in progress
[jalview.git] / forester / java / src / org / forester / archaeopteryx / MainFrameApplication.java
index 2588e95..6b2c76c 100644 (file)
@@ -60,7 +60,6 @@ import javax.swing.event.ChangeListener;
 import javax.swing.plaf.synth.SynthLookAndFeel;\r
 \r
 import org.forester.analysis.TaxonomyDataManager;\r
-import org.forester.archaeopteryx.AptxUtil.GraphicsExportType;\r
 import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;\r
 import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;\r
 import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;\r
@@ -83,7 +82,6 @@ import org.forester.io.parsers.phyloxml.PhyloXmlParser;
 import org.forester.io.parsers.phyloxml.PhyloXmlUtil;\r
 import org.forester.io.parsers.tol.TolParser;\r
 import org.forester.io.parsers.util.ParserUtils;\r
-import org.forester.io.writers.PhylogenyWriter;\r
 import org.forester.io.writers.SequenceWriter;\r
 import org.forester.msa.Msa;\r
 import org.forester.msa.MsaFormatException;\r
@@ -107,36 +105,6 @@ import org.forester.util.ForesterUtil;
 \r
 public final class MainFrameApplication extends MainFrame {\r
 \r
-    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {\r
-        return new MainFrameApplication( phys, config );\r
-    }\r
-\r
-    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {\r
-        return new MainFrameApplication( phys, config, title );\r
-    }\r
-\r
-    public static MainFrame createInstance( final Phylogeny[] phys,\r
-                                            final Configuration config,\r
-                                            final String title,\r
-                                            final File current_dir ) {\r
-        return new MainFrameApplication( phys, config, title, current_dir );\r
-    }\r
-\r
-    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {\r
-        return new MainFrameApplication( phys, config_file_name, title );\r
-    }\r
-\r
-    static void warnIfNotPhyloXmlValidation( final Configuration c ) {\r
-        if ( !c.isValidatePhyloXmlAgainstSchema() ) {\r
-            JOptionPane\r
-                    .showMessageDialog( null,\r
-                                        ForesterUtil\r
-                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",\r
-                                                           80 ),\r
-                                        "Warning",\r
-                                        JOptionPane.WARNING_MESSAGE );\r
-        }\r
-    }\r
     static final String                  INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";\r
     static final String                  OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";\r
     private final static int             FRAME_X_SIZE                          = 800;\r
@@ -394,9 +362,9 @@ public final class MainFrameApplication extends MainFrame {
             public void componentResized( final ComponentEvent e ) {\r
                 if ( _mainpanel.getCurrentTreePanel() != null ) {\r
                     _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel()\r
-                                                                                        .getWidth(),\r
+                                                                                .getWidth(),\r
                                                                                 _mainpanel.getCurrentTreePanel()\r
-                                                                                        .getHeight() );\r
+                                                                                .getHeight() );\r
                 }\r
             }\r
         } );\r
@@ -435,11 +403,9 @@ public final class MainFrameApplication extends MainFrame {
             else if ( o == _new_item ) {\r
                 newTree();\r
             }\r
-           \r
             else if ( o == _close_item ) {\r
                 closeCurrentPane();\r
             }\r
-          \r
             else if ( o == _load_species_tree_item ) {\r
                 readSpeciesTreeFromFile();\r
             }\r
@@ -539,6 +505,206 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
+    public void end() {\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+    }\r
+\r
+    @Override\r
+    public MainPanel getMainPanel() {\r
+        return _mainpanel;\r
+    }\r
+\r
+    public Msa getMsa() {\r
+        return _msa;\r
+    }\r
+\r
+    public File getMsaFile() {\r
+        return _msa_file;\r
+    }\r
+\r
+    public List<MolecularSequence> getSeqs() {\r
+        return _seqs;\r
+    }\r
+\r
+    public File getSeqsFile() {\r
+        return _seqs_file;\r
+    }\r
+\r
+    public void readMsaFromFile() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _msa_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _msa_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _msa_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the msa\r
+        final File file = _msa_filechooser.getSelectedFile();\r
+        setCurrentDir( _msa_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setMsaFile( null );\r
+            setMsa( null );\r
+            Msa msa = null;\r
+            try {\r
+                final InputStream is = new FileInputStream( file );\r
+                if ( FastaParser.isLikelyFasta( file ) ) {\r
+                    msa = FastaParser.parseMsa( is );\r
+                }\r
+                else {\r
+                    msa = GeneralMsaParser.parse( is );\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence alignment format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment is empty",\r
+                                               "Illegal Multiple Sequence Alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getNumberOfSequences() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getLength() < 2 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 2 residues",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            System.gc();\r
+            setMsaFile( _msa_filechooser.getSelectedFile() );\r
+            setMsa( msa );\r
+        }\r
+    }\r
+\r
+    public void readSeqsFromFileforPI() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _seqs_pi_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the seqs\r
+        final File file = _seqs_pi_filechooser.getSelectedFile();\r
+        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setSeqsFile( null );\r
+            setSeqs( null );\r
+            List<MolecularSequence> seqs = null;\r
+            try {\r
+                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
+                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
+                    for( final MolecularSequence seq : seqs ) {\r
+                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );\r
+                    }\r
+                }\r
+                else {\r
+                    //TODO error\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence file format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file is empty",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( seqs.size() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            //  if ( msa.getLength() < 2 ) {\r
+            //       JOptionPane.showMessageDialog( this,\r
+            //                                      "Multiple sequence alignment needs to contain at least 2 residues",\r
+            //                                      "Illegal multiple sequence file",\r
+            //                                      JOptionPane.ERROR_MESSAGE );\r
+            //       return;\r
+            //   }\r
+            System.gc();\r
+            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );\r
+            setSeqs( seqs );\r
+        }\r
+    }\r
+\r
     private void addExpressionValuesFromFile() {\r
         if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
             JOptionPane.showMessageDialog( this,\r
@@ -590,8 +756,8 @@ public final class MainFrameApplication extends MainFrame {
                 JOptionPane.showMessageDialog( this,\r
                                                "Table contains " + t.getNumberOfRows() + " rows, but tree contains "\r
                                                        + phy.getNumberOfExternalNodes() + " external nodes",\r
-                                               "Warning",\r
-                                               JOptionPane.WARNING_MESSAGE );\r
+                                                       "Warning",\r
+                                                       JOptionPane.WARNING_MESSAGE );\r
             }\r
             final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
             int not_found = 0;\r
@@ -605,10 +771,10 @@ public final class MainFrameApplication extends MainFrame {
                     }\r
                     catch ( final IllegalArgumentException e ) {\r
                         JOptionPane\r
-                                .showMessageDialog( this,\r
-                                                    e.getMessage(),\r
-                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",\r
-                                                    JOptionPane.ERROR_MESSAGE );\r
+                        .showMessageDialog( this,\r
+                                            e.getMessage(),\r
+                                            "Error Mapping Node Identifiers to Expression Value Identifiers",\r
+                                            JOptionPane.ERROR_MESSAGE );\r
                         return;\r
                     }\r
                     if ( row < 0 ) {\r
@@ -626,7 +792,7 @@ public final class MainFrameApplication extends MainFrame {
                         catch ( final NumberFormatException e ) {\r
                             JOptionPane.showMessageDialog( this,\r
                                                            "Could not parse \"" + t.getValueAsString( col, row )\r
-                                                                   + "\" into a decimal value",\r
+                                                           + "\" into a decimal value",\r
                                                            "Issue with Expression Value Table",\r
                                                            JOptionPane.ERROR_MESSAGE );\r
                             return;\r
@@ -637,7 +803,7 @@ public final class MainFrameApplication extends MainFrame {
                     if ( !l.isEmpty() ) {\r
                         if ( node.getNodeData().getProperties() != null ) {\r
                             node.getNodeData().getProperties()\r
-                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );\r
+                            .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );\r
                         }\r
                         node.getNodeData().setVector( l );\r
                     }\r
@@ -645,7 +811,7 @@ public final class MainFrameApplication extends MainFrame {
             }\r
             if ( not_found > 0 ) {\r
                 JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found\r
-                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );\r
+                                               + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );\r
             }\r
             getCurrentTreePanel().setStatisticsForExpressionValues( stats );\r
         }\r
@@ -754,7 +920,7 @@ public final class MainFrameApplication extends MainFrame {
                         }\r
                         if ( nodes.size() > 1 ) {\r
                             JOptionPane.showMessageDialog( this, "Split sequence name \"" + seq_name_split\r
-                                    + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );\r
+                                                           + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );\r
                             setArrowCursor();\r
                             return;\r
                         }\r
@@ -799,451 +965,187 @@ public final class MainFrameApplication extends MainFrame {
                 }\r
                 else {\r
                     JOptionPane.showMessageDialog( this, "Attached " + attached_counter\r
-                            + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter\r
-                            + " sequences attached", JOptionPane.WARNING_MESSAGE );\r
+                                                   + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter\r
+                                                   + " sequences attached", JOptionPane.WARNING_MESSAGE );\r
                 }\r
             }\r
             else {\r
                 JOptionPane.showMessageDialog( this, "No maching tree node for any of the " + total_counter\r
-                        + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );\r
+                                               + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );\r
             }\r
         }\r
     }\r
 \r
-    void buildAnalysisMenu() {\r
-        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );\r
-        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );\r
-        _analysis_menu.add( _gsdir_item = new JMenuItem( "GSDIR (GSDI with re-rooting)" ) );\r
