+
+ /**
+ * Test that confirms adding a map twice does nothing
+ */
+ @Test(groups = { "Functional" })
+ public void testAddMapList_sameMap()
+ {
+ MapList ml = new MapList(new int[] { 11, 15, 20, 25, 35, 30 },
+ new int[]
+ { 72, 22 }, 1, 3);
+ String before = ml.toString();
+ ml.addMapList(ml);
+ assertEquals(before, ml.toString());
+ ml.addMapList(new MapList(ml));
+ assertEquals(before, ml.toString());
+ }
+
+ @Test(groups = { "Functional" })
+ public void testAddMapList_contiguous()
+ {
+ MapList ml = new MapList(new int[] { 11, 15 }, new int[] { 72, 58 }, 1,
+ 3);
+
+ MapList ml2 = new MapList(new int[] { 15, 16 }, new int[] { 58, 53 }, 1,
+ 3);
+ ml.addMapList(ml2);
+ assertEquals("[ [11, 16] ] 1:3 to [ [72, 53] ]", ml.toString());
+ }
+
+ @Test(groups = "Functional")
+ public void testAddRange()
+ {
+ int[] range = { 1, 5 };
+ List<int[]> ranges = new ArrayList<>();
+
+ // add to empty list:
+ MapList.addRange(range, ranges);
+ assertEquals(1, ranges.size());
+ assertSame(range, ranges.get(0));
+
+ // extend contiguous (same position):
+ MapList.addRange(new int[] { 5, 10 }, ranges);
+ assertEquals(1, ranges.size());
+ assertEquals(1, ranges.get(0)[0]);
+ assertEquals(10, ranges.get(0)[1]);
+
+ // extend contiguous (next position):
+ MapList.addRange(new int[] { 11, 15 }, ranges);
+ assertEquals(1, ranges.size());
+ assertEquals(1, ranges.get(0)[0]);
+ assertEquals(15, ranges.get(0)[1]);
+
+ // change direction: range is not merged:
+ MapList.addRange(new int[] { 16, 10 }, ranges);
+ assertEquals(2, ranges.size());
+ assertEquals(16, ranges.get(1)[0]);
+ assertEquals(10, ranges.get(1)[1]);
+
+ // extend reverse contiguous (same position):
+ MapList.addRange(new int[] { 10, 8 }, ranges);
+ assertEquals(2, ranges.size());
+ assertEquals(16, ranges.get(1)[0]);
+ assertEquals(8, ranges.get(1)[1]);
+
+ // extend reverse contiguous (next position):
+ MapList.addRange(new int[] { 7, 6 }, ranges);
+ assertEquals(2, ranges.size());
+ assertEquals(16, ranges.get(1)[0]);
+ assertEquals(6, ranges.get(1)[1]);
+
+ // change direction: range is not merged:
+ MapList.addRange(new int[] { 6, 9 }, ranges);
+ assertEquals(3, ranges.size());
+ assertEquals(6, ranges.get(2)[0]);
+ assertEquals(9, ranges.get(2)[1]);
+
+ // not contiguous: not merged
+ MapList.addRange(new int[] { 11, 12 }, ranges);
+ assertEquals(4, ranges.size());
+ assertEquals(11, ranges.get(3)[0]);
+ assertEquals(12, ranges.get(3)[1]);
+ }
+
+ /**
+ * Check state after construction
+ */
+ @Test(groups = { "Functional" })
+ public void testConstructor_withLists()
+ {
+ /*
+ * reverse direction
+ */
+ int[][] codons = new int[][] { { 9, 6 } };
+ int[][] protein = new int[][] { { 100, 91 }, { 80, 79 } };
+ MapList ml = new MapList(Arrays.asList(codons), Arrays.asList(protein),
+ 3, 1);
+ assertEquals(6, ml.getFromLowest());
+ assertEquals(9, ml.getFromHighest());
+ assertEquals(79, ml.getToLowest());
+ assertEquals(100, ml.getToHighest());
+ }
+
+ /**
+ * Test that method that inspects for the (first) forward or reverse from
+ * range. Single position ranges are ignored.
