2 * Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
3 * Copyright (C) $$Year-Rel$$ The Jalview Authors
5 * This file is part of Jalview.
7 * Jalview is free software: you can redistribute it and/or
8 * modify it under the terms of the GNU General Public License
9 * as published by the Free Software Foundation, either version 3
10 * of the License, or (at your option) any later version.
12 * Jalview is distributed in the hope that it will be useful, but
13 * WITHOUT ANY WARRANTY; without even the implied warranty
14 * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
15 * PURPOSE. See the GNU General Public License for more details.
17 * You should have received a copy of the GNU General Public License
18 * along with Jalview. If not, see <http://www.gnu.org/licenses/>.
19 * The Jalview Authors are detailed in the 'AUTHORS' file.
21 package jalview.datamodel;
23 import java.util.List;
24 import java.util.Vector;
26 import fr.orsay.lri.varna.models.rna.RNA;
29 * Methods for manipulating a sequence, its metadata and related annotation in
30 * an alignment or dataset.
35 public interface SequenceI extends ASequenceI
38 * Set the display name for the sequence
42 public void setName(String name);
45 * Get the display name
47 public String getName();
50 * Set start position of first non-gapped symbol in sequence
55 public void setStart(int start);
58 * get start position of first non-gapped residue in sequence
62 public int getStart();
65 * get the displayed id of the sequence
67 * @return true means the id will be returned in the form
68 * DisplayName/Start-End
70 public String getDisplayId(boolean jvsuffix);
73 * set end position for last residue in sequence
77 public void setEnd(int end);
80 * get end position for last residue in sequence getEnd()>getStart() unless
81 * sequence only consists of gap characters
88 * @return length of sequence including gaps
91 public int getLength();
94 * Replace the sequence with the given string
99 public void setSequence(String sequence);
102 * @return sequence as string
104 public String getSequenceAsString();
107 * get a range on the sequence as a string
110 * position relative to start of sequence including gaps (from 0)
112 * position relative to start of sequence including gaps (from 0)
114 * @return String containing all gap and symbols in specified range
116 public String getSequenceAsString(int start, int end);
119 * Get the sequence as a character array
121 * @return seqeunce and any gaps
123 public char[] getSequence();
126 * get stretch of sequence characters in an array
129 * absolute index into getSequence()
131 * exclusive index of last position in segment to be returned.
133 * @return char[max(0,end-start)];
135 public char[] getSequence(int start, int end);
138 * create a new sequence object with a subsequence of this one but sharing the
139 * same dataset sequence
142 * int index for start position (base 0, inclusive)
144 * int index for end position (base 0, exclusive)
147 * @note implementations may use getSequence to get the sequence data
149 public SequenceI getSubSequence(int start, int end);
152 * get the i'th character in this sequence's local reference frame (ie from
153 * 0-number of characters lying from start-end)
157 * @return character or ' '
159 public char getCharAt(int i);
167 public void setDescription(String desc);
172 * @return DOCUMENT ME!
174 public String getDescription();
177 * Return the alignment column for a sequence position
180 * lying from start to end
182 * @return aligned column for residue (0 if residue is upstream from
183 * alignment, -1 if residue is downstream from alignment) note.
184 * Sequence object returns sequence.getEnd() for positions upstream
185 * currently. TODO: change sequence for
186 * assert(findIndex(seq.getEnd()+1)==-1) and fix incremental bugs
189 public int findIndex(int pos);
192 * Returns the sequence position for an alignment position
195 * column index in alignment (from 0..<length)
197 * @return residue number for residue (left of and) nearest ith column
199 public int findPosition(int i);
202 * Returns an int array where indices correspond to each residue in the
203 * sequence and the element value gives its position in the alignment
205 * @return int[SequenceI.getEnd()-SequenceI.getStart()+1] or null if no
206 * residues in SequenceI object
208 public int[] gapMap();
211 * Returns an int array where indices correspond to each position in sequence
212 * char array and the element value gives the result of findPosition for that
213 * index in the sequence.
215 * @return int[SequenceI.getLength()]
217 public int[] findPositionMap();
220 * Answers true if the sequence is composed of amino acid characters. Note
221 * that implementations may use heuristic methods which are not guaranteed to
222 * give the biologically 'right' answer.
226 public boolean isProtein();
229 * Delete a range of aligned sequence columns, creating a new dataset sequence
230 * if necessary and adjusting start and end positions accordingly.
233 * first column in range to delete (inclusive)
235 * last column in range to delete (exclusive)
237 public void deleteChars(int i, int j);
243 * alignment column number
245 * character to insert
247 public void insertCharAt(int i, char c);
250 * insert given character at alignment column position
253 * alignment column number
257 * character to insert
259 public void insertCharAt(int position, int count, char ch);
262 * Gets array holding sequence features associated with this sequence. The
263 * array may be held by the sequence's dataset sequence if that is defined.
