Revert "JAL-2852 added framework for saving as EPS file"
[jalview.git] / forester / java / src / org / forester / archaeopteryx / MainFrameApplication.java
index e6be588..07984fc 100644 (file)
@@ -22,7 +22,7 @@
 // Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA
 //
 // Contact: phylosoft @ gmail . com
-// WWW: www.phylosoft.org/forester
+// WWW: https://sites.google.com/site/cmzmasek/home/software/forester
 
 package org.forester.archaeopteryx;
 
@@ -57,16 +57,13 @@ import javax.swing.UnsupportedLookAndFeelException;
 import javax.swing.WindowConstants;
 import javax.swing.event.ChangeEvent;
 import javax.swing.event.ChangeListener;
-import javax.swing.filechooser.FileFilter;
-import javax.swing.plaf.synth.SynthLookAndFeel;
+import javax.swing.event.InternalFrameAdapter;
+import javax.swing.event.InternalFrameEvent;
 
 import org.forester.analysis.TaxonomyDataManager;
-import org.forester.archaeopteryx.AptxUtil.GraphicsExportType;
 import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;
 import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;
 import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;
-import org.forester.archaeopteryx.tools.AncestralTaxonomyInferrer;
-import org.forester.archaeopteryx.tools.GoAnnotation;
 import org.forester.archaeopteryx.tools.InferenceManager;
 import org.forester.archaeopteryx.tools.PhyloInferenceDialog;
 import org.forester.archaeopteryx.tools.PhylogeneticInferenceOptions;
@@ -79,12 +76,11 @@ import org.forester.io.parsers.GeneralMsaParser;
 import org.forester.io.parsers.PhylogenyParser;
 import org.forester.io.parsers.nexus.NexusPhylogeniesParser;
 import org.forester.io.parsers.nhx.NHXParser;
+import org.forester.io.parsers.nhx.NHXParser.TAXONOMY_EXTRACTION;
 import org.forester.io.parsers.phyloxml.PhyloXmlDataFormatException;
 import org.forester.io.parsers.phyloxml.PhyloXmlParser;
-import org.forester.io.parsers.phyloxml.PhyloXmlUtil;
 import org.forester.io.parsers.tol.TolParser;
 import org.forester.io.parsers.util.ParserUtils;
-import org.forester.io.writers.PhylogenyWriter;
 import org.forester.io.writers.SequenceWriter;
 import org.forester.msa.Msa;
 import org.forester.msa.MsaFormatException;
@@ -93,145 +89,98 @@ import org.forester.phylogeny.PhylogenyMethods;
 import org.forester.phylogeny.PhylogenyNode;
 import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;
 import org.forester.phylogeny.data.Confidence;
+import org.forester.phylogeny.data.PhylogenyDataUtil;
+import org.forester.phylogeny.data.Sequence;
 import org.forester.phylogeny.data.Taxonomy;
 import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;
 import org.forester.phylogeny.factories.PhylogenyFactory;
 import org.forester.phylogeny.iterators.PhylogenyNodeIterator;
-import org.forester.sdi.GSDI;
-import org.forester.sdi.SDIR;
-import org.forester.sequence.Sequence;
+import org.forester.sequence.MolecularSequence;
 import org.forester.util.BasicDescriptiveStatistics;
 import org.forester.util.BasicTable;
 import org.forester.util.BasicTableParser;
 import org.forester.util.DescriptiveStatistics;
 import org.forester.util.ForesterUtil;
-import org.forester.util.WindowsUtils;
-
-class DefaultFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                || file_name.endsWith( ".nwk" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".ph" )
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".dnd" ) || file_name.endsWith( ".tree" )
-                || file_name.endsWith( ".nhx" ) || file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" )
-                || file_name.endsWith( "phylo.xml" ) || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".nexus" )
-                || file_name.endsWith( ".nx" ) || file_name.endsWith( ".nex" ) || file_name.endsWith( ".tre" )
-                || file_name.endsWith( ".zip" ) || file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" )
-                || file_name.endsWith( ".con" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "All supported files (*.xml, *.phyloxml, *phylo.xml, *.nhx, *.nh, *.newick, *.nex, *.nexus, *.phy, *.tre, *.tree, *.tol, ...)";
-    }
-}
-
-class GraphicsFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".jpg" ) || file_name.endsWith( ".jpeg" ) || file_name.endsWith( ".png" )
-                || file_name.endsWith( ".gif" ) || file_name.endsWith( ".bmp" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Image files (*.jpg, *.jpeg, *.png, *.gif, *.bmp)";
-    }
-}
-
-class MsaFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".msa" ) || file_name.endsWith( ".aln" ) || file_name.endsWith( ".fasta" )
-                || file_name.endsWith( ".fas" ) || file_name.endsWith( ".fa" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Multiple sequence alignment files (*.msa, *.aln, *.fasta, *.fa, *.fas)";
-    }
-}
-
-class SequencesFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".fasta" ) || file_name.endsWith( ".fa" ) || file_name.endsWith( ".fas" )
-                || file_name.endsWith( ".seqs" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Sequences files (*.fasta, *.fa, *.fas, *.seqs )";
-    }
-}
 
 public final class MainFrameApplication extends MainFrame {
 
-    static final String                      INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";
-    static final String                      OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";
-    private final static int                 FRAME_X_SIZE                          = 800;
-    private final static int                 FRAME_Y_SIZE                          = 800;
+    private final static int             FRAME_X_SIZE                    = 900;
+    private final static int             FRAME_Y_SIZE                    = 900;
     // Filters for the file-open dialog (classes defined in this file)
-    private final static NHFilter            nhfilter                              = new NHFilter();
-    private final static NHXFilter           nhxfilter                             = new NHXFilter();
-    private final static XMLFilter           xmlfilter                             = new XMLFilter();
-    private final static TolFilter           tolfilter                             = new TolFilter();
-    private final static NexusFilter         nexusfilter                           = new NexusFilter();
-    private final static PdfFilter           pdffilter                             = new PdfFilter();
-    private final static GraphicsFileFilter  graphicsfilefilter                    = new GraphicsFileFilter();
-    private final static MsaFileFilter       msafilter                             = new MsaFileFilter();
-    private final static SequencesFileFilter seqsfilter                            = new SequencesFileFilter();
-    private final static DefaultFilter       defaultfilter                         = new DefaultFilter();
-    private static final long                serialVersionUID                      = -799735726778865234L;
-    private final JFileChooser               _values_filechooser;
-    private final JFileChooser               _open_filechooser;
-    private final JFileChooser               _msa_filechooser;
-    private final JFileChooser               _seqs_filechooser;
-    private final JFileChooser               _open_filechooser_for_species_tree;
-    private final JFileChooser               _save_filechooser;
-    private final JFileChooser               _writetopdf_filechooser;
-    private final JFileChooser               _writetographics_filechooser;
-    // Analysis menu
-    private JMenu                            _analysis_menu;
-    private JMenuItem                        _load_species_tree_item;
-    private JMenuItem                        _gsdi_item;
-    private JMenuItem                        _root_min_dups_item;
-    private JMenuItem                        _root_min_cost_l_item;
-    private JMenuItem                        _lineage_inference;
-    private JMenuItem                        _function_analysis;
+    private static final long            serialVersionUID                = -799735726778865234L;
+    private static final boolean         PREPROCESS_TREES                = false;
+    private final JFileChooser           _values_filechooser;
+    private final JFileChooser           _sequences_filechooser;
+    private final JFileChooser           _open_filechooser;
+    private final JFileChooser           _msa_filechooser;
+    private final JFileChooser           _seqs_pi_filechooser;
+    private final JFileChooser           _open_filechooser_for_species_tree;
     // Application-only print menu items
-    private JMenuItem                        _print_item;
-    private JMenuItem                        _write_to_pdf_item;
-    private JMenuItem                        _write_to_jpg_item;
-    private JMenuItem                        _write_to_gif_item;
-    private JMenuItem                        _write_to_tif_item;
-    private JMenuItem                        _write_to_png_item;
-    private JMenuItem                        _write_to_bmp_item;
-    private Phylogeny                        _species_tree;
-    private File                             _current_dir;
-    private ButtonGroup                      _radio_group_1;
+    private JMenuItem                    _collapse_below_threshold;
+    private JMenuItem                    _collapse_below_branch_length;
+    private ButtonGroup                  _radio_group_1;
+    private ButtonGroup                  _radio_group_2;
     // Others:
-    double                                   _min_not_collapse                     = Constants.MIN_NOT_COLLAPSE_DEFAULT;
+    double                               _min_not_collapse               = AptxConstants.MIN_NOT_COLLAPSE_DEFAULT;
+    double                               _min_not_collapse_bl            = 0.001;
     // Phylogeny Inference menu
-    private JMenu                            _inference_menu;
-    private JMenuItem                        _inference_from_msa_item;
-    private JMenuItem                        _inference_from_seqs_item;
+    private JMenu                        _inference_menu;
+    private JMenuItem                    _inference_from_msa_item;
+    private JMenuItem                    _inference_from_seqs_item;
     // Phylogeny Inference
-    private PhylogeneticInferenceOptions     _phylogenetic_inference_options       = null;
-    private Msa                              _msa                                  = null;
-    private File                             _msa_file                             = null;
-    private List<Sequence>                   _seqs                                 = null;
-    private File                             _seqs_file                            = null;
-    // expression values menu:
-    JMenuItem                                _read_values_jmi;
+    private PhylogeneticInferenceOptions _phylogenetic_inference_options = null;
+    private Msa                          _msa                            = null;
+    private File                         _msa_file                       = null;
+    private List<MolecularSequence>      _seqs                           = null;
+    private File                         _seqs_file                      = null;
+    JMenuItem                            _read_values_jmi;
+    JMenuItem                            _read_seqs_jmi;
+
+    private MainFrameApplication( final Phylogeny[] phys, final Configuration config ) {
+        _configuration = config;
+        if ( _configuration == null ) {
+            throw new IllegalArgumentException( "configuration is null" );
+        }
+        setVisible( false );
+        setOptions( Options.createInstance( _configuration ) );
+        _mainpanel = new MainPanel( _configuration, this );
+        _open_filechooser = null;
+        _open_filechooser_for_species_tree = null;
+        _save_filechooser = null;
+        _writetopdf_filechooser = null;
+        _writetographics_filechooser = null;
+        _msa_filechooser = null;
+        _seqs_pi_filechooser = null;
+        _values_filechooser = null;
+        _sequences_filechooser = null;
+        _jmenubar = new JMenuBar();
+        buildFileMenu();
+        buildTypeMenu();
+        _contentpane = getContentPane();
+        _contentpane.setLayout( new BorderLayout() );
+        _contentpane.add( _mainpanel, BorderLayout.CENTER );
+        // App is this big
+        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );
+        // The window listener
+        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );
+        addInternalFrameListener( new InternalFrameAdapter() {
+
+            @Override
+            public void internalFrameClosing (final InternalFrameEvent e ) {
+                exit();
+            }
+        } );
+        //   setVisible( true );
+        if ( ( phys != null ) && ( phys.length > 0 ) ) {
+            AptxUtil.addPhylogeniesToTabs( phys, "", null, _configuration, _mainpanel );
+            validate();
+            getMainPanel().getControlPanel().showWholeAll();
+            getMainPanel().getControlPanel().showWhole();
+        }
+        //activateSaveAllIfNeeded();
+        // ...and its children
+        _contentpane.repaint();
+    }
 
     private MainFrameApplication( final Phylogeny[] phys, final Configuration config, final String title ) {
         this( phys, config, title, null );
@@ -247,30 +196,12 @@ public final class MainFrameApplication extends MainFrame {
             throw new IllegalArgumentException( "configuration is null" );
         }
         try {
-            boolean synth_exception = false;
-            if ( Constants.__SYNTH_LF ) {
-                try {
-                    final SynthLookAndFeel synth = new SynthLookAndFeel();
-                    synth.load( MainFrameApplication.class.getResourceAsStream( "/resources/synth_look_and_feel_1.xml" ),
-                                MainFrameApplication.class );
-                    UIManager.setLookAndFeel( synth );
-                }
-                catch ( final Exception ex ) {
-                    synth_exception = true;
-                    ForesterUtil.printWarningMessage( Constants.PRG_NAME,
-                                                      "could not create synth look and feel: "
-                                                              + ex.getLocalizedMessage() );
-                }
+            if ( _configuration.isUseNativeUI() ) {
+                UIManager.setLookAndFeel( UIManager.getSystemLookAndFeelClassName() );
             }
-            if ( !Constants.__SYNTH_LF || synth_exception ) {
-                if ( _configuration.isUseNativeUI() ) {
-                    UIManager.setLookAndFeel( UIManager.getSystemLookAndFeelClassName() );
-                }
-                else {
-                    UIManager.setLookAndFeel( UIManager.getCrossPlatformLookAndFeelClassName() );
-                }
+            else {
+                UIManager.setLookAndFeel( UIManager.getCrossPlatformLookAndFeelClassName() );
             }
-            //UIManager.setLookAndFeel( "com.sun.java.swing.plaf.nimbus.NimbusLookAndFeel" );
         }
         catch ( final UnsupportedLookAndFeelException e ) {
             AptxUtil.dieWithSystemError( "unsupported look and feel: " + e.toString() );
@@ -284,9 +215,6 @@ public final class MainFrameApplication extends MainFrame {
         catch ( final IllegalAccessException e ) {
             AptxUtil.dieWithSystemError( "illegal access exception: " + e.toString() );
         }
-        catch ( final Exception e ) {
-            AptxUtil.dieWithSystemError( e.toString() );
-        }
         if ( ( current_dir != null ) && current_dir.canRead() && current_dir.isDirectory() ) {
             setCurrentDir( current_dir );
         }
@@ -295,65 +223,62 @@ public final class MainFrameApplication extends MainFrame {
         setOptions( Options.createInstance( _configuration ) );
         setInferenceManager( InferenceManager.createInstance( _configuration ) );
         setPhylogeneticInferenceOptions( PhylogeneticInferenceOptions.createInstance( _configuration ) );
-        //     _textframe = null; #~~~~
-        _species_tree = null;
         // set title
-        setTitle( Constants.PRG_NAME + " " + Constants.VERSION + " (" + Constants.PRG_DATE + ")" );
+        setTitle( AptxConstants.PRG_NAME + " " + AptxConstants.VERSION + " (" + AptxConstants.PRG_DATE + ")" );
         _mainpanel = new MainPanel( _configuration, this );
         // The file dialogs
         _open_filechooser = new JFileChooser();
-        _open_filechooser.setCurrentDirectory( new File( "." ) );
-        _open_filechooser.setMultiSelectionEnabled( false );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.xmlfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhxfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.tolfilter );
+        _open_filechooser.setMultiSelectionEnabled( true );
+        _open_filechooser.addChoosableFileFilter( MainFrame.xmlfilter );
+        _open_filechooser.addChoosableFileFilter( MainFrame.nhxfilter );
+        _open_filechooser.addChoosableFileFilter( MainFrame.nhfilter );
+        _open_filechooser.addChoosableFileFilter( MainFrame.nexusfilter );
+        _open_filechooser.addChoosableFileFilter( MainFrame.tolfilter );
         _open_filechooser.addChoosableFileFilter( _open_filechooser.getAcceptAllFileFilter() );
-        _open_filechooser.setFileFilter( MainFrameApplication.defaultfilter );
+        _open_filechooser.setFileFilter( MainFrame.defaultfilter );
         _open_filechooser_for_species_tree = new JFileChooser();
-        _open_filechooser_for_species_tree.setCurrentDirectory( new File( "." ) );
         _open_filechooser_for_species_tree.setMultiSelectionEnabled( false );
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.xmlfilter );
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.tolfilter );
-        _open_filechooser_for_species_tree.setFileFilter( MainFrameApplication.xmlfilter );
-        _save_filechooser = new JFileChooser();
-        _save_filechooser.setCurrentDirectory( new File( "." ) );
-        _save_filechooser.setMultiSelectionEnabled( false );
-        _save_filechooser.setFileFilter( MainFrameApplication.xmlfilter );
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nhxfilter );
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );
-        _save_filechooser.addChoosableFileFilter( _save_filechooser.getAcceptAllFileFilter() );
-        _writetopdf_filechooser = new JFileChooser();
-        _writetopdf_filechooser.addChoosableFileFilter( MainFrameApplication.pdffilter );
-        _writetographics_filechooser = new JFileChooser();
-        _writetographics_filechooser.addChoosableFileFilter( MainFrameApplication.graphicsfilefilter );
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrame.xmlfilter );
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrame.tolfilter );
+        _open_filechooser_for_species_tree.setFileFilter( MainFrame.xmlfilter );
         // Msa:
         _msa_filechooser = new JFileChooser();
         _msa_filechooser.setName( "Read Multiple Sequence Alignment File" );
-        _msa_filechooser.setCurrentDirectory( new File( "." ) );
         _msa_filechooser.setMultiSelectionEnabled( false );
         _msa_filechooser.addChoosableFileFilter( _msa_filechooser.getAcceptAllFileFilter() );
-        _msa_filechooser.addChoosableFileFilter( MainFrameApplication.msafilter );
+        _msa_filechooser.addChoosableFileFilter( MainFrame.msafilter );
         // Seqs:
-        _seqs_filechooser = new JFileChooser();
-        _seqs_filechooser.setName( "Read Sequences File" );
-        _seqs_filechooser.setCurrentDirectory( new File( "." ) );
-        _seqs_filechooser.setMultiSelectionEnabled( false );
-        _seqs_filechooser.addChoosableFileFilter( _seqs_filechooser.getAcceptAllFileFilter() );
-        _seqs_filechooser.addChoosableFileFilter( MainFrameApplication.seqsfilter );
+        _seqs_pi_filechooser = new JFileChooser();
+        _seqs_pi_filechooser.setName( "Read Sequences File" );
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );
+        _seqs_pi_filechooser.addChoosableFileFilter( _seqs_pi_filechooser.getAcceptAllFileFilter() );
+        _seqs_pi_filechooser.addChoosableFileFilter( MainFrame.seqsfilter );
         // Expression
         _values_filechooser = new JFileChooser();
-        _values_filechooser.setCurrentDirectory( new File( "." ) );
         _values_filechooser.setMultiSelectionEnabled( false );
+        // Sequences
+        _sequences_filechooser = new JFileChooser();
+        _sequences_filechooser.setMultiSelectionEnabled( false );
+        try {
+            final String home_dir = System.getProperty( "user.home" );
+            _open_filechooser.setCurrentDirectory( new File( home_dir ) );
+            _open_filechooser_for_species_tree.setCurrentDirectory( new File( home_dir ) );
+            _msa_filechooser.setCurrentDirectory( new File( home_dir ) );
+            _seqs_pi_filechooser.setCurrentDirectory( new File( home_dir ) );
+            _values_filechooser.setCurrentDirectory( new File( home_dir ) );
+            _sequences_filechooser.setCurrentDirectory( new File( home_dir ) );
+        }
+        catch ( final Exception e ) {
+            e.printStackTrace();
+            // Do nothing. Not important.
+        }
         // build the menu bar
         _jmenubar = new JMenuBar();
         if ( !_configuration.isUseNativeUI() ) {
             _jmenubar.setBackground( getConfiguration().getGuiMenuBackgroundColor() );
         }
         buildFileMenu();
-        if ( Constants.__ALLOW_PHYLOGENETIC_INFERENCE ) {
+        if ( AptxConstants.__ALLOW_PHYLOGENETIC_INFERENCE ) {
             buildPhylogeneticInferenceMenu();
         }
         buildAnalysisMenu();
@@ -379,42 +304,40 @@ public final class MainFrameApplication extends MainFrame {
         //        } );
         // The window listener
         setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );
-        addWindowListener( new WindowAdapter() {
+        addInternalFrameListener( new InternalFrameAdapter() {
 
