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20 * Jalview - A Sequence Alignment Editor and Viewer (Version 2.5)
21 * Copyright (C) 2010 J Procter, AM Waterhouse, G Barton, M Clamp, S Searle
23 * This file is part of Jalview.
25 * Jalview is free software: you can redistribute it and/or
26 * modify it under the terms of the GNU General Public License
27 * as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version.
29 * Jalview is distributed in the hope that it will be useful, but
30 * WITHOUT ANY WARRANTY; without even the implied warranty
31 * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
32 * PURPOSE. See the GNU General Public License for more details.
34 * You should have received a copy of the GNU General Public License along with Jalview. If not, see <http://www.gnu.org/licenses/>.
36 <head><title>Alignment Conservation Annotation</title></head>
37 <body><p><strong>Alignment Conservation Annotation</strong></p>
38 <p>This is an automatically calculated quantitative alignment
39 annotation which measures the number of conserved physico-chemical
40 properties conserved for each column of the alignment. Its calculation
41 is based on the one used in
42 the AMAS method of multiple sequence alignment analysis :<br>
44 C.D. and Barton G.J. (1993), Protein Sequence Alignments: A Strategy
45 for the Hierarchical Analysis of Residue Conservation.<em>CABIOS</em> Vol. <b>9</b>
49 <p>Conservation is measured as a numerical index reflecting the conservation of
50 <a href="../misc/aaproperties.html">physico-chemical
51 properties</a> in the alignment: Identities score highest, and the next most
52 conserved group contain substitutions to amino acids lying in the same physico-chemical
55 <p><em>Colouring an alignment by conservation</em><br>
56 Conservation scores can be used to colour an alignment. This is
57 explained further in the help page for <a
58 href="../colourSchemes/conservation.html">conservation colouring</a>.