+ */
+ @Test(groups = { "Functional" })
+ public void testIsFromForwardStrand()
+ {
+ // [3-9] declares forward strand
+ MapList ml = new MapList(new int[] { 2, 2, 3, 9, 12, 11 },
+ new int[]
+ { 20, 11 }, 1, 1);
+ assertTrue(ml.isFromForwardStrand());
+
+ // [11-5] declares reverse strand ([13-14] is ignored)
+ ml = new MapList(new int[] { 2, 2, 11, 5, 13, 14 },
+ new int[]
+ { 20, 11 }, 1, 1);
+ assertFalse(ml.isFromForwardStrand());
+
+ // all single position ranges - defaults to forward strand
+ ml = new MapList(new int[] { 2, 2, 4, 4, 6, 6 }, new int[] { 3, 1 }, 1,
+ 1);
+ assertTrue(ml.isFromForwardStrand());
+ }
+
+ /**
+ * Test the method that merges contiguous ranges
+ */
+ @Test(groups = { "Functional" })
+ public void testCoalesceRanges()
+ {
+ assertNull(MapList.coalesceRanges(null));
+ List<int[]> ranges = new ArrayList<>();
+ assertSame(ranges, MapList.coalesceRanges(ranges));
+ ranges.add(new int[] { 1, 3 });
+ assertSame(ranges, MapList.coalesceRanges(ranges));
+
+ // add non-contiguous range:
+ ranges.add(new int[] { 5, 6 });
+ assertSame(ranges, MapList.coalesceRanges(ranges));
+
+ // 'contiguous' range in opposite direction is not merged:
+ ranges.add(new int[] { 7, 6 });
+ assertSame(ranges, MapList.coalesceRanges(ranges));
+
+ // merging in forward direction:
+ ranges.clear();
+ ranges.add(new int[] { 1, 3 });
+ ranges.add(new int[] { 4, 5 }); // contiguous
+ ranges.add(new int[] { 5, 5 }); // overlap!
+ ranges.add(new int[] { 6, 7 }); // contiguous
+ List<int[]> merged = MapList.coalesceRanges(ranges);
+ assertEquals(2, merged.size());
+ assertArrayEquals(new int[] { 1, 5 }, merged.get(0));
+ assertArrayEquals(new int[] { 5, 7 }, merged.get(1));
+ // verify input list is unchanged
+ assertEquals(4, ranges.size());
+ assertArrayEquals(new int[] { 1, 3 }, ranges.get(0));
+ assertArrayEquals(new int[] { 4, 5 }, ranges.get(1));
+ assertArrayEquals(new int[] { 5, 5 }, ranges.get(2));
+ assertArrayEquals(new int[] { 6, 7 }, ranges.get(3));
+
+ // merging in reverse direction:
+ ranges.clear();
+ ranges.add(new int[] { 7, 5 });
+ ranges.add(new int[] { 5, 4 }); // overlap
+ ranges.add(new int[] { 4, 4 }); // overlap
+ ranges.add(new int[] { 3, 1 }); // contiguous
+ merged = MapList.coalesceRanges(ranges);
+ assertEquals(3, merged.size());
+ assertArrayEquals(new int[] { 7, 5 }, merged.get(0));
+ assertArrayEquals(new int[] { 5, 4 }, merged.get(1));
+ assertArrayEquals(new int[] { 4, 1 }, merged.get(2));
+
+ // merging with switches of direction:
+ ranges.clear();
+ ranges.add(new int[] { 1, 3 });
+ ranges.add(new int[] { 4, 5 }); // contiguous
+ ranges.add(new int[] { 5, 5 }); // overlap
+ ranges.add(new int[] { 6, 6 }); // contiguous
+ ranges.add(new int[] { 12, 10 });
+ ranges.add(new int[] { 9, 8 }); // contiguous
+ ranges.add(new int[] { 8, 8 }); // overlap
+ ranges.add(new int[] { 7, 7 }); // contiguous
+ merged = MapList.coalesceRanges(ranges);
