in progress
[jalview.git] / forester / java / src / org / forester / application / surfacing.java
index 8c8d4a0..a085c9d 100644 (file)
@@ -46,7 +46,7 @@ import java.util.TreeSet;
 
 import org.forester.evoinference.distance.NeighborJoining;
 import org.forester.evoinference.matrix.character.CharacterStateMatrix.Format;
-import org.forester.evoinference.matrix.distance.DistanceMatrix;
+import org.forester.evoinference.matrix.distance.BasicSymmetricalDistanceMatrix;
 import org.forester.go.GoId;
 import org.forester.go.GoNameSpace;
 import org.forester.go.GoTerm;
@@ -63,14 +63,17 @@ import org.forester.phylogeny.PhylogenyMethods;
 import org.forester.phylogeny.PhylogenyNode;
 import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;
 import org.forester.phylogeny.iterators.PhylogenyNodeIterator;
+import org.forester.protein.BinaryDomainCombination;
+import org.forester.protein.Domain;
+import org.forester.protein.DomainId;
+import org.forester.protein.Protein;
+import org.forester.species.BasicSpecies;
+import org.forester.species.Species;
 import org.forester.surfacing.BasicDomainSimilarityCalculator;
 import org.forester.surfacing.BasicGenomeWideCombinableDomains;
-import org.forester.surfacing.BasicSpecies;
-import org.forester.surfacing.BinaryDomainCombination;
 import org.forester.surfacing.CombinationsBasedPairwiseDomainSimilarityCalculator;
 import org.forester.surfacing.DomainCountsBasedPairwiseSimilarityCalculator;
 import org.forester.surfacing.DomainCountsDifferenceUtil;
-import org.forester.surfacing.DomainId;
 import org.forester.surfacing.DomainLengthsTable;
 import org.forester.surfacing.DomainParsimonyCalculator;
 import org.forester.surfacing.DomainSimilarity;
@@ -85,9 +88,7 @@ import org.forester.surfacing.PairwiseDomainSimilarityCalculator;
 import org.forester.surfacing.PairwiseGenomeComparator;
 import org.forester.surfacing.PrintableDomainSimilarity;
 import org.forester.surfacing.PrintableDomainSimilarity.PRINT_OPTION;
-import org.forester.surfacing.Protein;
 import org.forester.surfacing.ProteinCountsBasedPairwiseDomainSimilarityCalculator;
-import org.forester.surfacing.Species;
 import org.forester.surfacing.SurfacingUtil;
 import org.forester.util.BasicDescriptiveStatistics;
 import org.forester.util.BasicTable;
@@ -99,184 +100,193 @@ import org.forester.util.ForesterUtil;
 
 public class surfacing {
 
-    public final static String                                DOMAIN_COMBINITONS_OUTPUT_OPTION_FOR_GRAPH_ANALYSIS                    = "graph_analysis_out";
-    public final static String                                DOMAIN_COMBINITONS_OUTPUTFILE_SUFFIX_FOR_GRAPH_ANALYSIS                = "_dc.dot";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_BC_OUTPUTFILE_SUFFIX_FOR_GRAPH_ANALYSIS = "_fitch_present_dc.dot";
-    public final static String                                DOMAIN_COMBINITON_COUNTS_OUTPUTFILE_SUFFIX                             = ".dcc";
+    private static final int                                  MINIMAL_NUMBER_OF_SIMILARITIES_FOR_SPLITTING                                  = 1000;
+    public final static String                                DOMAIN_COMBINITONS_OUTPUT_OPTION_FOR_GRAPH_ANALYSIS                           = "graph_analysis_out";
+    public final static String                                DOMAIN_COMBINITONS_OUTPUTFILE_SUFFIX_FOR_GRAPH_ANALYSIS                       = "_dc.dot";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_BC_OUTPUTFILE_SUFFIX_FOR_GRAPH_ANALYSIS        = "_fitch_present_dc.dot";
+    public final static String                                DOMAIN_COMBINITON_COUNTS_OUTPUTFILE_SUFFIX                                    = ".dcc";
     // gain/loss:
-    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_DOMAINS                               = "_dollo_gl_d";
-    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_BINARY_COMBINATIONS                   = "_dollo_gl_dc";
-    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_FITCH_DOMAINS                               = "_fitch_gl_d";
-    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_FITCH_BINARY_COMBINATIONS                   = "_fitch_gl_dc";
+    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_DOMAINS                                      = "_dollo_gl_d";
+    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_BINARY_COMBINATIONS                          = "_dollo_gl_dc";
+    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_FITCH_DOMAINS                                      = "_fitch_gl_d";
+    public final static String                                PARSIMONY_OUTPUT_GL_SUFFIX_FITCH_BINARY_COMBINATIONS                          = "_fitch_gl_dc";
     // gain/loss counts:
-    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_DOMAINS                        = "_dollo_glc_d";
-    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_BINARY_COMBINATIONS            = "_dollo_glc_dc";
-    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_FITCH_DOMAINS                        = "_fitch_glc_d";
-    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_FITCH_BINARY_COMBINATIONS            = "_fitch_glc_dc";
+    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_DOMAINS                               = "_dollo_glc_d";
+    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_BINARY_COMBINATIONS                   = "_dollo_glc_dc";
+    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_FITCH_DOMAINS                               = "_fitch_glc_d";
+    public final static String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_FITCH_BINARY_COMBINATIONS                   = "_fitch_glc_dc";
     // tables:
-    public final static String                                PARSIMONY_OUTPUT_FITCH_GAINS_BC                                        = "_fitch_gains_dc";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_GAINS_HTML_BC                                   = "_fitch_gains_dc.html";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_LOSSES_BC                                       = "_fitch_losses_dc";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_LOSSES_HTML_BC                                  = "_fitch_losses_dc.html";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_BC                                      = "_fitch_present_dc";
-    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_HTML_BC                                 = "_fitch_present_dc.html";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_GAINS_D                                         = "_dollo_gains_d";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_GAINS_HTML_D                                    = "_dollo_gains_d.html";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_D                                        = "_dollo_losses_d";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_HTML_D                                   = "_dollo_losses_d.html";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_D                                       = "_dollo_present_d";
-    public final static String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_HTML_D                                  = "_dollo_present_d.html";
-    public final static String                                DOMAINS_PRESENT_NEXUS                                                  = "_dom.nex";
-    public final static String                                BDC_PRESENT_NEXUS                                                      = "_dc.nex";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_GAINS_BC                                               = "_fitch_gains_dc";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_GAINS_HTML_BC                                          = "_fitch_gains_dc.html";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_LOSSES_BC                                              = "_fitch_losses_dc";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_LOSSES_HTML_BC                                         = "_fitch_losses_dc.html";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_BC                                             = "_fitch_present_dc";
+    public final static String                                PARSIMONY_OUTPUT_FITCH_PRESENT_HTML_BC                                        = "_fitch_present_dc.html";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_GAINS_D                                                = "_dollo_gains_d";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_GAINS_HTML_D                                           = "_dollo_gains_d.html";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_D                                               = "_dollo_losses_d";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_HTML_D                                          = "_dollo_losses_d.html";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_D                                              = "_dollo_present_d";
+    public final static String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_HTML_D                                         = "_dollo_present_d.html";
