in progress...
[jalview.git] / forester / java / src / org / forester / ws / seqdb / EbiDbEntry.java
index 8446c19..24e0bb5 100644 (file)
@@ -34,49 +34,188 @@ import java.util.regex.Pattern;
 import org.forester.go.GoTerm;
 import org.forester.phylogeny.data.Accession;
 import org.forester.phylogeny.data.Annotation;
+import org.forester.sequence.MolecularSequence;
 import org.forester.util.ForesterUtil;
 
 public final class EbiDbEntry implements SequenceDatabaseEntry {
+    
+    private final static boolean  DEBUG = false;
+    
+    private final static Pattern LETTERS_PATTERN = Pattern.compile( "^[A-Z]+" );
+    private final static Pattern chromosome_PATTERN = Pattern.compile( "\\s+/chromosome=\"(\\w+)\"" );
+    private final static Pattern map_PATTERN = Pattern.compile( "\\s+/map=\"([\\w\\.]+)\"" );
+    private final static Pattern gene_PATTERN = Pattern.compile( "\\s+/gene=\"(.+)\"" );
+    private final static Pattern mim_PATTERN = Pattern.compile( "\\s+/db_xref=\"MIM:(\\d+)\"" );
+    private final static Pattern taxon_PATTERN = Pattern.compile( "\\s+/db_xref=\"taxon:(\\d+)\"" );
+    private final static Pattern interpro_PATTERN = Pattern.compile( "\\s+/db_xref=\"InterPro:([A-Z0-9]+)\"" );
+    private final static Pattern uniprot_PATTERN = Pattern.compile( "\\s+/db_xref=\"UniProtKB/[A-Za-z-]*:(\\w+)\"" );
+    private final static Pattern hgnc_PATTERN = Pattern.compile( "\\s+/db_xref=\"[A-Z:]*HGNC:(\\d+)\"" );
+    private final static Pattern geneid_PATTERN = Pattern.compile( "\\s+/db_xref=\"GeneID:(\\d+)\"" );
+    private final static Pattern pdb_PATTERN = Pattern.compile( "\\s+/db_xref=\"PDB:([A-Z0-9]+)\"" );
+    private final static Pattern ec_PATTERN = Pattern.compile( "\\s+/EC_number=\"([\\.\\-\\d]+)\"" );
+    private final static Pattern product_PATTERN = Pattern.compile( "\\s+/product=\"(\\w{1,10})\"" );
+    private SortedSet<Annotation> _annotations;
+    private String                _chromosome;
+    private SortedSet<Accession>  _cross_references;
+    private String                _de;
+    private String                _gene_name;
+    private String                _map;
+    private String                _os;
+    private String                _pa;
+    private String                _provider;
+    private String                _symbol;
+    private String                _tax_id;
+  
+    private EbiDbEntry() {
+    }
+
+    @Override
+    public Object clone() throws CloneNotSupportedException {
+        throw new CloneNotSupportedException();
+    }
+
+    @Override
+    public String getAccession() {
+        return _pa;
+    }
+
+    @Override
+    public SortedSet<Annotation> getAnnotations() {
+        return _annotations;
+    }
+
+    @Override
+    public String getChromosome() {
+        return _chromosome;
+    }
+
+    @Override
+    public SortedSet<Accession> getCrossReferences() {
+        return _cross_references;
+    }
+
+    @Override
+    public String getGeneName() {
+        return _gene_name;
+    }
+
+    @Override
+    public SortedSet<GoTerm> getGoTerms() {
+        return null;
+    }
+
+    @Override
+    public String getMap() {
+        return _map;
+    }
+
+    @Override
+    public String getProvider() {
+        return _provider;
+    }
+
+    @Override
+    public String getSequenceName() {
+        return _de;
+    }
+
+    @Override
+    public String getSequenceSymbol() {
+        return _symbol;
+    }
+
+    @Override
+    public String getTaxonomyIdentifier() {
+        return _tax_id;
+    }
+
+    @Override
+    public String getTaxonomyScientificName() {
+        return _os;
+    }
+
+    @Override
+    public boolean isEmpty() {
