added URL tree reading back
authorcmzmasek@gmail.com <cmzmasek@gmail.com@ca865154-3058-d1c3-3e42-d8f55a55bdbd>
Thu, 5 Jun 2014 17:28:04 +0000 (17:28 +0000)
committercmzmasek@gmail.com <cmzmasek@gmail.com@ca865154-3058-d1c3-3e42-d8f55a55bdbd>
Thu, 5 Jun 2014 17:28:04 +0000 (17:28 +0000)
forester/java/src/org/forester/archaeopteryx/Constants.java
forester/java/src/org/forester/archaeopteryx/MainFrame.java
forester/java/src/org/forester/archaeopteryx/MainFrameApplication.java
forester/java/src/org/forester/phylogeny/PhylogenyMethods.java
forester/java/src/org/forester/util/ForesterConstants.java

index 038f965..6172d3e 100644 (file)
@@ -42,8 +42,8 @@ public final class Constants {
     public final static boolean __SYNTH_LF                                                    = false;                                                               // TODO remove me
     public final static boolean ALLOW_DDBJ_BLAST                                              = false;
     public final static String  PRG_NAME                                                      = "Archaeopteryx";
-    final static String         VERSION                                                       = "0.989 beta";
-    final static String         PRG_DATE                                                      = "140514";
+    final static String         VERSION                                                       = "0.9891 beta";
+    final static String         PRG_DATE                                                      = "140605";
     final static String         DEFAULT_CONFIGURATION_FILE_NAME                               = "_aptx_configuration_file";
     final static String[]       DEFAULT_FONT_CHOICES                                          = { "Arial", "Helvetica",
             "Verdana", "Tahoma", "Dialog", "Lucida Sans", "SansSerif", "Sans-serif", "Sans"  };
index 4bac494..377c999 100644 (file)
-// $Id:
-// FORESTER -- software libraries and applications
-// for evolutionary biology research and applications.
-//
-// Copyright (C) 2008-2010 Christian M. Zmasek
-// All rights reserved
-//
-// This library is free software; you can redistribute it and/or
-// modify it under the terms of the GNU Lesser General Public
-// License as published by the Free Software Foundation; either
-// version 2.1 of the License, or (at your option) any later version.
-//
-// This library is distributed in the hope that it will be useful,
-// but WITHOUT ANY WARRANTY; without even the implied warranty of
-// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
-// Lesser General Public License for more details.
-//
-// You should have received a copy of the GNU Lesser General Public
-// License along with this library; if not, write to the Free Software
-// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA
-//
-// Contact: phylosoft @ gmail . com
-// WWW: https://sites.google.com/site/cmzmasek/home/software/forester
-
-package org.forester.archaeopteryx;
-
-import java.awt.Color;
-import java.awt.Component;
-import java.awt.Container;
-import java.awt.Font;
-import java.awt.event.ActionEvent;
-import java.awt.event.ActionListener;
-import java.io.File;
-import java.io.IOException;
-import java.util.LinkedList;
-import java.util.List;
-import java.util.Locale;
-import java.util.NoSuchElementException;
-import java.util.Set;
-
-import javax.swing.Box;
-import javax.swing.JApplet;
-import javax.swing.JCheckBoxMenuItem;
-import javax.swing.JFrame;
-import javax.swing.JLabel;
-import javax.swing.JMenu;
-import javax.swing.JMenuBar;
-import javax.swing.JMenuItem;
-import javax.swing.JOptionPane;
-import javax.swing.JPanel;
-import javax.swing.JRadioButtonMenuItem;
-import javax.swing.JTextField;
-import javax.swing.SwingUtilities;
-
-import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;
-import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;
-import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;
-import org.forester.archaeopteryx.tools.InferenceManager;
-import org.forester.archaeopteryx.tools.ProcessPool;
-import org.forester.archaeopteryx.tools.ProcessRunning;
-import org.forester.io.parsers.nhx.NHXParser.TAXONOMY_EXTRACTION;
-import org.forester.phylogeny.Phylogeny;
-import org.forester.phylogeny.PhylogenyMethods;
-import org.forester.phylogeny.PhylogenyMethods.DESCENDANT_SORT_PRIORITY;
-import org.forester.phylogeny.PhylogenyNode;
-import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;
-import org.forester.phylogeny.data.Annotation;
-import org.forester.phylogeny.data.NodeVisualData.NodeFill;
-import org.forester.phylogeny.data.NodeVisualData.NodeShape;
-import org.forester.sdi.GSDI;
-import org.forester.sdi.GSDIR;
-import org.forester.sdi.SDIException;
-import org.forester.util.ForesterConstants;
-import org.forester.util.ForesterUtil;
-
-public abstract class MainFrame extends JFrame implements ActionListener {
-
-    static final String         USE_MOUSEWHEEL_SHIFT_TO_ROTATE          = "In this display type, use mousewheel + Shift to rotate [or A and S]";
-    static final String         PHYLOXML_REF_TOOL_TIP                   = Constants.PHYLOXML_REFERENCE;                                                                                                                                       //TODO //FIXME
-    static final String         APTX_REF_TOOL_TIP                       = Constants.APTX_REFERENCE;
-    private static final long   serialVersionUID                        = 3655000897845508358L;
-    final static Font           menu_font                               = new Font( Configuration.getDefaultFontFamilyName(),
-                                                                                    Font.PLAIN,
-                                                                                    10 );
-    static final String         TYPE_MENU_HEADER                        = "Type";
-    static final String         RECTANGULAR_TYPE_CBMI_LABEL             = "Rectangular";
-    static final String         EURO_TYPE_CBMI_LABEL                    = "Euro Type";
-    static final String         CURVED_TYPE_CBMI_LABEL                  = "Curved";
-    static final String         TRIANGULAR_TYPE_CBMI_LABEL              = "Triangular";
-    static final String         CONVEX_TYPE_CBMI_LABEL                  = "Convex";
-    static final String         ROUNDED_TYPE_CBMI_LABEL                 = "Rounded";
-    static final String         UNROOTED_TYPE_CBMI_LABEL                = "Unrooted (alpha)";                                                                                                                                                 //TODO
-    static final String         CIRCULAR_TYPE_CBMI_LABEL                = "Circular (alpha)";                                                                                                                                                 //TODO
-    static final String         OPTIONS_HEADER                          = "Options";
-    static final String         SEARCH_SUBHEADER                        = "Search:";
-    static final String         DISPLAY_SUBHEADER                       = "Display:";
-    static final String         SEARCH_TERMS_ONLY_LABEL                 = "Match Complete Terms Only";
-    static final String         SEARCH_CASE_SENSITIVE_LABEL             = "Case Sensitive";
-    static final String         INVERSE_SEARCH_RESULT_LABEL             = "Negate Result";
-    static final String         DISPLAY_BRANCH_LENGTH_VALUES_LABEL      = "Branch Length Values";
-    static final String         COLOR_BY_TAXONOMIC_GROUP                = "Colorize by Taxonomic Group";
-    static final String         DISPLAY_SCALE_LABEL                     = "Scale";
-    static final String         NON_LINED_UP_CLADOGRAMS_LABEL           = "Non-Lined Up Cladograms";
-    static final String         UNIFORM_CLADOGRAMS_LABEL                = "Total Node Sum Dependent Cladograms";
-    static final String         LABEL_DIRECTION_LABEL                   = "Radial Labels";
-    static final String         LABEL_DIRECTION_TIP                     = "To use radial node labels in radial and unrooted display types";
-    static final String         SCREEN_ANTIALIAS_LABEL                  = "Antialias";
-    static final String         COLOR_LABELS_LABEL                      = "Colorize Labels Same as Parent Branch";
-    static final String         BG_GRAD_LABEL                           = "Background Color Gradient";
-    static final String         DISPLAY_NODE_BOXES_LABEL_EXT            = "External Node Shapes";
-    static final String         DISPLAY_NODE_BOXES_LABEL_INT            = "Internal Node Shapes";
-    static final String         SHOW_OVERVIEW_LABEL                     = "Overview";
-    static final String         FONT_SIZE_MENU_LABEL                    = "Font Size";
-    static final String         NONUNIFORM_CLADOGRAMS_LABEL             = "External Node Sum Dependent Cladograms";
-    static final String         SHOW_DOMAIN_LABELS_LABEL                = "Domain Labels";
-    static final String         SHOW_ANN_REF_SOURCE_LABEL               = "Seq Annotation Ref Sources";
-    static final String         COLOR_LABELS_TIP                        = "To use parent branch colors for node labels as well, need to turn off taxonomy dependent colorization and turn on branch colorization for this to become apparent";
-    static final String         ABBREV_SN_LABEL                         = "Abbreviate Scientific Taxonomic Names";
-    static final String         TAXONOMY_COLORIZE_NODE_SHAPES_LABEL     = "Colorize Node Shapes According to Taxonomy";
-    static final String         CYCLE_NODE_SHAPE_LABEL                  = "Cycle Node Shapes";
-    static final String         CYCLE_NODE_FILL_LABEL                   = "Cycle Node Fill Type";
-    static final String         CHOOSE_NODE_SIZE_LABEL                  = "Choose Node Shape Size";
-    static final String         SHOW_CONF_STDDEV_LABEL                  = "Confidence Standard Deviations";
-    static final String         USE_BRACKETS_FOR_CONF_IN_NH_LABEL       = "Use Brackets for Confidence Values";
-    static final String         USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL = "Use Internal Node Names for Confidence Values";
-    static final String         SHOW_BASIC_TREE_INFORMATION_LABEL       = "Basic Tree Information";
-    JMenuBar                    _jmenubar;
-    JMenu                       _file_jmenu;
-    JMenu                       _tools_menu;
-    JMenu                       _view_jmenu;
-    JMenu                       _options_jmenu;
-    JMenu                       _font_size_menu;
-    JMenu                       _help_jmenu;
-    JMenuItem[]                 _load_phylogeny_from_webservice_menu_items;
-    // Analysis menu
-    JMenu                       _analysis_menu;
-    JMenuItem                   _load_species_tree_item;
-    JMenuItem                   _gsdi_item;
-    JMenuItem                   _gsdir_item;
-    JMenuItem                   _lineage_inference;
-    // file menu:
-    JMenuItem                   _open_item;
-    JMenuItem                   _save_item;
-    JMenuItem                   _save_all_item;
-    JMenuItem                   _close_item;
-    JMenuItem                   _exit_item;
-    JMenuItem                   _new_item;
-    // tools menu:
-    JMenuItem                   _midpoint_root_item;
-    JMenuItem                   _taxcolor_item;
-    JMenuItem                   _confcolor_item;
-    JMenuItem                   _color_rank_jmi;
-    JMenuItem                   _collapse_species_specific_subtrees;
-    JMenuItem                   _collapse_below_threshold;                                                                                                                                                                                    //TODO implememt me
-    JMenuItem                   _obtain_detailed_taxonomic_information_jmi;
-    JMenuItem                   _obtain_detailed_taxonomic_information_deleting_jmi;
-    JMenuItem                   _obtain_seq_information_jmi;
-    JMenuItem                   _move_node_names_to_tax_sn_jmi;
-    JMenuItem                   _move_node_names_to_seq_names_jmi;
-    JMenuItem                   _extract_tax_code_from_node_names_jmi;
-    JMenuItem                   _annotate_item;
-    JMenuItem                   _remove_branch_color_item;
-    JMenuItem                   _remove_visual_styles_item;
-    // font size menu:
-    JMenuItem                   _super_tiny_fonts_item;
-    JMenuItem                   _tiny_fonts_item;
-    JMenuItem                   _small_fonts_item;
-    JMenuItem                   _medium_fonts_item;
-    JMenuItem                   _large_fonts_item;
-    // options menu:
-    // _  screen and print
-    JMenuItem                   _choose_font_mi;
-    JMenuItem                   _switch_colors_mi;
-    JCheckBoxMenuItem           _label_direction_cbmi;
-    // _  screen display
-    JCheckBoxMenuItem           _screen_antialias_cbmi;
-    JCheckBoxMenuItem           _background_gradient_cbmi;
-    JRadioButtonMenuItem        _non_lined_up_cladograms_rbmi;
-    JRadioButtonMenuItem        _uniform_cladograms_rbmi;
-    JRadioButtonMenuItem        _ext_node_dependent_cladogram_rbmi;
-    JCheckBoxMenuItem           _show_branch_length_values_cbmi;
-    JCheckBoxMenuItem           _color_by_taxonomic_group_cbmi;
-    JCheckBoxMenuItem           _show_scale_cbmi;                                                                                                                                                                                             //TODO fix me
-    JCheckBoxMenuItem           _show_overview_cbmi;
-    JCheckBoxMenuItem           _show_domain_labels;
-    JCheckBoxMenuItem           _show_annotation_ref_source;
-    JCheckBoxMenuItem           _abbreviate_scientific_names;
-    JCheckBoxMenuItem           _color_labels_same_as_parent_branch;
-    JMenuItem                   _overview_placment_mi;
-    JMenuItem                   _choose_minimal_confidence_mi;
-    JCheckBoxMenuItem           _show_default_node_shapes_internal_cbmi;
-    JCheckBoxMenuItem           _show_default_node_shapes_external_cbmi;
-    JMenuItem                   _cycle_node_shape_mi;
-    JMenuItem                   _cycle_node_fill_mi;
-    JMenuItem                   _choose_node_size_mi;
-    JCheckBoxMenuItem           _show_confidence_stddev_cbmi;
-    // _  print
-    JCheckBoxMenuItem           _graphics_export_visible_only_cbmi;
-    JCheckBoxMenuItem           _antialias_print_cbmi;
-    JCheckBoxMenuItem           _print_black_and_white_cbmi;
-    JCheckBoxMenuItem           _print_using_actual_size_cbmi;
-    JCheckBoxMenuItem           _graphics_export_using_actual_size_cbmi;
-    JMenuItem                   _print_size_mi;
-    JMenuItem                   _choose_pdf_width_mi;
-    // _  parsing
-    JCheckBoxMenuItem           _internal_number_are_confidence_for_nh_parsing_cbmi;
-    JRadioButtonMenuItem        _extract_taxonomy_no_rbmi;
-    JRadioButtonMenuItem        _extract_taxonomy_agressive_rbmi;
-    JRadioButtonMenuItem        _extract_taxonomy_pfam_strict_rbmi;
-    JRadioButtonMenuItem        _extract_taxonomy_pfam_relaxed_rbmi;
-    JCheckBoxMenuItem           _replace_underscores_cbmi;
-    JCheckBoxMenuItem           _allow_errors_in_distance_to_parent_cbmi;
-    JCheckBoxMenuItem           _use_brackets_for_conf_in_nh_export_cbmi;
-    JCheckBoxMenuItem           _use_internal_names_for_conf_in_nh_export_cbmi;
-    // _  search
-    JCheckBoxMenuItem           _search_case_senstive_cbmi;
-    JCheckBoxMenuItem           _search_whole_words_only_cbmi;
-    JCheckBoxMenuItem           _inverse_search_result_cbmi;
-    // type menu:
-    JMenu                       _type_menu;
-    JCheckBoxMenuItem           _rectangular_type_cbmi;
-    JCheckBoxMenuItem           _triangular_type_cbmi;
-    JCheckBoxMenuItem           _curved_type_cbmi;
-    JCheckBoxMenuItem           _convex_type_cbmi;
-    JCheckBoxMenuItem           _euro_type_cbmi;
-    JCheckBoxMenuItem           _rounded_type_cbmi;
-    JCheckBoxMenuItem           _unrooted_type_cbmi;
-    JCheckBoxMenuItem           _circular_type_cbmi;
-    // view as text menu:
-    JMenuItem                   _view_as_NH_item;
-    JMenuItem                   _view_as_XML_item;
-    JMenuItem                   _view_as_nexus_item;
-    JMenuItem                   _display_basic_information_item;
-    // help menu:
-    JMenuItem                   _about_item;
-    JMenuItem                   _help_item;
-    JMenuItem                   _website_item;
-    JMenuItem                   _phyloxml_website_item;
-    JMenuItem                   _phyloxml_ref_item;
-    JMenuItem                   _aptx_ref_item;
-    // process menu:
-    JMenu                       _process_menu;
-    // Handy pointers to child components:
-    MainPanel                   _mainpanel;
-    Container                   _contentpane;
-    final LinkedList<TextFrame> _textframes                             = new LinkedList<TextFrame>();                                                                                                                                         ;
-    Configuration               _configuration;
-    Options                     _options;
-    private Phylogeny           _species_tree;
-    InferenceManager            _inference_manager;
-    final ProcessPool           _process_pool;
-    private String              _previous_node_annotation_ref;
-
-    MainFrame() {
-        _process_pool = ProcessPool.createInstance();
-    }
-
-    /**
-     * Action performed.
-     */
-    @Override
-    public void actionPerformed( final ActionEvent e ) {
-        final Object o = e.getSource();
-        boolean is_applet = false;
-        JApplet applet = null;
-        if ( getCurrentTreePanel() != null ) {
-            is_applet = getCurrentTreePanel().isApplet();
-            if ( is_applet ) {
-                applet = getCurrentTreePanel().obtainApplet();
-            }
-        }
-        if ( o == _exit_item ) {
-            close();
-        }
-        else if ( o == _gsdi_item ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            executeGSDI();
-        }
-        else if ( o == _gsdir_item ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            executeGSDIR();
-        }
-        else if ( o == _taxcolor_item ) {
-            taxColor();
-        }
-        else if ( o == _confcolor_item ) {
-            confColor();
-        }
-        else if ( o == _color_rank_jmi ) {
-            colorRank();
-        }
-        else if ( o == _collapse_species_specific_subtrees ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().collapseSpeciesSpecificSubtrees();
-            }
-        }
-        else if ( o == _remove_branch_color_item ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            removeBranchColors();
-        }
-        else if ( o == _remove_visual_styles_item ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            removeVisualStyles();
-        }
-        else if ( o == _midpoint_root_item ) {
-            if ( isSubtreeDisplayed() ) {
-                return;
-            }
-            midpointRoot();
-        }
-        else if ( o == _annotate_item ) {
-            annotateSequences();
-        }
-        else if ( o == _switch_colors_mi ) {
-            switchColors();
-        }
-        else if ( o == _display_basic_information_item ) {
-            displayBasicInformation( getCurrentTreePanel().getTreeFile() );
-        }
-        else if ( o == _view_as_NH_item ) {
-            viewAsNH();
-        }
-        else if ( o == _view_as_XML_item ) {
-            viewAsXML();
-        }
-        else if ( o == _view_as_nexus_item ) {
-            viewAsNexus();
-        }
-        else if ( o == _super_tiny_fonts_item ) {
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().setSuperTinyFonts();
-                getCurrentTreePanel().repaint();
-            }
-        }
-        else if ( o == _tiny_fonts_item ) {
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().setTinyFonts();
-                getCurrentTreePanel().repaint();
-            }
-        }
-        else if ( o == _small_fonts_item ) {
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().setSmallFonts();
-                getCurrentTreePanel().repaint();
-            }
-        }
-        else if ( o == _medium_fonts_item ) {
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().setMediumFonts();
-                getCurrentTreePanel().repaint();
-            }
-        }
-        else if ( o == _large_fonts_item ) {
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().setLargeFonts();
-                getCurrentTreePanel().repaint();
-            }
-        }
-        else if ( o == _choose_font_mi ) {
-            chooseFont();
-        }
-        else if ( o == _choose_minimal_confidence_mi ) {
-            chooseMinimalConfidence();
-        }
-        else if ( o == _choose_node_size_mi ) {
-            chooseNodeSize( getOptions(), this );
-        }
-        else if ( o == _overview_placment_mi ) {
-            MainFrame.cycleOverview( getOptions(), getCurrentTreePanel() );
-        }
-        else if ( o == _cycle_node_fill_mi ) {
-            MainFrame.cycleNodeFill( getOptions(), getCurrentTreePanel() );
-        }
-        else if ( o == _cycle_node_shape_mi ) {
-            MainFrame.cycleNodeShape( getOptions(), getCurrentTreePanel() );
-        }
-        else if ( o == _screen_antialias_cbmi ) {
-            updateOptions( getOptions() );
-            updateScreenTextAntialias( getMainPanel().getTreePanels() );
-        }
-        else if ( o == _background_gradient_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_domain_labels ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_annotation_ref_source ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _abbreviate_scientific_names ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _color_labels_same_as_parent_branch ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_default_node_shapes_internal_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_default_node_shapes_external_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _non_lined_up_cladograms_rbmi ) {
-            updateOptions( getOptions() );
-            showWhole();
-        }
-        else if ( o == _uniform_cladograms_rbmi ) {
-            updateOptions( getOptions() );
-            showWhole();
-        }
-        else if ( o == _ext_node_dependent_cladogram_rbmi ) {
-            updateOptions( getOptions() );
-            showWhole();
-        }
-        else if ( o == _search_case_senstive_cbmi ) {
-            updateOptions( getOptions() );
-            getMainPanel().getControlPanel().search0();
-            getMainPanel().getControlPanel().search1();
-        }
-        else if ( o == _search_whole_words_only_cbmi ) {
-            updateOptions( getOptions() );
-            getMainPanel().getControlPanel().search0();
-            getMainPanel().getControlPanel().search1();
-        }
-        else if ( o == _inverse_search_result_cbmi ) {
-            updateOptions( getOptions() );
-            getMainPanel().getControlPanel().search0();
-            getMainPanel().getControlPanel().search1();
-        }
-        else if ( o == _show_scale_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_branch_length_values_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _color_by_taxonomic_group_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_confidence_stddev_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _use_brackets_for_conf_in_nh_export_cbmi ) {
-            if ( _use_brackets_for_conf_in_nh_export_cbmi.isSelected() ) {
-                _use_internal_names_for_conf_in_nh_export_cbmi.setSelected( false );
-            }
-            updateOptions( getOptions() );
-        }
-        else if ( o == _use_internal_names_for_conf_in_nh_export_cbmi ) {
-            if ( _use_internal_names_for_conf_in_nh_export_cbmi.isSelected() ) {
-                _use_brackets_for_conf_in_nh_export_cbmi.setSelected( false );
-            }
-            updateOptions( getOptions() );
-        }
-        else if ( o == _label_direction_cbmi ) {
-            updateOptions( getOptions() );
-        }
-        else if ( o == _show_overview_cbmi ) {
-            updateOptions( getOptions() );
-            if ( getCurrentTreePanel() != null ) {
-                getCurrentTreePanel().updateOvSizes();
-            }
-        }
-        else if ( ( o == _rectangular_type_cbmi ) || ( o == _triangular_type_cbmi ) || ( o == _curved_type_cbmi )
-                || ( o == _convex_type_cbmi ) || ( o == _euro_type_cbmi ) || ( o == _rounded_type_cbmi )
-                || ( o == _unrooted_type_cbmi ) || ( o == _circular_type_cbmi ) ) {
-            typeChanged( o );
-        }
-        else if ( o == _about_item ) {
-            about();
-        }
-        else if ( o == _help_item ) {
-            help();
-        }
-        else if ( o == _website_item ) {
-            try {
-                AptxUtil.openWebsite( Constants.APTX_WEB_SITE, is_applet, applet );
-            }
-            catch ( final IOException e1 ) {
-                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );
-            }
-        }
-        else if ( o == _phyloxml_website_item ) {
-            try {
-                AptxUtil.openWebsite( Constants.PHYLOXML_WEB_SITE, is_applet, applet );
-            }
-            catch ( final IOException e1 ) {
-                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );
-            }
-        }
-        else if ( o == _aptx_ref_item ) {
-            try {
-                AptxUtil.openWebsite( Constants.APTX_REFERENCE_URL, is_applet, applet );
-            }
-            catch ( final IOException e1 ) {
-                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );
-            }
-        }
-        else if ( o == _phyloxml_ref_item ) {
-            try {
-                AptxUtil.openWebsite( Constants.PHYLOXML_REFERENCE_URL, is_applet, applet );
-            }
-            catch ( final IOException e1 ) {
-                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );
-            }
-        }
-        else {
-            if ( _load_phylogeny_from_webservice_menu_items != null ) {
-                for( int i = 0; i < _load_phylogeny_from_webservice_menu_items.length; ++i ) {
-                    if ( o == _load_phylogeny_from_webservice_menu_items[ i ] ) {
-                        readPhylogeniesFromWebservice( i );
-                    }
-                }
-            }
-        }
-        _contentpane.repaint();
-    }
-
-    public Configuration getConfiguration() {
-        return _configuration;
-    }
-
-    /**
-     * This method returns the current external node data which
-     * has been selected by the user by clicking the "Return ..."
-     * menu item. This method is expected to be called from Javascript or
-     * something like it.
-     * 
-     * @return current external node data as String
-     */
-    public String getCurrentExternalNodesDataBuffer() {
-        return getCurrentTreePanel().getCurrentExternalNodesDataBufferAsString();
-    }
-
-    public int getCurrentExternalNodesDataBufferChangeCounter() {
-        return getCurrentTreePanel().getCurrentExternalNodesDataBufferChangeCounter();
-    }
-
-    public int getCurrentExternalNodesDataBufferLength() {
-        return getCurrentTreePanel().getCurrentExternalNodesDataBufferAsString().length();
-    }
-
-    public InferenceManager getInferenceManager() {
-        return _inference_manager;
-    }
-
-    public MainPanel getMainPanel() {
-        return _mainpanel;
-    }
-
-    public Options getOptions() {
-        return _options;
-    }
-
-    public ProcessPool getProcessPool() {
-        return _process_pool;
-    }
-
-    public void showTextFrame( final String s, final String title ) {
-        checkTextFrames();
-        _textframes.addLast( TextFrame.instantiate( s, title, _textframes ) );
-    }
-
-    public void showWhole() {
-        _mainpanel.getControlPanel().showWhole();
-    }
-
-    public void updateProcessMenu() {
-        // In general Swing is not thread safe.
-        // See "Swing's Threading Policy".
-        SwingUtilities.invokeLater( new Runnable() {
-
-            @Override
-            public void run() {
-                doUpdateProcessMenu();
-            }
-        } );
-    }
-
-    void activateSaveAllIfNeeded() {
-        if ( ( getMainPanel().getTabbedPane() != null ) && ( getMainPanel().getTabbedPane().getTabCount() > 1 ) ) {
-            _save_all_item.setEnabled( true );
-        }
-        else {
-            _save_all_item.setEnabled( false );
-        }
-    }
-
-    void buildFileMenu() {
-        _file_jmenu = createMenu( "File", getConfiguration() );
-        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );
-        customizeJMenuItem( _exit_item );
-        _jmenubar.add( _file_jmenu );
-    }
-
-    void buildFontSizeMenu() {
-        _font_size_menu = createMenu( FONT_SIZE_MENU_LABEL, getConfiguration() );
-        _font_size_menu.add( _super_tiny_fonts_item = new JMenuItem( "Super Tiny Fonts" ) );
-        _font_size_menu.add( _tiny_fonts_item = new JMenuItem( "Tiny Fonts" ) );
-        _font_size_menu.add( _small_fonts_item = new JMenuItem( "Small Fonts" ) );
-        _font_size_menu.add( _medium_fonts_item = new JMenuItem( "Medium Fonts" ) );
-        _font_size_menu.add( _large_fonts_item = new JMenuItem( "Large Fonts" ) );
-        customizeJMenuItem( _super_tiny_fonts_item );
-        customizeJMenuItem( _tiny_fonts_item );
-        customizeJMenuItem( _small_fonts_item );
-        customizeJMenuItem( _medium_fonts_item );
-        customizeJMenuItem( _large_fonts_item );
-        _jmenubar.add( _font_size_menu );
-    }
-
-    void buildHelpMenu() {
-        _help_jmenu = createMenu( "Help", getConfiguration() );
-        _help_jmenu.add( _help_item = new JMenuItem( "Help" ) );
-        _help_jmenu.add( _website_item = new JMenuItem( "Archaeopteryx Home" ) );
-        _aptx_ref_item = new JMenuItem( "Archaeopteryx Reference" );
-        _help_jmenu.add( _phyloxml_website_item = new JMenuItem( "phyloXML Home" ) );
-        _help_jmenu.add( _phyloxml_ref_item = new JMenuItem( "phyloXML Reference" ) );
-        _help_jmenu.addSeparator();
-        _help_jmenu.add( _about_item = new JMenuItem( "About" ) );
-        customizeJMenuItem( _help_item );
-        customizeJMenuItem( _website_item );
-        customizeJMenuItem( _phyloxml_website_item );
-        customizeJMenuItem( _aptx_ref_item );
-        customizeJMenuItem( _phyloxml_ref_item );
-        customizeJMenuItem( _about_item );
-        _phyloxml_ref_item.setToolTipText( PHYLOXML_REF_TOOL_TIP );
-        _aptx_ref_item.setToolTipText( APTX_REF_TOOL_TIP );
-        _jmenubar.add( _help_jmenu );
-    }
-
-    void buildTypeMenu() {
-        _type_menu = createMenu( TYPE_MENU_HEADER, getConfiguration() );
-        _type_menu.add( _rectangular_type_cbmi = new JCheckBoxMenuItem( MainFrame.RECTANGULAR_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _euro_type_cbmi = new JCheckBoxMenuItem( MainFrame.EURO_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _rounded_type_cbmi = new JCheckBoxMenuItem( MainFrame.ROUNDED_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _curved_type_cbmi = new JCheckBoxMenuItem( MainFrame.CURVED_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _triangular_type_cbmi = new JCheckBoxMenuItem( MainFrame.TRIANGULAR_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _convex_type_cbmi = new JCheckBoxMenuItem( MainFrame.CONVEX_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _unrooted_type_cbmi = new JCheckBoxMenuItem( MainFrame.UNROOTED_TYPE_CBMI_LABEL ) );
-        _type_menu.add( _circular_type_cbmi = new JCheckBoxMenuItem( MainFrame.CIRCULAR_TYPE_CBMI_LABEL ) );
-        customizeCheckBoxMenuItem( _rectangular_type_cbmi, false );
-        customizeCheckBoxMenuItem( _triangular_type_cbmi, false );
-        customizeCheckBoxMenuItem( _euro_type_cbmi, false );
-        customizeCheckBoxMenuItem( _rounded_type_cbmi, false );
-        customizeCheckBoxMenuItem( _curved_type_cbmi, false );
-        customizeCheckBoxMenuItem( _convex_type_cbmi, false );
-        customizeCheckBoxMenuItem( _unrooted_type_cbmi, false );
-        customizeCheckBoxMenuItem( _circular_type_cbmi, false );
-        _unrooted_type_cbmi.setToolTipText( MainFrame.USE_MOUSEWHEEL_SHIFT_TO_ROTATE );
-        _circular_type_cbmi.setToolTipText( MainFrame.USE_MOUSEWHEEL_SHIFT_TO_ROTATE );
-        initializeTypeMenu( getOptions() );
-        _jmenubar.add( _type_menu );
-    }
-
-    void buildViewMenu() {
-        _view_jmenu = createMenu( "View", getConfiguration() );
-        _view_jmenu.add( _display_basic_information_item = new JMenuItem( SHOW_BASIC_TREE_INFORMATION_LABEL ) );
-        _view_jmenu.addSeparator();
-        _view_jmenu.add( _view_as_XML_item = new JMenuItem( "as phyloXML" ) );
-        _view_jmenu.add( _view_as_NH_item = new JMenuItem( "as Newick" ) );
-        _view_jmenu.add( _view_as_nexus_item = new JMenuItem( "as Nexus" ) );
-        customizeJMenuItem( _display_basic_information_item );
-        customizeJMenuItem( _view_as_NH_item );
-        customizeJMenuItem( _view_as_XML_item );
-        customizeJMenuItem( _view_as_nexus_item );
-        _jmenubar.add( _view_jmenu );
-    }
-
-    void checkTextFrames() {
-        if ( _textframes.size() > 5 ) {
-            try {
-                if ( _textframes.getFirst() != null ) {
-                    _textframes.getFirst().removeMe();
-                }
-                else {
-                    _textframes.removeFirst();
-                }
-            }
-            catch ( final NoSuchElementException e ) {
-                // Ignore.
-            }
-        }
-    }
-
-    void close() {
-        removeAllTextFrames();
-        if ( _mainpanel != null ) {
-            _mainpanel.terminate();
-        }
-        if ( _contentpane != null ) {
-            _contentpane.removeAll();
-        }
-        setVisible( false );
-        dispose();
-    }
-
-    void colorRank() {
-        if ( _mainpanel.getCurrentTreePanel() != null ) {
-            final String[] ranks = AptxUtil.getAllPossibleRanks();
-            final String rank = ( String ) JOptionPane
-                    .showInputDialog( this,
-                                      "What rank should the colorization be based on",
-                                      "Rank Selection",
-                                      JOptionPane.QUESTION_MESSAGE,
-                                      null,
-                                      ranks,
-                                      null );
-            if ( !ForesterUtil.isEmpty( rank ) ) {
-                _mainpanel.getCurrentTreePanel().colorRank( rank );
-            }
-        }
-    }
-
-    void confColor() {
-        if ( _mainpanel.getCurrentTreePanel() != null ) {
-            _mainpanel.getCurrentTreePanel().confColor();
-        }
-    }
-
-    void customizeCheckBoxMenuItem( final JCheckBoxMenuItem item, final boolean is_selected ) {
-        if ( item != null ) {
-            item.setFont( MainFrame.menu_font );
-            if ( !getConfiguration().isUseNativeUI() ) {
-                item.setBackground( getConfiguration().getGuiMenuBackgroundColor() );
-                item.setForeground( getConfiguration().getGuiMenuTextColor() );
-            }
-            item.setSelected( is_selected );
-            item.addActionListener( this );
-        }
-    }
-
-    JMenuItem customizeJMenuItem( final JMenuItem jmi ) {
-        if ( jmi != null ) {
-            jmi.setFont( MainFrame.menu_font );
-            if ( !getConfiguration().isUseNativeUI() ) {
-                jmi.setBackground( getConfiguration().getGuiMenuBackgroundColor() );
-                jmi.setForeground( getConfiguration().getGuiMenuTextColor() );
-            }
-            jmi.addActionListener( this );
-        }
-        return jmi;
-    }
-
-    void customizeRadioButtonMenuItem( final JRadioButtonMenuItem item, final boolean is_selected ) {
-        if ( item != null ) {
-            item.setFont( MainFrame.menu_font );
-            if ( !getConfiguration().isUseNativeUI() ) {
-                item.setBackground( getConfiguration().getGuiMenuBackgroundColor() );
-                item.setForeground( getConfiguration().getGuiMenuTextColor() );
-            }
-            item.setSelected( is_selected );
-            item.addActionListener( this );
-        }
-    }
-
-    void displayBasicInformation( final File treefile ) {
-        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            String title = "Basic Information";
-            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {
-                title = title + " for \"" + _mainpanel.getCurrentPhylogeny().getName() + "\"";
-            }
-            showTextFrame( AptxUtil.createBasicInformation( _mainpanel.getCurrentPhylogeny(), treefile ), title );
-        }
-    }
-
-    void exceptionOccuredDuringOpenFile( final Exception e ) {
-        try {
-            _mainpanel.getCurrentTreePanel().setArrowCursor();
-        }
-        catch ( final Exception ex ) {
-            // Do nothing.
