific_name>
\r
3201 <rank>phylum</rank>
\r
3204 <name>Q589S7_DUGJA/76-402</name>
\r
3205 <branch_length>0.16397</branch_length>
\r
3208 <green>112</green>
\r
3212 <id provider="uniprot">6161</id>
\r
3213 <code>DUGJA</code>
\r
3214 <scientific_name>Dugesia japonica</scientific_name>
\r
3215 <common_name>Planarian</common_name>
\r
3216 <rank>species</rank>
\r
3218 <sequence type="protein">
\r
3219 <accession source="uniprot">Q589S7</accession>
\r
3220 <name>Protein Wnt</name>
\r
3221 <gene_name>Djwnt-A</gene_name>
\r
3222 <mol_seq is_aligned="true">ICQTFSR------HQRKLCNQHFR--------LMESVVNGFLLGLNECQFQFADQIWNCKGHNMTIGGNRSK-------------------SKPRKKGKTYLDKLVSKG--TPEAAYVLSVISAGVAHQVTKACSKGVH-DSCGCDRTI--------------------YDIPETAT---------------------------------------------------------------------FKWSGCSHNI-HFGAAFTRQFLDITEKT----RVNKRPEKAL--TKLHNNHVGRQAVILKMGKKCKCH---GVSGSCEMKT--------------------CIR-ALPDFRVVGDLLKSRFHK-AMQVHFVDSRLIPRYSPNR----------------------------------------------------------------------M-------------------F---------------------TDNDLIYLLKSPNYCVHNPHI-GSLGTQGRKC-----------------AESALLEKKPGETNGTCEELC--CGRGHKKRTFSRME-QCRCK-FQ-----WCCDVKCDLCKKDVIESVCD</mol_seq>
\r
3223 <annotation ref="GO:0005578">
\r
3224 <desc>proteinaceous extracellular matrix</desc>
\r
3226 <annotation ref="GO:0007275">
\r
3227 <desc>multicellular organismal development</desc>
\r
3229 <annotation ref="GO:0016055">
\r
3230 <desc>Wnt signaling pathway</desc>
\r
3235 <name>A6XBT4_SCHJA/38-436</name>
\r
3236 <branch_length>0.34628</branch_length>
\r
3239 <green>112</green>
\r
3243 <id provider="uniprot">6182</id>
\r
3244 <code>SCHJA</code>
\r
3245 <scientific_name>Schistosoma japonicum</scientific_name>
\r
3246 <common_name>Blood fluke</common_name>
\r
3247 <rank>species</rank>
\r
3249 <sequence type="protein">
\r
3250 <accession source="uniprot">A6XBT4</accession>
\r
3251 <name>Protein Wnt</name>
\r
3252 <mol_seq is_aligned="true">ICDHPNGFL---RRQKKLCRQYLH--------LMESVIRGYFMGLKECEYQFSAHRWNCQGHNLTIQAPTSRKQKRLRYRESELKNDMDNSRRKSVRIQTYLDKLLSKG--TRESAYVLAVTSAGVSHAVTKACSSGLH-DNCGCDRTI--------------------YDHPREPN---------------------------------------------------------------------FEWSGCSDNI-HFGAAFSRQFLDVRERN----RLKRNPKLGL--TNLHNNHVGRHMVINKMEVQCKCH---GVSGSCEMRT--------------------CWR-SLPKFRHLGAQLQERFHE-AIQVTYIQNRLVSMKALEQLSKESNGNALLLS-------------------------------------------HSALLSSVVSGVSSS-DELPA---------SPRINRNAFDTLTRSTSLTTSPLPSPTENDLIYISESPTFCHHDPRY-GSIGTYGRQC-------------DEN-SQ---------GLNS-CNYLC--CGRGFKRQTFVQQE-RCDCK-FQ-----WCCKVVCKTCRKTVVISTCN</mol_seq>
\r
3253 <annotation ref="GO:0005578">
\r
3254 <desc>proteinaceous extracellular matrix</desc>
\r
3256 <annotation ref="GO:0007275">
\r
3257 <desc>multicellular organismal development</desc>
\r
3259 <annotation ref="GO:0016055">
\r
3260 <desc>Wnt signaling pathway</desc>
\r
3266 <branch_length>0.01599</branch_length>
\r
3267 <confidence type="bootstrap">42</confidence>
\r
3269 <name>Q4H305_CIOIN/224-608</name>
\r
3270 <branch_length>0.45291</branch_length>
\r
3277 <id provider="uniprot">7719</id>
\r
3278 <code>CIOIN</code>
\r
3279 <scientific_name>Ciona intestinalis</scientific_name>
\r
3280 <common_name>Transparent sea squirt</common_name>
\r
3281 <synonym>Ascidia intestinalis</synonym>
\r
3282 <rank>species</rank>
\r
3284 <sequence type="protein">
\r
3285 <accession source="uniprot">Q4H305</accession>
\r
3286 <name>Protein Wnt</name>
\r
3287 <gene_name>Ci-Orphan Wnt e</gene_name>
\r
3288 <mol_seq is_aligned="true">ICLWAQQIG---GPQAEMCANEMP--------VVEEIKKGIQRGAYNCAREFRYSRWNCSQTP-----------------------------------KKFYEKALWQT--TKETSYLQAVTSAAMTFAITEACSLGNI-PECGCVNTRGQKRE---------YLRREAQKRNYYINESYLD-----------------------------------------------------------TFVDQFDWEGCDDNV-DFAYRKTRHFLNFTRFI---GRKRKINLRLR--MSAHNYEAGRLAITEKMAEKCKCH---GFSGTCTIRT--------------------CWM-RMPKFDAVRATLRRMYNT-ATKVNLQPGTRRLVIARRPRRPSSRHRNTAS---------------------------------------------RRTNKVKRGLRKNI-PTRFR---------SRNRKAKNPRRRIRLKNRLRRRLYPVASKHLVYHQPSPNFCRRDKRK-GSLGTKGRVC-------------DPTRRE---------GYGS-CQYMC--CGRGYTTEVVEHTM-KCNCT-FI-----YCCTMTCDECINRYTRYVCR</mol_seq>
\r
3289 <annotation ref="GO:0005578">
\r
3290 <desc>proteinaceous extracellular matrix</desc>
\r
3292 <annotation ref="GO:0007275">
\r
3293 <desc>multicellular organismal development</desc>
\r
3295 <annotation ref="GO:0016055">
\r
3296 <desc>Wnt signaling pathway</desc>
\r
3298 <cross_references>
\r
3299 <accession source="KEGG">cin:778723</accession>
\r
3300 </cross_references>
\r
3304 <name>A7RSC1_NEMVE/46-365</name>
\r
3305 <branch_length>0.20497</branch_length>
\r
3308 <green>132</green>
\r
3312 <id provider="uniprot">45351</id>
\r
3313 <code>NEMVE</code>
\r
3314 <scientific_name>Nematostella vectensis</scientific_name>
\r
3315 <common_name>Starlet sea anemone</common_name>
\r
3316 <rank>species</rank>
\r
3318 <sequence type="protein">
\r
3319 <accession source="uniprot">A7RSC1</accession>
\r
3320 <name>Protein Wnt</name>
\r
3321 <mol_seq is_aligned="true">FCSLMPWMK---PHQKQKCLLEPL--------VMPSVQRGVGMALEECPNHFSDHKWNCSGVNTA--------------------------------QVFQERGILKTN--TKESAFVFALTSAGVSFQITKGCSLGNW-EQCGCDTQV--------------------RGRVQTKDE------------------------------------------------------------------ASWEWGGCSENV-GHGDDFSRKFMDPEP--------PRKELEYL--LVKHNNEAGRKALKDNMGKTCKCH---GVSGSCTVKI--------------------CWR-TMPNFSVVAQLLRKKFDQ-ATKVKANDKKTKLQRITRG----------------------------------------------------------------------K-------------------RGKKKRQKGRRP----------SAGDLVFAEKSPKFCIPNPEL-GILGTRGRVC-------------DAN-AK---------DNRG-CKKMC--CNRGYDTFKLSNQV-KCNCE-FI-----WCCKVQCDMCKKDWTEYRCR</mol_seq>
\r
3322 <annotation ref="GO:0005578">
\r
3323 <desc>proteinaceous extracellular matrix</desc>
\r
3325 <annotation ref="GO:0007275">
\r
3326 <desc>multicellular organismal development</desc>
\r
3328 <annotation ref="GO:0016055">
\r
3329 <desc>Wnt signaling pathway</desc>
\r
3338 <branch_length>0.00747</branch_length>
\r
3339 <confidence type="bootstrap">19</confidence>
\r
3341 <branch_length>0.01858</branch_length>
\r
3342 <confidence type="bootstrap">71</confidence>
\r
3344 <branch_length>0.0051</branch_length>
\r
3345 <confidence type="bootstrap">53</confidence>
\r
3347 <branch_length>0.00652</branch_length>
\r
3348 <confidence type="bootstrap">53</confidence>
\r
3350 <branch_length>0.00581</branch_length>
\r
3351 <confidence type="bootstrap">59</confidence>
\r
3353 <branch_length>0.02867</branch_length>
\r
3354 <confidence type="bootstrap">100</confidence>
\r
3356 <branch_length>0.01102</branch_length>
\r
3357 <confidence type="bootstrap">73</confidence>
\r
3359 <branch_length>9.5E-4</branch_length>
\r
3360 <confidence type="bootstrap">32</confidence>
\r
3362 <branch_length>0.0061</branch_length>
\r
3363 <confidence type="bootstrap">43</confidence>
\r
3365 <branch_length>0.03722</branch_length>
\r
3366 <confidence type="bootstrap">100</confidence>
\r
3373 <id provider="uniprot">117571</id>
\r
3374 <scientific_name>Euteleostomi</scientific_name>
\r
3377 <name>A1BPR0_DANRE/62-374</name>
\r
3378 <branch_length>0.06379</branch_length>
\r
3385 <id provider="uniprot">7955</id>
\r
3386 <code>DANRE</code>
\r
3387 <scientific_name>Danio rerio</scientific_name>
\r
3388 <common_name>Zebrafish</common_name>
\r
3389 <synonym>Brachydanio rerio</synonym>
\r
3390 <rank>species</rank>
\r
3392 <sequence type="protein">
\r
3393 <accession source="uniprot">A1BPR0</accession>
\r
3394 <name>Protein Wnt</name>
\r
3395 <gene_name>wnt5a</gene_name>
\r
3396 <mol_seq is_aligned="true">LCSQLSGLS---KGQKKLCQLYQD--------HMQYIGEGAKTGIRECQHQFRHRRWNCSTVDNS---------------------------------TVLGR-VMHIG--SRESAFAFAISAAGVLHAVSRACREGAL-SSCGCSRAS--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNL-NYGYRFSREFVDAREREKTFSKGSAESARQM--MNLHNNEAGRRIVSDLADVSCKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGDVLKEKYDS-AAAMRMNGRGKLVQM-----------------------------------------------------------------------------------------------HSKFS----PP----------SGQDLLYLQPSPDYCIRNSSS-GSLGTQGRLC-------------NKT-SE---------GMDG-CALMC--CGRGYDQYKAELVE-RCHCK-FH-----WCCYVRCKRCSSIVDQYVCK</mol_seq>
\r
3397 <annotation ref="GO:0005578">
\r
3398 <desc>proteinaceous extracellular matrix</desc>
\r
3400 <annotation ref="GO:0007275">
\r
3401 <desc>multicellular organismal development</desc>
\r
3403 <annotation ref="GO:0016055">
\r
3404 <desc>Wnt signaling pathway</desc>
\r
3406 <cross_references>
\r
3407 <accession source="CTD">7474</accession>
\r
3408 <accession source="KEGG">dre:568191</accession>
\r
3409 <accession source="NextBio">20889048</accession>
\r
3410 </cross_references>
\r
3414 <name>Q6DII0_XENTR/48-360</name>
\r
3415 <branch_length>0.05868</branch_length>
\r
3422 <id provider="uniprot">8364</id>
\r
3423 <code>XENTR</code>
\r
3424 <scientific_name>Xenopus tropicalis</scientific_name>
\r
3425 <common_name>Western clawed frog</common_name>
\r
3426 <synonym>Silurana tropicalis</synonym>
\r
3427 <rank>species</rank>
\r
3429 <sequence type="protein">
\r
3430 <accession source="uniprot">Q6DII0</accession>
\r
3431 <name>Protein Wnt</name>
\r
3432 <gene_name>wnt5b</gene_name>
\r
3433 <mol_seq is_aligned="true">LCSQLTGLS---PGQRKLCQLYQD--------HMVYIGEGAKTGIKECQHQFKHRRWNCSTVDNN---------------------------------SVFGR-VMQIG--SREAAFTYAISAAGVVNAISRACREGEL-STCGCSRTP--------------------RPKDLPRD---------------------------------------------------------------------WLWGGCGDNV-EYGYRFAKEFVDAREREKNFPKGSEEQARSL--MNLQNNEAGRRAVYKLADVACKCH---GVSGSCSLKT--------------------CWL-QLADFRKVGEYIKEKYDS-AASMRLNKRNKLEQV-----------------------------------------------------------------------------------------------NQRFN----PP----------TAEDLVYLDPSPDYCLYNETT-GSLGTHGRQC-------------NKT-SE---------GMDG-CELMC--CGRGYDQFKTVQVE-RCHCK-FH-----WCCFVKCKKCTEIVDQYVCK</mol_seq>
\r
3434 <annotation ref="GO:0001525">
\r
3435 <desc>angiogenesis</desc>
\r
3437 <annotation ref="GO:0002062">
\r
3438 <desc>chondrocyte differentiation</desc>
\r
3440 <annotation ref="GO:0002574">
\r
3441 <desc>thrombocyte differentiation</desc>
\r
3443 <annotation ref="GO:0005578">
\r
3444 <desc>proteinaceous extracellular matrix</desc>
\r
3446 <annotation ref="GO:0005622">
\r
3447 <desc>intracellular</desc>
\r
3449 <annotation ref="GO:0007223">
\r
3450 <desc>Wnt signaling pathway, calcium modulating pathway</desc>
\r
3452 <annotation ref="GO:0008591">
\r
3453 <desc>regulation of Wnt signaling pathway, calcium modulating pathway</desc>
\r
3455 <annotation ref="GO:0009826">
\r
3456 <desc>unidimensional cell growth</desc>
\r
3458 <annotation ref="GO:0010172">
\r
3459 <desc>embryonic body morphogenesis</desc>
\r
3461 <annotation ref="GO:0031018">
\r
3462 <desc>endocrine pancreas development</desc>
\r
3464 <annotation ref="GO:0031101">
\r
3465 <desc>fin regeneration</desc>
\r
3467 <annotation ref="GO:0048840">
\r
3468 <desc>otolith development</desc>
\r
3470 <annotation ref="GO:0048884">
\r
3471 <desc>neuromast development</desc>
\r
3473 <annotation ref="GO:0051209">
\r
3474 <desc>release of sequestered calcium ion into cytosol</desc>
\r
3476 <annotation ref="GO:0060028">
\r
3477 <desc>convergent extension involved in axis elongation</desc>
\r
3479 <annotation ref="GO:0060030">
\r
3480 <desc>dorsal convergence</desc>
\r
3482 <annotation ref="GO:0061053">
\r
3483 <desc>somite development</desc>
\r
3485 <cross_references>
\r
3486 <accession source="CTD">81029</accession>
\r
3487 <accession source="KEGG">xtr:448452</accession>
\r
3488 </cross_references>
\r
3493 <name>O96867_STRPU/19-331</name>
\r
3494 <branch_length>0.09595</branch_length>
\r
3501 <id provider="uniprot">7668</id>
\r
3502 <code>STRPU</code>
\r
3503 <scientific_name>Strongylocentrotus purpuratus</scientific_name>
\r
3504 <common_name>Purple sea urchin</common_name>
\r
