in progress
[jalview.git] / forester / java / src / org / forester / archaeopteryx / MainFrameApplication.java
index 444dd94..29a0a57 100644 (file)
@@ -57,7 +57,6 @@ import javax.swing.UnsupportedLookAndFeelException;
 import javax.swing.WindowConstants;\r
 import javax.swing.event.ChangeEvent;\r
 import javax.swing.event.ChangeListener;\r
-import javax.swing.filechooser.FileFilter;\r
 import javax.swing.plaf.synth.SynthLookAndFeel;\r
 \r
 import org.forester.analysis.TaxonomyDataManager;\r
@@ -93,70 +92,84 @@ import org.forester.phylogeny.PhylogenyMethods;
 import org.forester.phylogeny.PhylogenyNode;\r
 import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;\r
 import org.forester.phylogeny.data.Confidence;\r
+import org.forester.phylogeny.data.PhylogenyDataUtil;\r
+import org.forester.phylogeny.data.Sequence;\r
 import org.forester.phylogeny.data.Taxonomy;\r
 import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;\r
 import org.forester.phylogeny.factories.PhylogenyFactory;\r
 import org.forester.phylogeny.iterators.PhylogenyNodeIterator;\r
-import org.forester.sequence.Sequence;\r
+import org.forester.sequence.MolecularSequence;\r
 import org.forester.util.BasicDescriptiveStatistics;\r
 import org.forester.util.BasicTable;\r
 import org.forester.util.BasicTableParser;\r
 import org.forester.util.DescriptiveStatistics;\r
 import org.forester.util.ForesterUtil;\r
-import org.forester.util.WindowsUtils;\r
 \r
 public final class MainFrameApplication extends MainFrame {\r
 \r
-    static final String                      INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";\r
-    static final String                      OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";\r
-    private final static int                 FRAME_X_SIZE                          = 800;\r
-    private final static int                 FRAME_Y_SIZE                          = 800;\r
+    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {\r
+        return new MainFrameApplication( phys, config );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {\r
+        return new MainFrameApplication( phys, config, title );\r
+    }\r
+\r
+    public static MainFrame createInstance( final Phylogeny[] phys,\r
+                                            final Configuration config,\r
+                                            final String title,\r
+                                            final File current_dir ) {\r
+        return new MainFrameApplication( phys, config, title, current_dir );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {\r
+        return new MainFrameApplication( phys, config_file_name, title );\r
+    }\r
+\r
+    static void warnIfNotPhyloXmlValidation( final Configuration c ) {\r
+        if ( !c.isValidatePhyloXmlAgainstSchema() ) {\r
+            JOptionPane\r
+                    .showMessageDialog( null,\r
+                                        ForesterUtil\r
+                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",\r
+                                                           80 ),\r
+                                        "Warning",\r
+                                        JOptionPane.WARNING_MESSAGE );\r
+        }\r
+    }\r
+    static final String                  INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";\r
+    static final String                  OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";\r
+    private final static int             FRAME_X_SIZE                          = 800;\r
+    private final static int             FRAME_Y_SIZE                          = 800;\r
     // Filters for the file-open dialog (classes defined in this file)\r
-    private final static NHFilter            nhfilter                              = new NHFilter();\r
-    private final static NHXFilter           nhxfilter                             = new NHXFilter();\r
-    private final static XMLFilter           xmlfilter                             = new XMLFilter();\r
-    private final static TolFilter           tolfilter                             = new TolFilter();\r
-    private final static NexusFilter         nexusfilter                           = new NexusFilter();\r
-    private final static PdfFilter           pdffilter                             = new PdfFilter();\r
-    private final static GraphicsFileFilter  graphicsfilefilter                    = new GraphicsFileFilter();\r
-    private final static MsaFileFilter       msafilter                             = new MsaFileFilter();\r
-    private final static SequencesFileFilter seqsfilter                            = new SequencesFileFilter();\r
-    private final static DefaultFilter       defaultfilter                         = new DefaultFilter();\r
-    private static final long                serialVersionUID                      = -799735726778865234L;\r
-    private final JFileChooser               _values_filechooser;\r
-    private final JFileChooser               _sequences_filechooser;\r
-    private final JFileChooser               _open_filechooser;\r
-    private final JFileChooser               _msa_filechooser;\r
-    private final JFileChooser               _seqs_pi_filechooser;\r
-    private final JFileChooser               _open_filechooser_for_species_tree;\r
-    private final JFileChooser               _save_filechooser;\r
-    private final JFileChooser               _writetopdf_filechooser;\r
-    private final JFileChooser               _writetographics_filechooser;\r
+    private static final long            serialVersionUID                      = -799735726778865234L;\r
+    private static final boolean         PREPROCESS_TREES                      = false;\r
+    private final JFileChooser           _values_filechooser;\r
+    private final JFileChooser           _sequences_filechooser;\r
+    private final JFileChooser           _open_filechooser;\r
+    private final JFileChooser           _msa_filechooser;\r
+    private final JFileChooser           _seqs_pi_filechooser;\r
+    private final JFileChooser           _open_filechooser_for_species_tree;\r
     // Application-only print menu items\r
-    private JMenuItem                        _print_item;\r
-    private JMenuItem                        _write_to_pdf_item;\r
-    private JMenuItem                        _write_to_jpg_item;\r
-    private JMenuItem                        _write_to_gif_item;\r
-    private JMenuItem                        _write_to_tif_item;\r
-    private JMenuItem                        _write_to_png_item;\r
-    private JMenuItem                        _write_to_bmp_item;\r
-    private File                             _current_dir;\r
-    private ButtonGroup                      _radio_group_1;\r
-    private ButtonGroup                      _radio_group_2;\r
+    private JMenuItem                    _collapse_below_threshold;\r
+    private JMenuItem                    _collapse_below_branch_length;\r
+    private ButtonGroup                  _radio_group_1;\r
+    private ButtonGroup                  _radio_group_2;\r
     // Others:\r
-    double                                   _min_not_collapse                     = Constants.MIN_NOT_COLLAPSE_DEFAULT;\r
+    double                               _min_not_collapse                     = Constants.MIN_NOT_COLLAPSE_DEFAULT;\r
+    double                               _min_not_collapse_bl                  = 0.001;\r
     // Phylogeny Inference menu\r
-    private JMenu                            _inference_menu;\r
-    private JMenuItem                        _inference_from_msa_item;\r
-    private JMenuItem                        _inference_from_seqs_item;\r
+    private JMenu                        _inference_menu;\r
+    private JMenuItem                    _inference_from_msa_item;\r
+    private JMenuItem                    _inference_from_seqs_item;\r
     // Phylogeny Inference\r
-    private PhylogeneticInferenceOptions     _phylogenetic_inference_options       = null;\r
-    private Msa                              _msa                                  = null;\r
-    private File                             _msa_file                             = null;\r
-    private List<Sequence>                   _seqs                                 = null;\r
-    private File                             _seqs_file                            = null;\r
-    JMenuItem                                _read_values_jmi;\r
-    JMenuItem                                _read_seqs_jmi;\r
+    private PhylogeneticInferenceOptions _phylogenetic_inference_options       = null;\r
+    private Msa                          _msa                                  = null;\r
+    private File                         _msa_file                             = null;\r
+    private List<MolecularSequence>      _seqs                                 = null;\r
+    private File                         _seqs_file                            = null;\r
+    JMenuItem                            _read_values_jmi;\r
+    JMenuItem                            _read_seqs_jmi;\r
 \r
     private MainFrameApplication( final Phylogeny[] phys, final Configuration config ) {\r
         _configuration = config;\r
@@ -271,44 +284,44 @@ public final class MainFrameApplication extends MainFrame {
         _open_filechooser = new JFileChooser();\r
         _open_filechooser.setCurrentDirectory( new File( "." ) );\r
         _open_filechooser.setMultiSelectionEnabled( false );\r
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.xmlfilter );\r
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhxfilter );\r
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );\r
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );\r
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.tolfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrame.xmlfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrame.nhxfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrame.nhfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrame.nexusfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrame.tolfilter );\r
         _open_filechooser.addChoosableFileFilter( _open_filechooser.getAcceptAllFileFilter() );\r
-        _open_filechooser.setFileFilter( MainFrameApplication.defaultfilter );\r
+        _open_filechooser.setFileFilter( MainFrame.defaultfilter );\r
         _open_filechooser_for_species_tree = new JFileChooser();\r
         _open_filechooser_for_species_tree.setCurrentDirectory( new File( "." ) );\r
         _open_filechooser_for_species_tree.setMultiSelectionEnabled( false );\r
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.xmlfilter );\r
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.tolfilter );\r
-        _open_filechooser_for_species_tree.setFileFilter( MainFrameApplication.xmlfilter );\r
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrame.xmlfilter );\r
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrame.tolfilter );\r
+        _open_filechooser_for_species_tree.setFileFilter( MainFrame.xmlfilter );\r
         _save_filechooser = new JFileChooser();\r
         _save_filechooser.setCurrentDirectory( new File( "." ) );\r
         _save_filechooser.setMultiSelectionEnabled( false );\r
-        _save_filechooser.setFileFilter( MainFrameApplication.xmlfilter );\r
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );\r
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );\r
+        _save_filechooser.setFileFilter( MainFrame.xmlfilter );\r
+        _save_filechooser.addChoosableFileFilter( MainFrame.nhfilter );\r
+        _save_filechooser.addChoosableFileFilter( MainFrame.nexusfilter );\r
         _save_filechooser.addChoosableFileFilter( _save_filechooser.getAcceptAllFileFilter() );\r
         _writetopdf_filechooser = new JFileChooser();\r
-        _writetopdf_filechooser.addChoosableFileFilter( MainFrameApplication.pdffilter );\r
+        _writetopdf_filechooser.addChoosableFileFilter( MainFrame.pdffilter );\r
         _writetographics_filechooser = new JFileChooser();\r
-        _writetographics_filechooser.addChoosableFileFilter( MainFrameApplication.graphicsfilefilter );\r
+        _writetographics_filechooser.addChoosableFileFilter( MainFrame.graphicsfilefilter );\r
         // Msa:\r
         _msa_filechooser = new JFileChooser();\r
         _msa_filechooser.setName( "Read Multiple Sequence Alignment File" );\r
         _msa_filechooser.setCurrentDirectory( new File( "." ) );\r
         _msa_filechooser.setMultiSelectionEnabled( false );\r
         _msa_filechooser.addChoosableFileFilter( _msa_filechooser.getAcceptAllFileFilter() );\r
-        _msa_filechooser.addChoosableFileFilter( MainFrameApplication.msafilter );\r
+        _msa_filechooser.addChoosableFileFilter( MainFrame.msafilter );\r
         // Seqs:\r
         _seqs_pi_filechooser = new JFileChooser();\r
         _seqs_pi_filechooser.setName( "Read Sequences File" );\r
         _seqs_pi_filechooser.setCurrentDirectory( new File( "." ) );\r
         _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
         _seqs_pi_filechooser.addChoosableFileFilter( _seqs_pi_filechooser.getAcceptAllFileFilter() );\r
-        _seqs_pi_filechooser.addChoosableFileFilter( MainFrameApplication.seqsfilter );\r
+        _seqs_pi_filechooser.addChoosableFileFilter( MainFrame.seqsfilter );\r
         // Expression\r
         _values_filechooser = new JFileChooser();\r
         _values_filechooser.setCurrentDirectory( new File( "." ) );\r
@@ -383,8 +396,7 @@ public final class MainFrameApplication extends MainFrame {
                     _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel()\r
                                                                                         .getWidth(),\r
                                                                                 _mainpanel.getCurrentTreePanel()\r
-                                                                                        .getHeight(),\r
-                                                                                getOptions().isAllowFontSizeChange() );\r
+                                                                                        .getHeight() );\r
                 }\r
             }\r
         } );\r
@@ -420,11 +432,6 @@ public final class MainFrameApplication extends MainFrame {
             if ( o == _open_url_item ) {\r
                 readPhylogeniesFromURL();\r
             }\r
-            else if ( o == _save_item ) {\r
-                writeToFile( _mainpanel.getCurrentPhylogeny() );\r
-                // If subtree currently displayed, save it, instead of complete\r
-                // tree.\r
-            }\r
             else if ( o == _new_item ) {\r
                 newTree();\r
             }\r
@@ -434,15 +441,9 @@ public final class MainFrameApplication extends MainFrame {
             else if ( o == _close_item ) {\r
                 closeCurrentPane();\r
             }\r
-            else if ( o == _write_to_pdf_item ) {\r