+    public final static String                                DOMAINS_PRESENT_NEXUS                                                         = "_dom.nex";
+    public final static String                                BDC_PRESENT_NEXUS                                                             = "_dc.nex";
     // ---
-    public final static String                                PRG_NAME                                                               = "surfacing";
-    public static final String                                DOMAINS_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO                             = "_d_dollo"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    public static final String                                DOMAINS_PARSIMONY_TREE_OUTPUT_SUFFIX_FITCH                             = "_d_fitch"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    public static final String                                BINARY_DOMAIN_COMBINATIONS_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO          = "_dc_dollo"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    public static final String                                BINARY_DOMAIN_COMBINATIONS_PARSIMONY_TREE_OUTPUT_SUFFIX_FITCH          = "_dc_fitch"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    public static final String                                NEXUS_EXTERNAL_DOMAINS                                                 = "_dom.nex";
-    public static final String                                NEXUS_EXTERNAL_DOMAIN_COMBINATIONS                                     = "_dc.nex";
-    public static final String                                NEXUS_SECONDARY_FEATURES                                               = "_secondary_features.nex";
-    public static final String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_SECONDARY_FEATURES                    = "_dollo_gl_secondary_features";
-    public static final String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_SECONDARY_FEATURES             = "_dollo_glc_secondary_features";
-    public static final String                                PARSIMONY_OUTPUT_DOLLO_GAINS_SECONDARY_FEATURES                        = "_dollo_gains_secondary_features";
-    public static final String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_SECONDARY_FEATURES                       = "_dollo_losses_secondary_features";
-    public static final String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_SECONDARY_FEATURES                      = "_dollo_present_secondary_features";
-    public static final String                                SECONDARY_FEATURES_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO                  = "_secondary_features_dollo"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    public static final String                                PARSIMONY_OUTPUT_DOLLO_ALL_GOID_D_ALL_NAMESPACES                       = "_dollo_goid_d";
-    public static final String                                PARSIMONY_OUTPUT_FITCH_ALL_GOID_BC_ALL_NAMESPACES                      = "_fitch_goid_dc";
-    final static private String                               HELP_OPTION_1                                                          = "help";
-    final static private String                               HELP_OPTION_2                                                          = "h";
-    final static private String                               OUTPUT_DIR_OPTION                                                      = "out_dir";
-    final static private String                               SCORING_OPTION                                                         = "scoring";
-    private static final DomainSimilarityScoring              SCORING_DEFAULT                                                        = DomainSimilarity.DomainSimilarityScoring.COMBINATIONS;
-    final static private String                               SCORING_DOMAIN_COUNT_BASED                                             = "domains";
-    final static private String                               SCORING_PROTEIN_COUNT_BASED                                            = "proteins";
-    final static private String                               SCORING_COMBINATION_BASED                                              = "combinations";
-    final static private String                               DETAILEDNESS_OPTION                                                    = "detail";
-    private final static Detailedness                         DETAILEDNESS_DEFAULT                                                   = DomainSimilarityCalculator.Detailedness.PUNCTILIOUS;
-    final static private String                               SPECIES_MATRIX_OPTION                                                  = "smatrix";
-    final static private String                               DETAILEDNESS_BASIC                                                     = "basic";
-    final static private String                               DETAILEDNESS_LIST_IDS                                                  = "list_ids";
-    final static private String                               DETAILEDNESS_PUNCTILIOUS                                               = "punctilious";
-    final static private String                               DOMAIN_SIMILARITY_SORT_OPTION                                          = "sort";
-    private static final DomainSimilaritySortField            DOMAIN_SORT_FILD_DEFAULT                                               = DomainSimilarity.DomainSimilaritySortField.DOMAIN_ID;
-    final static private String                               DOMAIN_SIMILARITY_SORT_MIN                                             = "min";
-    final static private String                               DOMAIN_SIMILARITY_SORT_MAX                                             = "max";
-    final static private String                               DOMAIN_SIMILARITY_SORT_SD                                              = "sd";
-    final static private String                               DOMAIN_SIMILARITY_SORT_MEAN                                            = "mean";
-    final static private String                               DOMAIN_SIMILARITY_SORT_DIFF                                            = "diff";
-    final static private String                               DOMAIN_SIMILARITY_SORT_COUNTS_DIFF                                     = "count_diff";
-    final static private String                               DOMAIN_SIMILARITY_SORT_ABS_COUNTS_DIFF                                 = "abs_count_diff";
-    final static private String                               DOMAIN_SIMILARITY_SORT_SPECIES_COUNT                                   = "species";
-    final static private String                               DOMAIN_SIMILARITY_SORT_ALPHA                                           = "alpha";
-    final static private String                               DOMAIN_SIMILARITY_SORT_BY_SPECIES_COUNT_FIRST_OPTION                   = "species_first";
-    final static private String                               DOMAIN_COUNT_SORT_OPTION                                               = "dc_sort";
-    private static final GenomeWideCombinableDomainsSortOrder DOMAINS_SORT_ORDER_DEFAULT                                             = GenomeWideCombinableDomains.GenomeWideCombinableDomainsSortOrder.ALPHABETICAL_KEY_ID;
-    final static private String                               DOMAIN_COUNT_SORT_ALPHA                                                = "alpha";
-    final static private String                               DOMAIN_COUNT_SORT_KEY_DOMAIN_COUNT                                     = "dom";
-    final static private String                               DOMAIN_COUNT_SORT_KEY_DOMAIN_PROTEINS_COUNT                            = "prot";
-    final static private String                               DOMAIN_COUNT_SORT_COMBINATIONS_COUNT                                   = "comb";
-    final static private String                               CUTOFF_SCORE_FILE_OPTION                                               = "cos";
-    final static private String                               NOT_IGNORE_DUFS_OPTION                                                 = "dufs";
-    final static private String                               MAX_E_VALUE_OPTION                                                     = "e";
-    final static private String                               MAX_ALLOWED_OVERLAP_OPTION                                             = "mo";
-    final static private String                               NO_ENGULFING_OVERLAP_OPTION                                            = "no_eo";
-    final static private String                               IGNORE_COMBINATION_WITH_SAME_OPTION                                    = "ignore_self_comb";
-    final static private String                               PAIRWISE_DOMAIN_COMPARISONS_PREFIX                                     = "pwc_";