3505 <rank>species</rank>
\r
3507 <sequence type="protein">
\r
3508 <accession source="uniprot">O96867</accession>
\r
3509 <name>Protein Wnt</name>
\r
3510 <gene_name>spwnt-5</gene_name>
\r
3511 <mol_seq is_aligned="true">LCSELLGLS---PGQQKLCQLYQD--------HMAPIGEGAKMSIDECQNQFTNRRWNCSTVDSN---------------------------------NVFGK-VLSIS--SREAAFTYAITSAGVVNAISRSCREGQL-STCGCGKSP--------------------RPPDIPRD---------------------------------------------------------------------WVWGGCGDNI-DYGFRFAREFVDAREMETNPQRGSFAYDRMK--MNLHNNEAGRKAVYDNAGTECKCH---GVSGSCSLKT--------------------CWL-QLSPFNRVGTILKDKYDG-ATNVRVNKKGRLVNS-----------------------------------------------------------------------------------------------DARFN----KP----------TRDDLVYLQPSPDYCLPDIQT-GSLGTTGREC-------------NKT-SM---------GTDG-CTLMC--CGRGYNSFTKEVVE-RCKCK-FK-----WCCYVKCRKCRTLVDVHVCK</mol_seq>
\r
3512 <annotation ref="GO:0005578">
\r
3513 <desc>proteinaceous extracellular matrix</desc>
\r
3515 <annotation ref="GO:0007275">
\r
3516 <desc>multicellular organismal development</desc>
\r
3518 <annotation ref="GO:0016055">
\r
3519 <desc>Wnt signaling pathway</desc>
\r
3525 <name>Q8WS75_BRAFL/55-370</name>
\r
3526 <branch_length>0.10636</branch_length>
\r
3533 <id provider="uniprot">7739</id>
\r
3534 <code>BRAFL</code>
\r
3535 <scientific_name>Branchiostoma floridae</scientific_name>
\r
3536 <common_name>Florida lancelet</common_name>
\r
3537 <synonym>Amphioxus</synonym>
\r
3538 <rank>species</rank>
\r
3540 <sequence type="protein">
\r
3541 <accession source="uniprot">Q8WS75</accession>
\r
3542 <name>Protein Wnt</name>
\r
3543 <gene_name>Wnt5</gene_name>
\r
3544 <mol_seq is_aligned="true">LCTTLAGLS---SGQRKLCNLYQD--------HMSSVGIGARQGIEECQHQFRDRRWNCTTSDED---------------------------------SVFGR-IVNIG--SREASFTYAIAAAGVVNAVSRACREGEL-TTCGCSRAK--------------------RPKDLNRD---------------------------------------------------------------------WLWGGCGDDV-EYGYYFAREFVDAQEKQIIPTPGSQAHARQL--MNMHNNEAGRKLTFSNARVACKCH---GVSGSCSLKT--------------------CWQ-QLADFRTVGNLLKDKYDG-ANEVKLIKRGKRYRLDRR--------------------------------------------------------------------------------------------NPRFN----VF----------TDEDLVYLNKSPDYCNADPTI-GSLGTHGREC-------------NKT-GL---------GTDG-CNLMC--CGRGYNTFKREKVE-RCNCK-FH-----WCCYVKCKRCRSIKNVYVCK</mol_seq>
\r
3545 <annotation ref="GO:0005578">
\r
3546 <desc>proteinaceous extracellular matrix</desc>
\r
3548 <annotation ref="GO:0007275">
\r
3549 <desc>multicellular organismal development</desc>
\r
3551 <annotation ref="GO:0016055">
\r
3552 <desc>Wnt signaling pathway</desc>
\r
3558 <name>Q75PH7_PARTP/66-378</name>
\r
3559 <branch_length>0.11208</branch_length>
\r
3562 <green>173</green>
\r
3566 <id provider="uniprot">114398</id>
\r
3567 <code>PARTP</code>
\r
3568 <scientific_name>Parasteatoda tepidariorum</scientific_name>
\r
3569 <common_name>House spider</common_name>
\r
3570 <synonym>Achaearanea tepidariorum</synonym>
\r
3571 <rank>species</rank>
\r
3573 <sequence type="protein">
\r
3574 <accession source="uniprot">Q75PH7</accession>
\r
3575 <name>Protein Wnt</name>
\r
3576 <gene_name>wnt5</gene_name>
\r
3577 <mol_seq is_aligned="true">LCSRLSGLS---RGQTKLCYLYQD--------HMAHVARGARLGIHECQWQFKNRRWNCSTVDDS---------------------------------SVFGP-VLNIG--SREAGFAHAVAAAGVVHTVSRGCRDGQL-SNCGCSRAM--------------------RPKNLHRD---------------------------------------------------------------------WIWGGCGDNI-EYGYRFTEGFVDVKEREINHARGSREQGRKL--MNLHNNEAGRRAVIRKVRVTCKCH---GVSGSCSLVT--------------------CWQ-QLAPFREVGDYLKDKYDG-ATEVKINHRGKLQIR-----------------------------------------------------------------------------------------------NPRYN----LP----------TAEDLVYVDESPDYCVPNEET-GSWGTEGRVC-------------NRT-SP---------STDG-CNLMC--CGRGYNTHKTTIKE-RCKCK-FH-----WCCYVECKTCHYVLDIQSCK</mol_seq>
\r
3578 <annotation ref="GO:0005578">
\r
3579 <desc>proteinaceous extracellular matrix</desc>
\r
3581 <annotation ref="GO:0007275">
\r
3582 <desc>multicellular organismal development</desc>
\r
3584 <annotation ref="GO:0016055">
\r
3585 <desc>Wnt signaling pathway</desc>
\r
3591 <name>A2SXV2_9MOLL/64-376</name>
\r
3592 <branch_length>0.12755</branch_length>
\r
3595 <green>122</green>
\r
3599 <id provider="uniprot">6613</id>
\r
3600 <code>9MOLL</code>
\r
3601 <scientific_name>Euprymna scolopes</scientific_name>
\r
3602 <rank>phylum</rank>
\r
3604 <sequence type="protein">
\r
3605 <accession source="uniprot">A2SXV2</accession>
\r
3606 <name>Protein Wnt</name>
\r
3607 <gene_name>Wnt5</gene_name>
\r
3608 <mol_seq is_aligned="true">MCVALKGLS---PGQIRICQLFYD--------HMPSVGRGAQLGIRECQYQFRNRRWNCSTVNDE---------------------------------SVFGP-VMELG--SRETGFTHAVSSAGVVYSVSRACPEXQL-SRCGCSKAP--------------------RPPIHKD----------------------------------------------------------------------WLWGDCGDNI-EHGYRFALGFIDKREKERNYPRFSRGLARML--MNLHNNEAGRRAIYKHATVSCKCH---GVSGSCSLKT--------------------CWQ-SSPDFRSVGNRLKEKYNG-ATKVRFNSRGTRLIRR----------------------------------------------------------------------------------------------DHKFN----KP----------TKEDIIYLDDSPDYCMAKPEA-GVLGTVGREC-------------NWT-SK---------GLGG-CALMC--CGRGYNSFRKKVQE-RCHCK-FE-----WCCEVKCDLCEYFVDVHVCK</mol_seq>
\r
3609 <annotation ref="GO:0005578">
\r
3610 <desc>proteinaceous extracellular matrix</desc>
\r
3612 <annotation ref="GO:0007275">
\r
3613 <desc>multicellular organismal development</desc>
\r
3615 <annotation ref="GO:0016055">
\r
3616 <desc>Wnt signaling pathway</desc>
\r
3622 <branch_length>0.0412</branch_length>
\r
3623 <confidence type="bootstrap">100</confidence>
\r
3630 <id provider="uniprot">7713</id>
\r
3631 <scientific_name>Ascidiacea</scientific_name>
\r
3632 <rank>class</rank>
\r
3635 <branch_length>0.01291</branch_length>
\r
3636 <confidence type="bootstrap">87</confidence>
\r
3643 <name>Q9U6V0_CIOIN/49-360</name>
\r
3644 <branch_length>0.10739</branch_length>
\r
3651 <id provider="uniprot">7719</id>
\r
3652 <code>CIOIN</code>
\r
3653 <scientific_name>Ciona intestinalis</scientific_name>
\r
3654 <common_name>Transparent sea squirt</common_name>
\r
3655 <synonym>Ascidia intestinalis</synonym>
\r
3656 <rank>species</rank>
\r
3658 <sequence type="protein">
\r
3659 <accession source="uniprot">Q9U6V0</accession>
\r
3660 <name>Protein Wnt</name>
\r
3661 <gene_name>wnt5</gene_name>
\r
3662 <mol_seq is_aligned="true">ICGQLEGLS---RNQRALCQRYAN--------HMAHVSEGAGIGINECKWQFRGQRWNCSTVDDS---------------------------------SVFGK-VLKIG--SKETAFTYAISAAGVVVAVARACKNEQL-ENCGCGNKA--------------------RPEGLDAS---------------------------------------------------------------------WRWGGCGDNT-EYAYGFAREFIDARERDNISPKRRKDRERKV--MNMHNNEAGRMVVVRSARPTCKCH---GVSGSCSLKT--------------------CWM-QVPGFREIGDELMRKYIG-GVEVRVTNRGQLRPRR----------------------------------------------------------------------------------------------SNDEV----------------GSTSLVYLDSSPDYCDKNRRT-GVAGTKGREC-------------KKD-SS---------GPEG-CGLLC--CGRGFRTYRVRVVE-KCECK-FQ-----WCCSVKCNLCQRTVKRHICR</mol_seq>
\r
3663 <annotation ref="GO:0005109">
\r
3664 <desc>frizzled binding</desc>
\r
3666 <annotation ref="GO:0005578">
\r
3667 <desc>proteinaceous extracellular matrix</desc>
\r
3669 <annotation ref="GO:0005615">
\r
3670 <desc>extracellular space</desc>
\r
3672 <annotation ref="GO:0016055">
\r
3673 <desc>Wnt signaling pathway</desc>
\r
3675 <annotation ref="GO:0030182">
\r
3676 <desc>neuron differentiation</desc>
\r
3678 <annotation ref="GO:0045165">
\r
3679 <desc>cell fate commitment</desc>
\r
3681 <cross_references>
\r
3682 <accession source="CTD">32838</accession>
\r
3683 <accession source="KEGG">cin:445761</accession>
\r
3684 </cross_references>
\r
3688 <name>Q8T8A8_HALRO/49-371</name>
\r
3689 <branch_length>0.13419</branch_length>
\r
3696 <id provider="uniprot">7729</id>
\r
3697 <code>HALRO</code>
\r
3698 <scientific_name>Halocynthia roretzi</scientific_name>
\r
3699 <common_name>Sea squirt</common_name>
\r
3700 <synonym>Cynthia roretzi</synonym>
\r
3701 <rank>species</rank>
\r
3703 <sequence type="protein">
\r
3704 <accession source="uniprot">Q8T8A8</accession>
\r
3705 <name>Protein Wnt</name>
\r
3706 <gene_name>HrWnt-5beta</gene_name>
\r
3707 <mol_seq is_aligned="true">PCSEIPSLS---HSQRALCQKYRD--------HILLVSEGAQKGIEECQYQFRARRWNCSTTTNKKRKID-----------------------NNDSSTVFGK-VIDIG--SRETAFTYAISAAGVVHAIARGCKEGRL-EACGCSNSP--------------------RPDGLRDE---------------------------------------------------------------------WEWGGCGDNL-DYAYGFAHEFIDARERDNVSPRNLKSRSRKV--MNLHNNEAGRMTVVRGARPTCKCN---GVSGSCSLNT--------------------CWL-RVPHFREIGDKIREKHDS-SIEIKVNKRSRMRPR-----------------------------------------------------------------------------------------------KKSIE----SP----------TITDLVHLDSSPDYCRANSRT-GVLGTKGREC-------------NAH-SD---------GSDG-CGLMC--CGRGYDTRVVDVEE-RCNCR-FQ-----WCCVVRCQKCIKRVQRYICR</mol_seq>
\r
3708 <annotation ref="GO:0005578">
\r
3709 <desc>proteinaceous extracellular matrix</desc>
\r
3711 <annotation ref="GO:0007275">
\r
3712 <desc>multicellular organismal development</desc>
\r
3714 <annotation ref="GO:0016055">
\r
3715 <desc>Wnt signaling pathway</desc>
\r
3721 <name>WNT5_HALRO/52-363</name>
\r
3722 <branch_length>0.135</branch_length>
\r
3729 <id provider="uniprot">7729</id>
\r
3730 <code>HALRO</code>
\r
3731 <scientific_name>Halocynthia roretzi</scientific_name>
\r
3732 <common_name>Sea squirt</common_name>
\r
3733 <synonym>Cynthia roretzi</synonym>
\r
3734 <rank>species</rank>
\r
3736 <sequence type="protein">
\r
3737 <accession source="uniprot">O15978</accession>
\r
3738 <name>Protein Wnt-5</name>
\r
3739 <gene_name>WNT5</gene_name>
\r
3740 <mol_seq is_aligned="true">HCDEIRGLS---RNQRSLCRTYND--------HMYYVESGSKQGVEECQWQFRGQRWNCSLASN----------------------------------ASPDK-IIAVG--SKETAFTYAITSGGVVQSIARACKSGNL-MACGCSKRE--------------------RPTGLGKD---------------------------------------------------------------------WNWGGCGDDI-DYAYGFAHEFIDAQERDNSSPNDRRVKSHKA--MNIHNNEAGRLSVVRASHTTCKCH---GVSGSCSIKT--------------------CWL-QTPQFRTIGDKLRQRYDD-ALEMRVTHRGQMKTR-----------------------------------------------------------------------------------------------FSSDR----NP----------SNIDLVYIDSSPDYCKVNHKL-GILGTSGREC-------------QLD-SL---------AMDG-CGLMC--CGRGYTTKMVEVVK-SCNCK-FQ-----WCCFVKCQQCKEKVLKHICN</mol_seq>
\r
3741 <annotation ref="GO:0005578">
\r
3742 <desc>proteinaceous extracellular matrix</desc>
\r
3744 <annotation ref="GO:0007275">
\r
3745 <desc>multicellular organismal development</desc>
\r
3747 <annotation ref="GO:0016055">
\r
3748 <desc>Wnt signaling pathway</desc>
\r
3755 <name>A8WV10_CAEBR/44-360</name>
\r
3756 <branch_length>0.18334</branch_length>
\r
3763 <id provider="uniprot">6238</id>
\r
3764 <code>CAEBR</code>
\r
3765 <scientific_name>Caenorhabditis briggsae</scientific_name>
\r
3766 <rank>species</rank>
\r
3768 <sequence type="protein">
\r
3769 <accession source="uniprot">A8WV10</accession>
\r
3770 <name>Protein CBR-CWN-2</name>
\r
3771 <gene_name>cwn-2</gene_name>
\r
3772 <mol_seq is_aligned="true">PVCELPGLS---PGQAQVCELFKD--------HMPAVSIGAQNAIQECQRQFTGHRWNCSTHYST---------------------------------GMLGP-IHKMA--TREAAFTYAILSAGVTHEIGRRCKQGLL-TSCGCSDET--------------------KPKNVPTD---------------------------------------------------------------------WSWGGCGDNV-EYGYKFSRDFIDIREKEH-DPKRNHDNGRSL--MNRRNNEAGRKILKRHRKPKCKCH---GVSGACNMKT--------------------CWM-QLPSMEQVGKILRNKYDK-AIRVQINDRGNLQLLA----------------------------------------------------------------------------------------------DETSKERKTRA----------LPTDLVFMDDSPDYCRFDRHS-GTLGTEGRVC-------------KRG-SS---------GAEG-CDSLC--CGRGYNTYTQEVKS-KCNCK-FE-----WCCKVVCQTCNNMTQVDICK</mol_seq>
\r
3773 <annotation ref="GO:0005578">
\r
3774 <desc>proteinaceous extracellular matrix</desc>
\r
3776 <annotation ref="GO:0007275">
\r
3777 <desc>multicellular organismal development</desc>
\r
3779 <annotation ref="GO:0016055">
\r
