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22 <head><title>Alignment Conservation Annotation</title></head>
23 <body><p><strong>Alignment Conservation Annotation</strong></p>
24 <p>This is an automatically calculated quantitative alignment
25 annotation which measures the number of conserved physico-chemical
26 properties conserved for each column of the alignment. Its calculation
27 is based on the one used in
28 the AMAS method of multiple sequence alignment analysis :<br>
30 C.D. and Barton G.J. (1993), Protein Sequence Alignments: A Strategy
31 for the Hierarchical Analysis of Residue Conservation.<em>CABIOS</em> Vol. <b>9</b>
34 <em><a href="http://www.compbio.dundee.ac.uk/papers/amas/amas3d.html">View an HTML version of the paper</a></em>
36 <p>Conservation is measured as a numerical index reflecting the conservation of
37 <a href="../misc/aaproperties.html">physico-chemical
38 properties</a> in the alignment: Identities score highest, and the next most
39 conserved group contain substitutions to amino acids lying in the same physico-chemical
41 <p>Conservation is visualised on the alignment or a sequence group
42 as a histogram giving the score for each column. Conserved columns are
43 indicated by '*' (score of 11 with default amino acid property
44 grouping), and columns with mutations where all properties are
45 conserved are marked with a '+' (score of 10, indicating all
46 properties are conserved).</p>
48 <p><em>Colouring an alignment by conservation</em><br>
49 Conservation scores can be used to colour an alignment. This is
50 explained further in the help page for <a
51 href="../colourSchemes/conservation.html">conservation colouring</a>.