-    final static private String                               PAIRWISE_DOMAIN_COMPARISONS_OPTION                                     = "pwc";
-    final static private String                               OUTPUT_FILE_OPTION                                                     = "o";
-    final static private String                               PFAM_TO_GO_FILE_USE_OPTION                                             = "p2g";
-    final static private String                               GO_OBO_FILE_USE_OPTION                                                 = "obo";
-    final static private String                               GO_NAMESPACE_LIMIT_OPTION                                              = "go_namespace";
-    final static private String                               GO_NAMESPACE_LIMIT_OPTION_MOLECULAR_FUNCTION                           = "molecular_function";
-    final static private String                               GO_NAMESPACE_LIMIT_OPTION_BIOLOGICAL_PROCESS                           = "biological_process";
-    final static private String                               GO_NAMESPACE_LIMIT_OPTION_CELLULAR_COMPONENT                           = "cellular_component";
-    final static private String                               SECONDARY_FEATURES_PARSIMONY_MAP_FILE                                  = "secondary";
-    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_SIMPLE_TAB_DELIMITED                    = "simple_tab";
-    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_SIMPLE_HTML                             = "simple_html";
-    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_DETAILED_HTML                           = "detailed_html";
-    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION                                         = "ds_output";
-    private static final PRINT_OPTION                         DOMAIN_SIMILARITY_PRINT_OPTION_DEFAULT                                 = PrintableDomainSimilarity.PRINT_OPTION.HTML;
-    final static private String                               IGNORE_DOMAINS_WITHOUT_COMBINATIONS_IN_ALL_SPECIES_OPTION              = "ignore_singlet_domains";
-    final static private String                               IGNORE_VIRAL_IDS                                                       = "ignore_viral_ids";
-    final static private boolean                              IGNORE_DOMAINS_WITHOUT_COMBINATIONS_IN_ALL_SPECIES_DEFAULT             = false;
-    final static private String                               IGNORE_DOMAINS_SPECIFIC_TO_ONE_SPECIES_OPTION                          = "ignore_species_specific_domains";
-    final static private boolean                              IGNORE_DOMAINS_SPECIFIC_TO_ONE_SPECIES_OPTION_DEFAULT                  = false;
-    final static private String                               MATRIX_MEAN_SCORE_BASED_GENOME_DISTANCE_SUFFIX                         = "_mean_score.pwd";
-    final static private String                               MATRIX_SHARED_DOMAINS_BASED_GENOME_DISTANCE_SUFFIX                     = "_domains.pwd";
-    final static private String                               MATRIX_SHARED_BIN_COMBINATIONS_BASED_GENOME_DISTANCE_SUFFIX            = "_bin_combinations.pwd";
-    final static private String                               NJ_TREE_MEAN_SCORE_BASED_GENOME_DISTANCE_SUFFIX                        = "_mean_score_NJ"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    final static private String                               NJ_TREE_SHARED_DOMAINS_BASED_GENOME_DISTANCE_SUFFIX                    = "_domains_NJ"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    final static private String                               NJ_TREE_SHARED_BIN_COMBINATIONS_BASED_GENOME_DISTANCE_SUFFIX           = "_bin_combinations_NJ"
-                                                                                                                                             + ForesterConstants.PHYLO_XML_SUFFIX;
-    final static private String                               JACKNIFE_OPTION                                                        = "jack";
-    final static private String                               JACKNIFE_RANDOM_SEED_OPTION                                            = "seed";
-    final static private String                               JACKNIFE_RATIO_OPTION                                                  = "jack_ratio";
-    private static final int                                  JACKNIFE_NUMBER_OF_RESAMPLINGS_DEFAULT                                 = 100;
-    final static private long                                 JACKNIFE_RANDOM_SEED_DEFAULT                                           = 19;
-    final static private double                               JACKNIFE_RATIO_DEFAULT                                                 = 0.5;
+    public final static String                                PRG_NAME                                                                      = "surfacing";
+    public static final String                                DOMAINS_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO                                    = "_d_dollo"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                DOMAINS_PARSIMONY_TREE_OUTPUT_SUFFIX_FITCH                                    = "_d_fitch"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                BINARY_DOMAIN_COMBINATIONS_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO                 = "_dc_dollo"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                BINARY_DOMAIN_COMBINATIONS_PARSIMONY_TREE_OUTPUT_SUFFIX_FITCH                 = "_dc_fitch"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                NEXUS_EXTERNAL_DOMAINS                                                        = "_dom.nex";
+    public static final String                                NEXUS_EXTERNAL_DOMAIN_COMBINATIONS                                            = "_dc.nex";
+    public static final String                                NEXUS_SECONDARY_FEATURES                                                      = "_secondary_features.nex";
+    public static final String                                PARSIMONY_OUTPUT_GL_SUFFIX_DOLLO_SECONDARY_FEATURES                           = "_dollo_gl_secondary_features";
+    public static final String                                PARSIMONY_OUTPUT_GL_COUNTS_SUFFIX_DOLLO_SECONDARY_FEATURES                    = "_dollo_glc_secondary_features";
+    public static final String                                PARSIMONY_OUTPUT_DOLLO_GAINS_SECONDARY_FEATURES                               = "_dollo_gains_secondary_features";
+    public static final String                                PARSIMONY_OUTPUT_DOLLO_LOSSES_SECONDARY_FEATURES                              = "_dollo_losses_secondary_features";
+    public static final String                                PARSIMONY_OUTPUT_DOLLO_PRESENT_SECONDARY_FEATURES                             = "_dollo_present_secondary_features";
+    public static final String                                SECONDARY_FEATURES_PARSIMONY_TREE_OUTPUT_SUFFIX_DOLLO                         = "_secondary_features_dollo"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                PARSIMONY_OUTPUT_DOLLO_ALL_GOID_D_ALL_NAMESPACES                              = "_dollo_goid_d";
+    public static final String                                PARSIMONY_OUTPUT_FITCH_ALL_GOID_BC_ALL_NAMESPACES                             = "_fitch_goid_dc";
+    final static private String                               HELP_OPTION_1                                                                 = "help";
+    final static private String                               HELP_OPTION_2                                                                 = "h";
+    final static private String                               OUTPUT_DIR_OPTION                                                             = "out_dir";
+    final static private String                               SCORING_OPTION                                                                = "scoring";
+    private static final DomainSimilarityScoring              SCORING_DEFAULT                                                               = DomainSimilarity.DomainSimilarityScoring.COMBINATIONS;
+    final static private String                               SCORING_DOMAIN_COUNT_BASED                                                    = "domains";
+    final static private String                               SCORING_PROTEIN_COUNT_BASED                                                   = "proteins";
+    final static private String                               SCORING_COMBINATION_BASED                                                     = "combinations";
+    final static private String                               DETAILEDNESS_OPTION                                                           = "detail";