-                writeToPdf( _mainpanel.getCurrentPhylogeny() );\r
-            }\r
             else if ( o == _write_to_jpg_item ) {\r
                 writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.JPG );\r
             }\r
-            else if ( o == _write_to_png_item ) {\r
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.PNG );\r
-            }\r
             else if ( o == _write_to_gif_item ) {\r
                 writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.GIF );\r
             }\r
@@ -504,27 +505,6 @@ public final class MainFrameApplication extends MainFrame {
             else if ( o == _extract_tax_code_from_node_names_jmi ) {\r
                 extractTaxDataFromNodeNames();\r
             }\r
-            else if ( o == _graphics_export_visible_only_cbmi ) {\r
-                updateOptions( getOptions() );\r
-            }\r
-            else if ( o == _antialias_print_cbmi ) {\r
-                updateOptions( getOptions() );\r
-            }\r
-            else if ( o == _print_black_and_white_cbmi ) {\r
-                updateOptions( getOptions() );\r
-            }\r
-            else if ( o == _print_using_actual_size_cbmi ) {\r
-                updateOptions( getOptions() );\r
-            }\r
-            else if ( o == _graphics_export_using_actual_size_cbmi ) {\r
-                updateOptions( getOptions() );\r
-            }\r
-            else if ( o == _print_size_mi ) {\r
-                choosePrintSize();\r
-            }\r
-            else if ( o == _choose_pdf_width_mi ) {\r
-                choosePdfWidth();\r
-            }\r
             else if ( o == _internal_number_are_confidence_for_nh_parsing_cbmi ) {\r
                 updateOptions( getOptions() );\r
             }\r
@@ -543,6 +523,12 @@ public final class MainFrameApplication extends MainFrame {
                 }\r
                 collapseBelowThreshold();\r
             }\r
+            else if ( o == _collapse_below_branch_length ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                collapseBelowBranchLengthThreshold();\r
+            }\r
             else if ( ( o == _extract_taxonomy_pfam_strict_rbmi ) || ( o == _extract_taxonomy_pfam_relaxed_rbmi )\r
                     || ( o == _extract_taxonomy_agressive_rbmi ) ) {\r
                 if ( _replace_underscores_cbmi != null ) {\r
@@ -569,144 +555,144 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    public void end() {\r
-        _mainpanel.terminate();\r
-        _contentpane.removeAll();\r
-        setVisible( false );\r
-        dispose();\r
-    }\r
-\r
-    @Override\r
-    public MainPanel getMainPanel() {\r
-        return _mainpanel;\r
-    }\r
-\r
-    public Msa getMsa() {\r
-        return _msa;\r
-    }\r
-\r
-    public File getMsaFile() {\r
-        return _msa_file;\r
-    }\r
-\r
-    public List<Sequence> getSeqs() {\r
-        return _seqs;\r
-    }\r
-\r
-    public File getSeqsFile() {\r
-        return _seqs_file;\r
-    }\r
-\r
-    public void readMsaFromFile() {\r
-        // Set an initial directory if none set yet\r
+    private void addExpressionValuesFromFile() {\r
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Need to load evolutionary tree first",\r
+                                           "Can Not Read Expression Values",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+            return;\r
+        }\r
         final File my_dir = getCurrentDir();\r
-        _msa_filechooser.setMultiSelectionEnabled( false );\r
-        // Open file-open dialog and set current directory\r
         if ( my_dir != null ) {\r
-            _msa_filechooser.setCurrentDirectory( my_dir );\r
+            _values_filechooser.setCurrentDirectory( my_dir );\r
         }\r
-        final int result = _msa_filechooser.showOpenDialog( _contentpane );\r
-        // All done: get the msa\r
-        final File file = _msa_filechooser.getSelectedFile();\r
-        setCurrentDir( _msa_filechooser.getCurrentDirectory() );\r
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            setMsaFile( null );\r
-            setMsa( null );\r
-            Msa msa = null;\r
+        final int result = _values_filechooser.showOpenDialog( _contentpane );\r
+        final File file = _values_filechooser.getSelectedFile();\r
+        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            BasicTable<String> t = null;\r
             try {\r
-                final InputStream is = new FileInputStream( file );\r
-                if ( FastaParser.isLikelyFasta( file ) ) {\r
-                    msa = FastaParser.parseMsa( is );\r
+                t = BasicTableParser.parse( file, '\t' );\r
+                if ( t.getNumberOfColumns() < 2 ) {\r
+                    t = BasicTableParser.parse( file, ',' );\r
                 }\r
-                else {\r
-                    msa = GeneralMsaParser.parse( is );\r
+                if ( t.getNumberOfColumns() < 2 ) {\r
+                    t = BasicTableParser.parse( file, ' ' );\r
                 }\r
             }\r
-            catch ( final MsaFormatException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Multiple sequence alignment format error",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
             catch ( final IOException e ) {\r
-                setArrowCursor();\r
                 JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Failed to read multiple sequence alignment",\r
+                                               e.getMessage(),\r
+                                               "Could Not Read Expression Value Table",\r
                                                JOptionPane.ERROR_MESSAGE );\r
                 return;\r
             }\r
-            catch ( final IllegalArgumentException e ) {\r
-                setArrowCursor();\r
+            if ( t.getNumberOfColumns() < 2 ) {\r
                 JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               "Table contains " + t.getNumberOfColumns() + " column(s)",\r
+                                               "Problem with Expression Value Table",\r
                                                JOptionPane.ERROR_MESSAGE );\r
                 return;\r
             }\r
-            catch ( final Exception e ) {\r
-                setArrowCursor();\r
-                e.printStackTrace();\r
+            if ( t.getNumberOfRows() < 1 ) {\r
                 JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               "Table contains zero rows",\r
+                                               "Problem with Expression Value Table",\r
                                                JOptionPane.ERROR_MESSAGE );\r
                 return;\r
             }\r
-            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( t.getNumberOfRows() != phy.getNumberOfExternalNodes() ) {\r
                 JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment is empty",\r
-                                               "Illegal Multiple Sequence Alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
+                                               "Table contains " + t.getNumberOfRows() + " rows, but tree contains "\r
+                                                       + phy.getNumberOfExternalNodes() + " external nodes",\r
+                                               "Warning",\r
+                                               JOptionPane.WARNING_MESSAGE );\r
             }\r
-            if ( msa.getNumberOfSequences() < 4 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment needs to contain at least 3 sequences",\r
-                                               "Illegal multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
+            final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
+            int not_found = 0;\r
+            for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+                final PhylogenyNode node = iter.next();\r
+                final String node_name = node.getName();\r
+                if ( !ForesterUtil.isEmpty( node_name ) ) {\r
+                    int row = -1;\r
+                    try {\r
+                        row = t.findRow( node_name );\r
+                    }\r
+                    catch ( final IllegalArgumentException e ) {\r
+                        JOptionPane\r
+                                .showMessageDialog( this,\r
+                                                    e.getMessage(),\r
+                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",\r
+                                                    JOptionPane.ERROR_MESSAGE );\r
+                        return;\r
+                    }\r
+                    if ( row < 0 ) {\r
+                        if ( node.isExternal() ) {\r
+                            not_found++;\r
+                        }\r
+                        continue;\r
+                    }\r
+                    final List<Double> l = new ArrayList<Double>();\r
+                    for( int col = 1; col < t.getNumberOfColumns(); ++col ) {\r
+                        double d = -100;\r
+                        try {\r
+                            d = Double.parseDouble( t.getValueAsString( col, row ) );\r
+                        }\r
+                        catch ( final NumberFormatException e ) {\r
+                            JOptionPane.showMessageDialog( this,\r
+                                                           "Could not parse \"" + t.getValueAsString( col, row )\r
+                                                                   + "\" into a decimal value",\r
+                                                           "Issue with Expression Value Table",\r
+                                                           JOptionPane.ERROR_MESSAGE );\r
+                            return;\r
+                        }\r
+                        stats.addValue( d );\r
+                        l.add( d );\r
+                    }\r
+                    if ( !l.isEmpty() ) {\r
+                        if ( node.getNodeData().getProperties() != null ) {\r
+                            node.getNodeData().getProperties()\r
+                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );\r
+                        }\r
+                        node.getNodeData().setVector( l );\r
+                    }\r
+                }\r
             }\r
-            if ( msa.getLength() < 2 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment needs to contain at least 2 residues",\r
-                                               "Illegal multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
+            if ( not_found > 0 ) {\r
+                JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found\r
+                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );\r
             }\r
-            System.gc();\r
-            setMsaFile( _msa_filechooser.getSelectedFile() );\r
-            setMsa( msa );\r
+            getCurrentTreePanel().setStatisticsForExpressionValues( stats );\r
         }\r
     }\r
 \r
-    public void readSeqsFromFileforPI() {\r
-        // Set an initial directory if none set yet\r
+    private void addSequencesFromFile() {\r
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Need to load evolutionary tree first",\r
+                                           "Can Not Read Sequences",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+            return;\r
+        }\r
         final File my_dir = getCurrentDir();\r
-        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
-        // Open file-open dialog and set current directory\r
         if ( my_dir != null ) {\r
-            _seqs_pi_filechooser.setCurrentDirectory( my_dir );\r
+            _sequences_filechooser.setCurrentDirectory( my_dir );\r
         }\r
-        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );\r
-        // All done: get the seqs\r
-        final File file = _seqs_pi_filechooser.getSelectedFile();\r
-        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );\r
+        final int result = _sequences_filechooser.showOpenDialog( _contentpane );\r
+        final File file = _sequences_filechooser.getSelectedFile();\r
+        List<MolecularSequence> seqs = null;\r
         if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            setSeqsFile( null );\r
-            setSeqs( null );\r
-            List<Sequence> seqs = null;\r
             try {\r
                 if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
                     seqs = FastaParser.parse( new FileInputStream( file ) );\r
-                    for( final Sequence seq : seqs ) {\r
-                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );\r
-                    }\r
                 }\r
                 else {\r
-                    //TODO error\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Format does not appear to be Fasta",\r
+                                                   "Multiple sequence file format error",\r
+                                                   JOptionPane.ERROR_MESSAGE );\r
+                    return;\r
                 }\r
             }\r
             catch ( final MsaFormatException e ) {\r
@@ -725,47 +711,118 @@ public final class MainFrameApplication extends MainFrame {
                                                JOptionPane.ERROR_MESSAGE );\r
                 return;\r
             }\r
-            catch ( final IllegalArgumentException e ) {\r
+            catch ( final Exception e ) {\r
                 setArrowCursor();\r
+                e.printStackTrace();\r
                 JOptionPane.showMessageDialog( this,\r
                                                e.getLocalizedMessage(),\r
                                                "Unexpected error during reading of multiple sequence file",\r
                                                JOptionPane.ERROR_MESSAGE );\r
                 return;\r
             }\r
-            catch ( final Exception e ) {\r
-                setArrowCursor();\r
-                e.printStackTrace();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
                 JOptionPane.showMessageDialog( this,\r
                                                "Multiple sequence file is empty",\r
-                                               "Illegal multiple sequence file",\r
+                                               "Empty multiple sequence file",\r
                                                JOptionPane.ERROR_MESSAGE );\r
+                setArrowCursor();\r
                 return;\r
             }\r
-            if ( seqs.size() < 4 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence file needs to contain at least 3 sequences",\r
-                                               "Illegal multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
+        }\r
+        if ( seqs != null ) {\r
+            for( final MolecularSequence seq : seqs ) {\r
+                System.out.println( seq.getIdentifier() );\r
