+/*
+ * Jalview - A Sequence Alignment Editor and Viewer ($$Version-Rel$$)
+ * Copyright (C) $$Year-Rel$$ The Jalview Authors
+ *
+ * This file is part of Jalview.
+ *
+ * Jalview is free software: you can redistribute it and/or
+ * modify it under the terms of the GNU General Public License
+ * as published by the Free Software Foundation, either version 3
+ * of the License, or (at your option) any later version.
+ *
+ * Jalview is distributed in the hope that it will be useful, but
+ * WITHOUT ANY WARRANTY; without even the implied warranty
+ * of MERCHANTABILITY or FITNESS FOR A PARTICULAR
+ * PURPOSE. See the GNU General Public License for more details.
+ *
+ * You should have received a copy of the GNU General Public License
+ * along with Jalview. If not, see <http://www.gnu.org/licenses/>.
+ * The Jalview Authors are detailed in the 'AUTHORS' file.
+ */
package jalview.datamodel;
+import java.util.Locale;
+
import java.util.HashSet;
import java.util.List;
import java.util.Set;
/*
* the sequence the mapped features are on
*/
- private final SequenceI linkedSeq;
+ private final SequenceI featureSequence;
/*
* the mapping between sequences;
- * NB this could be in either sense
+ * NB this could be in either sense (from or to featureSequence)
*/
private final Mapping mapping;
/*
- * if true, mapping is from the linked sequence, else to the linked sequence
- */
- private boolean mappingIsFromLinkedSequence;
-
- /*
- * features on linkedSeq that overlap the mapped positions
+ * features on featureSequence that overlap the mapped positions
*/
public final List<SequenceFeature> features;
* Constructor
*
* @param theMapping
- * @param from
- * the sequence mapped from (e.g. CDS)
+ * sequence mapping (which may be either to, or from, the sequence
+ * holding the linked features)
+ * @param featureSeq
+ * the sequence hosting the virtual features
* @param pos
- * the residue position in the sequence mapped to
+ * the residue position in the sequence mapped to
* @param res
- * the residue character at position pos
+ * the residue character at position pos
* @param theFeatures
- * list of mapped features found in the 'from' sequence at
- * the mapped position(s)
+ * list of mapped features found in the 'featureSeq' sequence at the
+ * mapped position(s)
*/
- public MappedFeatures(Mapping theMapping, SequenceI from, int pos,
+ public MappedFeatures(Mapping theMapping, SequenceI featureSeq, int pos,
char res, List<SequenceFeature> theFeatures)
{
mapping = theMapping;
- linkedSeq = from;
- mappingIsFromLinkedSequence = mapping.to != linkedSeq;
+ featureSequence = featureSeq;
toPosition = pos;
toResidue = res;
features = theFeatures;
* determine codon positions and canonical codon
* for a peptide-to-CDS mapping
*/
- int[] codonIntervals = mapping.getMap().locateInFrom(toPosition, toPosition);
+ int[] codonIntervals = mapping.getMap().locateInFrom(toPosition,
+ toPosition);
int[] codonPositions = codonIntervals == null ? null
: MappingUtils.flattenRanges(codonIntervals);
if (codonPositions != null && codonPositions.length == 3)
{
codonPos = codonPositions;
baseCodon = new char[3];
- int cdsStart = linkedSeq.getStart();
- baseCodon[0] = Character
- .toUpperCase(linkedSeq.getCharAt(codonPos[0] - cdsStart));
- baseCodon[1] = Character
- .toUpperCase(linkedSeq.getCharAt(codonPos[1] - cdsStart));
- baseCodon[2] = Character
- .toUpperCase(linkedSeq.getCharAt(codonPos[2] - cdsStart));
+ int cdsStart = featureSequence.getStart();
+ baseCodon[0] = Character.toUpperCase(
+ featureSequence.getCharAt(codonPos[0] - cdsStart));
+ baseCodon[1] = Character.toUpperCase(
+ featureSequence.getCharAt(codonPos[1] - cdsStart));
+ baseCodon[2] = Character.toUpperCase(
+ featureSequence.getCharAt(codonPos[2] - cdsStart));
}
else
{
/**
* Computes and returns comma-delimited HGVS notation peptide variants derived
* from codon allele variants. If no variants are found, answers an empty
- * string.
+ * string. The peptide variant is either simply read from the "CSQ:HGVSp"
+ * attribute if present, else computed based on the "alleles" attribute if
+ * present. If neither attribute is found, no variant (empty string) is
+ * returned.
*
* @param sf
- * a sequence feature (which must be one of those held in this
- * object)
+ * a sequence feature (which must be one of those held in this
+ * object)
* @return
*/
public String findProteinVariants(SequenceFeature sf)
* e.g. C,G,T gives variants G and T for base C
*/
Set<String> variantPeptides = new HashSet<>();
- String[] alleles = alls.toUpperCase().split(",");
+ String[] alleles = alls.toUpperCase(Locale.ROOT).split(",");
StringBuilder vars = new StringBuilder();
for (String allele : alleles)
{
- allele = allele.trim().toUpperCase();
+ allele = allele.trim().toUpperCase(Locale.ROOT);
if (allele.length() > 1 || "-".equals(allele))
{
continue; // multi-locus variant
*/
final int i = cdsPos == codonPos[0] ? 0
: (cdsPos == codonPos[1] ? 1 : 2);
- variantCodon[i] = allele.toUpperCase().charAt(0);
+ variantCodon[i] = allele.toUpperCase(Locale.ROOT).charAt(0);
if (variantCodon[i] == baseCodon[i])
{
continue;
*/
var.append("c.").append(String.valueOf(cdsPos))
.append(String.valueOf(baseCodon[i])).append(">")
- .append(String.valueOf(variantCodon[i]))
- .append("(p.=)");
+ .append(String.valueOf(variantCodon[i])).append("(p.=)");
}
else
{
*/
public String getLinkedSequenceName()
{
- return linkedSeq == null ? null : linkedSeq.getName();
+ return featureSequence == null ? null : featureSequence.getName();
}
/**
public int[] getMappedPositions(int begin, int end)
{
MapList map = mapping.getMap();
- return mappingIsFromLinkedSequence ? map.locateInTo(begin, end)
- : map.locateInFrom(begin, end);
+ return mapping.to == featureSequence ? map.getOverlapsInFrom(begin, end)
+ : map.getOverlapsInTo(begin, end);
}
+ /**
+ * Answers true if the linked features are on coding sequence, false if on
+ * peptide
+ *
+ * @return
+ */
public boolean isFromCds()
{
if (mapping.getMap().getFromRatio() == 3)
{
- return mappingIsFromLinkedSequence;
+ return mapping.to != featureSequence;
}
- return !mappingIsFromLinkedSequence;
+ return mapping.to == featureSequence;
}
}