+    private final static Detailedness                         DETAILEDNESS_DEFAULT                                                          = DomainSimilarityCalculator.Detailedness.PUNCTILIOUS;
+    final static private String                               SPECIES_MATRIX_OPTION                                                         = "smatrix";
+    final static private String                               DETAILEDNESS_BASIC                                                            = "basic";
+    final static private String                               DETAILEDNESS_LIST_IDS                                                         = "list_ids";
+    final static private String                               DETAILEDNESS_PUNCTILIOUS                                                      = "punctilious";
+    final static private String                               DOMAIN_SIMILARITY_SORT_OPTION                                                 = "sort";
+    private static final DomainSimilaritySortField            DOMAIN_SORT_FILD_DEFAULT                                                      = DomainSimilarity.DomainSimilaritySortField.DOMAIN_ID;
+    final static private String                               DOMAIN_SIMILARITY_SORT_MIN                                                    = "min";
+    final static private String                               DOMAIN_SIMILARITY_SORT_MAX                                                    = "max";
+    final static private String                               DOMAIN_SIMILARITY_SORT_SD                                                     = "sd";
+    final static private String                               DOMAIN_SIMILARITY_SORT_MEAN                                                   = "mean";
+    final static private String                               DOMAIN_SIMILARITY_SORT_DIFF                                                   = "diff";
+    final static private String                               DOMAIN_SIMILARITY_SORT_COUNTS_DIFF                                            = "count_diff";
+    final static private String                               DOMAIN_SIMILARITY_SORT_ABS_COUNTS_DIFF                                        = "abs_count_diff";
+    final static private String                               DOMAIN_SIMILARITY_SORT_SPECIES_COUNT                                          = "species";
+    final static private String                               DOMAIN_SIMILARITY_SORT_ALPHA                                                  = "alpha";
+    final static private String                               DOMAIN_SIMILARITY_SORT_BY_SPECIES_COUNT_FIRST_OPTION                          = "species_first";
+    final static private String                               DOMAIN_COUNT_SORT_OPTION                                                      = "dc_sort";
+    private static final GenomeWideCombinableDomainsSortOrder DOMAINS_SORT_ORDER_DEFAULT                                                    = GenomeWideCombinableDomains.GenomeWideCombinableDomainsSortOrder.ALPHABETICAL_KEY_ID;
+    final static private String                               DOMAIN_COUNT_SORT_ALPHA                                                       = "alpha";
+    final static private String                               DOMAIN_COUNT_SORT_KEY_DOMAIN_COUNT                                            = "dom";
+    final static private String                               DOMAIN_COUNT_SORT_KEY_DOMAIN_PROTEINS_COUNT                                   = "prot";
+    final static private String                               DOMAIN_COUNT_SORT_COMBINATIONS_COUNT                                          = "comb";
+    final static private String                               CUTOFF_SCORE_FILE_OPTION                                                      = "cos";
+    final static private String                               NOT_IGNORE_DUFS_OPTION                                                        = "dufs";
+    final static private String                               MAX_E_VALUE_OPTION                                                            = "e";
+    final static private String                               MAX_ALLOWED_OVERLAP_OPTION                                                    = "mo";
+    final static private String                               NO_ENGULFING_OVERLAP_OPTION                                                   = "no_eo";
+    final static private String                               IGNORE_COMBINATION_WITH_SAME_OPTION                                           = "ignore_self_comb";
+    final static private String                               PAIRWISE_DOMAIN_COMPARISONS_PREFIX                                            = "pwc_";
+    final static private String                               PAIRWISE_DOMAIN_COMPARISONS_OPTION                                            = "pwc";
+    final static private String                               OUTPUT_FILE_OPTION                                                            = "o";
+    final static private String                               PFAM_TO_GO_FILE_USE_OPTION                                                    = "p2g";
+    final static private String                               GO_OBO_FILE_USE_OPTION                                                        = "obo";
+    final static private String                               GO_NAMESPACE_LIMIT_OPTION                                                     = "go_namespace";
+    final static private String                               GO_NAMESPACE_LIMIT_OPTION_MOLECULAR_FUNCTION                                  = "molecular_function";
+    final static private String                               GO_NAMESPACE_LIMIT_OPTION_BIOLOGICAL_PROCESS                                  = "biological_process";
+    final static private String                               GO_NAMESPACE_LIMIT_OPTION_CELLULAR_COMPONENT                                  = "cellular_component";
+    final static private String                               SECONDARY_FEATURES_PARSIMONY_MAP_FILE                                         = "secondary";
+    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_SIMPLE_TAB_DELIMITED                           = "simple_tab";
+    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_SIMPLE_HTML                                    = "simple_html";
+    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION_DETAILED_HTML                                  = "detailed_html";
+    final static private String                               DOMAIN_SIMILARITY_PRINT_OPTION                                                = "ds_output";
+    private static final PRINT_OPTION                         DOMAIN_SIMILARITY_PRINT_OPTION_DEFAULT                                        = PrintableDomainSimilarity.PRINT_OPTION.HTML;
+    final static private String                               IGNORE_DOMAINS_WITHOUT_COMBINATIONS_IN_ALL_SPECIES_OPTION                     = "ignore_singlet_domains";
+    final static private String                               IGNORE_VIRAL_IDS                                                              = "ignore_viral_ids";
+    final static private boolean                              IGNORE_DOMAINS_WITHOUT_COMBINATIONS_IN_ALL_SPECIES_DEFAULT                    = false;
+    final static private String                               IGNORE_DOMAINS_SPECIFIC_TO_ONE_SPECIES_OPTION                                 = "ignore_species_specific_domains";
+    final static private boolean                              IGNORE_DOMAINS_SPECIFIC_TO_ONE_SPECIES_OPTION_DEFAULT                         = false;
+    final static private String                               MATRIX_MEAN_SCORE_BASED_GENOME_DISTANCE_SUFFIX                                = "_mean_score.pwd";
+    final static private String                               MATRIX_SHARED_DOMAINS_BASED_GENOME_DISTANCE_SUFFIX                            = "_domains.pwd";
+    final static private String                               MATRIX_SHARED_BIN_COMBINATIONS_BASED_GENOME_DISTANCE_SUFFIX                   = "_bin_combinations.pwd";
+    final static private String                               NJ_TREE_MEAN_SCORE_BASED_GENOME_DISTANCE_SUFFIX                               = "_mean_score_NJ"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    final static private String                               NJ_TREE_SHARED_DOMAINS_BASED_GENOME_DISTANCE_SUFFIX                           = "_domains_NJ"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    final static private String                               NJ_TREE_SHARED_BIN_COMBINATIONS_BASED_GENOME_DISTANCE_SUFFIX                  = "_bin_combinations_NJ"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    final static private String                               JACKNIFE_OPTION                                                               = "jack";
+    final static private String                               JACKNIFE_RANDOM_SEED_OPTION                                                   = "seed";