+        return ( ForesterUtil.isEmpty( getAccession() ) && ForesterUtil.isEmpty( getSequenceName() )
+                && ForesterUtil.isEmpty( getTaxonomyScientificName() )
+                && ForesterUtil.isEmpty( getTaxonomyIdentifier() ) && ForesterUtil.isEmpty( getSequenceSymbol() ) );
+    }
+
+
+    @Override
+    public MolecularSequence getMolecularSequence() {
+        // TODO Auto-generated method stub
+        return null;
+    }
+    private void addAnnotation( final Annotation annotation ) {
+        if ( _annotations == null ) {
+            _annotations = new TreeSet<Annotation>();
+        }
+        _annotations.add( annotation );
+    }
+
+    private void addCrossReference( final Accession accession ) {
+        if ( _cross_references == null ) {
+            _cross_references = new TreeSet<Accession>();
+        }
+        if ( DEBUG ) {
+            System.out.println( "XREF ADDED: " + accession );
+        }
+        _cross_references.add( accession );
+    }
+
+    private void setAccession( final String pa ) {
+        if ( _pa == null ) {
+            _pa = pa;
+        }
+    }
+
+    private void setChromosome( final String chromosome ) {
+        _chromosome = chromosome;
+    }
+
+    private void setGeneName( final String gene_name ) {
+        if ( _gene_name == null ) {
+            _gene_name = gene_name;
+        }
+    }
 
-    //    public static SequenceDatabaseEntry createInstanceFromPlainText( final List<String> lines ) {
-    //        final EbiDbEntry e = new EbiDbEntry();
-    //        for( final String line : lines ) {
-    //            if ( line.startsWith( "PA" ) ) {
-    //                e.setPA( SequenceDbWsTools.extractFrom( line, "PA" ) );
-    //            }
-    //            else if ( line.startsWith( "DE" ) ) {
-    //                e.setDe( SequenceDbWsTools.extractFrom( line, "DE" ) );
-    //            }
-    //            else if ( line.startsWith( "OS" ) ) {
-    //                if ( line.indexOf( "(" ) > 0 ) {
-    //                    e.setOs( SequenceDbWsTools.extractFromTo( line, "OS", "(" ) );
-    //                }
-    //                else {
-    //                    e.setOs( SequenceDbWsTools.extractFrom( line, "OS" ) );
-    //                }
-    //            }
-    //            else if ( line.startsWith( "OX" ) ) {
-    //                if ( line.indexOf( "NCBI_TaxID=" ) > 0 ) {
-    //                    e.setTaxId( SequenceDbWsTools.extractFromTo( line, "NCBI_TaxID=", ";" ) );
-    //                }
-    //            }
-    //        }
-    //        return e;
-    //    }
-    public static SequenceDatabaseEntry createInstanceFromPlainTextForRefSeq( final List<String> lines ) {
-        final Pattern X_PATTERN = Pattern.compile( "^[A-Z]+" );
-        final Pattern chromosome_PATTERN = Pattern.compile( "\\s+/chromosome=\"(\\w+)\"" );
-        final Pattern map_PATTERN = Pattern.compile( "\\s+/map=\"([\\w+\\.])\"" );
-        final Pattern gene_PATTERN = Pattern.compile( "\\s+/gene=\"(.+)\"" );
-        final Pattern mim_PATTERN = Pattern.compile( "\\s+/db_xref=\"MIM:(\\d+)\"" );
-        final Pattern taxon_PATTERN = Pattern.compile( "\\s+/db_xref=\"taxon:(\\d+)\"" );
-        final Pattern interpro_PATTERN = Pattern.compile( "\\s+/db_xref=\"InterPro:([A-Z0-9]+)\"" );
-        final Pattern uniprot_PATTERN = Pattern.compile( "\\s+/db_xref=\"UniProtKB/[A-Za-z-]*:(\\w+)\"" );
-        final Pattern hgnc_PATTERN = Pattern.compile( "\\s+/db_xref=\"[A-Z:]*HGNC:(\\d+)\"" );
-        final Pattern geneid_PATTERN = Pattern.compile( "\\s+/db_xref=\"GeneID:(\\d+)\"" );
-        final Pattern pdb_PATTERN = Pattern.compile( "\\s+/db_xref=\"PDB:([A-Z0-9]+)\"" );