3780 <desc>Wnt signaling pathway</desc>
\r
3782 <cross_references>
\r
3783 <accession source="CTD">8575733</accession>
\r
3784 </cross_references>
\r
3789 <name>Q5IHW1_NEMVE/31-358</name>
\r
3790 <branch_length>0.21141</branch_length>
\r
3793 <green>132</green>
\r
3797 <id provider="uniprot">45351</id>
\r
3798 <code>NEMVE</code>
\r
3799 <scientific_name>Nematostella vectensis</scientific_name>
\r
3800 <common_name>Starlet sea anemone</common_name>
\r
3801 <rank>species</rank>
\r
3803 <sequence type="protein">
\r
3804 <accession source="uniprot">Q5IHW1</accession>
\r
3805 <name>Protein Wnt</name>
\r
3806 <gene_name>Wnt5</gene_name>
\r
3807 <mol_seq is_aligned="true">LCMNLGGLT---REQIDLCQKNID--------HMASVGLGAKMAIQECQFQYQYEKWNCSIPDAEK-------------------------------SSLFER-ITSKDVATREAALTYAISSAGVVWALARACTEGNL-STCSCSRER--------------------RPLDLNKE---------------------------------------------------------------------YQWGGCGDNI-EYAVKFGREFMEAGEDHRPTEEDRKKYARTL--MNLHNNNLGRRVVKDISVVECKCH---GVCGSCNLKT--------------------CWR-QLVEFREIGNALHDKYDA-AVQVALKRKEGRSLLLPMR---------------------------------------------------------------------SR-------------------HYSQRKAKSAQE----------TRDELVYIDKSPDFCSKNAAH-GAQGTRGRKC-------------IKE-SL---------GKDG-CNLLC--CSRGYKMKKEVQAT-RCRCK-FH-----WCCKVKCKTCIKNVTTHICN</mol_seq>
\r
3808 <annotation ref="GO:0005578">
\r
3809 <desc>proteinaceous extracellular matrix</desc>
\r
3811 <annotation ref="GO:0007275">
\r
3812 <desc>multicellular organismal development</desc>
\r
3814 <annotation ref="GO:0016055">
\r
3815 <desc>Wnt signaling pathway</desc>
\r
3821 <name>A5AA55_HYDVU/16-337</name>
\r
3822 <branch_length>0.23324</branch_length>
\r
3825 <green>132</green>
\r
3829 <id provider="uniprot">6087</id>
\r
3830 <code>HYDVU</code>
\r
3831 <scientific_name>Hydra vulgaris</scientific_name>
\r
3832 <common_name>Hydra</common_name>
\r
3833 <synonym>Hydra attenuata</synonym>
\r
3834 <rank>species</rank>
\r
3836 <sequence type="protein">
\r
3837 <accession source="uniprot">A5AA55</accession>
\r
3838 <name>Protein Wnt</name>
\r
3839 <gene_name>wnt5</gene_name>
\r
3840 <mol_seq is_aligned="true">ICDKRRSLT---EKQIKLCNTNSD--------HMAYIIEGRRIAIEECMKQFSDRGWNCTFPEPN--------------------------------IIPFLHPYMPLG--TRETAFVHSIIAAATMHSISRACMENKLSSHCSCSQEK--------------------KPENLPKT---------------------------------------------------------------------DMWNGCGDNL-PYGYQFSKEFVDSKETIL--KDSAFNFGRVL--MNLHNNEAGRWAVFEKSKIQCRCH---GVSKNCATKT--------------------CYR-QLSEFKDVGYQLEQLHQS-AIHVQLSQSGQKNDTEIT-------------------------------------------------------------------------------------------KLVQFNSNIDIY----------TSKDMIYLDDSPSYCNQNLSI-GSFGTEGREC-------------IKD-DN---------SSKE-CGRLC--CEKGHYTKKVFTTE-NCACK-FI-----WCCEVKCQSCKKQQNKHYCK</mol_seq>
\r
3841 <annotation ref="GO:0005578">
\r
3842 <desc>proteinaceous extracellular matrix</desc>
\r
3844 <annotation ref="GO:0007275">
\r
3845 <desc>multicellular organismal development</desc>
\r
3847 <annotation ref="GO:0016055">
\r
3848 <desc>Wnt signaling pathway</desc>
\r
3854 <branch_length>0.00466</branch_length>
\r
3855 <confidence type="bootstrap">21</confidence>
\r
3857 <branch_length>0.03316</branch_length>
\r
3858 <confidence type="bootstrap">100</confidence>
\r
3860 <branch_length>0.01423</branch_length>
\r
3861 <confidence type="bootstrap">92</confidence>
\r
3863 <branch_length>0.00736</branch_length>
\r
3864 <confidence type="bootstrap">20</confidence>
\r
3866 <branch_length>0.00804</branch_length>
\r
3867 <confidence type="bootstrap">24</confidence>
\r
3869 <name>Q9TZT6_BRAFL/41-353</name>
\r
3870 <branch_length>0.09109</branch_length>
\r
3877 <id provider="uniprot">7739</id>
\r
3878 <code>BRAFL</code>
\r
3879 <scientific_name>Branchiostoma floridae</scientific_name>
\r
3880 <common_name>Florida lancelet</common_name>
\r
3881 <synonym>Amphioxus</synonym>
\r
3882 <rank>species</rank>
\r
3884 <sequence type="protein">
\r
3885 <accession source="uniprot">Q9TZT6</accession>
\r
3886 <name>Protein Wnt</name>
\r
3887 <gene_name>Wnt4</gene_name>
\r
3888 <mol_seq is_aligned="true">ACEKLHGLI---SRQVQICKRNVE--------VMDSVKEGARMSIEECQFQFRHRRWNCSTLINRR-------------------------------GPVFGK-VLEEG--TREAAFVHSISAAGVAHAVTRACSSGEL-ERCGCNRTV--------------------RGTIPEG----------------------------------------------------------------------FHWAGCSDNF-AFGAAFSQTFVDARERG----RVAATSSRAL--MNLHNNEAGRRNLVDHMKTECKCH---GVSGSCELKT--------------------CWR-AMPPFREVGARLKEKFDG-ATEVQQKKIGSRRELVPL--------------------------------------------------------------------------------------------NSDFK----PH----------SSSDLVYLDASPDFCVRDTKV-GSMGTVGRVC-------------NKT-SK---------AIDG-CELLC--CGRGYNTHTREVVE-RCSCK-FH-----WCCYVKCKTCRRTVEVHTCK</mol_seq>
\r
3889 <annotation ref="GO:0005578">
\r
3890 <desc>proteinaceous extracellular matrix</desc>
\r
3892 <annotation ref="GO:0007275">
\r
3893 <desc>multicellular organismal development</desc>
\r
3895 <annotation ref="GO:0016055">
\r
3896 <desc>Wnt signaling pathway</desc>
\r
3901 <name>Q8MPL6_PLADU/43-355</name>
\r
3902 <branch_length>0.09896</branch_length>
\r
3905 <green>132</green>
\r
3909 <id provider="uniprot">6359</id>
\r
3910 <code>PLADU</code>
\r
3911 <scientific_name>Platynereis dumerilii</scientific_name>
\r
3912 <common_name>Dumeril's clam worm</common_name>
\r
3913 <rank>species</rank>
\r
3915 <sequence type="protein">
\r
3916 <accession source="uniprot">Q8MPL6</accession>
\r
3917 <name>Protein Wnt</name>
\r
3918 <gene_name>wnt4</gene_name>
\r
3919 <mol_seq is_aligned="true">ECNVLDGLV---KKQKKICKKHVE--------MMGAVRKGAIEAIHECQFQFRNRRWNCSTVDAS---------------------------------TIFGN-VLHQG--SREASFVHAISSAGVAHPVTRACSSGTM-SECGCDRTV--------------------RGRSPAG----------------------------------------------------------------------FEWAGCSDNI-AFGTAFSRTFVDARERVR--KDREGSSSRVL--MNLHNNEAGRKIIEENMLTQCKCH---GVSGSCELKT--------------------CWR-AMPSFRKIGYMLKEKFDG-ACEVQQKKAGSRSVLVPR--------------------------------------------------------------------------------------------STQYK----PH----------SSTDLVYLVASPDFCERDPKT-GALGTHGRRC-------------NKT-SK---------AIDG-CELMC--CGRGYVTKKRVIIE-RCHCK-FH-----WCCYVKCQNCKREIEEHTCL</mol_seq>
\r
3920 <annotation ref="GO:0005578">
\r
3921 <desc>proteinaceous extracellular matrix</desc>
\r
3923 <annotation ref="GO:0007275">
\r
3924 <desc>multicellular organismal development</desc>
\r
3926 <annotation ref="GO:0016055">
\r
3927 <desc>Wnt signaling pathway</desc>
\r
3933 <branch_length>0.01701</branch_length>
\r
3934 <confidence type="bootstrap">54</confidence>
\r
3941 <id provider="uniprot">7955</id>
\r
3942 <scientific_name>Danio rerio</scientific_name>
\r
3943 <common_name>Zebrafish</common_name>
\r
3944 <synonym>Brachydanio rerio</synonym>
\r
3945 <rank>species</rank>
\r
3948 <name>Q1RLW9_DANRE/42-352</name>
\r
3949 <branch_length>0.0857</branch_length>
\r
3956 <id provider="uniprot">7955</id>
\r
3957 <code>DANRE</code>
\r
3958 <scientific_name>Danio rerio</scientific_name>
\r
3959 <common_name>Zebrafish</common_name>
\r
3960 <synonym>Brachydanio rerio</synonym>
\r
3961 <rank>species</rank>
\r
3963 <sequence type="protein">
\r
3964 <accession source="uniprot">Q1RLW9</accession>
\r
3965 <name>Protein Wnt</name>
\r
3966 <gene_name>wnt4a</gene_name>
\r
3967 <mol_seq is_aligned="true">TCEKLRGLI---QRQVQICKRNVE--------VMDAVRRGAQLAIDECQYQFRNRRWNCSTLESV---------------------------------PVFGK-VVTQG--TREAAFVYAISAASVAFAVTRACSSGEL-DKCGCDRNV--------------------HGVSPEG----------------------------------------------------------------------FQWSGCSDNI-AYGVAFSQSFVDIRER-----SKGQSSNRAL--MNLHNNEAGRKAILNHMRVECKCH---GVSGSCEVKT--------------------CWK-AMPPFRKVGNVIKEKFDG-ATEVELRKVGTTKVLVPR--------------------------------------------------------------------------------------------NSQFK----PH----------TDEDLVYLDPSPDFCEHDPRTPGIMGTAGRFC-------------NKT-SK---------AIDG-CELMC--CGRGFHTEEVEVVD-RCSCK-FH-----WCCYVKCKQCRKMVEMHTCR</mol_seq>
\r
3968 <annotation ref="GO:0005109">
\r
3969 <desc>frizzled binding</desc>
\r
3971 <annotation ref="GO:0005578">
\r
3972 <desc>proteinaceous extracellular matrix</desc>
\r
3974 <annotation ref="GO:0005615">
\r
3975 <desc>extracellular space</desc>
\r
3977 <annotation ref="GO:0007507">
\r
3978 <desc>heart development</desc>
\r
3980 <annotation ref="GO:0016055">
\r
3981 <desc>Wnt signaling pathway</desc>
\r
3983 <annotation ref="GO:0021986">
\r
3984 <desc>habenula development</desc>
\r
3986 <annotation ref="GO:0030182">
\r
3987 <desc>neuron differentiation</desc>
\r
3989 <annotation ref="GO:0042074">
\r
3990 <desc>cell migration involved in gastrulation</desc>
\r
3992 <annotation ref="GO:0045165">
\r
3993 <desc>cell fate commitment</desc>
\r
3995 <annotation ref="GO:0045893">
\r
3996 <desc>positive regulation of transcription, DNA-templated</desc>
\r
3998 <annotation ref="GO:0048841">
\r
3999 <desc>regulation of axon extension involved in axon guidance</desc>
\r
4001 <annotation ref="GO:0060070">
\r
4002 <desc>canonical Wnt signaling pathway</desc>
\r
4004 <annotation ref="GO:0070654">
\r
4005 <desc>sensory epithelium regeneration</desc>
\r
4007 <cross_references>
\r
4008 <accession source="CTD">30123</accession>
\r
4009 <accession source="KEGG">dre:30123</accession>
\r
4010 <accession source="NextBio">20806602</accession>
\r
4011 </cross_references>
\r
4015 <name>A3KQ12_DANRE/46-357</name>
\r
4016 <branch_length>0.10852</branch_length>
\r
4023 <id provider="uniprot">7955</id>
\r
4024 <code>DANRE</code>
\r
4025 <scientific_name>Danio rerio</scientific_name>
\r
4026 <common_name>Zebrafish</common_name>
\r
4027 <synonym>Brachydanio rerio</synonym>
\r
4028 <rank>species</rank>
\r
4030 <sequence type="protein">
\r
4031 <accession source="uniprot">A3KQ12</accession>
\r
4032 <name>Protein Wnt</name>
\r
4033 <gene_name>wnt4b</gene_name>
\r
4034 <mol_seq is_aligned="true">PCGRLRGLS---PGQVGVCRARGE--------VMESVRKASEMVIEECQHQFRNRRWNCSTTPRG--------------------------------INVFGR-VMNQG--TREAAFVHALSSAAVAVAVTRGCSRGEL-ERCGCDRKV--------------------RGVSPEG----------------------------------------------------------------------FQWSGCSDNL-SYGVAFSQTFVDEPER-----AKGMSSGRPL--MNIHNNEAGRKAILHNMQVECKCH---GVSGSCELRT--------------------CWK-VMPPFRRVGAVLKERFDG-ATEVRLTRVGSRTALLPR--------------------------------------------------------------------------------------------DPQVK----PP----------ATRDLVYLAPSPDFCRLDPDN-GIPGTAGRRC-------------NGT-SR--------LAPDG-CELLC--CGPGFRAGRAEVVQ-RCSCK-FS-----WCCSVRCQQCKNTVLIHTCR</mol_seq>
\r
4035 <annotation ref="GO:0005578">
\r
4036 <desc>proteinaceous extracellular matrix</desc>
\r
4038 <annotation ref="GO:0007275">
\r
4039 <desc>multicellular organismal development</desc>
\r
4041 <annotation ref="GO:0016055">
\r
4042 <desc>Wnt signaling pathway</desc>
\r
4049 <name>A2SVS6_9MOLL/48-358</name>
\r
4050 <branch_length>0.12714</branch_length>
\r
4053 <green>122</green>
\r
4057 <id provider="uniprot">6613</id>
\r
4058 <code>9MOLL</code>
\r
4059 <scientific_name>Euprymna scolopes</scientific_name>
\r
4060 <rank>phylum</rank>
\r
4062 <sequence type="protein">
\r
4063 <accession source="uniprot">A2SVS6</accession>
\r
4064 <name>Protein Wnt</name>
\r
4065 <mol_seq is_aligned="true">ECDNLTGLV---KRQKKICKKNLE--------MMNSVKQGAILAIQECQMQFRNRRWNCSSIDKL---------------------------------SLPGN-ILNRG--TREAAFVHAISAAAVAHSVTRACSSGKM-ERCGCDRTV-------------------HKNVTVQNS---------------------------------------------------------------------FLWSGCSDNV-AYGAAFSQRFVDARER------RRKINGRVL--MNLHNNQAGRNAIENHMKTMCKCH---GVSGACEMRT--------------------CWR-AILSFRKIGNLLREKFDG-ATEVRPKRKGSKRVLIPM--------------------------------------------------------------------------------------------NPKFK----HH----------TPNDLVYLLVSPDFCEPDNKT-GIPGTHGRLC-------------NLT-SK---------AIDG-CELMC--CGRGFNHRQRITSE-RCNCK-FN-----WCCVVECLMCPVVIEEFYCL</mol_seq>
\r
4066 <annotation ref="GO:0005578">
