<li><strong>Ensembl sequence fetcher.</strong> Annotated Genes,
transcripts and proteins can be retrieved via Jalview's new <a
href="features/ensemblsequencefetcher.html">Ensembl REST
- client</a>. Support for import of Ensembl data also allows:
+ client</a>. Support for import of Ensembl data allows:
<ul>
<li><strong>Sequence variant data.</strong> Jalview
- propagates variant annotation imported via Ensembl onto
+ propagates variant annotation on genomic regions onto transcripts and
protein products, complete with associated metadata such as
clinical significance.</li>
<li><strong>Aligned locus view.</strong> Transcripts
retrieved for a gene identifier via the Ensembl or
EnsemblGenomes sequence databases are automatically aligned to
- their reference genome.</li>
+ their reference genome, and introns hidden from the view.</li>
</ul></li>
<li><strong>Working with structures.</strong>
<ul>
<li><strong>More accurate structure mappings.</strong>
Jalview now utilises the PDBe's SIFTS database (at EMBL-EBI)
- to match structures to UniProt sequences, even for structures
- containing multiple copies of a sequence.</li>
+ to <a href="features/siftsmapping.html">match structures
+ to UniProt sequences</a>, even for structures containing
+ multiple copies of a sequence.</li>
<li><strong>Import structures as mmCIF</strong>. Jalview
- now downloads data from the EMBL-EBI's PDBe site as mmCIF.
- mmCIF files allow Jalview to handle very large structures,
- such as the HIV virus capsid assembly.</li>
+ <li><strong>Chimera users will need to upgrade to
+ 1.11.1.</strong>If you use Chimera to view structures downloaded by
+ Jalview 2.10, you will need to make sure you are running the
+ latest version of <a href="features/chimera.html">Chimera</a>.</li>
+ now downloads data from the EMBL-EBI's PDBe site as <a href="features/mmcif.html">mmCIF</a>.
+ This allows very large structures to be imported, such as the HIV virus capsid assembly.</li>
</ul></li>
- <li><strong>UniProt Free Text Search</strong>. The new search
+ <li><strong>UniProt Free Text Search.</strong> The new search
dialog for UniProt allows you to browse and retrieve sequences
from UniProt with free-text search and more structured queries</li>
- <li><strong>Reference sequence based alignment
- visualisation.</strong>. When a reference sequence is defined for the
- alignment, the alignment column ruler is now numbered according to
- the reference sequence. The reference sequence for alignment views
- can also be saved and restored from Jalview projects.</li>
- <li></li>
+ <li><strong>Reference sequence alignment view.</strong>.
+ Jalview 2.9 introduced support for reference sequences. In 2.10,
+ when a reference sequence is defined for the alignment, the
+ alignment column ruler is now numbered according to the reference
+ sequence. The reference sequence for alignment views can also be
+ saved and restored from Jalview projects.</li>
+ <li><strong>Ensembl and ENA 'show cross-references'
+ support.</strong>The Calculations menu's 'Show cross-references' will now
+ offer Ensembl as well as EMBLCDS and Uniprot when CDS/Protein
+ mapping data is available for download or display.</li>
</ul>
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