-        final Pattern ec_PATTERN = Pattern.compile( "\\s+/EC_number=\"([\\.\\-\\d]+)\"" );
-        final Pattern product_PATTERN = Pattern.compile( "\\s+/product=\"(\\w{1,10})\"" );
+    private void setMap( final String map ) {
+        _map = map;
+    }
+
+    private void setSequenceName( final String rec_name ) {
+        if ( _de == null ) {
+            _de = rec_name;
+        }
+    }
+
+    private void setSequenceSymbol( final String symbol ) {
+        _symbol = symbol;
+    }
+
+    private void setTaxId( final String tax_id ) {
+        if ( _tax_id == null ) {
+            _tax_id = tax_id;
+        }
+    }
+
+    private void setTaxonomyScientificName( final String os ) {
+        if ( _os == null ) {
+            _os = os;
+        }
+    }
+   
+    private static void append( final StringBuilder sb, final String s ) {
+        if ( sb.length() > 0 ) {
+            sb.append( " " );
+        }
+        sb.append( s.trim() );
+    }
+    
+    public final static SequenceDatabaseEntry createInstance( final List<String> lines ) {
+        
         final EbiDbEntry e = new EbiDbEntry();
         final StringBuilder def = new StringBuilder();
         boolean in_definition = false;
@@ -102,26 +241,26 @@ public final class EbiDbEntry implements SequenceDatabaseEntry {
                 }
                 if ( line.indexOf( "[" ) > 0 ) {
                     if ( definiton ) {
-                        x( def, ( SequenceDbWsTools.extractFromTo( line, "DEFINITION", "[" ) ) );
+                        append( def, ( SequenceDbWsTools.extractFromTo( line, "DEFINITION", "[" ) ) );
                     }
                     else {
-                        x( def, ( SequenceDbWsTools.extractFromTo( line, "DE", "[" ) ) );
+                        append( def, ( SequenceDbWsTools.extractFromTo( line, "DE", "[" ) ) );
                     }
                 }
                 else if ( line.indexOf( "." ) > 0 ) {
                     if ( definiton ) {
-                        x( def, ( SequenceDbWsTools.extractFromTo( line, "DEFINITION", "." ) ) );
+                        append( def, ( SequenceDbWsTools.extractFromTo( line, "DEFINITION", "." ) ) );
                     }
                     else {
-                        x( def, ( SequenceDbWsTools.extractFromTo( line, "DE", "." ) ) );
+                        append( def, ( SequenceDbWsTools.extractFromTo( line, "DE", "." ) ) );
                     }
                 }
                 else {
                     if ( definiton ) {
-                        x( def, ( SequenceDbWsTools.extractFrom( line, "DEFINITION" ) ) );
+                        append( def, ( SequenceDbWsTools.extractFrom( line, "DEFINITION" ) ) );
                     }
                     else {
-                        x( def, ( SequenceDbWsTools.extractFrom( line, "DE" ) ) );
+                        append( def, ( SequenceDbWsTools.extractFrom( line, "DE" ) ) );
                     }
                 }
                 if ( definiton ) {
@@ -135,7 +274,6 @@ public final class EbiDbEntry implements SequenceDatabaseEntry {
                 else {
                     e.setTaxonomyScientificName( SequenceDbWsTools.extractFrom( line, "  ORGANISM" ) );
                 }
-                //  in_def = false;
             }
             else if ( line.startsWith( "OS " ) ) {
                 if ( line.indexOf( "(" ) > 0 ) {
@@ -160,14 +298,13 @@ public final class EbiDbEntry implements SequenceDatabaseEntry {
             else {
                 in_definition = false;
             }
-            if ( !line.startsWith( "FT " ) && X_PATTERN.matcher( line ).find() ) {
+            if ( !line.startsWith( "FT " ) && LETTERS_PATTERN.matcher( line ).find() ) {