-        }
-        JOptionPane.showMessageDialog( this,
-                                       ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),
-                                       "Error during File|Open",
-                                       JOptionPane.ERROR_MESSAGE );
-    }
-
-    void exceptionOccuredDuringSaveAs( final Exception e ) {
-        try {
-            _mainpanel.getCurrentTreePanel().setArrowCursor();
-        }
-        catch ( final Exception ex ) {
-            // Do nothing.
-        }
-        JOptionPane.showMessageDialog( this, "Exception" + e, "Error during File|SaveAs", JOptionPane.ERROR_MESSAGE );
-    }
-
-    void executeGSDI() {
-        if ( !isOKforSDI( false, true ) ) {
-            return;
-        }
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree is not rooted.",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        final Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();
-        gene_tree.setAllNodesToNotCollapse();
-        gene_tree.recalculateNumberOfExternalDescendants( false );
-        GSDI gsdi = null;
-        final Phylogeny species_tree = getSpeciesTree().copy();
-        try {
-            gsdi = new GSDI( gene_tree, species_tree, false, true, true, true );
-        }
-        catch ( final SDIException e ) {
-            JOptionPane.showMessageDialog( this,
-                                           e.getLocalizedMessage(),
-                                           "Error during GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        catch ( final Exception e ) {
-            AptxUtil.unexpectedException( e );
-            return;
-        }
-        gene_tree.setRerootable( false );
-        gene_tree.clearHashIdToNodeMap();
-        gene_tree.recalculateNumberOfExternalDescendants( true );
-        _mainpanel.addPhylogenyInNewTab( gene_tree, getConfiguration(), "gene tree", null );
-        getMainPanel().getControlPanel().setShowEvents( true );
-        showWhole();
-        final int selected = _mainpanel.getTabbedPane().getSelectedIndex();
-        _mainpanel.addPhylogenyInNewTab( species_tree, getConfiguration(), "species tree", null );
-        showWhole();
-        _mainpanel.getTabbedPane().setSelectedIndex( selected );
-        showWhole();
-        _mainpanel.getCurrentTreePanel().setEdited( true );
-        final int poly = PhylogenyMethods.countNumberOfPolytomies( species_tree );
-        if ( gsdi.getStrippedExternalGeneTreeNodes().size() > 0 ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Duplications: " + gsdi.getDuplicationsSum() + "\n"
-                                                   + "Potential duplications: "
-                                                   + gsdi.getSpeciationOrDuplicationEventsSum() + "\n"
-                                                   + "Speciations: " + gsdi.getSpeciationsSum() + "\n"
-                                                   + "Stripped gene tree nodes: "
-                                                   + gsdi.getStrippedExternalGeneTreeNodes().size() + "\n"
-                                                   + "Taxonomy linkage based on: " + gsdi.getTaxCompBase() + "\n"
-                                                   + "Number of polytomies in species tree used: " + poly + "\n",
-                                           "GSDI successfully completed",
-                                           JOptionPane.WARNING_MESSAGE );
-        }
-        else {
-            JOptionPane.showMessageDialog( this,
-                                           "Duplications: " + gsdi.getDuplicationsSum() + "\n"
-                                                   + "Potential duplications: "
-                                                   + gsdi.getSpeciationOrDuplicationEventsSum() + "\n"
-                                                   + "Speciations: " + gsdi.getSpeciationsSum() + "\n"
-                                                   + "Stripped gene tree nodes: "
-                                                   + gsdi.getStrippedExternalGeneTreeNodes().size() + "\n"
-                                                   + "Taxonomy linkage based on: " + gsdi.getTaxCompBase() + "\n"
-                                                   + "Number of polytomies in species tree used: " + poly + "\n",
-                                           "GSDI successfully completed",
-                                           JOptionPane.INFORMATION_MESSAGE );
-        }
-    }
-
-    void executeGSDIR() {
-        if ( !isOKforSDI( false, false ) ) {
-            return;
-        }
-        final int p = PhylogenyMethods.countNumberOfPolytomies( _mainpanel.getCurrentPhylogeny() );
-        if ( ( p > 0 )
-                && !( ( p == 1 ) && ( _mainpanel.getCurrentPhylogeny().getRoot().getNumberOfDescendants() == 3 ) ) ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree is not completely binary",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        final Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();
-        gene_tree.setAllNodesToNotCollapse();
-        gene_tree.recalculateNumberOfExternalDescendants( false );
-        GSDIR gsdir = null;
-        final Phylogeny species_tree = getSpeciesTree().copy();
-        try {
-            gsdir = new GSDIR( gene_tree, species_tree, true, true, true );
-        }
-        catch ( final SDIException e ) {
-            JOptionPane.showMessageDialog( this,
-                                           e.getLocalizedMessage(),
-                                           "Error during GSDIR",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        catch ( final Exception e ) {
-            AptxUtil.unexpectedException( e );
-            return;
-        }
-        final Phylogeny result_gene_tree = gsdir.getMinDuplicationsSumGeneTree();
-        result_gene_tree.setRerootable( false );
-        result_gene_tree.clearHashIdToNodeMap();
-        result_gene_tree.recalculateNumberOfExternalDescendants( true );
-        PhylogenyMethods.orderAppearance( result_gene_tree.getRoot(), true, true, DESCENDANT_SORT_PRIORITY.NODE_NAME );
-        _mainpanel.addPhylogenyInNewTab( result_gene_tree, getConfiguration(), "gene tree", null );
-        getMainPanel().getControlPanel().setShowEvents( true );
-        showWhole();
-        final int selected = _mainpanel.getTabbedPane().getSelectedIndex();
-        _mainpanel.addPhylogenyInNewTab( species_tree, getConfiguration(), "species tree", null );
-        showWhole();
-        _mainpanel.getTabbedPane().setSelectedIndex( selected );
-        showWhole();
-        _mainpanel.getCurrentTreePanel().setEdited( true );
-        final int poly = PhylogenyMethods.countNumberOfPolytomies( species_tree );
-        if ( gsdir.getStrippedExternalGeneTreeNodes().size() > 0 ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Minimal duplications: " + gsdir.getMinDuplicationsSum() + "\n"
-                                                   + "Speciations: " + gsdir.getSpeciationsSum() + "\n"
-                                                   + "Stripped gene tree nodes: "
-                                                   + gsdir.getStrippedExternalGeneTreeNodes().size() + "\n"
-                                                   + "Taxonomy linkage based on: " + gsdir.getTaxCompBase() + "\n"
-                                                   + "Number of polytomies in species tree used: " + poly + "\n",
-                                           "GSDIR successfully completed",
-                                           JOptionPane.WARNING_MESSAGE );
-        }
-        else {
-            JOptionPane.showMessageDialog( this,
-                                           "Minimal duplications: " + gsdir.getMinDuplicationsSum() + "\n"
-                                                   + "Speciations: " + gsdir.getSpeciationsSum() + "\n"
-                                                   + "Stripped gene tree nodes: "
-                                                   + gsdir.getStrippedExternalGeneTreeNodes().size() + "\n"
-                                                   + "Taxonomy linkage based on: " + gsdir.getTaxCompBase() + "\n"
-                                                   + "Number of polytomies in species tree used: " + poly + "\n",
-                                           "GSDIR successfully completed",
-                                           JOptionPane.INFORMATION_MESSAGE );
-        }
-    }
-
-    boolean GAndSDoHaveMoreThanOneSpeciesInComman( final Phylogeny gene_tree ) {
-        if ( ( gene_tree == null ) || gene_tree.isEmpty() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree and species tree have no species in common.",
-                                           "Error during SDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else if ( gene_tree.getNumberOfExternalNodes() < 2 ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree and species tree have only one species in common.",
-                                           "Error during SDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else {
-            return true;
-        }
-    }
-
-    TreePanel getCurrentTreePanel() {
-        return getMainPanel().getCurrentTreePanel();
-    }
-
-    JMenu getHelpMenu() {
-        return _help_jmenu;
-    }
-
-    JCheckBoxMenuItem getlabelDirectionCbmi() {
-        return _label_direction_cbmi;
-    }
-
-    JMenuBar getMenuBarOfMainFrame() {
-        return _jmenubar;
-    }
-
-    final Phylogeny getSpeciesTree() {
-        return _species_tree;
-    }
-
-    void help() {
-        final StringBuilder sb = new StringBuilder();
-        sb.append( "Display options\n" );
-        sb.append( "-------------------\n" );
-        sb.append( "Use the checkboxes to select types of information to display on the tree.\n\n" );
-        sb.append( "Clickable tree nodes\n" );
-        sb.append( "--------------------\n" );
-        sb.append( "Tree nodes can be clicked, the action is determined by the 'click on node to' menu\n" );
-        sb.append( "or by right clicking:\n" );
-        sb.append( "o  Display Node Data -- display information for a node\n" );
-        sb.append( "o  Collapse/Uncollapse -- collapse and uncollapse subtree from clicked node\n" );
-        sb.append( "o  Root/Reroot -- change tree root to clicked node\n" );
-        sb.append( "o  Sub/Super Tree -- toggle between subtree from clicked node and whole tree\n" );
-        sb.append( "o  Swap Descendants -- switch descendant on either side of clicked node\n" );
-        sb.append( "o  Colorize Subtree -- color a subtree\n" );
-        sb.append( "o  Open Sequence Web -- launch a web browser to display sequence information\n" );
-        sb.append( "o  Open Taxonomy Web -- launch a web browser to display taxonomy information\n" );
-        sb.append( "-  there may be additional choices depending on this particular setup\n\n" );
-        sb.append( "Right clicking on a node always displays the information of a node.\n\n" );
-        sb.append( "Zooming\n" );
-        sb.append( "---------\n" );
-        sb.append( "The mouse wheel and the plus and minus keys control zooming.\n" );
-        sb.append( "Mouse wheel+Ctrl changes the text size.\n" );
-        sb.append( "Mouse wheel+Shift controls zooming in vertical direction only.\n" );
-        sb.append( "Use the buttons on the control panel to zoom the tree in and out, horizontally or vertically.\n" );
-        sb.append( "The entire tree can be fitted into the window by clicking the \"F\" button, or by pressing F, Delete, or Home.\n" );
-        sb.append( "The up, down, left, and right keys can be used to move the visible part (if zoomed in).\n" );
-        sb.append( "Up, down, left, and right+Shift can be used to control zooming horizontally and vertically.\n" );
-        sb.append( "Plus and minus keys+Ctrl change the text size; F+Ctrl, Delete+Ctrl, or Home+Ctrl resets it.\n\n" );
-        sb.append( "Quick tree manipulation:\n" );
-        sb.append( "------------------------\n" );
-        sb.append( "Order Subtrees -- order the tree by branch length\n" );
-        sb.append( "Uncollapse All -- uncollapse any and all collapsed branches\n\n" );
-        sb.append( "Memory problems (Java heap space error)\n" );
-        sb.append( "---------------------------------------\n" );
-        sb.append( "Since the Java default memory allocation is quite small, it might by necessary (for trees\n" );
-        sb.append( "with more than approximately 5000 external nodes) to increase the memory which Java can use, with\n" );
-        sb.append( "the '-Xmx' Java command line option. For example:\n" );
-        sb.append( "java -Xmx1024m -cp path\\to\\forester.jar org.forester.archaeopteryx.Archaeopteryx\n\n" );
-        // + "General remarks\n"
-        // + "---------------\n"
-        // +
-        // "o  The application version permits copying to the clipboard \n"
-        // +
-        // "    in the \"View\"|\"View as ...\" frame (either by control-c or button press).\n"
-        // +
-        // "o  Changes made to a subtree affect this subtree and its subtrees,\n"
-        // + "    but not any of its parent tree(s).\n"
-        // +
-        // "o  Archaeopteryx tries to detect whether the numerical values in a NH tree\n"
-        // +
-        // "    are likely to be bootstrap values instead of branch length values.\n\n"
-        // +
-        // " Remarks regarding SDI (Speciation Duplication Inference):\n"
-        // +
-        // "o  Each external node of the gene tree (in display) needs to be associated with\n"
-        // +
-        // "    a species: either directly through the \"Species\" field, or the species\n"
-        // +
-        // "    is part of the sequence name in the form \"XXXX_SPECIES\"\n"
-        // +
-        // "    (e.g. \"ACON_DROME\" or \"ACON_DROME/123-4489\" which is also acceptable).\n"
-        // +
-        // "o  A species tree for each species of the gene tree needs to be loaded with\n"
-        // +
-        // "   \"SDI\"|\"Load species tree\" prior the SDI execution.\n"
-        // +
-        // "o  !External nodes of the gene tree associated with species not present in\n"
-        // +
-        // "    the species tree are REMOVED prior to SDI execution!\n"
-        // +
-        // "o  Both the gene tree and the species tree must be completely binary.\n"
-        // +
-        // "o  Duplications and speciations are a function of the position of the root.\n"
-        // +
-        // "    Hence, after each manual \"Root/Reroot\"ing some duplications will be\n"
-        // + "    incorrect and need to be inferred again\n"
-        // +
-        // "    with: \"SDI\"|\"SDI (Speciation Duplication Inference)\n\n"
-        sb.append( "phyloXML\n" );
-        sb.append( "-------------------\n" );
-        sb.append( "Reference: " + Constants.PHYLOXML_REFERENCE + "\n" );
-        sb.append( "Website: " + Constants.PHYLOXML_WEB_SITE + "\n" );
-        sb.append( "Version: " + ForesterConstants.PHYLO_XML_VERSION + "\n" );
-        sb.append( "\n" );
-        sb.append( "For more information: https://sites.google.com/site/cmzmasek/home/software/archaeopteryx\n" );
-        sb.append( "Email: " + Constants.AUTHOR_EMAIL + "\n\n" );
-        TextFrame.instantiate( sb.toString(), "Help", _textframes );
-    }
-
-    void initializeTypeMenu( final Options options ) {
-        setTypeMenuToAllUnselected();
-        switch ( options.getPhylogenyGraphicsType() ) {
-            case CONVEX:
-                _convex_type_cbmi.setSelected( true );
-                break;
-            case CURVED:
-                _curved_type_cbmi.setSelected( true );
-                break;
-            case EURO_STYLE:
-                _euro_type_cbmi.setSelected( true );
-                break;
-            case ROUNDED:
-                _rounded_type_cbmi.setSelected( true );
-                break;
-            case TRIANGULAR:
-                _triangular_type_cbmi.setSelected( true );
-                break;
-            case UNROOTED:
-                _unrooted_type_cbmi.setSelected( true );
-                break;
-            case CIRCULAR:
-                _circular_type_cbmi.setSelected( true );
-                break;
-            default:
-                _rectangular_type_cbmi.setSelected( true );
-                break;
-        }
-    }
-
-    boolean isOKforSDI( final boolean species_tree_has_to_binary, final boolean gene_tree_has_to_binary ) {
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || _mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            return false;
-        }
-        else if ( ( getSpeciesTree() == null ) || getSpeciesTree().isEmpty() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "No species tree loaded",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else if ( species_tree_has_to_binary && !getSpeciesTree().isCompletelyBinary() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Species tree is not completely binary",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else if ( gene_tree_has_to_binary && !_mainpanel.getCurrentPhylogeny().isCompletelyBinary() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Gene tree is not completely binary",
-                                           "Cannot execute GSDI",
-                                           JOptionPane.ERROR_MESSAGE );
-            return false;
-        }
-        else {
-            return true;
-        }
-    }
-
-    boolean isSubtreeDisplayed() {
-        if ( getCurrentTreePanel() != null ) {
-            if ( getCurrentTreePanel().isCurrentTreeIsSubtree() ) {
-                JOptionPane
-                        .showMessageDialog( this,
-                                            "This operation can only be performed on a complete tree, not on the currently displayed sub-tree only.",
-                                            "Operation can not be exectuted on a sub-tree",
-                                            JOptionPane.WARNING_MESSAGE );
-                return true;
-            }
-        }
-        return false;
-    }
-
-    void midpointRoot() {
-        if ( _mainpanel.getCurrentTreePanel() != null ) {
-            _mainpanel.getCurrentTreePanel().midpointRoot();
-        }
-    }
-
-    void readPhylogeniesFromWebservice( final int i ) {
-        final UrlTreeReader reader = new UrlTreeReader( this, i );
-        new Thread( reader ).start();
-    }
-
-    void removeAllTextFrames() {
-        for( final TextFrame tf : _textframes ) {
-            if ( tf != null ) {
-                tf.close();
-            }
-        }
-        _textframes.clear();
-    }
-
-    void setConfiguration( final Configuration configuration ) {
-        _configuration = configuration;
-    }
-
-    void setInferenceManager( final InferenceManager i ) {
-        _inference_manager = i;
-    }
-
-    void setOptions( final Options options ) {
-        _options = options;
-    }
-
-    void setSelectedTypeInTypeMenu( final PHYLOGENY_GRAPHICS_TYPE type ) {
-        setTypeMenuToAllUnselected();
-        switch ( type ) {
-            case CIRCULAR:
-                _circular_type_cbmi.setSelected( true );
-                break;
-            case CONVEX:
-                _convex_type_cbmi.setSelected( true );
-                break;
-            case CURVED:
-                _curved_type_cbmi.setSelected( true );
-                break;
-            case EURO_STYLE:
-                _euro_type_cbmi.setSelected( true );
-                break;
-            case ROUNDED:
-                _rounded_type_cbmi.setSelected( true );
-                break;
-            case RECTANGULAR:
-                _rectangular_type_cbmi.setSelected( true );
-                break;
-            case TRIANGULAR:
-                _triangular_type_cbmi.setSelected( true );
-                break;
-            case UNROOTED:
-                _unrooted_type_cbmi.setSelected( true );
-                break;
-            default:
-                throw new IllegalArgumentException( "unknown type: " + type );
-        }
-    }
-
-    final void setSpeciesTree( final Phylogeny species_tree ) {
-        _species_tree = species_tree;
-    }
-
-    void setTypeMenuToAllUnselected() {
-        _convex_type_cbmi.setSelected( false );
-        _curved_type_cbmi.setSelected( false );
-        _euro_type_cbmi.setSelected( false );
-        _rounded_type_cbmi.setSelected( false );
-        _triangular_type_cbmi.setSelected( false );
-        _rectangular_type_cbmi.setSelected( false );
-        _unrooted_type_cbmi.setSelected( false );
-        _circular_type_cbmi.setSelected( false );
-    }
-
-    void switchColors() {
-        final TreeColorSet colorset = _mainpanel.getTreeColorSet();
-        final ColorSchemeChooser csc = new ColorSchemeChooser( getMainPanel(), colorset );
-        csc.setVisible( true );
-    }
-
-    void taxColor() {
-        if ( _mainpanel.getCurrentTreePanel() != null ) {
-            _mainpanel.getCurrentTreePanel().taxColor();
-        }
-    }
-
-    void typeChanged( final Object o ) {
-        updateTypeCheckboxes( getOptions(), o );
-        updateOptions( getOptions() );
-        if ( getCurrentTreePanel() != null ) {
-            final PHYLOGENY_GRAPHICS_TYPE previous_type = getCurrentTreePanel().getPhylogenyGraphicsType();
-            final PHYLOGENY_GRAPHICS_TYPE new_type = getOptions().getPhylogenyGraphicsType();
-            if ( ( ( previous_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) && ( new_type != PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) )
-                    || ( ( previous_type == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) && ( new_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) )
-                    || ( ( previous_type != PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) && ( new_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) )
-                    || ( ( previous_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) && ( new_type == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) ) {
-                getCurrentTreePanel().getControlPanel().showWhole();
-            }
-            if ( getCurrentTreePanel().isPhyHasBranchLengths() && ( new_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) {
-                getCurrentTreePanel().getControlPanel().setDrawPhylogramEnabled( true );
-            }
-            else {
-                getCurrentTreePanel().getControlPanel().setDrawPhylogramEnabled( false );
-            }
-            getCurrentTreePanel().setPhylogenyGraphicsType( getOptions().getPhylogenyGraphicsType() );
-            updateScreenTextAntialias( getMainPanel().getTreePanels() );
-            if ( getCurrentTreePanel().getControlPanel().getDynamicallyHideData() != null ) {
-                if ( new_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) {
-                    getCurrentTreePanel().getControlPanel().getDynamicallyHideData().setEnabled( false );
-                }
-                else {
-                    getCurrentTreePanel().getControlPanel().getDynamicallyHideData().setEnabled( true );
-                }
-            }
-        }
-    }
-
-    void updateOptions( final Options options ) {
-        options.setAntialiasScreen( ( _screen_antialias_cbmi != null ) && _screen_antialias_cbmi.isSelected() );
-        options.setBackgroundColorGradient( ( _background_gradient_cbmi != null )
-                && _background_gradient_cbmi.isSelected() );
-        options.setShowDomainLabels( ( _show_domain_labels != null ) && _show_domain_labels.isSelected() );
-        options.setShowAnnotationRefSource( ( _show_annotation_ref_source != null )
-                && _show_annotation_ref_source.isSelected() );
-        options.setAbbreviateScientificTaxonNames( ( _abbreviate_scientific_names != null )
-                && _abbreviate_scientific_names.isSelected() );
-        options.setColorLabelsSameAsParentBranch( ( _color_labels_same_as_parent_branch != null )
-                && _color_labels_same_as_parent_branch.isSelected() );
-        options.setShowDefaultNodeShapesInternal( ( _show_default_node_shapes_internal_cbmi != null )
-                && _show_default_node_shapes_internal_cbmi.isSelected() );
-        options.setShowDefaultNodeShapesExternal( ( _show_default_node_shapes_external_cbmi != null )
-                && _show_default_node_shapes_external_cbmi.isSelected() );
-        if ( ( _non_lined_up_cladograms_rbmi != null ) && ( _non_lined_up_cladograms_rbmi.isSelected() ) ) {
-            options.setCladogramType( CLADOGRAM_TYPE.NON_LINED_UP );
-        }
-        else if ( ( _uniform_cladograms_rbmi != null ) && ( _uniform_cladograms_rbmi.isSelected() ) ) {
-            options.setCladogramType( CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );
-        }
-        else if ( ( _ext_node_dependent_cladogram_rbmi != null ) && ( _ext_node_dependent_cladogram_rbmi.isSelected() ) ) {
-            options.setCladogramType( CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );
-        }
-        options.setSearchCaseSensitive( ( _search_case_senstive_cbmi != null )
-                && _search_case_senstive_cbmi.isSelected() );
-        if ( ( _show_scale_cbmi != null ) && _show_scale_cbmi.isEnabled() ) {
-            options.setShowScale( _show_scale_cbmi.isSelected() );
-        }
-        if ( _label_direction_cbmi != null ) {
-            if ( _label_direction_cbmi.isSelected() ) {
-                options.setNodeLabelDirection( NODE_LABEL_DIRECTION.RADIAL );
-            }
-            else {
-                options.setNodeLabelDirection( NODE_LABEL_DIRECTION.HORIZONTAL );
-            }
-        }
-        options.setShowOverview( ( _show_overview_cbmi != null ) && _show_overview_cbmi.isSelected() );
-        options.setShowConfidenceStddev( ( _show_confidence_stddev_cbmi != null )
-                && _show_confidence_stddev_cbmi.isSelected() );
-        if ( ( _show_branch_length_values_cbmi != null ) && _show_branch_length_values_cbmi.isEnabled() ) {
-            options.setShowBranchLengthValues( _show_branch_length_values_cbmi.isSelected() );
-        }
-        if ( ( _color_by_taxonomic_group_cbmi != null ) && _color_by_taxonomic_group_cbmi.isEnabled() ) {
-            options.setColorByTaxonomicGroup( _color_by_taxonomic_group_cbmi.isSelected() );
-        }
-        options.setPrintUsingActualSize( ( _print_using_actual_size_cbmi != null )
-                && ( _print_using_actual_size_cbmi.isSelected() ) );
-        options.setGraphicsExportUsingActualSize( ( _graphics_export_using_actual_size_cbmi != null )
-                && ( _graphics_export_using_actual_size_cbmi.isSelected() ) );
-        options.setAntialiasPrint( ( _antialias_print_cbmi != null ) && _antialias_print_cbmi.isSelected() );
-        if ( ( _use_brackets_for_conf_in_nh_export_cbmi != null )
-                && _use_brackets_for_conf_in_nh_export_cbmi.isSelected() ) {
-            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );
-        }
-        else if ( ( _use_internal_names_for_conf_in_nh_export_cbmi != null )
-                && _use_internal_names_for_conf_in_nh_export_cbmi.isSelected() ) {
-            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );
-        }
-        else {
-            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.NONE );
-        }
-        options.setPrintBlackAndWhite( ( _print_black_and_white_cbmi != null )
-                && _print_black_and_white_cbmi.isSelected() );
-        options.setInternalNumberAreConfidenceForNhParsing( ( _internal_number_are_confidence_for_nh_parsing_cbmi != null )
-                && _internal_number_are_confidence_for_nh_parsing_cbmi.isSelected() );
-        if ( ( _extract_taxonomy_pfam_strict_rbmi != null ) && _extract_taxonomy_pfam_strict_rbmi.isSelected() ) {
-            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );
-        }
-        else if ( ( _extract_taxonomy_pfam_relaxed_rbmi != null ) && _extract_taxonomy_pfam_relaxed_rbmi.isSelected() ) {
-            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );
-        }
-        else if ( ( _extract_taxonomy_agressive_rbmi != null ) && _extract_taxonomy_agressive_rbmi.isSelected() ) {
-            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.AGGRESSIVE );
-        }
-        else if ( ( _extract_taxonomy_no_rbmi != null ) && _extract_taxonomy_no_rbmi.isSelected() ) {
-            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.NO );
-        }
-        options.setReplaceUnderscoresInNhParsing( ( _replace_underscores_cbmi != null )
-                && _replace_underscores_cbmi.isSelected() );
-        options.setAllowErrorsInDistanceToParent( ( _allow_errors_in_distance_to_parent_cbmi != null )
-                && _allow_errors_in_distance_to_parent_cbmi.isSelected() );
-        options.setMatchWholeTermsOnly( ( _search_whole_words_only_cbmi != null )
-                && _search_whole_words_only_cbmi.isSelected() );
-        options.setInverseSearchResult( ( _inverse_search_result_cbmi != null )
-                && _inverse_search_result_cbmi.isSelected() );
-        if ( _graphics_export_visible_only_cbmi != null ) {
-            options.setGraphicsExportVisibleOnly( _graphics_export_visible_only_cbmi.isSelected() );
-            if ( _graphics_export_visible_only_cbmi.isSelected() && ( _graphics_export_using_actual_size_cbmi != null ) ) {
-                _graphics_export_using_actual_size_cbmi.setSelected( true );
-                _graphics_export_using_actual_size_cbmi.setEnabled( false );
-            }
-            else {
-                _graphics_export_using_actual_size_cbmi.setEnabled( true );
-            }
-        }
-        if ( ( _rectangular_type_cbmi != null ) && _rectangular_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        }
-        else if ( ( _triangular_type_cbmi != null ) && _triangular_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.TRIANGULAR );
-        }
-        else if ( ( _curved_type_cbmi != null ) && _curved_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CURVED );
-        }
-        else if ( ( _convex_type_cbmi != null ) && _convex_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CONVEX );
-        }
-        else if ( ( _euro_type_cbmi != null ) && _euro_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE );
-        }
-        else if ( ( _rounded_type_cbmi != null ) && _rounded_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.ROUNDED );
-        }
-        else if ( ( _unrooted_type_cbmi != null ) && _unrooted_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.UNROOTED );
-        }
-        else if ( ( _circular_type_cbmi != null ) && _circular_type_cbmi.isSelected() ) {
-            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CIRCULAR );
-        }
-    }
-
-    void updateTypeCheckboxes( final Options options, final Object o ) {
-        setTypeMenuToAllUnselected();
-        ( ( JCheckBoxMenuItem ) o ).setSelected( true );
-    }
-
-    void viewAsNexus() {
-        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            String title = "Nexus";
-            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {
-                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;
-            }
-            showTextFrame( _mainpanel.getCurrentPhylogeny().toNexus( getOptions().getNhConversionSupportValueStyle() ),
-                           title );
-        }
-    }
-
-    void viewAsNH() {
-        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            String title = "New Hampshire";
-            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {
-                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;
-            }
-            showTextFrame( _mainpanel.getCurrentPhylogeny().toNewHampshire( getOptions()
-                                   .getNhConversionSupportValueStyle() ),
-                           title );
-        }
-    }
-
-    void viewAsXML() {
-        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {
-            String title = "phyloXML";
-            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {
-                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;
-            }
-            showTextFrame( _mainpanel.getCurrentPhylogeny().toPhyloXML( 0 ), title );
-        }
-    }
-
-    private void annotateSequences() {
-        if ( getCurrentTreePanel() != null ) {
-            final Set<Long> nodes = getCurrentTreePanel().getFoundNodes0();
-            if ( ( nodes == null ) || nodes.isEmpty() ) {
-                JOptionPane
-                        .showMessageDialog( this,
-                                            "Need to select nodes, either via direct selection or via the \"Search\" function",
-                                            "No nodes selected for annotation",
-                                            JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            final Phylogeny phy = getMainPanel().getCurrentPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final JTextField ref_field = new JTextField( 10 );
-                final JTextField desc_filed = new JTextField( 20 );
-                ref_field.setText( ForesterUtil.isEmpty( getPreviousNodeAnnotationReference() ) ? ""
-                        : getPreviousNodeAnnotationReference() );
-                final JPanel my_panel = new JPanel();
-                my_panel.add( new JLabel( "Reference " ) );
-                my_panel.add( ref_field );
-                my_panel.add( Box.createHorizontalStrut( 15 ) );
-                my_panel.add( new JLabel( "Description " ) );
-                my_panel.add( desc_filed );
-                final int result = JOptionPane.showConfirmDialog( null,
-                                                                  my_panel,
-                                                                  "Enter the sequence annotation(s) for the "
-                                                                          + nodes.size() + " selected nodes",
-                                                                  JOptionPane.OK_CANCEL_OPTION );
-                if ( result == JOptionPane.OK_OPTION ) {
-                    String ref = ref_field.getText();
-                    String desc = desc_filed.getText();
-                    if ( !ForesterUtil.isEmpty( ref ) ) {
-                        ref = ref.trim();
-                        ref = ref.replaceAll( "\\s+", " " );
-                        if ( ( ref.indexOf( ':' ) < 1 ) || ( ref.indexOf( ':' ) > ref.length() - 2 )
-                                || ( ref.length() < 3 ) ) {
-                            JOptionPane.showMessageDialog( this,
-                                                           "Reference needs to be in the form of \"GO:1234567\"",
-                                                           "Illegal Format for Annotation Reference",
-                                                           JOptionPane.ERROR_MESSAGE );
-                            return;
-                        }
-                    }
-                    if ( ref != null ) {
-                        setPreviousNodeAnnotationReference( ref );
-                    }
-                    if ( desc != null ) {
-                        desc = desc.trim();
-                        desc = desc.replaceAll( "\\s+", " " );
-                    }
-                    if ( !ForesterUtil.isEmpty( ref ) || !ForesterUtil.isEmpty( desc ) ) {
-                        for( final Long id : nodes ) {
-                            final PhylogenyNode n = phy.getNode( id );
-                            ForesterUtil.ensurePresenceOfSequence( n );
-                            final Annotation ann = ForesterUtil.isEmpty( ref ) ? new Annotation()
-                                    : new Annotation( ref );
-                            if ( !ForesterUtil.isEmpty( desc ) ) {
-                                ann.setDesc( desc );
-                            }
-                            n.getNodeData().getSequence().addAnnotation( ann );
-                        }
-                    }
-                    getMainPanel().getControlPanel().showAnnotations();
-                }
-            }
-        }
-    }
-
-    private void chooseFont() {
-        final FontChooser fc = new FontChooser();
-        fc.setFont( getMainPanel().getTreeFontSet().getLargeFont() );
-        fc.showDialog( this, "Select the Base Font" );
-        getMainPanel().getTreeFontSet().setBaseFont( fc.getFont() );
-    }
-
-    private void chooseMinimalConfidence() {
-        final String s = ( String ) JOptionPane
-                .showInputDialog( this,
-                                  "Please enter the minimum for confidence values to be displayed.\n"
-                                          + "[current value: " + getOptions().getMinConfidenceValue() + "]\n",
-                                  "Minimal Confidence Value",
-                                  JOptionPane.QUESTION_MESSAGE,
-                                  null,
-                                  null,
-                                  getOptions().getMinConfidenceValue() );
-        if ( !ForesterUtil.isEmpty( s ) ) {
-            boolean success = true;
-            double m = 0.0;
-            final String m_str = s.trim();
-            if ( !ForesterUtil.isEmpty( m_str ) ) {
-                try {
-                    m = Double.parseDouble( m_str );
-                }
-                catch ( final Exception ex ) {
-                    success = false;
-                }
-            }
-            else {
-                success = false;
-            }
-            if ( success && ( m >= 0.0 ) ) {
-                getOptions().setMinConfidenceValue( m );
-            }
-        }
-    }
-
-    private void doUpdateProcessMenu() {
-        if ( _process_pool.size() > 0 ) {
-            if ( _process_menu == null ) {
-                _process_menu = createMenu( "", getConfiguration() );
-                _process_menu.setForeground( Color.RED );
-            }
-            _process_menu.removeAll();
-            final String text = "processes running: " + _process_pool.size();
-            _process_menu.setText( text );
-            _jmenubar.add( _process_menu );
-            for( int i = 0; i < _process_pool.size(); ++i ) {
-                final ProcessRunning p = _process_pool.getProcessByIndex( i );
-                _process_menu.add( customizeJMenuItem( new JMenuItem( p.getName() + " [" + p.getStart() + "]" ) ) );
-            }
-        }
-        else {
-            if ( _process_menu != null ) {
-                _process_menu.removeAll();
-                _jmenubar.remove( _process_menu );
-            }
-        }
-        _jmenubar.validate();
-        _jmenubar.repaint();
-        repaint();
-    }
-
-    private String getPreviousNodeAnnotationReference() {
-        return _previous_node_annotation_ref;
-    }
-
-    private void removeBranchColors() {
-        if ( getMainPanel().getCurrentPhylogeny() != null ) {
-            AptxUtil.removeBranchColors( getMainPanel().getCurrentPhylogeny() );
-        }
-    }
-
-    private void removeVisualStyles() {
-        if ( getMainPanel().getCurrentPhylogeny() != null ) {
-            AptxUtil.removeVisualStyles( getMainPanel().getCurrentPhylogeny() );
-        }
-    }
-
-    private void setPreviousNodeAnnotationReference( final String previous_node_annotation_ref ) {
-        _previous_node_annotation_ref = previous_node_annotation_ref;
-    }
-
-    /**
-     * Display the about box.