+    final static private String                               JACKNIFE_RATIO_OPTION                                                         = "jack_ratio";
+    private static final int                                  JACKNIFE_NUMBER_OF_RESAMPLINGS_DEFAULT                                        = 100;
+    final static private long                                 JACKNIFE_RANDOM_SEED_DEFAULT                                                  = 19;
+    final static private double                               JACKNIFE_RATIO_DEFAULT                                                        = 0.5;
     //final static private String  INFER_SPECIES_TREES_OPTION                                             = "species_tree_inference";
-    final static private String                               INFERRED_SD_BASED_NJ_SPECIES_TREE_SUFFIX                               = "_sd_nj.nh";
-    final static private String                               INFERRED_SBC_BASED_NJ_SPECIES_TREE_SUFFIX                              = "_sbc_nj.nh";
-    final static private String                               FILTER_POSITIVE_OPTION                                                 = "pos_filter";
-    final static private String                               FILTER_NEGATIVE_OPTION                                                 = "neg_filter";
-    final static private String                               FILTER_NEGATIVE_DOMAINS_OPTION                                         = "neg_dom_filter";
-    final static private String                               INPUT_FILES_FROM_FILE_OPTION                                           = "input";
-    final static private String                               INPUT_SPECIES_TREE_OPTION                                              = "species_tree";
-    final static private String                               SEQ_EXTRACT_OPTION                                                     = "prot_extract";
-    final static private char                                 SEPARATOR_FOR_INPUT_VALUES                                             = '#';
-    final static private String                               PRG_VERSION                                                            = "2.210";
-    final static private String                               PRG_DATE                                                               = "2011.12.08";
-    final static private String                               E_MAIL                                                                 = "czmasek@burnham.org";
-    final static private String                               WWW                                                                    = "www.phylosoft.org/forester/applications/surfacing";
-    final static private boolean                              IGNORE_DUFS_DEFAULT                                                    = true;
-    final static private boolean                              IGNORE_COMBINATION_WITH_SAME_DEFAULLT                                  = false;
-    final static private double                               MAX_E_VALUE_DEFAULT                                                    = -1;
-    final static private int                                  MAX_ALLOWED_OVERLAP_DEFAULT                                            = -1;
-    private static final String                               RANDOM_SEED_FOR_FITCH_PARSIMONY_OPTION                                 = "random_seed";
-    private static final String                               CONSIDER_DOMAIN_COMBINATION_DIRECTEDNESS                               = "consider_bdc_direction";
-    private static final String                               CONSIDER_DOMAIN_COMBINATION_DIRECTEDNESS_AND_ADJACENCY                 = "consider_bdc_adj";
-    private static final String                               SEQ_EXTRACT_SUFFIX                                                     = ".prot";
-    private static final String                               PLUS_MINUS_ANALYSIS_OPTION                                             = "plus_minus";
-    private static final String                               PLUS_MINUS_DOM_SUFFIX                                                  = "_plus_minus_dom.txt";
-    private static final String                               PLUS_MINUS_DOM_SUFFIX_HTML                                             = "_plus_minus_dom.html";
-    private static final String                               PLUS_MINUS_DC_SUFFIX_HTML                                              = "_plus_minus_dc.html";
-    private static final int                                  PLUS_MINUS_ANALYSIS_MIN_DIFF_DEFAULT                                   = 0;
-    private static final double                               PLUS_MINUS_ANALYSIS_FACTOR_DEFAULT                                     = 1.0;
-    private static final String                               PLUS_MINUS_ALL_GO_IDS_DOM_SUFFIX                                       = "_plus_minus_go_ids_all.txt";
-    private static final String                               PLUS_MINUS_PASSING_GO_IDS_DOM_SUFFIX                                   = "_plus_minus_go_ids_passing.txt";
-    private static final String                               OUTPUT_LIST_OF_ALL_PROTEINS_OPTIONS                                    = "all_prot";
-    private static final boolean                              VERBOSE                                                                = false;
-    private static final String                               OUTPUT_DOMAIN_COMBINATIONS_GAINED_MORE_THAN_ONCE_ANALYSIS_SUFFIX       = "_fitch_dc_gains_counts";
-    private static final String                               OUTPUT_DOMAIN_COMBINATIONS_LOST_MORE_THAN_ONCE_ANALYSIS_SUFFIX         = "_fitch_dc_losses_counts";
-    private static final String                               DOMAIN_LENGTHS_ANALYSIS_SUFFIX                                         = "_domain_lengths_analysis";
-    private static final boolean                              PERFORM_DOMAIN_LENGTH_ANALYSIS                                         = true;
-    public static final String                                ALL_PFAMS_ENCOUNTERED_SUFFIX                                           = "_all_encountered_pfams";
-    public static final String                                ALL_PFAMS_ENCOUNTERED_WITH_GO_ANNOTATION_SUFFIX                        = "_all_encountered_pfams_with_go_annotation";
-    public static final String                                ENCOUNTERED_PFAMS_SUMMARY_SUFFIX                                       = "_encountered_pfams_summary";
-    public static final String                                ALL_PFAMS_GAINED_AS_DOMAINS_SUFFIX                                     = "_all_pfams_gained_as_domains";
-    public static final String                                ALL_PFAMS_LOST_AS_DOMAINS_SUFFIX                                       = "_all_pfams_lost_as_domains";
-    public static final String                                ALL_PFAMS_GAINED_AS_DC_SUFFIX                                          = "_all_pfams_gained_as_dc";
-    public static final String                                ALL_PFAMS_LOST_AS_DC_SUFFIX                                            = "_all_pfams_lost_as_dc";
-    public static final String                                BASE_DIRECTORY_PER_NODE_DOMAIN_GAIN_LOSS_FILES                         = "PER_NODE_EVENTS";
-    public static final String                                BASE_DIRECTORY_PER_SUBTREE_DOMAIN_GAIN_LOSS_FILES                      = "PER_SUBTREE_EVENTS";
-    public static final String                                D_PROMISCUITY_FILE_SUFFIX                                              = "_domain_promiscuities";
-    private static final String                               LOG_FILE_SUFFIX                                                        = "_log.txt";
-    private static final String                               DATA_FILE_SUFFIX                                                       = "_domain_combination_data.txt";
-    private static final String                               DATA_FILE_DESC                                                         = "#SPECIES\tPRTEIN_ID\tN_TERM_DOMAIN\tC_TERM_DOMAIN\tN_TERM_DOMAIN_PER_DOMAIN_E_VALUE\tC_TERM_DOMAIN_PER_DOMAIN_E_VALUE\tN_TERM_DOMAIN_COUNTS_PER_PROTEIN\tC_TERM_DOMAIN_COUNTS_PER_PROTEIN";
-    private static final INDIVIDUAL_SCORE_CUTOFF              INDIVIDUAL_SCORE_CUTOFF_DEFAULT                                        = INDIVIDUAL_SCORE_CUTOFF.FULL_SEQUENCE;
-    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_COUNTS_OUTPUT_SUFFIX                   = "_indep_dc_gains_fitch_counts.txt";
-    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_OUTPUT_SUFFIX                       = "_indep_dc_gains_fitch_lists.txt";
-    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_OUTPUT_SUFFIX        = "_indep_dc_gains_fitch_lists_for_go_mapping.txt";
-    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_OUTPUT_UNIQUE_SUFFIX = "_indep_dc_gains_fitch_lists_for_go_mapping_unique.txt";