-        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );\r
-        customizeJMenuItem( _gsdi_item );\r
-        customizeJMenuItem( _gsdir_item );\r
-        customizeJMenuItem( _load_species_tree_item );\r
-        _analysis_menu.addSeparator();\r
-        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );\r
-        customizeJMenuItem( _lineage_inference );\r
-        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );\r
-        _jmenubar.add( _analysis_menu );\r
+    private void closeCurrentPane() {\r
+        if ( getMainPanel().getCurrentTreePanel() != null ) {\r
+            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {\r
+                final int r = JOptionPane.showConfirmDialog( this,\r
+                                                             "Close tab despite potentially unsaved changes?",\r
+                                                             "Close Tab?",\r
+                                                             JOptionPane.YES_NO_OPTION );\r
+                if ( r != JOptionPane.YES_OPTION ) {\r
+                    return;\r
+                }\r
+            }\r
+            getMainPanel().closeCurrentPane();\r
+            activateSaveAllIfNeeded();\r
+        }\r
     }\r
 \r
-    @Override\r
-    void buildFileMenu() {\r
-        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );\r
-        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _open_url_item = new JMenuItem( "Read Tree from URL/Webservice..." ) );\r
-        _file_jmenu.addSeparator();\r
-        final WebservicesManager webservices_manager = WebservicesManager.getInstance();\r
-        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager\r
-                .getAvailablePhylogeniesWebserviceClients().size() ];\r
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
-            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );\r
-            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );\r
-            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );\r
-        }\r
-        if ( getConfiguration().isEditable() ) {\r
-            _file_jmenu.addSeparator();\r
-            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );\r
-            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );\r
-        }\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );\r
-        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );\r
-        _save_all_item.setToolTipText( "Write all phylogenies to one file." );\r
-        _save_all_item.setEnabled( false );\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );\r
-        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" ) || AptxUtil.canWriteFormat( "TIF" ) ) {\r
-            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );\r
-        }\r
-        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );\r
-        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );\r
-        if ( AptxUtil.canWriteFormat( "gif" ) ) {\r
-            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );\r
-        }\r
-        if ( AptxUtil.canWriteFormat( "bmp" ) ) {\r
-            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );\r
+    private void collapse( final Phylogeny phy ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
+        double min_support = Double.MAX_VALUE;\r
+        boolean conf_present = false;\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                final List<Confidence> c = n.getBranchData().getConfidences();\r
+                if ( ( c != null ) && ( c.size() > 0 ) ) {\r
+                    conf_present = true;\r
+                    double max = 0;\r
+                    for( final Confidence confidence : c ) {\r
+                        if ( confidence.getValue() > max ) {\r
+                            max = confidence.getValue();\r
+                        }\r
+                    }\r
+                    if ( max < getMinNotCollapseConfidenceValue() ) {\r
+                        to_be_removed.add( n );\r
+                    }\r
+                    if ( max < min_support ) {\r
+                        min_support = max;\r
+                    }\r
+                }\r
+            }\r
         }\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );\r
-        _close_item.setToolTipText( "To close the current pane." );\r
-        _close_item.setEnabled( true );\r
-        _file_jmenu.addSeparator();\r
-        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );\r
-        customizeJMenuItem( _open_item );\r
-        _open_item\r
-                .setFont( new Font( _open_item.getFont().getFontName(), Font.BOLD, _open_item.getFont().getSize() + 4 ) );\r
-        customizeJMenuItem( _open_url_item );\r
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
-            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );\r
+        if ( conf_present ) {\r
+            for( final PhylogenyNode node : to_be_removed ) {\r
+                PhylogenyMethods.removeNode( node, phy );\r
+            }\r
+            if ( to_be_removed.size() > 0 ) {\r
+                phy.externalNodesHaveChanged();\r
+                phy.clearHashIdToNodeMap();\r
+                phy.recalculateNumberOfExternalDescendants( true );\r
+                getCurrentTreePanel().resetNodeIdToDistToLeafMap();\r
+                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();\r
+                getCurrentTreePanel().calculateLongestExtNodeInfo();\r
+                getCurrentTreePanel().setNodeInPreorderToNull();\r
+                getCurrentTreePanel().recalculateMaxDistanceToRoot();\r
+                getCurrentTreePanel().resetPreferredSize();\r
+                getCurrentTreePanel().setEdited( true );\r
+                getCurrentTreePanel().repaint();\r
+                repaint();\r
+            }\r
+            if ( to_be_removed.size() > 0 ) {\r
+                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
+                                               + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "\r
+                                                       + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "\r
+                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
         }\r
-        customizeJMenuItem( _save_item );\r
-        if ( getConfiguration().isEditable() ) {\r
-            customizeJMenuItem( _new_item );\r
+        else {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "No branch collapsed because no confidence values present",\r
+                                           "No confidence values present",\r
+                                           JOptionPane.INFORMATION_MESSAGE );\r
         }\r
-        customizeJMenuItem( _close_item );\r
-        customizeJMenuItem( _save_all_item );\r
-        customizeJMenuItem( _write_to_pdf_item );\r
-        customizeJMenuItem( _write_to_png_item );\r
-        customizeJMenuItem( _write_to_jpg_item );\r
-        customizeJMenuItem( _write_to_gif_item );\r
-        customizeJMenuItem( _write_to_tif_item );\r
-        customizeJMenuItem( _write_to_bmp_item );\r
-        customizeJMenuItem( _print_item );\r
-        customizeJMenuItem( _exit_item );\r
-        _jmenubar.add( _file_jmenu );\r
     }\r
 \r
-    void buildOptionsMenu() {\r
-        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );\r
-        _options_jmenu.addChangeListener( new ChangeListener() {\r
+    private void collapseBelowBranchLengthThreshold() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final String s = ( String ) JOptionPane\r
+                        .showInputDialog( this,\r
+                                          "Please enter the minimum branch length value\n",\r
+                                          "Minimal Branch Length Value",\r
+                                          JOptionPane.QUESTION_MESSAGE,\r
+                                          null,\r
+                                          null,\r
+                                          getMinNotCollapseBlValue() );\r
+                if ( !ForesterUtil.isEmpty( s ) ) {\r
+                    boolean success = true;\r
+                    double m = 0.0;\r
+                    final String m_str = s.trim();\r
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                        try {\r
+                            m = Double.parseDouble( m_str );\r
+                        }\r
+                        catch ( final Exception ex ) {\r
+                            success = false;\r
+                        }\r
+                    }\r
+                    else {\r
+                        success = false;\r
+                    }\r
+                    if ( success && ( m >= 0.0 ) ) {\r
+                        setMinNotCollapseBlValue( m );\r
+                        collapseBl( phy );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+    }\r
 \r
-            @Override\r
-            public void stateChanged( final ChangeEvent e ) {\r
-                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );\r
-                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );\r
-                MainFrame\r
-                        .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );\r
-                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame\r
-                        .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );\r
-                MainFrame.setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );\r
-                MainFrame.setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );\r
-                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );\r
-                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );\r
-                MainFrame.setCycleDataReturnMenuItem( _cycle_data_return, getOptions() );\r
-                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );\r
-                try {\r
-                    getMainPanel().getControlPanel().setVisibilityOfDomainStrucureCB();\r
-                    getMainPanel().getControlPanel().setVisibilityOfX();\r
+    private void collapseBelowThreshold() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final String s = ( String ) JOptionPane.showInputDialog( this,\r
+                                                                         "Please enter the minimum confidence value\n",\r
+                                                                         "Minimal Confidence Value",\r
+                                                                         JOptionPane.QUESTION_MESSAGE,\r
+                                                                         null,\r
+                                                                         null,\r
+                                                                         getMinNotCollapseConfidenceValue() );\r
+                if ( !ForesterUtil.isEmpty( s ) ) {\r
+                    boolean success = true;\r
+                    double m = 0.0;\r
+                    final String m_str = s.trim();\r
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                        try {\r
+                            m = Double.parseDouble( m_str );\r
+                        }\r
+                        catch ( final Exception ex ) {\r
+                            success = false;\r
+                        }\r
+                    }\r
+                    else {\r
+                        success = false;\r
+                    }\r
+                    if ( success && ( m >= 0.0 ) ) {\r
+                        setMinNotCollapseConfidenceValue( m );\r
+                        collapse( phy );\r
+                    }\r
                 }\r
-                catch ( final Exception ignore ) {\r
-                    // do nothing, not important.\r
+            }\r
+        }\r
+    }\r
+\r
+    private void collapseBl( final Phylogeny phy ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
+        double min_bl = Double.MAX_VALUE;\r
+        boolean bl_present = false;\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                final double bl = n.getDistanceToParent();\r
+                if ( bl != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {\r
+                    bl_present = true;\r
+                    if ( bl < getMinNotCollapseBlValue() ) {\r
+                        to_be_removed.add( n );\r
+                    }\r
+                    if ( bl < min_bl ) {\r
+                        min_bl = bl;\r
+                    }\r
                 }\r
             }\r
-        } );\r
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );\r
-        _options_jmenu\r
-                .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );\r
-        _options_jmenu.add( _uniform_cladograms_rbmi = new JRadioButtonMenuItem( MainFrame.UNIFORM_CLADOGRAMS_LABEL ) );\r
-        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );\r
-        _radio_group_1 = new ButtonGroup();\r
-        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );\r
-        _radio_group_1.add( _uniform_cladograms_rbmi );\r
-        _radio_group_1.add( _non_lined_up_cladograms_rbmi );\r
-        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );\r