-     */
-    static void about() {
-        final StringBuffer about = new StringBuffer( "Archaeopteryx\nVersion " + Constants.VERSION + "\n" );
-        about.append( "Copyright (C) 2013 Christian M. Zmasek\n" );
-        about.append( "All Rights Reserved\n" );
-        about.append( "License: GNU Lesser General Public License (LGPL)\n" );
-        about.append( "Last modified: " + Constants.PRG_DATE + "\n" );
-        about.append( "Based on: " + ForesterUtil.getForesterLibraryInformation() + "\n" );
-        about.append( "phyloXML version : " + ForesterConstants.PHYLO_XML_VERSION + "\n" );
-        about.append( "phyloXML location: " + ForesterConstants.PHYLO_XML_LOCATION + "\n" );
-        if ( !ForesterUtil.isEmpty( ForesterUtil.JAVA_VERSION ) && !ForesterUtil.isEmpty( ForesterUtil.JAVA_VENDOR ) ) {
-            about.append( "[your Java version: " + ForesterUtil.JAVA_VERSION + " " + ForesterUtil.JAVA_VENDOR + "]\n" );
-        }
-        if ( !ForesterUtil.isEmpty( ForesterUtil.OS_NAME ) && !ForesterUtil.isEmpty( ForesterUtil.OS_ARCH )
-                && !ForesterUtil.isEmpty( ForesterUtil.OS_VERSION ) ) {
-            about.append( "[your OS: " + ForesterUtil.OS_NAME + " " + ForesterUtil.OS_ARCH + " "
-                    + ForesterUtil.OS_VERSION + "]\n" );
-        }
-        final Runtime rt = java.lang.Runtime.getRuntime();
-        final long free_memory = rt.freeMemory() / 1000000;
-        final long total_memory = rt.totalMemory() / 1000000;
-        about.append( "[free memory: " + free_memory + "MB, total memory: " + total_memory + "MB]\n" );
-        about.append( "[locale: " + Locale.getDefault() + "]\n" );
-        about.append( "References:\n" );
-        about.append( Constants.PHYLOXML_REFERENCE_SHORT + "\n" );
-        about.append( "For more information & download:\n" );
-        about.append( Constants.APTX_WEB_SITE + "\n" );
-        about.append( "Comments: " + Constants.AUTHOR_EMAIL );
-        JOptionPane.showMessageDialog( null, about, Constants.PRG_NAME, JOptionPane.PLAIN_MESSAGE );
-    }
-
-    static void chooseNodeSize( final Options options, final Component parent ) {
-        final String s = ( String ) JOptionPane.showInputDialog( parent,
-                                                                 "Please enter the default size for node shapes.\n"
-                                                                         + "[current value: "
-                                                                         + options.getDefaultNodeShapeSize() + "]\n",
-                                                                 "Node Shape Size",
-                                                                 JOptionPane.QUESTION_MESSAGE,
-                                                                 null,
-                                                                 null,
-                                                                 options.getDefaultNodeShapeSize() );
-        if ( !ForesterUtil.isEmpty( s ) ) {
-            boolean success = true;
-            double m = 0.0;
-            final String m_str = s.trim();
-            if ( !ForesterUtil.isEmpty( m_str ) ) {
-                try {
-                    m = Double.parseDouble( m_str );
-                }
-                catch ( final Exception ex ) {
-                    success = false;
-                }
-            }
-            else {
-                success = false;
-            }
-            if ( success && ( m >= 0.0 ) ) {
-                final short size = ForesterUtil.roundToShort( m );
-                if ( size >= 0.0 ) {
-                    options.setDefaultNodeShapeSize( size );
-                }
-            }
-        }
-    }
-
-    static String createCurrentFontDesc( final TreeFontSet tree_font_set ) {
-        return tree_font_set.getLargeFont().getFamily() + " " + tree_font_set.getLargeFont().getSize();
-    }
-
-    static JMenu createMenu( final String title, final Configuration conf ) {
-        final JMenu jmenu = new JMenu( title );
-        if ( !conf.isUseNativeUI() ) {
-            jmenu.setFont( MainFrame.menu_font );
-            jmenu.setBackground( conf.getGuiMenuBackgroundColor() );
-            jmenu.setForeground( conf.getGuiMenuTextColor() );
-        }
-        return jmenu;
-    }
-
-    static JMenuItem customizeMenuItemAsLabel( final JMenuItem label, final Configuration configuration ) {
-        label.setFont( MainFrame.menu_font.deriveFont( Font.BOLD ) );
-        if ( !configuration.isUseNativeUI() ) {
-            label.setBackground( configuration.getGuiMenuBackgroundColor() );
-            label.setForeground( configuration.getGuiMenuTextColor() );
-            label.setOpaque( true );
-        }
-        label.setSelected( false );
-        label.setEnabled( false );
-        return label;
-    }
-
-    static void cycleNodeFill( final Options op, final TreePanel tree_panel ) {
-        switch ( op.getDefaultNodeFill() ) {
-            case GRADIENT:
-                op.setDefaultNodeFill( NodeFill.SOLID );
-                break;
-            case NONE:
-                op.setDefaultNodeFill( NodeFill.GRADIENT );
-                break;
-            case SOLID:
-                op.setDefaultNodeFill( NodeFill.NONE );
-                break;
-            default:
-                throw new RuntimeException( "unknown fill: " + op.getDefaultNodeFill() );
-        }
-    }
-
-    static void cycleNodeShape( final Options op, final TreePanel tree_panel ) {
-        switch ( op.getDefaultNodeShape() ) {
-            case CIRCLE:
-                op.setDefaultNodeShape( NodeShape.RECTANGLE );
-                break;
-            case RECTANGLE:
-                op.setDefaultNodeShape( NodeShape.CIRCLE );
-                break;
-            default:
-                throw new RuntimeException( "unknown shape: " + op.getDefaultNodeShape() );
-        }
-    }
-
-    static void cycleOverview( final Options op, final TreePanel tree_panel ) {
-        switch ( op.getOvPlacement() ) {
-            case LOWER_LEFT:
-                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.UPPER_LEFT );
-                break;
-            case LOWER_RIGHT:
-                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.LOWER_LEFT );
-                break;
-            case UPPER_LEFT:
-                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.UPPER_RIGHT );
-                break;
-            case UPPER_RIGHT:
-                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.LOWER_RIGHT );
-                break;
-            default:
-                throw new RuntimeException( "unknown placement: " + op.getOvPlacement() );
-        }
-        if ( tree_panel != null ) {
-            tree_panel.updateOvSettings();
-        }
-    }
-
-    static void setCycleNodeFillMenuItem( final JMenuItem mi, final Options options ) {
-        if ( ( options != null ) && ( options.getDefaultNodeFill() != null ) ) {
-            mi.setText( "Cycle Node Shape Fill Type... (current: "
-                    + options.getDefaultNodeFill().toString().toLowerCase() + ")" );
-        }
-        else {
-            mi.setText( "Cycle Node Shape Fill Type..." );
-        }
-    }
-
-    static void setCycleNodeShapeMenuItem( final JMenuItem mi, final Options options ) {
-        if ( ( options != null ) && ( options.getDefaultNodeShape() != null ) ) {
-            mi.setText( "Cycle Node Shape Fill Type... (current: "
-                    + options.getDefaultNodeShape().toString().toLowerCase() + ")" );
-        }
-        else {
-            mi.setText( "Cycle Node Shape Fill Type..." );
-        }
-    }
-
-    static void setOvPlacementColorChooseMenuItem( final JMenuItem mi, final Options options ) {
-        if ( ( options != null ) && ( options.getOvPlacement() != null ) ) {
-            mi.setText( "Cycle Overview Placement... (current: " + options.getOvPlacement() + ")" );
-        }
-        else {
-            mi.setText( "Cycle Overview Placement..." );
-        }
-    }
-
-    static void setTextColorChooseMenuItem( final JMenuItem mi, final TreePanel tree_panel ) {
-        if ( ( tree_panel != null ) && ( tree_panel.getTreeColorSet() != null ) ) {
-            mi.setText( "Select Color Scheme... (current: " + tree_panel.getTreeColorSet().getCurrentColorSchemeName()
-                    + ")" );
-        }
-        else {
-            mi.setText( "Select Color Scheme..." );
-        }
-    }
-
-    static void setTextForFontChooserMenuItem( final JMenuItem mi, final String font_desc ) {
-        mi.setText( "Select Default Font... (current: " + font_desc + ")" );
-    }
-
-    static void setTextMinSupportMenuItem( final JMenuItem mi, final Options options, final TreePanel current_tree_panel ) {
-        if ( ( current_tree_panel == null ) || ( current_tree_panel.getPhylogeny() == null ) ) {
-            mi.setEnabled( true );
-        }
-        else if ( AptxUtil.isHasAtLeastOneBranchWithSupportValues( current_tree_panel.getPhylogeny() ) ) {
-            mi.setEnabled( true );
-        }
-        else {
-            mi.setEnabled( false );
-        }
-        mi.setText( "Enter Min Confidence Value... (current: " + options.getMinConfidenceValue() + ")" );
-    }
-
-    static void setTextNodeSizeMenuItem( final JMenuItem mi, final Options options ) {
-        mi.setText( "Enter Default Node Shape Size... (current: " + options.getDefaultNodeShapeSize() + ")" );
-    }
-
-    static void updateOptionsMenuDependingOnPhylogenyType( final MainPanel main_panel,
-                                                           final JCheckBoxMenuItem scale,
-                                                           final JCheckBoxMenuItem branch_lengths,
-                                                           final JRadioButtonMenuItem non_lined_up,
-                                                           final JRadioButtonMenuItem uniform_clado,
-                                                           final JRadioButtonMenuItem nonuniform_clado,
-                                                           final JCheckBoxMenuItem label_direction_cbmi ) {
-        final TreePanel tree_panel = main_panel.getCurrentTreePanel();
-        final ControlPanel control = main_panel.getControlPanel();
-        final Options options = main_panel.getOptions();
-        scale.setSelected( options.isShowScale() );
-        branch_lengths.setSelected( options.isShowBranchLengthValues() );
-        // non_lined_up.setSelected( options.isNonLinedUpCladogram() );
-        if ( ( tree_panel != null ) && ( !tree_panel.isPhyHasBranchLengths() ) ) {
-            scale.setSelected( false );
-            scale.setEnabled( false );
-            branch_lengths.setSelected( false );
-            branch_lengths.setEnabled( false );
-        }
-        else if ( ( tree_panel != null ) && !control.isDrawPhylogram() ) {
-            scale.setSelected( false );
-            scale.setEnabled( false );
-            branch_lengths.setEnabled( true );
-        }
-        else {
-            scale.setEnabled( true );
-            branch_lengths.setEnabled( true );
-        }
-        if ( ( tree_panel != null )
-                && ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.ROUNDED )
-                        && ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE ) && ( tree_panel
-                        .getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR ) ) ) {
-            branch_lengths.setSelected( false );
-            branch_lengths.setEnabled( false );
-        }
-        if ( tree_panel != null ) {
-            if ( ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR )
-                    || ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) ) {
-                non_lined_up.setEnabled( false );
-                uniform_clado.setEnabled( false );
-                nonuniform_clado.setEnabled( false );
-            }
-            else {
-                non_lined_up.setEnabled( true );
-                uniform_clado.setEnabled( true );
-                nonuniform_clado.setEnabled( true );
-            }
-        }
-        else {
-            if ( ( tree_panel != null )
-                    && ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE ) && ( tree_panel
-                            .getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR ) ) ) {
-                branch_lengths.setSelected( false );
-                branch_lengths.setEnabled( false );
-            }
-            if ( ( tree_panel != null )
-                    && ( ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) || ( tree_panel
-                            .getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) ) ) {
-                non_lined_up.setEnabled( false );
-            }
-            else {
-                // non_lined_up.setSelected( options.isNonLinedUpCladogram() );
-                non_lined_up.setEnabled( true );
-            }
-        }
-        label_direction_cbmi.setEnabled( true );
-        if ( tree_panel != null ) {
-            if ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.UNROOTED )
-                    && ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) {
-                label_direction_cbmi.setEnabled( false );
-            }
-            if ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) {
-                scale.setSelected( false );
-                scale.setEnabled( false );
-            }
-        }
-    }
-
-    static void updateScreenTextAntialias( final List<TreePanel> treepanels ) {
-        for( final TreePanel tree_panel : treepanels ) {
-            tree_panel.setTextAntialias();
-        }
-    }
-}
+// $Id:\r
+// FORESTER -- software libraries and applications\r
+// for evolutionary biology research and applications.\r
+//\r
+// Copyright (C) 2008-2010 Christian M. Zmasek\r
+// All rights reserved\r
+//\r
+// This library is free software; you can redistribute it and/or\r
+// modify it under the terms of the GNU Lesser General Public\r
+// License as published by the Free Software Foundation; either\r
+// version 2.1 of the License, or (at your option) any later version.\r
+//\r
+// This library is distributed in the hope that it will be useful,\r
+// but WITHOUT ANY WARRANTY; without even the implied warranty of\r
+// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU\r
+// Lesser General Public License for more details.\r
+//\r
+// You should have received a copy of the GNU Lesser General Public\r
+// License along with this library; if not, write to the Free Software\r
+// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA\r
+//\r
+// Contact: phylosoft @ gmail . com\r
+// WWW: https://sites.google.com/site/cmzmasek/home/software/forester\r
+\r
+package org.forester.archaeopteryx;\r
+\r
+import java.awt.Color;\r
+import java.awt.Component;\r
+import java.awt.Container;\r
+import java.awt.Font;\r
+import java.awt.event.ActionEvent;\r
+import java.awt.event.ActionListener;\r
+import java.io.File;\r
+import java.io.IOException;\r
+import java.util.LinkedList;\r
+import java.util.List;\r
+import java.util.Locale;\r
+import java.util.NoSuchElementException;\r
+import java.util.Set;\r
+\r
+import javax.swing.Box;\r
+import javax.swing.JApplet;\r
+import javax.swing.JCheckBoxMenuItem;\r
+import javax.swing.JFrame;\r
+import javax.swing.JLabel;\r
+import javax.swing.JMenu;\r
+import javax.swing.JMenuBar;\r
+import javax.swing.JMenuItem;\r
+import javax.swing.JOptionPane;\r
+import javax.swing.JPanel;\r
+import javax.swing.JRadioButtonMenuItem;\r
+import javax.swing.JTextField;\r
+import javax.swing.SwingUtilities;\r
+\r
+import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;\r
+import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;\r
+import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;\r
+import org.forester.archaeopteryx.tools.InferenceManager;\r
+import org.forester.archaeopteryx.tools.ProcessPool;\r
+import org.forester.archaeopteryx.tools.ProcessRunning;\r
+import org.forester.io.parsers.nhx.NHXParser.TAXONOMY_EXTRACTION;\r
+import org.forester.phylogeny.Phylogeny;\r
+import org.forester.phylogeny.PhylogenyMethods;\r
+import org.forester.phylogeny.PhylogenyMethods.DESCENDANT_SORT_PRIORITY;\r
+import org.forester.phylogeny.PhylogenyNode;\r
+import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;\r
+import org.forester.phylogeny.data.Annotation;\r
+import org.forester.phylogeny.data.NodeVisualData.NodeFill;\r
+import org.forester.phylogeny.data.NodeVisualData.NodeShape;\r
+import org.forester.sdi.GSDI;\r
+import org.forester.sdi.GSDIR;\r
+import org.forester.sdi.SDIException;\r
+import org.forester.util.ForesterConstants;\r
+import org.forester.util.ForesterUtil;\r
+\r
+public abstract class MainFrame extends JFrame implements ActionListener {\r
+\r
+    static final String         USE_MOUSEWHEEL_SHIFT_TO_ROTATE          = "In this display type, use mousewheel + Shift to rotate [or A and S]";\r
+    static final String         PHYLOXML_REF_TOOL_TIP                   = Constants.PHYLOXML_REFERENCE;                                                                                                                                       //TODO //FIXME\r
+    static final String         APTX_REF_TOOL_TIP                       = Constants.APTX_REFERENCE;\r
+    private static final long   serialVersionUID                        = 3655000897845508358L;\r
+    final static Font           menu_font                               = new Font( Configuration.getDefaultFontFamilyName(),\r
+                                                                                    Font.PLAIN,\r
+                                                                                    10 );\r
+    static final String         TYPE_MENU_HEADER                        = "Type";\r
+    static final String         RECTANGULAR_TYPE_CBMI_LABEL             = "Rectangular";\r
+    static final String         EURO_TYPE_CBMI_LABEL                    = "Euro Type";\r
+    static final String         CURVED_TYPE_CBMI_LABEL                  = "Curved";\r
+    static final String         TRIANGULAR_TYPE_CBMI_LABEL              = "Triangular";\r
+    static final String         CONVEX_TYPE_CBMI_LABEL                  = "Convex";\r
+    static final String         ROUNDED_TYPE_CBMI_LABEL                 = "Rounded";\r
+    static final String         UNROOTED_TYPE_CBMI_LABEL                = "Unrooted (alpha)";                                                                                                                                                 //TODO\r
+    static final String         CIRCULAR_TYPE_CBMI_LABEL                = "Circular (alpha)";                                                                                                                                                 //TODO\r
+    static final String         OPTIONS_HEADER                          = "Options";\r
+    static final String         SEARCH_SUBHEADER                        = "Search:";\r
+    static final String         DISPLAY_SUBHEADER                       = "Display:";\r
+    static final String         SEARCH_TERMS_ONLY_LABEL                 = "Match Complete Terms Only";\r
+    static final String         SEARCH_CASE_SENSITIVE_LABEL             = "Case Sensitive";\r
+    static final String         INVERSE_SEARCH_RESULT_LABEL             = "Negate Result";\r
+    static final String         DISPLAY_BRANCH_LENGTH_VALUES_LABEL      = "Branch Length Values";\r
+    static final String         COLOR_BY_TAXONOMIC_GROUP                = "Colorize by Taxonomic Group";\r
+    static final String         DISPLAY_SCALE_LABEL                     = "Scale";\r
+    static final String         NON_LINED_UP_CLADOGRAMS_LABEL           = "Non-Lined Up Cladograms";\r
+    static final String         UNIFORM_CLADOGRAMS_LABEL                = "Total Node Sum Dependent Cladograms";\r
+    static final String         LABEL_DIRECTION_LABEL                   = "Radial Labels";\r
+    static final String         LABEL_DIRECTION_TIP                     = "To use radial node labels in radial and unrooted display types";\r
+    static final String         SCREEN_ANTIALIAS_LABEL                  = "Antialias";\r
+    static final String         COLOR_LABELS_LABEL                      = "Colorize Labels Same as Parent Branch";\r
+    static final String         BG_GRAD_LABEL                           = "Background Color Gradient";\r
+    static final String         DISPLAY_NODE_BOXES_LABEL_EXT            = "External Node Shapes";\r
+    static final String         DISPLAY_NODE_BOXES_LABEL_INT            = "Internal Node Shapes";\r
+    static final String         SHOW_OVERVIEW_LABEL                     = "Overview";\r
+    static final String         FONT_SIZE_MENU_LABEL                    = "Font Size";\r
+    static final String         NONUNIFORM_CLADOGRAMS_LABEL             = "External Node Sum Dependent Cladograms";\r
+    static final String         SHOW_DOMAIN_LABELS_LABEL                = "Domain Labels";\r
+    static final String         SHOW_ANN_REF_SOURCE_LABEL               = "Seq Annotation Ref Sources";\r
+    static final String         COLOR_LABELS_TIP                        = "To use parent branch colors for node labels as well, need to turn off taxonomy dependent colorization and turn on branch colorization for this to become apparent";\r
+    static final String         ABBREV_SN_LABEL                         = "Abbreviate Scientific Taxonomic Names";\r
+    static final String         TAXONOMY_COLORIZE_NODE_SHAPES_LABEL     = "Colorize Node Shapes According to Taxonomy";\r
+    static final String         CYCLE_NODE_SHAPE_LABEL                  = "Cycle Node Shapes";\r
+    static final String         CYCLE_NODE_FILL_LABEL                   = "Cycle Node Fill Type";\r
+    static final String         CHOOSE_NODE_SIZE_LABEL                  = "Choose Node Shape Size";\r
+    static final String         SHOW_CONF_STDDEV_LABEL                  = "Confidence Standard Deviations";\r
+    static final String         USE_BRACKETS_FOR_CONF_IN_NH_LABEL       = "Use Brackets for Confidence Values";\r
+    static final String         USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL = "Use Internal Node Names for Confidence Values";\r
+    static final String         SHOW_BASIC_TREE_INFORMATION_LABEL       = "Basic Tree Information";\r
+    JMenuBar                    _jmenubar;\r
+    JMenu                       _file_jmenu;\r
+    JMenu                       _tools_menu;\r
+    JMenu                       _view_jmenu;\r
+    JMenu                       _options_jmenu;\r
+    JMenu                       _font_size_menu;\r
+    JMenu                       _help_jmenu;\r
+    JMenuItem[]                 _load_phylogeny_from_webservice_menu_items;\r
+    // Analysis menu\r
+    JMenu                       _analysis_menu;\r
+    JMenuItem                   _load_species_tree_item;\r
+    JMenuItem                   _gsdi_item;\r
+    JMenuItem                   _gsdir_item;\r
+    JMenuItem                   _lineage_inference;\r
+    // file menu:\r
+    JMenuItem                   _open_item;\r
+    JMenuItem                   _open_url_item;\r
+    JMenuItem                   _save_item;\r
+    JMenuItem                   _save_all_item;\r
+    JMenuItem                   _close_item;\r
+    JMenuItem                   _exit_item;\r
+    JMenuItem                   _new_item;\r
+    // tools menu:\r
+    JMenuItem                   _midpoint_root_item;\r
+    JMenuItem                   _taxcolor_item;\r
+    JMenuItem                   _confcolor_item;\r
+    JMenuItem                   _color_rank_jmi;\r
+    JMenuItem                   _collapse_species_specific_subtrees;\r
+    JMenuItem                   _collapse_below_threshold;                                                                                                                                                                                    //TODO implememt me\r
+    JMenuItem                   _obtain_detailed_taxonomic_information_jmi;\r
+    JMenuItem                   _obtain_detailed_taxonomic_information_deleting_jmi;\r
+    JMenuItem                   _obtain_seq_information_jmi;\r
+    JMenuItem                   _move_node_names_to_tax_sn_jmi;\r
+    JMenuItem                   _move_node_names_to_seq_names_jmi;\r
+    JMenuItem                   _extract_tax_code_from_node_names_jmi;\r
+    JMenuItem                   _annotate_item;\r
+    JMenuItem                   _remove_branch_color_item;\r
+    JMenuItem                   _remove_visual_styles_item;\r
+    // font size menu:\r
+    JMenuItem                   _super_tiny_fonts_item;\r
+    JMenuItem                   _tiny_fonts_item;\r
+    JMenuItem                   _small_fonts_item;\r
+    JMenuItem                   _medium_fonts_item;\r
+    JMenuItem                   _large_fonts_item;\r
+    // options menu:\r
+    // _  screen and print\r
+    JMenuItem                   _choose_font_mi;\r
+    JMenuItem                   _switch_colors_mi;\r
+    JCheckBoxMenuItem           _label_direction_cbmi;\r
+    // _  screen display\r
+    JCheckBoxMenuItem           _screen_antialias_cbmi;\r
+    JCheckBoxMenuItem           _background_gradient_cbmi;\r
+    JRadioButtonMenuItem        _non_lined_up_cladograms_rbmi;\r
+    JRadioButtonMenuItem        _uniform_cladograms_rbmi;\r
+    JRadioButtonMenuItem        _ext_node_dependent_cladogram_rbmi;\r
+    JCheckBoxMenuItem           _show_branch_length_values_cbmi;\r
+    JCheckBoxMenuItem           _color_by_taxonomic_group_cbmi;\r
+    JCheckBoxMenuItem           _show_scale_cbmi;                                                                                                                                                                                             //TODO fix me\r
+    JCheckBoxMenuItem           _show_overview_cbmi;\r
+    JCheckBoxMenuItem           _show_domain_labels;\r
+    JCheckBoxMenuItem           _show_annotation_ref_source;\r
+    JCheckBoxMenuItem           _abbreviate_scientific_names;\r
+    JCheckBoxMenuItem           _color_labels_same_as_parent_branch;\r
+    JMenuItem                   _overview_placment_mi;\r
+    JMenuItem                   _choose_minimal_confidence_mi;\r
+    JCheckBoxMenuItem           _show_default_node_shapes_internal_cbmi;\r
+    JCheckBoxMenuItem           _show_default_node_shapes_external_cbmi;\r
+    JMenuItem                   _cycle_node_shape_mi;\r
+    JMenuItem                   _cycle_node_fill_mi;\r
+    JMenuItem                   _choose_node_size_mi;\r
+    JCheckBoxMenuItem           _show_confidence_stddev_cbmi;\r
+    // _  print\r
+    JCheckBoxMenuItem           _graphics_export_visible_only_cbmi;\r
+    JCheckBoxMenuItem           _antialias_print_cbmi;\r
+    JCheckBoxMenuItem           _print_black_and_white_cbmi;\r
+    JCheckBoxMenuItem           _print_using_actual_size_cbmi;\r
+    JCheckBoxMenuItem           _graphics_export_using_actual_size_cbmi;\r
+    JMenuItem                   _print_size_mi;\r
+    JMenuItem                   _choose_pdf_width_mi;\r
+    // _  parsing\r
+    JCheckBoxMenuItem           _internal_number_are_confidence_for_nh_parsing_cbmi;\r
+    JRadioButtonMenuItem        _extract_taxonomy_no_rbmi;\r
+    JRadioButtonMenuItem        _extract_taxonomy_agressive_rbmi;\r
+    JRadioButtonMenuItem        _extract_taxonomy_pfam_strict_rbmi;\r
+    JRadioButtonMenuItem        _extract_taxonomy_pfam_relaxed_rbmi;\r
+    JCheckBoxMenuItem           _replace_underscores_cbmi;\r
+    JCheckBoxMenuItem           _allow_errors_in_distance_to_parent_cbmi;\r
+    JCheckBoxMenuItem           _use_brackets_for_conf_in_nh_export_cbmi;\r
+    JCheckBoxMenuItem           _use_internal_names_for_conf_in_nh_export_cbmi;\r
+    // _  search\r
+    JCheckBoxMenuItem           _search_case_senstive_cbmi;\r
+    JCheckBoxMenuItem           _search_whole_words_only_cbmi;\r
+    JCheckBoxMenuItem           _inverse_search_result_cbmi;\r
+    // type menu:\r
+    JMenu                       _type_menu;\r
+    JCheckBoxMenuItem           _rectangular_type_cbmi;\r
+    JCheckBoxMenuItem           _triangular_type_cbmi;\r
+    JCheckBoxMenuItem           _curved_type_cbmi;\r
+    JCheckBoxMenuItem           _convex_type_cbmi;\r
+    JCheckBoxMenuItem           _euro_type_cbmi;\r
+    JCheckBoxMenuItem           _rounded_type_cbmi;\r
+    JCheckBoxMenuItem           _unrooted_type_cbmi;\r
+    JCheckBoxMenuItem           _circular_type_cbmi;\r
+    // view as text menu:\r
+    JMenuItem                   _view_as_NH_item;\r
+    JMenuItem                   _view_as_XML_item;\r
+    JMenuItem                   _view_as_nexus_item;\r
+    JMenuItem                   _display_basic_information_item;\r
+    // help menu:\r
+    JMenuItem                   _about_item;\r
+    JMenuItem                   _help_item;\r
+    JMenuItem                   _website_item;\r
+    JMenuItem                   _phyloxml_website_item;\r
+    JMenuItem                   _phyloxml_ref_item;\r
+    JMenuItem                   _aptx_ref_item;\r
+    // process menu:\r
+    JMenu                       _process_menu;\r
+    // Handy pointers to child components:\r
+    MainPanel                   _mainpanel;\r
+    Container                   _contentpane;\r
+    final LinkedList<TextFrame> _textframes                             = new LinkedList<TextFrame>();                                                                                                                                         ;\r
+    Configuration               _configuration;\r
+    Options                     _options;\r
+    private Phylogeny           _species_tree;\r
+    InferenceManager            _inference_manager;\r
+    final ProcessPool           _process_pool;\r
+    private String              _previous_node_annotation_ref;\r
+\r
+    MainFrame() {\r
+        _process_pool = ProcessPool.createInstance();\r
+    }\r
+\r
+    /**\r
+     * Action performed.\r
+     */\r
+    @Override\r
+    public void actionPerformed( final ActionEvent e ) {\r
+        final Object o = e.getSource();\r
+        boolean is_applet = false;\r
+        JApplet applet = null;\r
+        if ( getCurrentTreePanel() != null ) {\r
+            is_applet = getCurrentTreePanel().isApplet();\r
+            if ( is_applet ) {\r
+                applet = getCurrentTreePanel().obtainApplet();\r
+            }\r
+        }\r
+        if ( o == _exit_item ) {\r
+            close();\r
+        }\r
+        else if ( o == _gsdi_item ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            executeGSDI();\r
+        }\r
+        else if ( o == _gsdir_item ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            executeGSDIR();\r
+        }\r
+        else if ( o == _taxcolor_item ) {\r
+            taxColor();\r
+        }\r
+        else if ( o == _confcolor_item ) {\r
+            confColor();\r
+        }\r
+        else if ( o == _color_rank_jmi ) {\r
+            colorRank();\r
+        }\r
+        else if ( o == _collapse_species_specific_subtrees ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().collapseSpeciesSpecificSubtrees();\r
+            }\r
+        }\r
+        else if ( o == _remove_branch_color_item ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            removeBranchColors();\r
+        }\r
+        else if ( o == _remove_visual_styles_item ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            removeVisualStyles();\r
+        }\r
+        else if ( o == _midpoint_root_item ) {\r
+            if ( isSubtreeDisplayed() ) {\r
+                return;\r
+            }\r
+            midpointRoot();\r
+        }\r
+        else if ( o == _annotate_item ) {\r
+            annotateSequences();\r
+        }\r
+        else if ( o == _switch_colors_mi ) {\r
+            switchColors();\r
+        }\r
+        else if ( o == _display_basic_information_item ) {\r
+            displayBasicInformation( getCurrentTreePanel().getTreeFile() );\r
+        }\r
+        else if ( o == _view_as_NH_item ) {\r
+            viewAsNH();\r
+        }\r
+        else if ( o == _view_as_XML_item ) {\r
+            viewAsXML();\r
+        }\r
+        else if ( o == _view_as_nexus_item ) {\r
+            viewAsNexus();\r
+        }\r
+        else if ( o == _super_tiny_fonts_item ) {\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().setSuperTinyFonts();\r
+                getCurrentTreePanel().repaint();\r
+            }\r
+        }\r
+        else if ( o == _tiny_fonts_item ) {\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().setTinyFonts();\r
+                getCurrentTreePanel().repaint();\r
+            }\r
+        }\r
+        else if ( o == _small_fonts_item ) {\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().setSmallFonts();\r
+                getCurrentTreePanel().repaint();\r
+            }\r
+        }\r
+        else if ( o == _medium_fonts_item ) {\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().setMediumFonts();\r
+                getCurrentTreePanel().repaint();\r
+            }\r
+        }\r
+        else if ( o == _large_fonts_item ) {\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().setLargeFonts();\r
+                getCurrentTreePanel().repaint();\r
+            }\r
+        }\r
+        else if ( o == _choose_font_mi ) {\r
+            chooseFont();\r
+        }\r
+        else if ( o == _choose_minimal_confidence_mi ) {\r
+            chooseMinimalConfidence();\r
+        }\r
+        else if ( o == _choose_node_size_mi ) {\r
+            chooseNodeSize( getOptions(), this );\r
+        }\r
+        else if ( o == _overview_placment_mi ) {\r
+            MainFrame.cycleOverview( getOptions(), getCurrentTreePanel() );\r
+        }\r
+        else if ( o == _cycle_node_fill_mi ) {\r
+            MainFrame.cycleNodeFill( getOptions(), getCurrentTreePanel() );\r
+        }\r
+        else if ( o == _cycle_node_shape_mi ) {\r
+            MainFrame.cycleNodeShape( getOptions(), getCurrentTreePanel() );\r
+        }\r
+        else if ( o == _screen_antialias_cbmi ) {\r
+            updateOptions( getOptions() );\r
+            updateScreenTextAntialias( getMainPanel().getTreePanels() );\r
+        }\r
+        else if ( o == _background_gradient_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_domain_labels ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_annotation_ref_source ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _abbreviate_scientific_names ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _color_labels_same_as_parent_branch ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_default_node_shapes_internal_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_default_node_shapes_external_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _non_lined_up_cladograms_rbmi ) {\r
+            updateOptions( getOptions() );\r
+            showWhole();\r
+        }\r
+        else if ( o == _uniform_cladograms_rbmi ) {\r
+            updateOptions( getOptions() );\r
+            showWhole();\r
+        }\r
+        else if ( o == _ext_node_dependent_cladogram_rbmi ) {\r
+            updateOptions( getOptions() );\r
+            showWhole();\r
+        }\r
+        else if ( o == _search_case_senstive_cbmi ) {\r
+            updateOptions( getOptions() );\r
+            getMainPanel().getControlPanel().search0();\r
+            getMainPanel().getControlPanel().search1();\r
+        }\r
+        else if ( o == _search_whole_words_only_cbmi ) {\r
+            updateOptions( getOptions() );\r
+            getMainPanel().getControlPanel().search0();\r