             @Override
-            public void windowClosing( final WindowEvent e ) {
+            public void internalFrameClosing( final InternalFrameEvent e ) {
+                if (MainFrameApplication.this.getParent() == null) {
                 if ( isUnsavedDataPresent() ) {
-                    final int r = JOptionPane.showConfirmDialog( null,
-                                                                 "Exit despite potentially unsaved changes?",
-                                                                 "Exit?",
+                    final int r = JOptionPane.showConfirmDialog( _mainpanel,
+                                                                 "Close Archaeopteryx despite potentially unsaved changes?",
+                                                                 "Close viewer?",
                                                                  JOptionPane.YES_NO_OPTION );
                     if ( r != JOptionPane.YES_OPTION ) {
                         return;
                     }
                 }
                 else {
-                    final int r = JOptionPane.showConfirmDialog( null,
-                                                                 "Exit Archaeopteryx?",
-                                                                 "Exit?",
-                                                                 JOptionPane.YES_NO_OPTION );
+                    final int r = JOptionPane
+                            .showConfirmDialog( null, "Exit Archaeopteryx?", "Exit?", JOptionPane.YES_NO_OPTION );
                     if ( r != JOptionPane.YES_OPTION ) {
                         return;
                     }
-                }
+                }}
                 exit();
-            }
-        } );
+            
+        } });
         // The component listener
         addComponentListener( new ComponentAdapter() {
 
             @Override
             public void componentResized( final ComponentEvent e ) {
                 if ( _mainpanel.getCurrentTreePanel() != null ) {
-                    _mainpanel.getCurrentTreePanel().setParametersForPainting( _mainpanel.getCurrentTreePanel()
-                                                                                       .getWidth(),
-                                                                               _mainpanel.getCurrentTreePanel()
-                                                                                       .getHeight(),
-                                                                               false );
+                    _mainpanel.getCurrentTreePanel()
+                            .calcParametersForPainting( _mainpanel.getCurrentTreePanel().getWidth(),
+                                                        _mainpanel.getCurrentTreePanel().getHeight() );
                 }
             }
         } );
@@ -433,51 +356,6 @@ public final class MainFrameApplication extends MainFrame {
         System.gc();
     }
 
-    private MainFrameApplication( final Phylogeny[] phys, final Configuration config ) {
-        _configuration = config;
-        if ( _configuration == null ) {
-            throw new IllegalArgumentException( "configuration is null" );
-        }
-        setVisible( false );
-        setOptions( Options.createInstance( _configuration ) );
-        _mainpanel = new MainPanel( _configuration, this );
-        _open_filechooser = null;
-        _open_filechooser_for_species_tree = null;
-        _save_filechooser = null;
-        _writetopdf_filechooser = null;
-        _writetographics_filechooser = null;
-        _msa_filechooser = null;
-        _seqs_filechooser = null;
-        _values_filechooser = null;
-        _jmenubar = new JMenuBar();
-        buildFileMenu();
-        buildTypeMenu();
-        _contentpane = getContentPane();
-        _contentpane.setLayout( new BorderLayout() );
-        _contentpane.add( _mainpanel, BorderLayout.CENTER );
-        // App is this big
-        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );
-        // The window listener
-        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );
-        addWindowListener( new WindowAdapter() {
-
-            @Override
-            public void windowClosing( final WindowEvent e ) {
-                exit();
-            }
-        } );
-        //   setVisible( true );
-        if ( ( phys != null ) && ( phys.length > 0 ) ) {
-            AptxUtil.addPhylogeniesToTabs( phys, "", null, _configuration, _mainpanel );
-            validate();
-            getMainPanel().getControlPanel().showWholeAll();
-            getMainPanel().getControlPanel().showWhole();
-        }
-        //activateSaveAllIfNeeded();
-        // ...and its children
-        _contentpane.repaint();
-    }
-
     private MainFrameApplication( final Phylogeny[] phys, final String config_file, final String title ) {
         // Reads the config file (false, false => not url, not applet):
         this( phys, new Configuration( config_file, false, false, true ), title );
@@ -492,57 +370,18 @@ public final class MainFrameApplication extends MainFrame {
             if ( o == _open_item ) {
                 readPhylogeniesFromFile();
             }
-            else if ( o == _save_item ) {
-                writeToFile( _mainpanel.getCurrentPhylogeny() );
-                // If subtree currently displayed, save it, instead of complete
-                // tree.
+            if ( o == _open_url_item ) {
+                readPhylogeniesFromURL();
             }
             else if ( o == _new_item ) {
                 newTree();
             }
-            else if ( o == _save_all_item ) {
-                writeAllToFile();
-            }
             else if ( o == _close_item ) {
                 closeCurrentPane();
             }
-            else if ( o == _write_to_pdf_item ) {
-                writeToPdf( _mainpanel.getCurrentPhylogeny() );
-            }
-            else if ( o == _write_to_jpg_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.JPG );
-            }
-            else if ( o == _write_to_png_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.PNG );
-            }
-            else if ( o == _write_to_gif_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.GIF );
-            }
-            else if ( o == _write_to_tif_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.TIFF );
-            }
-            else if ( o == _write_to_bmp_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.BMP );
-            }
-            else if ( o == _print_item ) {
-                print();
-            }
             else if ( o == _load_species_tree_item ) {
                 readSpeciesTreeFromFile();
             }
-            else if ( o == _lineage_inference ) {
-                if ( isSubtreeDisplayed() ) {
-                    JOptionPane.showMessageDialog( this,
-                                                   "Subtree is shown.",
-                                                   "Cannot infer ancestral taxonomies",
-                                                   JOptionPane.ERROR_MESSAGE );
-                    return;
-                }
-                executeLineageInference();
-            }
-            else if ( o == _function_analysis ) {
-                executeFunctionAnalysis();
-            }
             else if ( o == _obtain_detailed_taxonomic_information_jmi ) {
                 if ( isSubtreeDisplayed() ) {
                     return;
@@ -564,6 +403,12 @@ public final class MainFrameApplication extends MainFrame {
                 }
                 addExpressionValuesFromFile();
             }
+            else if ( o == _read_seqs_jmi ) {
+                if ( isSubtreeDisplayed() ) {
+                    return;
+                }
+                addSequencesFromFile();
+            }
             else if ( o == _move_node_names_to_tax_sn_jmi ) {
                 moveNodeNamesToTaxSn();
             }
@@ -571,68 +416,43 @@ public final class MainFrameApplication extends MainFrame {
                 moveNodeNamesToSeqNames();
             }
             else if ( o == _extract_tax_code_from_node_names_jmi ) {
-                extractTaxCodeFromNodeNames();
-            }
-            else if ( o == _gsdi_item ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                executeGSDI();
-            }
-            else if ( o == _root_min_dups_item ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                executeSDIR( false );
-            }
-            else if ( o == _root_min_cost_l_item ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                executeSDIR( true );
-            }
-            else if ( o == _graphics_export_visible_only_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _antialias_print_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_black_and_white_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_using_actual_size_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _graphics_export_using_actual_size_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_size_mi ) {
-                choosePrintSize();
-            }
-            else if ( o == _choose_pdf_width_mi ) {
-                choosePdfWidth();
+                extractTaxDataFromNodeNames();
             }
             else if ( o == _internal_number_are_confidence_for_nh_parsing_cbmi ) {
                 updateOptions( getOptions() );
             }
             else if ( o == _replace_underscores_cbmi ) {
-                if ( ( _extract_pfam_style_tax_codes_cbmi != null ) && _replace_underscores_cbmi.isSelected() ) {
-                    _extract_pfam_style_tax_codes_cbmi.setSelected( false );
+                if ( ( _extract_taxonomy_no_rbmi != null ) && !_extract_taxonomy_no_rbmi.isSelected() ) {
+                    _extract_taxonomy_no_rbmi.setSelected( true );
                 }
                 updateOptions( getOptions() );
             }
+            else if ( o == _allow_errors_in_distance_to_parent_cbmi ) {
+                updateOptions( getOptions() );
+            }
             else if ( o == _collapse_below_threshold ) {
                 if ( isSubtreeDisplayed() ) {
                     return;
                 }
                 collapseBelowThreshold();
             }
-            else if ( o == _extract_pfam_style_tax_codes_cbmi ) {
-                if ( ( _replace_underscores_cbmi != null ) && _extract_pfam_style_tax_codes_cbmi.isSelected() ) {
+           
+            else if ( o == _collapse_below_branch_length ) {
+                if ( isSubtreeDisplayed() ) {
+                    return;
+                }
+                collapseBelowBranchLengthThreshold();
+            }
+            else if ( ( o == _extract_taxonomy_pfam_strict_rbmi ) || ( o == _extract_taxonomy_pfam_relaxed_rbmi )
+                    || ( o == _extract_taxonomy_agressive_rbmi ) ) {
+                if ( _replace_underscores_cbmi != null ) {
                     _replace_underscores_cbmi.setSelected( false );
                 }
                 updateOptions( getOptions() );
             }
+            else if ( o == _extract_taxonomy_no_rbmi ) {
+                updateOptions( getOptions() );
+            }
             else if ( o == _inference_from_msa_item ) {
                 executePhyleneticInference( false );
             }
@@ -649,991 +469,237 @@ public final class MainFrameApplication extends MainFrame {
         }
     }
 
-    void buildAnalysisMenu() {
-        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );
-        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );
-        _analysis_menu.addSeparator();
-        _analysis_menu.add( _root_min_dups_item = new JMenuItem( "Root by Minimizing Duplications | Height (SDI)" ) );
-        _analysis_menu.add( _root_min_cost_l_item = new JMenuItem( "Root by Minimizing Cost L | Height (SDI)" ) );
-        _analysis_menu.addSeparator();
-        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );
-        customizeJMenuItem( _gsdi_item );
-        customizeJMenuItem( _root_min_dups_item );
-        customizeJMenuItem( _root_min_cost_l_item );
-        customizeJMenuItem( _load_species_tree_item );
-        _analysis_menu.addSeparator();
-        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );
-        customizeJMenuItem( _lineage_inference );
-        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );
-        _jmenubar.add( _analysis_menu );
+    public void end() {
+        _mainpanel.terminate();
+        _contentpane.removeAll();
+        setVisible( false );
+        dispose();
     }
 
-    void buildPhylogeneticInferenceMenu() {
-        final InferenceManager im = getInferenceManager();
-        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );
-        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );
-        customizeJMenuItem( _inference_from_msa_item );
-        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );
-        if ( im.canDoMsa() ) {
-            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );
-            customizeJMenuItem( _inference_from_seqs_item );
-            _inference_from_seqs_item
-                    .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );
-        }
-        else {
-            _inference_menu
-                    .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );
-            customizeJMenuItem( _inference_from_seqs_item );
-            _inference_from_seqs_item.setEnabled( false );
-        }
-        _jmenubar.add( _inference_menu );
+    @Override
+    public MainPanel getMainPanel() {
+        return _mainpanel;
     }
 
-    @Override
-    void buildFileMenu() {
-        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );
-        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _open_url_item = new JMenuItem( "Read Tree from URL/Webservice..." ) );
-        _file_jmenu.addSeparator();
-        final WebservicesManager webservices_manager = WebservicesManager.getInstance();
-        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager
-                .getAvailablePhylogeniesWebserviceClients().size() ];
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
-            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );
-            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );
-            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );
-        }
-        if ( getConfiguration().isEditable() ) {
-            _file_jmenu.addSeparator();
-            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );
-            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );
-        }
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );
-        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );
-        _save_all_item.setToolTipText( "Write all phylogenies to one file." );
-        _save_all_item.setEnabled( false );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );
-        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" ) || AptxUtil.canWriteFormat( "TIF" ) ) {
-            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );
-        }
-        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );
-        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );
-        if ( AptxUtil.canWriteFormat( "gif" ) ) {
-            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );
-        }
-        if ( AptxUtil.canWriteFormat( "bmp" ) ) {
-            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );
-        }
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );
-        _close_item.setToolTipText( "To close the current pane." );
-        _close_item.setEnabled( true );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );
-        // For print in color option item
-        customizeJMenuItem( _open_item );
-        _open_item
-                .setFont( new Font( _open_item.getFont().getFontName(), Font.BOLD, _open_item.getFont().getSize() + 4 ) );
-        customizeJMenuItem( _open_url_item );
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
-            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );
-        }
-        customizeJMenuItem( _save_item );
-        if ( getConfiguration().isEditable() ) {
-            customizeJMenuItem( _new_item );
-        }
-        customizeJMenuItem( _close_item );
-        customizeJMenuItem( _save_all_item );
-        customizeJMenuItem( _write_to_pdf_item );
-        customizeJMenuItem( _write_to_png_item );
-        customizeJMenuItem( _write_to_jpg_item );
-        customizeJMenuItem( _write_to_gif_item );
-        customizeJMenuItem( _write_to_tif_item );
-        customizeJMenuItem( _write_to_bmp_item );
-        customizeJMenuItem( _print_item );
-        customizeJMenuItem( _exit_item );
-        _jmenubar.add( _file_jmenu );
+    public Msa getMsa() {
+        return _msa;
     }
 
-    void buildOptionsMenu() {
-        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );
-        _options_jmenu.addChangeListener( new ChangeListener() {
-
-            @Override
-            public void stateChanged( final ChangeEvent e ) {
-                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );
-                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );
-                MainFrame
-                        .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );
-                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame
-                        .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );
-                setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );
-                setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );
-                MainFrame.updateOptionsMenuDependingOnPhylogenyType( getMainPanel(),
-                                                                     _show_scale_cbmi,
-                                                                     _show_branch_length_values_cbmi,
-                                                                     _non_lined_up_cladograms_rbmi,
-                                                                     _uniform_cladograms_rbmi,
-                                                                     _ext_node_dependent_cladogram_rbmi,
-                                                                     _label_direction_cbmi );
-                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );
-                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );
-                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );
-            }
-        } );
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );
-        _options_jmenu
-                .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );
-        _options_jmenu.add( _uniform_cladograms_rbmi = new JRadioButtonMenuItem( MainFrame.UNIFORM_CLADOGRAMS_LABEL ) );
-        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );
-        _radio_group_1 = new ButtonGroup();
-        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );
-        _radio_group_1.add( _uniform_cladograms_rbmi );
-        _radio_group_1.add( _non_lined_up_cladograms_rbmi );
-        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );
-        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );
-        _options_jmenu
-                .add( _show_branch_length_values_cbmi = new JCheckBoxMenuItem( DISPLAY_BRANCH_LENGTH_VALUES_LABEL ) );
-        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );
-        _options_jmenu.add( _show_default_node_shapes_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL ) );
-        _options_jmenu
-                .add( _taxonomy_colorize_node_shapes_cbmi = new JCheckBoxMenuItem( MainFrame.TAXONOMY_COLORIZE_NODE_SHAPES_LABEL ) );
-        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );
-        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );
-        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );
-        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );
-        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );
-        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );
-        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );
-        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );
-        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );
-        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );
-        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {
-            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( SHOW_DOMAIN_LABELS_LABEL ) );
-        }
-        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );
-        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );
-        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );
-        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),
-                                                      getConfiguration() ) );
-        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );
-        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );
-        _options_jmenu
-                .add( _print_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PDF export and Printing" ) );
-        _options_jmenu
-                .add( _graphics_export_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PNG, JPG, and GIF export" ) );
-        _options_jmenu
-                .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );
-        _options_jmenu.add( _print_size_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Input:" ), getConfiguration() ) );
-        _options_jmenu
-                .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );
-        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );
-        _options_jmenu
-                .add( _extract_pfam_style_tax_codes_cbmi = new JCheckBoxMenuItem( "Extract Taxonomy Codes from Pfam-style Labels" ) );
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );
-        _options_jmenu
-                .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );
-        _use_brackets_for_conf_in_nh_export_cbmi
-                .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );
-        _options_jmenu
-                .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );
-        customizeJMenuItem( _choose_font_mi );
-        customizeJMenuItem( _choose_minimal_confidence_mi );
-        customizeJMenuItem( _switch_colors_mi );
-        customizeJMenuItem( _print_size_mi );
-        customizeJMenuItem( _choose_pdf_width_mi );
-        customizeJMenuItem( _overview_placment_mi );
-        customizeCheckBoxMenuItem( _show_default_node_shapes_cbmi, getOptions().isShowDefaultNodeShapes() );
-        customizeCheckBoxMenuItem( _taxonomy_colorize_node_shapes_cbmi, getOptions().isTaxonomyColorizeNodeShapes() );
-        customizeJMenuItem( _cycle_node_shape_mi );
-        customizeJMenuItem( _cycle_node_fill_mi );
-        customizeJMenuItem( _choose_node_size_mi );
-        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );
-        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );
-        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );
-        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );
-        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );
-        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );
-        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );
-        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );
-        customizeRadioButtonMenuItem( _uniform_cladograms_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );
-        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );
-        customizeCheckBoxMenuItem( _show_branch_length_values_cbmi, getOptions().isShowBranchLengthValues() );
-        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );
-        customizeCheckBoxMenuItem( _label_direction_cbmi,
-                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );
-        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );
-        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );
-        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi, getOptions()
-                .isInternalNumberAreConfidenceForNhParsing() );
-        customizeCheckBoxMenuItem( _extract_pfam_style_tax_codes_cbmi, getOptions()
-                .isExtractPfamTaxonomyCodesInNhParsing() );
-        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );
-        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );
-        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );
-        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );
-        customizeCheckBoxMenuItem( _print_using_actual_size_cbmi, getOptions().isPrintUsingActualSize() );
-        customizeCheckBoxMenuItem( _graphics_export_using_actual_size_cbmi, getOptions()
-                .isGraphicsExportUsingActualSize() );
-        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );
-        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi, getOptions()
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );
-        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );
-        _jmenubar.add( _options_jmenu );
+    public File getMsaFile() {
+        return _msa_file;
     }
 