+    final static private String                               INFERRED_SD_BASED_NJ_SPECIES_TREE_SUFFIX                                      = "_sd_nj.nh";
+    final static private String                               INFERRED_SBC_BASED_NJ_SPECIES_TREE_SUFFIX                                     = "_sbc_nj.nh";
+    final static private String                               FILTER_POSITIVE_OPTION                                                        = "pos_filter";
+    final static private String                               FILTER_NEGATIVE_OPTION                                                        = "neg_filter";
+    final static private String                               FILTER_NEGATIVE_DOMAINS_OPTION                                                = "neg_dom_filter";
+    final static private String                               INPUT_FILES_FROM_FILE_OPTION                                                  = "input";
+    final static private String                               INPUT_SPECIES_TREE_OPTION                                                     = "species_tree";
+    final static private String                               SEQ_EXTRACT_OPTION                                                            = "prot_extract";
+    final static private char                                 SEPARATOR_FOR_INPUT_VALUES                                                    = '#';
+    final static private String                               PRG_VERSION                                                                   = "2.250";
+    final static private String                               PRG_DATE                                                                      = "2012.05.07";
+    final static private String                               E_MAIL                                                                        = "czmasek@burnham.org";
+    final static private String                               WWW                                                                           = "www.phylosoft.org/forester/applications/surfacing";
+    final static private boolean                              IGNORE_DUFS_DEFAULT                                                           = true;
+    final static private boolean                              IGNORE_COMBINATION_WITH_SAME_DEFAULLT                                         = false;
+    final static private double                               MAX_E_VALUE_DEFAULT                                                           = -1;
+    final static private int                                  MAX_ALLOWED_OVERLAP_DEFAULT                                                   = -1;
+    private static final String                               RANDOM_SEED_FOR_FITCH_PARSIMONY_OPTION                                        = "random_seed";
+    private static final String                               CONSIDER_DOMAIN_COMBINATION_DIRECTEDNESS                                      = "consider_bdc_direction";
+    private static final String                               CONSIDER_DOMAIN_COMBINATION_DIRECTEDNESS_AND_ADJACENCY                        = "consider_bdc_adj";
+    private static final String                               SEQ_EXTRACT_SUFFIX                                                            = ".prot";
+    private static final String                               PLUS_MINUS_ANALYSIS_OPTION                                                    = "plus_minus";
+    private static final String                               PLUS_MINUS_DOM_SUFFIX                                                         = "_plus_minus_dom.txt";
+    private static final String                               PLUS_MINUS_DOM_SUFFIX_HTML                                                    = "_plus_minus_dom.html";
+    private static final String                               PLUS_MINUS_DC_SUFFIX_HTML                                                     = "_plus_minus_dc.html";
+    private static final int                                  PLUS_MINUS_ANALYSIS_MIN_DIFF_DEFAULT                                          = 0;
+    private static final double                               PLUS_MINUS_ANALYSIS_FACTOR_DEFAULT                                            = 1.0;
+    private static final String                               PLUS_MINUS_ALL_GO_IDS_DOM_SUFFIX                                              = "_plus_minus_go_ids_all.txt";
+    private static final String                               PLUS_MINUS_PASSING_GO_IDS_DOM_SUFFIX                                          = "_plus_minus_go_ids_passing.txt";
+    private static final String                               OUTPUT_LIST_OF_ALL_PROTEINS_OPTIONS                                           = "all_prot";
+    private static final boolean                              VERBOSE                                                                       = false;
+    private static final String                               OUTPUT_DOMAIN_COMBINATIONS_GAINED_MORE_THAN_ONCE_ANALYSIS_SUFFIX              = "_fitch_dc_gains_counts";
+    private static final String                               OUTPUT_DOMAIN_COMBINATIONS_LOST_MORE_THAN_ONCE_ANALYSIS_SUFFIX                = "_fitch_dc_losses_counts";
+    private static final String                               DOMAIN_LENGTHS_ANALYSIS_SUFFIX                                                = "_domain_lengths_analysis";
+    private static final boolean                              PERFORM_DOMAIN_LENGTH_ANALYSIS                                                = true;
+    public static final String                                ALL_PFAMS_ENCOUNTERED_SUFFIX                                                  = "_all_encountered_pfams";
+    public static final String                                ALL_PFAMS_ENCOUNTERED_WITH_GO_ANNOTATION_SUFFIX                               = "_all_encountered_pfams_with_go_annotation";
+    public static final String                                ENCOUNTERED_PFAMS_SUMMARY_SUFFIX                                              = "_encountered_pfams_summary";
+    public static final String                                ALL_PFAMS_GAINED_AS_DOMAINS_SUFFIX                                            = "_all_pfams_gained_as_domains";
+    public static final String                                ALL_PFAMS_LOST_AS_DOMAINS_SUFFIX                                              = "_all_pfams_lost_as_domains";
+    public static final String                                ALL_PFAMS_GAINED_AS_DC_SUFFIX                                                 = "_all_pfams_gained_as_dc";
+    public static final String                                ALL_PFAMS_LOST_AS_DC_SUFFIX                                                   = "_all_pfams_lost_as_dc";
+    public static final String                                BASE_DIRECTORY_PER_NODE_DOMAIN_GAIN_LOSS_FILES                                = "PER_NODE_EVENTS";
+    public static final String                                BASE_DIRECTORY_PER_SUBTREE_DOMAIN_GAIN_LOSS_FILES                             = "PER_SUBTREE_EVENTS";
+    public static final String                                D_PROMISCUITY_FILE_SUFFIX                                                     = "_domain_promiscuities";
+    private static final String                               LOG_FILE_SUFFIX                                                               = "_log.txt";
+    private static final String                               DATA_FILE_SUFFIX                                                              = "_domain_combination_data.txt";
+    private static final String                               DATA_FILE_DESC                                                                = "#SPECIES\tPRTEIN_ID\tN_TERM_DOMAIN\tC_TERM_DOMAIN\tN_TERM_DOMAIN_PER_DOMAIN_E_VALUE\tC_TERM_DOMAIN_PER_DOMAIN_E_VALUE\tN_TERM_DOMAIN_COUNTS_PER_PROTEIN\tC_TERM_DOMAIN_COUNTS_PER_PROTEIN";
+    private static final INDIVIDUAL_SCORE_CUTOFF              INDIVIDUAL_SCORE_CUTOFF_DEFAULT                                               = INDIVIDUAL_SCORE_CUTOFF.FULL_SEQUENCE;
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_COUNTS_OUTPUT_SUFFIX                          = "_indep_dc_gains_fitch_counts.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_OUTPUT_SUFFIX                              = "_indep_dc_gains_fitch_lists.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_OUTPUT_SUFFIX               = "_indep_dc_gains_fitch_lists_for_go_mapping.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_OUTPUT_UNIQUE_SUFFIX        = "_indep_dc_gains_fitch_lists_for_go_mapping_unique.txt";
+    public static final String                                LIMIT_SPEC_FOR_PROT_EX                                                        = null;                                                                                                                                                                                       // e.g. "HUMAN"; set to null for not using this feature (default).