+            getMainPanel().getControlPanel().search1();\r
+        }\r
+        else if ( o == _inverse_search_result_cbmi ) {\r
+            updateOptions( getOptions() );\r
+            getMainPanel().getControlPanel().search0();\r
+            getMainPanel().getControlPanel().search1();\r
+        }\r
+        else if ( o == _show_scale_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_branch_length_values_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _color_by_taxonomic_group_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_confidence_stddev_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _use_brackets_for_conf_in_nh_export_cbmi ) {\r
+            if ( _use_brackets_for_conf_in_nh_export_cbmi.isSelected() ) {\r
+                _use_internal_names_for_conf_in_nh_export_cbmi.setSelected( false );\r
+            }\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _use_internal_names_for_conf_in_nh_export_cbmi ) {\r
+            if ( _use_internal_names_for_conf_in_nh_export_cbmi.isSelected() ) {\r
+                _use_brackets_for_conf_in_nh_export_cbmi.setSelected( false );\r
+            }\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _label_direction_cbmi ) {\r
+            updateOptions( getOptions() );\r
+        }\r
+        else if ( o == _show_overview_cbmi ) {\r
+            updateOptions( getOptions() );\r
+            if ( getCurrentTreePanel() != null ) {\r
+                getCurrentTreePanel().updateOvSizes();\r
+            }\r
+        }\r
+        else if ( ( o == _rectangular_type_cbmi ) || ( o == _triangular_type_cbmi ) || ( o == _curved_type_cbmi )\r
+                || ( o == _convex_type_cbmi ) || ( o == _euro_type_cbmi ) || ( o == _rounded_type_cbmi )\r
+                || ( o == _unrooted_type_cbmi ) || ( o == _circular_type_cbmi ) ) {\r
+            typeChanged( o );\r
+        }\r
+        else if ( o == _about_item ) {\r
+            about();\r
+        }\r
+        else if ( o == _help_item ) {\r
+            help();\r
+        }\r
+        else if ( o == _website_item ) {\r
+            try {\r
+                AptxUtil.openWebsite( Constants.APTX_WEB_SITE, is_applet, applet );\r
+            }\r
+            catch ( final IOException e1 ) {\r
+                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );\r
+            }\r
+        }\r
+        else if ( o == _phyloxml_website_item ) {\r
+            try {\r
+                AptxUtil.openWebsite( Constants.PHYLOXML_WEB_SITE, is_applet, applet );\r
+            }\r
+            catch ( final IOException e1 ) {\r
+                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );\r
+            }\r
+        }\r
+        else if ( o == _aptx_ref_item ) {\r
+            try {\r
+                AptxUtil.openWebsite( Constants.APTX_REFERENCE_URL, is_applet, applet );\r
+            }\r
+            catch ( final IOException e1 ) {\r
+                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );\r
+            }\r
+        }\r
+        else if ( o == _phyloxml_ref_item ) {\r
+            try {\r
+                AptxUtil.openWebsite( Constants.PHYLOXML_REFERENCE_URL, is_applet, applet );\r
+            }\r
+            catch ( final IOException e1 ) {\r
+                ForesterUtil.printErrorMessage( Constants.PRG_NAME, e1.toString() );\r
+            }\r
+        }\r
+        else {\r
+            if ( _load_phylogeny_from_webservice_menu_items != null ) {\r
+                for( int i = 0; i < _load_phylogeny_from_webservice_menu_items.length; ++i ) {\r
+                    if ( o == _load_phylogeny_from_webservice_menu_items[ i ] ) {\r
+                        readPhylogeniesFromWebservice( i );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        _contentpane.repaint();\r
+    }\r
+\r
+    public Configuration getConfiguration() {\r
+        return _configuration;\r
+    }\r
+\r
+    /**\r
+     * This method returns the current external node data which\r
+     * has been selected by the user by clicking the "Return ..."\r
+     * menu item. This method is expected to be called from Javascript or\r
+     * something like it.\r
+     * \r
+     * @return current external node data as String\r
+     */\r
+    public String getCurrentExternalNodesDataBuffer() {\r
+        return getCurrentTreePanel().getCurrentExternalNodesDataBufferAsString();\r
+    }\r
+\r
+    public int getCurrentExternalNodesDataBufferChangeCounter() {\r
+        return getCurrentTreePanel().getCurrentExternalNodesDataBufferChangeCounter();\r
+    }\r
+\r
+    public int getCurrentExternalNodesDataBufferLength() {\r
+        return getCurrentTreePanel().getCurrentExternalNodesDataBufferAsString().length();\r
+    }\r
+\r
+    public InferenceManager getInferenceManager() {\r
+        return _inference_manager;\r
+    }\r
+\r
+    public MainPanel getMainPanel() {\r
+        return _mainpanel;\r
+    }\r
+\r
+    public Options getOptions() {\r
+        return _options;\r
+    }\r
+\r
+    public ProcessPool getProcessPool() {\r
+        return _process_pool;\r
+    }\r
+\r
+    public void showTextFrame( final String s, final String title ) {\r
+        checkTextFrames();\r
+        _textframes.addLast( TextFrame.instantiate( s, title, _textframes ) );\r
+    }\r
+\r
+    public void showWhole() {\r
+        _mainpanel.getControlPanel().showWhole();\r
+    }\r
+\r
+    public void updateProcessMenu() {\r
+        // In general Swing is not thread safe.\r
+        // See "Swing's Threading Policy".\r
+        SwingUtilities.invokeLater( new Runnable() {\r
+\r
+            @Override\r
+            public void run() {\r
+                doUpdateProcessMenu();\r
+            }\r
+        } );\r
+    }\r
+\r
+    void activateSaveAllIfNeeded() {\r
+        if ( ( getMainPanel().getTabbedPane() != null ) && ( getMainPanel().getTabbedPane().getTabCount() > 1 ) ) {\r
+            _save_all_item.setEnabled( true );\r
+        }\r
+        else {\r
+            _save_all_item.setEnabled( false );\r
+        }\r
+    }\r
+\r
+    void buildFileMenu() {\r
+        _file_jmenu = createMenu( "File", getConfiguration() );\r
+        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );\r
+        customizeJMenuItem( _exit_item );\r
+        _jmenubar.add( _file_jmenu );\r
+    }\r
+\r
+    void buildFontSizeMenu() {\r
+        _font_size_menu = createMenu( FONT_SIZE_MENU_LABEL, getConfiguration() );\r
+        _font_size_menu.add( _super_tiny_fonts_item = new JMenuItem( "Super Tiny Fonts" ) );\r
+        _font_size_menu.add( _tiny_fonts_item = new JMenuItem( "Tiny Fonts" ) );\r
+        _font_size_menu.add( _small_fonts_item = new JMenuItem( "Small Fonts" ) );\r
+        _font_size_menu.add( _medium_fonts_item = new JMenuItem( "Medium Fonts" ) );\r
+        _font_size_menu.add( _large_fonts_item = new JMenuItem( "Large Fonts" ) );\r
+        customizeJMenuItem( _super_tiny_fonts_item );\r
+        customizeJMenuItem( _tiny_fonts_item );\r
+        customizeJMenuItem( _small_fonts_item );\r
+        customizeJMenuItem( _medium_fonts_item );\r
+        customizeJMenuItem( _large_fonts_item );\r
+        _jmenubar.add( _font_size_menu );\r
+    }\r
+\r
+    void buildHelpMenu() {\r
+        _help_jmenu = createMenu( "Help", getConfiguration() );\r
+        _help_jmenu.add( _help_item = new JMenuItem( "Help" ) );\r
+        _help_jmenu.add( _website_item = new JMenuItem( "Archaeopteryx Home" ) );\r
+        _aptx_ref_item = new JMenuItem( "Archaeopteryx Reference" );\r
+        _help_jmenu.add( _phyloxml_website_item = new JMenuItem( "phyloXML Home" ) );\r
+        _help_jmenu.add( _phyloxml_ref_item = new JMenuItem( "phyloXML Reference" ) );\r
+        _help_jmenu.addSeparator();\r
+        _help_jmenu.add( _about_item = new JMenuItem( "About" ) );\r
+        customizeJMenuItem( _help_item );\r
+        customizeJMenuItem( _website_item );\r
+        customizeJMenuItem( _phyloxml_website_item );\r
+        customizeJMenuItem( _aptx_ref_item );\r
+        customizeJMenuItem( _phyloxml_ref_item );\r
+        customizeJMenuItem( _about_item );\r
+        _phyloxml_ref_item.setToolTipText( PHYLOXML_REF_TOOL_TIP );\r
+        _aptx_ref_item.setToolTipText( APTX_REF_TOOL_TIP );\r
+        _jmenubar.add( _help_jmenu );\r
+    }\r
+\r
+    void buildTypeMenu() {\r
+        _type_menu = createMenu( TYPE_MENU_HEADER, getConfiguration() );\r
+        _type_menu.add( _rectangular_type_cbmi = new JCheckBoxMenuItem( MainFrame.RECTANGULAR_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _euro_type_cbmi = new JCheckBoxMenuItem( MainFrame.EURO_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _rounded_type_cbmi = new JCheckBoxMenuItem( MainFrame.ROUNDED_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _curved_type_cbmi = new JCheckBoxMenuItem( MainFrame.CURVED_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _triangular_type_cbmi = new JCheckBoxMenuItem( MainFrame.TRIANGULAR_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _convex_type_cbmi = new JCheckBoxMenuItem( MainFrame.CONVEX_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _unrooted_type_cbmi = new JCheckBoxMenuItem( MainFrame.UNROOTED_TYPE_CBMI_LABEL ) );\r
+        _type_menu.add( _circular_type_cbmi = new JCheckBoxMenuItem( MainFrame.CIRCULAR_TYPE_CBMI_LABEL ) );\r
+        customizeCheckBoxMenuItem( _rectangular_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _triangular_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _euro_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _rounded_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _curved_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _convex_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _unrooted_type_cbmi, false );\r
+        customizeCheckBoxMenuItem( _circular_type_cbmi, false );\r
+        _unrooted_type_cbmi.setToolTipText( MainFrame.USE_MOUSEWHEEL_SHIFT_TO_ROTATE );\r
+        _circular_type_cbmi.setToolTipText( MainFrame.USE_MOUSEWHEEL_SHIFT_TO_ROTATE );\r
+        initializeTypeMenu( getOptions() );\r
+        _jmenubar.add( _type_menu );\r
+    }\r
+\r
+    void buildViewMenu() {\r
+        _view_jmenu = createMenu( "View", getConfiguration() );\r
+        _view_jmenu.add( _display_basic_information_item = new JMenuItem( SHOW_BASIC_TREE_INFORMATION_LABEL ) );\r
+        _view_jmenu.addSeparator();\r
+        _view_jmenu.add( _view_as_XML_item = new JMenuItem( "as phyloXML" ) );\r
+        _view_jmenu.add( _view_as_NH_item = new JMenuItem( "as Newick" ) );\r
+        _view_jmenu.add( _view_as_nexus_item = new JMenuItem( "as Nexus" ) );\r
+        customizeJMenuItem( _display_basic_information_item );\r
+        customizeJMenuItem( _view_as_NH_item );\r
+        customizeJMenuItem( _view_as_XML_item );\r
+        customizeJMenuItem( _view_as_nexus_item );\r
+        _jmenubar.add( _view_jmenu );\r
+    }\r
+\r
+    void checkTextFrames() {\r
+        if ( _textframes.size() > 5 ) {\r
+            try {\r
+                if ( _textframes.getFirst() != null ) {\r
+                    _textframes.getFirst().removeMe();\r
+                }\r
+                else {\r
+                    _textframes.removeFirst();\r
+                }\r
+            }\r
+            catch ( final NoSuchElementException e ) {\r
+                // Ignore.\r
+            }\r
+        }\r
+    }\r
+\r
+    void close() {\r
+        removeAllTextFrames();\r
+        if ( _mainpanel != null ) {\r
+            _mainpanel.terminate();\r
+        }\r
+        if ( _contentpane != null ) {\r
+            _contentpane.removeAll();\r
+        }\r
+        setVisible( false );\r
+        dispose();\r
+    }\r
+\r
+    void colorRank() {\r
+        if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+            final String[] ranks = AptxUtil.getAllPossibleRanks();\r
+            final String rank = ( String ) JOptionPane\r
+                    .showInputDialog( this,\r
+                                      "What rank should the colorization be based on",\r
+                                      "Rank Selection",\r
+                                      JOptionPane.QUESTION_MESSAGE,\r
+                                      null,\r
+                                      ranks,\r
+                                      null );\r
+            if ( !ForesterUtil.isEmpty( rank ) ) {\r
+                _mainpanel.getCurrentTreePanel().colorRank( rank );\r
+            }\r
+        }\r
+    }\r
+\r
+    void confColor() {\r
+        if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+            _mainpanel.getCurrentTreePanel().confColor();\r
+        }\r
+    }\r
+\r
+    void customizeCheckBoxMenuItem( final JCheckBoxMenuItem item, final boolean is_selected ) {\r
+        if ( item != null ) {\r
+            item.setFont( MainFrame.menu_font );\r
+            if ( !getConfiguration().isUseNativeUI() ) {\r
+                item.setBackground( getConfiguration().getGuiMenuBackgroundColor() );\r
+                item.setForeground( getConfiguration().getGuiMenuTextColor() );\r
+            }\r
+            item.setSelected( is_selected );\r
+            item.addActionListener( this );\r
+        }\r
+    }\r
+\r
+    JMenuItem customizeJMenuItem( final JMenuItem jmi ) {\r
+        if ( jmi != null ) {\r
+            jmi.setFont( MainFrame.menu_font );\r
+            if ( !getConfiguration().isUseNativeUI() ) {\r
+                jmi.setBackground( getConfiguration().getGuiMenuBackgroundColor() );\r
+                jmi.setForeground( getConfiguration().getGuiMenuTextColor() );\r
+            }\r
+            jmi.addActionListener( this );\r
+        }\r
+        return jmi;\r
+    }\r
+\r
+    void customizeRadioButtonMenuItem( final JRadioButtonMenuItem item, final boolean is_selected ) {\r
+        if ( item != null ) {\r
+            item.setFont( MainFrame.menu_font );\r
+            if ( !getConfiguration().isUseNativeUI() ) {\r
+                item.setBackground( getConfiguration().getGuiMenuBackgroundColor() );\r
+                item.setForeground( getConfiguration().getGuiMenuTextColor() );\r
+            }\r
+            item.setSelected( is_selected );\r
+            item.addActionListener( this );\r
+        }\r
+    }\r
+\r
+    void displayBasicInformation( final File treefile ) {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {\r
+            String title = "Basic Information";\r
+            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {\r
+                title = title + " for \"" + _mainpanel.getCurrentPhylogeny().getName() + "\"";\r
+            }\r
+            showTextFrame( AptxUtil.createBasicInformation( _mainpanel.getCurrentPhylogeny(), treefile ), title );\r
+        }\r
+    }\r
+\r
+    void exceptionOccuredDuringOpenFile( final Exception e ) {\r
+        try {\r
+            _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+        }\r
+        catch ( final Exception ex ) {\r
+            // Do nothing.\r
+        }\r
+        JOptionPane.showMessageDialog( this,\r
+                                       ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
+                                       "Error during File|Open",\r
+                                       JOptionPane.ERROR_MESSAGE );\r
+    }\r
+\r
+    void exceptionOccuredDuringSaveAs( final Exception e ) {\r
+        try {\r
+            _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+        }\r
+        catch ( final Exception ex ) {\r
+            // Do nothing.\r
+        }\r
+        JOptionPane.showMessageDialog( this, "Exception" + e, "Error during File|SaveAs", JOptionPane.ERROR_MESSAGE );\r
+    }\r
+\r
+    void executeGSDI() {\r
+        if ( !isOKforSDI( false, true ) ) {\r
+            return;\r
+        }\r
+        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Gene tree is not rooted.",\r
+                                           "Cannot execute GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        final Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();\r
+        gene_tree.setAllNodesToNotCollapse();\r
+        gene_tree.recalculateNumberOfExternalDescendants( false );\r
+        GSDI gsdi = null;\r
+        final Phylogeny species_tree = getSpeciesTree().copy();\r
+        try {\r
+            gsdi = new GSDI( gene_tree, species_tree, false, true, true, true );\r
+        }\r
+        catch ( final SDIException e ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           e.getLocalizedMessage(),\r
+                                           "Error during GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        catch ( final Exception e ) {\r
+            AptxUtil.unexpectedException( e );\r
+            return;\r
+        }\r
+        gene_tree.setRerootable( false );\r
+        gene_tree.clearHashIdToNodeMap();\r
+        gene_tree.recalculateNumberOfExternalDescendants( true );\r
+        _mainpanel.addPhylogenyInNewTab( gene_tree, getConfiguration(), "gene tree", null );\r
+        getMainPanel().getControlPanel().setShowEvents( true );\r
+        showWhole();\r
+        final int selected = _mainpanel.getTabbedPane().getSelectedIndex();\r
+        _mainpanel.addPhylogenyInNewTab( species_tree, getConfiguration(), "species tree", null );\r
+        showWhole();\r
+        _mainpanel.getTabbedPane().setSelectedIndex( selected );\r
+        showWhole();\r
+        _mainpanel.getCurrentTreePanel().setEdited( true );\r
+        final int poly = PhylogenyMethods.countNumberOfPolytomies( species_tree );\r
+        if ( gsdi.getStrippedExternalGeneTreeNodes().size() > 0 ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Duplications: " + gsdi.getDuplicationsSum() + "\n"\r
+                                                   + "Potential duplications: "\r
+                                                   + gsdi.getSpeciationOrDuplicationEventsSum() + "\n"\r
+                                                   + "Speciations: " + gsdi.getSpeciationsSum() + "\n"\r
+                                                   + "Stripped gene tree nodes: "\r
+                                                   + gsdi.getStrippedExternalGeneTreeNodes().size() + "\n"\r
+                                                   + "Taxonomy linkage based on: " + gsdi.getTaxCompBase() + "\n"\r
+                                                   + "Number of polytomies in species tree used: " + poly + "\n",\r
+                                           "GSDI successfully completed",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+        }\r
+        else {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Duplications: " + gsdi.getDuplicationsSum() + "\n"\r
+                                                   + "Potential duplications: "\r
+                                                   + gsdi.getSpeciationOrDuplicationEventsSum() + "\n"\r
+                                                   + "Speciations: " + gsdi.getSpeciationsSum() + "\n"\r
+                                                   + "Stripped gene tree nodes: "\r
+                                                   + gsdi.getStrippedExternalGeneTreeNodes().size() + "\n"\r
+                                                   + "Taxonomy linkage based on: " + gsdi.getTaxCompBase() + "\n"\r
+                                                   + "Number of polytomies in species tree used: " + poly + "\n",\r
+                                           "GSDI successfully completed",\r
+                                           JOptionPane.INFORMATION_MESSAGE );\r
+        }\r
+    }\r
+\r
+    void executeGSDIR() {\r
+        if ( !isOKforSDI( false, false ) ) {\r
+            return;\r
+        }\r
+        final int p = PhylogenyMethods.countNumberOfPolytomies( _mainpanel.getCurrentPhylogeny() );\r
+        if ( ( p > 0 )\r
+                && !( ( p == 1 ) && ( _mainpanel.getCurrentPhylogeny().getRoot().getNumberOfDescendants() == 3 ) ) ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Gene tree is not completely binary",\r
+                                           "Cannot execute GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        final Phylogeny gene_tree = _mainpanel.getCurrentPhylogeny().copy();\r
+        gene_tree.setAllNodesToNotCollapse();\r
+        gene_tree.recalculateNumberOfExternalDescendants( false );\r
+        GSDIR gsdir = null;\r
+        final Phylogeny species_tree = getSpeciesTree().copy();\r
+        try {\r
+            gsdir = new GSDIR( gene_tree, species_tree, true, true, true );\r
+        }\r
+        catch ( final SDIException e ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           e.getLocalizedMessage(),\r
+                                           "Error during GSDIR",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        catch ( final Exception e ) {\r
+            AptxUtil.unexpectedException( e );\r
+            return;\r
+        }\r
+        final Phylogeny result_gene_tree = gsdir.getMinDuplicationsSumGeneTree();\r
+        result_gene_tree.setRerootable( false );\r
+        result_gene_tree.clearHashIdToNodeMap();\r
+        result_gene_tree.recalculateNumberOfExternalDescendants( true );\r
+        PhylogenyMethods.orderAppearance( result_gene_tree.getRoot(), true, true, DESCENDANT_SORT_PRIORITY.NODE_NAME );\r
+        _mainpanel.addPhylogenyInNewTab( result_gene_tree, getConfiguration(), "gene tree", null );\r
+        getMainPanel().getControlPanel().setShowEvents( true );\r
+        showWhole();\r
+        final int selected = _mainpanel.getTabbedPane().getSelectedIndex();\r
+        _mainpanel.addPhylogenyInNewTab( species_tree, getConfiguration(), "species tree", null );\r
+        showWhole();\r
+        _mainpanel.getTabbedPane().setSelectedIndex( selected );\r
+        showWhole();\r
+        _mainpanel.getCurrentTreePanel().setEdited( true );\r
+        final int poly = PhylogenyMethods.countNumberOfPolytomies( species_tree );\r
+        if ( gsdir.getStrippedExternalGeneTreeNodes().size() > 0 ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Minimal duplications: " + gsdir.getMinDuplicationsSum() + "\n"\r
+                                                   + "Speciations: " + gsdir.getSpeciationsSum() + "\n"\r
+                                                   + "Stripped gene tree nodes: "\r
+                                                   + gsdir.getStrippedExternalGeneTreeNodes().size() + "\n"\r
+                                                   + "Taxonomy linkage based on: " + gsdir.getTaxCompBase() + "\n"\r
+                                                   + "Number of polytomies in species tree used: " + poly + "\n",\r
+                                           "GSDIR successfully completed",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+        }\r
+        else {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Minimal duplications: " + gsdir.getMinDuplicationsSum() + "\n"\r
+                                                   + "Speciations: " + gsdir.getSpeciationsSum() + "\n"\r
+                                                   + "Stripped gene tree nodes: "\r
+                                                   + gsdir.getStrippedExternalGeneTreeNodes().size() + "\n"\r
+                                                   + "Taxonomy linkage based on: " + gsdir.getTaxCompBase() + "\n"\r
+                                                   + "Number of polytomies in species tree used: " + poly + "\n",\r
+                                           "GSDIR successfully completed",\r
+                                           JOptionPane.INFORMATION_MESSAGE );\r
+        }\r
+    }\r
+\r
+    boolean GAndSDoHaveMoreThanOneSpeciesInComman( final Phylogeny gene_tree ) {\r
+        if ( ( gene_tree == null ) || gene_tree.isEmpty() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Gene tree and species tree have no species in common.",\r
+                                           "Error during SDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return false;\r
+        }\r
+        else if ( gene_tree.getNumberOfExternalNodes() < 2 ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Gene tree and species tree have only one species in common.",\r
+                                           "Error during SDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return false;\r
+        }\r
+        else {\r
+            return true;\r
+        }\r
+    }\r
+\r
+    TreePanel getCurrentTreePanel() {\r
+        return getMainPanel().getCurrentTreePanel();\r
+    }\r
+\r
+    JMenu getHelpMenu() {\r
+        return _help_jmenu;\r
+    }\r
+\r
+    JCheckBoxMenuItem getlabelDirectionCbmi() {\r
+        return _label_direction_cbmi;\r
+    }\r
+\r
+    JMenuBar getMenuBarOfMainFrame() {\r
+        return _jmenubar;\r
+    }\r
+\r
+    final Phylogeny getSpeciesTree() {\r
+        return _species_tree;\r
+    }\r
+\r
+    void help() {\r
+        final StringBuilder sb = new StringBuilder();\r
+        sb.append( "Display options\n" );\r
+        sb.append( "-------------------\n" );\r
+        sb.append( "Use the checkboxes to select types of information to display on the tree.\n\n" );\r
+        sb.append( "Clickable tree nodes\n" );\r
+        sb.append( "--------------------\n" );\r
+        sb.append( "Tree nodes can be clicked, the action is determined by the 'click on node to' menu\n" );\r
+        sb.append( "or by right clicking:\n" );\r
+        sb.append( "o  Display Node Data -- display information for a node\n" );\r
+        sb.append( "o  Collapse/Uncollapse -- collapse and uncollapse subtree from clicked node\n" );\r
+        sb.append( "o  Root/Reroot -- change tree root to clicked node\n" );\r
+        sb.append( "o  Sub/Super Tree -- toggle between subtree from clicked node and whole tree\n" );\r
+        sb.append( "o  Swap Descendants -- switch descendant on either side of clicked node\n" );\r
+        sb.append( "o  Colorize Subtree -- color a subtree\n" );\r
+        sb.append( "o  Open Sequence Web -- launch a web browser to display sequence information\n" );\r
+        sb.append( "o  Open Taxonomy Web -- launch a web browser to display taxonomy information\n" );\r
+        sb.append( "-  there may be additional choices depending on this particular setup\n\n" );\r
+        sb.append( "Right clicking on a node always displays the information of a node.\n\n" );\r
+        sb.append( "Zooming\n" );\r
+        sb.append( "---------\n" );\r
+        sb.append( "The mouse wheel and the plus and minus keys control zooming.\n" );\r
+        sb.append( "Mouse wheel+Ctrl changes the text size.\n" );\r
+        sb.append( "Mouse wheel+Shift controls zooming in vertical direction only.\n" );\r
+        sb.append( "Use the buttons on the control panel to zoom the tree in and out, horizontally or vertically.\n" );\r
+        sb.append( "The entire tree can be fitted into the window by clicking the \"F\" button, or by pressing F, Delete, or Home.\n" );\r
+        sb.append( "The up, down, left, and right keys can be used to move the visible part (if zoomed in).\n" );\r
+        sb.append( "Up, down, left, and right+Shift can be used to control zooming horizontally and vertically.\n" );\r
+        sb.append( "Plus and minus keys+Ctrl change the text size; F+Ctrl, Delete+Ctrl, or Home+Ctrl resets it.\n\n" );\r
+        sb.append( "Quick tree manipulation:\n" );\r
+        sb.append( "------------------------\n" );\r
+        sb.append( "Order Subtrees -- order the tree by branch length\n" );\r
+        sb.append( "Uncollapse All -- uncollapse any and all collapsed branches\n\n" );\r
+        sb.append( "Memory problems (Java heap space error)\n" );\r
+        sb.append( "---------------------------------------\n" );\r
+        sb.append( "Since the Java default memory allocation is quite small, it might by necessary (for trees\n" );\r
+        sb.append( "with more than approximately 5000 external nodes) to increase the memory which Java can use, with\n" );\r
+        sb.append( "the '-Xmx' Java command line option. For example:\n" );\r
+        sb.append( "java -Xmx1024m -cp path\\to\\forester.jar org.forester.archaeopteryx.Archaeopteryx\n\n" );\r
+        // + "General remarks\n"\r
+        // + "---------------\n"\r
+        // +\r
+        // "o  The application version permits copying to the clipboard \n"\r
+        // +\r
+        // "    in the \"View\"|\"View as ...\" frame (either by control-c or button press).\n"\r
+        // +\r
+        // "o  Changes made to a subtree affect this subtree and its subtrees,\n"\r
+        // + "    but not any of its parent tree(s).\n"\r
+        // +\r
+        // "o  Archaeopteryx tries to detect whether the numerical values in a NH tree\n"\r
+        // +\r
+        // "    are likely to be bootstrap values instead of branch length values.\n\n"\r
+        // +\r
+        // " Remarks regarding SDI (Speciation Duplication Inference):\n"\r
+        // +\r
+        // "o  Each external node of the gene tree (in display) needs to be associated with\n"\r
+        // +\r
+        // "    a species: either directly through the \"Species\" field, or the species\n"\r
+        // +\r
+        // "    is part of the sequence name in the form \"XXXX_SPECIES\"\n"\r
+        // +\r
+        // "    (e.g. \"ACON_DROME\" or \"ACON_DROME/123-4489\" which is also acceptable).\n"\r
+        // +\r
+        // "o  A species tree for each species of the gene tree needs to be loaded with\n"\r
+        // +\r
+        // "   \"SDI\"|\"Load species tree\" prior the SDI execution.\n"\r
+        // +\r
+        // "o  !External nodes of the gene tree associated with species not present in\n"\r
+        // +\r
+        // "    the species tree are REMOVED prior to SDI execution!\n"\r
+        // +\r
+        // "o  Both the gene tree and the species tree must be completely binary.\n"\r
+        // +\r
+        // "o  Duplications and speciations are a function of the position of the root.\n"\r
+        // +\r
+        // "    Hence, after each manual \"Root/Reroot\"ing some duplications will be\n"\r
+        // + "    incorrect and need to be inferred again\n"\r
+        // +\r
+        // "    with: \"SDI\"|\"SDI (Speciation Duplication Inference)\n\n"\r
+        sb.append( "phyloXML\n" );\r
+        sb.append( "-------------------\n" );\r
+        sb.append( "Reference: " + Constants.PHYLOXML_REFERENCE + "\n" );\r
+        sb.append( "Website: " + Constants.PHYLOXML_WEB_SITE + "\n" );\r
+        sb.append( "Version: " + ForesterConstants.PHYLO_XML_VERSION + "\n" );\r
+        sb.append( "\n" );\r
+        sb.append( "For more information: https://sites.google.com/site/cmzmasek/home/software/archaeopteryx\n" );\r
+        sb.append( "Email: " + Constants.AUTHOR_EMAIL + "\n\n" );\r
+        TextFrame.instantiate( sb.toString(), "Help", _textframes );\r
+    }\r
+\r
+    void initializeTypeMenu( final Options options ) {\r
+        setTypeMenuToAllUnselected();\r
+        switch ( options.getPhylogenyGraphicsType() ) {\r
+            case CONVEX:\r
+                _convex_type_cbmi.setSelected( true );\r
+                break;\r
+            case CURVED:\r
+                _curved_type_cbmi.setSelected( true );\r
+                break;\r
+            case EURO_STYLE:\r
+                _euro_type_cbmi.setSelected( true );\r
+                break;\r
+            case ROUNDED:\r
+                _rounded_type_cbmi.setSelected( true );\r
+                break;\r
+            case TRIANGULAR:\r
+                _triangular_type_cbmi.setSelected( true );\r
+                break;\r
+            case UNROOTED:\r
+                _unrooted_type_cbmi.setSelected( true );\r
+                break;\r
+            case CIRCULAR:\r
+                _circular_type_cbmi.setSelected( true );\r
+                break;\r
+            default:\r
+                _rectangular_type_cbmi.setSelected( true );\r
+                break;\r
+        }\r
+    }\r
+\r
+    boolean isOKforSDI( final boolean species_tree_has_to_binary, final boolean gene_tree_has_to_binary ) {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || _mainpanel.getCurrentPhylogeny().isEmpty() ) {\r
+            return false;\r
+        }\r
+        else if ( ( getSpeciesTree() == null ) || getSpeciesTree().isEmpty() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "No species tree loaded",\r
+                                           "Cannot execute GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return false;\r
+        }\r
+        else if ( species_tree_has_to_binary && !getSpeciesTree().isCompletelyBinary() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Species tree is not completely binary",\r
+                                           "Cannot execute GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return false;\r
+        }\r
+        else if ( gene_tree_has_to_binary && !_mainpanel.getCurrentPhylogeny().isCompletelyBinary() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Gene tree is not completely binary",\r
+                                           "Cannot execute GSDI",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return false;\r
+        }\r
+        else {\r
+            return true;\r
+        }\r
+    }\r
+\r
+    boolean isSubtreeDisplayed() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            if ( getCurrentTreePanel().isCurrentTreeIsSubtree() ) {\r
+                JOptionPane\r
+                        .showMessageDialog( this,\r
+                                            "This operation can only be performed on a complete tree, not on the currently displayed sub-tree only.",\r
+                                            "Operation can not be exectuted on a sub-tree",\r
+                                            JOptionPane.WARNING_MESSAGE );\r
+                return true;\r
+            }\r
+        }\r
+        return false;\r
+    }\r
+\r
+    void midpointRoot() {\r
+        if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+            _mainpanel.getCurrentTreePanel().midpointRoot();\r
+        }\r
+    }\r
+\r
+    void readPhylogeniesFromWebservice( final int i ) {\r
+        final UrlTreeReader reader = new UrlTreeReader( this, i );\r
+        new Thread( reader ).start();\r
+    }\r
+\r
+    void removeAllTextFrames() {\r
+        for( final TextFrame tf : _textframes ) {\r
+            if ( tf != null ) {\r
+                tf.close();\r
+            }\r
+        }\r
+        _textframes.clear();\r
+    }\r
+\r
+    void setConfiguration( final Configuration configuration ) {\r
+        _configuration = configuration;\r
+    }\r
+\r
+    void setInferenceManager( final InferenceManager i ) {\r
+        _inference_manager = i;\r
+    }\r
+\r
+    void setOptions( final Options options ) {\r
+        _options = options;\r
+    }\r
+\r
+    void setSelectedTypeInTypeMenu( final PHYLOGENY_GRAPHICS_TYPE type ) {\r
+        setTypeMenuToAllUnselected();\r
+        switch ( type ) {\r
+            case CIRCULAR:\r
+                _circular_type_cbmi.setSelected( true );\r
+                break;\r
+            case CONVEX:\r
+                _convex_type_cbmi.setSelected( true );\r
+                break;\r
+            case CURVED:\r
+                _curved_type_cbmi.setSelected( true );\r
+                break;\r
+            case EURO_STYLE:\r
+                _euro_type_cbmi.setSelected( true );\r
+                break;\r
+            case ROUNDED:\r
+                _rounded_type_cbmi.setSelected( true );\r
+                break;\r
+            case RECTANGULAR:\r
+                _rectangular_type_cbmi.setSelected( true );\r
+                break;\r
+            case TRIANGULAR:\r
+                _triangular_type_cbmi.setSelected( true );\r
+                break;\r
+            case UNROOTED:\r
+                _unrooted_type_cbmi.setSelected( true );\r