-        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );\r
-        _options_jmenu\r
-                .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );\r
-        _options_jmenu\r
-                .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );\r
-        _options_jmenu\r
-                .add( _show_default_node_shapes_for_marked_cbmi = new JCheckBoxMenuItem( MainFrame.DISPLAY_NODE_BOXES_LABEL_MARKED ) );\r
-        _options_jmenu.add( _line_up_renderable_data_cbmi = new JCheckBoxMenuItem( MainFrame.LINE_UP_RENDERABLE_DATA ) );\r
-        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {\r
-            _options_jmenu.add( _right_line_up_domains_cbmi = new JCheckBoxMenuItem( MainFrame.RIGHT_LINE_UP_DOMAINS ) );\r
-            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( MainFrame.SHOW_DOMAIN_LABELS_LABEL ) );\r
         }\r
-        _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );\r
-        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );\r
-        _options_jmenu.add( _color_by_taxonomic_group_cbmi = new JCheckBoxMenuItem( COLOR_BY_TAXONOMIC_GROUP ) );\r
-        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );\r
-        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );\r
-        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );\r
-        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );\r
-        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );\r
-        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );\r
-        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );\r
-        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );\r
-        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );\r
-        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );\r
-        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.addSeparator();\r
-        _options_jmenu.add( _cycle_data_return = new JMenuItem( "Cycle Data Return" ) );\r
-        _options_jmenu.addSeparator();\r
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );\r
-        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );\r
-        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );\r
-        _options_jmenu.add( _search_with_regex_cbmi = new JCheckBoxMenuItem( MainFrame.SEARCH_REGEX_LABEL ) );\r
-        _search_with_regex_cbmi.setToolTipText( MainFrame.SEARCH_WITH_REGEX_TIP );\r
-        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );\r
-        _options_jmenu.addSeparator();\r
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),\r
-                                                      getConfiguration() ) );\r
-        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );\r
-        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );\r
-        _options_jmenu\r
-                .add( _print_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PDF export and Printing" ) );\r
-        _options_jmenu\r
-                .add( _graphics_export_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PNG, JPG, and GIF export" ) );\r
-        _options_jmenu\r
-                .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );\r
-        _options_jmenu.add( _print_size_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );\r
-        _options_jmenu.addSeparator();\r
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Input:" ), getConfiguration() ) );\r
-        _options_jmenu\r
-                .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );\r
-        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );\r
-        _options_jmenu\r
-                .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );\r
-        _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );\r
-        _options_jmenu\r
-                .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );\r
-        _options_jmenu\r
-                .add( _extract_taxonomy_pfam_relaxed_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style like Node Names" ) );\r
-        _options_jmenu\r
-                .add( _extract_taxonomy_agressive_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids/Scientific Names from Node Names" ) );\r
-        _extract_taxonomy_pfam_strict_rbmi\r
-                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"BCL2_MOUSE/123-304\" or \"BCL2_10090/123-304\"" );\r
-        _extract_taxonomy_pfam_relaxed_rbmi\r
-                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"bax_MOUSE\" or \"bax_10090\"" );\r
-        _extract_taxonomy_agressive_rbmi\r
-                .setToolTipText( "To extract taxonomy codes/ids or scientific names from node names in the form of e.g. \"MOUSE\" or \"10090\" or \"xyz_Nematostella_vectensis\"" );\r
-        _radio_group_2 = new ButtonGroup();\r
-        _radio_group_2.add( _extract_taxonomy_no_rbmi );\r
-        _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );\r
-        _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );\r
-        _radio_group_2.add( _extract_taxonomy_agressive_rbmi );\r
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );\r
-        _options_jmenu\r
-                .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );\r
-        _use_brackets_for_conf_in_nh_export_cbmi\r
-                .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );\r
-        _options_jmenu\r
-                .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );\r
-        customizeJMenuItem( _choose_font_mi );\r
-        customizeJMenuItem( _choose_minimal_confidence_mi );\r
-        customizeJMenuItem( _switch_colors_mi );\r
-        customizeJMenuItem( _print_size_mi );\r
-        customizeJMenuItem( _choose_pdf_width_mi );\r
-        customizeJMenuItem( _overview_placment_mi );\r
-        customizeCheckBoxMenuItem( _show_default_node_shapes_external_cbmi, getOptions()\r
-                .isShowDefaultNodeShapesExternal() );\r
-        customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi, getOptions()\r
-                .isShowDefaultNodeShapesInternal() );\r
-        customizeCheckBoxMenuItem( _show_default_node_shapes_for_marked_cbmi, getOptions()\r
-                .isShowDefaultNodeShapesForMarkedNodes() );\r
-        customizeJMenuItem( _cycle_node_shape_mi );\r
-        customizeJMenuItem( _cycle_node_fill_mi );\r
-        customizeJMenuItem( _choose_node_size_mi );\r
-        customizeJMenuItem( _cycle_data_return );\r
-        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );\r
-        customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );\r
-        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );\r
-        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );\r
-        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );\r
-        customizeCheckBoxMenuItem( _show_annotation_ref_source, getOptions().isShowAnnotationRefSource() );\r
-        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );\r
-        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );\r
-        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );\r
-        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,\r
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );\r
-        customizeRadioButtonMenuItem( _uniform_cladograms_rbmi,\r
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );\r
-        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,\r
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );\r
-        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );\r
-        customizeCheckBoxMenuItem( _label_direction_cbmi,\r
-                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );\r
-        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );\r
-        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );\r
-        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi, getOptions()\r
-                .isInternalNumberAreConfidenceForNhParsing() );\r
-        customizeRadioButtonMenuItem( _extract_taxonomy_no_rbmi,\r
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.NO );\r
-        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_strict_rbmi,\r
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );\r
-        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_relaxed_rbmi,\r
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );\r
-        customizeRadioButtonMenuItem( _extract_taxonomy_agressive_rbmi,\r
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.AGGRESSIVE );\r
-        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );\r
-        customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi, getOptions()\r
-                .isReplaceUnderscoresInNhParsing() );\r
-        customizeCheckBoxMenuItem( _search_with_regex_cbmi, getOptions().isSearchWithRegex() );\r
-        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );\r
-        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );\r
-        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );\r
-        customizeCheckBoxMenuItem( _print_using_actual_size_cbmi, getOptions().isPrintUsingActualSize() );\r
-        customizeCheckBoxMenuItem( _graphics_export_using_actual_size_cbmi, getOptions()\r
-                .isGraphicsExportUsingActualSize() );\r
-        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );\r
-        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi, getOptions()\r
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );\r
-        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()\r
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );\r
-        customizeCheckBoxMenuItem( _line_up_renderable_data_cbmi, getOptions().isLineUpRendarableNodeData() );\r
-        customizeCheckBoxMenuItem( _right_line_up_domains_cbmi, getOptions().isRightLineUpDomains() );\r
-        _jmenubar.add( _options_jmenu );\r
-    }\r
-\r
-    void buildPhylogeneticInferenceMenu() {\r
-        final InferenceManager im = getInferenceManager();\r
-        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );\r
-        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );\r
-        customizeJMenuItem( _inference_from_msa_item );\r
-        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );\r
-        if ( im.canDoMsa() ) {\r
-            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );\r
-            customizeJMenuItem( _inference_from_seqs_item );\r
-            _inference_from_seqs_item\r
-                    .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );\r
-        }\r
-        else {\r
-            _inference_menu\r
-                    .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );\r
-            customizeJMenuItem( _inference_from_seqs_item );\r
-            _inference_from_seqs_item.setEnabled( false );\r
-        }\r
-        _jmenubar.add( _inference_menu );\r
-    }\r
-\r
-    void buildToolsMenu() {\r
-        _tools_menu = createMenu( "Tools", getConfiguration() );\r
-        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );\r
-        customizeJMenuItem( _confcolor_item );\r
-        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );\r
-        customizeJMenuItem( _color_rank_jmi );\r
-        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );\r
-        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );\r
-        customizeJMenuItem( _taxcolor_item );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _remove_visual_styles_item = new JMenuItem( "Delete All Visual Styles From Nodes" ) );\r
-        _remove_visual_styles_item\r
-                .setToolTipText( "To remove all node visual styles (fonts, colors) from the current phylogeny" );\r
-        customizeJMenuItem( _remove_visual_styles_item );\r
-        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete All Colors From Branches" ) );\r
-        _remove_branch_color_item.setToolTipText( "To remove all branch color values from the current phylogeny" );\r
-        customizeJMenuItem( _remove_branch_color_item );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );\r
-        customizeJMenuItem( _annotate_item );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );\r
-        customizeJMenuItem( _midpoint_root_item );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _delete_selected_nodes_item = new JMenuItem( "Delete Selected Nodes" ) );\r
-        _delete_selected_nodes_item.setToolTipText( "To delete all selected external nodes" );\r
-        customizeJMenuItem( _delete_selected_nodes_item );\r
-        _tools_menu.add( _delete_not_selected_nodes_item = new JMenuItem( "Retain Selected Nodes" ) );\r
-        _delete_not_selected_nodes_item.setToolTipText( "To delete all not selected external nodes" );\r
-        customizeJMenuItem( _delete_not_selected_nodes_item );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );\r
-        customizeJMenuItem( _collapse_species_specific_subtrees );\r
-        _collapse_species_specific_subtrees.setToolTipText( "To (reversibly) collapse species-specific subtrees" );\r
-        _tools_menu\r
-                .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );\r
-        customizeJMenuItem( _collapse_below_threshold );\r
-        _collapse_below_threshold\r
-                .setToolTipText( "To (permanently) collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );\r