+            }\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            int total_counter = 0;\r
+            int attached_counter = 0;\r
+            for( final MolecularSequence seq : seqs ) {\r
+                ++total_counter;\r
+                final String seq_name = seq.getIdentifier();\r
+                if ( !ForesterUtil.isEmpty( seq_name ) ) {\r
+                    List<PhylogenyNode> nodes = phy.getNodesViaSequenceName( seq_name );\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodesViaSequenceSymbol( seq_name );\r
+                    }\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodesViaGeneName( seq_name );\r
+                    }\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodes( seq_name );\r
+                    }\r
+                    if ( nodes.size() > 1 ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Sequence name \"" + seq_name + "\" is not unique",\r
+                                                       "Sequence name not unique",\r
+                                                       JOptionPane.ERROR_MESSAGE );\r
+                        setArrowCursor();\r
+                        return;\r
+                    }\r
+                    final String[] a = seq_name.split( "\\s" );\r
+                    if ( nodes.isEmpty() && ( a.length > 1 ) ) {\r
+                        final String seq_name_split = a[ 0 ];\r
+                        nodes = phy.getNodesViaSequenceName( seq_name_split );\r
+                        if ( nodes.isEmpty() ) {\r
+                            nodes = phy.getNodesViaSequenceSymbol( seq_name_split );\r
+                        }\r
+                        if ( nodes.isEmpty() ) {\r
+                            nodes = phy.getNodes( seq_name_split );\r
+                        }\r
+                        if ( nodes.size() > 1 ) {\r
+                            JOptionPane.showMessageDialog( this, "Split sequence name \"" + seq_name_split\r
+                                    + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );\r
+                            setArrowCursor();\r
+                            return;\r
+                        }\r
+                    }\r
+                    if ( nodes.size() == 1 ) {\r
+                        ++attached_counter;\r
+                        final PhylogenyNode n = nodes.get( 0 );\r
+                        if ( !n.getNodeData().isHasSequence() ) {\r
+                            n.getNodeData().addSequence( new org.forester.phylogeny.data.Sequence() );\r
+                        }\r
+                        n.getNodeData().getSequence().setMolecularSequence( seq.getMolecularSequenceAsString() );\r
+                        if ( ForesterUtil.isEmpty( n.getNodeData().getSequence().getName() ) ) {\r
+                            n.getNodeData().getSequence().setName( seq_name );\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+            if ( attached_counter > 0 ) {\r
+                int ext_nodes = 0;\r
+                int ext_nodes_with_seq = 0;\r
+                for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
+                    ++ext_nodes;\r
+                    final PhylogenyNode n = iter.next();\r
+                    if ( n.getNodeData().isHasSequence()\r
+                            && !ForesterUtil.isEmpty( n.getNodeData().getSequence().getMolecularSequence() ) ) {\r
+                        ++ext_nodes_with_seq;\r
+                    }\r
+                }\r
+                final String s;\r
+                if ( ext_nodes == ext_nodes_with_seq ) {\r
+                    s = "All " + ext_nodes_with_seq + " external nodes now have a molecular sequence attached to them.";\r
+                }\r
+                else {\r
+                    s = ext_nodes_with_seq + " out of " + ext_nodes\r
+                            + " external nodes now have a molecular sequence attached to them.";\r
+                }\r
+                if ( ( attached_counter == total_counter ) && ( ext_nodes == ext_nodes_with_seq ) ) {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Attached all " + total_counter + " sequences to tree nodes.\n" + s,\r
+                                                   "All sequences attached",\r
+                                                   JOptionPane.INFORMATION_MESSAGE );\r
+                }\r
+                else {\r
+                    JOptionPane.showMessageDialog( this, "Attached " + attached_counter\r
+                            + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter\r
+                            + " sequences attached", JOptionPane.WARNING_MESSAGE );\r
+                }\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this, "No maching tree node for any of the " + total_counter\r
+                        + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );\r
             }\r
-            //  if ( msa.getLength() < 2 ) {\r
-            //       JOptionPane.showMessageDialog( this,\r
-            //                                      "Multiple sequence alignment needs to contain at least 2 residues",\r
-            //                                      "Illegal multiple sequence file",\r
-            //                                      JOptionPane.ERROR_MESSAGE );\r
-            //       return;\r
-            //   }\r
-            System.gc();\r
-            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );\r
-            setSeqs( seqs );\r
         }\r
     }\r
 \r
@@ -866,18 +923,19 @@ public final class MainFrameApplication extends MainFrame {
                         .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );\r
                 MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame\r
                         .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );\r
-                setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );\r
-                setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );\r
-                MainFrame.updateOptionsMenuDependingOnPhylogenyType( getMainPanel(),\r
-                                                                     _show_scale_cbmi,\r
-                                                                     _show_branch_length_values_cbmi,\r
-                                                                     _non_lined_up_cladograms_rbmi,\r
-                                                                     _uniform_cladograms_rbmi,\r
-                                                                     _ext_node_dependent_cladogram_rbmi,\r
-                                                                     _label_direction_cbmi );\r
+                MainFrame.setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );\r
+                MainFrame.setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );\r
                 MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );\r
                 MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );\r
+                MainFrame.setCycleDataReturnMenuItem( _cycle_data_return, getOptions() );\r
                 MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );\r
+                try {\r
+                    getMainPanel().getControlPanel().setVisibilityOfDomainStrucureCB();\r
+                    getMainPanel().getControlPanel().setVisibilityOfX();\r
+                }\r
+                catch ( final Exception ignore ) {\r
+                    // do nothing, not important.\r
+                }\r
             }\r
         } );\r
         _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );\r
@@ -889,17 +947,18 @@ public final class MainFrameApplication extends MainFrame {
         _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );\r
         _radio_group_1.add( _uniform_cladograms_rbmi );\r
         _radio_group_1.add( _non_lined_up_cladograms_rbmi );\r
-        ///////\r
         _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );\r
         _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );\r
         _options_jmenu\r
-                .add( _show_branch_length_values_cbmi = new JCheckBoxMenuItem( DISPLAY_BRANCH_LENGTH_VALUES_LABEL ) );\r
-        _options_jmenu\r
                 .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );\r
         _options_jmenu\r
                 .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );\r
+        _options_jmenu\r
+                .add( _show_default_node_shapes_for_marked_cbmi = new JCheckBoxMenuItem( MainFrame.DISPLAY_NODE_BOXES_LABEL_MARKED ) );\r
+        _options_jmenu.add( _line_up_renderable_data_cbmi = new JCheckBoxMenuItem( MainFrame.LINE_UP_RENDERABLE_DATA ) );\r
         if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {\r
-            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( SHOW_DOMAIN_LABELS_LABEL ) );\r
+            _options_jmenu.add( _right_line_up_domains_cbmi = new JCheckBoxMenuItem( MainFrame.RIGHT_LINE_UP_DOMAINS ) );\r
+            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( MainFrame.SHOW_DOMAIN_LABELS_LABEL ) );\r
         }\r
         _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );\r
         _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );\r
@@ -918,11 +977,14 @@ public final class MainFrameApplication extends MainFrame {
         _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );\r
         _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );\r
         _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );\r
-        ///////\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( _cycle_data_return = new JMenuItem( "Cycle Data Return" ) );\r
         _options_jmenu.addSeparator();\r
         _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );\r
         _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );\r
         _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );\r
+        _options_jmenu.add( _search_with_regex_cbmi = new JCheckBoxMenuItem( MainFrame.SEARCH_REGEX_LABEL ) );\r
+        _search_with_regex_cbmi.setToolTipText( MainFrame.SEARCH_WITH_REGEX_TIP );\r
         _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );\r
         _options_jmenu.addSeparator();\r
         _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),\r
@@ -944,7 +1006,6 @@ public final class MainFrameApplication extends MainFrame {
         _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );\r
         _options_jmenu\r
                 .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );\r
-        //\r
         _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );\r
         _options_jmenu\r
                 .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );\r
@@ -963,7 +1024,6 @@ public final class MainFrameApplication extends MainFrame {
         _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );\r
         _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );\r
         _radio_group_2.add( _extract_taxonomy_agressive_rbmi );\r
-        // \r
         _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );\r
         _options_jmenu\r
                 .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );\r
@@ -981,9 +1041,12 @@ public final class MainFrameApplication extends MainFrame {
                 .isShowDefaultNodeShapesExternal() );\r
         customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi, getOptions()\r
                 .isShowDefaultNodeShapesInternal() );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_for_marked_cbmi, getOptions()\r
+                .isShowDefaultNodeShapesForMarkedNodes() );\r
         customizeJMenuItem( _cycle_node_shape_mi );\r
         customizeJMenuItem( _cycle_node_fill_mi );\r
         customizeJMenuItem( _choose_node_size_mi );\r
+        customizeJMenuItem( _cycle_data_return );\r
         customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );\r
         customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );\r
         customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );\r
@@ -999,7 +1062,6 @@ public final class MainFrameApplication extends MainFrame {
                                       getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );\r
         customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,\r
                                       getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );\r
-        customizeCheckBoxMenuItem( _show_branch_length_values_cbmi, getOptions().isShowBranchLengthValues() );\r
         customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );\r
         customizeCheckBoxMenuItem( _label_direction_cbmi,\r
                                    getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );\r
@@ -1018,6 +1080,7 @@ public final class MainFrameApplication extends MainFrame {
         customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );\r
         customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi, getOptions()\r
                 .isReplaceUnderscoresInNhParsing() );\r
+        customizeCheckBoxMenuItem( _search_with_regex_cbmi, getOptions().isSearchWithRegex() );\r
         customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );\r
         customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );\r
         customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );\r
@@ -1029,6 +1092,8 @@ public final class MainFrameApplication extends MainFrame {
                 .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );\r
         customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()\r
                 .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );\r
+        customizeCheckBoxMenuItem( _line_up_renderable_data_cbmi, getOptions().isLineUpRendarableNodeData() );\r
+        customizeCheckBoxMenuItem( _right_line_up_domains_cbmi, getOptions().isRightLineUpDomains() );\r
         _jmenubar.add( _options_jmenu );\r
     }\r
 \r
@@ -1082,16 +1147,23 @@ public final class MainFrameApplication extends MainFrame {
         customizeJMenuItem( _delete_selected_nodes_item );\r
         _tools_menu.add( _delete_not_selected_nodes_item = new JMenuItem( "Retain Selected Nodes" ) );\r
         _delete_not_selected_nodes_item.setToolTipText( "To delete all not selected external nodes" );\r
-        \r
         customizeJMenuItem( _delete_not_selected_nodes_item );\r
         _tools_menu.addSeparator();\r
         _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );\r
         customizeJMenuItem( _collapse_species_specific_subtrees );\r
+        _collapse_species_specific_subtrees.setToolTipText( "To (reversibly) collapse species-specific subtrees" );\r
         _tools_menu\r
                 .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );\r
         customizeJMenuItem( _collapse_below_threshold );\r
         _collapse_below_threshold\r
-                .setToolTipText( "To collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );\r