+    public static final String                                BINARY_DOMAIN_COMBINATIONS_PARSIMONY_TREE_OUTPUT_SUFFIX_FITCH_MAPPED          = "_dc_MAPPED_secondary_features_fitch"
+                                                                                                                                                    + ForesterConstants.PHYLO_XML_SUFFIX;
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_COUNTS_MAPPED_OUTPUT_SUFFIX                   = "_indep_dc_gains_fitch_counts_MAPPED.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_MAPPED_OUTPUT_SUFFIX                       = "_indep_dc_gains_fitch_lists_MAPPED.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_MAPPED_OUTPUT_SUFFIX        = "_indep_dc_gains_fitch_lists_for_go_mapping_MAPPED.txt";
+    public static final String                                INDEPENDENT_DC_GAINS_FITCH_PARS_DC_FOR_GO_MAPPING_MAPPED_OUTPUT_UNIQUE_SUFFIX = "_indep_dc_gains_fitch_lists_for_go_mapping_unique_MAPPED.txt";
+    private static final boolean                              PERFORM_DC_REGAIN_PROTEINS_STATS                                              = true;
 
     private static void checkWriteabilityForPairwiseComparisons( final PrintableDomainSimilarity.PRINT_OPTION domain_similarity_print_option,
                                                                  final String[][] input_file_properties,
@@ -350,6 +360,7 @@ public class surfacing {
      * @param sum_of_all_domains_encountered
      * @param all_bin_domain_combinations_encountered
      * @param is_gains_analysis
+     * @param protein_length_stats_by_dc 
      * @throws IOException
      */
     private static void executeFitchGainsAnalysis( final File output_file,
@@ -535,7 +546,8 @@ public class surfacing {
         return intrees;
     }
 
-    private static List<Phylogeny> inferSpeciesTrees( final File outfile, final List<DistanceMatrix> distances_list ) {
+    private static List<Phylogeny> inferSpeciesTrees( final File outfile,
+                                                      final List<BasicSymmetricalDistanceMatrix> distances_list ) {
         final NeighborJoining nj = NeighborJoining.createInstance();
         final List<Phylogeny> phylogenies = nj.execute( distances_list );
         final PhylogenyWriter w = new PhylogenyWriter();
@@ -1404,7 +1416,6 @@ public class surfacing {
         System.out.println( "Ignore combination with self: " + ignore_combination_with_same );
         html_desc.append( "<tr><td>Ignore combination with self for domain combination similarity analyses:</td><td>"
                 + ignore_combination_with_same + "</td></tr>" + nl );
-        ;
         System.out.println( "Consider directedness       : "
                 + ( dc_type != BinaryDomainCombination.DomainCombinationType.BASIC ) );
         html_desc.append( "<tr><td>Consider directedness of binary domain combinations:</td><td>"
@@ -1751,6 +1762,13 @@ public class surfacing {
         catch ( final IOException e3 ) {
             e3.printStackTrace();
         }
+        Map<String, DescriptiveStatistics> protein_length_stats_by_dc = null;
+        Map<String, DescriptiveStatistics> domain_number_stats_by_dc = null;
+        final Map<String, DescriptiveStatistics> domain_length_stats_by_domain = new HashMap<String, DescriptiveStatistics>();
+        if ( PERFORM_DC_REGAIN_PROTEINS_STATS ) {
+            protein_length_stats_by_dc = new HashMap<String, DescriptiveStatistics>();
+            domain_number_stats_by_dc = new HashMap<String, DescriptiveStatistics>();
+        }
         // Main loop:
         for( int i = 0; i < number_of_genomes; ++i ) {
             System.out.println();
@@ -1901,6 +1919,13 @@ public class surfacing {
                     dc_data_writer.write( SurfacingUtil.proteinToDomainCombinations( protein, count + "", "\t" )
                             .toString() );
                     ++count;
+                    for( final Domain d : protein.getProteinDomains() ) {
+                        final String d_str = d.getDomainId().toString();
+                        if ( !domain_length_stats_by_domain.containsKey( d_str ) ) {
+                            domain_length_stats_by_domain.put( d_str, new BasicDescriptiveStatistics() );
+                        }
+                        domain_length_stats_by_domain.get( d_str ).addValue( d.getLength() );
+                    }
                 }
             }
             catch ( final IOException e ) {
@@ -1919,7 +1944,9 @@ public class surfacing {
                                      ignore_combination_with_same,
                                      new BasicSpecies( input_file_properties[ i ][ 1 ] ),
                                      domain_id_to_go_ids_map,
-                                     dc_type ) );
+                                     dc_type,
+                                     protein_length_stats_by_dc,
+                                     domain_number_stats_by_dc ) );
             domain_lengths_table.addLengths( protein_list );
             if ( gwcd_list.get( i ).getSize() > 0 ) {
                 SurfacingUtil.writeDomainCombinationsCountsFile( input_file_properties,
@@ -1945,7 +1972,8 @@ public class surfacing {
                         SurfacingUtil.extractProteinNames( protein_list,
                                                            query_domain_ids_array[ j ],
                                                            query_domains_writer_ary[ j ],
-                                                           "\t" );
+                                                           "\t",
+                                                           LIMIT_SPEC_FOR_PROT_EX );
                         query_domains_writer_ary[ j ].flush();
                     }
                     catch ( final IOException e ) {
@@ -2076,7 +2104,7 @@ public class surfacing {
             String my_outfile = output_file.toString();
             Map<Character, Writer> split_writers = null;
             Writer writer = null;
-            if ( similarities.size() > 1000  ) {
+            if ( similarities.size() > MINIMAL_NUMBER_OF_SIMILARITIES_FOR_SPLITTING ) {
                 if ( my_outfile.endsWith( ".html" ) ) {
                     my_outfile = my_outfile.substring( 0, my_outfile.length() - 5 );
                 }
@@ -2246,7 +2274,10 @@ public class surfacing {
                                                         output_binary_domain_combinationsfor_graph_analysis,
                                                         all_bin_domain_combinations_gained_fitch,
                                                         all_bin_domain_combinations_lost_fitch,
-                                                        dc_type );
+                                                        dc_type,
+                                                        protein_length_stats_by_dc,
+                                                        domain_number_stats_by_dc,
+                                                        domain_length_stats_by_domain );
                 // Listing of all domain combinations gained is only done if only one input tree is used. 