-        //\r
-        _tools_menu\r
-                .add( _collapse_below_branch_length = new JMenuItem( "Collapse Branches with Branch Lengths Below Threshold into Multifurcations" ) );\r
-        customizeJMenuItem( _collapse_below_branch_length );\r
-        _collapse_below_branch_length\r
-                .setToolTipText( "To (permanently) collapse branches with branches with branch lengths below a threshold into multifurcations" );\r
-        //\r
-        _tools_menu.addSeparator();\r
-        _tools_menu\r
-                .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );\r
-        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );\r
-        _extract_tax_code_from_node_names_jmi\r
-                .setToolTipText( "To extract SwissProt/Uniprot taxonomic codes (mnemonics) from nodes names in the form of 'xyz_CAEEL', Uniprot/NCBI identifiers form of 'xyz_6239', or scientific names form of 'xyz_Caenorhabditis_elegans'" );\r
-        _tools_menu\r
-                .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );\r
-        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );\r
-        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );\r
-        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );\r
-        customizeJMenuItem( _move_node_names_to_seq_names_jmi );\r
-        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );\r
-        customizeJMenuItem( _obtain_seq_information_jmi );\r
-        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );\r
-        _tools_menu\r
-                .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );\r
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );\r
-        _obtain_detailed_taxonomic_information_jmi\r
-                .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );\r
-        _tools_menu\r
-                .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );\r
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );\r
-        _obtain_detailed_taxonomic_information_deleting_jmi\r
-                .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );\r
-        _tools_menu.addSeparator();\r
-        _tools_menu.add( _read_values_jmi = new JMenuItem( "Attach Vector/Expression Values" ) );\r
-        customizeJMenuItem( _read_values_jmi );\r
-        _read_values_jmi.setToolTipText( "To attach vector (e.g. gene expression) values to tree nodes (beta)" );\r
-        _jmenubar.add( _tools_menu );\r
-        _tools_menu.add( _read_seqs_jmi = new JMenuItem( "Attach Molecular Sequences" ) );\r
-        customizeJMenuItem( _read_seqs_jmi );\r
-        _read_seqs_jmi\r
-                .setToolTipText( "To attach molecular sequences to tree nodes (from Fasta-formatted file) (beta)" );\r
-        _jmenubar.add( _tools_menu );\r
-    }\r
-\r
-    @Override\r
-    void close() {\r
-        if ( isUnsavedDataPresent() ) {\r
-            final int r = JOptionPane.showConfirmDialog( this,\r
-                                                         "Exit despite potentially unsaved changes?",\r
-                                                         "Exit?",\r
-                                                         JOptionPane.YES_NO_OPTION );\r
-            if ( r != JOptionPane.YES_OPTION ) {\r
-                return;\r
-            }\r
-        }\r
-        exit();\r
-    }\r
-\r
-    private void closeCurrentPane() {\r
-        if ( getMainPanel().getCurrentTreePanel() != null ) {\r
-            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {\r
-                final int r = JOptionPane.showConfirmDialog( this,\r
-                                                             "Close tab despite potentially unsaved changes?",\r
-                                                             "Close Tab?",\r
-                                                             JOptionPane.YES_NO_OPTION );\r
-                if ( r != JOptionPane.YES_OPTION ) {\r
-                    return;\r
-                }\r
-            }\r
-            getMainPanel().closeCurrentPane();\r
-            activateSaveAllIfNeeded();\r
-        }\r
-    }\r
-\r
-    private void collapse( final Phylogeny phy ) {\r
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
-        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
-        double min_support = Double.MAX_VALUE;\r
-        boolean conf_present = false;\r
-        while ( it.hasNext() ) {\r
-            final PhylogenyNode n = it.next();\r
-            if ( !n.isExternal() && !n.isRoot() ) {\r
-                final List<Confidence> c = n.getBranchData().getConfidences();\r
-                if ( ( c != null ) && ( c.size() > 0 ) ) {\r
-                    conf_present = true;\r
-                    double max = 0;\r
-                    for( final Confidence confidence : c ) {\r
-                        if ( confidence.getValue() > max ) {\r
-                            max = confidence.getValue();\r
-                        }\r
-                    }\r
-                    if ( max < getMinNotCollapseConfidenceValue() ) {\r
-                        to_be_removed.add( n );\r
-                    }\r
-                    if ( max < min_support ) {\r
-                        min_support = max;\r
-                    }\r
-                }\r
-            }\r
-        }\r
-        if ( conf_present ) {\r
+        if ( bl_present ) {\r
             for( final PhylogenyNode node : to_be_removed ) {\r
                 PhylogenyMethods.removeNode( node, phy );\r
             }\r
@@ -1263,147 +1165,20 @@ public final class MainFrameApplication extends MainFrame {
             }\r
             if ( to_be_removed.size() > 0 ) {\r
                 JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
-                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "\r
-                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
+                                               + " branches with\nbranch length values below " + getMinNotCollapseBlValue(), "Collapsed "\r
+                                                       + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
             }\r
             else {\r
-                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "\r
-                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "No branch collapsed,\nminimum branch length is " + min_bl,\r
+                                               "No branch collapsed",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
             }\r
         }\r
         else {\r
             JOptionPane.showMessageDialog( this,\r
-                                           "No branch collapsed because no confidence values present",\r
-                                           "No confidence values present",\r
-                                           JOptionPane.INFORMATION_MESSAGE );\r
-        }\r
-    }\r
-\r
-    private void collapseBelowBranchLengthThreshold() {\r
-        if ( getCurrentTreePanel() != null ) {\r
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
-            if ( ( phy != null ) && !phy.isEmpty() ) {\r
-                final String s = ( String ) JOptionPane\r
-                        .showInputDialog( this,\r
-                                          "Please enter the minimum branch length value\n",\r
-                                          "Minimal Branch Length Value",\r
-                                          JOptionPane.QUESTION_MESSAGE,\r
-                                          null,\r
-                                          null,\r
-                                          getMinNotCollapseBlValue() );\r
-                if ( !ForesterUtil.isEmpty( s ) ) {\r
-                    boolean success = true;\r
-                    double m = 0.0;\r
-                    final String m_str = s.trim();\r
-                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
-                        try {\r
-                            m = Double.parseDouble( m_str );\r
-                        }\r
-                        catch ( final Exception ex ) {\r
-                            success = false;\r
-                        }\r
-                    }\r
-                    else {\r
-                        success = false;\r
-                    }\r
-                    if ( success && ( m >= 0.0 ) ) {\r
-                        setMinNotCollapseBlValue( m );\r
-                        collapseBl( phy );\r
-                    }\r
-                }\r
-            }\r
-        }\r
-    }\r
-\r
-    private void collapseBelowThreshold() {\r
-        if ( getCurrentTreePanel() != null ) {\r
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
-            if ( ( phy != null ) && !phy.isEmpty() ) {\r
-                final String s = ( String ) JOptionPane.showInputDialog( this,\r
-                                                                         "Please enter the minimum confidence value\n",\r
-                                                                         "Minimal Confidence Value",\r
-                                                                         JOptionPane.QUESTION_MESSAGE,\r
-                                                                         null,\r
-                                                                         null,\r
-                                                                         getMinNotCollapseConfidenceValue() );\r
-                if ( !ForesterUtil.isEmpty( s ) ) {\r
-                    boolean success = true;\r
-                    double m = 0.0;\r
-                    final String m_str = s.trim();\r
-                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
-                        try {\r
-                            m = Double.parseDouble( m_str );\r
-                        }\r
-                        catch ( final Exception ex ) {\r
-                            success = false;\r
-                        }\r
-                    }\r
-                    else {\r
-                        success = false;\r
-                    }\r
-                    if ( success && ( m >= 0.0 ) ) {\r
-                        setMinNotCollapseConfidenceValue( m );\r
-                        collapse( phy );\r
-                    }\r
-                }\r
-            }\r
-        }\r
-    }\r
-\r
-    private void collapseBl( final Phylogeny phy ) {\r
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
-        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
-        double min_bl = Double.MAX_VALUE;\r
-        boolean bl_present = false;\r
-        while ( it.hasNext() ) {\r
-            final PhylogenyNode n = it.next();\r
-            if ( !n.isExternal() && !n.isRoot() ) {\r
-                final double bl = n.getDistanceToParent();\r
-                if ( bl != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {\r
-                    bl_present = true;\r
-                    if ( bl < getMinNotCollapseBlValue() ) {\r
-                        to_be_removed.add( n );\r
-                    }\r
-                    if ( bl < min_bl ) {\r
-                        min_bl = bl;\r
-                    }\r
-                }\r
-            }\r
-        }\r
-        if ( bl_present ) {\r
-            for( final PhylogenyNode node : to_be_removed ) {\r
-                PhylogenyMethods.removeNode( node, phy );\r
-            }\r
-            if ( to_be_removed.size() > 0 ) {\r
-                phy.externalNodesHaveChanged();\r
-                phy.clearHashIdToNodeMap();\r
-                phy.recalculateNumberOfExternalDescendants( true );\r
-                getCurrentTreePanel().resetNodeIdToDistToLeafMap();\r
-                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();\r
-                getCurrentTreePanel().calculateLongestExtNodeInfo();\r
-                getCurrentTreePanel().setNodeInPreorderToNull();\r
-                getCurrentTreePanel().recalculateMaxDistanceToRoot();\r
-                getCurrentTreePanel().resetPreferredSize();\r
-                getCurrentTreePanel().setEdited( true );\r
-                getCurrentTreePanel().repaint();\r
-                repaint();\r
-            }\r
-            if ( to_be_removed.size() > 0 ) {\r
-                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
-                        + " branches with\nbranch length values below " + getMinNotCollapseBlValue(), "Collapsed "\r
-                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
-            }\r
-            else {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "No branch collapsed,\nminimum branch length is " + min_bl,\r
-                                               "No branch collapsed",\r
-                                               JOptionPane.INFORMATION_MESSAGE );\r
-            }\r
-        }\r
-        else {\r
-            JOptionPane.showMessageDialog( this,\r
-                                           "No branch collapsed because no branch length values present",\r
-                                           "No branch length values present",\r
+                                           "No branch collapsed because no branch length values present",\r
+                                           "No branch length values present",\r
