2 * Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
3 * Copyright (C) $$Year-Rel$$ The Jalview Authors
5 * This file is part of Jalview.
7 * Jalview is free software: you can redistribute it and/or
8 * modify it under the terms of the GNU General Public License
9 * as published by the Free Software Foundation, either version 3
10 * of the License, or (at your option) any later version.
12 * Jalview is distributed in the hope that it will be useful, but
13 * WITHOUT ANY WARRANTY; without even the implied warranty
14 * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
15 * PURPOSE. See the GNU General Public License for more details.
17 * You should have received a copy of the GNU General Public License
18 * along with Jalview. If not, see <http://www.gnu.org/licenses/>.
19 * The Jalview Authors are detailed in the 'AUTHORS' file.
21 package jalview.ext.ensembl;
23 import jalview.io.DataSourceType;
24 import jalview.io.FileParse;
25 import jalview.util.StringUtils;
27 import java.io.BufferedReader;
28 import java.io.DataOutputStream;
29 import java.io.IOException;
30 import java.io.InputStream;
31 import java.io.InputStreamReader;
32 import java.net.HttpURLConnection;
33 import java.net.MalformedURLException;
34 import java.net.ProtocolException;
36 import java.util.HashMap;
37 import java.util.List;
40 import javax.ws.rs.HttpMethod;
42 import org.json.simple.JSONArray;
43 import org.json.simple.JSONObject;
44 import org.json.simple.parser.JSONParser;
47 * Base class for Ensembl REST service clients
51 abstract class EnsemblRestClient extends EnsemblSequenceFetcher
53 private static final int DEFAULT_READ_TIMEOUT = 5 * 60 * 1000; // 5 minutes
55 private static final int CONNECT_TIMEOUT_MS = 10 * 1000; // 10 seconds
57 private static final int MAX_RETRIES = 3;
59 private static final int HTTP_OK = 200;
61 private static final int HTTP_OVERLOAD = 429;
64 * update these constants when Jalview has been checked / updated for
65 * changes to Ensembl REST API (ref JAL-2105)
66 * @see https://github.com/Ensembl/ensembl-rest/wiki/Change-log
67 * @see http://rest.ensembl.org/info/rest?content-type=application/json
69 private static final String LATEST_ENSEMBLGENOMES_REST_VERSION = "6.0";
71 private static final String LATEST_ENSEMBL_REST_VERSION = "6.1";
73 private static final String REST_CHANGE_LOG = "https://github.com/Ensembl/ensembl-rest/wiki/Change-log";
75 private static Map<String, EnsemblInfo> domainData = new HashMap<>();
77 private final static long AVAILABILITY_RETEST_INTERVAL = 10000L; // 10 seconds
79 private final static long VERSION_RETEST_INTERVAL = 1000L * 3600; // 1 hr
81 protected static final String CONTENT_TYPE_JSON = "?content-type=application/json";
85 domainData.put(DEFAULT_ENSEMBL_BASEURL,
86 new EnsemblInfo(DEFAULT_ENSEMBL_BASEURL, LATEST_ENSEMBL_REST_VERSION));
87 domainData.put(DEFAULT_ENSEMBL_GENOMES_BASEURL,
89 DEFAULT_ENSEMBL_GENOMES_BASEURL, LATEST_ENSEMBLGENOMES_REST_VERSION));
92 protected volatile boolean inProgress = false;
95 * Default constructor to use rest.ensembl.org
97 public EnsemblRestClient()
102 * initialise domain info lazily
104 if (!domainData.containsKey(ensemblDomain))
106 domainData.put(ensemblDomain,
107 new EnsemblInfo(ensemblDomain, LATEST_ENSEMBL_REST_VERSION));
109 if (!domainData.containsKey(ensemblGenomesDomain))
111 domainData.put(ensemblGenomesDomain, new EnsemblInfo(
112 ensemblGenomesDomain, LATEST_ENSEMBLGENOMES_REST_VERSION));
117 * Constructor given the target domain to fetch data from
121 public EnsemblRestClient(String d)
127 public boolean queryInProgress()
133 public StringBuffer getRawRecords()
139 * Returns the URL for the client http request
143 * @throws MalformedURLException
145 protected abstract URL getUrl(List<String> ids)
146 throws MalformedURLException;
149 * Returns true if client uses GET method, false if it uses POST
153 protected abstract boolean useGetRequest();
156 * Return the desired value for the Content-Type request header
161 * @see https://github.com/Ensembl/ensembl-rest/wiki/HTTP-Headers
163 protected abstract String getRequestMimeType(boolean multipleIds);
166 * Return the desired value for the Accept request header
169 * @see https://github.com/Ensembl/ensembl-rest/wiki/HTTP-Headers
171 protected abstract String getResponseMimeType();
174 * Checks Ensembl's REST 'ping' endpoint, and returns true if response
175 * indicates available, else false
177 * @see http://rest.ensembl.org/documentation/info/ping
