+ public List<DBRefEntry> getPrimaryDBRefs();
+
+ /**
+ * Updates mapping of Hidden Markov Model nodes to aligned sequence positions
+ * (e.g. after an alignment edit). The nodes of the HMM (excluding the first
+ * node, with model average values), are associated in turn with non-gapped
+ * sequence positions.
+ */
+ public void updateHMMMapping();
+
+ boolean isHMMConsensusSequence();
+
+ void setIsHMMConsensusSequence(boolean isHMMConsensusSequence);
+
+ /**
+ * Answers true if the sequence has annotation for Hidden Markov Model
+ * information content, else false
+ */
+ boolean hasHMMAnnotation();
+
+ /**
+ * Returns a (possibly empty) list of sequence features that overlap the given
+ * alignment column range, optionally restricted to one or more specified
+ * feature types. If the range is all gaps, then features which enclose it are
+ * included (but not contact features).
+ *
+ * @param fromCol
+ * start column of range inclusive (1..)
+ * @param toCol
+ * end column of range inclusive (1..)
+ * @param types
+ * optional feature types to restrict results to
+ * @return
+ */
+ List<SequenceFeature> findFeatures(int fromCol, int toCol, String... types);
+
+ /**
+ * Method to call to indicate that the sequence (characters or alignment/gaps)
+ * has been modified. Provided to allow any cursors on residue/column
+ * positions to be invalidated.
+ */
+ void sequenceChanged();
+
+ /**
+ *
+ * @return BitSet corresponding to index [0,length) where Comparison.isGap()
+ * returns true.
+ */
+ BitSet getInsertionsAsBits();
+
+ void mapToReference(AlignmentAnnotation rf);