+                .setToolTipText( "To (permanently) collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );\r
+        //\r
+        _tools_menu\r
+                .add( _collapse_below_branch_length = new JMenuItem( "Collapse Branches with Branch Lengths Below Threshold into Multifurcations" ) );\r
+        customizeJMenuItem( _collapse_below_branch_length );\r
+        _collapse_below_branch_length\r
+                .setToolTipText( "To (permanently) collapse branches with branches with branch lengths below a threshold into multifurcations" );\r
+        //\r
         _tools_menu.addSeparator();\r
         _tools_menu\r
                 .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );\r
@@ -1145,559 +1217,176 @@ public final class MainFrameApplication extends MainFrame {
         exit();\r
     }\r
 \r
-    void executeLineageInference() {\r
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {\r
-            return;\r
-        }\r
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
-            JOptionPane.showMessageDialog( this,\r
-                                           "Phylogeny is not rooted.",\r
-                                           "Cannot infer ancestral taxonomies",\r
-                                           JOptionPane.ERROR_MESSAGE );\r
-            return;\r
+    private void closeCurrentPane() {\r
+        if ( getMainPanel().getCurrentTreePanel() != null ) {\r
+            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {\r
+                final int r = JOptionPane.showConfirmDialog( this,\r
+                                                             "Close tab despite potentially unsaved changes?",\r
+                                                             "Close Tab?",\r
+                                                             JOptionPane.YES_NO_OPTION );\r
+                if ( r != JOptionPane.YES_OPTION ) {\r
+                    return;\r
+                }\r
+            }\r
+            getMainPanel().closeCurrentPane();\r
+            activateSaveAllIfNeeded();\r
         }\r
-        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,\r
-                                                                                  _mainpanel.getCurrentTreePanel(),\r
-                                                                                  _mainpanel.getCurrentPhylogeny()\r
-                                                                                          .copy() );\r
-        new Thread( inferrer ).start();\r
-    }\r
-\r
-    void exit() {\r
-        removeAllTextFrames();\r
-        _mainpanel.terminate();\r
-        _contentpane.removeAll();\r
-        setVisible( false );\r
-        dispose();\r
-        System.exit( 0 );\r
     }\r
 \r
-    void readPhylogeniesFromURL() {\r
-        URL url = null;\r
-        Phylogeny[] phys = null;\r
-        final String message = "Please enter a complete URL, for example \"http://purl.org/phylo/treebase/phylows/study/TB2:S15480?format=nexus\"";\r
-        final String url_string = JOptionPane.showInputDialog( this,\r
-                                                               message,\r
-                                                               "Use URL/webservice to obtain a phylogeny",\r
-                                                               JOptionPane.QUESTION_MESSAGE );\r
-        boolean nhx_or_nexus = false;\r
-        if ( ( url_string != null ) && ( url_string.length() > 0 ) ) {\r
-            try {\r
-                url = new URL( url_string );\r
-                PhylogenyParser parser = null;\r
-                if ( url.getHost().toLowerCase().indexOf( "tolweb" ) >= 0 ) {\r
-                    parser = new TolParser();\r
-                }\r
-                else {\r
-                    parser = ParserUtils.createParserDependingOnUrlContents( url, getConfiguration()\r
-                            .isValidatePhyloXmlAgainstSchema() );\r
-                }\r
-                if ( parser instanceof NexusPhylogeniesParser ) {\r
-                    nhx_or_nexus = true;\r
-                }\r
-                else if ( parser instanceof NHXParser ) {\r
-                    nhx_or_nexus = true;\r
-                }\r
-                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
-                    _mainpanel.getCurrentTreePanel().setWaitCursor();\r
-                }\r
-                else {\r
-                    _mainpanel.setWaitCursor();\r
+    private void collapse( final Phylogeny phy ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
+        double min_support = Double.MAX_VALUE;\r
+        boolean conf_present = false;\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                final List<Confidence> c = n.getBranchData().getConfidences();\r
+                if ( ( c != null ) && ( c.size() > 0 ) ) {\r
+                    conf_present = true;\r
+                    double max = 0;\r
+                    for( final Confidence confidence : c ) {\r
+                        if ( confidence.getValue() > max ) {\r
+                            max = confidence.getValue();\r
+                        }\r
+                    }\r
+                    if ( max < getMinNotCollapseConfidenceValue() ) {\r
+                        to_be_removed.add( n );\r
+                    }\r
+                    if ( max < min_support ) {\r
+                        min_support = max;\r
+                    }\r
                 }\r
-                final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();\r
-                phys = factory.create( url.openStream(), parser );\r
             }\r
-            catch ( final MalformedURLException e ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Malformed URL: " + url + "\n" + e.getLocalizedMessage(),\r
-                                               "Malformed URL",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
+        }\r
+        if ( conf_present ) {\r
+            for( final PhylogenyNode node : to_be_removed ) {\r
+                PhylogenyMethods.removeNode( node, phy );\r
             }\r
-            catch ( final IOException e ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Could not read from " + url + "\n"\r
-                                                       + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
-                                               "Failed to read URL",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
+            if ( to_be_removed.size() > 0 ) {\r
+                phy.externalNodesHaveChanged();\r
+                phy.clearHashIdToNodeMap();\r
+                phy.recalculateNumberOfExternalDescendants( true );\r
+                getCurrentTreePanel().resetNodeIdToDistToLeafMap();\r
+                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();\r
+                getCurrentTreePanel().calculateLongestExtNodeInfo();\r
+                getCurrentTreePanel().setNodeInPreorderToNull();\r
+                getCurrentTreePanel().recalculateMaxDistanceToRoot();\r
+                getCurrentTreePanel().resetPreferredSize();\r
+                getCurrentTreePanel().setEdited( true );\r
+                getCurrentTreePanel().repaint();\r
+                repaint();\r
             }\r
-            catch ( final Exception e ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
-                                               "Unexpected Exception",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-            }\r
-            finally {\r
-                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
-                    _mainpanel.getCurrentTreePanel().setArrowCursor();\r
-                }\r
-                else {\r
-                    _mainpanel.setArrowCursor();\r
-                }\r
-            }\r
-            if ( ( phys != null ) && ( phys.length > 0 ) ) {\r
-                if ( nhx_or_nexus && getOptions().isInternalNumberAreConfidenceForNhParsing() ) {\r
-                    for( final Phylogeny phy : phys ) {\r
-                        \r
-                        PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );\r
-                    }\r
-                }\r
-                AptxUtil.addPhylogeniesToTabs( phys,\r
-                                               new File( url.getFile() ).getName(),\r
-                                               new File( url.getFile() ).toString(),\r
-                                               getConfiguration(),\r
-                                               getMainPanel() );\r
-                _mainpanel.getControlPanel().showWhole();\r
-            }\r
-        }\r
-        activateSaveAllIfNeeded();\r
-        System.gc();\r
-    }\r
-\r
-    void setMsa( final Msa msa ) {\r
-        _msa = msa;\r
-    }\r
-\r
-    void setMsaFile( final File msa_file ) {\r
-        _msa_file = msa_file;\r
-    }\r
-\r
-    void setSeqs( final List<Sequence> seqs ) {\r
-        _seqs = seqs;\r
-    }\r
-\r
-    void setSeqsFile( final File seqs_file ) {\r
-        _seqs_file = seqs_file;\r
-    }\r
-\r
-    void writePhylogenyToGraphicsFile( final String file_name, final GraphicsExportType type ) {\r
-        _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel().getWidth(),\r
-                                                                    _mainpanel.getCurrentTreePanel().getHeight(),\r
-                                                                    true );\r
-        String file_written_to = "";\r
-        boolean error = false;\r
-        try {\r
-            file_written_to = AptxUtil.writePhylogenyToGraphicsFile( file_name,\r
-                                                                     _mainpanel.getCurrentTreePanel().getWidth(),\r
-                                                                     _mainpanel.getCurrentTreePanel().getHeight(),\r
-                                                                     _mainpanel.getCurrentTreePanel(),\r
-                                                                     _mainpanel.getControlPanel(),\r
-                                                                     type,\r
-                                                                     getOptions() );\r
-        }\r
-        catch ( final IOException e ) {\r
-            error = true;\r
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );\r
-        }\r
-        if ( !error ) {\r
-            if ( ( file_written_to != null ) && ( file_written_to.length() > 0 ) ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Wrote image to: " + file_written_to,\r
-                                               "Graphics Export",\r
-                                               JOptionPane.INFORMATION_MESSAGE );\r
+            if ( to_be_removed.size() > 0 ) {\r
+                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
+                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "\r
+                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
             }\r
             else {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "There was an unknown problem when attempting to write to an image file: \""\r
-                                                       + file_name + "\"",\r
-                                               "Error",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
+                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "\r
+                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );\r
             }\r
         }\r
-        _contentpane.repaint();\r
-    }\r
-\r
-    private void addExpressionValuesFromFile() {\r
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
+        else {\r
             JOptionPane.showMessageDialog( this,\r
-                                           "Need to load evolutionary tree first",\r
-                                           "Can Not Read Expression Values",\r
-                                           JOptionPane.WARNING_MESSAGE );\r
-            return;\r
-        }\r
-        final File my_dir = getCurrentDir();\r
-        if ( my_dir != null ) {\r
-            _values_filechooser.setCurrentDirectory( my_dir );\r
+                                           "No branch collapsed because no confidence values present",\r
+                                           "No confidence values present",\r
+                                           JOptionPane.INFORMATION_MESSAGE );\r
         }\r
-        final int result = _values_filechooser.showOpenDialog( _contentpane );\r
-        final File file = _values_filechooser.getSelectedFile();\r
-        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            BasicTable<String> t = null;\r
-            try {\r
-                t = BasicTableParser.parse( file, '\t' );\r
-                if ( t.getNumberOfColumns() < 2 ) {\r
-                    t = BasicTableParser.parse( file, ',' );\r
-                }\r
-                if ( t.getNumberOfColumns() < 2 ) {\r
-                    t = BasicTableParser.parse( file, ' ' );\r
-                }\r
-            }\r
-            catch ( final IOException e ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getMessage(),\r
-                                               "Could Not Read Expression Value Table",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( t.getNumberOfColumns() < 2 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Table contains " + t.getNumberOfColumns() + " column(s)",\r
-                                               "Problem with Expression Value Table",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( t.getNumberOfRows() < 1 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Table contains zero rows",\r
-                                               "Problem with Expression Value Table",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
+    }\r
+\r
+    private void collapseBelowBranchLengthThreshold() {\r
+        if ( getCurrentTreePanel() != null ) {\r
             final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
-            if ( t.getNumberOfRows() != phy.getNumberOfExternalNodes() ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Table contains " + t.getNumberOfRows() + " rows, but tree contains "\r
-                                                       + phy.getNumberOfExternalNodes() + " external nodes",\r
-                                               "Warning",\r
-                                               JOptionPane.WARNING_MESSAGE );\r
-            }\r
-            final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
-            int not_found = 0;\r
-            for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
-                final PhylogenyNode node = iter.next();\r
-                final String node_name = node.getName();\r
-                if ( !ForesterUtil.isEmpty( node_name ) ) {\r
-                    int row = -1;\r
-                    try {\r
-                        row = t.findRow( node_name );\r
-                    }\r