\r
4067 <desc>proteinaceous extracellular matrix</desc>
\r
4069 <annotation ref="GO:0007275">
\r
4070 <desc>multicellular organismal development</desc>
\r
4072 <annotation ref="GO:0016055">
\r
4073 <desc>Wnt signaling pathway</desc>
\r
4079 <name>Q5IRC3_NEMVE/41-354</name>
\r
4080 <branch_length>0.14035</branch_length>
\r
4083 <green>132</green>
\r
4087 <id provider="uniprot">45351</id>
\r
4088 <code>NEMVE</code>
\r
4089 <scientific_name>Nematostella vectensis</scientific_name>
\r
4090 <common_name>Starlet sea anemone</common_name>
\r
4091 <rank>species</rank>
\r
4093 <sequence type="protein">
\r
4094 <accession source="uniprot">Q5IRC3</accession>
\r
4095 <name>Protein Wnt</name>
\r
4096 <mol_seq is_aligned="true">NCDEIGQLS--NHRQVQVCKRNIQ--------VMDSVKDGASVALFECQHQFRYRPWNCTTVQFSR-------------------------------SPVFGN-SINGG--TREAAFVHAISSAGVAYAVTQACSSGRLGQKCGCDRKT--------------------RGQADG-----------------------------------------------------------------------FNWGGCSDDI-DFGMTFATRFVDARERG----SGIGSPARVL--MNLHNNRGGRLAVRKFMDLQCKCH---GVSGSCNIKT--------------------CWR-ALPNFRIVGDYIKEKFDG-ATEVEYKLIGGKHVLVPK--------------------------------------------------------------------------------------------NRKYK----PH----------TQMDLVYLVQSPDFCEPNPKT-GSLGTQGRIC-------------NRT-SQ---------AIDG-CDLMC--CGRGYVSRTEVRQE-QCACK-FF-----WCCHVRCQTCMRRVEVSYCK</mol_seq>
\r
4097 <annotation ref="GO:0005578">
\r
4098 <desc>proteinaceous extracellular matrix</desc>
\r
4100 <annotation ref="GO:0007275">
\r
4101 <desc>multicellular organismal development</desc>
\r
4103 <annotation ref="GO:0016055">
\r
4104 <desc>Wnt signaling pathway</desc>
\r
4110 <branch_length>0.01201</branch_length>
\r
4111 <confidence type="bootstrap">66</confidence>
\r
4113 <branch_length>0.05249</branch_length>
\r
4114 <confidence type="bootstrap">100</confidence>
\r
4121 <id provider="uniprot">7711</id>
\r
4122 <scientific_name>Chordata</scientific_name>
\r
4123 <rank>phylum</rank>
\r
4126 <branch_length>0.05276</branch_length>
\r
4127 <confidence type="bootstrap">100</confidence>
\r
4134 <id provider="uniprot">117571</id>
\r
4135 <scientific_name>Euteleostomi</scientific_name>
\r
4138 <branch_length>0.02534</branch_length>
\r
4139 <confidence type="bootstrap">99</confidence>
\r
4146 <name>WNT11_DANRE/43-354</name>
\r
4147 <branch_length>0.07896</branch_length>
\r
4154 <id provider="uniprot">7955</id>
\r
4155 <code>DANRE</code>
\r
4156 <scientific_name>Danio rerio</scientific_name>
\r
4157 <common_name>Zebrafish</common_name>
\r
4158 <synonym>Brachydanio rerio</synonym>
\r
4159 <rank>species</rank>
\r
4161 <sequence type="protein">
\r
4162 <accession source="uniprot">O73864</accession>
\r
4163 <name>Protein Wnt-11</name>
\r
4164 <gene_name>wnt11</gene_name>
\r
4165 <mol_seq is_aligned="true">HCKLLDGLV---PDQQQLCKRNLE--------LMHSIVRAARLTKSACTSSFSDMRWNWSSIESA---------------------------------PHFTP-DLAKG--TREAAFVVSLAAAVVSHAIARACASGDL-PSCSCAAMP--------------------SEQAAPD----------------------------------------------------------------------FRWGGCGDNLRYYGLQMGSAFSDAPMRN----RRSGPQDFRL--MQLHNNAVGRQVLMDSLEMKCKCH---GVSGSCSVKT--------------------CWK-GLQDISTISADLKSKYLS-ATKVIPRQIGTRRQLVPR--------------------------------------------------------------------------------------------EMEVR----PV----------GENELVYLVSSPDYCTQNAKQ-GSLGTTDRQC-------------NKT-AS---------GSES-CGLMC--CGRGYNAYTEVLVE-RCQCK-YH-----WCCYVSCKTCKRTVERYVSK</mol_seq>
\r
4166 <annotation ref="GO:0000132">
\r
4167 <desc>establishment of mitotic spindle orientation</desc>
\r
4169 <annotation ref="GO:0001702">
\r
4170 <desc>gastrulation with mouth forming second</desc>
\r
4172 <annotation ref="GO:0001839">
\r
4173 <desc>neural plate morphogenesis</desc>
\r
4175 <annotation ref="GO:0001947">
\r
4176 <desc>heart looping</desc>
\r
4178 <annotation ref="GO:0005099">
\r
4179 <desc>Ras GTPase activator activity</desc>
\r
4181 <annotation ref="GO:0005109">
\r
4182 <desc>frizzled binding</desc>
\r
4184 <annotation ref="GO:0005578">
\r
4185 <desc>proteinaceous extracellular matrix</desc>
\r
4187 <annotation ref="GO:0005615">
\r
4188 <desc>extracellular space</desc>
\r
4190 <annotation ref="GO:0005737">
\r
4191 <desc>cytoplasm</desc>
\r
4193 <annotation ref="GO:0005886">
\r
4194 <desc>plasma membrane</desc>
\r
4196 <annotation ref="GO:0006468">
\r
4197 <desc>protein phosphorylation</desc>
\r
4199 <annotation ref="GO:0007417">
\r
4200 <desc>central nervous system development</desc>
\r
4202 <annotation ref="GO:0007507">
\r
4203 <desc>heart development</desc>
\r
4205 <annotation ref="GO:0008078">
\r
4206 <desc>mesodermal cell migration</desc>
\r
4208 <annotation ref="GO:0008104">
\r
4209 <desc>protein localization</desc>
\r
4211 <annotation ref="GO:0010628">
\r
4212 <desc>positive regulation of gene expression</desc>
\r
4214 <annotation ref="GO:0016337">
\r
4215 <desc>single organismal cell-cell adhesion</desc>
\r
4217 <annotation ref="GO:0016477">
\r
4218 <desc>cell migration</desc>
\r
4220 <annotation ref="GO:0030100">
\r
4221 <desc>regulation of endocytosis</desc>
\r
4223 <annotation ref="GO:0030182">
\r
4224 <desc>neuron differentiation</desc>
\r
4226 <annotation ref="GO:0030295">
\r
4227 <desc>protein kinase activator activity</desc>
\r
4229 <annotation ref="GO:0030308">
\r
4230 <desc>negative regulation of cell growth</desc>
\r
4232 <annotation ref="GO:0030335">
\r
4233 <desc>positive regulation of cell migration</desc>
\r
4235 <annotation ref="GO:0030336">
\r
4236 <desc>negative regulation of cell migration</desc>
\r
4238 <annotation ref="GO:0032320">
\r
4239 <desc>positive regulation of Ras GTPase activity</desc>
\r
4241 <annotation ref="GO:0034394">
\r
4242 <desc>protein localization to cell surface</desc>
\r
4244 <annotation ref="GO:0035567">
\r
4245 <desc>non-canonical Wnt signaling pathway</desc>
\r
4247 <annotation ref="GO:0042074">
\r
4248 <desc>cell migration involved in gastrulation</desc>
\r
4250 <annotation ref="GO:0043010">
\r
4251 <desc>camera-type eye development</desc>
\r
4253 <annotation ref="GO:0043066">
\r
4254 <desc>negative regulation of apoptotic process</desc>
\r
4256 <annotation ref="GO:0044212">
\r
4257 <desc>transcription regulatory region DNA binding</desc>
\r
4259 <annotation ref="GO:0045859">
\r
4260 <desc>regulation of protein kinase activity</desc>
\r
4262 <annotation ref="GO:0045860">
\r
4263 <desc>positive regulation of protein kinase activity</desc>
\r
4265 <annotation ref="GO:0045892">
\r
4266 <desc>negative regulation of transcription, DNA-templated</desc>
\r
4268 <annotation ref="GO:0045893">
\r
4269 <desc>positive regulation of transcription, DNA-templated</desc>
\r
4271 <annotation ref="GO:0048048">
\r
4272 <desc>embryonic eye morphogenesis</desc>
\r
4274 <annotation ref="GO:0051496">
\r
4275 <desc>positive regulation of stress fiber assembly</desc>
\r
4277 <annotation ref="GO:0060021">
\r
4278 <desc>palate development</desc>
\r
4280 <annotation ref="GO:0060026">
\r
4281 <desc>convergent extension</desc>
\r
4283 <annotation ref="GO:0060027">
\r
4284 <desc>convergent extension involved in gastrulation</desc>
\r
4286 <annotation ref="GO:0060028">
\r
4287 <desc>convergent extension involved in axis elongation</desc>
\r
4289 <annotation ref="GO:0060031">
\r
4290 <desc>mediolateral intercalation</desc>
\r
4292 <annotation ref="GO:0060548">
\r
4293 <desc>negative regulation of cell death</desc>
\r
4295 <annotation ref="GO:0060898">
\r
4296 <desc>eye field cell fate commitment involved in camera-type eye formation</desc>
\r
4298 <annotation ref="GO:0061101">
\r
4299 <desc>neuroendocrine cell differentiation</desc>
\r
4301 <annotation ref="GO:0070121">
\r
4302 <desc>Kupffer's vesicle development</desc>
\r
4304 <annotation ref="GO:0090037">
\r
4305 <desc>positive regulation of protein kinase C signaling</desc>
\r
4307 <annotation ref="GO:0090090">
\r
4308 <desc>negative regulation of canonical Wnt signaling pathway</desc>
\r
4313 <name>WN11B_XENLA/42-353</name>
\r
4314 <branch_length>0.06668</branch_length>
\r
4321 <id provider="uniprot">8355</id>
\r
4322 <code>XENLA</code>
\r
4323 <scientific_name>Xenopus laevis</scientific_name>
\r
4324 <common_name>African clawed frog</common_name>
\r
4325 <rank>species</rank>
\r
4327 <sequence type="protein">
\r
4328 <symbol>XWnt-11</symbol>
\r
4329 <accession source="uniprot">P49893</accession>
\r
4330 <name>Protein Wnt-11b</name>
\r
4331 <gene_name>wnt11b</gene_name>
\r
4332 <mol_seq is_aligned="true">HCRLLDGLV---PDQSQLCKRNLE--------LMQSVVNAAKQTKLTCQMTLSDMRWNCSSVENA---------------------------------PSFTP-DLSKG--TRESAFVYALASATLSHTIARACASGEL-PTCSCGATP--------------------AEVPGTG----------------------------------------------------------------------FRWGGCGDNL-HYGLNMGSAFVDAPMKS---SKSAGTQATKI--MNLHNNAVGRQVLMDSLETKCKCH---GVSGSCSVKT--------------------CWK-GLQDLPHIANELKSKYLG-ATKVIHRQTGTRRQLVPR--------------------------------------------------------------------------------------------ELDIR----PV----------RESELVYLVSSPDYCTKNPKL-GSYGTQDRLC-------------NKT-SV---------GSDS-CNLMC--CGRGYNAYTETIVE-RCQCK-YH-----WCCYVMCKKCERTVERYVCK</mol_seq>
\r
4333 <annotation ref="GO:0001755">
\r
4334 <desc>neural crest cell migration</desc>
\r
4336 <annotation ref="GO:0005099">
\r
4337 <desc>Ras GTPase activator activity</desc>
\r
4339 <annotation ref="GO:0005109">
\r
4340 <desc>frizzled binding</desc>
\r
4342 <annotation ref="GO:0005515">
\r
4343 <desc>protein binding</desc>
\r
4345 <annotation ref="GO:0005576">
\r
4346 <desc>extracellular region</desc>
\r
4348 <annotation ref="GO:0005578">
\r
4349 <desc>proteinaceous extracellular matrix</desc>
\r
4351 <annotation ref="GO:0005615">
\r
4352 <desc>extracellular space</desc>
\r
4354 <annotation ref="GO:0005737">
\r
4355 <desc>cytoplasm</desc>
\r
4357 <annotation ref="GO:0005886">
\r
4358 <desc>plasma membrane</desc>
\r
4360 <annotation ref="GO:0006468">
\r
4361 <desc>protein phosphorylation</desc>
\r
4363 <annotation ref="GO:0006897">
\r
4364 <desc>endocytosis</desc>
\r
4366 <annotation ref="GO:0007507">
\r
4367 <desc>heart development</desc>
\r
4369 <annotation ref="GO:0009950">
\r
4370 <desc>dorsal/ventral axis specification</desc>
\r
4372 <annotation ref="GO:0010628">
\r
4373 <desc>positive regulation of gene expression</desc>
\r
4375 <annotation ref="GO:0016055">
\r
4376 <desc>Wnt signaling pathway</desc>
\r
4378 <annotation ref="GO:0017147">
\r
4379 <desc>Wnt-protein binding</desc>
\r
4381 <annotation ref="GO:0019838">
\r
4382 <desc>growth factor binding</desc>
\r
4384 <annotation ref="GO:0030295">
\r
4385 <desc>protein kinase activator activity</desc>
\r
4387 <annotation ref="GO:0030308">
\r
4388 <desc>negative regulation of cell growth</desc>
\r
4390 <annotation ref="GO:0030335">
\r
4391 <desc>positive regulation of cell migration</desc>
\r
4393 <annotation ref="GO:0030336">
\r
4394 <desc>negative regulation of cell migration</desc>
\r
4396 <annotation ref="GO:0032320">
\r
4397 <desc>positive regulation of Ras GTPase activity</desc>
\r
4399 <annotation ref="GO:0034394">
\r
4400 <desc>protein localization to cell surface</desc>
\r
4402 <annotation ref="GO:0035567">
\r
4403 <desc>non-canonical Wnt signaling pathway</desc>
\r
4405 <annotation ref="GO:0042074">
\r
4406 <desc>cell migration involved in gastrulation</desc>
\r
4408 <annotation ref="GO:0042803">
\r
4409 <desc>protein homodimerization activity</desc>
\r
4411 <annotation ref="GO:0043066">
\r
4412 <desc>negative regulation of apoptotic process</desc>
\r
4414 <annotation ref="GO:0043234">
\r
4415 <desc>protein complex</desc>
\r
4417 <annotation ref="GO:0044212">
\r
4418 <desc>transcription regulatory region DNA binding</desc>
\r
4420 <annotation ref="GO:0045860">
\r
4421 <desc>positive regulation of protein kinase activity</desc>
\r
4423 <annotation ref="GO:0045892">
\r