+ assertEquals(4, merged.size());
+ assertArrayEquals(new int[] { 1, 5 }, merged.get(0));
+ assertArrayEquals(new int[] { 5, 6 }, merged.get(1));
+ assertArrayEquals(new int[] { 12, 8 }, merged.get(2));
+ assertArrayEquals(new int[] { 8, 7 }, merged.get(3));
+
+ // 'subsumed' ranges are preserved
+ ranges.clear();
+ ranges.add(new int[] { 10, 30 });
+ ranges.add(new int[] { 15, 25 });
+ merged = MapList.coalesceRanges(ranges);
+ assertEquals(2, merged.size());
+ assertArrayEquals(new int[] { 10, 30 }, merged.get(0));
+ assertArrayEquals(new int[] { 15, 25 }, merged.get(1));
+ }
+
+ /**
+ * Test the method that compounds ('traverses') two mappings
+ */
+ @Test(groups = "Functional")
+ public void testTraverse()
+ {
+ /*
+ * simple 1:1 plus 1:1 forwards
+ */
+ MapList ml1 = new MapList(new int[] { 3, 4, 8, 12 },
+ new int[]
+ { 5, 8, 11, 13 }, 1, 1);
+ assertEquals("{[3, 4], [8, 12]}", prettyPrint(ml1.getFromRanges()));
+ assertEquals("{[5, 8], [11, 13]}", prettyPrint(ml1.getToRanges()));
+
+ MapList ml2 = new MapList(new int[] { 1, 50 },
+ new int[]
+ { 40, 45, 70, 75, 90, 127 }, 1, 1);
+ assertEquals("{[1, 50]}", prettyPrint(ml2.getFromRanges()));
+ assertEquals("{[40, 45], [70, 75], [90, 127]}",
+ prettyPrint(ml2.getToRanges()));
+
+ MapList compound = ml1.traverse(ml2);
+
+ assertEquals(1, compound.getFromRatio());
+ assertEquals(1, compound.getToRatio());
+ List<int[]> fromRanges = compound.getFromRanges();
+ assertEquals(2, fromRanges.size());
+ assertArrayEquals(new int[] { 3, 4 }, fromRanges.get(0));
+ assertArrayEquals(new int[] { 8, 12 }, fromRanges.get(1));
+ List<int[]> toRanges = compound.getToRanges();
+ assertEquals(4, toRanges.size());
+ // 5-8 maps to 44-45,70-71
+ // 11-13 maps to 74-75,90
+ assertArrayEquals(new int[] { 44, 45 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 70, 71 }, toRanges.get(1));
+ assertArrayEquals(new int[] { 74, 75 }, toRanges.get(2));
+ assertArrayEquals(new int[] { 90, 90 }, toRanges.get(3));
+
+ /*
+ * 1:1 over 1:1 backwards ('reverse strand')
+ */
+ ml1 = new MapList(new int[] { 1, 50 }, new int[] { 70, 119 }, 1, 1);
+ ml2 = new MapList(new int[] { 1, 500 },
+ new int[]
+ { 1000, 901, 600, 201 }, 1, 1);
+ compound = ml1.traverse(ml2);
+
+ assertEquals(1, compound.getFromRatio());
+ assertEquals(1, compound.getToRatio());
+ fromRanges = compound.getFromRanges();
+ assertEquals(1, fromRanges.size());
+ assertArrayEquals(new int[] { 1, 50 }, fromRanges.get(0));
+ toRanges = compound.getToRanges();
+ assertEquals(2, toRanges.size());
+ assertArrayEquals(new int[] { 931, 901 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 600, 582 }, toRanges.get(1));
+
+ /*
+ * 1:1 plus 1:3 should result in 1:3
+ */
+ ml1 = new MapList(new int[] { 1, 30 }, new int[] { 11, 40 }, 1, 1);
+ ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 50, 91, 340 }, 1,
+ 3);
+ compound = ml1.traverse(ml2);
+
+ assertEquals(1, compound.getFromRatio());