                                            JOptionPane.INFORMATION_MESSAGE );\r
         }\r
     }\r
@@ -1427,31 +1202,6 @@ public final class MainFrameApplication extends MainFrame {
         return xml_parser;\r
     }\r
 \r
-    public void end() {\r
-        _mainpanel.terminate();\r
-        _contentpane.removeAll();\r
-        setVisible( false );\r
-        dispose();\r
-    }\r
-\r
-    void executeLineageInference() {\r
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {\r
-            return;\r
-        }\r
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
-            JOptionPane.showMessageDialog( this,\r
-                                           "Phylogeny is not rooted.",\r
-                                           "Cannot infer ancestral taxonomies",\r
-                                           JOptionPane.ERROR_MESSAGE );\r
-            return;\r
-        }\r
-        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,\r
-                                                                                  _mainpanel.getCurrentTreePanel(),\r
-                                                                                  _mainpanel.getCurrentPhylogeny()\r
-                                                                                          .copy() );\r
-        new Thread( inferrer ).start();\r
-    }\r
-\r
     private void executePhyleneticInference( final boolean from_unaligned_seqs ) {\r
         final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,\r
                                                                       getPhylogeneticInferenceOptions(),\r
@@ -1462,7 +1212,7 @@ public final class MainFrameApplication extends MainFrame {
                 if ( getMsa() != null ) {\r
                     final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getMsa(),\r
                                                                                     getPhylogeneticInferenceOptions()\r
-                                                                                            .copy(), this );\r
+                                                                                    .copy(), this );\r
                     new Thread( inferrer ).start();\r
                 }\r
                 else {\r
@@ -1476,7 +1226,7 @@ public final class MainFrameApplication extends MainFrame {
                 if ( getSeqs() != null ) {\r
                     final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getSeqs(),\r
                                                                                     getPhylogeneticInferenceOptions()\r
-                                                                                            .copy(), this );\r
+                                                                                    .copy(), this );\r
                     new Thread( inferrer ).start();\r
                 }\r
                 else {\r
@@ -1489,15 +1239,6 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    void exit() {\r
-        removeAllTextFrames();\r
-        _mainpanel.terminate();\r
-        _contentpane.removeAll();\r
-        setVisible( false );\r
-        dispose();\r
-        // System.exit( 0 ); //TODO reconfirm that this is OK, then remove.\r
-    }\r
-\r
     private void extractTaxDataFromNodeNames() throws PhyloXmlDataFormatException {\r
         final StringBuilder sb = new StringBuilder();\r
         final StringBuilder sb_failed = new StringBuilder();\r
@@ -1543,17 +1284,17 @@ public final class MainFrameApplication extends MainFrame {
                     }\r
                     JOptionPane.showMessageDialog( this,\r
                                                    "Extracted taxonomic data from " + all + counter\r
-                                                           + " named external nodes:\n" + sb.toString() + failed,\r
+                                                   + " named external nodes:\n" + sb.toString() + failed,\r
                                                    "Taxonomic Data Extraction Completed",\r
                                                    counter_failed > 0 ? JOptionPane.WARNING_MESSAGE\r
                                                            : JOptionPane.INFORMATION_MESSAGE );\r
                 }\r
                 else {\r
                     JOptionPane\r
-                            .showMessageDialog( this,\r
-                                                "Could not extract any taxonomic data.\nMaybe node names are empty\n"\r
-                                                        + "or not in the forms \"XYZ_CAEEL\", \"XYZ_6239\", or \"XYZ_Caenorhabditis_elegans\"\n"\r
-                                                        + "or nodes already have taxonomic data?\n",\r
+                    .showMessageDialog( this,\r
+                                        "Could not extract any taxonomic data.\nMaybe node names are empty\n"\r
+                                                + "or not in the forms \"XYZ_CAEEL\", \"XYZ_6239\", or \"XYZ_Caenorhabditis_elegans\"\n"\r
+                                                + "or nodes already have taxonomic data?\n",\r
                                                 "No Taxonomic Data Extracted",\r
                                                 JOptionPane.ERROR_MESSAGE );\r
                 }\r
@@ -1561,11 +1302,6 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-    @Override\r
-    public MainPanel getMainPanel() {\r
-        return _mainpanel;\r
-    }\r
-\r
     private double getMinNotCollapseBlValue() {\r
         return _min_not_collapse_bl;\r
     }\r
@@ -1574,14 +1310,6 @@ public final class MainFrameApplication extends MainFrame {
         return _min_not_collapse;\r
     }\r
 \r
-    public Msa getMsa() {\r
-        return _msa;\r
-    }\r
-\r
-    public File getMsaFile() {\r
-        return _msa_file;\r
-    }\r
-\r
     private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {\r
         if ( _phylogenetic_inference_options == null ) {\r
             _phylogenetic_inference_options = new PhylogeneticInferenceOptions();\r
@@ -1589,14 +1317,6 @@ public final class MainFrameApplication extends MainFrame {
         return _phylogenetic_inference_options;\r
     }\r
 \r
-    public List<MolecularSequence> getSeqs() {\r
-        return _seqs;\r
-    }\r
-\r
-    public File getSeqsFile() {\r
-        return _seqs_file;\r
-    }\r
-\r
     private boolean isUnsavedDataPresent() {\r
         final List<TreePanel> tps = getMainPanel().getTreePanels();\r
         for( final TreePanel tp : tps ) {\r
@@ -1612,7 +1332,7 @@ public final class MainFrameApplication extends MainFrame {
             final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
             if ( ( phy != null ) && !phy.isEmpty() ) {\r
                 PhylogenyMethods\r
-                        .transferNodeNameToField( phy, PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME, false );\r
+                .transferNodeNameToField( phy, PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME, false );\r
             }\r
         }\r
     }\r
@@ -1642,7 +1362,7 @@ public final class MainFrameApplication extends MainFrame {
         if ( getMainPanel().getMainFrame() == null ) {\r
             // Must be "E" applet version.\r
             ( ( ArchaeopteryxE ) ( ( MainPanelApplets ) getMainPanel() ).getApplet() )\r
-                    .setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+            .setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
         }\r
         else {\r
             getMainPanel().getMainFrame().setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
@@ -1715,102 +1435,15 @@ public final class MainFrameApplication extends MainFrame {
         }\r
     }\r
 \r
-   \r
-\r
-    public void readMsaFromFile() {\r
+    private void readPhylogeniesFromFile() {\r
+        boolean exception = false;\r
+        Phylogeny[] phys = null;\r
         // Set an initial directory if none set yet\r
         final File my_dir = getCurrentDir();\r
-        _msa_filechooser.setMultiSelectionEnabled( false );\r
+        _open_filechooser.setMultiSelectionEnabled( true );\r
         // Open file-open dialog and set current directory\r
         if ( my_dir != null ) {\r
-            _msa_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _msa_filechooser.showOpenDialog( _contentpane );\r
-        // All done: get the msa\r
-        final File file = _msa_filechooser.getSelectedFile();\r
-        setCurrentDir( _msa_filechooser.getCurrentDirectory() );\r
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            setMsaFile( null );\r
-            setMsa( null );\r
-            Msa msa = null;\r
-            try {\r
-                final InputStream is = new FileInputStream( file );\r
-                if ( FastaParser.isLikelyFasta( file ) ) {\r
-                    msa = FastaParser.parseMsa( is );\r
-                }\r
-                else {\r
-                    msa = GeneralMsaParser.parse( is );\r
-                }\r
-            }\r
-            catch ( final MsaFormatException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Multiple sequence alignment format error",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final IOException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Failed to read multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final IllegalArgumentException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final Exception e ) {\r
-                setArrowCursor();\r
-                e.printStackTrace();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment is empty",\r
-                                               "Illegal Multiple Sequence Alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( msa.getNumberOfSequences() < 4 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment needs to contain at least 3 sequences",\r
-                                               "Illegal multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( msa.getLength() < 2 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence alignment needs to contain at least 2 residues",\r
-                                               "Illegal multiple sequence alignment",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            System.gc();\r
-            setMsaFile( _msa_filechooser.getSelectedFile() );\r
-            setMsa( msa );\r
-        }\r
-    }\r
-\r
-    private void readPhylogeniesFromFile() {\r
-        boolean exception = false;\r
-        Phylogeny[] phys = null;\r
-        // Set an initial directory if none set yet\r
-        final File my_dir = getCurrentDir();\r
-        _open_filechooser.setMultiSelectionEnabled( true );\r
-        // Open file-open dialog and set current directory\r
-        if ( my_dir != null ) {\r
-            _open_filechooser.setCurrentDirectory( my_dir );\r
+            _open_filechooser.setCurrentDirectory( my_dir );\r
         }\r
         final int result = _open_filechooser.showOpenDialog( _contentpane );\r
         // All done: get the file\r
@@ -1876,7 +1509,7 @@ public final class MainFrameApplication extends MainFrame {
                         try {\r
                             final PhylogenyParser parser = ParserUtils\r
                                     .createParserDependingOnFileType( file, getConfiguration()\r
-                                            .isValidatePhyloXmlAgainstSchema() );\r
+                                                                      .isValidatePhyloXmlAgainstSchema() );\r
                             if ( parser instanceof NexusPhylogeniesParser ) {\r
                                 final NexusPhylogeniesParser nex = ( NexusPhylogeniesParser ) parser;\r
                                 setSpecialOptionsForNexParser( nex );\r
@@ -1927,10 +1560,10 @@ public final class MainFrameApplication extends MainFrame {
                         _mainpanel.getControlPanel().showWhole();\r
                         if ( nhx_or_nexus && one_desc ) {\r
                             JOptionPane\r
-                                    .showMessageDialog( this,\r
-                                                        "One or more trees contain (a) node(s) with one descendant, "\r
-                                                                + ForesterUtil.LINE_SEPARATOR\r
-                                                                + "possibly indicating illegal parentheses within node names.",\r
+                            .showMessageDialog( this,\r
+                                                "One or more trees contain (a) node(s) with one descendant, "\r
+                                                        + ForesterUtil.LINE_SEPARATOR\r
+                                                        + "possibly indicating illegal parentheses within node names.",\r
                                                         "Warning: Possible Error in New Hampshire Formatted Data",\r
                                                         JOptionPane.WARNING_MESSAGE );\r
                         }\r
@@ -1938,8 +1571,554 @@ public final class MainFrameApplication extends MainFrame {
                 }\r
             }\r
         }\r
-        activateSaveAllIfNeeded();\r