-    void buildToolsMenu() {
-        _tools_menu = createMenu( "Tools", getConfiguration() );
-        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );
-        customizeJMenuItem( _confcolor_item );
-        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );
-        customizeJMenuItem( _color_rank_jmi );
-        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );
-        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );
-        customizeJMenuItem( _taxcolor_item );
-        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete Branch Colors" ) );
-        _remove_branch_color_item.setToolTipText( "To delete branch color values from the current phylogeny" );
-        customizeJMenuItem( _remove_branch_color_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );
-        customizeJMenuItem( _annotate_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );
-        customizeJMenuItem( _midpoint_root_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );
-        customizeJMenuItem( _collapse_species_specific_subtrees );
-        _tools_menu
-                .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );
-        customizeJMenuItem( _collapse_below_threshold );
-        _collapse_below_threshold
-                .setToolTipText( "To collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );
-        _tools_menu.addSeparator();
-        _tools_menu
-                .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );
-        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );
-        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );
-        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );
-        customizeJMenuItem( _move_node_names_to_seq_names_jmi );
-        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );
-        _tools_menu
-                .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Codes from Node Names" ) );
-        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );
-        _extract_tax_code_from_node_names_jmi
-                .setToolTipText( "To extract taxonomic codes (mnemonics) from nodes names in the form of 'xyz_ECOLI'" );
-        _tools_menu.addSeparator();
-        _tools_menu
-                .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );
-        _obtain_detailed_taxonomic_information_jmi
-                .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );
-        _tools_menu
-                .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );
-        _obtain_detailed_taxonomic_information_deleting_jmi
-                .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );
-        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );
-        customizeJMenuItem( _obtain_seq_information_jmi );
-        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );
-        _tools_menu.addSeparator();
-        if ( !Constants.__RELEASE ) {
-            _tools_menu.add( _function_analysis = new JMenuItem( "Add UniProtKB Annotations" ) );
-            customizeJMenuItem( _function_analysis );
-            _function_analysis
-                    .setToolTipText( "To add UniProtKB annotations for sequences with appropriate identifiers" );
-            _tools_menu.addSeparator();
-        }
-        _tools_menu.add( _read_values_jmi = new JMenuItem( "Read Vector/Expression Values" ) );
-        customizeJMenuItem( _read_values_jmi );
-        _read_values_jmi.setToolTipText( "To add vector (e.g. gene expression) values (beta)" );
-        _jmenubar.add( _tools_menu );
+    public List<MolecularSequence> getSeqs() {
+        return _seqs;
     }
 
-    private void choosePdfWidth() {
-        final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                 "Please enter the default line width for PDF export.\n"
-                                                                         + "[current value: "
-                                                                         + getOptions().getPrintLineWidth() + "]\n",
-                                                                 "Line Width for PDF Export",
-                                                                 JOptionPane.QUESTION_MESSAGE,
-                                                                 null,
-                                                                 null,
-                                                                 getOptions().getPrintLineWidth() );
-        if ( !ForesterUtil.isEmpty( s ) ) {
-            boolean success = true;
-            float f = 0.0f;
-            final String m_str = s.trim();
-            if ( !ForesterUtil.isEmpty( m_str ) ) {
-                try {
-                    f = Float.parseFloat( m_str );
-                }
-                catch ( final Exception ex ) {
-                    success = false;
-                }
-            }
-            else {
-                success = false;
-            }
-            if ( success && ( f > 0.0 ) ) {
-                getOptions().setPrintLineWidth( f );
-            }
-        }
+    public File getSeqsFile() {
+        return _seqs_file;
     }
 
-    private void choosePrintSize() {
-        final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                 "Please enter values for width and height,\nseparated by a comma.\n"
-                                                                         + "[current values: "
-                                                                         + getOptions().getPrintSizeX() + ", "
-                                                                         + getOptions().getPrintSizeY() + "]\n"
-                                                                         + "[A4: " + Constants.A4_SIZE_X + ", "
-                                                                         + Constants.A4_SIZE_Y + "]\n" + "[US Letter: "
-                                                                         + Constants.US_LETTER_SIZE_X + ", "
-                                                                         + Constants.US_LETTER_SIZE_Y + "]",
-                                                                 "Default Size for Graphics Export",
-                                                                 JOptionPane.QUESTION_MESSAGE,
-                                                                 null,
-                                                                 null,
-                                                                 getOptions().getPrintSizeX() + ", "
-                                                                         + getOptions().getPrintSizeY() );
-        if ( !ForesterUtil.isEmpty( s ) && ( s.indexOf( ',' ) > 0 ) ) {
-            boolean success = true;
-            int x = 0;
-            int y = 0;
-            final String[] str_ary = s.split( "," );
-            if ( str_ary.length == 2 ) {
-                final String x_str = str_ary[ 0 ].trim();
-                final String y_str = str_ary[ 1 ].trim();
-                if ( !ForesterUtil.isEmpty( x_str ) && !ForesterUtil.isEmpty( y_str ) ) {
-                    try {
-                        x = Integer.parseInt( x_str );
-                        y = Integer.parseInt( y_str );
-                    }
-                    catch ( final Exception ex ) {
-                        success = false;
-                    }
+    public void readMsaFromFile() {
+        // Set an initial directory if none set yet
+        final File my_dir = getCurrentDir();
+        _msa_filechooser.setMultiSelectionEnabled( false );
+        // Open file-open dialog and set current directory
+        if ( my_dir != null ) {
+            _msa_filechooser.setCurrentDirectory( my_dir );
+        }
+        final int result = _msa_filechooser.showOpenDialog( _contentpane );
+        // All done: get the msa
+        final File file = _msa_filechooser.getSelectedFile();
+        setCurrentDir( _msa_filechooser.getCurrentDirectory() );
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            setMsaFile( null );
+            setMsa( null );
+            Msa msa = null;
+            try {
+                final InputStream is = new FileInputStream( file );
+                if ( FastaParser.isLikelyFasta( file ) ) {
+                    msa = FastaParser.parseMsa( is );
                 }
                 else {
-                    success = false;
+                    msa = GeneralMsaParser.parseMsa( is );
                 }
             }
-            else {
-                success = false;
-            }
-            if ( success && ( x > 1 ) && ( y > 1 ) ) {
-                getOptions().setPrintSizeX( x );
-                getOptions().setPrintSizeY( y );
+            catch ( final MsaFormatException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Multiple sequence alignment format error",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-        }
-    }
-
-    @Override
-    void close() {
-        if ( isUnsavedDataPresent() ) {
-            final int r = JOptionPane.showConfirmDialog( this,
-                                                         "Exit despite potentially unsaved changes?",
-                                                         "Exit?",
-                                                         JOptionPane.YES_NO_OPTION );
-            if ( r != JOptionPane.YES_OPTION ) {
+            catch ( final IOException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Failed to read multiple sequence alignment",
+                                               JOptionPane.ERROR_MESSAGE );
                 return;
             }
-        }
-        exit();
-    }
-
-    private void closeCurrentPane() {
-        if ( getMainPanel().getCurrentTreePanel() != null ) {
-            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {
-                final int r = JOptionPane.showConfirmDialog( this,
-                                                             "Close tab despite potentially unsaved changes?",
-                                                             "Close Tab?",
-                                                             JOptionPane.YES_NO_OPTION );
-                if ( r != JOptionPane.YES_OPTION ) {
-                    return;
-                }
+            catch ( final IllegalArgumentException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Unexpected error during reading of multiple sequence alignment",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-            getMainPanel().closeCurrentPane();
-            activateSaveAllIfNeeded();
-        }
-    }
-
-    private void collapse( final Phylogeny phy, final double m ) {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();
-        double min_support = Double.MAX_VALUE;
-        boolean conf_present = false;
-        while ( it.hasNext() ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.isExternal() && !n.isRoot() ) {
-                final List<Confidence> c = n.getBranchData().getConfidences();
-                if ( ( c != null ) && ( c.size() > 0 ) ) {
-                    conf_present = true;
-                    double max = 0;
-                    for( final Confidence confidence : c ) {
-                        if ( confidence.getValue() > max ) {
-                            max = confidence.getValue();
-                        }
-                    }
-                    if ( max < getMinNotCollapseConfidenceValue() ) {
-                        to_be_removed.add( n );
-                    }
-                    if ( max < min_support ) {
-                        min_support = max;
-                    }
-                }
-            }
-        }
-        if ( conf_present ) {
-            for( final PhylogenyNode node : to_be_removed ) {
-                PhylogenyMethods.removeNode( node, phy );
+            catch ( final Exception e ) {
+                setArrowCursor();
+                e.printStackTrace();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Unexpected error during reading of multiple sequence alignment",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-            if ( to_be_removed.size() > 0 ) {
-                phy.externalNodesHaveChanged();
-                phy.clearHashIdToNodeMap();
-                phy.recalculateNumberOfExternalDescendants( true );
-                getCurrentTreePanel().resetNodeIdToDistToLeafMap();
-                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();
-                getCurrentTreePanel().calculateLongestExtNodeInfo();
-                getCurrentTreePanel().setNodeInPreorderToNull();
-                getCurrentTreePanel().recalculateMaxDistanceToRoot();
-                getCurrentTreePanel().resetPreferredSize();
-                getCurrentTreePanel().setEdited( true );
-                getCurrentTreePanel().repaint();
-                repaint();
+            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Multiple sequence alignment is empty",
+                                               "Illegal Multiple Sequence Alignment",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-            if ( to_be_removed.size() > 0 ) {
-                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()
-                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "
-                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );
+            if ( msa.getNumberOfSequences() < 4 ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Multiple sequence alignment needs to contain at least 3 sequences",
+                                               "Illegal multiple sequence alignment",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-            else {
-                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "
-                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );
+            if ( msa.getLength() < 2 ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Multiple sequence alignment needs to contain at least 2 residues",
+                                               "Illegal multiple sequence alignment",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
-        }
-        else {
-            JOptionPane.showMessageDialog( this,
-                                           "No branch collapsed because no confidence values present",
-                                           "No confidence values present",
-                                           JOptionPane.INFORMATION_MESSAGE );
+            System.gc();
+            setMsaFile( _msa_filechooser.getSelectedFile() );
+            setMsa( msa );
         }
     }
 
-    private void collapseBelowThreshold() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                         "Please enter the minimum confidence value\n",
-                                                                         "Minimal Confidence Value",
-                                                                         JOptionPane.QUESTION_MESSAGE,
-                                                                         null,
-                                                                         null,
-                                                                         getMinNotCollapseConfidenceValue() );
-                if ( !ForesterUtil.isEmpty( s ) ) {
-                    boolean success = true;
-                    double m = 0.0;
-                    final String m_str = s.trim();
-                    if ( !ForesterUtil.isEmpty( m_str ) ) {
-                        try {
-                            m = Double.parseDouble( m_str );
-                        }
-                        catch ( final Exception ex ) {
-                            success = false;
-                        }
-                    }
-                    else {
-                        success = false;
-                    }
-                    if ( success && ( m >= 0.0 ) ) {
-                        setMinNotCollapseConfidenceValue( m );
-                        collapse( phy, m );
+    public void readSeqsFromFileforPI() {
+        // Set an initial directory if none set yet
+        final File my_dir = getCurrentDir();
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );
+        // Open file-open dialog and set current directory
+        if ( my_dir != null ) {
+            _seqs_pi_filechooser.setCurrentDirectory( my_dir );
+        }
+        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );
+        // All done: get the seqs
+        final File file = _seqs_pi_filechooser.getSelectedFile();
+        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            setSeqsFile( null );
+            setSeqs( null );
+            List<MolecularSequence> seqs = null;
+            try {
+                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {
+                    seqs = FastaParser.parse( new FileInputStream( file ) );
+                    for( final MolecularSequence seq : seqs ) {
+                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );
                     }
                 }
+                else {
+                    //TODO error
+                }
             }
-        }
-    }
-
-    private PhyloXmlParser createPhyloXmlParser() {
-        PhyloXmlParser xml_parser = null;
-        if ( getConfiguration().isValidatePhyloXmlAgainstSchema() ) {
-            try {
-                xml_parser = PhyloXmlParser.createPhyloXmlParserXsdValidating();
+            catch ( final MsaFormatException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Multiple sequence file format error",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
+            }
+            catch ( final IOException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Failed to read multiple sequence file",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
+            }
+            catch ( final IllegalArgumentException e ) {
+                setArrowCursor();
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "Unexpected error during reading of multiple sequence file",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
             catch ( final Exception e ) {
+                setArrowCursor();
+                e.printStackTrace();
                 JOptionPane.showMessageDialog( this,
                                                e.getLocalizedMessage(),
-                                               "failed to create validating XML parser",
-                                               JOptionPane.WARNING_MESSAGE );
+                                               "Unexpected error during reading of multiple sequence file",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Multiple sequence file is empty",
+                                               "Illegal multiple sequence file",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
+            }
+            if ( seqs.size() < 4 ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Multiple sequence file needs to contain at least 3 sequences",
+                                               "Illegal multiple sequence file",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
+            }
+            //  if ( msa.getLength() < 2 ) {
+            //       JOptionPane.showMessageDialog( this,
+            //                                      "Multiple sequence alignment needs to contain at least 2 residues",
+            //                                      "Illegal multiple sequence file",
+            //                                      JOptionPane.ERROR_MESSAGE );
+            //       return;
+            //   }
+            System.gc();
+            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );
+            setSeqs( seqs );
         }
-        if ( xml_parser == null ) {
-            xml_parser = new PhyloXmlParser();
-        }
-        return xml_parser;
     }
 