+ assertEquals(3, compound.getToRatio());
+ fromRanges = compound.getFromRanges();
+ assertEquals(1, fromRanges.size());
+ assertArrayEquals(new int[] { 1, 30 }, fromRanges.get(0));
+ // 11-40 maps to 31-50,91-160
+ toRanges = compound.getToRanges();
+ assertEquals(2, toRanges.size());
+ assertArrayEquals(new int[] { 31, 50 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 91, 160 }, toRanges.get(1));
+
+ /*
+ * 3:1 plus 1:1 should result in 3:1
+ */
+ ml1 = new MapList(new int[] { 1, 30 }, new int[] { 11, 20 }, 3, 1);
+ ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 15, 91, 175 }, 1,
+ 1);
+ compound = ml1.traverse(ml2);
+
+ assertEquals(3, compound.getFromRatio());
+ assertEquals(1, compound.getToRatio());
+ fromRanges = compound.getFromRanges();
+ assertEquals(1, fromRanges.size());
+ assertArrayEquals(new int[] { 1, 30 }, fromRanges.get(0));
+ // 11-20 maps to 11-15, 91-95
+ toRanges = compound.getToRanges();
+ assertEquals(2, toRanges.size());
+ assertArrayEquals(new int[] { 11, 15 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 91, 95 }, toRanges.get(1));
+
+ /*
+ * 1:3 plus 3:1 should result in 1:1
+ */
+ ml1 = new MapList(new int[] { 21, 40 }, new int[] { 13, 72 }, 1, 3);
+ ml2 = new MapList(new int[] { 1, 300 }, new int[] { 51, 70, 121, 200 },
+ 3, 1);
+ compound = ml1.traverse(ml2);
+
+ assertEquals(1, compound.getFromRatio());
+ assertEquals(1, compound.getToRatio());
+ fromRanges = compound.getFromRanges();
+ assertEquals(1, fromRanges.size());
+ assertArrayEquals(new int[] { 21, 40 }, fromRanges.get(0));
+ // 13-72 maps 3:1 to 55-70, 121-124
+ toRanges = compound.getToRanges();
+ assertEquals(2, toRanges.size());
+ assertArrayEquals(new int[] { 55, 70 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 121, 124 }, toRanges.get(1));
+
+ /*
+ * 3:1 plus 1:3 should result in 1:1
+ */
+ ml1 = new MapList(new int[] { 31, 90 }, new int[] { 13, 32 }, 3, 1);
+ ml2 = new MapList(new int[] { 11, 40 }, new int[] { 41, 50, 71, 150 },
+ 1, 3);
+ compound = ml1.traverse(ml2);
+
+ assertEquals(1, compound.getFromRatio());
+ assertEquals(1, compound.getToRatio());
+ fromRanges = compound.getFromRanges();
+ assertEquals(1, fromRanges.size());
+ assertArrayEquals(new int[] { 31, 90 }, fromRanges.get(0));
+ // 13-32 maps to 47-50,71-126
+ toRanges = compound.getToRanges();
+ assertEquals(2, toRanges.size());
+ assertArrayEquals(new int[] { 47, 50 }, toRanges.get(0));
+ assertArrayEquals(new int[] { 71, 126 }, toRanges.get(1));
+
+ /*
+ * method returns null if not all regions are mapped through
+ */
+ ml1 = new MapList(new int[] { 1, 50 }, new int[] { 101, 150 }, 1, 1);
+ ml2 = new MapList(new int[] { 131, 180 }, new int[] { 201, 250 }, 1, 3);
+ compound = ml1.traverse(ml2);
+ assertNull(compound);
+ }
+
+ /**
+ * Test that method that inspects for the (first) forward or reverse 'to'
+ * range. Single position ranges are ignored.