4424 <desc>negative regulation of transcription, DNA-templated</desc>
\r
4426 <annotation ref="GO:0045893">
\r
4427 <desc>positive regulation of transcription, DNA-templated</desc>
\r
4429 <annotation ref="GO:0046330">
\r
4430 <desc>positive regulation of JNK cascade</desc>
\r
4432 <annotation ref="GO:0048793">
\r
4433 <desc>pronephros development</desc>
\r
4435 <annotation ref="GO:0051496">
\r
4436 <desc>positive regulation of stress fiber assembly</desc>
\r
4438 <annotation ref="GO:0060021">
\r
4439 <desc>palate development</desc>
\r
4441 <annotation ref="GO:0060027">
\r
4442 <desc>convergent extension involved in gastrulation</desc>
\r
4444 <annotation ref="GO:0060070">
\r
4445 <desc>canonical Wnt signaling pathway</desc>
\r
4447 <annotation ref="GO:0060071">
\r
4448 <desc>Wnt signaling pathway, planar cell polarity pathway</desc>
\r
4450 <annotation ref="GO:0060548">
\r
4451 <desc>negative regulation of cell death</desc>
\r
4453 <annotation ref="GO:0060914">
\r
4454 <desc>heart formation</desc>
\r
4456 <annotation ref="GO:0061101">
\r
4457 <desc>neuroendocrine cell differentiation</desc>
\r
4459 <annotation ref="GO:0090037">
\r
4460 <desc>positive regulation of protein kinase C signaling</desc>
\r
4462 <annotation ref="GO:0090090">
\r
4463 <desc>negative regulation of canonical Wnt signaling pathway</desc>
\r
4465 <cross_references>
\r
4466 <accession source="CTD">399441</accession>
\r
4467 <accession source="KEGG">xla:399441</accession>
\r
4468 </cross_references>
\r
4473 <name>Q9I9I2_DANRE/42-352</name>
\r
4474 <branch_length>0.09097</branch_length>
\r
4481 <id provider="uniprot">7955</id>
\r
4482 <code>DANRE</code>
\r
4483 <scientific_name>Danio rerio</scientific_name>
\r
4484 <common_name>Zebrafish</common_name>
\r
4485 <synonym>Brachydanio rerio</synonym>
\r
4486 <rank>species</rank>
\r
4488 <sequence type="protein">
\r
4489 <accession source="uniprot">Q9I9I2</accession>
\r
4490 <name>Protein Wnt</name>
\r
4491 <gene_name>wnt11r</gene_name>
\r
4492 <mol_seq is_aligned="true">HCKTLPGLV---SSQAQLCRSNLE--------LMQTIIQAAREVKKVCQKTFTDMRWNCSSIDG----------------------------------PKFLP-DLERG--TRESAFVYALSAAAISHTIARACTSGDL-RLCSCGPIP--------------------GEIPEPG----------------------------------------------------------------------YRWGGCADNI-HYGLLMGSKFSDAPMKM---KKKSGSHANKL--MHLHNSEVGRQALRDALVMKCKCH---GVSGSCSIRT--------------------CWR-GLLDLKDIAIDLKTKYLS-ATKVVHRPMGTRKQLVPK--------------------------------------------------------------------------------------------DIDIR----PV----------RENELVYLQSSPDYCMKNDKL-GSFGTQDRQC-------------NKT-SS---------GSDS-CDLMC--CGRGYNPYTERVVE-RCHCK-YH-----WCCYVTCKKCDKTVEKYVCK</mol_seq>
\r
4493 <annotation ref="GO:0001947">
\r
4494 <desc>heart looping</desc>
\r
4496 <annotation ref="GO:0005109">
\r
4497 <desc>frizzled binding</desc>
\r
4499 <annotation ref="GO:0005578">
\r
4500 <desc>proteinaceous extracellular matrix</desc>
\r
4502 <annotation ref="GO:0005615">
\r
4503 <desc>extracellular space</desc>
\r
4505 <annotation ref="GO:0007507">
\r
4506 <desc>heart development</desc>
\r
4508 <annotation ref="GO:0016055">
\r
4509 <desc>Wnt signaling pathway</desc>
\r
4511 <annotation ref="GO:0030182">
\r
4512 <desc>neuron differentiation</desc>
\r
4514 <annotation ref="GO:0042074">
\r
4515 <desc>cell migration involved in gastrulation</desc>
\r
4517 <annotation ref="GO:0045165">
\r
4518 <desc>cell fate commitment</desc>
\r
4520 <cross_references>
\r
4521 <accession source="CTD">30283</accession>
\r
4522 <accession source="KEGG">dre:30283</accession>
\r
4523 <accession source="NextBio">20806727</accession>
\r
4524 </cross_references>
\r
4529 <name>Q9NCQ1_BRAFL/42-351</name>
\r
4530 <branch_length>0.13473</branch_length>
\r
4537 <id provider="uniprot">7739</id>
\r
4538 <code>BRAFL</code>
\r
4539 <scientific_name>Branchiostoma floridae</scientific_name>
\r
4540 <common_name>Florida lancelet</common_name>
\r
4541 <synonym>Amphioxus</synonym>
\r
4542 <rank>species</rank>
\r
4544 <sequence type="protein">
\r
4545 <accession source="uniprot">Q9NCQ1</accession>
\r
4546 <name>Protein Wnt</name>
\r
4547 <gene_name>Wnt11</gene_name>
\r
4548 <mol_seq is_aligned="true">SCRKVSGFV---PEQTQLCRRTLE--------VMPAVEYAAESARKTCQEQFGNRRWNCSSIKKA---------------------------------PHFMN-DLEKG--TKEAAYVHALSSAAVVHTVARACAAGYL-KACTCARNP--------------------GEKPDGN----------------------------------------------------------------------YTWGGCGDNV-KFGLEFGSRFADAPMR-----KKKRSHTQTL--MNLHNSEAGRLAVQNTMTTKCKCH---GVSGSCNVKT--------------------CWK-SLADLTEISHELAEKYSY-AIKVVKRKIGTRQQLVPE--------------------------------------------------------------------------------------------DRRSR----RH----------GSGDLIFVENSPNYCMVNNRK-GSYGTTGRLC-------------NKT-SV---------GPDS-CQTMC--CGRGYNDFTVTVTE-RCNCK-YH-----WCCYVTCDQCTRTEKKYMCK</mol_seq>
\r
4549 <annotation ref="GO:0005578">
\r
4550 <desc>proteinaceous extracellular matrix</desc>
\r
4552 <annotation ref="GO:0007275">
\r
4553 <desc>multicellular organismal development</desc>
\r
4555 <annotation ref="GO:0016055">
\r
4556 <desc>Wnt signaling pathway</desc>
\r
4562 <name>Q5IRC2_NEMVE/39-352</name>
\r
4563 <branch_length>0.2089</branch_length>
\r
4566 <green>132</green>
\r
4570 <id provider="uniprot">45351</id>
\r
4571 <code>NEMVE</code>
\r
4572 <scientific_name>Nematostella vectensis</scientific_name>
\r
4573 <common_name>Starlet sea anemone</common_name>
\r
4574 <rank>species</rank>
\r
4576 <sequence type="protein">
\r
4577 <accession source="uniprot">Q5IRC2</accession>
\r
4578 <name>Protein Wnt</name>
\r
4579 <mol_seq is_aligned="true">DCNRIHGFS---GKQYKICRRNLP--------AMLYVTAAVEMTREECQHQFQNKRWNCSTIV--K-------------------------------APQFLP-DLKRG--TPEAAFVYALSAAALTYSITQACGMKRL-KPCKCGTNP--------------------KFKHPD-----------------------------------------------------------------------GEWGGCHDNI-ARGMRFSKDFTDAVEAQR--MRKHKSMAVAL--MNLHNNGVGRKAVHSRLEFHCRCH---GVSGGCTAKT--------------------CIR-RLGDFRLVADLLKNRYAR-IVYVESKTKSKRKAR-----------------------------------------------------------------------------------------------VLKSKRGRRRY----------TSSDLVALQGSPNYCHKNRKR-GTAGTHGRLC-------------DPT-KR---------RGEGSCAYLC--CGRGHRTEEVVHEE-RCECK-YI-----WCCYVKCQTCRKRVRESRCL</mol_seq>
\r
4580 <annotation ref="GO:0005578">
\r
4581 <desc>proteinaceous extracellular matrix</desc>
\r
4583 <annotation ref="GO:0007275">
\r
4584 <desc>multicellular organismal development</desc>
\r
4586 <annotation ref="GO:0016055">
\r
4587 <desc>Wnt signaling pathway</desc>
\r
4596 <name>Q5TS73_ANOGA/68-376</name>
\r
4597 <branch_length>0.22168</branch_length>
\r
4600 <green>173</green>
\r
4604 <id provider="uniprot">7165</id>
\r
4605 <code>ANOGA</code>
\r
4606 <scientific_name>Anopheles gambiae</scientific_name>
\r
4607 <common_name>African malaria mosquito</common_name>
\r
4608 <rank>species</rank>
\r
4610 <sequence type="protein">
\r
4611 <accession source="uniprot">Q5TS73</accession>
\r
4612 <name>Protein Wnt</name>
\r
4613 <mol_seq is_aligned="true">LCGDTAFFT---EHQRDTCYSNPE--------LLKVIVHAANTAKYECQSYFQNNRWNCSAKRGS---------------------------------GIYYGNFDDKG--NRETAYLSAINSASLAWTITRFCTKGEL-TTCQCDRIP--------------------RNKHSTK----------------------------------------------------------------------WTWGGCSEDI-KYGIKQARSFTDPQE--------NRTTSFGL--MNLHNNEAARRILRSRMEKVCKCH---GMSGSCTTRV--------------------CWR-RLPPMKLIADTLGSLFDA-AAQVKPVENKGIIRKLMR-------------------------------------------------------------------------------------------KDLEYKK--V------------NKSDLVYIAESPNYCEENESL-GIFSTRGRFC-------------NRT-SY---------GIEG-CRLLC--CGRGYQTRIRNVEE-KCNCK-FV-----WCCSVKCDTCSMRKDEHICN</mol_seq>
\r
4614 <annotation ref="GO:0005578">
\r
4615 <desc>proteinaceous extracellular matrix</desc>
\r
4617 <annotation ref="GO:0007275">
\r
4618 <desc>multicellular organismal development</desc>
\r
4620 <annotation ref="GO:0016055">
\r
4621 <desc>Wnt signaling pathway</desc>
\r
4627 <branch_length>0.0143</branch_length>
\r
4628 <confidence type="bootstrap">71</confidence>
\r
4630 <branch_length>0.00663</branch_length>
\r
4631 <confidence type="bootstrap">49</confidence>
\r
4633 <name>A1DYI3_CHICK/44-355</name>
\r
4634 <branch_length>0.15137</branch_length>
\r
4641 <id provider="uniprot">9031</id>
\r
4642 <code>CHICK</code>
\r
4643 <scientific_name>Gallus gallus</scientific_name>
\r
4644 <common_name>Chicken</common_name>
\r
4645 <rank>species</rank>
\r
4647 <sequence type="protein">
\r
4648 <accession source="uniprot">A1DYI3</accession>
\r
4649 <name>Protein Wnt</name>
\r
4650 <gene_name>Wnt3</gene_name>
\r
4651 <mol_seq is_aligned="true">LCGSIPGLV---PKQLRFCRNYIE--------IMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDS--------------------------------LAIFGP-VLDKA--TRESAFVHAIASAGVAFAVTRSCAEGTS-TICGCDSHH--------------------KGPPGEG----------------------------------------------------------------------WKWGGCSEDA-DFGVLVSREFADARE--------NRPDARSA--MNRHNNEAGRTTILDHMHLKCKCH---GLSGSCEVKT--------------------CWW-AQPDFRAIGDYLKDKYDS-ASEMVVEKHRESRGWVETL---------------------------------------------------------------------RA-------------------KYALFK----PP----------TERDLVYYENSPNFCEPNPET-GSFGTRDRTC-------------NVT-SH---------GIDG-CDLLC--CGRGHNTRTEKRKE-KCHCI-FH-----WCCYVSCQECIRVYDVHTCK</mol_seq>
\r
4652 <annotation ref="GO:0001707">
\r
4653 <desc>mesoderm formation</desc>
\r
4655 <annotation ref="GO:0005578">
\r
4656 <desc>proteinaceous extracellular matrix</desc>
\r
4658 <annotation ref="GO:0007411">
\r
4659 <desc>axon guidance</desc>
\r
4661 <annotation ref="GO:0009948">
\r
4662 <desc>anterior/posterior axis specification</desc>
\r
4664 <annotation ref="GO:0009950">
\r
4665 <desc>dorsal/ventral axis specification</desc>
\r
4667 <annotation ref="GO:0010628">
\r
4668 <desc>positive regulation of gene expression</desc>
\r
4670 <annotation ref="GO:0035115">
\r
4671 <desc>embryonic forelimb morphogenesis</desc>
\r
4673 <annotation ref="GO:0035116">
\r
4674 <desc>embryonic hindlimb morphogenesis</desc>
\r
4676 <annotation ref="GO:0044338">
\r
4677 <desc>canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation</desc>
\r
4679 <annotation ref="GO:0044339">
\r
4680 <desc>canonical Wnt signaling pathway involved in osteoblast differentiation</desc>
\r
4682 <annotation ref="GO:0048697">
\r
4683 <desc>positive regulation of collateral sprouting in absence of injury</desc>
\r
4685 <annotation ref="GO:0048843">
\r
4686 <desc>negative regulation of axon extension involved in axon guidance</desc>
\r
4688 <annotation ref="GO:0060064">
\r
4689 <desc>Spemann organizer formation at the anterior end of the primitive streak</desc>
\r
4691 <annotation ref="GO:0060174">
\r
4692 <desc>limb bud formation</desc>
\r
4694 <annotation ref="GO:0060323">
\r
4695 <desc>head morphogenesis</desc>
\r
4697 <annotation ref="GO:0061180">
\r
4698 <desc>mammary gland epithelium development</desc>
\r
4700 <cross_references>
\r
4701 <accession source="CTD">7473</accession>
\r
4702 <accession source="KEGG">gga:374142</accession>
\r
4703 <accession source="NextBio">20813657</accession>
\r
4704 </cross_references>
\r
4708 <name>Q9GTJ9_HYDVU/47-363</name>
\r
4709 <branch_length>0.19186</branch_length>
\r
4712 <green>132</green>
\r
4716 <id provider="uniprot">6087</id>
\r
4717 <code>HYDVU</code>
\r
4718 <scientific_name>Hydra vulgaris</scientific_name>
\r
4719 <common_name>Hydra</common_name>
\r
4720 <synonym>Hydra attenuata</synonym>
\r
4721 <rank>species</rank>
\r
4723 <sequence type="protein">
\r
4724 <accession source="uniprot">Q9GTJ9</accession>
\r
4725 <name>Protein Wnt</name>
\r
4726 <gene_name>WNT3</gene_name>
\r