-    void executeGSDI() {
-        if ( !isOKforSDI( false, true ) ) {
-            return;
-        }
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {
+    private void addExpressionValuesFromFile() {
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {
             JOptionPane.showMessageDialog( this,
-                                           "Gene tree is not rooted.",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        final Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();
-        gene_tree.setAllNodesToNotCollapse();
-        gene_tree.recalculateNumberOfExternalDescendants( false );
-        GSDI gsdi = null;
-        try {
-            gsdi = new GSDI( gene_tree, _species_tree.copy(), false, true, true );
-        }
-        catch ( final Exception e ) {
-            JOptionPane.showMessageDialog( this, e.toString(), "Error during GSDI", JOptionPane.ERROR_MESSAGE );
-        }
-        gene_tree.setRerootable( false );
-        _mainpanel.getCurrentTreePanel().setTree( gene_tree );
-        _mainpanel.getCurrentPhylogeny().clearHashIdToNodeMap();
-        _mainpanel.getCurrentPhylogeny().recalculateNumberOfExternalDescendants( true );
-        _mainpanel.getCurrentTreePanel().resetNodeIdToDistToLeafMap();
-        _mainpanel.getCurrentTreePanel().setEdited( true );
-        getControlPanel().setShowEvents( true );
-        showWhole();
-        final int selected = _mainpanel.getTabbedPane().getSelectedIndex();
-        _mainpanel.addPhylogenyInNewTab( gsdi.getSpeciesTree(), getConfiguration(), "species tree", null );
-        showWhole();
-        _mainpanel.getTabbedPane().setSelectedIndex( selected );
-        showWhole();
-        _mainpanel.getCurrentTreePanel().setEdited( true );
-        JOptionPane.showMessageDialog( this, "Duplications: " + gsdi.getDuplicationsSum() + "\n"
-                + "Potential duplications: " + gsdi.getSpeciationOrDuplicationEventsSum() + "\n" + "Speciations: "
-                + gsdi.getSpeciationsSum(), "GSDI successfully completed", JOptionPane.INFORMATION_MESSAGE );
-    }
-
-    void executeFunctionAnalysis() {
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {
-            return;
-        }
-        final GoAnnotation a = new GoAnnotation( this,
-                                                 _mainpanel.getCurrentTreePanel(),
-                                                 _mainpanel.getCurrentPhylogeny() );
-        new Thread( a ).start();
-    }
-
-    void executeLineageInference() {
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {
+                                           "Need to load evolutionary tree first",
+                                           "Can Not Read Expression Values",
+                                           JOptionPane.WARNING_MESSAGE );
             return;
         }
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Phylogeny is not rooted.",
-                                           "Cannot infer ancestral taxonomies",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
+        final File my_dir = getCurrentDir();
+        if ( my_dir != null ) {
+            _values_filechooser.setCurrentDirectory( my_dir );
         }
-        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,
-                                                                                  _mainpanel.getCurrentTreePanel(),
-                                                                                  _mainpanel.getCurrentPhylogeny()
-                                                                                          .copy() );
-        new Thread( inferrer ).start();
-    }
-
-    private void executePhyleneticInference( final boolean from_unaligned_seqs ) {
-        final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,
-                                                                      getPhylogeneticInferenceOptions(),
-                                                                      from_unaligned_seqs );
-        dialog.activate();
-        if ( dialog.getValue() == JOptionPane.OK_OPTION ) {
-            if ( !from_unaligned_seqs ) {
-                if ( getMsa() != null ) {
-                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getMsa(),
-                                                                                    getPhylogeneticInferenceOptions()
-                                                                                            .copy(), this );
-                    new Thread( inferrer ).start();
+        final int result = _values_filechooser.showOpenDialog( _contentpane );
+        final File file = _values_filechooser.getSelectedFile();
+        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            BasicTable<String> t = null;
+            try {
+                t = BasicTableParser.parse( file, '\t' );
+                if ( t.getNumberOfColumns() < 2 ) {
+                    t = BasicTableParser.parse( file, ',' );
                 }
-                else {
-                    JOptionPane.showMessageDialog( this,
-                                                   "No multiple sequence alignment selected",
-                                                   "Phylogenetic Inference Not Launched",
-                                                   JOptionPane.WARNING_MESSAGE );
+                if ( t.getNumberOfColumns() < 2 ) {
+                    t = BasicTableParser.parse( file, ' ' );
                 }
             }
-            else {
-                if ( getSeqs() != null ) {
-                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getSeqs(),
-                                                                                    getPhylogeneticInferenceOptions()
-                                                                                            .copy(), this );
-                    new Thread( inferrer ).start();
-                }
-                else {
-                    JOptionPane.showMessageDialog( this,
-                                                   "No input sequences selected",
-                                                   "Phylogenetic Inference Not Launched",
-                                                   JOptionPane.WARNING_MESSAGE );
-                }
-            }
-        }
-    }
-
-    void executeSDIR( final boolean minimize_cost ) {
-        if ( !isOKforSDI( true, true ) ) {
-            return;
-        }
-        Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();
-        final SDIR sdiunrooted = new SDIR();
-        gene_tree.setAllNodesToNotCollapse();
-        gene_tree.recalculateNumberOfExternalDescendants( false );
-        try {
-            gene_tree = sdiunrooted.infer( gene_tree, _species_tree, minimize_cost, // minimize cost
-                                           !minimize_cost, // minimize sum of dups
-                                           true, // minimize height
-                                           true, // return tree(s)
-                                           1 )[ 0 ]; // # of trees to return
-        }
-        catch ( final Exception e ) {
-            JOptionPane.showMessageDialog( this, e.toString(), "Error during SDIR", JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        final int duplications = sdiunrooted.getMinimalDuplications();
-        gene_tree.setRerootable( false );
-        _mainpanel.getCurrentTreePanel().setTree( gene_tree );
-        getControlPanel().setShowEvents( true );
-        showWhole();
-        _mainpanel.getCurrentTreePanel().setEdited( true );
-        JOptionPane.showMessageDialog( this,
-                                       "Number of duplications: " + duplications,
-                                       "SDIR successfully completed",
-                                       JOptionPane.INFORMATION_MESSAGE );
-    }
-
-    void exit() {
-        removeAllTextFrames();
-        _mainpanel.terminate();
-        _contentpane.removeAll();
-        setVisible( false );
-        dispose();
-        System.exit( 0 );
-    }
-
-    public void end() {
-        _mainpanel.terminate();
-        _contentpane.removeAll();
-        setVisible( false );
-        dispose();
-    }
-
-    private void extractTaxCodeFromNodeNames() throws PhyloXmlDataFormatException {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final PhylogenyNodeIterator it = phy.iteratorPostorder();
-                while ( it.hasNext() ) {
-                    final PhylogenyNode n = it.next();
-                    final String name = n.getName().trim();
-                    if ( !ForesterUtil.isEmpty( name ) ) {
-                        final String code = ParserUtils
-                                .extractTaxonomyCodeFromNodeName( name, PhylogenyMethods.TAXONOMY_EXTRACTION.YES );
-                        if ( !ForesterUtil.isEmpty( code ) ) {
-                            PhylogenyMethods.setTaxonomyCode( n, code );
-                        }
-                    }
-                }
-            }
-        }
-    }
-
-    private ControlPanel getControlPanel() {
-        return getMainPanel().getControlPanel();
-    }
-
-    private File getCurrentDir() {
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {
-            if ( ForesterUtil.isWindowns() ) {
-                try {
-                    _current_dir = new File( WindowsUtils.getCurrentUserDesktopPath() );
-                }
-                catch ( final Exception e ) {
-                    _current_dir = null;
-                }
-            }
-        }
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {
-            if ( System.getProperty( "user.home" ) != null ) {
-                _current_dir = new File( System.getProperty( "user.home" ) );
-            }
-            else if ( System.getProperty( "user.dir" ) != null ) {
-                _current_dir = new File( System.getProperty( "user.dir" ) );
-            }
-        }
-        return _current_dir;
-    }
-
-    @Override
-    public MainPanel getMainPanel() {
-        return _mainpanel;
-    }
-
-    private double getMinNotCollapseConfidenceValue() {
-        return _min_not_collapse;
-    }
-
-    boolean isOKforSDI( final boolean species_tree_has_to_binary, final boolean gene_tree_has_to_binary ) {
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || _mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            return false;
-        }
-        else if ( ( _species_tree == null ) || _species_tree.isEmpty() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "No species tree loaded",
-                                           "Cannot execute SDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else if ( species_tree_has_to_binary && !_species_tree.isCompletelyBinary() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Species tree is not completely binary",
-                                           "Cannot execute SDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else if ( gene_tree_has_to_binary && !_mainpanel.getCurrentPhylogeny().isCompletelyBinary() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree is not completely binary",
-                                           "Cannot execute SDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else {
-            return true;
-        }
-    }
-
-    private boolean isUnsavedDataPresent() {
-        final List<TreePanel> tps = getMainPanel().getTreePanels();
-        for( final TreePanel tp : tps ) {
-            if ( tp.isEdited() ) {
-                return true;
-            }
-        }
-        return false;
-    }
-
-    private void moveNodeNamesToSeqNames() throws PhyloXmlDataFormatException {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                PhylogenyMethods
-                        .transferNodeNameToField( phy, PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME, false );
-            }
-        }
-    }
-
-    private void moveNodeNamesToTaxSn() throws PhyloXmlDataFormatException {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                PhylogenyMethods.transferNodeNameToField( phy,
-                                                          PhylogenyMethods.PhylogenyNodeField.TAXONOMY_SCIENTIFIC_NAME,
-                                                          false );
-            }
-        }
-    }
-
-    private void newTree() {
-        final Phylogeny[] phys = new Phylogeny[ 1 ];
-        final Phylogeny phy = new Phylogeny();
-        final PhylogenyNode node = new PhylogenyNode();
-        phy.setRoot( node );
-        phy.setRooted( true );
-        phys[ 0 ] = phy;
-        AptxUtil.addPhylogeniesToTabs( phys, "", "", getConfiguration(), getMainPanel() );
-        _mainpanel.getControlPanel().showWhole();
-        _mainpanel.getCurrentTreePanel().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        _mainpanel.getOptions().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        if ( getMainPanel().getMainFrame() == null ) {
-            // Must be "E" applet version.
-            ( ( ArchaeopteryxE ) ( ( MainPanelApplets ) getMainPanel() ).getApplet() )
-                    .setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        }
-        else {
-            getMainPanel().getMainFrame().setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        }
-        activateSaveAllIfNeeded();
-        System.gc();
-    }
-
-    private void obtainDetailedTaxonomicInformation() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final TaxonomyDataManager t = new TaxonomyDataManager( this,
-                                                                       _mainpanel.getCurrentTreePanel(),
-                                                                       phy.copy(),
-                                                                       false,
-                                                                       true );
-                new Thread( t ).start();
-            }
-        }
-    }
-
-    private void obtainDetailedTaxonomicInformationDelete() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final TaxonomyDataManager t = new TaxonomyDataManager( this,
-                                                                       _mainpanel.getCurrentTreePanel(),
-                                                                       phy.copy(),
-                                                                       true,
-                                                                       true );
-                new Thread( t ).start();
-            }
-        }
-    }
-
-    private void obtainSequenceInformation() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final SequenceDataRetriver u = new SequenceDataRetriver( this,
-                                                                         _mainpanel.getCurrentTreePanel(),
-                                                                         phy.copy() );
-                new Thread( u ).start();
-            }
-        }
-    }
-
-    private void print() {
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null )
-                || getCurrentTreePanel().getPhylogeny().isEmpty() ) {
-            return;
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getCurrentTreePanel().setParametersForPainting( getOptions().getPrintSizeX() - 80,
-                                                            getOptions().getPrintSizeY() - 140,
-                                                            true );
-            getCurrentTreePanel().resetPreferredSize();
-            getCurrentTreePanel().repaint();
-        }
-        final String job_name = Constants.PRG_NAME;
-        boolean error = false;
-        String printer_name = null;
-        try {
-            printer_name = Printer.print( getCurrentTreePanel(), job_name );
-        }
-        catch ( final Exception e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Printing Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error && ( printer_name != null ) ) {
-            String msg = "Printing data sent to printer";
-            if ( printer_name.length() > 1 ) {
-                msg += " [" + printer_name + "]";
-            }
-            JOptionPane.showMessageDialog( this, msg, "Printing...", JOptionPane.INFORMATION_MESSAGE );
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getControlPanel().showWhole();
-        }
-    }
-
-    private void printPhylogenyToPdf( final String file_name ) {
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getCurrentTreePanel().setParametersForPainting( getOptions().getPrintSizeX(),
-                                                            getOptions().getPrintSizeY(),
-                                                            true );
-            getCurrentTreePanel().resetPreferredSize();
-            getCurrentTreePanel().repaint();
-        }
-        String pdf_written_to = "";
-        boolean error = false;
-        try {
-            if ( getOptions().isPrintUsingActualSize() ) {
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name,
-                                                                  getCurrentTreePanel(),
-                                                                  getCurrentTreePanel().getWidth(),
-                                                                  getCurrentTreePanel().getHeight() );
-            }
-            else {
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name, getCurrentTreePanel(), getOptions()
-                        .getPrintSizeX(), getOptions().getPrintSizeY() );
-            }
-        }
-        catch ( final IOException e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error ) {
-            if ( !ForesterUtil.isEmpty( pdf_written_to ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Wrote PDF to: " + pdf_written_to,
-                                               "Information",
-                                               JOptionPane.INFORMATION_MESSAGE );
-            }
-            else {
-                JOptionPane.showMessageDialog( this,
-                                               "There was an unknown problem when attempting to write to PDF file: \""
-                                                       + file_name + "\"",
-                                               "Error",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getControlPanel().showWhole();
-        }
-    }
-
-    private void addExpressionValuesFromFile() {
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Need to load evolutionary tree first",
-                                           "Can Not Read Expression Values",
-                                           JOptionPane.WARNING_MESSAGE );
-            return;
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _values_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _values_filechooser.showOpenDialog( _contentpane );
-        final File file = _values_filechooser.getSelectedFile();
-        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            BasicTable<String> t = null;
-            try {
-                t = BasicTableParser.parse( file, "\t" );
-                if ( t.getNumberOfColumns() < 2 ) {
-                    t = BasicTableParser.parse( file, "," );
-                }
-                if ( t.getNumberOfColumns() < 2 ) {
-                    t = BasicTableParser.parse( file, " " );
-                }
-            }
-            catch ( final IOException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               e.getMessage(),
-                                               "Could Not Read Expression Value Table",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
+            catch ( final IOException e ) {
+                JOptionPane.showMessageDialog( this,
+                                               e.getMessage(),
+                                               "Could Not Read Expression Value Table",
+                                               JOptionPane.ERROR_MESSAGE );
+                return;
             }
             if ( t.getNumberOfColumns() < 2 ) {
                 JOptionPane.showMessageDialog( this,
@@ -1668,11 +734,10 @@ public final class MainFrameApplication extends MainFrame {
                         row = t.findRow( node_name );
                     }
                     catch ( final IllegalArgumentException e ) {
-                        JOptionPane
-                                .showMessageDialog( this,
-                                                    e.getMessage(),
-                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",
-                                                    JOptionPane.ERROR_MESSAGE );
+                        JOptionPane.showMessageDialog( this,
+                                                       e.getMessage(),
+                                                       "Error Mapping Node Identifiers to Expression Value Identifiers",
+                                                       JOptionPane.ERROR_MESSAGE );
                         return;
                     }
                     if ( row < 0 ) {
@@ -1699,193 +764,66 @@ public final class MainFrameApplication extends MainFrame {
                         l.add( d );
                     }
                     if ( !l.isEmpty() ) {
-                        if ( node.getNodeData().getProperties() != null ) {
-                            node.getNodeData().getProperties()
-                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );
-                        }
+                       
                         node.getNodeData().setVector( l );
                     }
                 }
             }
             if ( not_found > 0 ) {
-                JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found
-                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );
+                JOptionPane
+                        .showMessageDialog( this,
+                                            "Could not fine expression values for " + not_found + " external node(s)",
+                                            "Warning",
+                                            JOptionPane.WARNING_MESSAGE );
             }
             getCurrentTreePanel().setStatisticsForExpressionValues( stats );
         }
     }
 