-        System.gc();\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    private void readSpeciesTreeFromFile() {\r
+        Phylogeny t = null;\r
+        boolean exception = false;\r
+        final File my_dir = getCurrentDir();\r
+        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );\r
+        if ( my_dir != null ) {\r
+            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );\r
+        final File file = _open_filechooser_for_species_tree.getSelectedFile();\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.xmlfilter ) {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
+                                                                                .createPhyloXmlParserXsdValidating(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.tolfilter ) {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            // "*.*":\r
+            else {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
+                                                                                .createPhyloXmlParserXsdValidating(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            if ( !exception && ( t != null ) && !t.isRooted() ) {\r
+                exception = true;\r
+                t = null;\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Species tree is not rooted",\r
+                                               "Species tree not loaded",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            if ( !exception && ( t != null ) ) {\r
+                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();\r
+                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {\r
+                    final PhylogenyNode node = it.next();\r
+                    if ( !node.getNodeData().isHasTaxonomy() ) {\r
+                        exception = true;\r
+                        t = null;\r
+                        JOptionPane\r
+                        .showMessageDialog( this,\r
+                                            "Species tree contains external node(s) without taxonomy information",\r
+                                            "Species tree not loaded",\r
+                                            JOptionPane.ERROR_MESSAGE );\r
+                        break;\r
+                    }\r
+                    else {\r
+                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {\r
+                            exception = true;\r
+                            t = null;\r
+                            JOptionPane.showMessageDialog( this,\r
+                                                           "Taxonomy ["\r
+                                                                   + node.getNodeData().getTaxonomy().asSimpleText()\r
+                                                                   + "] is not unique in species tree",\r
+                                                                   "Species tree not loaded",\r
+                                                                   JOptionPane.ERROR_MESSAGE );\r
+                            break;\r
+                        }\r
+                        else {\r
+                            tax_set.add( node.getNodeData().getTaxonomy() );\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+            if ( !exception && ( t != null ) ) {\r
+                setSpeciesTree( t );\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Species tree successfully loaded",\r
+                                               "Species tree loaded",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            _contentpane.repaint();\r
+            System.gc();\r
+        }\r
+    }\r
+\r
+    private void setArrowCursor() {\r
+        try {\r
+            _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+        }\r
+        catch ( final Exception ex ) {\r
+            // Do nothing.\r
+        }\r
+    }\r
+\r
+    private void setMinNotCollapseBlValue( final double min_not_collapse_bl ) {\r
+        _min_not_collapse_bl = min_not_collapse_bl;\r
+    }\r
+\r
+    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {\r
+        _min_not_collapse = min_not_collapse;\r
+    }\r
+\r
+    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {\r
+        _phylogenetic_inference_options = phylogenetic_inference_options;\r
+    }\r
+\r
+    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {\r
+        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
+        nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
+    }\r
+\r
+    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {\r
+        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
+        nhx.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
+        nhx.setAllowErrorsInDistanceToParent( getOptions().isAllowErrorsInDistanceToParent() );\r
+    }\r
+\r
+    void buildAnalysisMenu() {\r
+        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );\r
+        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );\r
+        _analysis_menu.add( _gsdir_item = new JMenuItem( "GSDIR (GSDI with re-rooting)" ) );\r
+        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );\r
+        customizeJMenuItem( _gsdi_item );\r
+        customizeJMenuItem( _gsdir_item );\r
+        customizeJMenuItem( _load_species_tree_item );\r
+        _analysis_menu.addSeparator();\r
+        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );\r
+        customizeJMenuItem( _lineage_inference );\r
+        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );\r
+        _jmenubar.add( _analysis_menu );\r
+    }\r
+\r
+    @Override\r
+    void buildFileMenu() {\r
+        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );\r
+        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _open_url_item = new JMenuItem( "Read Tree from URL/Webservice..." ) );\r
+        _file_jmenu.addSeparator();\r
+        final WebservicesManager webservices_manager = WebservicesManager.getInstance();\r
+        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager\r
+                                                                    .getAvailablePhylogeniesWebserviceClients().size() ];\r
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
+            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );\r
+            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );\r
+            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );\r
+        }\r
+        if ( getConfiguration().isEditable() ) {\r
+            _file_jmenu.addSeparator();\r
+            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );\r
+            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );\r
+        }\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );\r
+        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );\r
+        _save_all_item.setToolTipText( "Write all phylogenies to one file." );\r
+        _save_all_item.setEnabled( false );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );\r
+        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" ) || AptxUtil.canWriteFormat( "TIF" ) ) {\r
+            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );\r
+        }\r
+        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );\r
+        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );\r
+        if ( AptxUtil.canWriteFormat( "gif" ) ) {\r
+            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );\r
+        }\r
+        if ( AptxUtil.canWriteFormat( "bmp" ) ) {\r
+            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );\r
+        }\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );\r
+        _close_item.setToolTipText( "To close the current pane." );\r
+        _close_item.setEnabled( true );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );\r
+        customizeJMenuItem( _open_item );\r
+        _open_item\r
+        .setFont( new Font( _open_item.getFont().getFontName(), Font.BOLD, _open_item.getFont().getSize() + 4 ) );\r
+        customizeJMenuItem( _open_url_item );\r
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
+            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );\r
+        }\r
+        customizeJMenuItem( _save_item );\r
+        if ( getConfiguration().isEditable() ) {\r
+            customizeJMenuItem( _new_item );\r
+        }\r
+        customizeJMenuItem( _close_item );\r
+        customizeJMenuItem( _save_all_item );\r
+        customizeJMenuItem( _write_to_pdf_item );\r
+        customizeJMenuItem( _write_to_png_item );\r
+        customizeJMenuItem( _write_to_jpg_item );\r
+        customizeJMenuItem( _write_to_gif_item );\r
+        customizeJMenuItem( _write_to_tif_item );\r
+        customizeJMenuItem( _write_to_bmp_item );\r
+        customizeJMenuItem( _print_item );\r
+        customizeJMenuItem( _exit_item );\r
+        _jmenubar.add( _file_jmenu );\r
+    }\r
+\r
+    void buildOptionsMenu() {\r
+        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );\r
+        _options_jmenu.addChangeListener( new ChangeListener() {\r
+\r
+            @Override\r
+            public void stateChanged( final ChangeEvent e ) {\r
+                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );\r
+                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );\r
+                MainFrame\r
+                .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );\r
+                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame\r
+                                                         .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );\r
+                MainFrame.setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );\r
+                MainFrame.setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );\r
+                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );\r
+                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );\r
+                MainFrame.setCycleDataReturnMenuItem( _cycle_data_return, getOptions() );\r
+                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );\r
+                try {\r
+                    getMainPanel().getControlPanel().setVisibilityOfDomainStrucureCB();\r
+                    getMainPanel().getControlPanel().setVisibilityOfX();\r
+                }\r
+                catch ( final Exception ignore ) {\r
+                    // do nothing, not important.\r
+                }\r
+            }\r
+        } );\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );\r
+        _options_jmenu\r
+        .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );\r
+        _options_jmenu.add( _uniform_cladograms_rbmi = new JRadioButtonMenuItem( MainFrame.UNIFORM_CLADOGRAMS_LABEL ) );\r
+        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );\r
+        _radio_group_1 = new ButtonGroup();\r
+        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );\r
+        _radio_group_1.add( _uniform_cladograms_rbmi );\r
+        _radio_group_1.add( _non_lined_up_cladograms_rbmi );\r
+        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );\r
+        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );\r
+        _options_jmenu\r
+        .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );\r
+        _options_jmenu\r
+        .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );\r
+        _options_jmenu\r
+        .add( _show_default_node_shapes_for_marked_cbmi = new JCheckBoxMenuItem( MainFrame.DISPLAY_NODE_BOXES_LABEL_MARKED ) );\r
+        _options_jmenu.add( _line_up_renderable_data_cbmi = new JCheckBoxMenuItem( MainFrame.LINE_UP_RENDERABLE_DATA ) );\r
+        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {\r
+            _options_jmenu.add( _right_line_up_domains_cbmi = new JCheckBoxMenuItem( MainFrame.RIGHT_LINE_UP_DOMAINS ) );\r
+            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( MainFrame.SHOW_DOMAIN_LABELS_LABEL ) );\r
+        }\r
+        _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );\r
+        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );\r
+        _options_jmenu.add( _color_by_taxonomic_group_cbmi = new JCheckBoxMenuItem( COLOR_BY_TAXONOMIC_GROUP ) );\r
+        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );\r
+        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );\r
+        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );\r
+        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );\r
+        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );\r
+        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );\r
+        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );\r
+        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );\r
+        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );\r
+        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );\r
+        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( _cycle_data_return = new JMenuItem( "Cycle Data Return" ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );\r
+        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );\r
+        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );\r
+        _options_jmenu.add( _search_with_regex_cbmi = new JCheckBoxMenuItem( MainFrame.SEARCH_REGEX_LABEL ) );\r