-                    catch ( final IllegalArgumentException e ) {\r
-                        JOptionPane\r
-                                .showMessageDialog( this,\r
-                                                    e.getMessage(),\r
-                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",\r
-                                                    JOptionPane.ERROR_MESSAGE );\r
-                        return;\r
-                    }\r
-                    if ( row < 0 ) {\r
-                        if ( node.isExternal() ) {\r
-                            not_found++;\r
-                        }\r
-                        continue;\r
-                    }\r
-                    final List<Double> l = new ArrayList<Double>();\r
-                    for( int col = 1; col < t.getNumberOfColumns(); ++col ) {\r
-                        double d = -100;\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final String s = ( String ) JOptionPane\r
+                        .showInputDialog( this,\r
+                                          "Please enter the minimum branch length value\n",\r
+                                          "Minimal Branch Length Value",\r
+                                          JOptionPane.QUESTION_MESSAGE,\r
+                                          null,\r
+                                          null,\r
+                                          getMinNotCollapseBlValue() );\r
+                if ( !ForesterUtil.isEmpty( s ) ) {\r
+                    boolean success = true;\r
+                    double m = 0.0;\r
+                    final String m_str = s.trim();\r
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
                         try {\r
-                            d = Double.parseDouble( t.getValueAsString( col, row ) );\r
+                            m = Double.parseDouble( m_str );\r
                         }\r
-                        catch ( final NumberFormatException e ) {\r
-                            JOptionPane.showMessageDialog( this,\r
-                                                           "Could not parse \"" + t.getValueAsString( col, row )\r
-                                                                   + "\" into a decimal value",\r
-                                                           "Issue with Expression Value Table",\r
-                                                           JOptionPane.ERROR_MESSAGE );\r
-                            return;\r
+                        catch ( final Exception ex ) {\r
+                            success = false;\r
                         }\r
-                        stats.addValue( d );\r
-                        l.add( d );\r
                     }\r
-                    if ( !l.isEmpty() ) {\r
-                        if ( node.getNodeData().getProperties() != null ) {\r
-                            node.getNodeData().getProperties()\r
-                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );\r
-                        }\r
-                        node.getNodeData().setVector( l );\r
+                    else {\r
+                        success = false;\r
+                    }\r
+                    if ( success && ( m >= 0.0 ) ) {\r
+                        setMinNotCollapseBlValue( m );\r
+                        collapseBl( phy );\r
                     }\r
                 }\r
             }\r
-            if ( not_found > 0 ) {\r
-                JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found\r
-                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );\r
-            }\r
-            getCurrentTreePanel().setStatisticsForExpressionValues( stats );\r
         }\r
     }\r
 \r
-    private void addSequencesFromFile() {\r
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
-            JOptionPane.showMessageDialog( this,\r
-                                           "Need to load evolutionary tree first",\r
-                                           "Can Not Read Sequences",\r
-                                           JOptionPane.WARNING_MESSAGE );\r
-            return;\r
-        }\r
-        final File my_dir = getCurrentDir();\r
-        if ( my_dir != null ) {\r
-            _sequences_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _sequences_filechooser.showOpenDialog( _contentpane );\r
-        final File file = _sequences_filechooser.getSelectedFile();\r
-        List<Sequence> seqs = null;\r
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            try {\r
-                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
-                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
-                }\r
-                else {\r
-                    JOptionPane.showMessageDialog( this,\r
-                                                   "Format does not appear to be Fasta",\r
-                                                   "Multiple sequence file format error",\r
-                                                   JOptionPane.ERROR_MESSAGE );\r
-                    return;\r
-                }\r
-            }\r
-            catch ( final MsaFormatException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Multiple sequence file format error",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final IOException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Failed to read multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final Exception e ) {\r
-                setArrowCursor();\r
-                e.printStackTrace();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence file is empty",\r
-                                               "Empty multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                setArrowCursor();\r
-                return;\r
-            }\r
-        }\r
-        if ( seqs != null ) {\r
-            for( final Sequence seq : seqs ) {\r
-                System.out.println( seq.getIdentifier() );\r
-            }\r
+    private void collapseBelowThreshold() {\r
+        if ( getCurrentTreePanel() != null ) {\r
             final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
-            int total_counter = 0;\r
-            int attached_counter = 0;\r
-            for( final Sequence seq : seqs ) {\r
-                ++total_counter;\r
-                final String seq_name = seq.getIdentifier();\r
-                if ( !ForesterUtil.isEmpty( seq_name ) ) {\r
-                    List<PhylogenyNode> nodes = phy.getNodesViaSequenceName( seq_name );\r
-                    if ( nodes.isEmpty() ) {\r
-                        nodes = phy.getNodesViaSequenceSymbol( seq_name );\r
-                    }\r
-                    if ( nodes.isEmpty() ) {\r
-                        nodes = phy.getNodesViaGeneName( seq_name );\r
-                    }\r
-                    if ( nodes.isEmpty() ) {\r
-                        nodes = phy.getNodes( seq_name );\r
-                    }\r
-                    if ( nodes.size() > 1 ) {\r
-                        JOptionPane.showMessageDialog( this,\r
-                                                       "Sequence name \"" + seq_name + "\" is not unique",\r
-                                                       "Sequence name not unique",\r
-                                                       JOptionPane.ERROR_MESSAGE );\r
-                        setArrowCursor();\r
-                        return;\r
-                    }\r
-                    final String[] a = seq_name.split( "\\s" );\r
-                    if ( nodes.isEmpty() && ( a.length > 1 ) ) {\r
-                        final String seq_name_split = a[ 0 ];\r
-                        nodes = phy.getNodesViaSequenceName( seq_name_split );\r
-                        if ( nodes.isEmpty() ) {\r
-                            nodes = phy.getNodesViaSequenceSymbol( seq_name_split );\r
-                        }\r
-                        if ( nodes.isEmpty() ) {\r
-                            nodes = phy.getNodes( seq_name_split );\r
-                        }\r
-                        if ( nodes.size() > 1 ) {\r
-                            JOptionPane.showMessageDialog( this, "Split sequence name \"" + seq_name_split\r
-                                    + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );\r
-                            setArrowCursor();\r
-                            return;\r
-                        }\r
-                    }\r
-                    if ( nodes.size() == 1 ) {\r
-                        ++attached_counter;\r
-                        final PhylogenyNode n = nodes.get( 0 );\r
-                        if ( !n.getNodeData().isHasSequence() ) {\r
-                            n.getNodeData().addSequence( new org.forester.phylogeny.data.Sequence() );\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final String s = ( String ) JOptionPane.showInputDialog( this,\r
+                                                                         "Please enter the minimum confidence value\n",\r
+                                                                         "Minimal Confidence Value",\r
+                                                                         JOptionPane.QUESTION_MESSAGE,\r
+                                                                         null,\r
+                                                                         null,\r
+                                                                         getMinNotCollapseConfidenceValue() );\r
+                if ( !ForesterUtil.isEmpty( s ) ) {\r
+                    boolean success = true;\r
+                    double m = 0.0;\r
+                    final String m_str = s.trim();\r
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                        try {\r
+                            m = Double.parseDouble( m_str );\r
                         }\r
-                        n.getNodeData().getSequence().setMolecularSequence( seq.getMolecularSequenceAsString() );\r
-                        if ( ForesterUtil.isEmpty( n.getNodeData().getSequence().getName() ) ) {\r
-                            n.getNodeData().getSequence().setName( seq_name );\r
+                        catch ( final Exception ex ) {\r
+                            success = false;\r
                         }\r
                     }\r
-                }\r
-            }\r
-            if ( attached_counter > 0 ) {\r
-                int ext_nodes = 0;\r
-                int ext_nodes_with_seq = 0;\r
-                for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
-                    ++ext_nodes;\r
-                    final PhylogenyNode n = iter.next();\r
-                    if ( n.getNodeData().isHasSequence()\r
-                            && !ForesterUtil.isEmpty( n.getNodeData().getSequence().getMolecularSequence() ) ) {\r
-                        ++ext_nodes_with_seq;\r
-                    }\r
-                }\r
-                final String s;\r
-                if ( ext_nodes == ext_nodes_with_seq ) {\r
-                    s = "All " + ext_nodes_with_seq + " external nodes now have a molecular sequence attached to them.";\r
-                }\r
-                else {\r
-                    s = ext_nodes_with_seq + " out of " + ext_nodes\r
-                            + " external nodes now have a molecular sequence attached to them.";\r
-                }\r
-                if ( ( attached_counter == total_counter ) && ( ext_nodes == ext_nodes_with_seq ) ) {\r
-                    JOptionPane.showMessageDialog( this,\r
-                                                   "Attached all " + total_counter + " sequences to tree nodes.\n" + s,\r
-                                                   "All sequences attached",\r
-                                                   JOptionPane.INFORMATION_MESSAGE );\r
-                }\r
-                else {\r
-                    JOptionPane.showMessageDialog( this, "Attached " + attached_counter\r
-                            + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter\r
-                            + " sequences attached", JOptionPane.WARNING_MESSAGE );\r
-                }\r
-            }\r
-            else {\r
-                JOptionPane.showMessageDialog( this, "No maching tree node for any of the " + total_counter\r
-                        + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );\r
-            }\r
-        }\r
-    }\r
-\r
-    private void choosePdfWidth() {\r
-        final String s = ( String ) JOptionPane.showInputDialog( this,\r
-                                                                 "Please enter the default line width for PDF export.\n"\r
-                                                                         + "[current value: "\r
-                                                                         + getOptions().getPrintLineWidth() + "]\n",\r
-                                                                 "Line Width for PDF Export",\r
-                                                                 JOptionPane.QUESTION_MESSAGE,\r
-                                                                 null,\r
-                                                                 null,\r
-                                                                 getOptions().getPrintLineWidth() );\r
-        if ( !ForesterUtil.isEmpty( s ) ) {\r
-            boolean success = true;\r
-            float f = 0.0f;\r
-            final String m_str = s.trim();\r
-            if ( !ForesterUtil.isEmpty( m_str ) ) {\r
-                try {\r
-                    f = Float.parseFloat( m_str );\r
-                }\r
-                catch ( final Exception ex ) {\r
-                    success = false;\r
-                }\r
-            }\r
-            else {\r
-                success = false;\r
-            }\r
-            if ( success && ( f > 0.0 ) ) {\r
-                getOptions().setPrintLineWidth( f );\r
-            }\r
-        }\r
-    }\r
-\r
-    private void choosePrintSize() {\r
-        final String s = ( String ) JOptionPane.showInputDialog( this,\r
-                                                                 "Please enter values for width and height,\nseparated by a comma.\n"\r
-                                                                         + "[current values: "\r
-                                                                         + getOptions().getPrintSizeX() + ", "\r
-                                                                         + getOptions().getPrintSizeY() + "]\n"\r
-                                                                         + "[A4: " + Constants.A4_SIZE_X + ", "\r
-                                                                         + Constants.A4_SIZE_Y + "]\n" + "[US Letter: "\r
-                                                                         + Constants.US_LETTER_SIZE_X + ", "\r
-                                                                         + Constants.US_LETTER_SIZE_Y + "]",\r