-    private void readPhylogeniesFromFile() {
-        boolean exception = false;
-        Phylogeny[] phys = null;
-        // Set an initial directory if none set yet
+    private void addSequencesFromFile() {
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {
+            JOptionPane.showMessageDialog( this,
+                                           "Need to load evolutionary tree first",
+                                           "Can Not Read Sequences",
+                                           JOptionPane.WARNING_MESSAGE );
+            return;
+        }
         final File my_dir = getCurrentDir();
-        _open_filechooser.setMultiSelectionEnabled( true );
-        // Open file-open dialog and set current directory
         if ( my_dir != null ) {
-            _open_filechooser.setCurrentDirectory( my_dir );
+            _sequences_filechooser.setCurrentDirectory( my_dir );
         }
-        final int result = _open_filechooser.showOpenDialog( _contentpane );
-        // All done: get the file
-        final File[] files = _open_filechooser.getSelectedFiles();
-        setCurrentDir( _open_filechooser.getCurrentDirectory() );
-        boolean nhx_or_nexus = false;
-        if ( ( files != null ) && ( files.length > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            for( final File file : files ) {
-                if ( ( file != null ) && !file.isDirectory() ) {
-                    if ( _mainpanel.getCurrentTreePanel() != null ) {
-                        _mainpanel.getCurrentTreePanel().setWaitCursor();
+        final int result = _sequences_filechooser.showOpenDialog( _contentpane );
+        final File file = _sequences_filechooser.getSelectedFile();
+        List<MolecularSequence> seqs = null;
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            try {
+                final FileInputStream fis1 = new FileInputStream( file );
+                if ( FastaParser.isLikelyFasta( fis1 ) ) {
+                    final FileInputStream fis2 = new FileInputStream( file );
+                    seqs = FastaParser.parse( fis2 );
+                    try {
+                        fis2.close();
                     }
-                    else {
-                        _mainpanel.setWaitCursor();
-                    }
-                    if ( ( _open_filechooser.getFileFilter() == MainFrameApplication.nhfilter )
-                            || ( _open_filechooser.getFileFilter() == MainFrameApplication.nhxfilter ) ) {
-                        try {
-                            final NHXParser nhx = new NHXParser();
-                            setSpecialOptionsForNhxParser( nhx );
-                            phys = PhylogenyMethods.readPhylogenies( nhx, file );
-                            nhx_or_nexus = true;
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                        warnIfNotPhyloXmlValidation( getConfiguration() );
-                        try {
-                            final PhyloXmlParser xml_parser = createPhyloXmlParser();
-                            phys = PhylogenyMethods.readPhylogenies( xml_parser, file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.tolfilter ) {
-                        try {
-                            phys = PhylogenyMethods.readPhylogenies( new TolParser(), file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {
-                        try {
-                            final NexusPhylogeniesParser nex = new NexusPhylogeniesParser();
-                            setSpecialOptionsForNexParser( nex );
-                            phys = PhylogenyMethods.readPhylogenies( nex, file );
-                            nhx_or_nexus = true;
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    // "*.*":
-                    else {
-                        try {
-                            final PhylogenyParser parser = ParserUtils
-                                    .createParserDependingOnFileType( file, getConfiguration()
-                                            .isValidatePhyloXmlAgainstSchema() );
-                            if ( parser instanceof NexusPhylogeniesParser ) {
-                                final NexusPhylogeniesParser nex = ( NexusPhylogeniesParser ) parser;
-                                setSpecialOptionsForNexParser( nex );
-                                nhx_or_nexus = true;
-                            }
-                            else if ( parser instanceof NHXParser ) {
-                                final NHXParser nhx = ( NHXParser ) parser;
-                                setSpecialOptionsForNhxParser( nhx );
-                                nhx_or_nexus = true;
-                            }
-                            else if ( parser instanceof PhyloXmlParser ) {
-                                warnIfNotPhyloXmlValidation( getConfiguration() );
-                            }
-                            phys = PhylogenyMethods.readPhylogenies( parser, file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    if ( _mainpanel.getCurrentTreePanel() != null ) {
-                        _mainpanel.getCurrentTreePanel().setArrowCursor();
-                    }
-                    else {
-                        _mainpanel.setArrowCursor();
-                    }
-                    if ( !exception && ( phys != null ) && ( phys.length > 0 ) ) {
-                        boolean one_desc = false;
-                        if ( nhx_or_nexus ) {
-                            for( final Phylogeny phy : phys ) {
-                                if ( getOptions().isInternalNumberAreConfidenceForNhParsing() ) {
-                                    PhylogenyMethods.transferInternalNodeNamesToConfidence( phy );
-                                }
-                                if ( PhylogenyMethods.getMinimumDescendentsPerInternalNodes( phy ) == 1 ) {
-                                    one_desc = true;
-                                    break;
-                                }
-                            }
-                        }
-                        AptxUtil.addPhylogeniesToTabs( phys,
-                                                       file.getName(),
-                                                       file.getAbsolutePath(),
-                                                       getConfiguration(),
-                                                       getMainPanel() );
-                        _mainpanel.getControlPanel().showWhole();
-                        if ( nhx_or_nexus && one_desc ) {
-                            JOptionPane
-                                    .showMessageDialog( this,
-                                                        "One or more trees contain (a) node(s) with one descendant, "
-                                                                + ForesterUtil.LINE_SEPARATOR
-                                                                + "possibly indicating illegal parentheses within node names.",
-                                                        "Warning: Possible Error in New Hampshire Formatted Data",
-                                                        JOptionPane.WARNING_MESSAGE );
-                        }
-                    }
-                }
-            }
-        }
-        activateSaveAllIfNeeded();
-        System.gc();
-    }
-
-    public void readSeqsFromFile() {
-        // Set an initial directory if none set yet
-        final File my_dir = getCurrentDir();
-        _seqs_filechooser.setMultiSelectionEnabled( false );
-        // Open file-open dialog and set current directory
-        if ( my_dir != null ) {
-            _seqs_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _seqs_filechooser.showOpenDialog( _contentpane );
-        // All done: get the seqs
-        final File file = _seqs_filechooser.getSelectedFile();
-        setCurrentDir( _seqs_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            setSeqsFile( null );
-            setSeqs( null );
-            List<Sequence> seqs = null;
-            try {
-                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {
-                    seqs = FastaParser.parse( new FileInputStream( file ) );
-                    for( final Sequence seq : seqs ) {
-                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );
+                    catch ( final Exception e ) {
+                        // Ignore.
                     }
                 }
                 else {
-                    //TODO error
+                    JOptionPane.showMessageDialog( this,
+                                                   "Format does not appear to be Fasta",
+                                                   "Multiple sequence file format error",
+                                                   JOptionPane.ERROR_MESSAGE );
+                    return;
                 }
-            }
-            catch ( final MsaFormatException e ) {
                 try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
+                    fis1.close();
                 }
-                catch ( final Exception ex ) {
-                    // Do nothing.
+                catch ( final Exception e ) {
+                    // Ignore.
                 }
+            }
+            catch ( final MsaFormatException e ) {
+                setArrowCursor();
                 JOptionPane.showMessageDialog( this,
                                                e.getLocalizedMessage(),
                                                "Multiple sequence file format error",
@@ -1893,38 +831,15 @@ public final class MainFrameApplication extends MainFrame {
                 return;
             }
             catch ( final IOException e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                catch ( final Exception ex ) {
-                    // Do nothing.
-                }
+                setArrowCursor();
                 JOptionPane.showMessageDialog( this,
                                                e.getLocalizedMessage(),
                                                "Failed to read multiple sequence file",
                                                JOptionPane.ERROR_MESSAGE );
                 return;
             }
-            catch ( final IllegalArgumentException e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                catch ( final Exception ex ) {
-                    // Do nothing.
-                }
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
             catch ( final Exception e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                catch ( final Exception ex ) {
-                    // Do nothing.
-                }
+                setArrowCursor();
                 e.printStackTrace();
                 JOptionPane.showMessageDialog( this,
                                                e.getLocalizedMessage(),
@@ -1935,706 +850,1350 @@ public final class MainFrameApplication extends MainFrame {
             if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {
                 JOptionPane.showMessageDialog( this,
                                                "Multiple sequence file is empty",
-                                               "Illegal multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( seqs.size() < 4 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence file needs to contain at least 3 sequences",
-                                               "Illegal multiple sequence file",
+                                               "Empty multiple sequence file",
                                                JOptionPane.ERROR_MESSAGE );
+                setArrowCursor();
                 return;
             }
-            //  if ( msa.getLength() < 2 ) {
-            //       JOptionPane.showMessageDialog( this,
-            //                                      "Multiple sequence alignment needs to contain at least 2 residues",
-            //                                      "Illegal multiple sequence file",
-            //                                      JOptionPane.ERROR_MESSAGE );
-            //       return;
-            //   }
-            System.gc();
-            setSeqsFile( _seqs_filechooser.getSelectedFile() );
-            setSeqs( seqs );
-        }
-    }
-
-    public void readMsaFromFile() {
-        // Set an initial directory if none set yet
-        final File my_dir = getCurrentDir();
-        _msa_filechooser.setMultiSelectionEnabled( false );
-        // Open file-open dialog and set current directory
-        if ( my_dir != null ) {
-            _msa_filechooser.setCurrentDirectory( my_dir );
         }
-        final int result = _msa_filechooser.showOpenDialog( _contentpane );
-        // All done: get the msa
-        final File file = _msa_filechooser.getSelectedFile();
-        setCurrentDir( _msa_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            setMsaFile( null );
-            setMsa( null );
-            Msa msa = null;
-            try {
-                final InputStream is = new FileInputStream( file );
-                if ( FastaParser.isLikelyFasta( file ) ) {
-                    msa = FastaParser.parseMsa( is );
-                }
-                else {
-                    msa = GeneralMsaParser.parse( is );
-                }
+        if ( seqs != null ) {
+            for( final MolecularSequence seq : seqs ) {
+                System.out.println( seq.getIdentifier() );
             }
-            catch ( final MsaFormatException e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                catch ( final Exception ex ) {
-                    // Do nothing.
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            int total_counter = 0;
+            int attached_counter = 0;
+            for( final MolecularSequence seq : seqs ) {
+                ++total_counter;
+                final String seq_name = seq.getIdentifier();
+                if ( !ForesterUtil.isEmpty( seq_name ) ) {
+                    List<PhylogenyNode> nodes = phy.getNodesViaSequenceName( seq_name );
+                    if ( nodes.isEmpty() ) {
+                        nodes = phy.getNodesViaSequenceSymbol( seq_name );
+                    }
+                    if ( nodes.isEmpty() ) {
+                        nodes = phy.getNodesViaGeneName( seq_name );
+                    }
+                    if ( nodes.isEmpty() ) {
+                        nodes = phy.getNodes( seq_name );
+                    }
+                    if ( nodes.size() > 1 ) {
+                        JOptionPane.showMessageDialog( this,
+                                                       "Sequence name \"" + seq_name + "\" is not unique",
+                                                       "Sequence name not unique",
+                                                       JOptionPane.ERROR_MESSAGE );
+                        setArrowCursor();
+                        return;
+                    }
+                    final String[] a = seq_name.split( "\\s" );
+                    if ( nodes.isEmpty() && ( a.length > 1 ) ) {
+                        final String seq_name_split = a[ 0 ];
+                        nodes = phy.getNodesViaSequenceName( seq_name_split );
+                        if ( nodes.isEmpty() ) {
+                            nodes = phy.getNodesViaSequenceSymbol( seq_name_split );
+                        }
+                        if ( nodes.isEmpty() ) {
+                            nodes = phy.getNodes( seq_name_split );
+                        }
+                        if ( nodes.size() > 1 ) {
+                            JOptionPane.showMessageDialog( this,
+                                                           "Split sequence name \"" + seq_name_split
+                                                                   + "\" is not unique",
+                                                           "Sequence name not unique",
+                                                           JOptionPane.ERROR_MESSAGE );
+                            setArrowCursor();
+                            return;
+                        }
+                    }
+                    if ( nodes.size() == 1 ) {
+                        ++attached_counter;
+                        final PhylogenyNode n = nodes.get( 0 );
+                        if ( !n.getNodeData().isHasSequence() ) {
+                            n.getNodeData().addSequence( new org.forester.phylogeny.data.Sequence() );
+                        }
+                        n.getNodeData().getSequence().setMolecularSequence( seq.getMolecularSequenceAsString() );
+                        if ( ForesterUtil.isEmpty( n.getNodeData().getSequence().getName() ) ) {
+                            n.getNodeData().getSequence().setName( seq_name );
+                        }
+                    }
                 }
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Multiple sequence alignment format error",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
             }
-            catch ( final IOException e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                catch ( final Exception ex ) {
-                    // Do nothing.
+            if ( attached_counter > 0 ) {
+                int ext_nodes = 0;
+                int ext_nodes_with_seq = 0;
+                for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {
+                    ++ext_nodes;
+                    final PhylogenyNode n = iter.next();
+                    if ( n.getNodeData().isHasSequence()
+                            && !ForesterUtil.isEmpty( n.getNodeData().getSequence().getMolecularSequence() ) ) {
+                        ++ext_nodes_with_seq;
+                    }
                 }
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Failed to read multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IllegalArgumentException e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
+                final String s;
+                if ( ext_nodes == ext_nodes_with_seq ) {
+                    s = "All " + ext_nodes_with_seq + " external nodes now have a molecular sequence attached to them.";
                 }
-                catch ( final Exception ex ) {
-                    // Do nothing.
+                else {
+                    s = ext_nodes_with_seq + " out of " + ext_nodes
+                            + " external nodes now have a molecular sequence attached to them.";
                 }
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final Exception e ) {
-                try {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
+                if ( ( attached_counter == total_counter ) && ( ext_nodes == ext_nodes_with_seq ) ) {
+                    JOptionPane.showMessageDialog( this,
+                                                   "Attached all " + total_counter + " sequences to tree nodes.\n" + s,
+                                                   "All sequences attached",
+                                                   JOptionPane.INFORMATION_MESSAGE );
                 }
-                catch ( final Exception ex ) {
-                    // Do nothing.
+                else {
+                    JOptionPane.showMessageDialog( this,
+                                                   "Attached " + attached_counter + " sequences out of a total of "
+                                                           + total_counter + " sequences.\n" + s,
+                                                   attached_counter + " sequences attached",
+                                                   JOptionPane.WARNING_MESSAGE );
                 }
-                e.printStackTrace();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment is empty",
-                                               "Illegal Multiple Sequence Alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( msa.getNumberOfSequences() < 4 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment needs to contain at least 3 sequences",
-                                               "Illegal multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
             }
-            if ( msa.getLength() < 2 ) {
+            else {
                 JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment needs to contain at least 2 residues",
-                                               "Illegal multiple sequence alignment",
+                                               "No maching tree node for any of the " + total_counter + " sequences",
+                                               "Could not attach any sequences",
                                                JOptionPane.ERROR_MESSAGE );
-                return;
             }
-            System.gc();
-            setMsaFile( _msa_filechooser.getSelectedFile() );
-            setMsa( msa );
         }
     }
 
-    @Override
-    void readPhylogeniesFromURL() {
-        URL url = null;
-        Phylogeny[] phys = null;
-        final String message = "Please enter a complete URL, for example \"http://www.phyloxml.org/examples/apaf.xml\"";
-        final String url_string = JOptionPane.showInputDialog( this,
-                                                               message,
-                                                               "Use URL/webservice to obtain a phylogeny",
-                                                               JOptionPane.QUESTION_MESSAGE );
-        boolean nhx_or_nexus = false;
-        if ( ( url_string != null ) && ( url_string.length() > 0 ) ) {
-            try {
-                url = new URL( url_string );
-                PhylogenyParser parser = null;
-                if ( url.getHost().toLowerCase().indexOf( "tolweb" ) >= 0 ) {
-                    parser = new TolParser();
-                }
-                else {
-                    parser = ParserUtils.createParserDependingOnUrlContents( url, getConfiguration()
-                            .isValidatePhyloXmlAgainstSchema() );
-                }
-                if ( parser instanceof NexusPhylogeniesParser ) {
-                    nhx_or_nexus = true;
-                }
-                else if ( parser instanceof NHXParser ) {
-                    nhx_or_nexus = true;
-                }
-                if ( _mainpanel.getCurrentTreePanel() != null ) {
-                    _mainpanel.getCurrentTreePanel().setWaitCursor();
-                }
-                else {
-                    _mainpanel.setWaitCursor();
-                }
-                final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();
-                phys = factory.create( url.openStream(), parser );
-            }
-            catch ( final MalformedURLException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Malformed URL: " + url + "\n" + e.getLocalizedMessage(),
-                                               "Malformed URL",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-            catch ( final IOException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Could not read from " + url + "\n"
-                                                       + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),
-                                               "Failed to read URL",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-            catch ( final Exception e ) {
-                JOptionPane.showMessageDialog( this,
-                                               ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),
-                                               "Unexpected Exception",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-            finally {
-                if ( _mainpanel.getCurrentTreePanel() != null ) {
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();
-                }
-                else {
-                    _mainpanel.setArrowCursor();
-                }
-            }
-            if ( ( phys != null ) && ( phys.length > 0 ) ) {
-                if ( nhx_or_nexus && getOptions().isInternalNumberAreConfidenceForNhParsing() ) {
-                    for( final Phylogeny phy : phys ) {
-                        PhylogenyMethods.transferInternalNodeNamesToConfidence( phy );
-                    }
+    private void closeCurrentPane() {
+        if ( getMainPanel().getCurrentTreePanel() != null ) {
+            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {
+                final int r = JOptionPane.showConfirmDialog( this,
+                                                             "Close tab despite potentially unsaved changes?",
+                                                             "Close Tab?",
+                                                             JOptionPane.YES_NO_OPTION );
+                if ( r != JOptionPane.YES_OPTION ) {
+                    return;
                 }
-                AptxUtil.addPhylogeniesToTabs( phys,
-                                               new File( url.getFile() ).getName(),
-                                               new File( url.getFile() ).toString(),
-                                               getConfiguration(),
-                                               getMainPanel() );
-                _mainpanel.getControlPanel().showWhole();
             }
+            getMainPanel().closeCurrentPane();
+            activateSaveAllIfNeeded();
         }
-        activateSaveAllIfNeeded();
-        System.gc();
     }
 
-    private void readSpeciesTreeFromFile() {
-        Phylogeny t = null;
-        boolean exception = false;
-        final File my_dir = getCurrentDir();
-        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );
-        if ( my_dir != null ) {
-            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );
-        }
-        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );
-        final File file = _open_filechooser_for_species_tree.getSelectedFile();
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new PhyloXmlParser(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
+    private void collapseBelowThreshold( final Phylogeny phy ) {
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();
+        double min_support = Double.MAX_VALUE;
+        boolean conf_present = false;
+        while ( it.hasNext() ) {
+            final PhylogenyNode n = it.next();
+            if ( !n.isExternal() && !n.isRoot() ) {
+                final List<Confidence> c = n.getBranchData().getConfidences();
+                if ( ( c != null ) && ( c.size() > 0 ) ) {
+                    conf_present = true;
+                    double max = 0;
+                    for( final Confidence confidence : c ) {
+                        if ( confidence.getValue() > max ) {
+                            max = confidence.getValue();
+                        }
+                    }
+                    if ( max < getMinNotCollapseConfidenceValue() ) {
+                        to_be_removed.add( n );
+                    }
+                    if ( max < min_support ) {
+                        min_support = max;
+                    }
                 }
             }
-            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.tolfilter ) {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
-                }
+        }
+        if ( conf_present ) {
+            for( final PhylogenyNode node : to_be_removed ) {
+                PhylogenyMethods.removeNode( node, phy );
             }
-            // "*.*":
-            else {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new PhyloXmlParser(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
-                }
+            if ( to_be_removed.size() > 0 ) {
+                phy.externalNodesHaveChanged();
+                phy.clearHashIdToNodeMap();
+                phy.recalculateNumberOfExternalDescendants( true );
+                getCurrentTreePanel().resetNodeIdToDistToLeafMap();
+                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();
+                getCurrentTreePanel().calculateLongestExtNodeInfo();
+                getCurrentTreePanel().setNodeInPreorderToNull();
+                getCurrentTreePanel().recalculateMaxDistanceToRoot();
+                getCurrentTreePanel().resetPreferredSize();
+                getCurrentTreePanel().setEdited( true );
+                getCurrentTreePanel().repaint();
+                repaint();
             }
-            if ( !exception && ( t != null ) && !t.isRooted() ) {
-                exception = true;
-                t = null;
+            if ( to_be_removed.size() > 0 ) {
                 JOptionPane.showMessageDialog( this,
-                                               "Species tree is not rooted",
-                                               "Species tree not loaded",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-            if ( !exception && ( t != null ) ) {
-                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();
-                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {
-                    final PhylogenyNode node = it.next();
-                    if ( !node.getNodeData().isHasTaxonomy() ) {
-                        exception = true;
-                        t = null;
-                        JOptionPane
-                                .showMessageDialog( this,
-                                                    "Species tree contains external node(s) without taxonomy information",
-                                                    "Species tree not loaded",
-                                                    JOptionPane.ERROR_MESSAGE );
-                        break;
-                    }
-                    else {
-                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {
-                            exception = true;
-                            t = null;
-                            JOptionPane.showMessageDialog( this,
-                                                           "Taxonomy ["
-                                                                   + node.getNodeData().getTaxonomy().asSimpleText()
-                                                                   + "] is not unique in species tree",
-                                                           "Species tree not loaded",
-                                                           JOptionPane.ERROR_MESSAGE );
-                            break;
-                        }
-                        else {
-                            tax_set.add( node.getNodeData().getTaxonomy() );
-                        }
-                    }
-                }
+                                               "Collapsed " + to_be_removed.size()
+                                                       + " branches with\nconfidence values below "
+                                                       + getMinNotCollapseConfidenceValue(),
+                                               "Collapsed " + to_be_removed.size() + " branches",
+                                               JOptionPane.INFORMATION_MESSAGE );
             }
-            if ( !exception && ( t != null ) ) {
-                _species_tree = t;
+            else {
                 JOptionPane.showMessageDialog( this,
-                                               "Species tree successfully loaded",
-                                               "Species tree loaded",
+                                               "No branch collapsed,\nminimum confidence value per branch is "
+                                                       + min_support,
+                                               "No branch collapsed",
                                                JOptionPane.INFORMATION_MESSAGE );
             }
-            _contentpane.repaint();
-            System.gc();
         }
-    }
-
-    private void setCurrentDir( final File current_dir ) {
-        _current_dir = current_dir;
-    }
-
-    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {
-        _min_not_collapse = min_not_collapse;
-    }
-
-    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {
-        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
-    }
-
-    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {
-        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
-        PhylogenyMethods.TAXONOMY_EXTRACTION te = PhylogenyMethods.TAXONOMY_EXTRACTION.NO;
-        if ( getOptions().isExtractPfamTaxonomyCodesInNhParsing() ) {
-            te = PhylogenyMethods.TAXONOMY_EXTRACTION.YES;
+        else {
+            JOptionPane.showMessageDialog( this,
+                                           "No branch collapsed because no confidence values present",
+                                           "No confidence values present",
+                                           JOptionPane.INFORMATION_MESSAGE );
         }
-        nhx.setTaxonomyExtraction( te );
     }
 
