-<p>
-<p><strong>Opening URLs from Jalview</strong><br>
-Both the applet and the desktop application are able to open URLs as
-'popups' in your web browser. <br>
-Double-clicking on the ID of a sequence will open the first URL that can
-be generated from its sequence ID. This is often the SRS site, but you
-can easily configure your own <a href="#urllinks>sequence URL links</a>.</p>
-<p>Other links for a sequence either derived from any other
-configured URL links, or imported from the sequence's annotation, are
-accessed by right clicking to open the sequence pop-up menu, and
-selecting from the <em>Links</em> submenu.</p>
-<p><strong><a name="urllinks">Configuring URL Links</a></strong>
-<br>URL links are defined in the "Connections" tab of the <a
- href="../features/preferences.html">Jalview desktop preferences</a>, or
-specified as <a
- href="http://www.jalview.org/examples/appletParameters.html#parameters">applet
-parameters</a>. <br>
-By default the item "SRS" is added to this link menu. This
-link will show a web page in your default browser with the selected
-sequence id as part of the URL.<br>
-In the preferences dialog box, click <strong>new</strong> to add a new
-link, and <strong>edit</strong> to modify an existing link, or <strong>delete</strong>
-to remove it.<br>
-You can name the link, this will be displayed on a new menu item under
-the "Link" menu when you right click on a sequence id. <br>
-The URL string must contain a token that can be replaced with a sequence
-ID. The simplest token is "$SEQUENCE_ID$", which will be
-replaced by the chosen sequence id when you click on it.</p>
-<p>eg.<br>
-UniRef100 =
-http://www.ebi.uniprot.org/uniprot-srv/uniRefView.do?proteinAc=$SEQUENCE_ID$&library=uniref100<br>
-Swissprot = http://www.expasy.org/uniprot/$SEQUENCE_ID$ <br>
-<br>
-Links will also be made for any database cross references associated
-with the sequence where the database name exactly matches a URL link
-name. In this case, the $SEQUENCE_ID$ string will be replaced with the
-accession string for the database cross-reference, rather than the
-sequence ID for the sequence (<em>since Jalview 2.4</em>).</p>
-<p><strong>Regular Expression Substitution</strong><br>
-A url may contain a string of the form $SEQUENCE_ID=/<em>regular
-expression</em>/=$. In this case, the regular expression will be applied to
-the full sequence ID string and the resulting match will be inserted
-into the URL. Groups of parentheses can be used to specify which regions
-of the regular expression will be used to generate the URL:
-<ul>
- <li>Each top level parenthesis will yield a URL containing the
- text matched within that parenthesis.</li>
- <li>Regions matching sub-parentheses within a top-level
- parenthesis will be concatenated to form the text inserted into the URL
- for the top-level parenthesis.</li>
- <em>Please Note:
- <ul>
- <li>The regular expressions supported by Jalview are those
- provided by the <a href="www.javaregex.com">Stevesoft javaregex
- package</a>.</li>
- <li>Some characters must be escaped when specifying them as a
- match within a regular expression.</li>
- </ul>
- <br>
- Many Thanks to Bernd Brandt of the Free University of Amsterdam for
- testing this new regular-expression expansion feature! </em>
- <em>
-</ul>
-</p>
-<p
+ <p>
+ <strong>Opening URLs from Jalview</strong><br> Both the applet
+ and the desktop application are able to open URLs as 'popups' in
+ your web browser.</p>
+ <p> Double-clicking on the ID of a sequence
+ will open whichever URL is selected for 'popups' in the <strong>"Links"</strong> tab of the <a
+ href="../features/preferences.html#links">Jalview desktop
+ preferences</a>.
+ This is by default the EMBL-EBI site, but you can easily configure your own <a
+ href="#urllinks">sequence URL links</a>.
+ </p>
+ <p>
+ Other links for a sequence, either derived from any other configured
+ URL links, or imported from the sequence's annotation, are accessed
+ by right clicking to open the sequence pop-up menu, and selecting
+ from the <em>Links</em> submenu.