180 boolean checkEnsembl()
182 BufferedReader br = null;
183 String pingUrl = getDomain() + "/info/ping" + CONTENT_TYPE_JSON;
186 // note this format works for both ensembl and ensemblgenomes
187 // info/ping.json works for ensembl only (March 2016)
188 URL ping = new URL(pingUrl);
191 * expect {"ping":1} if ok
192 * if ping takes more than 2 seconds to respond, treat as if unavailable
194 br = getHttpResponse(ping, null, 2 * 1000);
197 // error reponse status
200 JSONParser jp = new JSONParser();
201 JSONObject val = (JSONObject) jp.parse(br);
202 String pingString = val.get("ping").toString();
203 return pingString != null;
204 } catch (Throwable t)
207 "Error connecting to " + pingUrl + ": " + t.getMessage());
215 } catch (IOException e)
225 * returns a reader to a Fasta response from the Ensembl sequence endpoint
229 * @throws IOException
231 protected FileParse getSequenceReader(List<String> ids) throws IOException
233 URL url = getUrl(ids);
235 BufferedReader reader = getHttpResponse(url, ids);
241 FileParse fp = new FileParse(reader, url.toString(),
247 * Gets a reader to the HTTP response, using the default read timeout of 5
253 * @throws IOException
255 protected BufferedReader getHttpResponse(URL url, List<String> ids)
258 return getHttpResponse(url, ids, DEFAULT_READ_TIMEOUT);
262 * Sends the HTTP request and gets the response as a reader
266 * written as Json POST body if more than one
270 * @throws IOException
271 * if response code was not 200, or other I/O error
273 protected BufferedReader getHttpResponse(URL url, List<String> ids,
274 int readTimeout) throws IOException
276 int retriesLeft = MAX_RETRIES;
277 HttpURLConnection connection = null;
278 int responseCode = 0;
280 while (retriesLeft > 0)
282 connection = tryConnection(url, ids, readTimeout);
283 responseCode = connection.getResponseCode();
284 if (responseCode == HTTP_OVERLOAD) // 429
287 checkRetryAfter(connection);
294 if (responseCode != HTTP_OK) // 200
297 * note: a GET request for an invalid id returns an error code e.g. 415
298 * but POST request returns 200 and an empty Fasta response
300 System.err.println("Response code " + responseCode + " for " + url);
304 InputStream response = connection.getInputStream();
306 // System.out.println(getClass().getName() + " took "
307 // + (System.currentTimeMillis() - now) + "ms to fetch");
309 BufferedReader reader = null;
310 reader = new BufferedReader(new InputStreamReader(response, "UTF-8"));
319 * @throws IOException
320 * @throws ProtocolException
322 protected HttpURLConnection tryConnection(URL url, List<String> ids,
323 int readTimeout) throws IOException, ProtocolException
325 // System.out.println(System.currentTimeMillis() + " " + url);
326 HttpURLConnection connection = (HttpURLConnection) url.openConnection();
329 * POST method allows multiple queries in one request; it is supported for
330 * sequence queries, but not for overlap
332 boolean multipleIds = ids != null && ids.size() > 1;
333 connection.setRequestMethod(
334 multipleIds ? HttpMethod.POST : HttpMethod.GET);
335 connection.setRequestProperty("Content-Type",
336 getRequestMimeType(multipleIds));
337 connection.setRequestProperty("Accept", getResponseMimeType());
339 connection.setUseCaches(false);
340 connection.setDoInput(true);
341 connection.setDoOutput(multipleIds);
343 connection.setConnectTimeout(CONNECT_TIMEOUT_MS);
344 connection.setReadTimeout(readTimeout);
348 writePostBody(connection, ids);
354 * Inspects response headers for a 'retry-after' directive, and waits for the
355 * directed period (if less than 10 seconds)
357 * @see https://github.com/Ensembl/ensembl-rest/wiki/Rate-Limits
360 void checkRetryAfter(HttpURLConnection connection)
362 String retryDelay = connection.getHeaderField("Retry-After");
367 if (retryDelay != null)
371 int retrySecs = Integer.valueOf(retryDelay);
372 if (retrySecs > 0 && retrySecs < 10)
375 .println("Ensembl REST service rate limit exceeded, waiting "
376 + retryDelay + " seconds before retrying");
377 Thread.sleep(1000 * retrySecs);
379 } catch (NumberFormatException | InterruptedException e)
381 System.err.println("Error handling Retry-After: " + e.getMessage());
387 * Rechecks if Ensembl is responding, unless the last check was successful and
388 * the retest interval has not yet elapsed. Returns true if Ensembl is up,
389 * else false. Also retrieves and saves the current version of Ensembl data
390 * and REST services at intervals.