4727 <mol_seq is_aligned="true">LCRALYLHH----YQRTVCLNYTD--------LMLSVAEGIRLGIDECQVQFKHRKWNCTINEHG--------------------------------TSVFGP-IITTA--SRESAFISGIISAGVAFSVTESCAEGKS-VHCRCDNSV--------------------RGQTDEG----------------------------------------------------------------------WRWGGCNRPI-TYGIWFSQLFIDQVEKI----VKKRKDPRKI--MNLHNNKAGREVIKNLLQTECKCH---GTSGNCNLKT--------------------CWR-SQPHFSEIGKILKEKYDS-AHEMEFLYKVKANGERKIK----------------------------------------------------------------------D-------------------LIPKYKE-YLPP----------SSLDFIYYEESPNYCVKNETL-GIAGTKGRSC-------------NIT-SS---------GVDG-CELMC--CQRGYNVNIVQKTH-SCECK-FV-----WCCKVSCNSCIKMTPEYTCK</mol_seq>
\r
4728 <annotation ref="GO:0005578">
\r
4729 <desc>proteinaceous extracellular matrix</desc>
\r
4731 <annotation ref="GO:0007275">
\r
4732 <desc>multicellular organismal development</desc>
\r
4734 <annotation ref="GO:0016055">
\r
4735 <desc>Wnt signaling pathway</desc>
\r
4737 <cross_references>
\r
4738 <accession source="KEGG">hmg:100203050</accession>
\r
4739 </cross_references>
\r
4744 <name>A7RXF5_NEMVE/41-349</name>
\r
4745 <branch_length>0.16164</branch_length>
\r
4748 <green>132</green>
\r
4752 <id provider="uniprot">45351</id>
\r
4753 <code>NEMVE</code>
\r
4754 <scientific_name>Nematostella vectensis</scientific_name>
\r
4755 <common_name>Starlet sea anemone</common_name>
\r
4756 <rank>species</rank>
\r
4758 <sequence type="protein">
\r
4759 <accession source="uniprot">A7RXF5</accession>
\r
4760 <name>Protein Wnt</name>
\r
4761 <mol_seq is_aligned="true">LCYVTRQFN---SRQQEVCRKNPD--------LMEHVAHGAKYGVHECRHQFRNRRWNCSTIRES--------------------------------GSLFES-VLSKG--CREAAFVHAVTAAGVAHSVTDACSKGRI-ESCDCDRNL--------------------SGRSSKG----------------------------------------------------------------------WTWSGCNSNI-KFGVWFSKQFTEARE--------RGGDLRQI--MNRHNSRAGRKALEELVWRKCKCH---GLSGSCSMKT--------------------CWM-QQANFRQIGDHLKVKYDS-AVEMTTKVNRRGKKRLKP-------------------------------------------------------------------------------------------KYSHFK----KP----------SDKDLIYFETSPNYCDKNVTV-GSLGTSGRQC-------------NYT-SN---------GIDG-CELLC--CGRGHNIQQAKITR-NCNCV-FK-----WCCEVKCERCKEVVNIYTCK</mol_seq>
\r
4762 <annotation ref="GO:0005578">
\r
4763 <desc>proteinaceous extracellular matrix</desc>
\r
4765 <annotation ref="GO:0007275">
\r
4766 <desc>multicellular organismal development</desc>
\r
4768 <annotation ref="GO:0016055">
\r
4769 <desc>Wnt signaling pathway</desc>
\r
4776 <branch_length>0.014705</branch_length>
\r
4777 <confidence type="bootstrap">99</confidence>
\r
4779 <branch_length>0.02456</branch_length>
\r
4780 <confidence type="bootstrap">100</confidence>
\r
4782 <branch_length>0.01307</branch_length>
\r
4783 <confidence type="bootstrap">90</confidence>
\r
4785 <branch_length>0.00711</branch_length>
\r
4786 <confidence type="bootstrap">58</confidence>
\r
4788 <branch_length>0.00898</branch_length>
\r
4789 <confidence type="bootstrap">51</confidence>
\r
4791 <branch_length>0.08224</branch_length>
\r
4792 <confidence type="bootstrap">100</confidence>
\r
4795 <green>173</green>
\r
4799 <id provider="uniprot">33340</id>
\r
4800 <scientific_name>Neoptera</scientific_name>
\r
4801 <rank>subclass</rank>
\r
4804 <branch_length>0.03803</branch_length>
\r
4805 <confidence type="bootstrap">98</confidence>
\r
4808 <green>173</green>
\r
4812 <id provider="uniprot">33392</id>
\r
4813 <scientific_name>Endopterygota</scientific_name>
\r
4814 <rank>infraclass</rank>
\r
4817 <branch_length>0.14138</branch_length>
\r
4818 <confidence type="bootstrap">100</confidence>
\r
4821 <green>173</green>
\r
4825 <id provider="uniprot">7147</id>
\r
4826 <scientific_name>Diptera</scientific_name>
\r
4827 <rank>order</rank>
\r
4830 <name>Q16S09_AEDAE/31-428</name>
\r
4831 <branch_length>0.09724</branch_length>
\r
4834 <green>173</green>
\r
4838 <id provider="uniprot">7159</id>
\r
4839 <code>AEDAE</code>
\r
4840 <scientific_name>Aedes aegypti</scientific_name>
\r
4841 <common_name>Yellowfever mosquito</common_name>
\r
4842 <synonym>Culex aegypti</synonym>
\r
4843 <rank>species</rank>
\r
4845 <sequence type="protein">
\r
4846 <accession source="uniprot">Q16S09</accession>
\r
4847 <name>Protein Wnt</name>
\r
4848 <mol_seq is_aligned="true">MDPAIHATL--RRKQRRLARENPG--------VLAAIAKGANMAINECQHQFRNRRWNCSTRNFLR------------------------------GKNLFGK-IVERG--CRETAFIYAITSAAVTHSIARACSEGSI-ESCTCDYSHQSRAP---------QASTMGAVAGVRD----------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE--------RGRTLREK--MNLHNNEAGRAHVQSEMRQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRVVGDLLKDRFDG-ASRVMVSNSLRTSVNEA-TLSNRANPNGLKAQNQLGGSSPGGPNSV---------------SSNSIHARSHQQKKINRSFGDFQRWTKFLSKIFEFPSSINRYNFQLKPHNPDHK----PP----------GTKDLVYLEPSPGFCDRNPRL-GIQGTHGRQC-------------NDT-SI---------GVDG-CDLMC--CGRGYRTQEVIVVE-RCACT-FH-----WCCEVKCKLCRTKKIIHTCL</mol_seq>
\r
4849 <annotation ref="GO:0005578">
\r
4850 <desc>proteinaceous extracellular matrix</desc>
\r
4852 <annotation ref="GO:0007275">
\r
4853 <desc>multicellular organismal development</desc>
\r
4855 <annotation ref="GO:0016055">
\r
4856 <desc>Wnt signaling pathway</desc>
\r
4861 <name>WNTG_DROME/56-468</name>
\r
4862 <branch_length>0.23847</branch_length>
\r
4865 <green>173</green>
\r
4869 <id provider="uniprot">7227</id>
\r
4870 <code>DROME</code>
\r
4871 <scientific_name>Drosophila melanogaster</scientific_name>
\r
4872 <common_name>Fruit fly</common_name>
\r
4873 <rank>species</rank>
\r
4875 <sequence type="protein">
\r
4876 <accession source="uniprot">P09615</accession>
\r
4877 <name>Protein wingless</name>
\r
4878 <gene_name>wg</gene_name>
\r
4879 <mol_seq is_aligned="true">MDPAIHSTL--RRKQRRLVRDNPG--------VLGALVKGANLAISECQHQFRNRRWNCSTRNFSRGKNLF--------------------GKIVDRG-------------CRETSFIYAITSAAVTHSIARACSEGTI-ESCTCDYSHQSRSP---------QANHQAGSVAGVRD---------------------------------------------------------------------WEWGGCSDNI-GFGFKFSREFVDTGE----------RGRNLREKMNLHNNEAGRAHVQAEMRQECKCH---GMSGSCTVKT--------------------CWM-RLANFRVIGDNLKARFDG-ATRVQVTNSLR-ATNAL-APVSPNAAGSNSVGSNGLIIPQSGLVYGEEEERMLNDHMPDILLENSHPISKIHHPNMPSPNSLPQAGQRGGRNGRRQGRKHNRYHFQLNPHNPEHK----PP----------GSKDLVYLEPSPSFCEKNLRQ-GILGTHGRQC-------------NET-SL---------GVDG-CGLMC--CGRGYRRDEVVVVE-RCACTFH------WCCEVKCKLCRTKKVIYTCL</mol_seq>
\r
4880 <annotation ref="GO:0001745">
\r
4881 <desc>compound eye morphogenesis</desc>
\r
4883 <annotation ref="GO:0002168">
\r
4884 <desc>instar larval development</desc>
\r
4886 <annotation ref="GO:0003136">
\r
4887 <desc>negative regulation of heart induction by canonical Wnt signaling pathway</desc>
\r
4889 <annotation ref="GO:0005109">
\r
4890 <desc>frizzled binding</desc>
\r
4892 <annotation ref="GO:0005110">
\r
4893 <desc>frizzled-2 binding</desc>
\r
4895 <annotation ref="GO:0005112">
\r
4896 <desc>Notch binding</desc>
\r
4898 <annotation ref="GO:0005515">
\r
4899 <desc>protein binding</desc>
\r
4901 <annotation ref="GO:0005539">
\r
4902 <desc>glycosaminoglycan binding</desc>
\r
4904 <annotation ref="GO:0005576">
\r
4905 <desc>extracellular region</desc>
\r
4907 <annotation ref="GO:0005578">
\r
4908 <desc>proteinaceous extracellular matrix</desc>
\r
4910 <annotation ref="GO:0005615">
\r
4911 <desc>extracellular space</desc>
\r
4913 <annotation ref="GO:0005771">
\r
4914 <desc>multivesicular body</desc>
\r
4916 <annotation ref="GO:0005783">
\r
4917 <desc>endoplasmic reticulum</desc>
\r
4919 <annotation ref="GO:0005886">
\r
4920 <desc>plasma membrane</desc>
\r
4922 <annotation ref="GO:0006355">
\r
4923 <desc>regulation of transcription, DNA-templated</desc>
\r
4925 <annotation ref="GO:0007223">
\r
4926 <desc>Wnt signaling pathway, calcium modulating pathway</desc>
\r
4928 <annotation ref="GO:0007346">
\r
4929 <desc>regulation of mitotic cell cycle</desc>
\r
4931 <annotation ref="GO:0007367">
\r
4932 <desc>segment polarity determination</desc>
\r
4934 <annotation ref="GO:0007391">
\r
4935 <desc>dorsal closure</desc>
\r
4937 <annotation ref="GO:0007394">
\r
4938 <desc>dorsal closure, elongation of leading edge cells</desc>
\r
4940 <annotation ref="GO:0007398">
\r
4941 <desc>ectoderm development</desc>
\r
4943 <annotation ref="GO:0007418">
\r
4944 <desc>ventral midline development</desc>
\r
4946 <annotation ref="GO:0007419">
\r
4947 <desc>ventral cord development</desc>
\r
4949 <annotation ref="GO:0007423">
\r
4950 <desc>sensory organ development</desc>
\r
4952 <annotation ref="GO:0007442">
\r
4953 <desc>hindgut morphogenesis</desc>
\r
4955 <annotation ref="GO:0007444">
\r
4956 <desc>imaginal disc development</desc>
\r
4958 <annotation ref="GO:0007446">
\r
4959 <desc>imaginal disc growth</desc>
\r
4961 <annotation ref="GO:0007447">
\r
4962 <desc>imaginal disc pattern formation</desc>
\r
4964 <annotation ref="GO:0007448">
\r
4965 <desc>anterior/posterior pattern specification, imaginal disc</desc>
\r
4967 <annotation ref="GO:0007450">
\r
4968 <desc>dorsal/ventral pattern formation, imaginal disc</desc>
\r
4970 <annotation ref="GO:0007476">
\r
4971 <desc>imaginal disc-derived wing morphogenesis</desc>
\r
4973 <annotation ref="GO:0007479">
\r
4974 <desc>leg disc proximal/distal pattern formation</desc>
\r
4976 <annotation ref="GO:0007498">
\r
4977 <desc>mesoderm development</desc>
\r
4979 <annotation ref="GO:0007507">
\r
4980 <desc>heart development</desc>
\r
4982 <annotation ref="GO:0007523">
\r
4983 <desc>larval visceral muscle development</desc>
\r
4985 <annotation ref="GO:0007616">
\r
4986 <desc>long-term memory</desc>
\r
4988 <annotation ref="GO:0008284">
\r
4989 <desc>positive regulation of cell proliferation</desc>
\r
4991 <annotation ref="GO:0008544">
\r
4992 <desc>epidermis development</desc>
\r
4994 <annotation ref="GO:0008595">
\r
4995 <desc>anterior/posterior axis specification, embryo</desc>
\r
4997 <annotation ref="GO:0009986">
\r
4998 <desc>cell surface</desc>
\r
5000 <annotation ref="GO:0009996">
\r
5001 <desc>negative regulation of cell fate specification</desc>
\r
5003 <annotation ref="GO:0010002">
\r
5004 <desc>cardioblast differentiation</desc>
\r
5006 <annotation ref="GO:0014019">
\r
5007 <desc>neuroblast development</desc>
\r
5009 <annotation ref="GO:0016015">
\r
5010 <desc>morphogen activity</desc>
\r
5012 <annotation ref="GO:0016023">
\r
5013 <desc>cytoplasmic membrane-bounded vesicle</desc>
\r
5015 <annotation ref="GO:0016318">
\r
5016 <desc>ommatidial rotation</desc>
\r
5018 <annotation ref="GO:0030032">
\r
5019 <desc>lamellipodium assembly</desc>
\r
5021 <annotation ref="GO:0030054">
\r
5022 <desc>cell junction</desc>
\r
5024 <annotation ref="GO:0030139">
\r
5025 <desc>endocytic vesicle</desc>
\r
5027 <annotation ref="GO:0030182">
\r
5028 <desc>neuron differentiation</desc>
\r
5030 <annotation ref="GO:0030707">
\r
5031 <desc>ovarian follicle cell development</desc>
\r
5033 <annotation ref="GO:0032876">
\r
5034 <desc>negative regulation of DNA endoreduplication</desc>
\r
5036 <annotation ref="GO:0035017">
\r
5037 <desc>cuticle pattern formation</desc>
\r
5039 <annotation ref="GO:0035147">
\r
5040 <desc>branch fusion, open tracheal system</desc>
\r
5042 <annotation ref="GO:0035153">
\r
5043 <desc>epithelial cell type specification, open tracheal system</desc>
\r
5045 <annotation ref="GO:0035167">
\r
5046 <desc>larval lymph gland hemopoiesis</desc>
\r
5048 <annotation ref="GO:0035170">
\r
5049 <desc>lymph gland crystal cell differentiation</desc>
\r
5051 <annotation ref="GO:0035215">
\r
5052 <desc>genital disc development</desc>
\r
5054 <annotation ref="GO:0035217">
\r
5055 <desc>labial disc development</desc>
\r
5057 <annotation ref="GO:0035220">
\r
5058 <desc>wing disc development</desc>
\r
5060 <annotation ref="GO:0035224">
\r
5061 <desc>genital disc anterior/posterior pattern formation</desc>
\r
5063 <annotation ref="GO:0035225">
\r
5064 <desc>determination of genital disc primordium</desc>
\r
5066 <annotation ref="GO:0035263">
\r
5067 <desc>genital disc sexually dimorphic development</desc>
\r
5069 <annotation ref="GO:0035277">
\r
5070 <desc>spiracle morphogenesis, open tracheal system</desc>
\r
5072 <annotation ref="GO:0035288">
\r