+                break;\r
+            default:\r
+                throw new IllegalArgumentException( "unknown type: " + type );\r
+        }\r
+    }\r
+\r
+    final void setSpeciesTree( final Phylogeny species_tree ) {\r
+        _species_tree = species_tree;\r
+    }\r
+\r
+    void setTypeMenuToAllUnselected() {\r
+        _convex_type_cbmi.setSelected( false );\r
+        _curved_type_cbmi.setSelected( false );\r
+        _euro_type_cbmi.setSelected( false );\r
+        _rounded_type_cbmi.setSelected( false );\r
+        _triangular_type_cbmi.setSelected( false );\r
+        _rectangular_type_cbmi.setSelected( false );\r
+        _unrooted_type_cbmi.setSelected( false );\r
+        _circular_type_cbmi.setSelected( false );\r
+    }\r
+\r
+    void switchColors() {\r
+        final TreeColorSet colorset = _mainpanel.getTreeColorSet();\r
+        final ColorSchemeChooser csc = new ColorSchemeChooser( getMainPanel(), colorset );\r
+        csc.setVisible( true );\r
+    }\r
+\r
+    void taxColor() {\r
+        if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+            _mainpanel.getCurrentTreePanel().taxColor();\r
+        }\r
+    }\r
+\r
+    void typeChanged( final Object o ) {\r
+        updateTypeCheckboxes( getOptions(), o );\r
+        updateOptions( getOptions() );\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final PHYLOGENY_GRAPHICS_TYPE previous_type = getCurrentTreePanel().getPhylogenyGraphicsType();\r
+            final PHYLOGENY_GRAPHICS_TYPE new_type = getOptions().getPhylogenyGraphicsType();\r
+            if ( ( ( previous_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) && ( new_type != PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) )\r
+                    || ( ( previous_type == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) && ( new_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) )\r
+                    || ( ( previous_type != PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) && ( new_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) )\r
+                    || ( ( previous_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) && ( new_type == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) ) {\r
+                getCurrentTreePanel().getControlPanel().showWhole();\r
+            }\r
+            if ( getCurrentTreePanel().isPhyHasBranchLengths() && ( new_type != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) {\r
+                getCurrentTreePanel().getControlPanel().setDrawPhylogramEnabled( true );\r
+            }\r
+            else {\r
+                getCurrentTreePanel().getControlPanel().setDrawPhylogramEnabled( false );\r
+            }\r
+            getCurrentTreePanel().setPhylogenyGraphicsType( getOptions().getPhylogenyGraphicsType() );\r
+            updateScreenTextAntialias( getMainPanel().getTreePanels() );\r
+            if ( getCurrentTreePanel().getControlPanel().getDynamicallyHideData() != null ) {\r
+                if ( new_type == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) {\r
+                    getCurrentTreePanel().getControlPanel().getDynamicallyHideData().setEnabled( false );\r
+                }\r
+                else {\r
+                    getCurrentTreePanel().getControlPanel().getDynamicallyHideData().setEnabled( true );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    void updateOptions( final Options options ) {\r
+        options.setAntialiasScreen( ( _screen_antialias_cbmi != null ) && _screen_antialias_cbmi.isSelected() );\r
+        options.setBackgroundColorGradient( ( _background_gradient_cbmi != null )\r
+                && _background_gradient_cbmi.isSelected() );\r
+        options.setShowDomainLabels( ( _show_domain_labels != null ) && _show_domain_labels.isSelected() );\r
+        options.setShowAnnotationRefSource( ( _show_annotation_ref_source != null )\r
+                && _show_annotation_ref_source.isSelected() );\r
+        options.setAbbreviateScientificTaxonNames( ( _abbreviate_scientific_names != null )\r
+                && _abbreviate_scientific_names.isSelected() );\r
+        options.setColorLabelsSameAsParentBranch( ( _color_labels_same_as_parent_branch != null )\r
+                && _color_labels_same_as_parent_branch.isSelected() );\r
+        options.setShowDefaultNodeShapesInternal( ( _show_default_node_shapes_internal_cbmi != null )\r
+                && _show_default_node_shapes_internal_cbmi.isSelected() );\r
+        options.setShowDefaultNodeShapesExternal( ( _show_default_node_shapes_external_cbmi != null )\r
+                && _show_default_node_shapes_external_cbmi.isSelected() );\r
+        if ( ( _non_lined_up_cladograms_rbmi != null ) && ( _non_lined_up_cladograms_rbmi.isSelected() ) ) {\r
+            options.setCladogramType( CLADOGRAM_TYPE.NON_LINED_UP );\r
+        }\r
+        else if ( ( _uniform_cladograms_rbmi != null ) && ( _uniform_cladograms_rbmi.isSelected() ) ) {\r
+            options.setCladogramType( CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );\r
+        }\r
+        else if ( ( _ext_node_dependent_cladogram_rbmi != null ) && ( _ext_node_dependent_cladogram_rbmi.isSelected() ) ) {\r
+            options.setCladogramType( CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );\r
+        }\r
+        options.setSearchCaseSensitive( ( _search_case_senstive_cbmi != null )\r
+                && _search_case_senstive_cbmi.isSelected() );\r
+        if ( ( _show_scale_cbmi != null ) && _show_scale_cbmi.isEnabled() ) {\r
+            options.setShowScale( _show_scale_cbmi.isSelected() );\r
+        }\r
+        if ( _label_direction_cbmi != null ) {\r
+            if ( _label_direction_cbmi.isSelected() ) {\r
+                options.setNodeLabelDirection( NODE_LABEL_DIRECTION.RADIAL );\r
+            }\r
+            else {\r
+                options.setNodeLabelDirection( NODE_LABEL_DIRECTION.HORIZONTAL );\r
+            }\r
+        }\r
+        options.setShowOverview( ( _show_overview_cbmi != null ) && _show_overview_cbmi.isSelected() );\r
+        options.setShowConfidenceStddev( ( _show_confidence_stddev_cbmi != null )\r
+                && _show_confidence_stddev_cbmi.isSelected() );\r
+        if ( ( _show_branch_length_values_cbmi != null ) && _show_branch_length_values_cbmi.isEnabled() ) {\r
+            options.setShowBranchLengthValues( _show_branch_length_values_cbmi.isSelected() );\r
+        }\r
+        if ( ( _color_by_taxonomic_group_cbmi != null ) && _color_by_taxonomic_group_cbmi.isEnabled() ) {\r
+            options.setColorByTaxonomicGroup( _color_by_taxonomic_group_cbmi.isSelected() );\r
+        }\r
+        options.setPrintUsingActualSize( ( _print_using_actual_size_cbmi != null )\r
+                && ( _print_using_actual_size_cbmi.isSelected() ) );\r
+        options.setGraphicsExportUsingActualSize( ( _graphics_export_using_actual_size_cbmi != null )\r
+                && ( _graphics_export_using_actual_size_cbmi.isSelected() ) );\r
+        options.setAntialiasPrint( ( _antialias_print_cbmi != null ) && _antialias_print_cbmi.isSelected() );\r
+        if ( ( _use_brackets_for_conf_in_nh_export_cbmi != null )\r
+                && _use_brackets_for_conf_in_nh_export_cbmi.isSelected() ) {\r
+            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );\r
+        }\r
+        else if ( ( _use_internal_names_for_conf_in_nh_export_cbmi != null )\r
+                && _use_internal_names_for_conf_in_nh_export_cbmi.isSelected() ) {\r
+            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );\r
+        }\r
+        else {\r
+            options.setNhConversionSupportValueStyle( NH_CONVERSION_SUPPORT_VALUE_STYLE.NONE );\r
+        }\r
+        options.setPrintBlackAndWhite( ( _print_black_and_white_cbmi != null )\r
+                && _print_black_and_white_cbmi.isSelected() );\r
+        options.setInternalNumberAreConfidenceForNhParsing( ( _internal_number_are_confidence_for_nh_parsing_cbmi != null )\r
+                && _internal_number_are_confidence_for_nh_parsing_cbmi.isSelected() );\r
+        if ( ( _extract_taxonomy_pfam_strict_rbmi != null ) && _extract_taxonomy_pfam_strict_rbmi.isSelected() ) {\r
+            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );\r
+        }\r
+        else if ( ( _extract_taxonomy_pfam_relaxed_rbmi != null ) && _extract_taxonomy_pfam_relaxed_rbmi.isSelected() ) {\r
+            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );\r
+        }\r
+        else if ( ( _extract_taxonomy_agressive_rbmi != null ) && _extract_taxonomy_agressive_rbmi.isSelected() ) {\r
+            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.AGGRESSIVE );\r
+        }\r
+        else if ( ( _extract_taxonomy_no_rbmi != null ) && _extract_taxonomy_no_rbmi.isSelected() ) {\r
+            options.setTaxonomyExtraction( TAXONOMY_EXTRACTION.NO );\r
+        }\r
+        options.setReplaceUnderscoresInNhParsing( ( _replace_underscores_cbmi != null )\r
+                && _replace_underscores_cbmi.isSelected() );\r
+        options.setAllowErrorsInDistanceToParent( ( _allow_errors_in_distance_to_parent_cbmi != null )\r
+                && _allow_errors_in_distance_to_parent_cbmi.isSelected() );\r
+        options.setMatchWholeTermsOnly( ( _search_whole_words_only_cbmi != null )\r
+                && _search_whole_words_only_cbmi.isSelected() );\r
+        options.setInverseSearchResult( ( _inverse_search_result_cbmi != null )\r
+                && _inverse_search_result_cbmi.isSelected() );\r
+        if ( _graphics_export_visible_only_cbmi != null ) {\r
+            options.setGraphicsExportVisibleOnly( _graphics_export_visible_only_cbmi.isSelected() );\r
+            if ( _graphics_export_visible_only_cbmi.isSelected() && ( _graphics_export_using_actual_size_cbmi != null ) ) {\r
+                _graphics_export_using_actual_size_cbmi.setSelected( true );\r
+                _graphics_export_using_actual_size_cbmi.setEnabled( false );\r
+            }\r
+            else {\r
+                _graphics_export_using_actual_size_cbmi.setEnabled( true );\r
+            }\r
+        }\r
+        if ( ( _rectangular_type_cbmi != null ) && _rectangular_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+        }\r
+        else if ( ( _triangular_type_cbmi != null ) && _triangular_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.TRIANGULAR );\r
+        }\r
+        else if ( ( _curved_type_cbmi != null ) && _curved_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CURVED );\r
+        }\r
+        else if ( ( _convex_type_cbmi != null ) && _convex_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CONVEX );\r
+        }\r
+        else if ( ( _euro_type_cbmi != null ) && _euro_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE );\r
+        }\r
+        else if ( ( _rounded_type_cbmi != null ) && _rounded_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.ROUNDED );\r
+        }\r
+        else if ( ( _unrooted_type_cbmi != null ) && _unrooted_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.UNROOTED );\r
+        }\r
+        else if ( ( _circular_type_cbmi != null ) && _circular_type_cbmi.isSelected() ) {\r
+            options.setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.CIRCULAR );\r
+        }\r
+    }\r
+\r
+    void updateTypeCheckboxes( final Options options, final Object o ) {\r
+        setTypeMenuToAllUnselected();\r
+        ( ( JCheckBoxMenuItem ) o ).setSelected( true );\r
+    }\r
+\r
+    void viewAsNexus() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {\r
+            String title = "Nexus";\r
+            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {\r
+                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;\r
+            }\r
+            showTextFrame( _mainpanel.getCurrentPhylogeny().toNexus( getOptions().getNhConversionSupportValueStyle() ),\r
+                           title );\r
+        }\r
+    }\r
+\r
+    void viewAsNH() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {\r
+            String title = "New Hampshire";\r
+            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {\r
+                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;\r
+            }\r
+            showTextFrame( _mainpanel.getCurrentPhylogeny().toNewHampshire( getOptions()\r
+                                   .getNhConversionSupportValueStyle() ),\r
+                           title );\r
+        }\r
+    }\r
+\r
+    void viewAsXML() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() != null ) && !_mainpanel.getCurrentPhylogeny().isEmpty() ) {\r
+            String title = "phyloXML";\r
+            if ( !ForesterUtil.isEmpty( _mainpanel.getCurrentPhylogeny().getName() ) ) {\r
+                title = "\"" + getMainPanel().getCurrentPhylogeny().getName() + "\" in " + title;\r
+            }\r
+            showTextFrame( _mainpanel.getCurrentPhylogeny().toPhyloXML( 0 ), title );\r
+        }\r
+    }\r
+\r
+    private void annotateSequences() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Set<Long> nodes = getCurrentTreePanel().getFoundNodes0();\r
+            if ( ( nodes == null ) || nodes.isEmpty() ) {\r
+                JOptionPane\r
+                        .showMessageDialog( this,\r
+                                            "Need to select nodes, either via direct selection or via the \"Search\" function",\r
+                                            "No nodes selected for annotation",\r
+                                            JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            final Phylogeny phy = getMainPanel().getCurrentPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final JTextField ref_field = new JTextField( 10 );\r
+                final JTextField desc_filed = new JTextField( 20 );\r
+                ref_field.setText( ForesterUtil.isEmpty( getPreviousNodeAnnotationReference() ) ? ""\r
+                        : getPreviousNodeAnnotationReference() );\r
+                final JPanel my_panel = new JPanel();\r
+                my_panel.add( new JLabel( "Reference " ) );\r
+                my_panel.add( ref_field );\r
+                my_panel.add( Box.createHorizontalStrut( 15 ) );\r
+                my_panel.add( new JLabel( "Description " ) );\r
+                my_panel.add( desc_filed );\r
+                final int result = JOptionPane.showConfirmDialog( null,\r
+                                                                  my_panel,\r
+                                                                  "Enter the sequence annotation(s) for the "\r
+                                                                          + nodes.size() + " selected nodes",\r
+                                                                  JOptionPane.OK_CANCEL_OPTION );\r
+                if ( result == JOptionPane.OK_OPTION ) {\r
+                    String ref = ref_field.getText();\r
+                    String desc = desc_filed.getText();\r
+                    if ( !ForesterUtil.isEmpty( ref ) ) {\r
+                        ref = ref.trim();\r
+                        ref = ref.replaceAll( "\\s+", " " );\r
+                        if ( ( ref.indexOf( ':' ) < 1 ) || ( ref.indexOf( ':' ) > ( ref.length() - 2 ) )\r
+                                || ( ref.length() < 3 ) ) {\r
+                            JOptionPane.showMessageDialog( this,\r
+                                                           "Reference needs to be in the form of \"GO:1234567\"",\r
+                                                           "Illegal Format for Annotation Reference",\r
+                                                           JOptionPane.ERROR_MESSAGE );\r
+                            return;\r
+                        }\r
+                    }\r
+                    if ( ref != null ) {\r
+                        setPreviousNodeAnnotationReference( ref );\r
+                    }\r
+                    if ( desc != null ) {\r
+                        desc = desc.trim();\r
+                        desc = desc.replaceAll( "\\s+", " " );\r
+                    }\r
+                    if ( !ForesterUtil.isEmpty( ref ) || !ForesterUtil.isEmpty( desc ) ) {\r
+                        for( final Long id : nodes ) {\r
+                            final PhylogenyNode n = phy.getNode( id );\r
+                            ForesterUtil.ensurePresenceOfSequence( n );\r
+                            final Annotation ann = ForesterUtil.isEmpty( ref ) ? new Annotation()\r
+                                    : new Annotation( ref );\r
+                            if ( !ForesterUtil.isEmpty( desc ) ) {\r
+                                ann.setDesc( desc );\r
+                            }\r
+                            n.getNodeData().getSequence().addAnnotation( ann );\r
+                        }\r
+                    }\r
+                    getMainPanel().getControlPanel().showAnnotations();\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    private void chooseFont() {\r
+        final FontChooser fc = new FontChooser();\r
+        fc.setFont( getMainPanel().getTreeFontSet().getLargeFont() );\r
+        fc.showDialog( this, "Select the Base Font" );\r
+        getMainPanel().getTreeFontSet().setBaseFont( fc.getFont() );\r
+    }\r
+\r
+    private void chooseMinimalConfidence() {\r
+        final String s = ( String ) JOptionPane\r
+                .showInputDialog( this,\r
+                                  "Please enter the minimum for confidence values to be displayed.\n"\r
+                                          + "[current value: " + getOptions().getMinConfidenceValue() + "]\n",\r
+                                  "Minimal Confidence Value",\r
+                                  JOptionPane.QUESTION_MESSAGE,\r
+                                  null,\r
+                                  null,\r
+                                  getOptions().getMinConfidenceValue() );\r
+        if ( !ForesterUtil.isEmpty( s ) ) {\r
+            boolean success = true;\r
+            double m = 0.0;\r
+            final String m_str = s.trim();\r
+            if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                try {\r
+                    m = Double.parseDouble( m_str );\r
+                }\r
+                catch ( final Exception ex ) {\r
+                    success = false;\r
+                }\r
+            }\r
+            else {\r
+                success = false;\r
+            }\r
+            if ( success && ( m >= 0.0 ) ) {\r
+                getOptions().setMinConfidenceValue( m );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void doUpdateProcessMenu() {\r
+        if ( _process_pool.size() > 0 ) {\r
+            if ( _process_menu == null ) {\r
+                _process_menu = createMenu( "", getConfiguration() );\r
+                _process_menu.setForeground( Color.RED );\r
+            }\r
+            _process_menu.removeAll();\r
+            final String text = "processes running: " + _process_pool.size();\r
+            _process_menu.setText( text );\r
+            _jmenubar.add( _process_menu );\r
+            for( int i = 0; i < _process_pool.size(); ++i ) {\r
+                final ProcessRunning p = _process_pool.getProcessByIndex( i );\r
+                _process_menu.add( customizeJMenuItem( new JMenuItem( p.getName() + " [" + p.getStart() + "]" ) ) );\r
+            }\r
+        }\r
+        else {\r
+            if ( _process_menu != null ) {\r
+                _process_menu.removeAll();\r
+                _jmenubar.remove( _process_menu );\r
+            }\r
+        }\r
+        _jmenubar.validate();\r
+        _jmenubar.repaint();\r
+        repaint();\r
+    }\r
+\r
+    private String getPreviousNodeAnnotationReference() {\r
+        return _previous_node_annotation_ref;\r
+    }\r
+\r
+    private void removeBranchColors() {\r
+        if ( getMainPanel().getCurrentPhylogeny() != null ) {\r
+            AptxUtil.removeBranchColors( getMainPanel().getCurrentPhylogeny() );\r
+        }\r
+    }\r
+\r
+    private void removeVisualStyles() {\r
+        if ( getMainPanel().getCurrentPhylogeny() != null ) {\r
+            AptxUtil.removeVisualStyles( getMainPanel().getCurrentPhylogeny() );\r
+        }\r
+    }\r
+\r
+    private void setPreviousNodeAnnotationReference( final String previous_node_annotation_ref ) {\r
+        _previous_node_annotation_ref = previous_node_annotation_ref;\r
+    }\r
+\r
+    /**\r
+     * Display the about box.\r
+     */\r
+    static void about() {\r
+        final StringBuffer about = new StringBuffer( "Archaeopteryx\nVersion " + Constants.VERSION + "\n" );\r
+        about.append( "Copyright (C) 2013 Christian M. Zmasek\n" );\r
+        about.append( "All Rights Reserved\n" );\r
+        about.append( "License: GNU Lesser General Public License (LGPL)\n" );\r
+        about.append( "Last modified: " + Constants.PRG_DATE + "\n" );\r
+        about.append( "Based on: " + ForesterUtil.getForesterLibraryInformation() + "\n" );\r
+        about.append( "phyloXML version : " + ForesterConstants.PHYLO_XML_VERSION + "\n" );\r
+        about.append( "phyloXML location: " + ForesterConstants.PHYLO_XML_LOCATION + "\n" );\r
+        if ( !ForesterUtil.isEmpty( ForesterUtil.JAVA_VERSION ) && !ForesterUtil.isEmpty( ForesterUtil.JAVA_VENDOR ) ) {\r
+            about.append( "[your Java version: " + ForesterUtil.JAVA_VERSION + " " + ForesterUtil.JAVA_VENDOR + "]\n" );\r
+        }\r
+        if ( !ForesterUtil.isEmpty( ForesterUtil.OS_NAME ) && !ForesterUtil.isEmpty( ForesterUtil.OS_ARCH )\r
+                && !ForesterUtil.isEmpty( ForesterUtil.OS_VERSION ) ) {\r
+            about.append( "[your OS: " + ForesterUtil.OS_NAME + " " + ForesterUtil.OS_ARCH + " "\r
+                    + ForesterUtil.OS_VERSION + "]\n" );\r
+        }\r
+        final Runtime rt = java.lang.Runtime.getRuntime();\r
+        final long free_memory = rt.freeMemory() / 1000000;\r
+        final long total_memory = rt.totalMemory() / 1000000;\r
+        about.append( "[free memory: " + free_memory + "MB, total memory: " + total_memory + "MB]\n" );\r
+        about.append( "[locale: " + Locale.getDefault() + "]\n" );\r
+        about.append( "References:\n" );\r
+        about.append( Constants.PHYLOXML_REFERENCE_SHORT + "\n" );\r
+        about.append( "For more information & download:\n" );\r
+        about.append( Constants.APTX_WEB_SITE + "\n" );\r
+        about.append( "Comments: " + Constants.AUTHOR_EMAIL );\r
+        JOptionPane.showMessageDialog( null, about, Constants.PRG_NAME, JOptionPane.PLAIN_MESSAGE );\r
+    }\r
+\r
+    static void chooseNodeSize( final Options options, final Component parent ) {\r
+        final String s = ( String ) JOptionPane.showInputDialog( parent,\r
+                                                                 "Please enter the default size for node shapes.\n"\r
+                                                                         + "[current value: "\r
+                                                                         + options.getDefaultNodeShapeSize() + "]\n",\r
+                                                                 "Node Shape Size",\r
+                                                                 JOptionPane.QUESTION_MESSAGE,\r
+                                                                 null,\r
+                                                                 null,\r
+                                                                 options.getDefaultNodeShapeSize() );\r
+        if ( !ForesterUtil.isEmpty( s ) ) {\r
+            boolean success = true;\r
+            double m = 0.0;\r
+            final String m_str = s.trim();\r
+            if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                try {\r
+                    m = Double.parseDouble( m_str );\r
+                }\r
+                catch ( final Exception ex ) {\r
+                    success = false;\r
+                }\r
+            }\r
+            else {\r
+                success = false;\r
+            }\r
+            if ( success && ( m >= 0.0 ) ) {\r
+                final short size = ForesterUtil.roundToShort( m );\r
+                if ( size >= 0.0 ) {\r
+                    options.setDefaultNodeShapeSize( size );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    static String createCurrentFontDesc( final TreeFontSet tree_font_set ) {\r
+        return tree_font_set.getLargeFont().getFamily() + " " + tree_font_set.getLargeFont().getSize();\r
+    }\r
+\r
+    static JMenu createMenu( final String title, final Configuration conf ) {\r
+        final JMenu jmenu = new JMenu( title );\r
+        if ( !conf.isUseNativeUI() ) {\r
+            jmenu.setFont( MainFrame.menu_font );\r
+            jmenu.setBackground( conf.getGuiMenuBackgroundColor() );\r
+            jmenu.setForeground( conf.getGuiMenuTextColor() );\r
+        }\r
+        return jmenu;\r
+    }\r
+\r
+    static JMenuItem customizeMenuItemAsLabel( final JMenuItem label, final Configuration configuration ) {\r
+        label.setFont( MainFrame.menu_font.deriveFont( Font.BOLD ) );\r
+        if ( !configuration.isUseNativeUI() ) {\r
+            label.setBackground( configuration.getGuiMenuBackgroundColor() );\r
+            label.setForeground( configuration.getGuiMenuTextColor() );\r
+            label.setOpaque( true );\r
+        }\r
+        label.setSelected( false );\r
+        label.setEnabled( false );\r
+        return label;\r
+    }\r
+\r
+    static void cycleNodeFill( final Options op, final TreePanel tree_panel ) {\r
+        switch ( op.getDefaultNodeFill() ) {\r
+            case GRADIENT:\r
+                op.setDefaultNodeFill( NodeFill.SOLID );\r
+                break;\r
+            case NONE:\r
+                op.setDefaultNodeFill( NodeFill.GRADIENT );\r
+                break;\r
+            case SOLID:\r
+                op.setDefaultNodeFill( NodeFill.NONE );\r
+                break;\r
+            default:\r
+                throw new RuntimeException( "unknown fill: " + op.getDefaultNodeFill() );\r
+        }\r
+    }\r
+\r
+    static void cycleNodeShape( final Options op, final TreePanel tree_panel ) {\r
+        switch ( op.getDefaultNodeShape() ) {\r
+            case CIRCLE:\r
+                op.setDefaultNodeShape( NodeShape.RECTANGLE );\r
+                break;\r
+            case RECTANGLE:\r
+                op.setDefaultNodeShape( NodeShape.CIRCLE );\r
+                break;\r
+            default:\r
+                throw new RuntimeException( "unknown shape: " + op.getDefaultNodeShape() );\r
+        }\r
+    }\r
+\r
+    static void cycleOverview( final Options op, final TreePanel tree_panel ) {\r
+        switch ( op.getOvPlacement() ) {\r
+            case LOWER_LEFT:\r
+                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.UPPER_LEFT );\r
+                break;\r
+            case LOWER_RIGHT:\r
+                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.LOWER_LEFT );\r
+                break;\r
+            case UPPER_LEFT:\r
+                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.UPPER_RIGHT );\r
+                break;\r
+            case UPPER_RIGHT:\r
+                op.setOvPlacement( Options.OVERVIEW_PLACEMENT_TYPE.LOWER_RIGHT );\r
+                break;\r
+            default:\r
+                throw new RuntimeException( "unknown placement: " + op.getOvPlacement() );\r
+        }\r
+        if ( tree_panel != null ) {\r
+            tree_panel.updateOvSettings();\r
+        }\r
+    }\r
+\r
+    static void setCycleNodeFillMenuItem( final JMenuItem mi, final Options options ) {\r
+        if ( ( options != null ) && ( options.getDefaultNodeFill() != null ) ) {\r
+            mi.setText( "Cycle Node Shape Fill Type... (current: "\r
+                    + options.getDefaultNodeFill().toString().toLowerCase() + ")" );\r
+        }\r
+        else {\r
+            mi.setText( "Cycle Node Shape Fill Type..." );\r
+        }\r
+    }\r
+\r
+    static void setCycleNodeShapeMenuItem( final JMenuItem mi, final Options options ) {\r
+        if ( ( options != null ) && ( options.getDefaultNodeShape() != null ) ) {\r
+            mi.setText( "Cycle Node Shape Fill Type... (current: "\r
+                    + options.getDefaultNodeShape().toString().toLowerCase() + ")" );\r
+        }\r
+        else {\r
+            mi.setText( "Cycle Node Shape Fill Type..." );\r
+        }\r
+    }\r
+\r
+    static void setOvPlacementColorChooseMenuItem( final JMenuItem mi, final Options options ) {\r
+        if ( ( options != null ) && ( options.getOvPlacement() != null ) ) {\r
+            mi.setText( "Cycle Overview Placement... (current: " + options.getOvPlacement() + ")" );\r
+        }\r
+        else {\r
+            mi.setText( "Cycle Overview Placement..." );\r
+        }\r
+    }\r
+\r
+    static void setTextColorChooseMenuItem( final JMenuItem mi, final TreePanel tree_panel ) {\r
+        if ( ( tree_panel != null ) && ( tree_panel.getTreeColorSet() != null ) ) {\r
+            mi.setText( "Select Color Scheme... (current: " + tree_panel.getTreeColorSet().getCurrentColorSchemeName()\r
+                    + ")" );\r
+        }\r
+        else {\r
+            mi.setText( "Select Color Scheme..." );\r
+        }\r
+    }\r
+\r
+    static void setTextForFontChooserMenuItem( final JMenuItem mi, final String font_desc ) {\r
+        mi.setText( "Select Default Font... (current: " + font_desc + ")" );\r
+    }\r
+\r
+    static void setTextMinSupportMenuItem( final JMenuItem mi, final Options options, final TreePanel current_tree_panel ) {\r
+        if ( ( current_tree_panel == null ) || ( current_tree_panel.getPhylogeny() == null ) ) {\r
+            mi.setEnabled( true );\r
+        }\r
+        else if ( AptxUtil.isHasAtLeastOneBranchWithSupportValues( current_tree_panel.getPhylogeny() ) ) {\r
+            mi.setEnabled( true );\r
+        }\r
+        else {\r
+            mi.setEnabled( false );\r
+        }\r
+        mi.setText( "Enter Min Confidence Value... (current: " + options.getMinConfidenceValue() + ")" );\r
+    }\r
+\r
+    static void setTextNodeSizeMenuItem( final JMenuItem mi, final Options options ) {\r
+        mi.setText( "Enter Default Node Shape Size... (current: " + options.getDefaultNodeShapeSize() + ")" );\r
+    }\r
+\r
+    static void updateOptionsMenuDependingOnPhylogenyType( final MainPanel main_panel,\r
+                                                           final JCheckBoxMenuItem scale,\r
+                                                           final JCheckBoxMenuItem branch_lengths,\r
+                                                           final JRadioButtonMenuItem non_lined_up,\r
+                                                           final JRadioButtonMenuItem uniform_clado,\r
+                                                           final JRadioButtonMenuItem nonuniform_clado,\r
+                                                           final JCheckBoxMenuItem label_direction_cbmi ) {\r
+        final TreePanel tree_panel = main_panel.getCurrentTreePanel();\r
+        final ControlPanel control = main_panel.getControlPanel();\r
+        final Options options = main_panel.getOptions();\r
+        scale.setSelected( options.isShowScale() );\r
+        branch_lengths.setSelected( options.isShowBranchLengthValues() );\r
+        // non_lined_up.setSelected( options.isNonLinedUpCladogram() );\r
+        if ( ( tree_panel != null ) && ( !tree_panel.isPhyHasBranchLengths() ) ) {\r
+            scale.setSelected( false );\r
+            scale.setEnabled( false );\r
+            branch_lengths.setSelected( false );\r
+            branch_lengths.setEnabled( false );\r
+        }\r
+        else if ( ( tree_panel != null ) && !control.isDrawPhylogram() ) {\r
+            scale.setSelected( false );\r
+            scale.setEnabled( false );\r
+            branch_lengths.setEnabled( true );\r
+        }\r
+        else {\r
+            scale.setEnabled( true );\r
+            branch_lengths.setEnabled( true );\r
+        }\r
+        if ( ( tree_panel != null )\r
+                && ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.ROUNDED )\r
+                        && ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE ) && ( tree_panel\r
+                        .getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR ) ) ) {\r
+            branch_lengths.setSelected( false );\r
+            branch_lengths.setEnabled( false );\r
+        }\r
+        if ( tree_panel != null ) {\r
+            if ( ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR )\r
+                    || ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) ) {\r
+                non_lined_up.setEnabled( false );\r
+                uniform_clado.setEnabled( false );\r
+                nonuniform_clado.setEnabled( false );\r
+            }\r
+            else {\r
+                non_lined_up.setEnabled( true );\r
+                uniform_clado.setEnabled( true );\r
+                nonuniform_clado.setEnabled( true );\r
+            }\r
+        }\r
+        else {\r
+            if ( ( tree_panel != null )\r
+                    && ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.EURO_STYLE ) && ( tree_panel\r
+                            .getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR ) ) ) {\r
+                branch_lengths.setSelected( false );\r
+                branch_lengths.setEnabled( false );\r
+            }\r
+            if ( ( tree_panel != null )\r
+                    && ( ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) || ( tree_panel\r
+                            .getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.UNROOTED ) ) ) {\r
+                non_lined_up.setEnabled( false );\r
+            }\r
+            else {\r
+                // non_lined_up.setSelected( options.isNonLinedUpCladogram() );\r
+                non_lined_up.setEnabled( true );\r
+            }\r
+        }\r
+        label_direction_cbmi.setEnabled( true );\r
+        if ( tree_panel != null ) {\r
+            if ( ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.UNROOTED )\r
+                    && ( tree_panel.getPhylogenyGraphicsType() != PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) ) {\r
+                label_direction_cbmi.setEnabled( false );\r
+            }\r
+            if ( tree_panel.getPhylogenyGraphicsType() == PHYLOGENY_GRAPHICS_TYPE.CIRCULAR ) {\r
+                scale.setSelected( false );\r
+                scale.setEnabled( false );\r
+            }\r
+        }\r
+    }\r
+\r
+    static void updateScreenTextAntialias( final List<TreePanel> treepanels ) {\r
+        for( final TreePanel tree_panel : treepanels ) {\r
+            tree_panel.setTextAntialias();\r
+        }\r
+    }\r
+}\r
index 6e13820..f37cb7c 100644 (file)
-// $Id:
-// FORESTER -- software libraries and applications
-// for evolutionary biology research and applications.
-//
-// Copyright (C) 2008-2009 Christian M. Zmasek
-// Copyright (C) 2008-2009 Burnham Institute for Medical Research
-// Copyright (C) 2003-2007 Ethalinda K.S. Cannon
-// All rights reserved
-//
-// This library is free software; you can redistribute it and/or
-// modify it under the terms of the GNU Lesser General Public
-// License as published by the Free Software Foundation; either
-// version 2.1 of the License, or (at your option) any later version.
-//
-// This library is distributed in the hope that it will be useful,
-// but WITHOUT ANY WARRANTY; without even the implied warranty of
-// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
-// Lesser General Public License for more details.