-    private void writeAllToFile() {
-        if ( ( getMainPanel().getTabbedPane() == null ) || ( getMainPanel().getTabbedPane().getTabCount() < 1 ) ) {
-            return;
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _save_filechooser.setCurrentDirectory( my_dir );
-        }
-        _save_filechooser.setSelectedFile( new File( "" ) );
-        final int result = _save_filechooser.showSaveDialog( _contentpane );
-        final File file = _save_filechooser.getSelectedFile();
-        setCurrentDir( _save_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "Warning",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
-                }
-                else {
-                    try {
-                        file.delete();
+    private void collapseBelowBranchLengthThreshold() {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final String s = ( String ) JOptionPane.showInputDialog( this,
+                                                                         "Please enter the minimum branch length value\n",
+                                                                         "Minimal Branch Length Value",
+                                                                         JOptionPane.QUESTION_MESSAGE,
+                                                                         null,
+                                                                         null,
+                                                                         getMinNotCollapseBlValue() );
+                if ( !ForesterUtil.isEmpty( s ) ) {
+                    boolean success = true;
+                    double m = 0.0;
+                    final String m_str = s.trim();
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {
+                        try {
+                            m = Double.parseDouble( m_str );
+                        }
+                        catch ( final Exception ex ) {
+                            success = false;
+                        }
                     }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Error",
-                                                       JOptionPane.WARNING_MESSAGE );
+                    else {
+                        success = false;
+                    }
+                    if ( success && ( m >= 0.0 ) ) {
+                        setMinNotCollapseBlValue( m );
+                        collapseBl( phy );
                     }
                 }
             }
-            final int count = getMainPanel().getTabbedPane().getTabCount();
-            final List<Phylogeny> trees = new ArrayList<Phylogeny>();
-            for( int i = 0; i < count; ++i ) {
-                trees.add( getMainPanel().getPhylogeny( i ) );
-                getMainPanel().getTreePanels().get( i ).setEdited( false );
-            }
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            try {
-                writer.toPhyloXML( file, trees, 0, ForesterUtil.LINE_SEPARATOR );
-            }
-            catch ( final IOException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Failed to write to: " + file,
-                                               "Error",
-                                               JOptionPane.WARNING_MESSAGE );
-            }
-        }
-    }
-
-    private boolean writeAsNewHampshire( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toNewHampshire( t, false, true, getOptions().getNhConversionSupportValueStyle(), file );
-        }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
         }
-        return exception;
     }
 
-    private boolean writeAsNexus( final Phylogeny t, boolean exception, final File file ) {
+    private void collapseBelowThreshold() {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final String s = ( String ) JOptionPane.showInputDialog( this,
+                                                                         "Please enter the minimum confidence value\n",
+                                                                         "Minimal Confidence Value",
+                                                                         JOptionPane.QUESTION_MESSAGE,
+                                                                         null,
+                                                                         null,
+                                                                         getMinNotCollapseConfidenceValue() );
+                if ( !ForesterUtil.isEmpty( s ) ) {
+                    boolean success = true;
+                    double m = 0.0;
+                    final String m_str = s.trim();
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {
+                        try {
+                            m = Double.parseDouble( m_str );
+                        }
+                        catch ( final Exception ex ) {
+                            success = false;
+                        }
+                    }
+                    else {
+                        success = false;
+                    }
+                    if ( success && ( m >= 0.0 ) ) {
+                        setMinNotCollapseConfidenceValue( m );
+                        collapseBelowThreshold( phy );
+                    }
+                }
+            }
+        }
+    }
+
+    private void collapseBl( final Phylogeny phy ) {
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();
+        double min_bl = Double.MAX_VALUE;
+        boolean bl_present = false;
+        while ( it.hasNext() ) {
+            final PhylogenyNode n = it.next();
+            if ( !n.isExternal() && !n.isRoot() ) {
+                final double bl = n.getDistanceToParent();
+                if ( bl != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {
+                    bl_present = true;
+                    if ( bl < getMinNotCollapseBlValue() ) {
+                        to_be_removed.add( n );
+                    }
+                    if ( bl < min_bl ) {
+                        min_bl = bl;
+                    }
+                }
+            }
+        }
+        if ( bl_present ) {
+            for( final PhylogenyNode node : to_be_removed ) {
+                PhylogenyMethods.removeNode( node, phy );
+            }
+            if ( to_be_removed.size() > 0 ) {
+                phy.externalNodesHaveChanged();
+                phy.clearHashIdToNodeMap();
+                phy.recalculateNumberOfExternalDescendants( true );
+                getCurrentTreePanel().resetNodeIdToDistToLeafMap();
+                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();
+                getCurrentTreePanel().calculateLongestExtNodeInfo();
+                getCurrentTreePanel().setNodeInPreorderToNull();
+                getCurrentTreePanel().recalculateMaxDistanceToRoot();
+                getCurrentTreePanel().resetPreferredSize();
+                getCurrentTreePanel().setEdited( true );
+                getCurrentTreePanel().repaint();
+                repaint();
+            }
+            if ( to_be_removed.size() > 0 ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Collapsed " + to_be_removed.size()
+                                                       + " branches with\nbranch length values below "
+                                                       + getMinNotCollapseBlValue(),
+                                               "Collapsed " + to_be_removed.size() + " branches",
+                                               JOptionPane.INFORMATION_MESSAGE );
+            }
+            else {
+                JOptionPane.showMessageDialog( this,
+                                               "No branch collapsed,\nminimum branch length is " + min_bl,
+                                               "No branch collapsed",
+                                               JOptionPane.INFORMATION_MESSAGE );
+            }
+        }
+        else {
+            JOptionPane.showMessageDialog( this,
+                                           "No branch collapsed because no branch length values present",
+                                           "No branch length values present",
+                                           JOptionPane.INFORMATION_MESSAGE );
+        }
+    }
+
+    private PhyloXmlParser createPhyloXmlParser() {
+        PhyloXmlParser xml_parser = null;
+        if ( getConfiguration().isValidatePhyloXmlAgainstSchema() ) {
+            try {
+                xml_parser = PhyloXmlParser.createPhyloXmlParserXsdValidating();
+            }
+            catch ( final Exception e ) {
+                JOptionPane.showMessageDialog( this,
+                                               e.getLocalizedMessage(),
+                                               "failed to create validating XML parser",
+                                               JOptionPane.WARNING_MESSAGE );
+            }
+        }
+        if ( xml_parser == null ) {
+            xml_parser = PhyloXmlParser.createPhyloXmlParser();
+        }
+        return xml_parser;
+    }
+
+    private void executePhyleneticInference( final boolean from_unaligned_seqs ) {
+        final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,
+                                                                      getPhylogeneticInferenceOptions(),
+                                                                      from_unaligned_seqs );
+        dialog.activate();
+        if ( dialog.getValue() == JOptionPane.OK_OPTION ) {
+            if ( !from_unaligned_seqs ) {
+                if ( getMsa() != null ) {
+                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getMsa(),
+                                                                                    getPhylogeneticInferenceOptions()
+                                                                                            .copy(),
+                                                                                    this );
+                    new Thread( inferrer ).start();
+                }
+                else {
+                    JOptionPane.showMessageDialog( this,
+                                                   "No multiple sequence alignment selected",
+                                                   "Phylogenetic Inference Not Launched",
+                                                   JOptionPane.WARNING_MESSAGE );
+                }
+            }
+            else {
+                if ( getSeqs() != null ) {
+                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getSeqs(),
+                                                                                    getPhylogeneticInferenceOptions()
+                                                                                            .copy(),
+                                                                                    this );
+                    new Thread( inferrer ).start();
+                }
+                else {
+                    JOptionPane.showMessageDialog( this,
+                                                   "No input sequences selected",
+                                                   "Phylogenetic Inference Not Launched",
+                                                   JOptionPane.WARNING_MESSAGE );
+                }
+            }
+        }
+    }
+
+    private void extractTaxDataFromNodeNames() throws PhyloXmlDataFormatException {
+        final StringBuilder sb = new StringBuilder();
+        final StringBuilder sb_failed = new StringBuilder();
+        int counter = 0;
+        int counter_failed = 0;
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final PhylogenyNodeIterator it = phy.iteratorExternalForward();
+                while ( it.hasNext() ) {
+                    final PhylogenyNode n = it.next();
+                    final String name = n.getName().trim();
+                    if ( !ForesterUtil.isEmpty( name ) ) {
+                        final String nt = ParserUtils.extractTaxonomyDataFromNodeName( n,
+                                                                                       TAXONOMY_EXTRACTION.AGGRESSIVE );
+                        if ( !ForesterUtil.isEmpty( nt ) ) {
+                            if ( counter < 15 ) {
+                                sb.append( name + ": " + nt + "\n" );
+                            }
+                            else if ( counter == 15 ) {
+                                sb.append( "...\n" );
+                            }
+                            counter++;
+                        }
+                        else {
+                            if ( counter_failed < 15 ) {
+                                sb_failed.append( name + "\n" );
+                            }
+                            else if ( counter_failed == 15 ) {
+                                sb_failed.append( "...\n" );
+                            }
+                            counter_failed++;
+                        }
+                    }
+                }
+                if ( counter > 0 ) {
+                    String failed = "";
+                    String all = "all ";
+                    if ( counter_failed > 0 ) {
+                        all = "";
+                        failed = "\nCould not extract taxonomic data for " + counter_failed + " named external nodes:\n"
+                                + sb_failed;
+                    }
+                    JOptionPane.showMessageDialog( this,
+                                                   "Extracted taxonomic data from " + all + counter
+                                                           + " named external nodes:\n" + sb.toString() + failed,
+                                                   "Taxonomic Data Extraction Completed",
+                                                   counter_failed > 0 ? JOptionPane.WARNING_MESSAGE
+                                                           : JOptionPane.INFORMATION_MESSAGE );
+                }
+                else {
+                    JOptionPane.showMessageDialog( this,
+                                                   "Could not extract any taxonomic data.\nMaybe node names are empty\n"
+                                                           + "or not in the forms \"XYZ_CAEEL\", \"XYZ_6239\", or \"XYZ_Caenorhabditis_elegans\"\n"
+                                                           + "or nodes already have taxonomic data?\n",
+                                                   "No Taxonomic Data Extracted",
+                                                   JOptionPane.ERROR_MESSAGE );
+                }
+            }
+        }
+    }
+
+    private double getMinNotCollapseBlValue() {
+        return _min_not_collapse_bl;
+    }
+
+    private double getMinNotCollapseConfidenceValue() {
+        return _min_not_collapse;
+    }
+
+    private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {
+        if ( _phylogenetic_inference_options == null ) {
+            _phylogenetic_inference_options = new PhylogeneticInferenceOptions();
+        }
+        return _phylogenetic_inference_options;
+    }
+
+    private boolean isUnsavedDataPresent() {
+        final List<TreePanel> tps = getMainPanel().getTreePanels();
+        for( final TreePanel tp : tps ) {
+            if ( tp.isEdited() ) {
+                return true;
+            }
+        }
+        return false;
+    }
+
+    private void moveNodeNamesToSeqNames() throws PhyloXmlDataFormatException {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                PhylogenyMethods.transferNodeNameToField( phy,
+                                                          PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME,
+                                                          false );
+            }
+        }
+    }
+
+    private void moveNodeNamesToTaxSn() throws PhyloXmlDataFormatException {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                PhylogenyMethods.transferNodeNameToField( phy,
+                                                          PhylogenyMethods.PhylogenyNodeField.TAXONOMY_SCIENTIFIC_NAME,
+                                                          false );
+            }
+        }
+    }
+
+    private void newTree() {
+        final Phylogeny[] phys = new Phylogeny[ 1 ];
+        final Phylogeny phy = new Phylogeny();
+        final PhylogenyNode node = new PhylogenyNode();
+        phy.setRoot( node );
+        phy.setRooted( true );
+        phys[ 0 ] = phy;
+        AptxUtil.addPhylogeniesToTabs( phys, "", "", getConfiguration(), getMainPanel() );
+        _mainpanel.getControlPanel().showWhole();
+        _mainpanel.getCurrentTreePanel().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
+        _mainpanel.getOptions().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
+       
+        getMainPanel().getMainFrame().setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
+       
+        activateSaveAllIfNeeded();
+        System.gc();
+    }
+
+    private void obtainDetailedTaxonomicInformation() {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final TaxonomyDataManager t = new TaxonomyDataManager( this,
+                                                                       _mainpanel.getCurrentTreePanel(),
+                                                                       phy.copy(),
+                                                                       false,
+                                                                       true );
+                new Thread( t ).start();
+            }
+        }
+    }
+
+    private void obtainDetailedTaxonomicInformationDelete() {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final TaxonomyDataManager t = new TaxonomyDataManager( this,
+                                                                       _mainpanel.getCurrentTreePanel(),
+                                                                       phy.copy(),
+                                                                       true,
+                                                                       true );
+                new Thread( t ).start();
+            }
+        }
+    }
+
+    private void obtainSequenceInformation() {
+        if ( getCurrentTreePanel() != null ) {
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                final SequenceDataRetriver u = new SequenceDataRetriver( this,
+                                                                         _mainpanel.getCurrentTreePanel(),
+                                                                         phy.copy() );
+                new Thread( u ).start();
+            }
+        }
+    }
+
+    private void preProcessTreesUponReading( final Phylogeny[] phys ) {
+        for( final Phylogeny phy : phys ) {
+            if ( ( phy != null ) && !phy.isEmpty() ) {
+                for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {
+                    final PhylogenyNode n = it.next();
+                    if ( n.isExternal() ) {
+                        if ( n.getNodeData().isHasSequence() ) {
+                            final Sequence s = n.getNodeData().getSequence();
+                            if ( ForesterUtil.isEmpty( s.getGeneName() ) || s.getGeneName().startsWith( "LOC" ) ) {
+                                if ( ( s.getAccession() != null )
+                                        && !ForesterUtil.isEmpty( s.getAccession().getValue() ) ) {
+                                    s.setGeneName( s.getAccession().getValue() );
+                                }
+                                else if ( !ForesterUtil.isEmpty( n.getName() ) ) {
+                                    s.setGeneName( n.getName() );
+                                }
+                            }
+                        }
+                    }
+                }
+            }
+        }
+    }
+
+    private void readPhylogeniesFromFile() {
+        boolean exception = false;
+        Phylogeny[] phys = null;
+        // Set an initial directory if none set yet
+        final File my_dir = getCurrentDir();
+        // Open file-open dialog and set current directory
+        if ( my_dir != null ) {
+            _open_filechooser.setCurrentDirectory( my_dir );
+        }
+        final int result = _open_filechooser.showOpenDialog( _contentpane );
+        // All done: get the file
+        final File[] files = _open_filechooser.getSelectedFiles();
+        setCurrentDir( _open_filechooser.getCurrentDirectory() );
+        boolean nhx_or_nexus = false;
+        if ( ( files != null ) && ( files.length > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            for( final File file : files ) {
+                if ( ( file != null ) && !file.isDirectory() ) {
+                    if ( _mainpanel.getCurrentTreePanel() != null ) {
+                        _mainpanel.getCurrentTreePanel().setWaitCursor();
+                    }
+                    else {
+                        _mainpanel.setWaitCursor();
+                    }
+                    if ( ( _open_filechooser.getFileFilter() == MainFrame.nhfilter )
+                            || ( _open_filechooser.getFileFilter() == MainFrame.nhxfilter ) ) {
+                        try {
+                            final NHXParser nhx = new NHXParser();
+                            setSpecialOptionsForNhxParser( nhx );
+                            phys = PhylogenyMethods.readPhylogenies( nhx, file );
+                            nhx_or_nexus = true;
+                        }
+                        catch ( final Exception e ) {
+                            exception = true;
+                            exceptionOccuredDuringOpenFile( e );
+                        }
+                    }
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.xmlfilter ) {
+                        warnIfNotPhyloXmlValidation( getConfiguration() );
+                        try {
+                            final PhyloXmlParser xml_parser = createPhyloXmlParser();
+                            phys = PhylogenyMethods.readPhylogenies( xml_parser, file );
+                        }
+                        catch ( final Exception e ) {
+                            exception = true;
+                            exceptionOccuredDuringOpenFile( e );
+                        }
+                    }
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.tolfilter ) {
+                        try {
+                            phys = PhylogenyMethods.readPhylogenies( new TolParser(), file );
+                        }
+                        catch ( final Exception e ) {
+                            exception = true;
+                            exceptionOccuredDuringOpenFile( e );
+                        }
+                    }
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.nexusfilter ) {
+                        try {
+                            final NexusPhylogeniesParser nex = new NexusPhylogeniesParser();
+                            setSpecialOptionsForNexParser( nex );
+                            phys = PhylogenyMethods.readPhylogenies( nex, file );
+                            nhx_or_nexus = true;
+                        }
+                        catch ( final Exception e ) {
+                            exception = true;
+                            exceptionOccuredDuringOpenFile( e );
+                        }
+                    }
+                    // "*.*":
+                    else {
+                        try {
+                            final PhylogenyParser parser = ParserUtils
+                                    .createParserDependingOnFileType( file,
+                                                                      getConfiguration()
+                                                                              .isValidatePhyloXmlAgainstSchema() );
+                            if ( parser instanceof NexusPhylogeniesParser ) {
+                                final NexusPhylogeniesParser nex = ( NexusPhylogeniesParser ) parser;
+                                setSpecialOptionsForNexParser( nex );
+                                nhx_or_nexus = true;
+                            }
+                            else if ( parser instanceof NHXParser ) {
+                                final NHXParser nhx = ( NHXParser ) parser;
+                                setSpecialOptionsForNhxParser( nhx );
+                                nhx_or_nexus = true;
+                            }
+                            else if ( parser instanceof PhyloXmlParser ) {
+                                warnIfNotPhyloXmlValidation( getConfiguration() );
+                            }
+                            phys = PhylogenyMethods.readPhylogenies( parser, file );
+                        }
+                        catch ( final Exception e ) {
+                            exception = true;
+                            exceptionOccuredDuringOpenFile( e );
+                        }
+                    }
+                    if ( _mainpanel.getCurrentTreePanel() != null ) {
+                        _mainpanel.getCurrentTreePanel().setArrowCursor();
+                    }
+                    else {
+                        _mainpanel.setArrowCursor();
+                    }
+                    if ( !exception && ( phys != null ) && ( phys.length > 0 ) ) {
+                        boolean one_desc = false;
+                        if ( nhx_or_nexus ) {
+                            for( final Phylogeny phy : phys ) {
+                                if ( getOptions().isInternalNumberAreConfidenceForNhParsing() ) {
+                                    PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );
+                                }
+                                if ( PhylogenyMethods.getMinimumDescendentsPerInternalNodes( phy ) == 1 ) {
+                                    one_desc = true;
+                                    break;
+                                }
+                            }
+                        }
+                        if ( PREPROCESS_TREES ) {
+                            preProcessTreesUponReading( phys );
+                        }
+                        AptxUtil.addPhylogeniesToTabs( phys,
+                                                       file.getName(),
+                                                       file.getAbsolutePath(),
+                                                       getConfiguration(),
+                                                       getMainPanel() );
+                        _mainpanel.getControlPanel().showWhole();
+                        if ( nhx_or_nexus && one_desc ) {
+                            JOptionPane.showMessageDialog( this,
+                                                           "One or more trees contain (a) node(s) with one descendant, "
+                                                                   + ForesterUtil.LINE_SEPARATOR
+                                                                   + "possibly indicating illegal parentheses within node names.",
+                                                           "Warning: Possible Error in New Hampshire Formatted Data",
+                                                           JOptionPane.WARNING_MESSAGE );
+                        }
+                    }
+                }
+            }
+        }
+        activateSaveAllIfNeeded();
+        System.gc();
+    }
+
+    private void readSpeciesTreeFromFile() {
+        Phylogeny t = null;
+        boolean exception = false;
+        final File my_dir = getCurrentDir();
+        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );
+        if ( my_dir != null ) {
+            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );
+        }
+        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );
+        final File file = _open_filechooser_for_species_tree.getSelectedFile();
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
+            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.xmlfilter ) {
+                try {
+                    final Phylogeny[] trees = PhylogenyMethods
+                            .readPhylogenies( PhyloXmlParser.createPhyloXmlParserXsdValidating(), file );
+                    t = trees[ 0 ];
+                }
+                catch ( final Exception e ) {
+                    exception = true;
+                    exceptionOccuredDuringOpenFile( e );
+                }
+            }
+            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.tolfilter ) {
+                try {
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );
+                    t = trees[ 0 ];
+                }
+                catch ( final Exception e ) {
+                    exception = true;
+                    exceptionOccuredDuringOpenFile( e );
+                }
+            }
+            // "*.*":
+            else {
+                try {
+                    final Phylogeny[] trees = PhylogenyMethods
+                            .readPhylogenies( PhyloXmlParser.createPhyloXmlParserXsdValidating(), file );
+                    t = trees[ 0 ];
+                }
+                catch ( final Exception e ) {
+                    exception = true;
+                    exceptionOccuredDuringOpenFile( e );
+                }
+            }
+            if ( !exception && ( t != null ) && !t.isRooted() ) {
+                exception = true;
+                t = null;
+                JOptionPane.showMessageDialog( this,
+                                               "Species tree is not rooted",
+                                               "Species tree not loaded",
+                                               JOptionPane.ERROR_MESSAGE );
+            }
+            if ( !exception && ( t != null ) ) {
+                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();
+                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {
+                    final PhylogenyNode node = it.next();
+                    if ( !node.getNodeData().isHasTaxonomy() ) {
+                        exception = true;
+                        t = null;
+                        JOptionPane.showMessageDialog( this,
+                                                       "Species tree contains external node(s) without taxonomy information",
+                                                       "Species tree not loaded",
+                                                       JOptionPane.ERROR_MESSAGE );
+                        break;
+                    }
+                    else {
+                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {
+                            exception = true;
+                            t = null;
+                            JOptionPane
+                                    .showMessageDialog( this,
+                                                        "Taxonomy [" + node.getNodeData().getTaxonomy().asSimpleText()
+                                                                + "] is not unique in species tree",
+                                                        "Species tree not loaded",
+                                                        JOptionPane.ERROR_MESSAGE );
+                            break;
+                        }
+                        else {
+                            tax_set.add( node.getNodeData().getTaxonomy() );
+                        }
+                    }
+                }
+            }
+            if ( !exception && ( t != null ) ) {
+                setSpeciesTree( t );
+                JOptionPane.showMessageDialog( this,
+                                               "Species tree successfully loaded",
+                                               "Species tree loaded",
+                                               JOptionPane.INFORMATION_MESSAGE );
+            }
+            _contentpane.repaint();
+            System.gc();
+        }
+    }
+
+    private void setArrowCursor() {
         try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toNexus( file, t, getOptions().getNhConversionSupportValueStyle() );
+            _mainpanel.getCurrentTreePanel().setArrowCursor();
+        }
+        catch ( final Exception ex ) {
+            // Do nothing.
+        }
+    }
+
+    private void setMinNotCollapseBlValue( final double min_not_collapse_bl ) {
+        _min_not_collapse_bl = min_not_collapse_bl;
+    }
+
+    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {
+        _min_not_collapse = min_not_collapse;
+    }
+
+    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {
+        _phylogenetic_inference_options = phylogenetic_inference_options;
+    }
+
+    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {
+        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
+        nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );
+        nex.setParseBeastStyleExtendedTags( getOptions().isParseBeastStyleExtendedNexusTags() );
+    }
+
+    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {
+        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
+        nhx.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );
+        nhx.setAllowErrorsInDistanceToParent( getOptions().isAllowErrorsInDistanceToParent() );
+        nhx.setParseBeastStyleExtendedTags( getOptions().isParseBeastStyleExtendedNexusTags() );
+    }
+
+    void buildAnalysisMenu() {
+        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );
+        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );
+        _analysis_menu.add( _gsdir_item = new JMenuItem( "GSDIR (GSDI with re-rooting)" ) );
+        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );
+        customizeJMenuItem( _gsdi_item );
+        customizeJMenuItem( _gsdir_item );
+        customizeJMenuItem( _load_species_tree_item );
+        _analysis_menu.addSeparator();
+        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );
+        customizeJMenuItem( _lineage_inference );
+        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );
+        _jmenubar.add( _analysis_menu );
+    }
+
+    @Override
+    void buildFileMenu() {
+        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );
+        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _open_url_item = new JMenuItem( "Read Tree from URL/Webservice..." ) );
+        _file_jmenu.addSeparator();
+        final WebservicesManager webservices_manager = WebservicesManager.getInstance();
+        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager
+                .getAvailablePhylogeniesWebserviceClients().size() ];
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
+            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );
+            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );
+            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );
         }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
+        if ( getConfiguration().isEditable() ) {
+            _file_jmenu.addSeparator();
+            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );
+            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );
+        }
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );
+        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );
+        _save_all_item.setToolTipText( "Write all phylogenies to one file." );
+        _save_all_item.setEnabled( false );
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );
+        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" )
+                || AptxUtil.canWriteFormat( "TIF" ) ) {
+            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );
+        }
+        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );
+        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );
+        if ( AptxUtil.canWriteFormat( "gif" ) ) {
+            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );
+        }
+        if ( AptxUtil.canWriteFormat( "bmp" ) ) {
+            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );
+        }
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );
+        _close_item.setToolTipText( "To close the current pane." );
+        _close_item.setEnabled( true );
+        _file_jmenu.addSeparator();
+        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );
+        customizeJMenuItem( _open_item );
+        _open_item.setFont( new Font( _open_item.getFont().getFontName(),
+                                      Font.BOLD,
+                                      _open_item.getFont().getSize() + 4 ) );
+        customizeJMenuItem( _open_url_item );
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
+            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );
+        }
+        customizeJMenuItem( _save_item );
+        if ( getConfiguration().isEditable() ) {
+            customizeJMenuItem( _new_item );
         }
-        return exception;
+        customizeJMenuItem( _close_item );
+        customizeJMenuItem( _save_all_item );
+        customizeJMenuItem( _write_to_pdf_item );
+        customizeJMenuItem( _write_to_png_item );
+        customizeJMenuItem( _write_to_jpg_item );
+        customizeJMenuItem( _write_to_gif_item );
+        customizeJMenuItem( _write_to_tif_item );
+        customizeJMenuItem( _write_to_bmp_item );
+        customizeJMenuItem( _print_item );
+        customizeJMenuItem( _exit_item );
+        _jmenubar.add( _file_jmenu );
     }
 