                 in_features = false;
                 in_source = false;
                 in_gene = false;
                 in_cds = false;
                 in_mrna = false;
                 in_protein = false;
-                // in_def = false;
             }
             if ( line.startsWith( "FEATURES " ) || line.startsWith( "FT " ) ) {
                 in_features = true;
@@ -208,9 +345,17 @@ public final class EbiDbEntry implements SequenceDatabaseEntry {
                 in_protein = false;
             }
             if ( in_source ) {
-                final Matcher m = taxon_PATTERN.matcher( line );
-                if ( m.find() ) {
-                    e.setTaxId( m.group( 1 ) );
+                final Matcher ti = taxon_PATTERN.matcher( line );
+                if ( ti.find() ) {
+                    e.setTaxId( ti.group( 1 ) );
+                }
+                final Matcher chr = chromosome_PATTERN.matcher( line );
+                if ( chr.find() ) {
+                    e.setChromosome( chr.group( 1 ) );
+                }
+                final Matcher map = map_PATTERN.matcher( line );
+                if ( map.find() ) {
+                    e.setMap( map.group( 1 ) );
                 }
             }
             if ( in_cds || in_gene ) {
@@ -260,390 +405,4 @@ public final class EbiDbEntry implements SequenceDatabaseEntry {
         return e;
     }
 
-    private static void x( final StringBuilder sb, final String s ) {
-        if ( sb.length() > 0 ) {
-            sb.append( " " );
-        }
-        sb.append( s.trim() );
-    }
-    // FIXME actually this is NCBI entry
-    //http://www.ebi.ac.uk/Tools/dbfetch/dbfetch/emb/AAR37336/
-    private String                _pa;
-    private String                _de;
-    private String                _os;
-    private String                _tax_id;
-    private String                _symbol;
-    private String                _provider;
-    private SortedSet<Accession>  _cross_references;
-    private SortedSet<Annotation> _annotations;
-    private String                _gene_name;
-
-    // TODO  PUBMED   15798186
-    //TODO  (FEATURES) 
-    // source /db_xref="taxon:9606"
-    // gene            1..2881  
-    // /gene="RBM39" 
-    //
-    // /db_xref="MIM:604739"  
-    // CDS
-    // /gene="RBM39"
-    // /db_xref="MIM:604739"
-    // /db_xref="InterPro:IPR002475"
-    // /product="Bcl-2"
-    // /db_xref="UniProtKB/TrEMBL:Q5J7V1" <- reparse?
-    //
-    // Protein
-    /*
-    LOCUS       NM_184234               2881 bp    mRNA    linear   PRI 16-JUN-2013
-    DEFINITION  Homo sapiens RNA binding motif protein 39 (RBM39), transcript
-            variant 1, mRNA.
-    ACCESSION   NM_184234
-    VERSION     NM_184234.2  GI:336176061
-    KEYWORDS    RefSeq.
-    SOURCE      Homo sapiens (human)
-    ORGANISM  Homo sapiens
-            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
-            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
-            Catarrhini; Hominidae; Homo.
-    REFERENCE   1  (bases 1 to 2881)
-    AUTHORS   Sillars-Hardebol,A.H., Carvalho,B., Belien,J.A., de Wit,M.,
-            Delis-van Diemen,P.M., Tijssen,M., van de Wiel,M.A., Ponten,F.,
-            Meijer,G.A. and Fijneman,R.J.
-    TITLE     CSE1L, DIDO1 and RBM39 in colorectal adenoma to carcinoma
-            progression
-    JOURNAL   Cell Oncol (Dordr) 35 (4), 293-300 (2012)
-    PUBMED   22711543
-    REMARK    GeneRIF: Data show that CSE1L, DIDO1 and RBM39 mRNA expression
-            levels correlated with chromosome 20q DNA copy number status.
-    REFERENCE   2  (bases 1 to 2881)
-    AUTHORS   Huang,G., Zhou,Z., Wang,H. and Kleinerman,E.S.