-//
-// You should have received a copy of the GNU Lesser General Public
-// License along with this library; if not, write to the Free Software
-// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA
-//
-// Contact: phylosoft @ gmail . com
-// WWW: https://sites.google.com/site/cmzmasek/home/software/forester
-
-package org.forester.archaeopteryx;
-
-import java.awt.BorderLayout;
-import java.awt.Font;
-import java.awt.event.ActionEvent;
-import java.awt.event.ComponentAdapter;
-import java.awt.event.ComponentEvent;
-import java.awt.event.WindowAdapter;
-import java.awt.event.WindowEvent;
-import java.io.File;
-import java.io.FileInputStream;
-import java.io.IOException;
-import java.io.InputStream;
-import java.util.ArrayList;
-import java.util.HashSet;
-import java.util.List;
-import java.util.Set;
-
-import javax.swing.ButtonGroup;
-import javax.swing.JCheckBoxMenuItem;
-import javax.swing.JFileChooser;
-import javax.swing.JMenu;
-import javax.swing.JMenuBar;
-import javax.swing.JMenuItem;
-import javax.swing.JOptionPane;
-import javax.swing.JRadioButtonMenuItem;
-import javax.swing.UIManager;
-import javax.swing.UnsupportedLookAndFeelException;
-import javax.swing.WindowConstants;
-import javax.swing.event.ChangeEvent;
-import javax.swing.event.ChangeListener;
-import javax.swing.filechooser.FileFilter;
-import javax.swing.plaf.synth.SynthLookAndFeel;
-
-import org.forester.analysis.TaxonomyDataManager;
-import org.forester.archaeopteryx.AptxUtil.GraphicsExportType;
-import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;
-import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;
-import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;
-import org.forester.archaeopteryx.tools.AncestralTaxonomyInferrer;
-import org.forester.archaeopteryx.tools.InferenceManager;
-import org.forester.archaeopteryx.tools.PhyloInferenceDialog;
-import org.forester.archaeopteryx.tools.PhylogeneticInferenceOptions;
-import org.forester.archaeopteryx.tools.PhylogeneticInferrer;
-import org.forester.archaeopteryx.tools.SequenceDataRetriver;
-import org.forester.archaeopteryx.webservices.PhylogeniesWebserviceClient;
-import org.forester.archaeopteryx.webservices.WebservicesManager;
-import org.forester.io.parsers.FastaParser;
-import org.forester.io.parsers.GeneralMsaParser;
-import org.forester.io.parsers.PhylogenyParser;
-import org.forester.io.parsers.nexus.NexusPhylogeniesParser;
-import org.forester.io.parsers.nhx.NHXParser;
-import org.forester.io.parsers.nhx.NHXParser.TAXONOMY_EXTRACTION;
-import org.forester.io.parsers.phyloxml.PhyloXmlDataFormatException;
-import org.forester.io.parsers.phyloxml.PhyloXmlParser;
-import org.forester.io.parsers.phyloxml.PhyloXmlUtil;
-import org.forester.io.parsers.tol.TolParser;
-import org.forester.io.parsers.util.ParserUtils;
-import org.forester.io.writers.PhylogenyWriter;
-import org.forester.io.writers.SequenceWriter;
-import org.forester.msa.Msa;
-import org.forester.msa.MsaFormatException;
-import org.forester.phylogeny.Phylogeny;
-import org.forester.phylogeny.PhylogenyMethods;
-import org.forester.phylogeny.PhylogenyNode;
-import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;
-import org.forester.phylogeny.data.Confidence;
-import org.forester.phylogeny.data.Taxonomy;
-import org.forester.phylogeny.iterators.PhylogenyNodeIterator;
-import org.forester.sequence.Sequence;
-import org.forester.util.BasicDescriptiveStatistics;
-import org.forester.util.BasicTable;
-import org.forester.util.BasicTableParser;
-import org.forester.util.DescriptiveStatistics;
-import org.forester.util.ForesterUtil;
-import org.forester.util.WindowsUtils;
-
-public final class MainFrameApplication extends MainFrame {
-
-    static final String                      INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";
-    static final String                      OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";
-    private final static int                 FRAME_X_SIZE                          = 800;
-    private final static int                 FRAME_Y_SIZE                          = 800;
-    // Filters for the file-open dialog (classes defined in this file)
-    private final static NHFilter            nhfilter                              = new NHFilter();
-    private final static NHXFilter           nhxfilter                             = new NHXFilter();
-    private final static XMLFilter           xmlfilter                             = new XMLFilter();
-    private final static TolFilter           tolfilter                             = new TolFilter();
-    private final static NexusFilter         nexusfilter                           = new NexusFilter();
-    private final static PdfFilter           pdffilter                             = new PdfFilter();
-    private final static GraphicsFileFilter  graphicsfilefilter                    = new GraphicsFileFilter();
-    private final static MsaFileFilter       msafilter                             = new MsaFileFilter();
-    private final static SequencesFileFilter seqsfilter                            = new SequencesFileFilter();
-    private final static DefaultFilter       defaultfilter                         = new DefaultFilter();
-    private static final long                serialVersionUID                      = -799735726778865234L;
-    private final JFileChooser               _values_filechooser;
-    private final JFileChooser               _sequences_filechooser;
-    private final JFileChooser               _open_filechooser;
-    private final JFileChooser               _msa_filechooser;
-    private final JFileChooser               _seqs_pi_filechooser;
-    private final JFileChooser               _open_filechooser_for_species_tree;
-    private final JFileChooser               _save_filechooser;
-    private final JFileChooser               _writetopdf_filechooser;
-    private final JFileChooser               _writetographics_filechooser;
-    // Application-only print menu items
-    private JMenuItem                        _print_item;
-    private JMenuItem                        _write_to_pdf_item;
-    private JMenuItem                        _write_to_jpg_item;
-    private JMenuItem                        _write_to_gif_item;
-    private JMenuItem                        _write_to_tif_item;
-    private JMenuItem                        _write_to_png_item;
-    private JMenuItem                        _write_to_bmp_item;
-    private File                             _current_dir;
-    private ButtonGroup                      _radio_group_1;
-    private ButtonGroup                      _radio_group_2;
-    // Others:
-    double                                   _min_not_collapse                     = Constants.MIN_NOT_COLLAPSE_DEFAULT;
-    // Phylogeny Inference menu
-    private JMenu                            _inference_menu;
-    private JMenuItem                        _inference_from_msa_item;
-    private JMenuItem                        _inference_from_seqs_item;
-    // Phylogeny Inference
-    private PhylogeneticInferenceOptions     _phylogenetic_inference_options       = null;
-    private Msa                              _msa                                  = null;
-    private File                             _msa_file                             = null;
-    private List<Sequence>                   _seqs                                 = null;
-    private File                             _seqs_file                            = null;
-    JMenuItem                                _read_values_jmi;
-    JMenuItem                                _read_seqs_jmi;
-
-    private MainFrameApplication( final Phylogeny[] phys, final Configuration config ) {
-        _configuration = config;
-        if ( _configuration == null ) {
-            throw new IllegalArgumentException( "configuration is null" );
-        }
-        setVisible( false );
-        setOptions( Options.createInstance( _configuration ) );
-        _mainpanel = new MainPanel( _configuration, this );
-        _open_filechooser = null;
-        _open_filechooser_for_species_tree = null;
-        _save_filechooser = null;
-        _writetopdf_filechooser = null;
-        _writetographics_filechooser = null;
-        _msa_filechooser = null;
-        _seqs_pi_filechooser = null;
-        _values_filechooser = null;
-        _sequences_filechooser = null;
-        _jmenubar = new JMenuBar();
-        buildFileMenu();
-        buildTypeMenu();
-        _contentpane = getContentPane();
-        _contentpane.setLayout( new BorderLayout() );
-        _contentpane.add( _mainpanel, BorderLayout.CENTER );
-        // App is this big
-        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );
-        // The window listener
-        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );
-        addWindowListener( new WindowAdapter() {
-
-            @Override
-            public void windowClosing( final WindowEvent e ) {
-                exit();
-            }
-        } );
-        //   setVisible( true );
-        if ( ( phys != null ) && ( phys.length > 0 ) ) {
-            AptxUtil.addPhylogeniesToTabs( phys, "", null, _configuration, _mainpanel );
-            validate();
-            getMainPanel().getControlPanel().showWholeAll();
-            getMainPanel().getControlPanel().showWhole();
-        }
-        //activateSaveAllIfNeeded();
-        // ...and its children
-        _contentpane.repaint();
-    }
-
-    private MainFrameApplication( final Phylogeny[] phys, final Configuration config, final String title ) {
-        this( phys, config, title, null );
-    }
-
-    private MainFrameApplication( final Phylogeny[] phys,
-                                  final Configuration config,
-                                  final String title,
-                                  final File current_dir ) {
-        super();
-        _configuration = config;
-        if ( _configuration == null ) {
-            throw new IllegalArgumentException( "configuration is null" );
-        }
-        try {
-            boolean synth_exception = false;
-            if ( Constants.__SYNTH_LF ) {
-                try {
-                    final SynthLookAndFeel synth = new SynthLookAndFeel();
-                    synth.load( MainFrameApplication.class.getResourceAsStream( "/resources/synth_look_and_feel_1.xml" ),
-                                MainFrameApplication.class );
-                    UIManager.setLookAndFeel( synth );
-                }
-                catch ( final Exception ex ) {
-                    synth_exception = true;
-                    ForesterUtil.printWarningMessage( Constants.PRG_NAME,
-                                                      "could not create synth look and feel: "
-                                                              + ex.getLocalizedMessage() );
-                }
-            }
-            if ( !Constants.__SYNTH_LF || synth_exception ) {
-                if ( _configuration.isUseNativeUI() ) {
-                    UIManager.setLookAndFeel( UIManager.getSystemLookAndFeelClassName() );
-                }
-                else {
-                    UIManager.setLookAndFeel( UIManager.getCrossPlatformLookAndFeelClassName() );
-                }
-            }
-            //UIManager.setLookAndFeel( "com.sun.java.swing.plaf.nimbus.NimbusLookAndFeel" );
-        }
-        catch ( final UnsupportedLookAndFeelException e ) {
-            AptxUtil.dieWithSystemError( "unsupported look and feel: " + e.toString() );
-        }
-        catch ( final ClassNotFoundException e ) {
-            AptxUtil.dieWithSystemError( "class not found exception: " + e.toString() );
-        }
-        catch ( final InstantiationException e ) {
-            AptxUtil.dieWithSystemError( "instantiation exception: " + e.toString() );
-        }
-        catch ( final IllegalAccessException e ) {
-            AptxUtil.dieWithSystemError( "illegal access exception: " + e.toString() );
-        }
-        if ( ( current_dir != null ) && current_dir.canRead() && current_dir.isDirectory() ) {
-            setCurrentDir( current_dir );
-        }
-        // hide until everything is ready
-        setVisible( false );
-        setOptions( Options.createInstance( _configuration ) );
-        setInferenceManager( InferenceManager.createInstance( _configuration ) );
-        setPhylogeneticInferenceOptions( PhylogeneticInferenceOptions.createInstance( _configuration ) );
-        //     _textframe = null; #~~~~
-        // set title
-        setTitle( Constants.PRG_NAME + " " + Constants.VERSION + " (" + Constants.PRG_DATE + ")" );
-        _mainpanel = new MainPanel( _configuration, this );
-        // The file dialogs
-        _open_filechooser = new JFileChooser();
-        _open_filechooser.setCurrentDirectory( new File( "." ) );
-        _open_filechooser.setMultiSelectionEnabled( false );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.xmlfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhxfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );
-        _open_filechooser.addChoosableFileFilter( MainFrameApplication.tolfilter );
-        _open_filechooser.addChoosableFileFilter( _open_filechooser.getAcceptAllFileFilter() );
-        _open_filechooser.setFileFilter( MainFrameApplication.defaultfilter );
-        _open_filechooser_for_species_tree = new JFileChooser();
-        _open_filechooser_for_species_tree.setCurrentDirectory( new File( "." ) );
-        _open_filechooser_for_species_tree.setMultiSelectionEnabled( false );
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.xmlfilter );
-        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.tolfilter );
-        _open_filechooser_for_species_tree.setFileFilter( MainFrameApplication.xmlfilter );
-        _save_filechooser = new JFileChooser();
-        _save_filechooser.setCurrentDirectory( new File( "." ) );
-        _save_filechooser.setMultiSelectionEnabled( false );
-        _save_filechooser.setFileFilter( MainFrameApplication.xmlfilter );
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );
-        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );
-        _save_filechooser.addChoosableFileFilter( _save_filechooser.getAcceptAllFileFilter() );
-        _writetopdf_filechooser = new JFileChooser();
-        _writetopdf_filechooser.addChoosableFileFilter( MainFrameApplication.pdffilter );
-        _writetographics_filechooser = new JFileChooser();
-        _writetographics_filechooser.addChoosableFileFilter( MainFrameApplication.graphicsfilefilter );
-        // Msa:
-        _msa_filechooser = new JFileChooser();
-        _msa_filechooser.setName( "Read Multiple Sequence Alignment File" );
-        _msa_filechooser.setCurrentDirectory( new File( "." ) );
-        _msa_filechooser.setMultiSelectionEnabled( false );
-        _msa_filechooser.addChoosableFileFilter( _msa_filechooser.getAcceptAllFileFilter() );
-        _msa_filechooser.addChoosableFileFilter( MainFrameApplication.msafilter );
-        // Seqs:
-        _seqs_pi_filechooser = new JFileChooser();
-        _seqs_pi_filechooser.setName( "Read Sequences File" );
-        _seqs_pi_filechooser.setCurrentDirectory( new File( "." ) );
-        _seqs_pi_filechooser.setMultiSelectionEnabled( false );
-        _seqs_pi_filechooser.addChoosableFileFilter( _seqs_pi_filechooser.getAcceptAllFileFilter() );
-        _seqs_pi_filechooser.addChoosableFileFilter( MainFrameApplication.seqsfilter );
-        // Expression
-        _values_filechooser = new JFileChooser();
-        _values_filechooser.setCurrentDirectory( new File( "." ) );
-        _values_filechooser.setMultiSelectionEnabled( false );
-        // Sequences
-        _sequences_filechooser = new JFileChooser();
-        _sequences_filechooser.setCurrentDirectory( new File( "." ) );
-        _sequences_filechooser.setMultiSelectionEnabled( false );
-        // build the menu bar
-        _jmenubar = new JMenuBar();
-        if ( !_configuration.isUseNativeUI() ) {
-            _jmenubar.setBackground( getConfiguration().getGuiMenuBackgroundColor() );
-        }
-        buildFileMenu();
-        if ( Constants.__ALLOW_PHYLOGENETIC_INFERENCE ) {
-            buildPhylogeneticInferenceMenu();
-        }
-        buildAnalysisMenu();
-        buildToolsMenu();
-        buildViewMenu();
-        buildFontSizeMenu();
-        buildOptionsMenu();
-        buildTypeMenu();
-        buildHelpMenu();
-        setJMenuBar( _jmenubar );
-        _jmenubar.add( _help_jmenu );
-        _contentpane = getContentPane();
-        _contentpane.setLayout( new BorderLayout() );
-        _contentpane.add( _mainpanel, BorderLayout.CENTER );
-        // App is this big
-        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );
-        //        addWindowFocusListener( new WindowAdapter() {
-        //
-        //            @Override
-        //            public void windowGainedFocus( WindowEvent e ) {
-        //                requestFocusInWindow();
-        //            }
-        //        } );
-        // The window listener
-        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );
-        addWindowListener( new WindowAdapter() {
-
-            @Override
-            public void windowClosing( final WindowEvent e ) {
-                if ( isUnsavedDataPresent() ) {
-                    final int r = JOptionPane.showConfirmDialog( null,
-                                                                 "Exit despite potentially unsaved changes?",
-                                                                 "Exit?",
-                                                                 JOptionPane.YES_NO_OPTION );
-                    if ( r != JOptionPane.YES_OPTION ) {
-                        return;
-                    }
-                }
-                else {
-                    final int r = JOptionPane.showConfirmDialog( null,
-                                                                 "Exit Archaeopteryx?",
-                                                                 "Exit?",
-                                                                 JOptionPane.YES_NO_OPTION );
-                    if ( r != JOptionPane.YES_OPTION ) {
-                        return;
-                    }
-                }
-                exit();
-            }
-        } );
-        // The component listener
-        addComponentListener( new ComponentAdapter() {
-
-            @Override
-            public void componentResized( final ComponentEvent e ) {
-                if ( _mainpanel.getCurrentTreePanel() != null ) {
-                    _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel()
-                                                                                        .getWidth(),
-                                                                                _mainpanel.getCurrentTreePanel()
-                                                                                        .getHeight(),
-                                                                                getOptions().isAllowFontSizeChange() );
-                }
-            }
-        } );
-        requestFocusInWindow();
-        // addKeyListener( this );
-        setVisible( true );
-        if ( ( phys != null ) && ( phys.length > 0 ) ) {
-            AptxUtil.addPhylogeniesToTabs( phys, title, null, _configuration, _mainpanel );
-            validate();
-            getMainPanel().getControlPanel().showWholeAll();
-            getMainPanel().getControlPanel().showWhole();
-        }
-        activateSaveAllIfNeeded();
-        // ...and its children
-        _contentpane.repaint();
-        System.gc();
-    }
-
-    private MainFrameApplication( final Phylogeny[] phys, final String config_file, final String title ) {
-        // Reads the config file (false, false => not url, not applet):
-        this( phys, new Configuration( config_file, false, false, true ), title );
-    }
-
-    @Override
-    public void actionPerformed( final ActionEvent e ) {
-        try {
-            super.actionPerformed( e );
-            final Object o = e.getSource();
-            // Handle app-specific actions here:
-            if ( o == _open_item ) {
-                readPhylogeniesFromFile();
-            }
-            else if ( o == _save_item ) {
-                writeToFile( _mainpanel.getCurrentPhylogeny() );
-                // If subtree currently displayed, save it, instead of complete
-                // tree.
-            }
-            else if ( o == _new_item ) {
-                newTree();
-            }
-            else if ( o == _save_all_item ) {
-                writeAllToFile();
-            }
-            else if ( o == _close_item ) {
-                closeCurrentPane();
-            }
-            else if ( o == _write_to_pdf_item ) {
-                writeToPdf( _mainpanel.getCurrentPhylogeny() );
-            }
-            else if ( o == _write_to_jpg_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.JPG );
-            }
-            else if ( o == _write_to_png_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.PNG );
-            }
-            else if ( o == _write_to_gif_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.GIF );
-            }
-            else if ( o == _write_to_tif_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.TIFF );
-            }
-            else if ( o == _write_to_bmp_item ) {
-                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.BMP );
-            }
-            else if ( o == _print_item ) {
-                print();
-            }
-            else if ( o == _load_species_tree_item ) {
-                readSpeciesTreeFromFile();
-            }
-            else if ( o == _lineage_inference ) {
-                if ( isSubtreeDisplayed() ) {
-                    JOptionPane.showMessageDialog( this,
-                                                   "Subtree is shown.",
-                                                   "Cannot infer ancestral taxonomies",
-                                                   JOptionPane.ERROR_MESSAGE );
-                    return;
-                }
-                executeLineageInference();
-            }
-            else if ( o == _obtain_detailed_taxonomic_information_jmi ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                obtainDetailedTaxonomicInformation();
-            }
-            else if ( o == _obtain_detailed_taxonomic_information_deleting_jmi ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                obtainDetailedTaxonomicInformationDelete();
-            }
-            else if ( o == _obtain_seq_information_jmi ) {
-                obtainSequenceInformation();
-            }
-            else if ( o == _read_values_jmi ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                addExpressionValuesFromFile();
-            }
-            else if ( o == _read_seqs_jmi ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                addSequencesFromFile();
-            }
-            else if ( o == _move_node_names_to_tax_sn_jmi ) {
-                moveNodeNamesToTaxSn();
-            }
-            else if ( o == _move_node_names_to_seq_names_jmi ) {
-                moveNodeNamesToSeqNames();
-            }
-            else if ( o == _extract_tax_code_from_node_names_jmi ) {
-                extractTaxDataFromNodeNames();
-            }
-            else if ( o == _graphics_export_visible_only_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _antialias_print_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_black_and_white_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_using_actual_size_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _graphics_export_using_actual_size_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _print_size_mi ) {
-                choosePrintSize();
-            }
-            else if ( o == _choose_pdf_width_mi ) {
-                choosePdfWidth();
-            }
-            else if ( o == _internal_number_are_confidence_for_nh_parsing_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _replace_underscores_cbmi ) {
-                if ( ( _extract_taxonomy_no_rbmi != null ) && !_extract_taxonomy_no_rbmi.isSelected() ) {
-                    _extract_taxonomy_no_rbmi.setSelected( true );
-                }
-                updateOptions( getOptions() );
-            }
-            else if ( o == _allow_errors_in_distance_to_parent_cbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _collapse_below_threshold ) {
-                if ( isSubtreeDisplayed() ) {
-                    return;
-                }
-                collapseBelowThreshold();
-            }
-            else if ( ( o == _extract_taxonomy_pfam_strict_rbmi ) || ( o == _extract_taxonomy_pfam_relaxed_rbmi )
-                    || ( o == _extract_taxonomy_agressive_rbmi ) ) {
-                if ( _replace_underscores_cbmi != null ) {
-                    _replace_underscores_cbmi.setSelected( false );
-                }
-                updateOptions( getOptions() );
-            }
-            else if ( o == _extract_taxonomy_no_rbmi ) {
-                updateOptions( getOptions() );
-            }
-            else if ( o == _inference_from_msa_item ) {
-                executePhyleneticInference( false );
-            }
-            else if ( o == _inference_from_seqs_item ) {
-                executePhyleneticInference( true );
-            }
-            _contentpane.repaint();
-        }
-        catch ( final Exception ex ) {
-            AptxUtil.unexpectedException( ex );
-        }
-        catch ( final Error err ) {
-            AptxUtil.unexpectedError( err );
-        }
-    }
-
-    public void end() {
-        _mainpanel.terminate();
-        _contentpane.removeAll();
-        setVisible( false );
-        dispose();
-    }
-
-    @Override
-    public MainPanel getMainPanel() {
-        return _mainpanel;
-    }
-
-    public Msa getMsa() {
-        return _msa;
-    }
-
-    public File getMsaFile() {
-        return _msa_file;
-    }
-
-    public List<Sequence> getSeqs() {
-        return _seqs;
-    }
-
-    public File getSeqsFile() {
-        return _seqs_file;
-    }
-
-    public void readMsaFromFile() {
-        // Set an initial directory if none set yet
-        final File my_dir = getCurrentDir();
-        _msa_filechooser.setMultiSelectionEnabled( false );
-        // Open file-open dialog and set current directory
-        if ( my_dir != null ) {
-            _msa_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _msa_filechooser.showOpenDialog( _contentpane );
-        // All done: get the msa
-        final File file = _msa_filechooser.getSelectedFile();
-        setCurrentDir( _msa_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            setMsaFile( null );
-            setMsa( null );
-            Msa msa = null;
-            try {
-                final InputStream is = new FileInputStream( file );
-                if ( FastaParser.isLikelyFasta( file ) ) {
-                    msa = FastaParser.parseMsa( is );
-                }
-                else {
-                    msa = GeneralMsaParser.parse( is );
-                }
-            }
-            catch ( final MsaFormatException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Multiple sequence alignment format error",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IOException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Failed to read multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IllegalArgumentException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final Exception e ) {
-                setArrowCursor();
-                e.printStackTrace();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment is empty",
-                                               "Illegal Multiple Sequence Alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( msa.getNumberOfSequences() < 4 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment needs to contain at least 3 sequences",
-                                               "Illegal multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( msa.getLength() < 2 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence alignment needs to contain at least 2 residues",
-                                               "Illegal multiple sequence alignment",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            System.gc();
-            setMsaFile( _msa_filechooser.getSelectedFile() );
-            setMsa( msa );
-        }
-    }
-
-    public void readSeqsFromFileforPI() {
-        // Set an initial directory if none set yet
-        final File my_dir = getCurrentDir();
-        _seqs_pi_filechooser.setMultiSelectionEnabled( false );
-        // Open file-open dialog and set current directory
-        if ( my_dir != null ) {
-            _seqs_pi_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );
-        // All done: get the seqs
-        final File file = _seqs_pi_filechooser.getSelectedFile();
-        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            setSeqsFile( null );
-            setSeqs( null );
-            List<Sequence> seqs = null;
-            try {
-                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {
-                    seqs = FastaParser.parse( new FileInputStream( file ) );
-                    for( final Sequence seq : seqs ) {
-                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );
-                    }
-                }
-                else {
-                    //TODO error
-                }
-            }
-            catch ( final MsaFormatException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Multiple sequence file format error",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IOException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Failed to read multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IllegalArgumentException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final Exception e ) {
-                setArrowCursor();
-                e.printStackTrace();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence file is empty",
-                                               "Illegal multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( seqs.size() < 4 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence file needs to contain at least 3 sequences",
-                                               "Illegal multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            //  if ( msa.getLength() < 2 ) {
-            //       JOptionPane.showMessageDialog( this,
-            //                                      "Multiple sequence alignment needs to contain at least 2 residues",
-            //                                      "Illegal multiple sequence file",
-            //                                      JOptionPane.ERROR_MESSAGE );
-            //       return;
-            //   }
-            System.gc();
-            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );
-            setSeqs( seqs );
-        }
-    }
-
-    void buildAnalysisMenu() {
-        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );
-        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );
-        _analysis_menu.add( _gsdir_item = new JMenuItem( "GSDIR (GSDI with re-rooting)" ) );
-        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );
-        customizeJMenuItem( _gsdi_item );
-        customizeJMenuItem( _gsdir_item );
-        customizeJMenuItem( _load_species_tree_item );
-        _analysis_menu.addSeparator();
-        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );
-        customizeJMenuItem( _lineage_inference );
-        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );
-        _jmenubar.add( _analysis_menu );
-    }
-
-    @Override
-    void buildFileMenu() {
-        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );
-        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );
-        _file_jmenu.addSeparator();
-        final WebservicesManager webservices_manager = WebservicesManager.getInstance();
-        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager
-                .getAvailablePhylogeniesWebserviceClients().size() ];
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
-            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );
-            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );
-            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );
-        }
-        if ( getConfiguration().isEditable() ) {
-            _file_jmenu.addSeparator();
-            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );
-            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );
-        }
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );
-        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );
-        _save_all_item.setToolTipText( "Write all phylogenies to one file." );
-        _save_all_item.setEnabled( false );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );
-        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" ) || AptxUtil.canWriteFormat( "TIF" ) ) {
-            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );
-        }
-        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );
-        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );
-        if ( AptxUtil.canWriteFormat( "gif" ) ) {
-            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );
-        }
-        if ( AptxUtil.canWriteFormat( "bmp" ) ) {
-            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );
-        }
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );
-        _close_item.setToolTipText( "To close the current pane." );
-        _close_item.setEnabled( true );
-        _file_jmenu.addSeparator();
-        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );
-        // For print in color option item
-        customizeJMenuItem( _open_item );
-        _open_item
-                .setFont( new Font( _open_item.getFont().getFontName(), Font.BOLD, _open_item.getFont().getSize() + 4 ) );
-        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {
-            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );
-        }
-        customizeJMenuItem( _save_item );
-        if ( getConfiguration().isEditable() ) {
-            customizeJMenuItem( _new_item );
-        }
-        customizeJMenuItem( _close_item );
-        customizeJMenuItem( _save_all_item );
-        customizeJMenuItem( _write_to_pdf_item );
-        customizeJMenuItem( _write_to_png_item );
-        customizeJMenuItem( _write_to_jpg_item );
-        customizeJMenuItem( _write_to_gif_item );
-        customizeJMenuItem( _write_to_tif_item );
-        customizeJMenuItem( _write_to_bmp_item );
-        customizeJMenuItem( _print_item );
-        customizeJMenuItem( _exit_item );
-        _jmenubar.add( _file_jmenu );
-    }
-
-    void buildOptionsMenu() {
-        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );
-        _options_jmenu.addChangeListener( new ChangeListener() {
-
-            @Override
-            public void stateChanged( final ChangeEvent e ) {
-                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );
-                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );
-                MainFrame
-                        .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );
-                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame
-                        .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );
-                setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );
-                setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );
-                MainFrame.updateOptionsMenuDependingOnPhylogenyType( getMainPanel(),
-                                                                     _show_scale_cbmi,
-                                                                     _show_branch_length_values_cbmi,
-                                                                     _non_lined_up_cladograms_rbmi,
-                                                                     _uniform_cladograms_rbmi,
-                                                                     _ext_node_dependent_cladogram_rbmi,
-                                                                     _label_direction_cbmi );
-                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );
-                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );
-                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );
-            }
-        } );
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );
-        _options_jmenu
-                .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );
-        _options_jmenu.add( _uniform_cladograms_rbmi = new JRadioButtonMenuItem( MainFrame.UNIFORM_CLADOGRAMS_LABEL ) );
-        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );
-        _radio_group_1 = new ButtonGroup();
-        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );
-        _radio_group_1.add( _uniform_cladograms_rbmi );
-        _radio_group_1.add( _non_lined_up_cladograms_rbmi );
-        ///////
-        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );
-        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );
-        _options_jmenu
-                .add( _show_branch_length_values_cbmi = new JCheckBoxMenuItem( DISPLAY_BRANCH_LENGTH_VALUES_LABEL ) );
-        _options_jmenu
-                .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );
-        _options_jmenu
-                .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );
-        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {
-            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( SHOW_DOMAIN_LABELS_LABEL ) );
-        }
-        _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );
-        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );
-        _options_jmenu.add( _color_by_taxonomic_group_cbmi = new JCheckBoxMenuItem( COLOR_BY_TAXONOMIC_GROUP ) );
-        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );
-        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );
-        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );
-        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );
-        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );
-        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );
-        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );
-        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );
-        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );
-        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );
-        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );
-        ///////
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );
-        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );
-        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );
-        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),
-                                                      getConfiguration() ) );
-        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );
-        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );
-        _options_jmenu
-                .add( _print_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PDF export and Printing" ) );
-        _options_jmenu
-                .add( _graphics_export_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PNG, JPG, and GIF export" ) );
-        _options_jmenu
-                .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );
-        _options_jmenu.add( _print_size_mi = new JMenuItem( "" ) );
-        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );
-        _options_jmenu.addSeparator();
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Input:" ), getConfiguration() ) );
-        _options_jmenu
-                .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );
-        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );
-        _options_jmenu
-                .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );
-        //
-        _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );
-        _options_jmenu
-                .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );
-        _options_jmenu
-                .add( _extract_taxonomy_pfam_relaxed_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style like Node Names" ) );
-        _options_jmenu
-                .add( _extract_taxonomy_agressive_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids/Scientific Names from Node Names" ) );
-        _extract_taxonomy_pfam_strict_rbmi
-                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"BCL2_MOUSE/123-304\" or \"BCL2_10090/123-304\"" );
-        _extract_taxonomy_pfam_relaxed_rbmi
-                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"bax_MOUSE\" or \"bax_10090\"" );
-        _extract_taxonomy_agressive_rbmi
-                .setToolTipText( "To extract taxonomy codes/ids or scientific names from node names in the form of e.g. \"MOUSE\" or \"10090\" or \"xyz_Nematostella_vectensis\"" );
-        _radio_group_2 = new ButtonGroup();
-        _radio_group_2.add( _extract_taxonomy_no_rbmi );
-        _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );
-        _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );
-        _radio_group_2.add( _extract_taxonomy_agressive_rbmi );
-        // 
-        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );
-        _options_jmenu
-                .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );
-        _use_brackets_for_conf_in_nh_export_cbmi
-                .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );
-        _options_jmenu
-                .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );
-        customizeJMenuItem( _choose_font_mi );
-        customizeJMenuItem( _choose_minimal_confidence_mi );
-        customizeJMenuItem( _switch_colors_mi );
-        customizeJMenuItem( _print_size_mi );
-        customizeJMenuItem( _choose_pdf_width_mi );
-        customizeJMenuItem( _overview_placment_mi );
-        customizeCheckBoxMenuItem( _show_default_node_shapes_external_cbmi, getOptions()
-                .isShowDefaultNodeShapesExternal() );
-        customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi, getOptions()
-                .isShowDefaultNodeShapesInternal() );
-        customizeJMenuItem( _cycle_node_shape_mi );
-        customizeJMenuItem( _cycle_node_fill_mi );
-        customizeJMenuItem( _choose_node_size_mi );
-        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );
-        customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );
-        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );
-        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );
-        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );
-        customizeCheckBoxMenuItem( _show_annotation_ref_source, getOptions().isShowAnnotationRefSource() );
-        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );
-        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );
-        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );
-        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );
-        customizeRadioButtonMenuItem( _uniform_cladograms_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );
-        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,
-                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );
-        customizeCheckBoxMenuItem( _show_branch_length_values_cbmi, getOptions().isShowBranchLengthValues() );
-        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );
-        customizeCheckBoxMenuItem( _label_direction_cbmi,
-                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );
-        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );
-        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );
-        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi, getOptions()
-                .isInternalNumberAreConfidenceForNhParsing() );
-        customizeRadioButtonMenuItem( _extract_taxonomy_no_rbmi,
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.NO );
-        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_strict_rbmi,
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );
-        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_relaxed_rbmi,
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );
-        customizeRadioButtonMenuItem( _extract_taxonomy_agressive_rbmi,
-                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.AGGRESSIVE );
-        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );
-        customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi, getOptions()
-                .isReplaceUnderscoresInNhParsing() );
-        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );
-        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );
-        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );
-        customizeCheckBoxMenuItem( _print_using_actual_size_cbmi, getOptions().isPrintUsingActualSize() );
-        customizeCheckBoxMenuItem( _graphics_export_using_actual_size_cbmi, getOptions()
-                .isGraphicsExportUsingActualSize() );
-        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );
-        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi, getOptions()
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );
-        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()
-                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );
-        _jmenubar.add( _options_jmenu );
-    }
-
-    void buildPhylogeneticInferenceMenu() {
-        final InferenceManager im = getInferenceManager();
-        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );
-        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );
-        customizeJMenuItem( _inference_from_msa_item );
-        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );
-        if ( im.canDoMsa() ) {
-            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );
-            customizeJMenuItem( _inference_from_seqs_item );
-            _inference_from_seqs_item
-                    .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );
-        }
-        else {
-            _inference_menu
-                    .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );
-            customizeJMenuItem( _inference_from_seqs_item );
-            _inference_from_seqs_item.setEnabled( false );
-        }
-        _jmenubar.add( _inference_menu );
-    }
-
-    void buildToolsMenu() {
-        _tools_menu = createMenu( "Tools", getConfiguration() );
-        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );
-        customizeJMenuItem( _confcolor_item );
-        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );
-        customizeJMenuItem( _color_rank_jmi );
-        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );
-        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );
-        customizeJMenuItem( _taxcolor_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _remove_visual_styles_item = new JMenuItem( "Delete All Visual Styles From Nodes" ) );
-        _remove_visual_styles_item
-                .setToolTipText( "To remove all node visual styles (fonts, colors) from the current phylogeny." );
-        customizeJMenuItem( _remove_visual_styles_item );
-        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete All Colors From Branches" ) );
-        _remove_branch_color_item.setToolTipText( "To remove all branch color values from the current phylogeny." );
-        customizeJMenuItem( _remove_branch_color_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );
-        customizeJMenuItem( _annotate_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );
-        customizeJMenuItem( _midpoint_root_item );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );
-        customizeJMenuItem( _collapse_species_specific_subtrees );
-        _tools_menu
-                .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );
-        customizeJMenuItem( _collapse_below_threshold );
-        _collapse_below_threshold
-                .setToolTipText( "To collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );
-        _tools_menu.addSeparator();
-        _tools_menu
-                .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );
-        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );
-        _extract_tax_code_from_node_names_jmi
-                .setToolTipText( "To extract SwissProt/Uniprot taxonomic codes (mnemonics) from nodes names in the form of 'xyz_CAEEL', Uniprot/NCBI identifiers form of 'xyz_6239', or scientific names form of 'xyz_Caenorhabditis_elegans'" );
-        _tools_menu
-                .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );
-        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );
-        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );
-        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );
-        customizeJMenuItem( _move_node_names_to_seq_names_jmi );
-        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );
-        customizeJMenuItem( _obtain_seq_information_jmi );
-        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );
-        _tools_menu
-                .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );
-        _obtain_detailed_taxonomic_information_jmi
-                .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );
-        _tools_menu
-                .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );
-        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );
-        _obtain_detailed_taxonomic_information_deleting_jmi
-                .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );
-        _tools_menu.addSeparator();
-        _tools_menu.add( _read_values_jmi = new JMenuItem( "Attach Vector/Expression Values" ) );
-        customizeJMenuItem( _read_values_jmi );
-        _read_values_jmi.setToolTipText( "To attach vector (e.g. gene expression) values to tree nodes (beta)" );
-        _jmenubar.add( _tools_menu );
-        _tools_menu.add( _read_seqs_jmi = new JMenuItem( "Attach Molecular Sequences" ) );
-        customizeJMenuItem( _read_seqs_jmi );
-        _read_seqs_jmi
-                .setToolTipText( "To attach molecular sequences to tree nodes (from Fasta-formatted file) (beta)" );
-        _jmenubar.add( _tools_menu );
-    }
-
-    @Override
-    void close() {
-        if ( isUnsavedDataPresent() ) {
-            final int r = JOptionPane.showConfirmDialog( this,
-                                                         "Exit despite potentially unsaved changes?",