-    private boolean writeAsNHX( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toNewHampshireX( t, file );
+    void buildOptionsMenu() {
+        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );
+        _options_jmenu.addChangeListener( new ChangeListener() {
+
+            @Override
+            public void stateChanged( final ChangeEvent e ) {
+                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );
+                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );
+                MainFrame.setTextMinSupportMenuItem( _choose_minimal_confidence_mi,
+                                                     getOptions(),
+                                                     getCurrentTreePanel() );
+                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi,
+                                                         MainFrame.createCurrentFontDesc( getMainPanel()
+                                                                 .getTreeFontSet() ) );
+                //  MainFrame.setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );
+                MainFrame.setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );
+                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );
+                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );
+                MainFrame.setCycleDataReturnMenuItem( _cycle_data_return, getOptions() );
+                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );
+                try {
+                    getMainPanel().getControlPanel().setVisibilityOfDomainStrucureCB();
+                    getMainPanel().getControlPanel().setVisibilityOfX();
+                }
+                catch ( final Exception ignore ) {
+                    // do nothing, not important.
+                }
+            }
+        } );
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );
+        _options_jmenu
+                .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );
+        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );
+        _radio_group_1 = new ButtonGroup();
+        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );
+         _radio_group_1.add( _non_lined_up_cladograms_rbmi );
+        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );
+        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );
+        _options_jmenu
+                .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );
+        _options_jmenu
+                .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );
+        _options_jmenu
+                .add( _show_default_node_shapes_for_marked_cbmi = new JCheckBoxMenuItem( MainFrame.DISPLAY_NODE_BOXES_LABEL_MARKED ) );
+      
+        _options_jmenu
+        .add( _collapsed_with_average_height_cbmi = new JCheckBoxMenuItem( "Proportional Height of Collapsed Subtrees" ) );
+
+        
+        _options_jmenu
+        .add( _show_abbreviated_labels_for_collapsed_nodes_cbmi = new JCheckBoxMenuItem( "Add Abbreviated Labels to Collapsed Subtrees" ) );
+
+     
+        
+        _options_jmenu
+                .add( _line_up_renderable_data_cbmi = new JCheckBoxMenuItem( MainFrame.LINE_UP_RENDERABLE_DATA ) );
+        
+       
+        
+        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {
+            _options_jmenu
+                    .add( _right_line_up_domains_cbmi = new JCheckBoxMenuItem( MainFrame.RIGHT_LINE_UP_DOMAINS ) );
+            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( MainFrame.SHOW_DOMAIN_LABELS_LABEL ) );
         }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
+        _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );
+        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );
+        _options_jmenu.add( _color_by_taxonomic_group_cbmi = new JCheckBoxMenuItem( COLOR_BY_TAXONOMIC_GROUP ) );
+        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );
+        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );
+        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );
+        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );
+        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );
+        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );
+        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );
+        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );
+        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );
+        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );
+        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );
+        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );
+        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );
+        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );
+        _options_jmenu.addSeparator();
+        _options_jmenu.add( _cycle_data_return = new JMenuItem( "Cycle Data Return" ) );
+        _options_jmenu.addSeparator();
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );
+        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );
+        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );
+        _options_jmenu.add( _search_with_regex_cbmi = new JCheckBoxMenuItem( MainFrame.SEARCH_REGEX_LABEL ) );
+        _search_with_regex_cbmi.setToolTipText( MainFrame.SEARCH_WITH_REGEX_TIP );
+        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );
+        _options_jmenu
+                .add( _color_all_found_nodes_when_coloring_subtree_cbmi = new JCheckBoxMenuItem( "Colorize All Found Nodes When Colorizing Subtree(s)" ) );
+        _options_jmenu.addSeparator();
+        _options_jmenu
+                .add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ), getConfiguration() ) );
+        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );
+        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );
+        _options_jmenu
+                .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );
+        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );
+        _options_jmenu.addSeparator();
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Read:" ), getConfiguration() ) );
+        _options_jmenu
+                .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );
+        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );
+        _options_jmenu
+                .add( _parse_beast_style_extended_nexus_tags_cbmi = new JCheckBoxMenuItem( "Parse BEAST-style extended Newick/Nexus tags" ) );
+        _parse_beast_style_extended_nexus_tags_cbmi
+                .setToolTipText( "to parse elements in the form of \"[&!color=#800080]\" in Newick/Nexus formatted trees" );
+        _options_jmenu
+                .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );
+        _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );
+        _options_jmenu
+                .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );
+        _options_jmenu
+                .add( _extract_taxonomy_pfam_relaxed_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style like Node Names" ) );
+        _options_jmenu
+                .add( _extract_taxonomy_agressive_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids/Scientific Names from Node Names" ) );
+        _extract_taxonomy_pfam_strict_rbmi
+                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"BCL2_MOUSE/123-304\" or \"BCL2_10090/123-304\"" );
+        _extract_taxonomy_pfam_relaxed_rbmi
+                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"bax_MOUSE\" or \"bax_10090\"" );
+        _extract_taxonomy_agressive_rbmi
+                .setToolTipText( "To extract taxonomy codes/ids or scientific names from node names in the form of e.g. \"MOUSE\" or \"10090\" or \"xyz_Nematostella_vectensis\"" );
+        _radio_group_2 = new ButtonGroup();
+        _radio_group_2.add( _extract_taxonomy_no_rbmi );
+        _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );
+        _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );
+        _radio_group_2.add( _extract_taxonomy_agressive_rbmi );
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Save:" ), getConfiguration() ) );
+        _options_jmenu
+                .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );
+        _use_brackets_for_conf_in_nh_export_cbmi
+                .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );
+        _options_jmenu
+                .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );
+        customizeJMenuItem( _choose_font_mi );
+        customizeJMenuItem( _choose_minimal_confidence_mi );
+        customizeJMenuItem( _switch_colors_mi );
+        customizeJMenuItem( _choose_pdf_width_mi );
+        customizeJMenuItem( _overview_placment_mi );
+        customizeCheckBoxMenuItem( _show_default_node_shapes_external_cbmi,
+                                   getOptions().isShowDefaultNodeShapesExternal() );
+        customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi,
+                                   getOptions().isShowDefaultNodeShapesInternal() );
+        customizeCheckBoxMenuItem( _show_default_node_shapes_for_marked_cbmi,
+                                   getOptions().isShowDefaultNodeShapesForMarkedNodes() );
+        customizeJMenuItem( _cycle_node_shape_mi );
+        customizeJMenuItem( _cycle_node_fill_mi );
+        customizeJMenuItem( _choose_node_size_mi );
+        customizeJMenuItem( _cycle_data_return );
+        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch,
+                                   getOptions().isColorLabelsSameAsParentBranch() );
+        customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );
+        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );
+        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );
+        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );
+        customizeCheckBoxMenuItem( _show_annotation_ref_source, getOptions().isShowAnnotationRefSource() );
+        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );
+        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );
+        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );
+        customizeCheckBoxMenuItem( _collapsed_with_average_height_cbmi, getOptions().isCollapsedWithAverageHeigh() );
+        customizeCheckBoxMenuItem( _show_abbreviated_labels_for_collapsed_nodes_cbmi, getOptions().isShowAbbreviatedLabelsForCollapsedNodes() );
+        
+        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );
+        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.LINED_UP );
+        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );
+        customizeCheckBoxMenuItem( _label_direction_cbmi,
+                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );
+        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );
+        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );
+        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi,
+                                   getOptions().isInternalNumberAreConfidenceForNhParsing() );
+        customizeRadioButtonMenuItem( _extract_taxonomy_no_rbmi,
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.NO );
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_strict_rbmi,
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_relaxed_rbmi,
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );
+        customizeRadioButtonMenuItem( _extract_taxonomy_agressive_rbmi,
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.AGGRESSIVE );
+        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );
+        customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi,
+                                   getOptions().isReplaceUnderscoresInNhParsing() );
+        customizeCheckBoxMenuItem( _search_with_regex_cbmi, getOptions().isSearchWithRegex() );
+        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );
+        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );
+        customizeCheckBoxMenuItem( _color_all_found_nodes_when_coloring_subtree_cbmi,
+                                   getOptions().isColorAllFoundNodesWhenColoringSubtree() );
+        customizeCheckBoxMenuItem( _parse_beast_style_extended_nexus_tags_cbmi,
+                                   getOptions().isParseBeastStyleExtendedNexusTags() );
+        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );
+        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );
+        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi,
+                                   getOptions()
+                                           .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );
+        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi,
+                                   getOptions()
+                                           .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );
+        customizeCheckBoxMenuItem( _line_up_renderable_data_cbmi, getOptions().isLineUpRendarableNodeData() );
+        customizeCheckBoxMenuItem( _right_line_up_domains_cbmi, getOptions().isRightLineUpDomains() );
+        _jmenubar.add( _options_jmenu );
+    }
+
+    void buildPhylogeneticInferenceMenu() {
+        final InferenceManager im = getInferenceManager();
+        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );
+        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );
+        customizeJMenuItem( _inference_from_msa_item );
+        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );
+        if ( im.canDoMsa() ) {
+            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );
+            customizeJMenuItem( _inference_from_seqs_item );
+            _inference_from_seqs_item
+                    .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );
+        }
+        else {
+            _inference_menu
+                    .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );
+            customizeJMenuItem( _inference_from_seqs_item );
+            _inference_from_seqs_item.setEnabled( false );
         }
-        return exception;
+        _jmenubar.add( _inference_menu );
+    }
+
+    void buildToolsMenu() {
+        _tools_menu = createMenu( "Tools", getConfiguration() );
+        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );
+        customizeJMenuItem( _confcolor_item );
+        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );
+        customizeJMenuItem( _color_rank_jmi );
+        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );
+        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );
+        customizeJMenuItem( _taxcolor_item );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _remove_visual_styles_item = new JMenuItem( "Delete All Visual Styles From Nodes" ) );
+        _remove_visual_styles_item
+                .setToolTipText( "To remove all node visual styles (fonts, colors) from the current phylogeny" );
+        customizeJMenuItem( _remove_visual_styles_item );
+        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete All Colors From Branches" ) );
+        _remove_branch_color_item.setToolTipText( "To remove all branch color values from the current phylogeny" );
+        customizeJMenuItem( _remove_branch_color_item );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );
+        customizeJMenuItem( _annotate_item );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );
+        customizeJMenuItem( _midpoint_root_item );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _delete_selected_nodes_item = new JMenuItem( "Delete Selected Nodes" ) );
+        _delete_selected_nodes_item.setToolTipText( "To delete all selected external nodes" );
+        customizeJMenuItem( _delete_selected_nodes_item );
+        _tools_menu.add( _delete_not_selected_nodes_item = new JMenuItem( "Retain Selected Nodes" ) );
+        _delete_not_selected_nodes_item.setToolTipText( "To delete all not selected external nodes" );
+        customizeJMenuItem( _delete_not_selected_nodes_item );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Single Taxonomy-Subtrees" ) );
+        customizeJMenuItem( _collapse_species_specific_subtrees );
+        _collapse_species_specific_subtrees.setToolTipText( "To (reversibly) collapse subtrees associated with only one taxonomy (such as species specific subtrees)" );
+        _tools_menu
+                .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );
+        customizeJMenuItem( _collapse_below_threshold );
+        _collapse_below_threshold
+                .setToolTipText( "To (permanently) collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );
+        //
+        _tools_menu
+                .add( _collapse_below_branch_length = new JMenuItem( "Collapse Branches with Branch Lengths Below Threshold into Multifurcations" ) );
+        customizeJMenuItem( _collapse_below_branch_length );
+        _collapse_below_branch_length
+                .setToolTipText( "To (permanently) collapse branches with branches with branch lengths below a threshold into multifurcations" );
+        //
+        _tools_menu.addSeparator();
+        _tools_menu
+                .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );
+        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );
+        _extract_tax_code_from_node_names_jmi
+                .setToolTipText( "To extract SwissProt/Uniprot taxonomic codes (mnemonics) from nodes names in the form of 'xyz_CAEEL', Uniprot/NCBI identifiers form of 'xyz_6239', or scientific names form of 'xyz_Caenorhabditis_elegans'" );
+        _tools_menu
+                .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );
+        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );
+        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );
+        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );
+        customizeJMenuItem( _move_node_names_to_seq_names_jmi );
+        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );
+        customizeJMenuItem( _obtain_seq_information_jmi );
+        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );
+        _tools_menu
+                .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );
+        _obtain_detailed_taxonomic_information_jmi
+                .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );
+        _tools_menu
+                .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );
+        _obtain_detailed_taxonomic_information_deleting_jmi
+                .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );
+        _tools_menu.addSeparator();
+        _tools_menu.add( _read_values_jmi = new JMenuItem( "Attach Vector/Expression Values" ) );
+        customizeJMenuItem( _read_values_jmi );
+        _read_values_jmi.setToolTipText( "To attach vector (e.g. gene expression) values to tree nodes (beta)" );
+        _jmenubar.add( _tools_menu );
+        _tools_menu.add( _read_seqs_jmi = new JMenuItem( "Attach Molecular Sequences" ) );
+        customizeJMenuItem( _read_seqs_jmi );
+        _read_seqs_jmi
+                .setToolTipText( "To attach molecular sequences to tree nodes (from Fasta-formatted file) (beta)" );
+        _jmenubar.add( _tools_menu );
     }
 
