2 <head><title>ClustalW Alignment</title></head>
\r
4 <p><strong>ClustalW Alignments</strong></p>
\r
5 <p>ClustalW is a program for multiple sequence alignment. It works
\r
6 with both DNA and protein sequences, and can also perform profile
\r
7 profile alignments to align two or more multiple sequence
\r
10 Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) <br>
\r
11 CLUSTAL W: improving the sensitivity of progressive multiple
\r
12 sequence alignment through sequence weighting, position specific gap
\r
13 penalties and weight matrix choice.<br>
\r
14 <em>Nucleic Acids Research</em> <strong>22</strong> 4673-4680
\r
16 <p>There are two versions of this alignment function, which will operate
\r
17 on the selected region, if any, or the whole sequence set:</p>
\r
19 <li><strong>Web Service→Alignment→ClustalW Multiple Sequence Alignment</strong><br>
\r
20 Aligns using the clustalW program, ignoring any gaps in the submitted sequence
\r
22 <li><strong>Web Service→Alignment→ClustalW Mulitple Sequence Alignment
\r
23 Realign </strong><br>
\r
24 Submits the sequences with existing gaps to clustalW, which will preserve
\r
25 existing gaps and re-align those regions which are not optimal. </li>
\r