-                                                         "Exit?",
-                                                         JOptionPane.YES_NO_OPTION );
-            if ( r != JOptionPane.YES_OPTION ) {
-                return;
-            }
-        }
-        exit();
-    }
-
-    void executeLineageInference() {
-        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {
-            return;
-        }
-        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Phylogeny is not rooted.",
-                                           "Cannot infer ancestral taxonomies",
-                                           JOptionPane.ERROR_MESSAGE );
-            return;
-        }
-        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,
-                                                                                  _mainpanel.getCurrentTreePanel(),
-                                                                                  _mainpanel.getCurrentPhylogeny()
-                                                                                          .copy() );
-        new Thread( inferrer ).start();
-    }
-
-    void exit() {
-        removeAllTextFrames();
-        _mainpanel.terminate();
-        _contentpane.removeAll();
-        setVisible( false );
-        dispose();
-        System.exit( 0 );
-    }
-
-    void setMsa( final Msa msa ) {
-        _msa = msa;
-    }
-
-    void setMsaFile( final File msa_file ) {
-        _msa_file = msa_file;
-    }
-
-    void setSeqs( final List<Sequence> seqs ) {
-        _seqs = seqs;
-    }
-
-    void setSeqsFile( final File seqs_file ) {
-        _seqs_file = seqs_file;
-    }
-
-    void writePhylogenyToGraphicsFile( final String file_name, final GraphicsExportType type ) {
-        _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel().getWidth(),
-                                                                    _mainpanel.getCurrentTreePanel().getHeight(),
-                                                                    true );
-        String file_written_to = "";
-        boolean error = false;
-        try {
-            file_written_to = AptxUtil.writePhylogenyToGraphicsFile( file_name,
-                                                                     _mainpanel.getCurrentTreePanel().getWidth(),
-                                                                     _mainpanel.getCurrentTreePanel().getHeight(),
-                                                                     _mainpanel.getCurrentTreePanel(),
-                                                                     _mainpanel.getControlPanel(),
-                                                                     type,
-                                                                     getOptions() );
-        }
-        catch ( final IOException e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error ) {
-            if ( ( file_written_to != null ) && ( file_written_to.length() > 0 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Wrote image to: " + file_written_to,
-                                               "Graphics Export",
-                                               JOptionPane.INFORMATION_MESSAGE );
-            }
-            else {
-                JOptionPane.showMessageDialog( this,
-                                               "There was an unknown problem when attempting to write to an image file: \""
-                                                       + file_name + "\"",
-                                               "Error",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-        }
-        _contentpane.repaint();
-    }
-
-    private void addExpressionValuesFromFile() {
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Need to load evolutionary tree first",
-                                           "Can Not Read Expression Values",
-                                           JOptionPane.WARNING_MESSAGE );
-            return;
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _values_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _values_filechooser.showOpenDialog( _contentpane );
-        final File file = _values_filechooser.getSelectedFile();
-        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            BasicTable<String> t = null;
-            try {
-                t = BasicTableParser.parse( file, '\t' );
-                if ( t.getNumberOfColumns() < 2 ) {
-                    t = BasicTableParser.parse( file, ',' );
-                }
-                if ( t.getNumberOfColumns() < 2 ) {
-                    t = BasicTableParser.parse( file, ' ' );
-                }
-            }
-            catch ( final IOException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               e.getMessage(),
-                                               "Could Not Read Expression Value Table",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( t.getNumberOfColumns() < 2 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Table contains " + t.getNumberOfColumns() + " column(s)",
-                                               "Problem with Expression Value Table",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( t.getNumberOfRows() < 1 ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Table contains zero rows",
-                                               "Problem with Expression Value Table",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( t.getNumberOfRows() != phy.getNumberOfExternalNodes() ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Table contains " + t.getNumberOfRows() + " rows, but tree contains "
-                                                       + phy.getNumberOfExternalNodes() + " external nodes",
-                                               "Warning",
-                                               JOptionPane.WARNING_MESSAGE );
-            }
-            final DescriptiveStatistics stats = new BasicDescriptiveStatistics();
-            int not_found = 0;
-            for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-                final PhylogenyNode node = iter.next();
-                final String node_name = node.getName();
-                if ( !ForesterUtil.isEmpty( node_name ) ) {
-                    int row = -1;
-                    try {
-                        row = t.findRow( node_name );
-                    }
-                    catch ( final IllegalArgumentException e ) {
-                        JOptionPane
-                                .showMessageDialog( this,
-                                                    e.getMessage(),
-                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",
-                                                    JOptionPane.ERROR_MESSAGE );
-                        return;
-                    }
-                    if ( row < 0 ) {
-                        if ( node.isExternal() ) {
-                            not_found++;
-                        }
-                        continue;
-                    }
-                    final List<Double> l = new ArrayList<Double>();
-                    for( int col = 1; col < t.getNumberOfColumns(); ++col ) {
-                        double d = -100;
-                        try {
-                            d = Double.parseDouble( t.getValueAsString( col, row ) );
-                        }
-                        catch ( final NumberFormatException e ) {
-                            JOptionPane.showMessageDialog( this,
-                                                           "Could not parse \"" + t.getValueAsString( col, row )
-                                                                   + "\" into a decimal value",
-                                                           "Issue with Expression Value Table",
-                                                           JOptionPane.ERROR_MESSAGE );
-                            return;
-                        }
-                        stats.addValue( d );
-                        l.add( d );
-                    }
-                    if ( !l.isEmpty() ) {
-                        if ( node.getNodeData().getProperties() != null ) {
-                            node.getNodeData().getProperties()
-                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );
-                        }
-                        node.getNodeData().setVector( l );
-                    }
-                }
-            }
-            if ( not_found > 0 ) {
-                JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found
-                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );
-            }
-            getCurrentTreePanel().setStatisticsForExpressionValues( stats );
-        }
-    }
-
-    private void addSequencesFromFile() {
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {
-            JOptionPane.showMessageDialog( this,
-                                           "Need to load evolutionary tree first",
-                                           "Can Not Read Sequences",
-                                           JOptionPane.WARNING_MESSAGE );
-            return;
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _sequences_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _sequences_filechooser.showOpenDialog( _contentpane );
-        final File file = _sequences_filechooser.getSelectedFile();
-        List<Sequence> seqs = null;
-        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            try {
-                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {
-                    seqs = FastaParser.parse( new FileInputStream( file ) );
-                }
-                else {
-                    JOptionPane.showMessageDialog( this,
-                                                   "Format does not appear to be Fasta",
-                                                   "Multiple sequence file format error",
-                                                   JOptionPane.ERROR_MESSAGE );
-                    return;
-                }
-            }
-            catch ( final MsaFormatException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Multiple sequence file format error",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final IOException e ) {
-                setArrowCursor();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Failed to read multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            catch ( final Exception e ) {
-                setArrowCursor();
-                e.printStackTrace();
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "Unexpected error during reading of multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                return;
-            }
-            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Multiple sequence file is empty",
-                                               "Empty multiple sequence file",
-                                               JOptionPane.ERROR_MESSAGE );
-                setArrowCursor();
-                return;
-            }
-        }
-        if ( seqs != null ) {
-            for( final Sequence seq : seqs ) {
-                System.out.println( seq.getIdentifier() );
-            }
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            int total_counter = 0;
-            int attached_counter = 0;
-            for( final Sequence seq : seqs ) {
-                ++total_counter;
-                final String seq_name = seq.getIdentifier();
-                if ( !ForesterUtil.isEmpty( seq_name ) ) {
-                    List<PhylogenyNode> nodes = phy.getNodesViaSequenceName( seq_name );
-                    if ( nodes.isEmpty() ) {
-                        nodes = phy.getNodesViaSequenceSymbol( seq_name );
-                    }
-                    if ( nodes.isEmpty() ) {
-                        nodes = phy.getNodesViaGeneName( seq_name );
-                    }
-                    if ( nodes.isEmpty() ) {
-                        nodes = phy.getNodes( seq_name );
-                    }
-                    if ( nodes.size() > 1 ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Sequence name \"" + seq_name + "\" is not unique",
-                                                       "Sequence name not unique",
-                                                       JOptionPane.ERROR_MESSAGE );
-                        setArrowCursor();
-                        return;
-                    }
-                    final String[] a = seq_name.split( "\\s" );
-                    if ( nodes.isEmpty() && ( a.length > 1 ) ) {
-                        final String seq_name_split = a[ 0 ];
-                        nodes = phy.getNodesViaSequenceName( seq_name_split );
-                        if ( nodes.isEmpty() ) {
-                            nodes = phy.getNodesViaSequenceSymbol( seq_name_split );
-                        }
-                        if ( nodes.isEmpty() ) {
-                            nodes = phy.getNodes( seq_name_split );
-                        }
-                        if ( nodes.size() > 1 ) {
-                            JOptionPane.showMessageDialog( this, "Split sequence name \"" + seq_name_split
-                                    + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );
-                            setArrowCursor();
-                            return;
-                        }
-                    }
-                    if ( nodes.size() == 1 ) {
-                        ++attached_counter;
-                        final PhylogenyNode n = nodes.get( 0 );
-                        if ( !n.getNodeData().isHasSequence() ) {
-                            n.getNodeData().addSequence( new org.forester.phylogeny.data.Sequence() );
-                        }
-                        n.getNodeData().getSequence().setMolecularSequence( seq.getMolecularSequenceAsString() );
-                        if ( ForesterUtil.isEmpty( n.getNodeData().getSequence().getName() ) ) {
-                            n.getNodeData().getSequence().setName( seq_name );
-                        }
-                    }
-                }
-            }
-            if ( attached_counter > 0 ) {
-                int ext_nodes = 0;
-                int ext_nodes_with_seq = 0;
-                for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {
-                    ++ext_nodes;
-                    final PhylogenyNode n = iter.next();
-                    if ( n.getNodeData().isHasSequence()
-                            && !ForesterUtil.isEmpty( n.getNodeData().getSequence().getMolecularSequence() ) ) {
-                        ++ext_nodes_with_seq;
-                    }
-                }
-                final String s;
-                if ( ext_nodes == ext_nodes_with_seq ) {
-                    s = "All " + ext_nodes_with_seq + " external nodes now have a molecular sequence attached to them.";
-                }
-                else {
-                    s = ext_nodes_with_seq + " out of " + ext_nodes
-                            + " external nodes now have a molecular sequence attached to them.";
-                }
-                if ( ( attached_counter == total_counter ) && ( ext_nodes == ext_nodes_with_seq ) ) {
-                    JOptionPane.showMessageDialog( this,
-                                                   "Attached all " + total_counter + " sequences to tree nodes.\n" + s,
-                                                   "All sequences attached",
-                                                   JOptionPane.INFORMATION_MESSAGE );
-                }
-                else {
-                    JOptionPane.showMessageDialog( this, "Attached " + attached_counter
-                            + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter
-                            + " sequences attached", JOptionPane.WARNING_MESSAGE );
-                }
-            }
-            else {
-                JOptionPane.showMessageDialog( this, "No maching tree node for any of the " + total_counter
-                        + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );
-            }
-        }
-    }
-
-    private void choosePdfWidth() {
-        final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                 "Please enter the default line width for PDF export.\n"
-                                                                         + "[current value: "
-                                                                         + getOptions().getPrintLineWidth() + "]\n",
-                                                                 "Line Width for PDF Export",
-                                                                 JOptionPane.QUESTION_MESSAGE,
-                                                                 null,
-                                                                 null,
-                                                                 getOptions().getPrintLineWidth() );
-        if ( !ForesterUtil.isEmpty( s ) ) {
-            boolean success = true;
-            float f = 0.0f;
-            final String m_str = s.trim();
-            if ( !ForesterUtil.isEmpty( m_str ) ) {
-                try {
-                    f = Float.parseFloat( m_str );
-                }
-                catch ( final Exception ex ) {
-                    success = false;
-                }
-            }
-            else {
-                success = false;
-            }
-            if ( success && ( f > 0.0 ) ) {
-                getOptions().setPrintLineWidth( f );
-            }
-        }
-    }
-
-    private void choosePrintSize() {
-        final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                 "Please enter values for width and height,\nseparated by a comma.\n"
-                                                                         + "[current values: "
-                                                                         + getOptions().getPrintSizeX() + ", "
-                                                                         + getOptions().getPrintSizeY() + "]\n"
-                                                                         + "[A4: " + Constants.A4_SIZE_X + ", "
-                                                                         + Constants.A4_SIZE_Y + "]\n" + "[US Letter: "
-                                                                         + Constants.US_LETTER_SIZE_X + ", "
-                                                                         + Constants.US_LETTER_SIZE_Y + "]",
-                                                                 "Default Size for Graphics Export",
-                                                                 JOptionPane.QUESTION_MESSAGE,
-                                                                 null,
-                                                                 null,
-                                                                 getOptions().getPrintSizeX() + ", "
-                                                                         + getOptions().getPrintSizeY() );
-        if ( !ForesterUtil.isEmpty( s ) && ( s.indexOf( ',' ) > 0 ) ) {
-            boolean success = true;
-            int x = 0;
-            int y = 0;
-            final String[] str_ary = s.split( "," );
-            if ( str_ary.length == 2 ) {
-                final String x_str = str_ary[ 0 ].trim();
-                final String y_str = str_ary[ 1 ].trim();
-                if ( !ForesterUtil.isEmpty( x_str ) && !ForesterUtil.isEmpty( y_str ) ) {
-                    try {
-                        x = Integer.parseInt( x_str );
-                        y = Integer.parseInt( y_str );
-                    }
-                    catch ( final Exception ex ) {
-                        success = false;
-                    }
-                }
-                else {
-                    success = false;
-                }
-            }
-            else {
-                success = false;
-            }
-            if ( success && ( x > 1 ) && ( y > 1 ) ) {
-                getOptions().setPrintSizeX( x );
-                getOptions().setPrintSizeY( y );
-            }
-        }
-    }
-
-    private void closeCurrentPane() {
-        if ( getMainPanel().getCurrentTreePanel() != null ) {
-            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {
-                final int r = JOptionPane.showConfirmDialog( this,
-                                                             "Close tab despite potentially unsaved changes?",
-                                                             "Close Tab?",
-                                                             JOptionPane.YES_NO_OPTION );
-                if ( r != JOptionPane.YES_OPTION ) {
-                    return;
-                }
-            }
-            getMainPanel().closeCurrentPane();
-            activateSaveAllIfNeeded();
-        }
-    }
-
-    private void collapse( final Phylogeny phy, final double m ) {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();
-        double min_support = Double.MAX_VALUE;
-        boolean conf_present = false;
-        while ( it.hasNext() ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.isExternal() && !n.isRoot() ) {
-                final List<Confidence> c = n.getBranchData().getConfidences();
-                if ( ( c != null ) && ( c.size() > 0 ) ) {
-                    conf_present = true;
-                    double max = 0;
-                    for( final Confidence confidence : c ) {
-                        if ( confidence.getValue() > max ) {
-                            max = confidence.getValue();
-                        }
-                    }
-                    if ( max < getMinNotCollapseConfidenceValue() ) {
-                        to_be_removed.add( n );
-                    }
-                    if ( max < min_support ) {
-                        min_support = max;
-                    }
-                }
-            }
-        }
-        if ( conf_present ) {
-            for( final PhylogenyNode node : to_be_removed ) {
-                PhylogenyMethods.removeNode( node, phy );
-            }
-            if ( to_be_removed.size() > 0 ) {
-                phy.externalNodesHaveChanged();
-                phy.clearHashIdToNodeMap();
-                phy.recalculateNumberOfExternalDescendants( true );
-                getCurrentTreePanel().resetNodeIdToDistToLeafMap();
-                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();
-                getCurrentTreePanel().calculateLongestExtNodeInfo();
-                getCurrentTreePanel().setNodeInPreorderToNull();
-                getCurrentTreePanel().recalculateMaxDistanceToRoot();
-                getCurrentTreePanel().resetPreferredSize();
-                getCurrentTreePanel().setEdited( true );
-                getCurrentTreePanel().repaint();
-                repaint();
-            }
-            if ( to_be_removed.size() > 0 ) {
-                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()
-                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "
-                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );
-            }
-            else {
-                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "
-                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );
-            }
-        }
-        else {
-            JOptionPane.showMessageDialog( this,
-                                           "No branch collapsed because no confidence values present",
-                                           "No confidence values present",
-                                           JOptionPane.INFORMATION_MESSAGE );
-        }
-    }
-
-    private void collapseBelowThreshold() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final String s = ( String ) JOptionPane.showInputDialog( this,
-                                                                         "Please enter the minimum confidence value\n",
-                                                                         "Minimal Confidence Value",
-                                                                         JOptionPane.QUESTION_MESSAGE,
-                                                                         null,
-                                                                         null,
-                                                                         getMinNotCollapseConfidenceValue() );
-                if ( !ForesterUtil.isEmpty( s ) ) {
-                    boolean success = true;
-                    double m = 0.0;
-                    final String m_str = s.trim();
-                    if ( !ForesterUtil.isEmpty( m_str ) ) {
-                        try {
-                            m = Double.parseDouble( m_str );
-                        }
-                        catch ( final Exception ex ) {
-                            success = false;
-                        }
-                    }
-                    else {
-                        success = false;
-                    }
-                    if ( success && ( m >= 0.0 ) ) {
-                        setMinNotCollapseConfidenceValue( m );
-                        collapse( phy, m );
-                    }
-                }
-            }
-        }
-    }
-
-    private PhyloXmlParser createPhyloXmlParser() {
-        PhyloXmlParser xml_parser = null;
-        if ( getConfiguration().isValidatePhyloXmlAgainstSchema() ) {
-            try {
-                xml_parser = PhyloXmlParser.createPhyloXmlParserXsdValidating();
-            }
-            catch ( final Exception e ) {
-                JOptionPane.showMessageDialog( this,
-                                               e.getLocalizedMessage(),
-                                               "failed to create validating XML parser",
-                                               JOptionPane.WARNING_MESSAGE );
-            }
-        }
-        if ( xml_parser == null ) {
-            xml_parser = PhyloXmlParser.createPhyloXmlParser();
-        }
-        return xml_parser;
-    }
-
-    private void executePhyleneticInference( final boolean from_unaligned_seqs ) {
-        final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,
-                                                                      getPhylogeneticInferenceOptions(),
-                                                                      from_unaligned_seqs );
-        dialog.activate();
-        if ( dialog.getValue() == JOptionPane.OK_OPTION ) {
-            if ( !from_unaligned_seqs ) {
-                if ( getMsa() != null ) {
-                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getMsa(),
-                                                                                    getPhylogeneticInferenceOptions()
-                                                                                            .copy(), this );
-                    new Thread( inferrer ).start();
-                }
-                else {
-                    JOptionPane.showMessageDialog( this,
-                                                   "No multiple sequence alignment selected",
-                                                   "Phylogenetic Inference Not Launched",
-                                                   JOptionPane.WARNING_MESSAGE );
-                }
-            }
-            else {
-                if ( getSeqs() != null ) {
-                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getSeqs(),
-                                                                                    getPhylogeneticInferenceOptions()
-                                                                                            .copy(), this );
-                    new Thread( inferrer ).start();
-                }
-                else {
-                    JOptionPane.showMessageDialog( this,
-                                                   "No input sequences selected",
-                                                   "Phylogenetic Inference Not Launched",
-                                                   JOptionPane.WARNING_MESSAGE );
-                }
-            }
-        }
-    }
-
-    private void extractTaxDataFromNodeNames() throws PhyloXmlDataFormatException {
-        final StringBuilder sb = new StringBuilder();
-        final StringBuilder sb_failed = new StringBuilder();
-        int counter = 0;
-        int counter_failed = 0;
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final PhylogenyNodeIterator it = phy.iteratorExternalForward();
-                while ( it.hasNext() ) {
-                    final PhylogenyNode n = it.next();
-                    final String name = n.getName().trim();
-                    if ( !ForesterUtil.isEmpty( name ) ) {
-                        final String nt = ParserUtils.extractTaxonomyDataFromNodeName( n,
-                                                                                       TAXONOMY_EXTRACTION.AGGRESSIVE );
-                        if ( !ForesterUtil.isEmpty( nt ) ) {
-                            if ( counter < 15 ) {
-                                sb.append( name + ": " + nt + "\n" );
-                            }
-                            else if ( counter == 15 ) {
-                                sb.append( "...\n" );
-                            }
-                            counter++;
-                        }
-                        else {
-                            if ( counter_failed < 15 ) {
-                                sb_failed.append( name + "\n" );
-                            }
-                            else if ( counter_failed == 15 ) {
-                                sb_failed.append( "...\n" );
-                            }
-                            counter_failed++;
-                        }
-                    }
-                }
-                if ( counter > 0 ) {
-                    String failed = "";
-                    String all = "all ";
-                    if ( counter_failed > 0 ) {
-                        all = "";
-                        failed = "\nCould not extract taxonomic data for " + counter_failed
-                                + " named external nodes:\n" + sb_failed;
-                    }
-                    JOptionPane.showMessageDialog( this,
-                                                   "Extracted taxonomic data from " + all + counter
-                                                           + " named external nodes:\n" + sb.toString() + failed,
-                                                   "Taxonomic Data Extraction Completed",
-                                                   counter_failed > 0 ? JOptionPane.WARNING_MESSAGE
-                                                           : JOptionPane.INFORMATION_MESSAGE );
-                }
-                else {
-                    JOptionPane
-                            .showMessageDialog( this,
-                                                "Could not extract any taxonomic data.\nMaybe node names are empty\n"
-                                                        + "or not in the forms \"XYZ_CAEEL\", \"XYZ_6239\", or \"XYZ_Caenorhabditis_elegans\"\n"
-                                                        + "or nodes already have taxonomic data?\n",
-                                                "No Taxonomic Data Extracted",
-                                                JOptionPane.ERROR_MESSAGE );
-                }
-            }
-        }
-    }
-
-    private ControlPanel getControlPanel() {
-        return getMainPanel().getControlPanel();
-    }
-
-    private File getCurrentDir() {
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {
-            if ( ForesterUtil.isWindows() ) {
-                try {
-                    _current_dir = new File( WindowsUtils.getCurrentUserDesktopPath() );
-                }
-                catch ( final Exception e ) {
-                    _current_dir = null;
-                }
-            }
-        }
-        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {
-            if ( System.getProperty( "user.home" ) != null ) {
-                _current_dir = new File( System.getProperty( "user.home" ) );
-            }
-            else if ( System.getProperty( "user.dir" ) != null ) {
-                _current_dir = new File( System.getProperty( "user.dir" ) );
-            }
-        }
-        return _current_dir;
-    }
-
-    private double getMinNotCollapseConfidenceValue() {
-        return _min_not_collapse;
-    }
-
-    private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {
-        if ( _phylogenetic_inference_options == null ) {
-            _phylogenetic_inference_options = new PhylogeneticInferenceOptions();
-        }
-        return _phylogenetic_inference_options;
-    }
-
-    private boolean isUnsavedDataPresent() {
-        final List<TreePanel> tps = getMainPanel().getTreePanels();
-        for( final TreePanel tp : tps ) {
-            if ( tp.isEdited() ) {
-                return true;
-            }
-        }
-        return false;
-    }
-
-    private void moveNodeNamesToSeqNames() throws PhyloXmlDataFormatException {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                PhylogenyMethods
-                        .transferNodeNameToField( phy, PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME, false );
-            }
-        }
-    }
-
-    private void moveNodeNamesToTaxSn() throws PhyloXmlDataFormatException {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                PhylogenyMethods.transferNodeNameToField( phy,
-                                                          PhylogenyMethods.PhylogenyNodeField.TAXONOMY_SCIENTIFIC_NAME,
-                                                          false );
-            }
-        }
-    }
-
-    private void newTree() {
-        final Phylogeny[] phys = new Phylogeny[ 1 ];
-        final Phylogeny phy = new Phylogeny();
-        final PhylogenyNode node = new PhylogenyNode();
-        phy.setRoot( node );
-        phy.setRooted( true );
-        phys[ 0 ] = phy;
-        AptxUtil.addPhylogeniesToTabs( phys, "", "", getConfiguration(), getMainPanel() );
-        _mainpanel.getControlPanel().showWhole();
-        _mainpanel.getCurrentTreePanel().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        _mainpanel.getOptions().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        if ( getMainPanel().getMainFrame() == null ) {
-            // Must be "E" applet version.
-            ( ( ArchaeopteryxE ) ( ( MainPanelApplets ) getMainPanel() ).getApplet() )
-                    .setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        }
-        else {
-            getMainPanel().getMainFrame().setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );
-        }
-        activateSaveAllIfNeeded();
-        System.gc();
-    }
-
-    private void obtainDetailedTaxonomicInformation() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final TaxonomyDataManager t = new TaxonomyDataManager( this,
-                                                                       _mainpanel.getCurrentTreePanel(),
-                                                                       phy.copy(),
-                                                                       false,
-                                                                       true );
-                new Thread( t ).start();
-            }
-        }
-    }
-
-    private void obtainDetailedTaxonomicInformationDelete() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final TaxonomyDataManager t = new TaxonomyDataManager( this,
-                                                                       _mainpanel.getCurrentTreePanel(),
-                                                                       phy.copy(),
-                                                                       true,
-                                                                       true );
-                new Thread( t ).start();
-            }
-        }
-    }
-
-    private void obtainSequenceInformation() {
-        if ( getCurrentTreePanel() != null ) {
-            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();
-            if ( ( phy != null ) && !phy.isEmpty() ) {
-                final SequenceDataRetriver u = new SequenceDataRetriver( this,
-                                                                         _mainpanel.getCurrentTreePanel(),
-                                                                         phy.copy() );
-                new Thread( u ).start();
-            }
-        }
-    }
-
-    private void print() {
-        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null )
-                || getCurrentTreePanel().getPhylogeny().isEmpty() ) {
-            return;
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX() - 80,
-                                                             getOptions().getPrintSizeY() - 140,
-                                                             true );
-            getCurrentTreePanel().resetPreferredSize();
-            getCurrentTreePanel().repaint();
-        }
-        final String job_name = Constants.PRG_NAME;
-        boolean error = false;
-        String printer_name = null;
-        try {
-            printer_name = Printer.print( getCurrentTreePanel(), job_name );
-        }
-        catch ( final Exception e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Printing Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error && ( printer_name != null ) ) {
-            String msg = "Printing data sent to printer";
-            if ( printer_name.length() > 1 ) {
-                msg += " [" + printer_name + "]";
-            }
-            JOptionPane.showMessageDialog( this, msg, "Printing...", JOptionPane.INFORMATION_MESSAGE );
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getControlPanel().showWhole();
-        }
-    }
-
-    private void printPhylogenyToPdf( final String file_name ) {
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX(),
-                                                             getOptions().getPrintSizeY(),
-                                                             true );
-            getCurrentTreePanel().resetPreferredSize();
-            getCurrentTreePanel().repaint();
-        }
-        String pdf_written_to = "";
-        boolean error = false;
-        try {
-            if ( getOptions().isPrintUsingActualSize() ) {
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name,
-                                                                  getCurrentTreePanel(),
-                                                                  getCurrentTreePanel().getWidth(),
-                                                                  getCurrentTreePanel().getHeight() );
-            }
-            else {
-                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name, getCurrentTreePanel(), getOptions()
-                        .getPrintSizeX(), getOptions().getPrintSizeY() );
-            }
-        }
-        catch ( final IOException e ) {
-            error = true;
-            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );
-        }
-        if ( !error ) {
-            if ( !ForesterUtil.isEmpty( pdf_written_to ) ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Wrote PDF to: " + pdf_written_to,
-                                               "Information",
-                                               JOptionPane.INFORMATION_MESSAGE );
-            }
-            else {
-                JOptionPane.showMessageDialog( this,
-                                               "There was an unknown problem when attempting to write to PDF file: \""
-                                                       + file_name + "\"",
-                                               "Error",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-        }
-        if ( !getOptions().isPrintUsingActualSize() ) {
-            getControlPanel().showWhole();
-        }
-    }
-
-    private void readPhylogeniesFromFile() {
-        boolean exception = false;
-        Phylogeny[] phys = null;
-        // Set an initial directory if none set yet
-        final File my_dir = getCurrentDir();
-        _open_filechooser.setMultiSelectionEnabled( true );
-        // Open file-open dialog and set current directory
-        if ( my_dir != null ) {
-            _open_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _open_filechooser.showOpenDialog( _contentpane );
-        // All done: get the file
-        final File[] files = _open_filechooser.getSelectedFiles();
-        setCurrentDir( _open_filechooser.getCurrentDirectory() );
-        boolean nhx_or_nexus = false;
-        if ( ( files != null ) && ( files.length > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            for( final File file : files ) {
-                if ( ( file != null ) && !file.isDirectory() ) {
-                    if ( _mainpanel.getCurrentTreePanel() != null ) {
-                        _mainpanel.getCurrentTreePanel().setWaitCursor();
-                    }
-                    else {
-                        _mainpanel.setWaitCursor();
-                    }
-                    if ( ( _open_filechooser.getFileFilter() == MainFrameApplication.nhfilter )
-                            || ( _open_filechooser.getFileFilter() == MainFrameApplication.nhxfilter ) ) {
-                        try {
-                            final NHXParser nhx = new NHXParser();
-                            setSpecialOptionsForNhxParser( nhx );
-                            phys = PhylogenyMethods.readPhylogenies( nhx, file );
-                            nhx_or_nexus = true;
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                        warnIfNotPhyloXmlValidation( getConfiguration() );
-                        try {
-                            final PhyloXmlParser xml_parser = createPhyloXmlParser();
-                            phys = PhylogenyMethods.readPhylogenies( xml_parser, file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.tolfilter ) {
-                        try {
-                            phys = PhylogenyMethods.readPhylogenies( new TolParser(), file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {
-                        try {
-                            final NexusPhylogeniesParser nex = new NexusPhylogeniesParser();
-                            setSpecialOptionsForNexParser( nex );
-                            phys = PhylogenyMethods.readPhylogenies( nex, file );
-                            nhx_or_nexus = true;
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    // "*.*":
-                    else {
-                        try {
-                            final PhylogenyParser parser = ParserUtils
-                                    .createParserDependingOnFileType( file, getConfiguration()
-                                            .isValidatePhyloXmlAgainstSchema() );
-                            if ( parser instanceof NexusPhylogeniesParser ) {
-                                final NexusPhylogeniesParser nex = ( NexusPhylogeniesParser ) parser;
-                                setSpecialOptionsForNexParser( nex );
-                                nhx_or_nexus = true;
-                            }
-                            else if ( parser instanceof NHXParser ) {
-                                final NHXParser nhx = ( NHXParser ) parser;
-                                setSpecialOptionsForNhxParser( nhx );
-                                nhx_or_nexus = true;
-                            }
-                            else if ( parser instanceof PhyloXmlParser ) {
-                                warnIfNotPhyloXmlValidation( getConfiguration() );
-                            }
-                            phys = PhylogenyMethods.readPhylogenies( parser, file );
-                        }
-                        catch ( final Exception e ) {
-                            exception = true;
-                            exceptionOccuredDuringOpenFile( e );
-                        }
-                    }
-                    if ( _mainpanel.getCurrentTreePanel() != null ) {
-                        _mainpanel.getCurrentTreePanel().setArrowCursor();
-                    }
-                    else {
-                        _mainpanel.setArrowCursor();
-                    }
-                    if ( !exception && ( phys != null ) && ( phys.length > 0 ) ) {
-                        boolean one_desc = false;
-                        if ( nhx_or_nexus ) {
-                            for( final Phylogeny phy : phys ) {
-                                if ( getOptions().isInternalNumberAreConfidenceForNhParsing() ) {
-                                    PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );
-                                }
-                                if ( PhylogenyMethods.getMinimumDescendentsPerInternalNodes( phy ) == 1 ) {
-                                    one_desc = true;
-                                    break;
-                                }
-                            }
-                        }
-                        AptxUtil.addPhylogeniesToTabs( phys,
-                                                       file.getName(),
-                                                       file.getAbsolutePath(),
-                                                       getConfiguration(),
-                                                       getMainPanel() );
-                        _mainpanel.getControlPanel().showWhole();
-                        if ( nhx_or_nexus && one_desc ) {
-                            JOptionPane
-                                    .showMessageDialog( this,
-                                                        "One or more trees contain (a) node(s) with one descendant, "
-                                                                + ForesterUtil.LINE_SEPARATOR
-                                                                + "possibly indicating illegal parentheses within node names.",
-                                                        "Warning: Possible Error in New Hampshire Formatted Data",
-                                                        JOptionPane.WARNING_MESSAGE );
-                        }
-                    }
-                }
-            }
-        }
-        activateSaveAllIfNeeded();
-        System.gc();
-    }
-
-    private void readSpeciesTreeFromFile() {
-        Phylogeny t = null;
-        boolean exception = false;
-        final File my_dir = getCurrentDir();
-        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );
-        if ( my_dir != null ) {
-            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );
-        }
-        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );
-        final File file = _open_filechooser_for_species_tree.getSelectedFile();
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser
-                            .createPhyloXmlParserXsdValidating(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
-                }
-            }
-            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.tolfilter ) {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
-                }
-            }
-            // "*.*":
-            else {
-                try {
-                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser
-                            .createPhyloXmlParserXsdValidating(), file );
-                    t = trees[ 0 ];
-                }
-                catch ( final Exception e ) {
-                    exception = true;
-                    exceptionOccuredDuringOpenFile( e );
-                }
-            }
-            if ( !exception && ( t != null ) && !t.isRooted() ) {
-                exception = true;
-                t = null;
-                JOptionPane.showMessageDialog( this,
-                                               "Species tree is not rooted",
-                                               "Species tree not loaded",
-                                               JOptionPane.ERROR_MESSAGE );
-            }
-            if ( !exception && ( t != null ) ) {
-                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();
-                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {
-                    final PhylogenyNode node = it.next();
-                    if ( !node.getNodeData().isHasTaxonomy() ) {
-                        exception = true;
-                        t = null;
-                        JOptionPane
-                                .showMessageDialog( this,
-                                                    "Species tree contains external node(s) without taxonomy information",
-                                                    "Species tree not loaded",
-                                                    JOptionPane.ERROR_MESSAGE );
-                        break;
-                    }
-                    else {
-                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {
-                            exception = true;
-                            t = null;
-                            JOptionPane.showMessageDialog( this,
-                                                           "Taxonomy ["
-                                                                   + node.getNodeData().getTaxonomy().asSimpleText()
-                                                                   + "] is not unique in species tree",
-                                                           "Species tree not loaded",
-                                                           JOptionPane.ERROR_MESSAGE );
-                            break;
-                        }
-                        else {
-                            tax_set.add( node.getNodeData().getTaxonomy() );
-                        }
-                    }
-                }
-            }
-            if ( !exception && ( t != null ) ) {
-                setSpeciesTree( t );
-                JOptionPane.showMessageDialog( this,
-                                               "Species tree successfully loaded",
-                                               "Species tree loaded",
-                                               JOptionPane.INFORMATION_MESSAGE );
-            }
-            _contentpane.repaint();
-            System.gc();
-        }
-    }
-
-    private void setArrowCursor() {
-        try {
-            _mainpanel.getCurrentTreePanel().setArrowCursor();
-        }
-        catch ( final Exception ex ) {
-            // Do nothing.
