3 # A DNA substitution matrix.
4 # This is an ad-hoc matrix which, in addition to penalising mutations between the common
5 # nucleotides (ACGT), includes T/U equivalence in order to allow both DNA and/or RNA.
6 # In addition, it encodes weak equivalence between R and Y with AG and CTU, respectively,
7 # and N is allowed to match any other base weakly.
8 # This matrix also includes I (Inosine) and X (Xanthine), but encodes them to weakly match
9 # any of (ACGTU), and unfavourably match each other.
11 # The first line declares a ScoreMatrix with the name DNA (shown in menus)
12 # Scores are not case sensitive, unless column(s) are provided for lower case characters
14 # Values may be integer or floating point, delimited by tab, space, comma or combinations
17 A 10 -8 -8 -8 -8 1 1 1 -8 1 1
18 C -8 10 -8 -8 -8 1 1 -8 1 1 1
19 G -8 -8 10 -8 -8 1 1 1 -8 1 1
20 T -8 -8 -8 10 10 1 1 -8 1 1 1
21 U -8 -8 -8 10 10 1 1 -8 1 1 1
22 I 1 1 1 1 1 10 0 0 0 1 1
23 X 1 1 1 1 1 0 10 0 0 1 1
24 R 1 -8 1 -8 -8 0 0 10 -8 1 1
25 Y -8 1 -8 1 1 0 0 -8 10 1 1
26 N 1 1 1 1 1 1 1 1 1 10 1
27 - 1 1 1 1 1 1 1 1 1 1 1