5073 <desc>anterior head segmentation</desc>
\r
5075 <annotation ref="GO:0035289">
\r
5076 <desc>posterior head segmentation</desc>
\r
5078 <annotation ref="GO:0035290">
\r
5079 <desc>trunk segmentation</desc>
\r
5081 <annotation ref="GO:0035311">
\r
5082 <desc>wing cell fate specification</desc>
\r
5084 <annotation ref="GO:0042127">
\r
5085 <desc>regulation of cell proliferation</desc>
\r
5087 <annotation ref="GO:0042691">
\r
5088 <desc>positive regulation of crystal cell differentiation</desc>
\r
5090 <annotation ref="GO:0043066">
\r
5091 <desc>negative regulation of apoptotic process</desc>
\r
5093 <annotation ref="GO:0044719">
\r
5094 <desc>regulation of imaginal disc-derived wing size</desc>
\r
5096 <annotation ref="GO:0045121">
\r
5097 <desc>membrane raft</desc>
\r
5099 <annotation ref="GO:0045202">
\r
5100 <desc>synapse</desc>
\r
5102 <annotation ref="GO:0045611">
\r
5103 <desc>negative regulation of hemocyte differentiation</desc>
\r
5105 <annotation ref="GO:0045892">
\r
5106 <desc>negative regulation of transcription, DNA-templated</desc>
\r
5108 <annotation ref="GO:0046672">
\r
5109 <desc>positive regulation of compound eye retinal cell programmed cell death</desc>
\r
5111 <annotation ref="GO:0046847">
\r
5112 <desc>filopodium assembly</desc>
\r
5114 <annotation ref="GO:0048076">
\r
5115 <desc>regulation of compound eye pigmentation</desc>
\r
5117 <annotation ref="GO:0048190">
\r
5118 <desc>wing disc dorsal/ventral pattern formation</desc>
\r
5120 <annotation ref="GO:0048332">
\r
5121 <desc>mesoderm morphogenesis</desc>
\r
5123 <annotation ref="GO:0048542">
\r
5124 <desc>lymph gland development</desc>
\r
5126 <annotation ref="GO:0048728">
\r
5127 <desc>proboscis development</desc>
\r
5129 <annotation ref="GO:0048749">
\r
5130 <desc>compound eye development</desc>
\r
5132 <annotation ref="GO:0048754">
\r
5133 <desc>branching morphogenesis of an epithelial tube</desc>
\r
5135 <annotation ref="GO:0050840">
\r
5136 <desc>extracellular matrix binding</desc>
\r
5138 <annotation ref="GO:0051017">
\r
5139 <desc>actin filament bundle assembly</desc>
\r
5141 <annotation ref="GO:0060061">
\r
5142 <desc>Spemann organizer formation</desc>
\r
5144 <annotation ref="GO:0060070">
\r
5145 <desc>canonical Wnt signaling pathway</desc>
\r
5147 <annotation ref="GO:0060914">
\r
5148 <desc>heart formation</desc>
\r
5150 <annotation ref="GO:0061320">
\r
5151 <desc>pericardial nephrocyte differentiation</desc>
\r
5153 <annotation ref="GO:0061328">
\r
5154 <desc>posterior Malpighian tubule development</desc>
\r
5156 <annotation ref="GO:0061331">
\r
5157 <desc>epithelial cell proliferation involved in Malpighian tubule morphogenesis</desc>
\r
5159 <annotation ref="GO:0061332">
\r
5160 <desc>Malpighian tubule bud morphogenesis</desc>
\r
5162 <annotation ref="GO:0061382">
\r
5163 <desc>Malpighian tubule tip cell differentiation</desc>
\r
5165 <annotation ref="GO:0072091">
\r
5166 <desc>regulation of stem cell proliferation</desc>
\r
5168 <cross_references>
\r
5169 <accession source="CTD">474168</accession>
\r
5170 <accession source="NextBio">786411</accession>
\r
5171 </cross_references>
\r
5176 <name>WNT1_BOMMO/57-392</name>
\r
5177 <branch_length>0.0606</branch_length>
\r
5180 <green>173</green>
\r
5184 <id provider="uniprot">7091</id>
\r
5185 <code>BOMMO</code>
\r
5186 <scientific_name>Bombyx mori</scientific_name>
\r
5187 <common_name>Silk moth</common_name>
\r
5188 <rank>species</rank>
\r
5190 <sequence type="protein">
\r
5191 <accession source="uniprot">P49340</accession>
\r
5192 <name>Protein Wnt-1</name>
\r
5193 <gene_name>WNT-1</gene_name>
\r
5194 <mol_seq is_aligned="true">VHATL------RRKQRRLARENPG--------VLAAVAK-AQYAFAECQHQFKYRRWNCSTRNFLR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHSLARACREASI-ESCTCDYSHRPRAA---------QNPVGGRANVRV-----------------------------------------------------------------------WKWGGCSDNI-GFGFRFSREFVDTGE--------RGKTLREK--MNLHNNEAGRRHVQTEMKQECKCH---GMSGSCTVKT--------------------CWM-RLPSFRSVGDSLKDRFDG-ASRVMLSKADVETPAQR-NEAAPHR---------------------------------------------------------VPRKDRYR-FQL-------------RPHNPDHK----SP----------GVKDLVYLESSPGFCEKNPRL-GIPGTHGRAC-------------NDT-SI---------GVDG-CDLMC--CGRGYKTNTMFVVE-RCNCT-FH-----WCCEVKCKLCRTEKVVHTCL</mol_seq>
\r
5195 <annotation ref="GO:0005578">
\r
5196 <desc>proteinaceous extracellular matrix</desc>
\r
5198 <annotation ref="GO:0007275">
\r
5199 <desc>multicellular organismal development</desc>
\r
5201 <annotation ref="GO:0016055">
\r
5202 <desc>Wnt signaling pathway</desc>
\r
5204 <cross_references>
\r
5205 <accession source="CTD">692745</accession>
\r
5206 <accession source="KEGG">bmor:692745</accession>
\r
5207 </cross_references>
\r
5212 <name>Q9GRA6_GRYBI/62-394</name>
\r
5213 <branch_length>0.07433</branch_length>
\r
5216 <green>173</green>
\r
5220 <id provider="uniprot">6999</id>
\r
5221 <code>GRYBI</code>
\r
5222 <scientific_name>Gryllus bimaculatus</scientific_name>
\r
5223 <common_name>Two-spotted cricket</common_name>
\r
5224 <rank>species</rank>
\r
5226 <sequence type="protein">
\r
5227 <accession source="uniprot">Q9GRA6</accession>
\r
5228 <name>Protein Wnt</name>
\r
5229 <gene_name>wg</gene_name>
\r
5230 <mol_seq is_aligned="true">VHATL------RRKQRRLVRDHPG--------VLLAVVKGANQAIGECQFQFRNRRWNCSTKNFFR------------------------------GKNLFGK-IVDRG--CRETAFIYAITSAGVTHAIARACAEGSI-QSCTCDYRHAGRVA---------GGRGGGGGGGKKPD---------------------------------------------------------------------WEWGGCSDNI-EYGFKFSRDFVDTGE--------RGRTLREK--MNLHNNEAGRLHVREEMRKECKCH---GMSGSCTVKT--------------------CWM-RLPHFRVVGDNLKDRFDG-ASRVLVGNAGSPRGPGA-GKGKG-------------------------------------------------------------NRYNFQ-LQ---------------PYDAQHK----PP----------GRKDLVYLDQSPNFCERNPRQ-GIQGTHGREC-------------NET-SL---------GLDG-CDLMC--CGRGHRSQEVMLVE-RCHCT-FH-----WCCEVKCKTCHVRKTIHTCQ</mol_seq>
\r
5231 <annotation ref="GO:0005578">
\r
5232 <desc>proteinaceous extracellular matrix</desc>
\r
5234 <annotation ref="GO:0007275">
\r
5235 <desc>multicellular organismal development</desc>
\r
5237 <annotation ref="GO:0016055">
\r
5238 <desc>Wnt signaling pathway</desc>
\r
5244 <branch_length>0.0145</branch_length>
\r
5245 <confidence type="bootstrap">81</confidence>
\r
5248 <green>132</green>
\r
5252 <id provider="uniprot">6340</id>
\r
5253 <scientific_name>Annelida</scientific_name>
\r
5254 <rank>phylum</rank>
\r
5257 <name>Q2QJF8_9ANNE/61-379</name>
\r
5258 <branch_length>0.14789</branch_length>
\r
5261 <green>132</green>
\r
5265 <id provider="uniprot">283909</id>
\r
5266 <code>9ANNE</code>
\r
5267 <scientific_name>Capitella teleta</scientific_name>
\r
5268 <rank>phylum</rank>
\r
5270 <sequence type="protein">
\r
5271 <accession source="uniprot">Q2QJF8</accession>
\r
5272 <name>Protein Wnt</name>
\r
5273 <gene_name>wg</gene_name>
\r
5274 <mol_seq is_aligned="true">INPSLQPLT---RKQRRLVTRNPG--------TSIAIAKAARMAVDECQRQFSTRRWNCPVYDASH------------------------------GSSIFGK-VVRKG--IRECAFIYAIMSAALAHSIARSCAEGSI-YTCTCGRHSRRLAN---------SVQPRD-----------------------------------------------------------------------------WEWGGCSDNA-EFGRKFSHDFIDVAE--------KGRDLKCL--MNLHNSEAGRTQVSSEMSKECKCH---GMSGSCTVKT--------------------CWM-KLPMFGRVGKVVKDRFDG-ASQVEQGNGAINRSKNR-FN--------------------------------------------------------------------LI-P-----------------INTNHK----PP----------EPKDLVYFERSPTFCTKDPSI-GHTGTHGRPC-------------NAS-SI---------GVEG-CDLLC--CGRGYRSELYTARE-RCNCI-FH-----WCCKVTCDTCTKTKVRHICL</mol_seq>
\r
5275 <annotation ref="GO:0005578">
\r
5276 <desc>proteinaceous extracellular matrix</desc>
\r
5278 <annotation ref="GO:0007275">
\r
5279 <desc>multicellular organismal development</desc>
\r
5281 <annotation ref="GO:0016055">
\r
5282 <desc>Wnt signaling pathway</desc>
\r
5287 <name>Q8MPL8_PLADU/57-388</name>
\r
5288 <branch_length>0.14646</branch_length>
\r
5291 <green>132</green>
\r
5295 <id provider="uniprot">6359</id>
\r
5296 <code>PLADU</code>
\r
5297 <scientific_name>Platynereis dumerilii</scientific_name>
\r
5298 <common_name>Dumeril's clam worm</common_name>
\r
5299 <rank>species</rank>
\r
5301 <sequence type="protein">
\r
5302 <accession source="uniprot">Q8MPL8</accession>
\r
5303 <name>Protein Wnt</name>
\r
5304 <gene_name>wnt1</gene_name>
\r
5305 <mol_seq is_aligned="true">INPSLQPLT---RKQRRVVTRNPG--------TIVAVAKGARVAIHECQFQFRNRRWNCPTTEDGR------------------------------GGSIFGDIFKAAG--TRETAFIYAVTAAGVTHSVARACSEGSI-FTCSCGRRR--------------------RIDVTSSLPTSAAS---------------------------------------------------------IPPAATWEWGGCSDNI-EFGQRFSREFVDLVE--------KGRDLRYM--MNLHNNQAGRIHVVSEQHQECKCH---GMSGSCTVKT--------------------CWM-RLAPFRQTGARLKDRFDG-APRVYQGNSGNSRNRNRLQKF-----------------------------------------------------------------NLLPV-------------------NPNHK----SP----------GPQDLVYFEESPTFCDENRTL-GLQGTTGRQC-------------NVS-SI---------GVDG-CDLMC--CGRGWVEETYLSKE-RCNCT-FH-----WCGQVTCHICNRTRVRHLCL</mol_seq>
\r
5306 <annotation ref="GO:0005578">
\r
5307 <desc>proteinaceous extracellular matrix</desc>
\r
5309 <annotation ref="GO:0007275">
\r
5310 <desc>multicellular organismal development</desc>
\r
5312 <annotation ref="GO:0016055">
\r
5313 <desc>Wnt signaling pathway</desc>
\r
5320 <name>Q8T396_CUPSA/63-374</name>
\r
5321 <branch_length>0.11699</branch_length>
\r
5324 <green>173</green>
\r
5328 <id provider="uniprot">6928</id>
\r
5329 <code>CUPSA</code>
\r
5330 <scientific_name>Cupiennius salei</scientific_name>
\r
5331 <common_name>Wandering spider</common_name>
\r
5332 <rank>species</rank>
\r
5334 <sequence type="protein">
\r
5335 <accession source="uniprot">Q8T396</accession>
\r
5336 <name>Protein Wnt</name>
\r
5337 <gene_name>wg</gene_name>
\r
5338 <mol_seq is_aligned="true">PAPHLPLRK----KQRRLVRDNPG--------AMQAIGRGVKVAISECKYQFKKRRWNCPTADHAR------------------------------GKNIFGK-IVQRG--CRETAFLYAITSAGVTHSLSRACREGLV-STCNCDYRR--------------------RGPSGLH----------------------------------------------------------------------WEWGGCSDNI-DFGAKFSRQFVDASE--------RGKDLRYI--MNLHNNEAGRAHVIGGMRRQCKCH---GMSGSCTVQT--------------------CWM-QLSPFRTIGDGLKDRFDG-ASRVLVTNRGNVRRRAL-L---------------------------------------------------------------------KP-------------------YHPEHK----PP----------SKKDLVYFENSPDFCYADPSL-GHSATLGRTC-------------NVS-SL---------GVDG-CDLMC--CGRGYKSENREEVS-RCNCT-FH-----WCCQVECKTCKTKRLVHECL</mol_seq>
\r
5339 <annotation ref="GO:0005578">
\r
5340 <desc>proteinaceous extracellular matrix</desc>
\r
5342 <annotation ref="GO:0007275">
\r
5343 <desc>multicellular organismal development</desc>
\r
5345 <annotation ref="GO:0016055">
\r
5346 <desc>Wnt signaling pathway</desc>
\r
5352 <branch_length>0.06569</branch_length>
\r
5353 <confidence type="bootstrap">100</confidence>
\r
5360 <id provider="uniprot">117571</id>
\r
5361 <scientific_name>Euteleostomi</scientific_name>
\r
5364 <branch_length>0.00506</branch_length>
\r
5365 <confidence type="bootstrap">55</confidence>
\r
5372 <name>Q3UR96_MOUSE/57-370</name>
\r
5373 <branch_length>0.06041</branch_length>
\r
5380 <id provider="uniprot">10090</id>
\r
5381 <code>MOUSE</code>
\r
5382 <scientific_name>Mus musculus</scientific_name>
\r
5383 <common_name>Mouse</common_name>
\r
5384 <rank>species</rank>
\r
5386 <sequence type="protein">
\r
5387 <accession source="uniprot">Q3UR96</accession>
\r
5388 <name>Protein Wnt</name>
\r
5389 <gene_name>Wnt1</gene_name>
\r
5390 <mol_seq is_aligned="true">LEPSLQLLS---RKQRRLIRQNPG--------ILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP---------------------------------HLFGK-IVNRG--CRETAFIFAITSAGVTHSVARSCSEGSI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-DFGRLFGREFVDSGE--------KGRDLRFL--MNLHNNEAGRTTVFSEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPTLRAVGDVLRDRFDG-ASRVLYGNRGSNRAS---RAE-----------------------------------------------------------------LLRL-E----------------PEDPAHK----PP----------SPHDLVYFEKSPNFCTYSGRL-GTAGTAGRAC-------------NSS-SP---------ALDG-CELLC--CGRGHRTRTQRVTE-RCNCT-FH-----WCCHVSCRNCTHTRVLHECL</mol_seq>