-    TITLE     CAPER-alpha alternative splicing regulates the expression of
-            vascular endothelial growth factor(1)(6)(5) in Ewing sarcoma cells
-    JOURNAL   Cancer 118 (8), 2106-2116 (2012)
-    PUBMED   22009261
-    REMARK    GeneRIF: Increased VEGF(165) expression is secondary to the
-            down-regulation of CAPER-alpha by EWS/FLI-1. CAPER-alpha mediates
-            alternative splicing and controls the shift from VEGF(189) to
-            VEGF(165) .
-    REFERENCE   3  (bases 1 to 2881)
-    AUTHORS   Han,B., Stockwin,L.H., Hancock,C., Yu,S.X., Hollingshead,M.G. and
-            Newton,D.L.
-    TITLE     Proteomic analysis of nuclei isolated from cancer cell lines
-            treated with indenoisoquinoline NSC 724998, a novel topoisomerase I
-            inhibitor
-    JOURNAL   J. Proteome Res. 9 (8), 4016-4027 (2010)
-    PUBMED   20515076
-    REMARK    Erratum:[J Proteome Res. 2011 Apr 1;10(4):2128]
-    REFERENCE   4  (bases 1 to 2881)
-    AUTHORS   Zhang,J.Y., Looi,K.S. and Tan,E.M.
-    TITLE     Identification of tumor-associated antigens as diagnostic and
-            predictive biomarkers in cancer
-    JOURNAL   Methods Mol. Biol. 520, 1-10 (2009)
-    PUBMED   19381943
-    REFERENCE   5  (bases 1 to 2881)
-    AUTHORS   Dutta,J., Fan,G. and Gelinas,C.
-    TITLE     CAPERalpha is a novel Rel-TAD-interacting factor that inhibits
-            lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein
-            v-Rel
-    JOURNAL   J. Virol. 82 (21), 10792-10802 (2008)
-    PUBMED   18753212
-    REMARK    GeneRIF: this study identifies CAPERalpha (RNA binding motif
-            protein 39) as a new transcriptional coregulator for v-Rel and
-            reveals an important role in modulating Rel's oncogenic activity.
-    REFERENCE   6  (bases 1 to 2881)
-    AUTHORS   Cazalla,D., Newton,K. and Caceres,J.F.
-    TITLE     A novel SR-related protein is required for the second step of
-            Pre-mRNA splicing
-    JOURNAL   Mol. Cell. Biol. 25 (8), 2969-2980 (2005)
-    PUBMED   15798186
-    REFERENCE   7  (bases 1 to 2881)
-    AUTHORS   Dowhan,D.H., Hong,E.P., Auboeuf,D., Dennis,A.P., Wilson,M.M.,
-            Berget,S.M. and O'Malley,B.W.
-    TITLE     Steroid hormone receptor coactivation and alternative RNA splicing
-            by U2AF65-related proteins CAPERalpha and CAPERbeta
-    JOURNAL   Mol. Cell 17 (3), 429-439 (2005)
-    PUBMED   15694343
-    REFERENCE   8  (bases 1 to 2881)
-    AUTHORS   Sun,N.N., Fastje,C.D., Wong,S.S., Sheppard,P.R., Macdonald,S.J.,
-            Ridenour,G., Hyde,J.D. and Witten,M.L.
-    TITLE     Dose-dependent transcriptome changes by metal ores on a human acute
-            lymphoblastic leukemia cell line
-    JOURNAL   Toxicol Ind Health 19 (7-10), 157-163 (2003)
-    PUBMED   15747776
-    REMARK    GeneRIF: 10 genes were down-regulated following treatment of the
-            T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h
-    REFERENCE   9  (bases 1 to 2881)
-    AUTHORS   Jung,D.J., Na,S.Y., Na,D.S. and Lee,J.W.
-    TITLE     Molecular cloning and characterization of CAPER, a novel
-            coactivator of activating protein-1 and estrogen receptors
-    JOURNAL   J. Biol. Chem. 277 (2), 1229-1234 (2002)
-    PUBMED   11704680
-    REMARK    GeneRIF: This paper describes the mouse gene.
-    REFERENCE   10 (bases 1 to 2881)
-    AUTHORS   Imai,H., Chan,E.K., Kiyosawa,K., Fu,X.D. and Tan,E.M.