+        _search_with_regex_cbmi.setToolTipText( MainFrame.SEARCH_WITH_REGEX_TIP );\r
+        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),\r
+                                                      getConfiguration() ) );\r
+        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );\r
+        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );\r
+        _options_jmenu\r
+        .add( _print_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PDF export and Printing" ) );\r
+        _options_jmenu\r
+        .add( _graphics_export_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PNG, JPG, and GIF export" ) );\r
+        _options_jmenu\r
+        .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );\r
+        _options_jmenu.add( _print_size_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Input:" ), getConfiguration() ) );\r
+        _options_jmenu\r
+        .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );\r
+        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );\r
+        _options_jmenu\r
+        .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );\r
+        _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );\r
+        _options_jmenu\r
+        .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );\r
+        _options_jmenu\r
+        .add( _extract_taxonomy_pfam_relaxed_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style like Node Names" ) );\r
+        _options_jmenu\r
+        .add( _extract_taxonomy_agressive_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids/Scientific Names from Node Names" ) );\r
+        _extract_taxonomy_pfam_strict_rbmi\r
+        .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"BCL2_MOUSE/123-304\" or \"BCL2_10090/123-304\"" );\r
+        _extract_taxonomy_pfam_relaxed_rbmi\r
+        .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"bax_MOUSE\" or \"bax_10090\"" );\r
+        _extract_taxonomy_agressive_rbmi\r
+        .setToolTipText( "To extract taxonomy codes/ids or scientific names from node names in the form of e.g. \"MOUSE\" or \"10090\" or \"xyz_Nematostella_vectensis\"" );\r
+        _radio_group_2 = new ButtonGroup();\r
+        _radio_group_2.add( _extract_taxonomy_no_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_agressive_rbmi );\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );\r
+        _options_jmenu\r
+        .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );\r
+        _use_brackets_for_conf_in_nh_export_cbmi\r
+        .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );\r
+        _options_jmenu\r
+        .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );\r
+        customizeJMenuItem( _choose_font_mi );\r
+        customizeJMenuItem( _choose_minimal_confidence_mi );\r
+        customizeJMenuItem( _switch_colors_mi );\r
+        customizeJMenuItem( _print_size_mi );\r
+        customizeJMenuItem( _choose_pdf_width_mi );\r
+        customizeJMenuItem( _overview_placment_mi );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_external_cbmi, getOptions()\r
+                                   .isShowDefaultNodeShapesExternal() );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi, getOptions()\r
+                                   .isShowDefaultNodeShapesInternal() );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_for_marked_cbmi, getOptions()\r
+                                   .isShowDefaultNodeShapesForMarkedNodes() );\r
+        customizeJMenuItem( _cycle_node_shape_mi );\r
+        customizeJMenuItem( _cycle_node_fill_mi );\r
+        customizeJMenuItem( _choose_node_size_mi );\r
+        customizeJMenuItem( _cycle_data_return );\r
+        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );\r
+        customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );\r
+        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );\r
+        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );\r
+        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );\r
+        customizeCheckBoxMenuItem( _show_annotation_ref_source, getOptions().isShowAnnotationRefSource() );\r
+        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );\r
+        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );\r
+        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );\r
+        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );\r
+        customizeRadioButtonMenuItem( _uniform_cladograms_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );\r
+        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );\r
+        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );\r
+        customizeCheckBoxMenuItem( _label_direction_cbmi,\r
+                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );\r
+        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );\r
+        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );\r
+        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi, getOptions()\r
+                                   .isInternalNumberAreConfidenceForNhParsing() );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_no_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.NO );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_strict_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_relaxed_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_agressive_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.AGGRESSIVE );\r
+        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );\r
+        customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi, getOptions()\r
+                                   .isReplaceUnderscoresInNhParsing() );\r
+        customizeCheckBoxMenuItem( _search_with_regex_cbmi, getOptions().isSearchWithRegex() );\r
+        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );\r
+        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );\r
+        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );\r
+        customizeCheckBoxMenuItem( _print_using_actual_size_cbmi, getOptions().isPrintUsingActualSize() );\r
+        customizeCheckBoxMenuItem( _graphics_export_using_actual_size_cbmi, getOptions()\r
+                                   .isGraphicsExportUsingActualSize() );\r
+        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );\r
+        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi, getOptions()\r
+                                   .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );\r
+        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()\r
+                                   .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );\r
+        customizeCheckBoxMenuItem( _line_up_renderable_data_cbmi, getOptions().isLineUpRendarableNodeData() );\r
+        customizeCheckBoxMenuItem( _right_line_up_domains_cbmi, getOptions().isRightLineUpDomains() );\r
+        _jmenubar.add( _options_jmenu );\r
+    }\r
+\r
+    void buildPhylogeneticInferenceMenu() {\r
+        final InferenceManager im = getInferenceManager();\r
+        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );\r
+        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );\r
+        customizeJMenuItem( _inference_from_msa_item );\r
+        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );\r
+        if ( im.canDoMsa() ) {\r
+            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );\r
+            customizeJMenuItem( _inference_from_seqs_item );\r
+            _inference_from_seqs_item\r
+            .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );\r
+        }\r
+        else {\r
+            _inference_menu\r
+            .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );\r
+            customizeJMenuItem( _inference_from_seqs_item );\r
+            _inference_from_seqs_item.setEnabled( false );\r
+        }\r
+        _jmenubar.add( _inference_menu );\r
+    }\r
+\r
+    void buildToolsMenu() {\r
+        _tools_menu = createMenu( "Tools", getConfiguration() );\r
+        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );\r
+        customizeJMenuItem( _confcolor_item );\r
+        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );\r
+        customizeJMenuItem( _color_rank_jmi );\r
+        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );\r
+        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );\r
+        customizeJMenuItem( _taxcolor_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _remove_visual_styles_item = new JMenuItem( "Delete All Visual Styles From Nodes" ) );\r
+        _remove_visual_styles_item\r
+        .setToolTipText( "To remove all node visual styles (fonts, colors) from the current phylogeny" );\r
+        customizeJMenuItem( _remove_visual_styles_item );\r
+        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete All Colors From Branches" ) );\r
+        _remove_branch_color_item.setToolTipText( "To remove all branch color values from the current phylogeny" );\r
+        customizeJMenuItem( _remove_branch_color_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );\r
+        customizeJMenuItem( _annotate_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );\r
+        customizeJMenuItem( _midpoint_root_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _delete_selected_nodes_item = new JMenuItem( "Delete Selected Nodes" ) );\r
+        _delete_selected_nodes_item.setToolTipText( "To delete all selected external nodes" );\r
+        customizeJMenuItem( _delete_selected_nodes_item );\r
+        _tools_menu.add( _delete_not_selected_nodes_item = new JMenuItem( "Retain Selected Nodes" ) );\r
+        _delete_not_selected_nodes_item.setToolTipText( "To delete all not selected external nodes" );\r
+        customizeJMenuItem( _delete_not_selected_nodes_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );\r
+        customizeJMenuItem( _collapse_species_specific_subtrees );\r
+        _collapse_species_specific_subtrees.setToolTipText( "To (reversibly) collapse species-specific subtrees" );\r
+        _tools_menu\r
+        .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );\r
+        customizeJMenuItem( _collapse_below_threshold );\r
+        _collapse_below_threshold\r
+        .setToolTipText( "To (permanently) collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );\r
+        //\r
+        _tools_menu\r
+        .add( _collapse_below_branch_length = new JMenuItem( "Collapse Branches with Branch Lengths Below Threshold into Multifurcations" ) );\r
+        customizeJMenuItem( _collapse_below_branch_length );\r
+        _collapse_below_branch_length\r
+        .setToolTipText( "To (permanently) collapse branches with branches with branch lengths below a threshold into multifurcations" );\r
+        //\r
+        _tools_menu.addSeparator();\r
+        _tools_menu\r
+        .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );\r
+        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );\r
+        _extract_tax_code_from_node_names_jmi\r
+        .setToolTipText( "To extract SwissProt/Uniprot taxonomic codes (mnemonics) from nodes names in the form of 'xyz_CAEEL', Uniprot/NCBI identifiers form of 'xyz_6239', or scientific names form of 'xyz_Caenorhabditis_elegans'" );\r
+        _tools_menu\r
+        .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );\r
+        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );\r
+        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );\r
+        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );\r
+        customizeJMenuItem( _move_node_names_to_seq_names_jmi );\r
+        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );\r
+        customizeJMenuItem( _obtain_seq_information_jmi );\r
+        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );\r
+        _tools_menu\r
+        .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );\r
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );\r
+        _obtain_detailed_taxonomic_information_jmi\r
+        .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );\r
+        _tools_menu\r
+        .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );\r
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );\r
+        _obtain_detailed_taxonomic_information_deleting_jmi\r
+        .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _read_values_jmi = new JMenuItem( "Attach Vector/Expression Values" ) );\r
+        customizeJMenuItem( _read_values_jmi );\r
+        _read_values_jmi.setToolTipText( "To attach vector (e.g. gene expression) values to tree nodes (beta)" );\r
+        _jmenubar.add( _tools_menu );\r
+        _tools_menu.add( _read_seqs_jmi = new JMenuItem( "Attach Molecular Sequences" ) );\r
+        customizeJMenuItem( _read_seqs_jmi );\r
+        _read_seqs_jmi\r
+        .setToolTipText( "To attach molecular sequences to tree nodes (from Fasta-formatted file) (beta)" );\r
+        _jmenubar.add( _tools_menu );\r
+    }\r
+\r
+    @Override\r
+    void close() {\r
+        if ( isUnsavedDataPresent() ) {\r
+            final int r = JOptionPane.showConfirmDialog( this,\r
+                                                         "Exit despite potentially unsaved changes?",\r
+                                                         "Exit?",\r