-                                                                 "Default Size for Graphics Export",\r
-                                                                 JOptionPane.QUESTION_MESSAGE,\r
-                                                                 null,\r
-                                                                 null,\r
-                                                                 getOptions().getPrintSizeX() + ", "\r
-                                                                         + getOptions().getPrintSizeY() );\r
-        if ( !ForesterUtil.isEmpty( s ) && ( s.indexOf( ',' ) > 0 ) ) {\r
-            boolean success = true;\r
-            int x = 0;\r
-            int y = 0;\r
-            final String[] str_ary = s.split( "," );\r
-            if ( str_ary.length == 2 ) {\r
-                final String x_str = str_ary[ 0 ].trim();\r
-                final String y_str = str_ary[ 1 ].trim();\r
-                if ( !ForesterUtil.isEmpty( x_str ) && !ForesterUtil.isEmpty( y_str ) ) {\r
-                    try {\r
-                        x = Integer.parseInt( x_str );\r
-                        y = Integer.parseInt( y_str );\r
-                    }\r
-                    catch ( final Exception ex ) {\r
+                    else {\r
                         success = false;\r
                     }\r
+                    if ( success && ( m >= 0.0 ) ) {\r
+                        setMinNotCollapseConfidenceValue( m );\r
+                        collapse( phy );\r
+                    }\r
                 }\r
-                else {\r
-                    success = false;\r
-                }\r
-            }\r
-            else {\r
-                success = false;\r
-            }\r
-            if ( success && ( x > 1 ) && ( y > 1 ) ) {\r
-                getOptions().setPrintSizeX( x );\r
-                getOptions().setPrintSizeY( y );\r
             }\r
         }\r
     }\r
 \r
-    private void closeCurrentPane() {\r
-        if ( getMainPanel().getCurrentTreePanel() != null ) {\r
-            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {\r
-                final int r = JOptionPane.showConfirmDialog( this,\r
-                                                             "Close tab despite potentially unsaved changes?",\r
-                                                             "Close Tab?",\r
-                                                             JOptionPane.YES_NO_OPTION );\r
-                if ( r != JOptionPane.YES_OPTION ) {\r
-                    return;\r
-                }\r
-            }\r
-            getMainPanel().closeCurrentPane();\r
-            activateSaveAllIfNeeded();\r
-        }\r
-    }\r
-\r
-    private void collapse( final Phylogeny phy, final double m ) {\r
+    private void collapseBl( final Phylogeny phy ) {\r
         final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
         final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
-        double min_support = Double.MAX_VALUE;\r
-        boolean conf_present = false;\r
+        double min_bl = Double.MAX_VALUE;\r
+        boolean bl_present = false;\r
         while ( it.hasNext() ) {\r
             final PhylogenyNode n = it.next();\r
             if ( !n.isExternal() && !n.isRoot() ) {\r
-                final List<Confidence> c = n.getBranchData().getConfidences();\r
-                if ( ( c != null ) && ( c.size() > 0 ) ) {\r
-                    conf_present = true;\r
-                    double max = 0;\r
-                    for( final Confidence confidence : c ) {\r
-                        if ( confidence.getValue() > max ) {\r
-                            max = confidence.getValue();\r
-                        }\r
-                    }\r
-                    if ( max < getMinNotCollapseConfidenceValue() ) {\r
+                final double bl = n.getDistanceToParent();\r
+                if ( bl != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {\r
+                    bl_present = true;\r
+                    if ( bl < getMinNotCollapseBlValue() ) {\r
                         to_be_removed.add( n );\r
                     }\r
-                    if ( max < min_support ) {\r
-                        min_support = max;\r
+                    if ( bl < min_bl ) {\r
+                        min_bl = bl;\r
                     }\r
                 }\r
             }\r
         }\r
-        if ( conf_present ) {\r
+        if ( bl_present ) {\r
             for( final PhylogenyNode node : to_be_removed ) {\r
                 PhylogenyMethods.removeNode( node, phy );\r
             }\r
@@ -1717,57 +1406,24 @@ public final class MainFrameApplication extends MainFrame {
             }\r
             if ( to_be_removed.size() > 0 ) {\r
                 JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
-                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "\r
+                        + " branches with\nbranch length values below " + getMinNotCollapseBlValue(), "Collapsed "\r
                         + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
             }\r
             else {\r
-                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "\r
-                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "No branch collapsed,\nminimum branch length is " + min_bl,\r
+                                               "No branch collapsed",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
             }\r
         }\r
         else {\r
             JOptionPane.showMessageDialog( this,\r
-                                           "No branch collapsed because no confidence values present",\r
-                                           "No confidence values present",\r
+                                           "No branch collapsed because no branch length values present",\r
+                                           "No branch length values present",\r
                                            JOptionPane.INFORMATION_MESSAGE );\r
         }\r
     }\r
 \r
-    private void collapseBelowThreshold() {\r
-        if ( getCurrentTreePanel() != null ) {\r
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
-            if ( ( phy != null ) && !phy.isEmpty() ) {\r
-                final String s = ( String ) JOptionPane.showInputDialog( this,\r
-                                                                         "Please enter the minimum confidence value\n",\r
-                                                                         "Minimal Confidence Value",\r
-                                                                         JOptionPane.QUESTION_MESSAGE,\r
-                                                                         null,\r
-                                                                         null,\r
-                                                                         getMinNotCollapseConfidenceValue() );\r
-                if ( !ForesterUtil.isEmpty( s ) ) {\r
-                    boolean success = true;\r
-                    double m = 0.0;\r
-                    final String m_str = s.trim();\r
-                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
-                        try {\r
-                            m = Double.parseDouble( m_str );\r
-                        }\r
-                        catch ( final Exception ex ) {\r
-                            success = false;\r
-                        }\r
-                    }\r
-                    else {\r
-                        success = false;\r
-                    }\r
-                    if ( success && ( m >= 0.0 ) ) {\r
-                        setMinNotCollapseConfidenceValue( m );\r
-                        collapse( phy, m );\r
-                    }\r
-                }\r
-            }\r
-        }\r
-    }\r
-\r
     private PhyloXmlParser createPhyloXmlParser() {\r
         PhyloXmlParser xml_parser = null;\r
         if ( getConfiguration().isValidatePhyloXmlAgainstSchema() ) {\r
@@ -1787,6 +1443,31 @@ public final class MainFrameApplication extends MainFrame {
         return xml_parser;\r
     }\r
 \r
+    public void end() {\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+    }\r
+\r
+    void executeLineageInference() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {\r
+            return;\r
+        }\r
+        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Phylogeny is not rooted.",\r
+                                           "Cannot infer ancestral taxonomies",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,\r
+                                                                                  _mainpanel.getCurrentTreePanel(),\r
+                                                                                  _mainpanel.getCurrentPhylogeny()\r
+                                                                                          .copy() );\r
+        new Thread( inferrer ).start();\r
+    }\r
+\r
     private void executePhyleneticInference( final boolean from_unaligned_seqs ) {\r
         final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,\r
                                                                       getPhylogeneticInferenceOptions(),\r
@@ -1824,6 +1505,15 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
+    void exit() {\r
+        removeAllTextFrames();\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+        // System.exit( 0 ); //TODO reconfirm that this is OK, then remove.\r
+    }\r
+\r
     private void extractTaxDataFromNodeNames() throws PhyloXmlDataFormatException {\r
         final StringBuilder sb = new StringBuilder();\r
         final StringBuilder sb_failed = new StringBuilder();\r
@@ -1887,36 +1577,27 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    private ControlPanel getControlPanel() {\r
-        return getMainPanel().getControlPanel();\r
+    @Override\r
+    public MainPanel getMainPanel() {\r
+        return _mainpanel;\r
     }\r
 \r
-    private File getCurrentDir() {\r
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {\r
-            if ( ForesterUtil.isWindows() ) {\r
-                try {\r
-                    _current_dir = new File( WindowsUtils.getCurrentUserDesktopPath() );\r
-                }\r
-                catch ( final Exception e ) {\r
-                    _current_dir = null;\r
-                }\r
-            }\r
-        }\r
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {\r
-            if ( System.getProperty( "user.home" ) != null ) {\r
-                _current_dir = new File( System.getProperty( "user.home" ) );\r
-            }\r
-            else if ( System.getProperty( "user.dir" ) != null ) {\r
-                _current_dir = new File( System.getProperty( "user.dir" ) );\r
-            }\r
-        }\r
-        return _current_dir;\r
+    private double getMinNotCollapseBlValue() {\r
+        return _min_not_collapse_bl;\r
     }\r
 \r
     private double getMinNotCollapseConfidenceValue() {\r
         return _min_not_collapse;\r
     }\r
 \r
+    public Msa getMsa() {\r
+        return _msa;\r
+    }\r
+\r
+    public File getMsaFile() {\r
+        return _msa_file;\r
+    }\r
+\r
     private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {\r
         if ( _phylogenetic_inference_options == null ) {\r
             _phylogenetic_inference_options = new PhylogeneticInferenceOptions();\r
@@ -1924,6 +1605,14 @@ public final class MainFrameApplication extends MainFrame {
         return _phylogenetic_inference_options;\r
     }\r
 \r
+    public List<MolecularSequence> getSeqs() {\r
+        return _seqs;\r
+    }\r
+\r
+    public File getSeqsFile() {\r
+        return _seqs_file;\r
+    }\r
+\r
     private boolean isUnsavedDataPresent() {\r
         final List<TreePanel> tps = getMainPanel().getTreePanels();\r
         for( final TreePanel tp : tps ) {\r
@@ -2018,6 +1707,30 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
+    private void preProcessTreesUponReading( final Phylogeny[] phys ) {\r
+        for( final Phylogeny phy : phys ) {\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {\r
+                    final PhylogenyNode n = it.next();\r
+                    if ( n.isExternal() ) {\r
+                        if ( n.getNodeData().isHasSequence() ) {\r
+                            final Sequence s = n.getNodeData().getSequence();\r
+                            if ( ForesterUtil.isEmpty( s.getGeneName() ) || s.getGeneName().startsWith( "LOC" ) ) {\r
+                                if ( ( s.getAccession() != null )\r
+                                        && !ForesterUtil.isEmpty( s.getAccession().getValue() ) ) {\r
+                                    s.setGeneName( s.getAccession().getValue() );\r
+                                }\r
+                                else if ( !ForesterUtil.isEmpty( n.getName() ) ) {\r
+                                    s.setGeneName( n.getName() );\r
+                                }\r
+                            }\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
     private void print() {\r
         if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null )\r
                 || getCurrentTreePanel().getPhylogeny().isEmpty() ) {\r
@@ -2025,8 +1738,7 @@ public final class MainFrameApplication extends MainFrame {
         }\r
         if ( !getOptions().isPrintUsingActualSize() ) {\r
             getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX() - 80,\r
-                                                             getOptions().getPrintSizeY() - 140,\r
-                                                             true );\r
+                                                             getOptions().getPrintSizeY() - 140 );\r
             getCurrentTreePanel().resetPreferredSize();\r
             getCurrentTreePanel().repaint();\r
         }\r
@@ -2052,49 +1764,88 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    private void printPhylogenyToPdf( final String file_name ) {\r
-        if ( !getOptions().isPrintUsingActualSize() ) {\r
-            getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX(),\r
-                                                             getOptions().getPrintSizeY(),\r
-                                                             true );\r
-            getCurrentTreePanel().resetPreferredSize();\r
-            getCurrentTreePanel().repaint();\r
+    public void readMsaFromFile() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _msa_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _msa_filechooser.setCurrentDirectory( my_dir );\r
         }\r
-        String pdf_written_to = "";\r
-        boolean error = false;\r
-        try {\r
-            if ( getOptions().isPrintUsingActualSize() ) {\r
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name,\r
-                                                                  getCurrentTreePanel(),\r
