2 <head><title>Alignment Conservation Annotation</title></head>
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3 <body><p><strong>Alignment Conservation Annotation</strong></p>
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4 <p>This is an automatically calculated quantitative alignment
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5 annotation which measures the number of conserved physico-chemical
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6 properties conserved for each column of the alignment. Its calculation
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7 is based on the one used in
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8 the AMAS method of multiple sequence alignment analysis :<br>
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10 C.D. and Barton G.J. (1993), Protein Sequence Alignments: A Strategy
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11 for the Hierarchical Analysis of Residue Conservation.<em>CABIOS</em> Vol. <b>9</b>
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15 <p>Conservation is measured as a numerical index reflecting the conservation of
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16 <a href="../misc/aaproperties.html">physico-chemical
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17 properties</a> in the alignment: Identities score highest, and the next most
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18 conserved group contain substitutions to amino acids lying in the same physico-chemical
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21 <p><em>Colouring an alignment by conservation</em><br>
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22 Conservation scores can be used to colour an alignment. This is
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23 explained further in the help page for <a
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24 href="../colourSchemes/conservation.html">conservation colouring</a>.
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