+ </p>
+ <p>
+ <strong><a name="urllinks">Configuring URL Links</a></strong> <br>URL
+ links are defined in the "Links" tab of the <a
+ href="../features/preferences.html#links">Jalview desktop
+ preferences</a>, or specified as <a
+ href="http://www.jalview.org/examples/appletParameters.html#parameters">applet
+ parameters</a>.</p>
+ <p>
+ <em>Default Link Settings</em><br /> The "EMBL-EBI Search"
+ link is the default link shown in the "Link" submenu, and
+ opened when double-clicking on a sequence ID. When clicked, this
+ link will show a web page in your default browser with the selected
+ sequence ID as part of the URL.
+ </p>
+ <p>
+ <em>Adding additional links</em><br /> You can configure your own
+ links via the Jalview <a href="../features/preferences.html#links"><strong>Preferences</strong></a>
+ dialog. Jalview also provides persistent URLs for many common
+ bioinformatics databases (since 2.10.2). These links are downloaded by Jalview from
+ the <em>identifiers.org</em> website, and the names and URLs are not
+ user editable.
+ </p>
+ <p>
+ <em>Creating your own URL link</em> <br/>URL links are specified as a
+ template containing special tokens that Jalview will replace with
+ the Sequence ID or Database Accession of the sequence when you
+ double click on its ID or open it's <strong>Link</strong> submenu.
+ Link URL templates must contain at least one token.
+ </p>
+ <em>eg.</em><pre> UniRef100 =
+ http://www.ebi.uniprot.org/uniprot-srv/uniRefView.do?proteinAc=$SEQUENCE_ID$&library=uniref100<br/>
+ Swissprot = http://www.expasy.org/uniprot/$SEQUENCE_ID$ <br> </pre>
+ <p>
+ Links will also be made for any database cross references associated
+ with the sequence for any link templates whose name begins with the database name.
+ In this case, the $DB_ACCESSION$ string will be replaced with
+ the accession string for the database cross-reference, rather than
+ the sequence ID for the sequence (<em>since Jalview 2.10.1</em>).
+ <br /> <em>For example: to create a link for viewing MACiE records
+ from PDB Entries, create a new custom link entry with the name
+ "PDB in MACiE", and link URL template:
+ <pre>https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/MACiE/index.pl?query_pdb=1&pdb=$DBACCESSION$</pre>
+ <br />The sequence ID popup menu for seuqences with a PDB entry
+ will now show 'PDB in MACiE|1xyz..' links in the <strong>links</strong>
+ submenu.
+ </em>
+ </p>
+ <p>
+ <strong><a name="warning">Warning dialog about updating
+ your configured URL links</a></strong><br /> In the desktop
+ prior to Jalview 2.10.1, the only way to configure custom links for
+ a particular database cross-reference for a sequence was to give it
+ a name that
+ <em>exactly</em> matched the database source, and a regular
+ expression for filtering out any spurious matches generated when the
+ custom linked was tested against the Sequence's ID string. Since the
+ introduction of the $DB_ACCESSION$ token, however, $SEQUENCE_ID$
+ will not be used for database cross-reference accession strings, and
+ if you have custom links configured, Jalview will raise a warning
+ message so let you know that you may need to update your links to
+ use $DB_ACCESSION$.
+ </p>
+ <p>
+ <strong>Regular Expression Substitution</strong><br> A url may
+ contain a string of the form $SEQUENCE_ID=/<em>regular
+ expression</em>/=$ or $DB_ACCESSION=/<em>regular expression</em>/=$. In
+ this case, the regular expression will be applied to the full
+ sequence ID or DB accession ID string and the resulting match will
+ be inserted into the URL. Groups of parentheses can be used to
+ specify which regions of the regular expression will be used to
+ generate the URL:
+
+ <ul>
+ <li>Each top level parenthesis will yield a URL containing the
+ text matched within that parenthesis.</li>
+ <li>Regions matching sub-parentheses within a top-level
+ parenthesis will be concatenated to form the text inserted into
+ the URL for the top-level parenthesis.</li>
+ </ul>
+ <em>Please Note:</em>
+ <ul>
+ <li>The regular expressions supported by Jalview are those
+ provided by the <a href="http://www.javaregex.com">Stevesoft
+ javaregex package</a>.
+ </li>
+ <li>Some characters must be escaped when specifying them as a
+ match within a regular expression.</li>
+ </ul> <br> Many Thanks to Bernd Brandt of the Free University of
+ Amsterdam for testing the regular-expression expansion feature!