-                                                                  getCurrentTreePanel().getWidth(),\r
-                                                                  getCurrentTreePanel().getHeight() );\r
+        final int result = _msa_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the msa\r
+        final File file = _msa_filechooser.getSelectedFile();\r
+        setCurrentDir( _msa_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setMsaFile( null );\r
+            setMsa( null );\r
+            Msa msa = null;\r
+            try {\r
+                final InputStream is = new FileInputStream( file );\r
+                if ( FastaParser.isLikelyFasta( file ) ) {\r
+                    msa = FastaParser.parseMsa( is );\r
+                }\r
+                else {\r
+                    msa = GeneralMsaParser.parse( is );\r
+                }\r
             }\r
-            else {\r
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name, getCurrentTreePanel(), getOptions()\r
-                        .getPrintSizeX(), getOptions().getPrintSizeY() );\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence alignment format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
             }\r
-        }\r
-        catch ( final IOException e ) {\r
-            error = true;\r
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );\r
-        }\r
-        if ( !error ) {\r
-            if ( !ForesterUtil.isEmpty( pdf_written_to ) ) {\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
                 JOptionPane.showMessageDialog( this,\r
-                                               "Wrote PDF to: " + pdf_written_to,\r
-                                               "Information",\r
-                                               JOptionPane.INFORMATION_MESSAGE );\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
             }\r
-            else {\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
                 JOptionPane.showMessageDialog( this,\r
-                                               "There was an unknown problem when attempting to write to PDF file: \""\r
-                                                       + file_name + "\"",\r
-                                               "Error",\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
                                                JOptionPane.ERROR_MESSAGE );\r
+                return;\r
             }\r
-        }\r
-        if ( !getOptions().isPrintUsingActualSize() ) {\r
-            getControlPanel().showWhole();\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment is empty",\r
+                                               "Illegal Multiple Sequence Alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getNumberOfSequences() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getLength() < 2 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 2 residues",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            System.gc();\r
+            setMsaFile( _msa_filechooser.getSelectedFile() );\r
+            setMsa( msa );\r
         }\r
     }\r
 \r
@@ -2122,8 +1873,8 @@ public final class MainFrameApplication extends MainFrame {
                     else {\r
                         _mainpanel.setWaitCursor();\r
                     }\r
-                    if ( ( _open_filechooser.getFileFilter() == MainFrameApplication.nhfilter )\r
-                            || ( _open_filechooser.getFileFilter() == MainFrameApplication.nhxfilter ) ) {\r
+                    if ( ( _open_filechooser.getFileFilter() == MainFrame.nhfilter )\r
+                            || ( _open_filechooser.getFileFilter() == MainFrame.nhxfilter ) ) {\r
                         try {\r
                             final NHXParser nhx = new NHXParser();\r
                             setSpecialOptionsForNhxParser( nhx );\r
@@ -2135,7 +1886,7 @@ public final class MainFrameApplication extends MainFrame {
                             exceptionOccuredDuringOpenFile( e );\r
                         }\r
                     }\r
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.xmlfilter ) {\r
                         warnIfNotPhyloXmlValidation( getConfiguration() );\r
                         try {\r
                             final PhyloXmlParser xml_parser = createPhyloXmlParser();\r
@@ -2146,7 +1897,7 @@ public final class MainFrameApplication extends MainFrame {
                             exceptionOccuredDuringOpenFile( e );\r
                         }\r
                     }\r
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.tolfilter ) {\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.tolfilter ) {\r
                         try {\r
                             phys = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
                         }\r
@@ -2155,7 +1906,7 @@ public final class MainFrameApplication extends MainFrame {
                             exceptionOccuredDuringOpenFile( e );\r
                         }\r
                     }\r
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrame.nexusfilter ) {\r
                         try {\r
                             final NexusPhylogeniesParser nex = new NexusPhylogeniesParser();\r
                             setSpecialOptionsForNexParser( nex );\r
@@ -2212,6 +1963,9 @@ public final class MainFrameApplication extends MainFrame {
                                 }\r
                             }\r
                         }\r
+                        if ( PREPROCESS_TREES ) {\r
+                            preProcessTreesUponReading( phys );\r
+                        }\r
                         AptxUtil.addPhylogeniesToTabs( phys,\r
                                                        file.getName(),\r
                                                        file.getAbsolutePath(),\r
@@ -2231,8 +1985,175 @@ public final class MainFrameApplication extends MainFrame {
                 }\r
             }\r
         }\r
-        activateSaveAllIfNeeded();\r
-        System.gc();\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    void readPhylogeniesFromURL() {\r
+        URL url = null;\r
+        Phylogeny[] phys = null;\r
+        final String message = "Please enter a complete URL, for example \"http://purl.org/phylo/treebase/phylows/study/TB2:S15480?format=nexus\"";\r
+        final String url_string = JOptionPane.showInputDialog( this,\r
+                                                               message,\r
+                                                               "Use URL/webservice to obtain a phylogeny",\r
+                                                               JOptionPane.QUESTION_MESSAGE );\r
+        boolean nhx_or_nexus = false;\r
+        if ( ( url_string != null ) && ( url_string.length() > 0 ) ) {\r
+            try {\r
+                url = new URL( url_string );\r
+                PhylogenyParser parser = null;\r
+                if ( url.getHost().toLowerCase().indexOf( "tolweb" ) >= 0 ) {\r
+                    parser = new TolParser();\r
+                }\r
+                else {\r
+                    parser = ParserUtils.createParserDependingOnUrlContents( url, getConfiguration()\r
+                            .isValidatePhyloXmlAgainstSchema() );\r
+                }\r
+                if ( parser instanceof NexusPhylogeniesParser ) {\r
+                    nhx_or_nexus = true;\r
+                }\r
+                else if ( parser instanceof NHXParser ) {\r
+                    nhx_or_nexus = true;\r
+                }\r
+                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                    _mainpanel.getCurrentTreePanel().setWaitCursor();\r
+                }\r
+                else {\r
+                    _mainpanel.setWaitCursor();\r
+                }\r
+                final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();\r
+                phys = factory.create( url.openStream(), parser );\r
+            }\r
+            catch ( final MalformedURLException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Malformed URL: " + url + "\n" + e.getLocalizedMessage(),\r
+                                               "Malformed URL",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            catch ( final IOException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Could not read from " + url + "\n"\r
+                                                       + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
+                                               "Failed to read URL",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            catch ( final Exception e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
+                                               "Unexpected Exception",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            finally {\r
+                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                    _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+                }\r
+                else {\r
+                    _mainpanel.setArrowCursor();\r
+                }\r
+            }\r
+            if ( ( phys != null ) && ( phys.length > 0 ) ) {\r
+                if ( nhx_or_nexus && getOptions().isInternalNumberAreConfidenceForNhParsing() ) {\r
+                    for( final Phylogeny phy : phys ) {\r
+                        PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );\r
+                    }\r
+                }\r
+                AptxUtil.addPhylogeniesToTabs( phys,\r
+                                               new File( url.getFile() ).getName(),\r
+                                               new File( url.getFile() ).toString(),\r
+                                               getConfiguration(),\r
+                                               getMainPanel() );\r
+                _mainpanel.getControlPanel().showWhole();\r
+            }\r
+        }\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    public void readSeqsFromFileforPI() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _seqs_pi_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the seqs\r
+        final File file = _seqs_pi_filechooser.getSelectedFile();\r
+        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setSeqsFile( null );\r
+            setSeqs( null );\r
+            List<MolecularSequence> seqs = null;\r
+            try {\r
+                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
+                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
+                    for( final MolecularSequence seq : seqs ) {\r
+                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );\r
+                    }\r
+                }\r
+                else {\r
+                    //TODO error\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence file format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file is empty",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( seqs.size() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            //  if ( msa.getLength() < 2 ) {\r
+            //       JOptionPane.showMessageDialog( this,\r
+            //                                      "Multiple sequence alignment needs to contain at least 2 residues",\r
+            //                                      "Illegal multiple sequence file",\r
+            //                                      JOptionPane.ERROR_MESSAGE );\r
+            //       return;\r
+            //   }\r
+            System.gc();\r
+            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );\r
+            setSeqs( seqs );\r
+        }\r
     }\r
 \r
     private void readSpeciesTreeFromFile() {\r
@@ -2246,7 +2167,7 @@ public final class MainFrameApplication extends MainFrame {
         final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );\r
         final File file = _open_filechooser_for_species_tree.getSelectedFile();\r
         if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
+            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.xmlfilter ) {\r
                 try {\r
                     final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
                             .createPhyloXmlParserXsdValidating(), file );\r
@@ -2257,7 +2178,7 @@ public final class MainFrameApplication extends MainFrame {
                     exceptionOccuredDuringOpenFile( e );\r
                 }\r
             }\r
-            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.tolfilter ) {\r
+            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.tolfilter ) {\r
                 try {\r
                     final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
                     t = trees[ 0 ];\r
@@ -2340,18 +2261,34 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    private void setCurrentDir( final File current_dir ) {\r
-        _current_dir = current_dir;\r
+    private void setMinNotCollapseBlValue( final double min_not_collapse_bl ) {\r
+        _min_not_collapse_bl = min_not_collapse_bl;\r
     }\r
 \r
     private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {\r
         _min_not_collapse = min_not_collapse;\r
     }\r
 \r
+    void setMsa( final Msa msa ) {\r
+        _msa = msa;\r
+    }\r
+\r
+    void setMsaFile( final File msa_file ) {\r
+        _msa_file = msa_file;\r
+    }\r
+\r
     private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {\r
         _phylogenetic_inference_options = phylogenetic_inference_options;\r
     }\r
 \r
+    void setSeqs( final List<MolecularSequence> seqs ) {\r
+        _seqs = seqs;\r
+    }\r
+\r
+    void setSeqsFile( final File seqs_file ) {\r
+        _seqs_file = seqs_file;\r
+    }\r
+\r
     private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {\r
         nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
         nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
@@ -2420,413 +2357,4 @@ public final class MainFrameApplication extends MainFrame {
             }\r
         }\r
     }\r
-\r
-    private boolean writeAsNewHampshire( final Phylogeny t, boolean exception, final File file ) {\r
-        try {\r
-            final PhylogenyWriter writer = new PhylogenyWriter();\r
-            writer.toNewHampshire( t, true, getOptions().getNhConversionSupportValueStyle(), file );\r
-        }\r
-        catch ( final Exception e ) {\r
-            exception = true;\r
-            exceptionOccuredDuringSaveAs( e );\r
-        }\r
-        return exception;\r
-    }\r
-\r
-    private boolean writeAsNexus( final Phylogeny t, boolean exception, final File file ) {\r
-        try {\r
-            final PhylogenyWriter writer = new PhylogenyWriter();\r
-            writer.toNexus( file, t, getOptions().getNhConversionSupportValueStyle() );\r
-        }\r
-        catch ( final Exception e ) {\r
-            exception = true;\r
-            exceptionOccuredDuringSaveAs( e );\r