+ */
+ @Test(groups = { "Functional" })
+ public void testIsToForwardsStrand()
+ {
+ // [3-9] declares forward strand
+ MapList ml = new MapList(new int[] { 20, 11 },
+ new int[]
+ { 2, 2, 3, 9, 12, 11 }, 1, 1);
+ assertTrue(ml.isToForwardStrand());
+
+ // [11-5] declares reverse strand ([13-14] is ignored)
+ ml = new MapList(new int[] { 20, 11 },
+ new int[]
+ { 2, 2, 11, 5, 13, 14 }, 1, 1);
+ assertFalse(ml.isToForwardStrand());
+
+ // all single position ranges - defaults to forward strand
+ ml = new MapList(new int[] { 3, 1 }, new int[] { 2, 2, 4, 4, 6, 6 }, 1,
+ 1);
+ assertTrue(ml.isToForwardStrand());
+ }
+
+ /**
+ * Test for mapping with overlapping ranges
+ */
+ @Test(groups = { "Functional" })
+ public void testLocateInFrom_withOverlap()
+ {
+ int[] codons = new int[] { 1, 12, 12, 17 };
+ int[] protein = new int[] { 1, 6 };
+ MapList ml = new MapList(codons, protein, 3, 1);
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInFrom(1, 1)));
+ assertEquals("[4, 6]", Arrays.toString(ml.locateInFrom(2, 2)));
+ assertEquals("[7, 9]", Arrays.toString(ml.locateInFrom(3, 3)));
+ assertEquals("[10, 12]", Arrays.toString(ml.locateInFrom(4, 4)));
+ assertEquals("[12, 14]", Arrays.toString(ml.locateInFrom(5, 5)));
+ assertEquals("[15, 17]", Arrays.toString(ml.locateInFrom(6, 6)));
+ assertEquals("[1, 6]", Arrays.toString(ml.locateInFrom(1, 2)));
+ assertEquals("[1, 9]", Arrays.toString(ml.locateInFrom(1, 3)));
+ assertEquals("[1, 12]", Arrays.toString(ml.locateInFrom(1, 4)));
+ assertEquals("[1, 12, 12, 14]", Arrays.toString(ml.locateInFrom(1, 5)));
+ assertEquals("[1, 12, 12, 17]", Arrays.toString(ml.locateInFrom(1, 6)));
+ assertEquals("[4, 9]", Arrays.toString(ml.locateInFrom(2, 3)));
+ assertEquals("[7, 12, 12, 17]", Arrays.toString(ml.locateInFrom(3, 6)));
+
+ assertNull(ml.locateInFrom(0, 0));
+ assertNull(ml.locateInFrom(1, 7));
+ assertNull(ml.locateInFrom(-1, 1));
+ }
+
+ /**
+ * Test for mapping with overlapping ranges
+ */
+ @Test(groups = { "Functional" })
+ public void testLocateInTo_withOverlap()
+ {
+ int[] codons = new int[] { 1, 12, 12, 17 };
+ int[] protein = new int[] { 1, 6 };
+ MapList ml = new MapList(codons, protein, 3, 1);
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(1, 1)));
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInTo(3, 8)));
+ assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(2, 11)));
+ assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(3, 11)));
+
+ // we want base 12 to map to both of the amino acids it codes for
+ assertEquals("[4, 5]", Arrays.toString(ml.locateInTo(12, 12)));
+ assertEquals("[4, 5]", Arrays.toString(ml.locateInTo(11, 12)));
+ assertEquals("[4, 6]", Arrays.toString(ml.locateInTo(11, 15)));
+ assertEquals("[6, 6]", Arrays.toString(ml.locateInTo(15, 17)));
+
+ assertNull(ml.locateInTo(0, 0));
+ assertNull(ml.locateInTo(1, 18));
+ assertNull(ml.locateInTo(-1, 1));
+ }
+
+ @Test(groups = { "Functional" })
+ public void testTraverseToPosition()
+ {
+ List<int[]> ranges = new ArrayList<>();
+ assertNull(MapList.traverseToPosition(ranges, 0));
+
+ ranges.add(new int[] { 3, 6 });
+ assertNull(MapList.traverseToPosition(ranges, 0));
+ }