-    private boolean writeAsPhyloXml( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toPhyloXML( file, t, 0 );
-        }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
+    @Override
+    void close() {
+        if ( isUnsavedDataPresent() ) {
+            final int r = JOptionPane.showConfirmDialog( this,
+                                                         "Exit despite potentially unsaved changes?",
+                                                         "Exit?",
+                                                         JOptionPane.YES_NO_OPTION );
+            if ( r != JOptionPane.YES_OPTION ) {
+                return;
+            }
         }
-        return exception;
+        exit();
     }
 
-    void writePhylogenyToGraphicsFile( final String file_name, final GraphicsExportType type ) {
-        _mainpanel.getCurrentTreePanel().setParametersForPainting( _mainpanel.getCurrentTreePanel().getWidth(),
-                                                                   _mainpanel.getCurrentTreePanel().getHeight(),
-                                                                   true );
-        String file_written_to = "";
-        boolean error = false;
-        try {
-            file_written_to = AptxUtil.writePhylogenyToGraphicsFile( file_name,
-                                                                     _mainpanel.getCurrentTreePanel().getWidth(),
-                                                                     _mainpanel.getCurrentTreePanel().getHeight(),
-                                                                     _mainpanel.getCurrentTreePanel(),
-                                                                     _mainpanel.getControlPanel(),
-                                                                     type,
-                                                                     getOptions() );
-        }
-        catch ( final IOException e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error ) {
-            if ( ( file_written_to != null ) && ( file_written_to.length() > 0 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Wrote image to: " + file_written_to,
-                                               "Graphics Export",
-                                               JOptionPane.INFORMATION_MESSAGE );
-            }
-            else {
-                JOptionPane.showMessageDialog( this,
-                                               "There was an unknown problem when attempting to write to an image file: \""
-                                                       + file_name + "\"",
-                                               "Error",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-        }
-        _contentpane.repaint();
+    void exit() {
+        removeAllTextFrames();
+        _mainpanel.terminate();
+        _contentpane.removeAll();
+        setVisible( false );
+        dispose();
+        // System.exit( 0 ); //TODO reconfirm that this is OK, then remove.
     }
 
-    private void writeToFile( final Phylogeny t ) {
-        if ( t == null ) {
-            return;
-        }
-        String initial_filename = null;
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
+    void readPhylogeniesFromURL() {
+        URL url = null;
+        Phylogeny[] phys = null;
+        final String message = "Please enter a complete URL, for example \"http://purl.org/phylo/treebase/phylows/study/TB2:S15480?format=nexus\"";
+        final String url_string = JOptionPane
+                .showInputDialog( this,
+                                  message,
+                                  "Use URL/webservice to obtain a phylogeny",
+                                  JOptionPane.QUESTION_MESSAGE );
+        boolean nhx_or_nexus = false;
+        if ( ( url_string != null ) && ( url_string.length() > 0 ) ) {
             try {
-                initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().getCanonicalPath();
-            }
-            catch ( final IOException e ) {
-                initial_filename = null;
-            }
-        }
-        if ( !ForesterUtil.isEmpty( initial_filename ) ) {
-            _save_filechooser.setSelectedFile( new File( initial_filename ) );
-        }
-        else {
-            _save_filechooser.setSelectedFile( new File( "" ) );
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _save_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _save_filechooser.showSaveDialog( _contentpane );
-        final File file = _save_filechooser.getSelectedFile();
-        setCurrentDir( _save_filechooser.getCurrentDirectory() );
-        boolean exception = false;
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists.\nOverwrite?",
-                                                             "Overwrite?",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.QUESTION_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
+                url = new URL( url_string );
+                PhylogenyParser parser = null;
+                if ( url.getHost().toLowerCase().indexOf( "tolweb" ) >= 0 ) {
+                    parser = new TolParser();
                 }
                 else {
-                    final File to = new File( file.getAbsoluteFile().toString() + Constants.BACKUP_FILE_SUFFIX );
-                    try {
-                        ForesterUtil.copyFile( file, to );
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to create backup copy " + to,
-                                                       "Failed to Create Backup Copy",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
-                    try {
-                        file.delete();
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Failed to Delete",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
+                    parser = ParserUtils
+                            .createParserDependingOnUrlContents( url,
+                                                                 getConfiguration().isValidatePhyloXmlAgainstSchema() );
                 }
-            }
-            if ( _save_filechooser.getFileFilter() == MainFrameApplication.nhfilter ) {
-                exception = writeAsNewHampshire( t, exception, file );
-            }
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.nhxfilter ) {
-                exception = writeAsNHX( t, exception, file );
-            }
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                exception = writeAsPhyloXml( t, exception, file );
-            }
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {
-                exception = writeAsNexus( t, exception, file );
-            }
-            // "*.*":
-            else {
-                final String file_name = file.getName().trim().toLowerCase();
-                if ( file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                        || file_name.endsWith( ".tree" ) ) {
-                    exception = writeAsNewHampshire( t, exception, file );
+                if ( parser instanceof NexusPhylogeniesParser ) {
+                    nhx_or_nexus = true;
                 }
-                else if ( file_name.endsWith( ".nhx" ) ) {
-                    exception = writeAsNHX( t, exception, file );
+                else if ( parser instanceof NHXParser ) {
+                    nhx_or_nexus = true;
                 }
-                else if ( file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) ) {
-                    exception = writeAsNexus( t, exception, file );
+                if ( _mainpanel.getCurrentTreePanel() != null ) {
+                    _mainpanel.getCurrentTreePanel().setWaitCursor();
                 }
-                // XML is default:
                 else {
-                    exception = writeAsPhyloXml( t, exception, file );
+                    _mainpanel.setWaitCursor();
                 }
+                final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();
+                phys = factory.create( url.openStream(), parser );
             }
-            if ( !exception ) {
-                getMainPanel().setTitleOfSelectedTab( file.getName() );
-                getMainPanel().getCurrentTreePanel().setTreeFile( file );
-                getMainPanel().getCurrentTreePanel().setEdited( false );
+            catch ( final MalformedURLException e ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Malformed URL: " + url + "\n" + e.getLocalizedMessage(),
+                                               "Malformed URL",
+                                               JOptionPane.ERROR_MESSAGE );
             }
-        }
-    }
-
-    private void writeToGraphicsFile( final Phylogeny t, final GraphicsExportType type ) {
-        if ( ( t == null ) || t.isEmpty() ) {
-            return;
-        }
-        String initial_filename = "";
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();
-        }
-        if ( initial_filename.indexOf( '.' ) > 0 ) {
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );
-        }
-        initial_filename = initial_filename + "." + type;
-        _writetographics_filechooser.setSelectedFile( new File( initial_filename ) );
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _writetographics_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _writetographics_filechooser.showSaveDialog( _contentpane );
-        File file = _writetographics_filechooser.getSelectedFile();
-        setCurrentDir( _writetographics_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( !file.toString().toLowerCase().endsWith( type.toString() ) ) {
-                file = new File( file.toString() + "." + type );
-            }
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "Warning",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
+            catch ( final IOException e ) {
+                JOptionPane.showMessageDialog( this,
+                                               "Could not read from " + url + "\n"
+                                                       + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),
+                                               "Failed to read URL",
+                                               JOptionPane.ERROR_MESSAGE );
+            }
+            catch ( final Exception e ) {
+                JOptionPane.showMessageDialog( this,
+                                               ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),
+                                               "Unexpected Exception",
+                                               JOptionPane.ERROR_MESSAGE );
+            }
+            finally {
+                if ( _mainpanel.getCurrentTreePanel() != null ) {
+                    _mainpanel.getCurrentTreePanel().setArrowCursor();
                 }
                 else {
-                    try {
-                        file.delete();
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Error",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
+                    _mainpanel.setArrowCursor();
                 }
             }
-            writePhylogenyToGraphicsFile( file.toString(), type );
-        }
-    }
-
-    private void writeToPdf( final Phylogeny t ) {
-        if ( ( t == null ) || t.isEmpty() ) {
-            return;
-        }
-        String initial_filename = "";
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();
-        }
-        if ( initial_filename.indexOf( '.' ) > 0 ) {
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );
-        }
-        initial_filename = initial_filename + ".pdf";
-        _writetopdf_filechooser.setSelectedFile( new File( initial_filename ) );
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _writetopdf_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _writetopdf_filechooser.showSaveDialog( _contentpane );
-        File file = _writetopdf_filechooser.getSelectedFile();
-        setCurrentDir( _writetopdf_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( !file.toString().toLowerCase().endsWith( ".pdf" ) ) {
-                file = new File( file.toString() + ".pdf" );
-            }
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "WARNING",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
+            if ( ( phys != null ) && ( phys.length > 0 ) ) {
+                if ( nhx_or_nexus && getOptions().isInternalNumberAreConfidenceForNhParsing() ) {
+                    for( final Phylogeny phy : phys ) {
+                        PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );
+                    }
                 }
+                AptxUtil.addPhylogeniesToTabs( phys,
+                                               new File( url.getFile() ).getName(),
+                                               new File( url.getFile() ).toString(),
+                                               getConfiguration(),
+                                               getMainPanel() );
+                _mainpanel.getControlPanel().showWhole();
             }
-            printPhylogenyToPdf( file.toString() );
-        }
-    }
-
-    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {
-        return new MainFrameApplication( phys, config, title );
-    }
-
-    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {
-        return new MainFrameApplication( phys, config );
-    }
-
-    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {
-        return new MainFrameApplication( phys, config_file_name, title );
-    }
-
-    public static MainFrame createInstance( final Phylogeny[] phys,
-                                            final Configuration config,
-                                            final String title,
-                                            final File current_dir ) {
-        return new MainFrameApplication( phys, config, title, current_dir );
-    }
-
-    static void setTextForGraphicsSizeChooserMenuItem( final JMenuItem mi, final Options o ) {
-        mi.setText( "Enter Default Size for Graphics Export... (current: " + o.getPrintSizeX() + ", "
-                + o.getPrintSizeY() + ")" );
-    }
-
-    static void setTextForPdfLineWidthChooserMenuItem( final JMenuItem mi, final Options o ) {
-        mi.setText( "Enter Default Line Width for PDF Export... (current: " + o.getPrintLineWidth() + ")" );
-    }
-
-    static void warnIfNotPhyloXmlValidation( final Configuration c ) {
-        if ( !c.isValidatePhyloXmlAgainstSchema() ) {
-            JOptionPane
-                    .showMessageDialog( null,
-                                        ForesterUtil
-                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",
-                                                           80 ),
-                                        "Warning",
-                                        JOptionPane.WARNING_MESSAGE );
-        }
-    }
-
-    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {
-        _phylogenetic_inference_options = phylogenetic_inference_options;
-    }
-
-    private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {
-        if ( _phylogenetic_inference_options == null ) {
-            _phylogenetic_inference_options = new PhylogeneticInferenceOptions();
         }
-        return _phylogenetic_inference_options;
-    }
-
-    public Msa getMsa() {
-        return _msa;
+        activateSaveAllIfNeeded();
+        System.gc();
     }
 
     void setMsa( final Msa msa ) {
@@ -2645,15 +2204,7 @@ public final class MainFrameApplication extends MainFrame {
         _msa_file = msa_file;
     }
 
-    public File getMsaFile() {
-        return _msa_file;
-    }
-
-    public List<Sequence> getSeqs() {
-        return _seqs;
-    }
-
-    void setSeqs( final List<Sequence> seqs ) {
+    void setSeqs( final List<MolecularSequence> seqs ) {
         _seqs = seqs;
     }
 
@@ -2661,96 +2212,33 @@ public final class MainFrameApplication extends MainFrame {
         _seqs_file = seqs_file;
     }
 
-    public File getSeqsFile() {
-        return _seqs_file;
-    }
-} // MainFrameApplication.
-
-class NexusFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) || file_name.endsWith( ".nx" )
-                || file_name.endsWith( ".tre" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Nexus files (*.nex, *.nexus, *.nx, *.tre)";
-    }
-} // NexusFilter
-
-class NHFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".tree" ) || file_name.endsWith( ".dnd" )
-                || file_name.endsWith( ".ph" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".nwk" )
-                || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "New Hampshire - Newick files (*.nh, *.newick, *.phy, *.tree, *.dnd, *.tr, *.ph, *.phb, *.nwk)";
-    }
-} // NHFilter
-
-class NHXFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nhx" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "NHX files (*.nhx)";
-    }
-}
-
-class PdfFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        return f.getName().trim().toLowerCase().endsWith( ".pdf" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "PDF files (*.pdf)";
+    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {
+        return new MainFrameApplication( phys, config );
     }
-} // PdfFilter
 
-class TolFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return ( file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" ) || file_name.endsWith( ".zip" ) || f
-                .isDirectory() ) && ( !file_name.endsWith( ".xml.zip" ) );
+    public static MainFrame createInstance( final Phylogeny[] phys,
+                                            final Configuration config,
+                                            final String title,
+                                            final File current_dir ) {
+        return new MainFrameApplication( phys, config, title, current_dir );
     }
 
-    @Override
-    public String getDescription() {
-        return "Tree of Life files (*.tol, *.tolxml)";
+    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {
+        return new MainFrameApplication( phys, config, title );
     }
-} // TolFilter
 
-class XMLFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" ) || file_name.endsWith( "phylo.xml" )
-                || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".zip" ) || f.isDirectory();
+    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {
+        return new MainFrameApplication( phys, config_file_name, title );
     }
 
-    @Override
-    public String getDescription() {
-        return "phyloXML files (*.xml, *.phyloxml, *phylo.xml, *.pxml, *.zip)";
+    static void warnIfNotPhyloXmlValidation( final Configuration c ) {
+        if ( !c.isValidatePhyloXmlAgainstSchema() ) {
+            JOptionPane.showMessageDialog( null,
+                                           ForesterUtil.wordWrap(
+                                                                  "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",
+                                                                  80 ),
+                                           "Warning",
+                                           JOptionPane.WARNING_MESSAGE );
+        }
     }
-} // XMLFilter
+} // MainFrameApplication.