-        }\r
-        return exception;\r
-    }\r
-\r
-    private boolean writeAsPhyloXml( final Phylogeny t, boolean exception, final File file ) {\r
-        try {\r
-            final PhylogenyWriter writer = new PhylogenyWriter();\r
-            writer.toPhyloXML( file, t, 0 );\r
-        }\r
-        catch ( final Exception e ) {\r
-            exception = true;\r
-            exceptionOccuredDuringSaveAs( e );\r
-        }\r
-        return exception;\r
-    }\r
-\r
-    private void writeToFile( final Phylogeny t ) {\r
-        if ( t == null ) {\r
-            return;\r
-        }\r
-        String initial_filename = null;\r
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
-            try {\r
-                initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().getCanonicalPath();\r
-            }\r
-            catch ( final IOException e ) {\r
-                initial_filename = null;\r
-            }\r
-        }\r
-        if ( !ForesterUtil.isEmpty( initial_filename ) ) {\r
-            _save_filechooser.setSelectedFile( new File( initial_filename ) );\r
-        }\r
-        else {\r
-            _save_filechooser.setSelectedFile( new File( "" ) );\r
-        }\r
-        final File my_dir = getCurrentDir();\r
-        if ( my_dir != null ) {\r
-            _save_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _save_filechooser.showSaveDialog( _contentpane );\r
-        final File file = _save_filechooser.getSelectedFile();\r
-        setCurrentDir( _save_filechooser.getCurrentDirectory() );\r
-        boolean exception = false;\r
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            if ( file.exists() ) {\r
-                final int i = JOptionPane.showConfirmDialog( this,\r
-                                                             file + " already exists.\nOverwrite?",\r
-                                                             "Overwrite?",\r
-                                                             JOptionPane.OK_CANCEL_OPTION,\r
-                                                             JOptionPane.QUESTION_MESSAGE );\r
-                if ( i != JOptionPane.OK_OPTION ) {\r
-                    return;\r
-                }\r
-                else {\r
-                    final File to = new File( file.getAbsoluteFile().toString() + Constants.BACKUP_FILE_SUFFIX );\r
-                    try {\r
-                        ForesterUtil.copyFile( file, to );\r
-                    }\r
-                    catch ( final Exception e ) {\r
-                        JOptionPane.showMessageDialog( this,\r
-                                                       "Failed to create backup copy " + to,\r
-                                                       "Failed to Create Backup Copy",\r
-                                                       JOptionPane.WARNING_MESSAGE );\r
-                    }\r
-                    try {\r
-                        file.delete();\r
-                    }\r
-                    catch ( final Exception e ) {\r
-                        JOptionPane.showMessageDialog( this,\r
-                                                       "Failed to delete: " + file,\r
-                                                       "Failed to Delete",\r
-                                                       JOptionPane.WARNING_MESSAGE );\r
-                    }\r
-                }\r
-            }\r
-            if ( _save_filechooser.getFileFilter() == MainFrameApplication.nhfilter ) {\r
-                exception = writeAsNewHampshire( t, exception, file );\r
-            }\r
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
-                exception = writeAsPhyloXml( t, exception, file );\r
-            }\r
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {\r
-                exception = writeAsNexus( t, exception, file );\r
-            }\r
-            // "*.*":\r
-            else {\r
-                final String file_name = file.getName().trim().toLowerCase();\r
-                if ( file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
-                        || file_name.endsWith( ".tree" ) ) {\r
-                    exception = writeAsNewHampshire( t, exception, file );\r
-                }\r
-                else if ( file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) ) {\r
-                    exception = writeAsNexus( t, exception, file );\r
-                }\r
-                // XML is default:\r
-                else {\r
-                    exception = writeAsPhyloXml( t, exception, file );\r
-                }\r
-            }\r
-            if ( !exception ) {\r
-                getMainPanel().setTitleOfSelectedTab( file.getName() );\r
-                getMainPanel().getCurrentTreePanel().setTreeFile( file );\r
-                getMainPanel().getCurrentTreePanel().setEdited( false );\r
-            }\r
-        }\r
-    }\r
-\r
-    private void writeToGraphicsFile( final Phylogeny t, final GraphicsExportType type ) {\r
-        if ( ( t == null ) || t.isEmpty() ) {\r
-            return;\r
-        }\r
-        String initial_filename = "";\r
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();\r
-        }\r
-        if ( initial_filename.indexOf( '.' ) > 0 ) {\r
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );\r
-        }\r
-        initial_filename = initial_filename + "." + type;\r
-        _writetographics_filechooser.setSelectedFile( new File( initial_filename ) );\r
-        final File my_dir = getCurrentDir();\r
-        if ( my_dir != null ) {\r
-            _writetographics_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _writetographics_filechooser.showSaveDialog( _contentpane );\r
-        File file = _writetographics_filechooser.getSelectedFile();\r
-        setCurrentDir( _writetographics_filechooser.getCurrentDirectory() );\r
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            if ( !file.toString().toLowerCase().endsWith( type.toString() ) ) {\r
-                file = new File( file.toString() + "." + type );\r
-            }\r
-            if ( file.exists() ) {\r
-                final int i = JOptionPane.showConfirmDialog( this,\r
-                                                             file + " already exists. Overwrite?",\r
-                                                             "Warning",\r
-                                                             JOptionPane.OK_CANCEL_OPTION,\r
-                                                             JOptionPane.WARNING_MESSAGE );\r
-                if ( i != JOptionPane.OK_OPTION ) {\r
-                    return;\r
-                }\r
-                else {\r
-                    try {\r
-                        file.delete();\r
-                    }\r
-                    catch ( final Exception e ) {\r
-                        JOptionPane.showMessageDialog( this,\r
-                                                       "Failed to delete: " + file,\r
-                                                       "Error",\r
-                                                       JOptionPane.WARNING_MESSAGE );\r
-                    }\r
-                }\r
-            }\r
-            writePhylogenyToGraphicsFile( file.toString(), type );\r
-        }\r
-    }\r
-\r
-    private void writeToPdf( final Phylogeny t ) {\r
-        if ( ( t == null ) || t.isEmpty() ) {\r
-            return;\r
-        }\r
-        String initial_filename = "";\r
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();\r
-        }\r
-        if ( initial_filename.indexOf( '.' ) > 0 ) {\r
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );\r
-        }\r
-        initial_filename = initial_filename + ".pdf";\r
-        _writetopdf_filechooser.setSelectedFile( new File( initial_filename ) );\r
-        final File my_dir = getCurrentDir();\r
-        if ( my_dir != null ) {\r
-            _writetopdf_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _writetopdf_filechooser.showSaveDialog( _contentpane );\r
-        File file = _writetopdf_filechooser.getSelectedFile();\r
-        setCurrentDir( _writetopdf_filechooser.getCurrentDirectory() );\r
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            if ( !file.toString().toLowerCase().endsWith( ".pdf" ) ) {\r
-                file = new File( file.toString() + ".pdf" );\r
-            }\r
-            if ( file.exists() ) {\r
-                final int i = JOptionPane.showConfirmDialog( this,\r
-                                                             file + " already exists. Overwrite?",\r
-                                                             "WARNING",\r
-                                                             JOptionPane.OK_CANCEL_OPTION,\r
-                                                             JOptionPane.WARNING_MESSAGE );\r
-                if ( i != JOptionPane.OK_OPTION ) {\r
-                    return;\r
-                }\r
-            }\r
-            printPhylogenyToPdf( file.toString() );\r
-        }\r
-    }\r
-\r
-    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {\r
-        return new MainFrameApplication( phys, config );\r
-    }\r
-\r
-    public static MainFrame createInstance( final Phylogeny[] phys,\r
-                                            final Configuration config,\r
-                                            final String title,\r
-                                            final File current_dir ) {\r
-        return new MainFrameApplication( phys, config, title, current_dir );\r
-    }\r
-\r
-    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {\r
-        return new MainFrameApplication( phys, config, title );\r
-    }\r
-\r
-    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {\r
-        return new MainFrameApplication( phys, config_file_name, title );\r
-    }\r
-\r
-    static void setTextForGraphicsSizeChooserMenuItem( final JMenuItem mi, final Options o ) {\r
-        mi.setText( "Enter Default Size for Graphics Export... (current: " + o.getPrintSizeX() + ", "\r
-                + o.getPrintSizeY() + ")" );\r
-    }\r
-\r
-    static void setTextForPdfLineWidthChooserMenuItem( final JMenuItem mi, final Options o ) {\r
-        mi.setText( "Enter Default Line Width for PDF Export... (current: " + o.getPrintLineWidth() + ")" );\r
-    }\r
-\r
-    static void warnIfNotPhyloXmlValidation( final Configuration c ) {\r
-        if ( !c.isValidatePhyloXmlAgainstSchema() ) {\r
-            JOptionPane\r
-                    .showMessageDialog( null,\r
-                                        ForesterUtil\r
-                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",\r
-                                                           80 ),\r
-                                        "Warning",\r
-                                        JOptionPane.WARNING_MESSAGE );\r
-        }\r
-    }\r
 } // MainFrameApplication.\r
-\r
-class DefaultFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
-                || file_name.endsWith( ".nwk" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".ph" )\r
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".dnd" ) || file_name.endsWith( ".tree" )\r
-                || file_name.endsWith( ".nhx" ) || file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" )\r
-                || file_name.endsWith( "phylo.xml" ) || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".nexus" )\r
-                || file_name.endsWith( ".nx" ) || file_name.endsWith( ".nex" ) || file_name.endsWith( ".tre" )\r
-                || file_name.endsWith( ".zip" ) || file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" )\r
-                || file_name.endsWith( ".con" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "All supported files (*.xml, *.phyloxml, *phylo.xml, *.nhx, *.nh, *.newick, *.nex, *.nexus, *.phy, *.tre, *.tree, *.tol, ...)";\r
-    }\r
-}\r
-\r
-class GraphicsFileFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".jpg" ) || file_name.endsWith( ".jpeg" ) || file_name.endsWith( ".png" )\r
-                || file_name.endsWith( ".gif" ) || file_name.endsWith( ".bmp" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "Image files (*.jpg, *.jpeg, *.png, *.gif, *.bmp)";\r
-    }\r
-}\r
-\r
-class MsaFileFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".msa" ) || file_name.endsWith( ".aln" ) || file_name.endsWith( ".fasta" )\r
-                || file_name.endsWith( ".fas" ) || file_name.endsWith( ".fa" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "Multiple sequence alignment files (*.msa, *.aln, *.fasta, *.fa, *.fas)";\r
-    }\r
-}\r
-\r
-class NexusFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) || file_name.endsWith( ".nx" )\r
-                || file_name.endsWith( ".tre" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "Nexus files (*.nex, *.nexus, *.nx, *.tre)";\r
-    }\r
-} // NexusFilter\r
-\r
-class NHFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".tree" ) || file_name.endsWith( ".dnd" )\r
-                || file_name.endsWith( ".ph" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".nwk" )\r
-                || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "New Hampshire - Newick files (*.nh, *.newick, *.phy, *.tree, *.dnd, *.tr, *.ph, *.phb, *.nwk)";\r
-    }\r
-} // NHFilter\r
-\r
-class NHXFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".nhx" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "NHX files (*.nhx) [deprecated]";\r
-    }\r
-}\r
-\r
-class PdfFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        return f.getName().trim().toLowerCase().endsWith( ".pdf" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "PDF files (*.pdf)";\r
-    }\r
-} // PdfFilter\r
-\r
-class SequencesFileFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".fasta" ) || file_name.endsWith( ".fa" ) || file_name.endsWith( ".fas" )\r
-                || file_name.endsWith( ".seqs" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "Sequences files (*.fasta, *.fa, *.fas, *.seqs )";\r
-    }\r
-}\r
-\r
-class TolFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return ( file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" ) || file_name.endsWith( ".zip" ) || f\r
-                .isDirectory() ) && ( !file_name.endsWith( ".xml.zip" ) );\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "Tree of Life files (*.tol, *.tolxml)";\r
-    }\r
-} // TolFilter\r
-\r
-class XMLFilter extends FileFilter {\r
-\r
-    @Override\r
-    public boolean accept( final File f ) {\r
-        final String file_name = f.getName().trim().toLowerCase();\r
-        return file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" ) || file_name.endsWith( "phylo.xml" )\r
-                || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".zip" ) || f.isDirectory();\r
-    }\r
-\r
-    @Override\r
-    public String getDescription() {\r
-        return "phyloXML files (*.xml, *.phyloxml, *phylo.xml, *.pxml, *.zip)";\r
-    }\r
-} // XMLFilter\r