394 protected boolean isEnsemblAvailable()
396 EnsemblInfo info = domainData.get(getDomain());
398 long now = System.currentTimeMillis();
401 * recheck if Ensembl is up if it was down, or the recheck period has elapsed
403 boolean retestAvailability = (now
404 - info.lastAvailableCheckTime) > AVAILABILITY_RETEST_INTERVAL;
405 if (!info.restAvailable || retestAvailability)
407 info.restAvailable = checkEnsembl();
408 info.lastAvailableCheckTime = now;
412 * refetch Ensembl versions if the recheck period has elapsed
414 boolean refetchVersion = (now
415 - info.lastVersionCheckTime) > VERSION_RETEST_INTERVAL;
418 checkEnsemblRestVersion();
419 checkEnsemblDataVersion();
420 info.lastVersionCheckTime = now;
423 return info.restAvailable;
427 * Constructs, writes and flushes the POST body of the request, containing the
428 * query ids in JSON format
432 * @throws IOException
434 protected void writePostBody(HttpURLConnection connection,
435 List<String> ids) throws IOException
438 StringBuilder postBody = new StringBuilder(64);
439 postBody.append("{\"ids\":[");
441 for (String id : ids)
445 postBody.append(",");
448 postBody.append("\"");
449 postBody.append(id.trim());
450 postBody.append("\"");
452 postBody.append("]}");
453 byte[] thepostbody = postBody.toString().getBytes();
454 connection.setRequestProperty("Content-Length",
455 Integer.toString(thepostbody.length));
456 DataOutputStream wr = new DataOutputStream(
457 connection.getOutputStream());
458 wr.write(thepostbody);
464 * Fetches and checks Ensembl's REST version number
468 private void checkEnsemblRestVersion()
470 EnsemblInfo info = domainData.get(getDomain());
472 JSONParser jp = new JSONParser();
476 url = new URL(getDomain() + "/info/rest" + CONTENT_TYPE_JSON);
477 BufferedReader br = getHttpResponse(url, null);
482 JSONObject val = (JSONObject) jp.parse(br);
483 String version = val.get("release").toString();
484 String majorVersion = version.substring(0, version.indexOf("."));
485 String expected = info.expectedRestVersion;
486 String expectedMajorVersion = expected.substring(0,
487 expected.indexOf("."));
488 info.restMajorVersionMismatch = false;
492 * if actual REST major version is ahead of what we expect,
493 * record this in case we want to warn the user
495 if (Float.valueOf(majorVersion) > Float
496 .valueOf(expectedMajorVersion))
498 info.restMajorVersionMismatch = true;
500 } catch (NumberFormatException e)
502 System.err.println("Error in REST version: " + e.toString());
506 * check if REST version is later than what Jalview has tested against,
507 * if so warn; we don't worry if it is earlier (this indicates Jalview has
508 * been tested in advance against the next pending REST version)
510 boolean laterVersion = StringUtils.compareVersions(version,
514 System.err.println(String.format(
515 "EnsemblRestClient expected %s REST version %s but found %s, see %s",
516 getDbSource(), expected, version, REST_CHANGE_LOG));
518 info.restVersion = version;
519 } catch (Throwable t)
522 "Error checking Ensembl REST version: " + t.getMessage());
526 public boolean isRestMajorVersionMismatch()
528 return domainData.get(getDomain()).restMajorVersionMismatch;
532 * Fetches and checks Ensembl's data version number
536 private void checkEnsemblDataVersion()
538 JSONParser jp = new JSONParser();
540 BufferedReader br = null;
544 url = new URL(getDomain() + "/info/data" + CONTENT_TYPE_JSON);
545 br = getHttpResponse(url, null);
548 JSONObject val = (JSONObject) jp.parse(br);
549 JSONArray versions = (JSONArray) val.get("releases");
550 domainData.get(getDomain()).dataVersion = versions.get(0)
553 } catch (Throwable t)
556 "Error checking Ensembl data version: " + t.getMessage());
564 } catch (IOException e)
572 public String getEnsemblDataVersion()
574 return domainData.get(getDomain()).dataVersion;
578 public String getDbVersion()
580 return getEnsemblDataVersion();