265 * @return hard reference to array
267 public SequenceFeature[] getSequenceFeatures();
270 * Replaces the array of sequence features associated with this sequence with
271 * a new array reference. If this sequence has a dataset sequence, then this
272 * method will update the dataset sequence's feature array
275 * New array of sequence features
277 public void setSequenceFeatures(SequenceFeature[] features);
285 public void setPDBId(Vector<PDBEntry> ids);
290 * @return DOCUMENT ME!
292 public Vector<PDBEntry> getAllPDBEntries();
295 * Adds the entry to the *normalised* list of PDBIds.
297 * If a PDBEntry is passed with the same entry.getID() string as one already
298 * in the list, or one is added that appears to be the same but has a chain ID
299 * appended, then the existing PDBEntry will be updated with the new
300 * attributes instead, unless the entries have distinct chain codes or
301 * associated structure files.
304 * @return true if the entry was added, false if updated
306 public boolean addPDBId(PDBEntry entry);
309 * update the list of PDBEntrys to include any DBRefEntrys citing structural
312 * @return true if PDBEntry list was modified
314 public boolean updatePDBIds();
316 public String getVamsasId();
318 public void setVamsasId(String id);
321 * set the array of Database references for the sequence.
324 * @deprecated - use is discouraged since side-effects may occur if DBRefEntry
325 * set are not normalised.
328 public void setDBRefs(DBRefEntry[] dbs);
330 public DBRefEntry[] getDBRefs();
333 * add the given entry to the list of DBRefs for this sequence, or replace a
334 * similar one if entry contains a map object and the existing one doesnt.
338 public void addDBRef(DBRefEntry entry);
340 public void addSequenceFeature(SequenceFeature sf);
342 public void deleteFeature(SequenceFeature sf);
344 public void setDatasetSequence(SequenceI seq);
346 public SequenceI getDatasetSequence();
349 * Returns a new array containing this sequence's annotations, or null.
351 public AlignmentAnnotation[] getAnnotation();
354 * Returns true if this sequence has the given annotation (by object
357 public boolean hasAnnotation(AlignmentAnnotation ann);
360 * Add the given annotation, if not already added, and set its sequence ref to
361 * be this sequence. Does nothing if this sequence's annotations already
362 * include this annotation (by identical object reference).
364 public void addAlignmentAnnotation(AlignmentAnnotation annotation);
366 public void removeAlignmentAnnotation(AlignmentAnnotation annotation);
369 * Derive a sequence (using this one's dataset or as the dataset)
371 * @return duplicate sequence with valid dataset sequence
373 public SequenceI deriveSequence();
376 * set the array of associated AlignmentAnnotation for this sequenceI
380 public void setAlignmentAnnotation(AlignmentAnnotation[] annotation);
383 * Get one or more alignment annotations with a particular label.
386 * string which each returned annotation must have as a label.
387 * @return null or array of annotations.
389 public AlignmentAnnotation[] getAnnotation(String label);
392 * Returns a (possibly empty) list of any annotations that match on given
393 * calcId (source) and label (type). Null values do not match.
398 public List<AlignmentAnnotation> getAlignmentAnnotations(String calcId,
402 * create a new dataset sequence (if necessary) for this sequence and sets
403 * this sequence to refer to it. This call will move any features or
404 * references on the sequence onto the dataset. It will also make a duplicate
405 * of existing annotation rows for the dataset sequence, rather than relocate
406 * them in order to preserve external references (since 2.8.2).
408 * @return dataset sequence for this sequence
410 public SequenceI createDatasetSequence();
413 * Transfer any database references or annotation from entry under a sequence
415 * <strong>Note: DOES NOT transfer sequence associated alignment annotation
420 * null or mapping from entry's numbering to local start/end
422 public void transferAnnotation(SequenceI entry, Mapping mp);
426 * The sequence index in the MSA
428 public void setIndex(int index);
431 * @return The index of the sequence in the alignment
433 public int getIndex();
436 * @return The RNA of the sequence in the alignment
445 public void setRNA(RNA rna);
449 * @return list of insertions (gap characters) in sequence
451 public List<int[]> getInsertions();
454 * Given a pdbId String, return the equivalent PDBEntry if available in the
460 public PDBEntry getPDBEntry(String pdbId);
463 * Get all primary database/accessions for this sequence's data. These
464 * DBRefEntry are expected to resolve to a valid record in the associated
465 * external database, either directly or via a provided 1:1 Mapping.
467 * @return just the primary references (if any) for this sequence, or an empty
470 public List<DBRefEntry> getPrimaryDBRefs();