\r
5391 <annotation ref="GO:0001658">
\r
5392 <desc>branching involved in ureteric bud morphogenesis</desc>
\r
5394 <annotation ref="GO:0001934">
\r
5395 <desc>positive regulation of protein phosphorylation</desc>
\r
5397 <annotation ref="GO:0005102">
\r
5398 <desc>receptor binding</desc>
\r
5400 <annotation ref="GO:0005109">
\r
5401 <desc>frizzled binding</desc>
\r
5403 <annotation ref="GO:0005515">
\r
5404 <desc>protein binding</desc>
\r
5406 <annotation ref="GO:0005578">
\r
5407 <desc>proteinaceous extracellular matrix</desc>
\r
5409 <annotation ref="GO:0005615">
\r
5410 <desc>extracellular space</desc>
\r
5412 <annotation ref="GO:0005737">
\r
5413 <desc>cytoplasm</desc>
\r
5415 <annotation ref="GO:0007165">
\r
5416 <desc>signal transduction</desc>
\r
5418 <annotation ref="GO:0007267">
\r
5419 <desc>cell-cell signaling</desc>
\r
5421 <annotation ref="GO:0007520">
\r
5422 <desc>myoblast fusion</desc>
\r
5424 <annotation ref="GO:0008284">
\r
5425 <desc>positive regulation of cell proliferation</desc>
\r
5427 <annotation ref="GO:0009611">
\r
5428 <desc>response to wounding</desc>
\r
5430 <annotation ref="GO:0009887">
\r
5431 <desc>organ morphogenesis</desc>
\r
5433 <annotation ref="GO:0009986">
\r
5434 <desc>cell surface</desc>
\r
5436 <annotation ref="GO:0010592">
\r
5437 <desc>positive regulation of lamellipodium assembly</desc>
\r
5439 <annotation ref="GO:0010812">
\r
5440 <desc>negative regulation of cell-substrate adhesion</desc>
\r
5442 <annotation ref="GO:0014902">
\r
5443 <desc>myotube differentiation</desc>
\r
5445 <annotation ref="GO:0016055">
\r
5446 <desc>Wnt signaling pathway</desc>
\r
5448 <annotation ref="GO:0021527">
\r
5449 <desc>spinal cord association neuron differentiation</desc>
\r
5451 <annotation ref="GO:0021536">
\r
5452 <desc>diencephalon development</desc>
\r
5454 <annotation ref="GO:0021797">
\r
5455 <desc>forebrain anterior/posterior pattern specification</desc>
\r
5457 <annotation ref="GO:0022004">
\r
5458 <desc>midbrain-hindbrain boundary maturation during brain development</desc>
\r
5460 <annotation ref="GO:0022037">
\r
5461 <desc>metencephalon development</desc>
\r
5463 <annotation ref="GO:0022408">
\r
5464 <desc>negative regulation of cell-cell adhesion</desc>
\r
5466 <annotation ref="GO:0030509">
\r
5467 <desc>BMP signaling pathway</desc>
\r
5469 <annotation ref="GO:0030512">
\r
5470 <desc>negative regulation of transforming growth factor beta receptor signaling pathway</desc>
\r
5472 <annotation ref="GO:0030514">
\r
5473 <desc>negative regulation of BMP signaling pathway</desc>
\r
5475 <annotation ref="GO:0030579">
\r
5476 <desc>ubiquitin-dependent SMAD protein catabolic process</desc>
\r
5478 <annotation ref="GO:0030901">
\r
5479 <desc>midbrain development</desc>
\r
5481 <annotation ref="GO:0030917">
\r
5482 <desc>midbrain-hindbrain boundary development</desc>
\r
5484 <annotation ref="GO:0031100">
\r
5485 <desc>organ regeneration</desc>
\r
5487 <annotation ref="GO:0033077">
\r
5488 <desc>T cell differentiation in thymus</desc>
\r
5490 <annotation ref="GO:0042472">
\r
5491 <desc>inner ear morphogenesis</desc>
\r
5493 <annotation ref="GO:0042770">
\r
5494 <desc>signal transduction in response to DNA damage</desc>
\r
5496 <annotation ref="GO:0043568">
\r
5497 <desc>positive regulation of insulin-like growth factor receptor signaling pathway</desc>
\r
5499 <annotation ref="GO:0044212">
\r
5500 <desc>transcription regulatory region DNA binding</desc>
\r
5502 <annotation ref="GO:0044336">
\r
5503 <desc>canonical Wnt signaling pathway involved in negative regulation of apoptotic process</desc>
\r
5505 <annotation ref="GO:0045599">
\r
5506 <desc>negative regulation of fat cell differentiation</desc>
\r
5508 <annotation ref="GO:0045747">
\r
5509 <desc>positive regulation of Notch signaling pathway</desc>
\r
5511 <annotation ref="GO:0045893">
\r
5512 <desc>positive regulation of transcription, DNA-templated</desc>
\r
5514 <annotation ref="GO:0045944">
\r
5515 <desc>positive regulation of transcription from RNA polymerase II promoter</desc>
\r
5517 <annotation ref="GO:0048146">
\r
5518 <desc>positive regulation of fibroblast proliferation</desc>
\r
5520 <annotation ref="GO:0048663">
\r
5521 <desc>neuron fate commitment</desc>
\r
5523 <annotation ref="GO:0048664">
\r
5524 <desc>neuron fate determination</desc>
\r
5526 <annotation ref="GO:0060070">
\r
5527 <desc>canonical Wnt signaling pathway</desc>
\r
5529 <annotation ref="GO:0060348">
\r
5530 <desc>bone development</desc>
\r
5532 <annotation ref="GO:0061184">
\r
5533 <desc>positive regulation of dermatome development</desc>
\r
5535 <annotation ref="GO:0070365">
\r
5536 <desc>hepatocyte differentiation</desc>
\r
5538 <annotation ref="GO:0071375">
\r
5539 <desc>cellular response to peptide hormone stimulus</desc>
\r
5541 <annotation ref="GO:0071425">
\r
5542 <desc>hematopoietic stem cell proliferation</desc>
\r
5544 <annotation ref="GO:0090344">
\r
5545 <desc>negative regulation of cell aging</desc>
\r
5547 <annotation ref="GO:2000059">
\r
5548 <desc>negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process</desc>
\r
5550 <cross_references>
\r
5551 <accession source="CTD">7471</accession>
\r
5552 <accession source="KEGG">mmu:22408</accession>
\r
5553 <accession source="NextBio">302801</accession>
\r
5554 </cross_references>
\r
5558 <name>Q4TCL8_TETNG/22-336</name>
\r
5559 <branch_length>0.05449</branch_length>
\r
5566 <id provider="uniprot">99883</id>
\r
5567 <code>TETNG</code>
\r
5568 <scientific_name>Tetraodon nigroviridis</scientific_name>
\r
5569 <common_name>Spotted green pufferfish</common_name>
\r
5570 <synonym>Chelonodon nigroviridis</synonym>
\r
5571 <rank>species</rank>
\r
5573 <sequence type="protein">
\r
5574 <accession source="uniprot">Q4TCL8</accession>
\r
5575 <name>Protein Wnt</name>
\r
5576 <mol_seq is_aligned="true">LDPSLALLS---RRQRRLIRQNPG--------ILHAIAAGLHAAIKECKWQFRNRRWNCPTTHSP---------------------------------AVFGK-IVNRG--CRETAFVFAITSAGVTHAVARSCSEGAI-ESCTCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNV-EFGRMFTREFVDSSE--------RGRDLRYL--TNLHNNEAGRMTVSTEMRQECKCH---GMSGSCTVRT--------------------CWM-RLPSFRTVGDFLKDRFDG-ASRVVYANKGSNRASH--KAN-----------------------------------------------------------------PRHL-E----------------PENPAHK----SP----------SSMDLVYFEKSPNFCSYSGKT-GTLGTSGRMC-------------NST-SP---------GLDG-CELLC--CGRGFKTRTETVTE-RCHCT-FH-----WCCHVSCLNCTSTRTLHQCV</mol_seq>
\r
5577 <annotation ref="GO:0005578">
\r
5578 <desc>proteinaceous extracellular matrix</desc>
\r
5580 <annotation ref="GO:0016055">
\r
5581 <desc>Wnt signaling pathway</desc>
\r
5583 <annotation ref="GO:0021587">
\r
5584 <desc>cerebellum morphogenesis</desc>
\r
5586 <annotation ref="GO:0021592">
\r
5587 <desc>fourth ventricle development</desc>
\r
5589 <annotation ref="GO:0030917">
\r
5590 <desc>midbrain-hindbrain boundary development</desc>
\r
5592 <annotation ref="GO:0035284">
\r
5593 <desc>brain segmentation</desc>
\r
5599 <name>WNT1_XENLA/58-371</name>
\r
5600 <branch_length>0.0706</branch_length>
\r
5607 <id provider="uniprot">8355</id>
\r
5608 <code>XENLA</code>
\r
5609 <scientific_name>Xenopus laevis</scientific_name>
\r
5610 <common_name>African clawed frog</common_name>
\r
5611 <rank>species</rank>
\r
5613 <sequence type="protein">
\r
5614 <symbol>XWnt-1</symbol>
\r
5615 <accession source="uniprot">P10108</accession>
\r
5616 <name>Protein Wnt-1</name>
\r
5617 <gene_name>wnt1</gene_name>
\r
5618 <mol_seq is_aligned="true">LDPSLQLLS----RQKRLIRQNPG--------ILQSITRGLHSAIRECKWHFRNRRWNCPTGTGN---------------------------------QVFGK-IINRG--CRETAFVFAITSAGVTHSVARSCSEGSI-ESCSCDYRR--------------------RGPGGPD----------------------------------------------------------------------WHWGGCSDNI-EFGRFIGREFVDSSE--------RGRDLKYL--VNLHNNQAGRLTVLTEMRQECKCH---GMSGSCSLRT--------------------CWM-RLPPFRSVGDALKDRFDG-ASKVTYSNNGSNRWGS--RSD-----------------------------------------------------------------PPHL-E----------------PENPTHA----LP----------SSQDLVYFEKSPNFCSPSEKN-GTPGTTGRIC-------------NST-SL---------GLDG-CELLC--CGRGYRSLAEKVTE-RCHCT-FN-----WCCHVTCLNCTSSQIVHECL</mol_seq>
\r
5619 <annotation ref="GO:0005578">
\r
5620 <desc>proteinaceous extracellular matrix</desc>
\r
5622 <annotation ref="GO:0014036">
\r
5623 <desc>neural crest cell fate specification</desc>
\r
5625 <annotation ref="GO:0016055">
\r
5626 <desc>Wnt signaling pathway</desc>
\r
5628 <annotation ref="GO:0021797">
\r
5629 <desc>forebrain anterior/posterior pattern specification</desc>
\r
5631 <annotation ref="GO:0045892">
\r
5632 <desc>negative regulation of transcription, DNA-templated</desc>
\r
5634 <cross_references>
\r
5635 <accession source="CTD">7471</accession>
\r
5636 <accession source="KEGG">xla:373578</accession>
\r
5637 </cross_references>
\r
5643 <name>O61699_BRAFL/59-377</name>
\r
5644 <branch_length>0.15398</branch_length>
\r
5651 <id provider="uniprot">7739</id>
\r
5652 <code>BRAFL</code>
\r
5653 <scientific_name>Branchiostoma floridae</scientific_name>
\r
5654 <common_name>Florida lancelet</common_name>
\r
5655 <synonym>Amphioxus</synonym>
\r
5656 <rank>species</rank>
\r
5658 <sequence type="protein">
\r
5659 <accession source="uniprot">O61699</accession>
\r
5660 <name>Protein Wnt</name>
\r
5661 <gene_name>Wnt1</gene_name>
\r
5662 <mol_seq is_aligned="true">LDPKKHPLN---KKQRRLVRRNPG-------DAGEHRDRRPMLAIKECHHQFSKWRWNCPVNTSDH------------------------------VNSVFGN-ILLRG--CTQTAFIYAVMSAAVAHEVGRNCAEGTI-ETCSCDYRS--------------------KGPAGED----------------------------------------------------------------------WEWGGCSDNV-EFGKQFAKQFVDAGE-------KTKDSVRYL--VNMHNNEAGRVAVAENLRRECKCH---GMSGSCTLKT--------------------CWM-RLPNFRDVGDSLKEKFDG-ASKVAFPDIGNNRGSRAKVT-------------------------------------------------------------------GLV-P-----------------KNSRHK----FP----------TDNDLVYHERSPNFCRNNPRL-GFEGTRGREC-------------NVT-SR---------GLDG-CDLLC--CGRGYATRQEVTKE-RCNCT-FQ-----WCCQVKCEECVRTKTIHTCL</mol_seq>
\r
5663 <annotation ref="GO:0005578">
\r
5664 <desc>proteinaceous extracellular matrix</desc>
\r
5666 <annotation ref="GO:0007275">
\r
5667 <desc>multicellular organismal development</desc>
\r
5669 <annotation ref="GO:0016055">
\r
5670 <desc>Wnt signaling pathway</desc>
\r
5676 <name>Q5J2D4_NEMVE/46-364</name>
\r
5677 <branch_length>0.17152</branch_length>
\r
5680 <green>132</green>
\r
5684 <id provider="uniprot">45351</id>
\r
5685 <code>NEMVE</code>
\r
5686 <scientific_name>Nematostella vectensis</scientific_name>
\r
5687 <common_name>Starlet sea anemone</common_name>
\r
5688 <rank>species</rank>
\r
5690 <sequence type="protein">
\r
5691 <accession source="uniprot">Q5J2D4</accession>
\r
5692 <name>Protein Wnt</name>
\r
5693 <mol_seq is_aligned="true">PPNQIRALT---QKQIRISRRYPE--------LIQYIAGGARTAIHECQHQFRNRKWNCSAHSPE---------------------------------NVFGK-ILKRA--CRETAFTYAITAAGVSHAIARACGEGKL-SACSCDQRY--------------------RGVSKQG----------------------------------------------------------------------WQWGGCSDNI-HFADNFSKRFVDAQE--------KGRDFRAQ--INLHNNEAGRAAVRNNMMLECKCH---GLSEACTVKT--------------------CWK-RLPDFRLVGDDLKAKFDD-ASMVEYQQNNNNRNSNRNRN-------------------------------------------------------------------EDP-A-----------------LFIPSKPYLRRP----------TVYDLGYYEHSPNFCERNPSA-GSLGTQGREC-------------NTT-SM---------GTDG-CELMC--CGRGFTTSSQERVE-NCNCRVFL-----GGCEVKCQKCKHEGSLSNCL</mol_seq>
\r
5694 <annotation ref="GO:0005578">
\r
5695 <desc>proteinaceous extracellular matrix</desc>
\r
5697 <annotation ref="GO:0007275">
\r
5698 <desc>multicellular organismal development</desc>
\r
5700 <annotation ref="GO:0016055">
\r
5701 <desc>Wnt signaling pathway</desc>
\r