-    TITLE     Novel nuclear autoantigen with splicing factor motifs identified
-            with antibody from hepatocellular carcinoma
-    JOURNAL   J. Clin. Invest. 92 (5), 2419-2426 (1993)
-    PUBMED   8227358
-    COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
-            reference sequence was derived from DC346351.1, BC141835.1 and
-            C75555.1.
-            On Jun 16, 2011 this sequence version replaced gi:35493810.
-            
-            Summary: This gene encodes a member of the U2AF65 family of
-            proteins. The encoded protein is found in the nucleus, where it
-            co-localizes with core spliceosomal proteins. It has been shown to
-            play a role in both steroid hormone receptor-mediated transcription
-            and alternative splicing, and it is also a transcriptional
-            coregulator of the viral oncoprotein v-Rel. Multiple transcript
-            variants have been observed for this gene. A related pseudogene has
-            been identified on chromosome X. [provided by RefSeq, Aug 2011].
-            
-            Transcript Variant: This variant (1) encodes the longest isoform
-            (a, also called CC1.4).
-            
-            Publication Note:  This RefSeq record includes a subset of the
-            publications that are available for this gene. Please see the Gene
-            record to access additional publications.
-            
-            ##Evidence-Data-START##
-            Transcript exon combination :: BC141835.1, L10911.1 [ECO:0000332]
-            RNAseq introns              :: mixed/partial sample support
-                                           ERS025081, ERS025082 [ECO:0000350]
-            ##Evidence-Data-END##
-            COMPLETENESS: complete on the 3' end.
-    PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
-            1-578               DC346351.1         3-580
-            579-2872            BC141835.1         429-2722
-            2873-2881           C75555.1           1-9                 c
-    FEATURES             Location/Qualifiers
-     source          1..2881
-                     /organism="Homo sapiens"
-                     /mol_type="mRNA"
-                     /db_xref="taxon:9606"
-                     /chromosome="20"
-                     /map="20q11.22"
-     gene            1..2881
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /note="RNA binding motif protein 39"
-                     /db_xref="GeneID:9584"
-                     /db_xref="HGNC:15923"
-                     /db_xref="HPRD:09201"
-                     /db_xref="MIM:604739"
-     exon            1..396
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /inference="alignment:Splign:1.39.8"
-     STS             35..262
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /standard_name="REN58946"
-                     /db_xref="UniSTS:383746"
-     misc_feature    221..223
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /note="upstream in-frame stop codon"
-     STS             299..453
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /standard_name="G64285"
-                     /db_xref="UniSTS:158667"
-     exon            397..460
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /inference="alignment:Splign:1.39.8"
-     CDS             410..2002
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /note="isoform a is encoded by transcript variant 1;
-                     coactivator of activating protein-1 and estrogen
-                     receptors; functional spliceosome-associated protein 59;
-                     RNA-binding region (RNP1, RRM) containing 2;
-                     hepatocellular carcinoma protein 1; splicing factor HCC1"
-                     /codon_start=1
-                     /product="RNA-binding protein 39 isoform a"
-                     /protein_id="NP_909122.1"
-                     /db_xref="GI:35493811"
-                     /db_xref="CCDS:CCDS13266.1"
-                     /db_xref="GeneID:9584"
-                     /db_xref="HGNC:15923"
-                     /db_xref="HPRD:09201"
-                     /db_xref="MIM:604739"
-                     /translation="MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRS
-                     HERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGP
-                     KFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQL
-                     AARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRV
-                     LGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRI
-                     ESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASS
-                     ASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAE
-                     FSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDV
-                     IEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPL
-                     PTYHNLFPDSMTATQLLVPSRR"
-     misc_feature    413..415
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /experiment="experimental evidence, no additional details
-                     recorded"
-                     /note="N-acetylalanine; propagated from
-                     UniProtKB/Swiss-Prot (Q14498.2); acetylation site"
-     
-     exon            461..510
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /inference="alignment:Splign:1.39.8"
-    
-     exon            1902..2874
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /inference="alignment:Splign:1.39.8"
-     STS             1956..2182
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /standard_name="REN58786"
-                     /db_xref="UniSTS:383586"
-     STS             2104..2148
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /standard_name="D19S1033"
-                     /db_xref="UniSTS:154759"
-     STS             2145..2400
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-                     /standard_name="REN58785"
-                     /db_xref="UniSTS:383585"
-    
-     polyA_signal    2851..2856
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-     polyA_site      2874
-                     /gene="RBM39"
-                     /gene_synonym="CAPER; CAPERalpha; FSAP59; HCC1; RNPC2"
-    ORIGIN      
-        1 atttggagct tggggcagct tctcgcgaga gcccgtgctg agggctctgt gaggccccgt
-       61 gtgtttgtgt gtgtgtatgt gtgctggtga atgtgagtac agggaagcag cggccgccat
-      121 ttcagggagc ttgtcgacgc tgtcgcaggg gtggatcctg agctgccgaa gccgccgtcc
-      181 tgctctcccg cgtgggcttc tctaattcca ttgttttttt tagattctct cgggcctagc
-      241 cgtccttgga acccgatatt cgggctgggc ggttccgcgg cctgggccta ggggcttaac
-    
-    
-    
-    */
-    private EbiDbEntry() {
-    }
-
-    private void addCrossReference( final Accession accession ) {
-        if ( _cross_references == null ) {
-            _cross_references = new TreeSet<Accession>();
-        }
-        System.out.println( "XREF ADDED: " + accession );
-        _cross_references.add( accession );
-    }
-
-    @Override
-    public Object clone() throws CloneNotSupportedException {
-        throw new CloneNotSupportedException();
-    }
-
-    @Override
-    public String getAccession() {
-        return _pa;
-    }
-
-    @Override
-    public SortedSet<Accession> getCrossReferences() {
-        return _cross_references;
-    }
-
-    @Override
-    public String getGeneName() {
-        return _gene_name;
-    }
-
-    @Override
-    public SortedSet<GoTerm> getGoTerms() {
-        return null;
-    }
-
-    @Override
-    public String getProvider() {
-        return _provider;
-    }
-
-    @Override
-    public String getSequenceName() {
-        return _de;
-    }
-
-    @Override
-    public String getSequenceSymbol() {
-        return _symbol;
-    }
-
-    private void setSequenceSymbol( final String symbol ) {
-        _symbol = symbol;
-    }
-
-    @Override
-    public String getTaxonomyIdentifier() {
-        return _tax_id;
-    }
-
-    @Override
-    public String getTaxonomyScientificName() {
-        return _os;
-    }
-
-    @Override
-    public boolean isEmpty() {
-        return ( ForesterUtil.isEmpty( getAccession() ) && ForesterUtil.isEmpty( getSequenceName() )
-                && ForesterUtil.isEmpty( getTaxonomyScientificName() )
-                && ForesterUtil.isEmpty( getTaxonomyIdentifier() ) && ForesterUtil.isEmpty( getSequenceSymbol() ) );
-    }
-
-    private void setSequenceName( final String rec_name ) {
-        if ( _de == null ) {
-            _de = rec_name;
-        }
-    }
-
-    private void setGeneName( final String gene_name ) {
-        if ( _gene_name == null ) {
-            _gene_name = gene_name;
-        }
-    }
-
-    private void setTaxonomyScientificName( final String os ) {
-        if ( _os == null ) {
-            _os = os;
-        }
-    }
-
-    private void setAccession( final String pa ) {
-        if ( _pa == null ) {
-            _pa = pa;
-        }
-    }
-
-    public void setProvider( final String provider ) {
-        _provider = provider;
-    }
-
-    private void setTaxId( final String tax_id ) {
-        if ( _tax_id == null ) {
-            _tax_id = tax_id;
-        }
-    }
-
-    @Override
-    public SortedSet<Annotation> getAnnotations() {
-        return _annotations;
-    }
-
-    private void addAnnotation( final Annotation annotation ) {
-        if ( _annotations == null ) {
-            _annotations = new TreeSet<Annotation>();
-        }
-        _annotations.add( annotation );
-    }
 }