+                                                         JOptionPane.YES_NO_OPTION );\r
+            if ( r != JOptionPane.YES_OPTION ) {\r
+                return;\r
+            }\r
+        }\r
+        exit();\r
+    }\r
+\r
+    void executeLineageInference() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {\r
+            return;\r
+        }\r
+        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Phylogeny is not rooted.",\r
+                                           "Cannot infer ancestral taxonomies",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,\r
+                                                                                  _mainpanel.getCurrentTreePanel(),\r
+                                                                                  _mainpanel.getCurrentPhylogeny()\r
+                                                                                  .copy() );\r
+        new Thread( inferrer ).start();\r
+    }\r
+\r
+    void exit() {\r
+        removeAllTextFrames();\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+        // System.exit( 0 ); //TODO reconfirm that this is OK, then remove.\r
     }\r
 \r
     void readPhylogeniesFromURL() {\r
@@ -1960,7 +2139,7 @@ public final class MainFrameApplication extends MainFrame {
                 }\r
                 else {\r
                     parser = ParserUtils.createParserDependingOnUrlContents( url, getConfiguration()\r
-                            .isValidatePhyloXmlAgainstSchema() );\r
+                                                                             .isValidatePhyloXmlAgainstSchema() );\r
                 }\r
                 if ( parser instanceof NexusPhylogeniesParser ) {\r
                     nhx_or_nexus = true;\r
@@ -1987,8 +2166,8 @@ public final class MainFrameApplication extends MainFrame {
                 JOptionPane.showMessageDialog( this,\r
                                                "Could not read from " + url + "\n"\r
                                                        + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
-                                               "Failed to read URL",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
+                                                       "Failed to read URL",\r
+                                                       JOptionPane.ERROR_MESSAGE );\r
             }\r
             catch ( final Exception e ) {\r
                 JOptionPane.showMessageDialog( this,\r
@@ -2022,206 +2201,6 @@ public final class MainFrameApplication extends MainFrame {
         System.gc();\r
     }\r
 \r
-    public void readSeqsFromFileforPI() {\r
-        // Set an initial directory if none set yet\r
-        final File my_dir = getCurrentDir();\r
-        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
-        // Open file-open dialog and set current directory\r
-        if ( my_dir != null ) {\r
-            _seqs_pi_filechooser.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );\r
-        // All done: get the seqs\r
-        final File file = _seqs_pi_filechooser.getSelectedFile();\r
-        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );\r
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            setSeqsFile( null );\r
-            setSeqs( null );\r
-            List<MolecularSequence> seqs = null;\r
-            try {\r
-                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
-                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
-                    for( final MolecularSequence seq : seqs ) {\r
-                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );\r
-                    }\r
-                }\r
-                else {\r
-                    //TODO error\r
-                }\r
-            }\r
-            catch ( final MsaFormatException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Multiple sequence file format error",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final IOException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Failed to read multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final IllegalArgumentException e ) {\r
-                setArrowCursor();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            catch ( final Exception e ) {\r
-                setArrowCursor();\r
-                e.printStackTrace();\r
-                JOptionPane.showMessageDialog( this,\r
-                                               e.getLocalizedMessage(),\r
-                                               "Unexpected error during reading of multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence file is empty",\r
-                                               "Illegal multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            if ( seqs.size() < 4 ) {\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Multiple sequence file needs to contain at least 3 sequences",\r
-                                               "Illegal multiple sequence file",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-                return;\r
-            }\r
-            //  if ( msa.getLength() < 2 ) {\r
-            //       JOptionPane.showMessageDialog( this,\r
-            //                                      "Multiple sequence alignment needs to contain at least 2 residues",\r
-            //                                      "Illegal multiple sequence file",\r
-            //                                      JOptionPane.ERROR_MESSAGE );\r
-            //       return;\r
-            //   }\r
-            System.gc();\r
-            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );\r
-            setSeqs( seqs );\r
-        }\r
-    }\r
-\r
-    private void readSpeciesTreeFromFile() {\r
-        Phylogeny t = null;\r
-        boolean exception = false;\r
-        final File my_dir = getCurrentDir();\r
-        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );\r
-        if ( my_dir != null ) {\r
-            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );\r
-        }\r
-        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );\r
-        final File file = _open_filechooser_for_species_tree.getSelectedFile();\r
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
-            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.xmlfilter ) {\r
-                try {\r
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
-                            .createPhyloXmlParserXsdValidating(), file );\r
-                    t = trees[ 0 ];\r
-                }\r
-                catch ( final Exception e ) {\r
-                    exception = true;\r
-                    exceptionOccuredDuringOpenFile( e );\r
-                }\r
-            }\r
-            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrame.tolfilter ) {\r
-                try {\r
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
-                    t = trees[ 0 ];\r
-                }\r
-                catch ( final Exception e ) {\r
-                    exception = true;\r
-                    exceptionOccuredDuringOpenFile( e );\r
-                }\r
-            }\r
-            // "*.*":\r
-            else {\r
-                try {\r
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
-                            .createPhyloXmlParserXsdValidating(), file );\r
-                    t = trees[ 0 ];\r
-                }\r
-                catch ( final Exception e ) {\r
-                    exception = true;\r
-                    exceptionOccuredDuringOpenFile( e );\r
-                }\r
-            }\r
-            if ( !exception && ( t != null ) && !t.isRooted() ) {\r
-                exception = true;\r
-                t = null;\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Species tree is not rooted",\r
-                                               "Species tree not loaded",\r
-                                               JOptionPane.ERROR_MESSAGE );\r
-            }\r
-            if ( !exception && ( t != null ) ) {\r
-                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();\r
-                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {\r
-                    final PhylogenyNode node = it.next();\r
-                    if ( !node.getNodeData().isHasTaxonomy() ) {\r
-                        exception = true;\r
-                        t = null;\r
-                        JOptionPane\r
-                                .showMessageDialog( this,\r
-                                                    "Species tree contains external node(s) without taxonomy information",\r
-                                                    "Species tree not loaded",\r
-                                                    JOptionPane.ERROR_MESSAGE );\r
-                        break;\r
-                    }\r
-                    else {\r
-                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {\r
-                            exception = true;\r
-                            t = null;\r
-                            JOptionPane.showMessageDialog( this,\r
-                                                           "Taxonomy ["\r
-                                                                   + node.getNodeData().getTaxonomy().asSimpleText()\r
-                                                                   + "] is not unique in species tree",\r
-                                                           "Species tree not loaded",\r
-                                                           JOptionPane.ERROR_MESSAGE );\r
-                            break;\r
-                        }\r
-                        else {\r
-                            tax_set.add( node.getNodeData().getTaxonomy() );\r
-                        }\r
-                    }\r
-                }\r
-            }\r
-            if ( !exception && ( t != null ) ) {\r
-                setSpeciesTree( t );\r
-                JOptionPane.showMessageDialog( this,\r
-                                               "Species tree successfully loaded",\r
-                                               "Species tree loaded",\r
-                                               JOptionPane.INFORMATION_MESSAGE );\r
-            }\r
-            _contentpane.repaint();\r
-            System.gc();\r
-        }\r
-    }\r
-\r
-    private void setArrowCursor() {\r
-        try {\r
-            _mainpanel.getCurrentTreePanel().setArrowCursor();\r
-        }\r
-        catch ( final Exception ex ) {\r
-            // Do nothing.\r
-        }\r
-    }\r
-\r
-    private void setMinNotCollapseBlValue( final double min_not_collapse_bl ) {\r
-        _min_not_collapse_bl = min_not_collapse_bl;\r
-    }\r
-\r
-    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {\r
-        _min_not_collapse = min_not_collapse;\r
-    }\r
-\r
     void setMsa( final Msa msa ) {\r
         _msa = msa;\r
     }\r
@@ -2230,10 +2209,6 @@ public final class MainFrameApplication extends MainFrame {
         _msa_file = msa_file;\r
     }\r
 \r
-    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {\r
-        _phylogenetic_inference_options = phylogenetic_inference_options;\r
-    }\r
-\r
     void setSeqs( final List<MolecularSequence> seqs ) {\r
         _seqs = seqs;\r
     }\r
@@ -2242,16 +2217,34 @@ public final class MainFrameApplication extends MainFrame {
         _seqs_file = seqs_file;\r
     }\r
 \r
-    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {\r
-        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
-        nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
+    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {\r
+        return new MainFrameApplication( phys, config );\r
     }\r
 \r
-    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {\r
-        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
-        nhx.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
-        nhx.setAllowErrorsInDistanceToParent( getOptions().isAllowErrorsInDistanceToParent() );\r
+    public static MainFrame createInstance( final Phylogeny[] phys,\r
+                                            final Configuration config,\r
+                                            final String title,\r
+                                            final File current_dir ) {\r
+        return new MainFrameApplication( phys, config, title, current_dir );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {\r
+        return new MainFrameApplication( phys, config, title );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {\r
+        return new MainFrameApplication( phys, config_file_name, title );\r
     }\r
 \r
-   \r
+    static void warnIfNotPhyloXmlValidation( final Configuration c ) {\r
+        if ( !c.isValidatePhyloXmlAgainstSchema() ) {\r
+            JOptionPane\r
+            .showMessageDialog( null,\r
+                                ForesterUtil\r
+                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",\r
+                                           80 ),\r
+                                           "Warning",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+        }\r
+    }\r
 } // MainFrameApplication.\r