                 if ( ( domain_id_to_secondary_features_maps != null )
                         && ( domain_id_to_secondary_features_maps.length > 0 ) ) {
@@ -2361,47 +2392,74 @@ public class surfacing {
         final Runtime rt = java.lang.Runtime.getRuntime();
         final long free_memory = rt.freeMemory() / 1000000;
         final long total_memory = rt.totalMemory() / 1000000;
-        System.out.println();
-        System.out.println( "Time for analysis : " + ( new Date().getTime() - analysis_start_time ) + "ms" );
-        System.out.println( "Total running time: " + ( new Date().getTime() - start_time ) + "ms " );
-        System.out.println( "Free memory       : " + free_memory + "MB, total memory: " + total_memory + "MB" );
-        System.out.println();
-        System.out.println( "If this application is useful to you, please cite:" );
-        System.out.println( surfacing.WWW );
-        System.out.println();
+        ForesterUtil.programMessage( PRG_NAME, "Time for analysis : " + ( new Date().getTime() - analysis_start_time )
+                + "ms" );
+        ForesterUtil.programMessage( PRG_NAME, "Total running time: " + ( new Date().getTime() - start_time ) + "ms " );
+        ForesterUtil.programMessage( PRG_NAME, "Free memory       : " + free_memory + "MB, total memory: "
+                + total_memory + "MB" );
+        ForesterUtil.programMessage( PRG_NAME, "If this application is useful to you, please cite:" );
+        ForesterUtil.programMessage( PRG_NAME, surfacing.WWW );
         ForesterUtil.programMessage( PRG_NAME, "OK" );
         System.out.println();
     }
 
-    private static void createSplitWriters( File out_dir, String my_outfile, Map<Character, Writer> split_writers )
-            throws IOException {
-        split_writers.put( 'a', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_A.html"  ) ) );
-        split_writers.put( 'b', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_B.html"  ) ) );
-        split_writers.put( 'c', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_C.html"  ) ) );
-        split_writers.put( 'd', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_D.html"  ) ) );
-        split_writers.put( 'e', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_E.html"  ) ) );
-        split_writers.put( 'f', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_F.html"  ) ) );
-        split_writers.put( 'g', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_G.html"  ) ) );
-        split_writers.put( 'h', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_H.html"  ) ) );
-        split_writers.put( 'i', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_I.html"  ) ) );
-        split_writers.put( 'j', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_J.html"  ) ) );
-        split_writers.put( 'k', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_K.html"  ) ) );
-        split_writers.put( 'l', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_L.html"  ) ) );
-        split_writers.put( 'm', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_M.html"  ) ) );
-        split_writers.put( 'n', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_N.html"  ) ) );
-        split_writers.put( 'o', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_O.html"  ) ) );
-        split_writers.put( 'p', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_P.html"  ) ) );
-        split_writers.put( 'q', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_Q.html"  ) ) );
-        split_writers.put( 'r', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_R.html"  ) ) );
-        split_writers.put( 's', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_S.html"  ) ) );
-        split_writers.put( 't', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_T.html"  ) ) );
-        split_writers.put( 'u', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_U.html"  ) ) );
-        split_writers.put( 'v', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_V.html"  ) ) );
-        split_writers.put( 'w', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_W.html"  ) ) );
-        split_writers.put( 'x', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_X.html"  ) ) );
-        split_writers.put( 'y', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_Y.html"  ) ) );
-        split_writers.put( 'z', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_Z.html"  ) ) );
-        split_writers.put( '0', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile + "_09.html"  ) ) );
+    private static void createSplitWriters( final File out_dir,
+                                            final String my_outfile,
+                                            final Map<Character, Writer> split_writers ) throws IOException {
+        split_writers.put( 'a', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_A.html" ) ) );
+        split_writers.put( 'b', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_B.html" ) ) );
+        split_writers.put( 'c', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_C.html" ) ) );
+        split_writers.put( 'd', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_D.html" ) ) );
+        split_writers.put( 'e', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_E.html" ) ) );
+        split_writers.put( 'f', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_F.html" ) ) );
+        split_writers.put( 'g', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_G.html" ) ) );
+        split_writers.put( 'h', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_H.html" ) ) );
+        split_writers.put( 'i', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_I.html" ) ) );
+        split_writers.put( 'j', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_J.html" ) ) );
+        split_writers.put( 'k', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_K.html" ) ) );
+        split_writers.put( 'l', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_L.html" ) ) );
+        split_writers.put( 'm', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_M.html" ) ) );
+        split_writers.put( 'n', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_N.html" ) ) );
+        split_writers.put( 'o', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_O.html" ) ) );
+        split_writers.put( 'p', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_P.html" ) ) );
+        split_writers.put( 'q', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_Q.html" ) ) );
+        split_writers.put( 'r', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_R.html" ) ) );
+        split_writers.put( 's', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_S.html" ) ) );
+        split_writers.put( 't', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_T.html" ) ) );
+        split_writers.put( 'u', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_U.html" ) ) );
+        split_writers.put( 'v', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_V.html" ) ) );
+        split_writers.put( 'w', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_W.html" ) ) );
+        split_writers.put( 'x', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_X.html" ) ) );
+        split_writers.put( 'y', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_Y.html" ) ) );
+        split_writers.put( 'z', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_Z.html" ) ) );
+        split_writers.put( '0', new BufferedWriter( new FileWriter( out_dir + ForesterUtil.FILE_SEPARATOR + my_outfile
+                + "_domains_0.html" ) ) );
     }
 
     private static void printOutPercentageOfMultidomainProteins( final SortedMap<Integer, Integer> all_genomes_domains_per_potein_histo,
@@ -2759,7 +2817,11 @@ public class surfacing {
             SurfacingUtil.checkForOutputFileWriteability( out );
             try {
                 final Writer proteins_file_writer = new BufferedWriter( new FileWriter( out ) );
-                SurfacingUtil.extractProteinNames( protein_lists_per_species, domain, proteins_file_writer, "\t" );
+                SurfacingUtil.extractProteinNames( protein_lists_per_species,
+                                                   domain,
+                                                   proteins_file_writer,
+                                                   "\t",
+                                                   LIMIT_SPEC_FOR_PROT_EX );
                 proteins_file_writer.close();
             }
             catch ( final IOException e ) {