-        }
-    }
-
-    private void setCurrentDir( final File current_dir ) {
-        _current_dir = current_dir;
-    }
-
-    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {
-        _min_not_collapse = min_not_collapse;
-    }
-
-    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {
-        _phylogenetic_inference_options = phylogenetic_inference_options;
-    }
-
-    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {
-        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
-        nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );
-    }
-
-    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {
-        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );
-        nhx.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );
-        nhx.setAllowErrorsInDistanceToParent( getOptions().isAllowErrorsInDistanceToParent() );
-    }
-
-    private void writeAllToFile() {
-        if ( ( getMainPanel().getTabbedPane() == null ) || ( getMainPanel().getTabbedPane().getTabCount() < 1 ) ) {
-            return;
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _save_filechooser.setCurrentDirectory( my_dir );
-        }
-        _save_filechooser.setSelectedFile( new File( "" ) );
-        final int result = _save_filechooser.showSaveDialog( _contentpane );
-        final File file = _save_filechooser.getSelectedFile();
-        setCurrentDir( _save_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "Warning",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
-                }
-                else {
-                    try {
-                        file.delete();
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Error",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
-                }
-            }
-            final int count = getMainPanel().getTabbedPane().getTabCount();
-            final List<Phylogeny> trees = new ArrayList<Phylogeny>();
-            for( int i = 0; i < count; ++i ) {
-                final Phylogeny phy = getMainPanel().getPhylogeny( i );
-                if ( ForesterUtil.isEmpty( phy.getName() )
-                        && !ForesterUtil.isEmpty( getMainPanel().getTabbedPane().getTitleAt( i ) ) ) {
-                    phy.setName( getMainPanel().getTabbedPane().getTitleAt( i ) );
-                }
-                trees.add( phy );
-                getMainPanel().getTreePanels().get( i ).setEdited( false );
-            }
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            try {
-                writer.toPhyloXML( file, trees, 0, ForesterUtil.LINE_SEPARATOR );
-            }
-            catch ( final IOException e ) {
-                JOptionPane.showMessageDialog( this,
-                                               "Failed to write to: " + file,
-                                               "Error",
-                                               JOptionPane.WARNING_MESSAGE );
-            }
-        }
-    }
-
-    private boolean writeAsNewHampshire( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toNewHampshire( t, true, getOptions().getNhConversionSupportValueStyle(), file );
-        }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
-        }
-        return exception;
-    }
-
-    private boolean writeAsNexus( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toNexus( file, t, getOptions().getNhConversionSupportValueStyle() );
-        }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
-        }
-        return exception;
-    }
-
-    private boolean writeAsPhyloXml( final Phylogeny t, boolean exception, final File file ) {
-        try {
-            final PhylogenyWriter writer = new PhylogenyWriter();
-            writer.toPhyloXML( file, t, 0 );
-        }
-        catch ( final Exception e ) {
-            exception = true;
-            exceptionOccuredDuringSaveAs( e );
-        }
-        return exception;
-    }
-
-    private void writeToFile( final Phylogeny t ) {
-        if ( t == null ) {
-            return;
-        }
-        String initial_filename = null;
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
-            try {
-                initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().getCanonicalPath();
-            }
-            catch ( final IOException e ) {
-                initial_filename = null;
-            }
-        }
-        if ( !ForesterUtil.isEmpty( initial_filename ) ) {
-            _save_filechooser.setSelectedFile( new File( initial_filename ) );
-        }
-        else {
-            _save_filechooser.setSelectedFile( new File( "" ) );
-        }
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _save_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _save_filechooser.showSaveDialog( _contentpane );
-        final File file = _save_filechooser.getSelectedFile();
-        setCurrentDir( _save_filechooser.getCurrentDirectory() );
-        boolean exception = false;
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists.\nOverwrite?",
-                                                             "Overwrite?",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.QUESTION_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
-                }
-                else {
-                    final File to = new File( file.getAbsoluteFile().toString() + Constants.BACKUP_FILE_SUFFIX );
-                    try {
-                        ForesterUtil.copyFile( file, to );
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to create backup copy " + to,
-                                                       "Failed to Create Backup Copy",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
-                    try {
-                        file.delete();
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Failed to Delete",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
-                }
-            }
-            if ( _save_filechooser.getFileFilter() == MainFrameApplication.nhfilter ) {
-                exception = writeAsNewHampshire( t, exception, file );
-            }
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {
-                exception = writeAsPhyloXml( t, exception, file );
-            }
-            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {
-                exception = writeAsNexus( t, exception, file );
-            }
-            // "*.*":
-            else {
-                final String file_name = file.getName().trim().toLowerCase();
-                if ( file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                        || file_name.endsWith( ".tree" ) ) {
-                    exception = writeAsNewHampshire( t, exception, file );
-                }
-                else if ( file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) ) {
-                    exception = writeAsNexus( t, exception, file );
-                }
-                // XML is default:
-                else {
-                    exception = writeAsPhyloXml( t, exception, file );
-                }
-            }
-            if ( !exception ) {
-                getMainPanel().setTitleOfSelectedTab( file.getName() );
-                getMainPanel().getCurrentTreePanel().setTreeFile( file );
-                getMainPanel().getCurrentTreePanel().setEdited( false );
-            }
-        }
-    }
-
-    private void writeToGraphicsFile( final Phylogeny t, final GraphicsExportType type ) {
-        if ( ( t == null ) || t.isEmpty() ) {
-            return;
-        }
-        String initial_filename = "";
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();
-        }
-        if ( initial_filename.indexOf( '.' ) > 0 ) {
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );
-        }
-        initial_filename = initial_filename + "." + type;
-        _writetographics_filechooser.setSelectedFile( new File( initial_filename ) );
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _writetographics_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _writetographics_filechooser.showSaveDialog( _contentpane );
-        File file = _writetographics_filechooser.getSelectedFile();
-        setCurrentDir( _writetographics_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( !file.toString().toLowerCase().endsWith( type.toString() ) ) {
-                file = new File( file.toString() + "." + type );
-            }
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "Warning",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
-                }
-                else {
-                    try {
-                        file.delete();
-                    }
-                    catch ( final Exception e ) {
-                        JOptionPane.showMessageDialog( this,
-                                                       "Failed to delete: " + file,
-                                                       "Error",
-                                                       JOptionPane.WARNING_MESSAGE );
-                    }
-                }
-            }
-            writePhylogenyToGraphicsFile( file.toString(), type );
-        }
-    }
-
-    private void writeToPdf( final Phylogeny t ) {
-        if ( ( t == null ) || t.isEmpty() ) {
-            return;
-        }
-        String initial_filename = "";
-        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {
-            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();
-        }
-        if ( initial_filename.indexOf( '.' ) > 0 ) {
-            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );
-        }
-        initial_filename = initial_filename + ".pdf";
-        _writetopdf_filechooser.setSelectedFile( new File( initial_filename ) );
-        final File my_dir = getCurrentDir();
-        if ( my_dir != null ) {
-            _writetopdf_filechooser.setCurrentDirectory( my_dir );
-        }
-        final int result = _writetopdf_filechooser.showSaveDialog( _contentpane );
-        File file = _writetopdf_filechooser.getSelectedFile();
-        setCurrentDir( _writetopdf_filechooser.getCurrentDirectory() );
-        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {
-            if ( !file.toString().toLowerCase().endsWith( ".pdf" ) ) {
-                file = new File( file.toString() + ".pdf" );
-            }
-            if ( file.exists() ) {
-                final int i = JOptionPane.showConfirmDialog( this,
-                                                             file + " already exists. Overwrite?",
-                                                             "WARNING",
-                                                             JOptionPane.OK_CANCEL_OPTION,
-                                                             JOptionPane.WARNING_MESSAGE );
-                if ( i != JOptionPane.OK_OPTION ) {
-                    return;
-                }
-            }
-            printPhylogenyToPdf( file.toString() );
-        }
-    }
-
-    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {
-        return new MainFrameApplication( phys, config );
-    }
-
-    public static MainFrame createInstance( final Phylogeny[] phys,
-                                            final Configuration config,
-                                            final String title,
-                                            final File current_dir ) {
-        return new MainFrameApplication( phys, config, title, current_dir );
-    }
-
-    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {
-        return new MainFrameApplication( phys, config, title );
-    }
-
-    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {
-        return new MainFrameApplication( phys, config_file_name, title );
-    }
-
-    static void setTextForGraphicsSizeChooserMenuItem( final JMenuItem mi, final Options o ) {
-        mi.setText( "Enter Default Size for Graphics Export... (current: " + o.getPrintSizeX() + ", "
-                + o.getPrintSizeY() + ")" );
-    }
-
-    static void setTextForPdfLineWidthChooserMenuItem( final JMenuItem mi, final Options o ) {
-        mi.setText( "Enter Default Line Width for PDF Export... (current: " + o.getPrintLineWidth() + ")" );
-    }
-
-    static void warnIfNotPhyloXmlValidation( final Configuration c ) {
-        if ( !c.isValidatePhyloXmlAgainstSchema() ) {
-            JOptionPane
-                    .showMessageDialog( null,
-                                        ForesterUtil
-                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",
-                                                           80 ),
-                                        "Warning",
-                                        JOptionPane.WARNING_MESSAGE );
-        }
-    }
-} // MainFrameApplication.
-
-class DefaultFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                || file_name.endsWith( ".nwk" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".ph" )
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".dnd" ) || file_name.endsWith( ".tree" )
-                || file_name.endsWith( ".nhx" ) || file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" )
-                || file_name.endsWith( "phylo.xml" ) || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".nexus" )
-                || file_name.endsWith( ".nx" ) || file_name.endsWith( ".nex" ) || file_name.endsWith( ".tre" )
-                || file_name.endsWith( ".zip" ) || file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" )
-                || file_name.endsWith( ".con" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "All supported files (*.xml, *.phyloxml, *phylo.xml, *.nhx, *.nh, *.newick, *.nex, *.nexus, *.phy, *.tre, *.tree, *.tol, ...)";
-    }
-}
-
-class GraphicsFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".jpg" ) || file_name.endsWith( ".jpeg" ) || file_name.endsWith( ".png" )
-                || file_name.endsWith( ".gif" ) || file_name.endsWith( ".bmp" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Image files (*.jpg, *.jpeg, *.png, *.gif, *.bmp)";
-    }
-}
-
-class MsaFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".msa" ) || file_name.endsWith( ".aln" ) || file_name.endsWith( ".fasta" )
-                || file_name.endsWith( ".fas" ) || file_name.endsWith( ".fa" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Multiple sequence alignment files (*.msa, *.aln, *.fasta, *.fa, *.fas)";
-    }
-}
-
-class NexusFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) || file_name.endsWith( ".nx" )
-                || file_name.endsWith( ".tre" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Nexus files (*.nex, *.nexus, *.nx, *.tre)";
-    }
-} // NexusFilter
-
-class NHFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )
-                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".tree" ) || file_name.endsWith( ".dnd" )
-                || file_name.endsWith( ".ph" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".nwk" )
-                || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "New Hampshire - Newick files (*.nh, *.newick, *.phy, *.tree, *.dnd, *.tr, *.ph, *.phb, *.nwk)";
-    }
-} // NHFilter
-
-class NHXFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".nhx" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "NHX files (*.nhx) [deprecated]";
-    }
-}
-
-class PdfFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        return f.getName().trim().toLowerCase().endsWith( ".pdf" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "PDF files (*.pdf)";
-    }
-} // PdfFilter
-
-class SequencesFileFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".fasta" ) || file_name.endsWith( ".fa" ) || file_name.endsWith( ".fas" )
-                || file_name.endsWith( ".seqs" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "Sequences files (*.fasta, *.fa, *.fas, *.seqs )";
-    }
-}
-
-class TolFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return ( file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" ) || file_name.endsWith( ".zip" ) || f
-                .isDirectory() ) && ( !file_name.endsWith( ".xml.zip" ) );
-    }
-
-    @Override
-    public String getDescription() {
-        return "Tree of Life files (*.tol, *.tolxml)";
-    }
-} // TolFilter
-
-class XMLFilter extends FileFilter {
-
-    @Override
-    public boolean accept( final File f ) {
-        final String file_name = f.getName().trim().toLowerCase();
-        return file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" ) || file_name.endsWith( "phylo.xml" )
-                || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".zip" ) || f.isDirectory();
-    }
-
-    @Override
-    public String getDescription() {
-        return "phyloXML files (*.xml, *.phyloxml, *phylo.xml, *.pxml, *.zip)";
-    }
-} // XMLFilter
+// $Id:\r
+// FORESTER -- software libraries and applications\r
+// for evolutionary biology research and applications.\r
+//\r
+// Copyright (C) 2008-2009 Christian M. Zmasek\r
+// Copyright (C) 2008-2009 Burnham Institute for Medical Research\r
+// Copyright (C) 2003-2007 Ethalinda K.S. Cannon\r
+// All rights reserved\r
+//\r
+// This library is free software; you can redistribute it and/or\r
+// modify it under the terms of the GNU Lesser General Public\r
+// License as published by the Free Software Foundation; either\r
+// version 2.1 of the License, or (at your option) any later version.\r
+//\r
+// This library is distributed in the hope that it will be useful,\r
+// but WITHOUT ANY WARRANTY; without even the implied warranty of\r
+// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU\r
+// Lesser General Public License for more details.\r
+//\r
+// You should have received a copy of the GNU Lesser General Public\r
+// License along with this library; if not, write to the Free Software\r
+// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA\r
+//\r
+// Contact: phylosoft @ gmail . com\r
+// WWW: https://sites.google.com/site/cmzmasek/home/software/forester\r
+\r
+package org.forester.archaeopteryx;\r
+\r
+import java.awt.BorderLayout;\r
+import java.awt.Font;\r
+import java.awt.event.ActionEvent;\r
+import java.awt.event.ComponentAdapter;\r
+import java.awt.event.ComponentEvent;\r
+import java.awt.event.WindowAdapter;\r
+import java.awt.event.WindowEvent;\r
+import java.io.File;\r
+import java.io.FileInputStream;\r
+import java.io.IOException;\r
+import java.io.InputStream;\r
+import java.net.MalformedURLException;\r
+import java.net.URL;\r
+import java.util.ArrayList;\r
+import java.util.HashSet;\r
+import java.util.List;\r
+import java.util.Set;\r
+\r
+import javax.swing.ButtonGroup;\r
+import javax.swing.JCheckBoxMenuItem;\r
+import javax.swing.JFileChooser;\r
+import javax.swing.JMenu;\r
+import javax.swing.JMenuBar;\r
+import javax.swing.JMenuItem;\r
+import javax.swing.JOptionPane;\r
+import javax.swing.JRadioButtonMenuItem;\r
+import javax.swing.UIManager;\r
+import javax.swing.UnsupportedLookAndFeelException;\r
+import javax.swing.WindowConstants;\r
+import javax.swing.event.ChangeEvent;\r
+import javax.swing.event.ChangeListener;\r
+import javax.swing.filechooser.FileFilter;\r
+import javax.swing.plaf.synth.SynthLookAndFeel;\r
+\r
+import org.forester.analysis.TaxonomyDataManager;\r
+import org.forester.archaeopteryx.AptxUtil.GraphicsExportType;\r
+import org.forester.archaeopteryx.Options.CLADOGRAM_TYPE;\r
+import org.forester.archaeopteryx.Options.NODE_LABEL_DIRECTION;\r
+import org.forester.archaeopteryx.Options.PHYLOGENY_GRAPHICS_TYPE;\r
+import org.forester.archaeopteryx.tools.AncestralTaxonomyInferrer;\r
+import org.forester.archaeopteryx.tools.InferenceManager;\r
+import org.forester.archaeopteryx.tools.PhyloInferenceDialog;\r
+import org.forester.archaeopteryx.tools.PhylogeneticInferenceOptions;\r
+import org.forester.archaeopteryx.tools.PhylogeneticInferrer;\r
+import org.forester.archaeopteryx.tools.SequenceDataRetriver;\r
+import org.forester.archaeopteryx.webservices.PhylogeniesWebserviceClient;\r
+import org.forester.archaeopteryx.webservices.WebservicesManager;\r
+import org.forester.io.parsers.FastaParser;\r
+import org.forester.io.parsers.GeneralMsaParser;\r
+import org.forester.io.parsers.PhylogenyParser;\r
+import org.forester.io.parsers.nexus.NexusPhylogeniesParser;\r
+import org.forester.io.parsers.nhx.NHXParser;\r
+import org.forester.io.parsers.nhx.NHXParser.TAXONOMY_EXTRACTION;\r
+import org.forester.io.parsers.phyloxml.PhyloXmlDataFormatException;\r
+import org.forester.io.parsers.phyloxml.PhyloXmlParser;\r
+import org.forester.io.parsers.phyloxml.PhyloXmlUtil;\r
+import org.forester.io.parsers.tol.TolParser;\r
+import org.forester.io.parsers.util.ParserUtils;\r
+import org.forester.io.writers.PhylogenyWriter;\r
+import org.forester.io.writers.SequenceWriter;\r
+import org.forester.msa.Msa;\r
+import org.forester.msa.MsaFormatException;\r
+import org.forester.phylogeny.Phylogeny;\r
+import org.forester.phylogeny.PhylogenyMethods;\r
+import org.forester.phylogeny.PhylogenyNode;\r
+import org.forester.phylogeny.PhylogenyNode.NH_CONVERSION_SUPPORT_VALUE_STYLE;\r
+import org.forester.phylogeny.data.Confidence;\r
+import org.forester.phylogeny.data.Taxonomy;\r
+import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;\r
+import org.forester.phylogeny.factories.PhylogenyFactory;\r
+import org.forester.phylogeny.iterators.PhylogenyNodeIterator;\r
+import org.forester.sequence.Sequence;\r
+import org.forester.util.BasicDescriptiveStatistics;\r
+import org.forester.util.BasicTable;\r
+import org.forester.util.BasicTableParser;\r
+import org.forester.util.DescriptiveStatistics;\r
+import org.forester.util.ForesterUtil;\r
+import org.forester.util.WindowsUtils;\r
+\r
+public final class MainFrameApplication extends MainFrame {\r
+\r
+    static final String                      INFER_ANCESTOR_TAXONOMIES             = "Infer Ancestor Taxonomies";\r
+    static final String                      OBTAIN_DETAILED_TAXONOMIC_INFORMATION = "Obtain Detailed Taxonomic Information";\r
+    private final static int                 FRAME_X_SIZE                          = 800;\r
+    private final static int                 FRAME_Y_SIZE                          = 800;\r
+    // Filters for the file-open dialog (classes defined in this file)\r
+    private final static NHFilter            nhfilter                              = new NHFilter();\r
+    private final static NHXFilter           nhxfilter                             = new NHXFilter();\r
+    private final static XMLFilter           xmlfilter                             = new XMLFilter();\r
+    private final static TolFilter           tolfilter                             = new TolFilter();\r
+    private final static NexusFilter         nexusfilter                           = new NexusFilter();\r
+    private final static PdfFilter           pdffilter                             = new PdfFilter();\r
+    private final static GraphicsFileFilter  graphicsfilefilter                    = new GraphicsFileFilter();\r
+    private final static MsaFileFilter       msafilter                             = new MsaFileFilter();\r
+    private final static SequencesFileFilter seqsfilter                            = new SequencesFileFilter();\r
+    private final static DefaultFilter       defaultfilter                         = new DefaultFilter();\r
+    private static final long                serialVersionUID                      = -799735726778865234L;\r
+    private final JFileChooser               _values_filechooser;\r
+    private final JFileChooser               _sequences_filechooser;\r
+    private final JFileChooser               _open_filechooser;\r
+    private final JFileChooser               _msa_filechooser;\r
+    private final JFileChooser               _seqs_pi_filechooser;\r
+    private final JFileChooser               _open_filechooser_for_species_tree;\r
+    private final JFileChooser               _save_filechooser;\r
+    private final JFileChooser               _writetopdf_filechooser;\r
+    private final JFileChooser               _writetographics_filechooser;\r
+    // Application-only print menu items\r
+    private JMenuItem                        _print_item;\r
+    private JMenuItem                        _write_to_pdf_item;\r
+    private JMenuItem                        _write_to_jpg_item;\r
+    private JMenuItem                        _write_to_gif_item;\r
+    private JMenuItem                        _write_to_tif_item;\r
+    private JMenuItem                        _write_to_png_item;\r
+    private JMenuItem                        _write_to_bmp_item;\r
+    private File                             _current_dir;\r
+    private ButtonGroup                      _radio_group_1;\r
+    private ButtonGroup                      _radio_group_2;\r
+    // Others:\r
+    double                                   _min_not_collapse                     = Constants.MIN_NOT_COLLAPSE_DEFAULT;\r
+    // Phylogeny Inference menu\r
+    private JMenu                            _inference_menu;\r
+    private JMenuItem                        _inference_from_msa_item;\r
+    private JMenuItem                        _inference_from_seqs_item;\r
+    // Phylogeny Inference\r
+    private PhylogeneticInferenceOptions     _phylogenetic_inference_options       = null;\r
+    private Msa                              _msa                                  = null;\r
+    private File                             _msa_file                             = null;\r
+    private List<Sequence>                   _seqs                                 = null;\r
+    private File                             _seqs_file                            = null;\r
+    JMenuItem                                _read_values_jmi;\r
+    JMenuItem                                _read_seqs_jmi;\r
+\r
+    private MainFrameApplication( final Phylogeny[] phys, final Configuration config ) {\r
+        _configuration = config;\r
+        if ( _configuration == null ) {\r
+            throw new IllegalArgumentException( "configuration is null" );\r
+        }\r
+        setVisible( false );\r
+        setOptions( Options.createInstance( _configuration ) );\r
+        _mainpanel = new MainPanel( _configuration, this );\r
+        _open_filechooser = null;\r
+        _open_filechooser_for_species_tree = null;\r
+        _save_filechooser = null;\r
+        _writetopdf_filechooser = null;\r
+        _writetographics_filechooser = null;\r
+        _msa_filechooser = null;\r
+        _seqs_pi_filechooser = null;\r
+        _values_filechooser = null;\r
+        _sequences_filechooser = null;\r
+        _jmenubar = new JMenuBar();\r
+        buildFileMenu();\r
+        buildTypeMenu();\r
+        _contentpane = getContentPane();\r
+        _contentpane.setLayout( new BorderLayout() );\r
+        _contentpane.add( _mainpanel, BorderLayout.CENTER );\r
+        // App is this big\r
+        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );\r
+        // The window listener\r
+        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );\r
+        addWindowListener( new WindowAdapter() {\r
+\r
+            @Override\r
+            public void windowClosing( final WindowEvent e ) {\r
+                exit();\r
+            }\r
+        } );\r
+        //   setVisible( true );\r
+        if ( ( phys != null ) && ( phys.length > 0 ) ) {\r
+            AptxUtil.addPhylogeniesToTabs( phys, "", null, _configuration, _mainpanel );\r
+            validate();\r
+            getMainPanel().getControlPanel().showWholeAll();\r
+            getMainPanel().getControlPanel().showWhole();\r
+        }\r
+        //activateSaveAllIfNeeded();\r
+        // ...and its children\r
+        _contentpane.repaint();\r
+    }\r
+\r
+    private MainFrameApplication( final Phylogeny[] phys, final Configuration config, final String title ) {\r
+        this( phys, config, title, null );\r
+    }\r
+\r
+    private MainFrameApplication( final Phylogeny[] phys,\r
+                                  final Configuration config,\r
+                                  final String title,\r
+                                  final File current_dir ) {\r
+        super();\r
+        _configuration = config;\r
+        if ( _configuration == null ) {\r
+            throw new IllegalArgumentException( "configuration is null" );\r
+        }\r
+        try {\r
+            boolean synth_exception = false;\r
+            if ( Constants.__SYNTH_LF ) {\r
+                try {\r
+                    final SynthLookAndFeel synth = new SynthLookAndFeel();\r
+                    synth.load( MainFrameApplication.class.getResourceAsStream( "/resources/synth_look_and_feel_1.xml" ),\r
+                                MainFrameApplication.class );\r
+                    UIManager.setLookAndFeel( synth );\r
+                }\r
+                catch ( final Exception ex ) {\r
+                    synth_exception = true;\r
+                    ForesterUtil.printWarningMessage( Constants.PRG_NAME,\r
+                                                      "could not create synth look and feel: "\r
+                                                              + ex.getLocalizedMessage() );\r
+                }\r
+            }\r
+            if ( !Constants.__SYNTH_LF || synth_exception ) {\r
+                if ( _configuration.isUseNativeUI() ) {\r
+                    UIManager.setLookAndFeel( UIManager.getSystemLookAndFeelClassName() );\r
+                }\r
+                else {\r
+                    UIManager.setLookAndFeel( UIManager.getCrossPlatformLookAndFeelClassName() );\r
+                }\r
+            }\r
+            //UIManager.setLookAndFeel( "com.sun.java.swing.plaf.nimbus.NimbusLookAndFeel" );\r
+        }\r
+        catch ( final UnsupportedLookAndFeelException e ) {\r
+            AptxUtil.dieWithSystemError( "unsupported look and feel: " + e.toString() );\r
+        }\r
+        catch ( final ClassNotFoundException e ) {\r
+            AptxUtil.dieWithSystemError( "class not found exception: " + e.toString() );\r
+        }\r
+        catch ( final InstantiationException e ) {\r
+            AptxUtil.dieWithSystemError( "instantiation exception: " + e.toString() );\r
+        }\r
+        catch ( final IllegalAccessException e ) {\r
+            AptxUtil.dieWithSystemError( "illegal access exception: " + e.toString() );\r
+        }\r
+        if ( ( current_dir != null ) && current_dir.canRead() && current_dir.isDirectory() ) {\r
+            setCurrentDir( current_dir );\r
+        }\r
+        // hide until everything is ready\r
+        setVisible( false );\r
+        setOptions( Options.createInstance( _configuration ) );\r
+        setInferenceManager( InferenceManager.createInstance( _configuration ) );\r
+        setPhylogeneticInferenceOptions( PhylogeneticInferenceOptions.createInstance( _configuration ) );\r
+        //     _textframe = null; #~~~~\r
+        // set title\r
+        setTitle( Constants.PRG_NAME + " " + Constants.VERSION + " (" + Constants.PRG_DATE + ")" );\r
+        _mainpanel = new MainPanel( _configuration, this );\r
+        // The file dialogs\r
+        _open_filechooser = new JFileChooser();\r
+        _open_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _open_filechooser.setMultiSelectionEnabled( false );\r
+        _open_filechooser.addChoosableFileFilter( MainFrameApplication.xmlfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhxfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );\r
+        _open_filechooser.addChoosableFileFilter( MainFrameApplication.tolfilter );\r
+        _open_filechooser.addChoosableFileFilter( _open_filechooser.getAcceptAllFileFilter() );\r
+        _open_filechooser.setFileFilter( MainFrameApplication.defaultfilter );\r
+        _open_filechooser_for_species_tree = new JFileChooser();\r
+        _open_filechooser_for_species_tree.setCurrentDirectory( new File( "." ) );\r
+        _open_filechooser_for_species_tree.setMultiSelectionEnabled( false );\r
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.xmlfilter );\r
+        _open_filechooser_for_species_tree.addChoosableFileFilter( MainFrameApplication.tolfilter );\r
+        _open_filechooser_for_species_tree.setFileFilter( MainFrameApplication.xmlfilter );\r
+        _save_filechooser = new JFileChooser();\r
+        _save_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _save_filechooser.setMultiSelectionEnabled( false );\r
+        _save_filechooser.setFileFilter( MainFrameApplication.xmlfilter );\r
+        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nhfilter );\r
+        _save_filechooser.addChoosableFileFilter( MainFrameApplication.nexusfilter );\r
+        _save_filechooser.addChoosableFileFilter( _save_filechooser.getAcceptAllFileFilter() );\r
+        _writetopdf_filechooser = new JFileChooser();\r
+        _writetopdf_filechooser.addChoosableFileFilter( MainFrameApplication.pdffilter );\r
+        _writetographics_filechooser = new JFileChooser();\r
+        _writetographics_filechooser.addChoosableFileFilter( MainFrameApplication.graphicsfilefilter );\r
+        // Msa:\r
+        _msa_filechooser = new JFileChooser();\r
+        _msa_filechooser.setName( "Read Multiple Sequence Alignment File" );\r
+        _msa_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _msa_filechooser.setMultiSelectionEnabled( false );\r
+        _msa_filechooser.addChoosableFileFilter( _msa_filechooser.getAcceptAllFileFilter() );\r
+        _msa_filechooser.addChoosableFileFilter( MainFrameApplication.msafilter );\r
+        // Seqs:\r
+        _seqs_pi_filechooser = new JFileChooser();\r
+        _seqs_pi_filechooser.setName( "Read Sequences File" );\r
+        _seqs_pi_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
+        _seqs_pi_filechooser.addChoosableFileFilter( _seqs_pi_filechooser.getAcceptAllFileFilter() );\r
+        _seqs_pi_filechooser.addChoosableFileFilter( MainFrameApplication.seqsfilter );\r
+        // Expression\r
+        _values_filechooser = new JFileChooser();\r
+        _values_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _values_filechooser.setMultiSelectionEnabled( false );\r
+        // Sequences\r
+        _sequences_filechooser = new JFileChooser();\r
+        _sequences_filechooser.setCurrentDirectory( new File( "." ) );\r
+        _sequences_filechooser.setMultiSelectionEnabled( false );\r
+        // build the menu bar\r
+        _jmenubar = new JMenuBar();\r
+        if ( !_configuration.isUseNativeUI() ) {\r
+            _jmenubar.setBackground( getConfiguration().getGuiMenuBackgroundColor() );\r
+        }\r
+        buildFileMenu();\r
+        if ( Constants.__ALLOW_PHYLOGENETIC_INFERENCE ) {\r
+            buildPhylogeneticInferenceMenu();\r
+        }\r
+        buildAnalysisMenu();\r
+        buildToolsMenu();\r
+        buildViewMenu();\r
+        buildFontSizeMenu();\r
+        buildOptionsMenu();\r
+        buildTypeMenu();\r
+        buildHelpMenu();\r
+        setJMenuBar( _jmenubar );\r
+        _jmenubar.add( _help_jmenu );\r
+        _contentpane = getContentPane();\r
+        _contentpane.setLayout( new BorderLayout() );\r
+        _contentpane.add( _mainpanel, BorderLayout.CENTER );\r
+        // App is this big\r
+        setSize( MainFrameApplication.FRAME_X_SIZE, MainFrameApplication.FRAME_Y_SIZE );\r
+        //        addWindowFocusListener( new WindowAdapter() {\r
+        //\r
+        //            @Override\r
+        //            public void windowGainedFocus( WindowEvent e ) {\r
+        //                requestFocusInWindow();\r
+        //            }\r
+        //        } );\r
+        // The window listener\r
+        setDefaultCloseOperation( WindowConstants.DO_NOTHING_ON_CLOSE );\r
+        addWindowListener( new WindowAdapter() {\r
+\r
+            @Override\r
+            public void windowClosing( final WindowEvent e ) {\r
+                if ( isUnsavedDataPresent() ) {\r
+                    final int r = JOptionPane.showConfirmDialog( null,\r
+                                                                 "Exit despite potentially unsaved changes?",\r
+                                                                 "Exit?",\r
+                                                                 JOptionPane.YES_NO_OPTION );\r
+                    if ( r != JOptionPane.YES_OPTION ) {\r
+                        return;\r
+                    }\r
+                }\r
+                else {\r
+                    final int r = JOptionPane.showConfirmDialog( null,\r
+                                                                 "Exit Archaeopteryx?",\r
+                                                                 "Exit?",\r
+                                                                 JOptionPane.YES_NO_OPTION );\r
+                    if ( r != JOptionPane.YES_OPTION ) {\r
+                        return;\r
+                    }\r
+                }\r
+                exit();\r
+            }\r
+        } );\r
+        // The component listener\r
+        addComponentListener( new ComponentAdapter() {\r
+\r
+            @Override\r
+            public void componentResized( final ComponentEvent e ) {\r
+                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                    _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel()\r
+                                                                                        .getWidth(),\r
+                                                                                _mainpanel.getCurrentTreePanel()\r
+                                                                                        .getHeight(),\r
+                                                                                getOptions().isAllowFontSizeChange() );\r
+                }\r
+            }\r
+        } );\r
+        requestFocusInWindow();\r
+        // addKeyListener( this );\r
+        setVisible( true );\r
+        if ( ( phys != null ) && ( phys.length > 0 ) ) {\r
+            AptxUtil.addPhylogeniesToTabs( phys, title, null, _configuration, _mainpanel );\r
+            validate();\r
+            getMainPanel().getControlPanel().showWholeAll();\r
+            getMainPanel().getControlPanel().showWhole();\r
+        }\r
+        activateSaveAllIfNeeded();\r
+        // ...and its children\r
+        _contentpane.repaint();\r
+        System.gc();\r
+    }\r
+\r
+    private MainFrameApplication( final Phylogeny[] phys, final String config_file, final String title ) {\r
+        // Reads the config file (false, false => not url, not applet):\r
+        this( phys, new Configuration( config_file, false, false, true ), title );\r
+    }\r
+\r
+    @Override\r
+    public void actionPerformed( final ActionEvent e ) {\r
+        try {\r
+            super.actionPerformed( e );\r
+            final Object o = e.getSource();\r
+            // Handle app-specific actions here:\r
+            if ( o == _open_item ) {\r
+                readPhylogeniesFromFile();\r
+            }\r
+            if ( o == _open_url_item ) {\r
+                readPhylogeniesFromURL();\r
+            }\r
+            else if ( o == _save_item ) {\r
+                writeToFile( _mainpanel.getCurrentPhylogeny() );\r
+                // If subtree currently displayed, save it, instead of complete\r
+                // tree.\r
+            }\r
+            else if ( o == _new_item ) {\r
+                newTree();\r
+            }\r
+            else if ( o == _save_all_item ) {\r
+                writeAllToFile();\r
+            }\r
+            else if ( o == _close_item ) {\r
+                closeCurrentPane();\r
+            }\r
+            else if ( o == _write_to_pdf_item ) {\r
+                writeToPdf( _mainpanel.getCurrentPhylogeny() );\r
+            }\r
+            else if ( o == _write_to_jpg_item ) {\r
+                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.JPG );\r
+            }\r
+            else if ( o == _write_to_png_item ) {\r
+                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.PNG );\r
+            }\r
+            else if ( o == _write_to_gif_item ) {\r
+                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.GIF );\r
+            }\r
+            else if ( o == _write_to_tif_item ) {\r
+                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.TIFF );\r
+            }\r
+            else if ( o == _write_to_bmp_item ) {\r
+                writeToGraphicsFile( _mainpanel.getCurrentPhylogeny(), GraphicsExportType.BMP );\r
+            }\r
+            else if ( o == _print_item ) {\r
+                print();\r
+            }\r
+            else if ( o == _load_species_tree_item ) {\r
+                readSpeciesTreeFromFile();\r
+            }\r
+            else if ( o == _lineage_inference ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Subtree is shown.",\r
+                                                   "Cannot infer ancestral taxonomies",\r
+                                                   JOptionPane.ERROR_MESSAGE );\r
+                    return;\r
+                }\r
+                executeLineageInference();\r
+            }\r
+            else if ( o == _obtain_detailed_taxonomic_information_jmi ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                obtainDetailedTaxonomicInformation();\r
+            }\r
+            else if ( o == _obtain_detailed_taxonomic_information_deleting_jmi ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                obtainDetailedTaxonomicInformationDelete();\r
+            }\r
+            else if ( o == _obtain_seq_information_jmi ) {\r
+                obtainSequenceInformation();\r
+            }\r
+            else if ( o == _read_values_jmi ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                addExpressionValuesFromFile();\r
+            }\r
+            else if ( o == _read_seqs_jmi ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                addSequencesFromFile();\r
+            }\r
+            else if ( o == _move_node_names_to_tax_sn_jmi ) {\r
+                moveNodeNamesToTaxSn();\r
+            }\r
+            else if ( o == _move_node_names_to_seq_names_jmi ) {\r
+                moveNodeNamesToSeqNames();\r
+            }\r
+            else if ( o == _extract_tax_code_from_node_names_jmi ) {\r
+                extractTaxDataFromNodeNames();\r
+            }\r
+            else if ( o == _graphics_export_visible_only_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _antialias_print_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _print_black_and_white_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _print_using_actual_size_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _graphics_export_using_actual_size_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _print_size_mi ) {\r
+                choosePrintSize();\r
+            }\r
+            else if ( o == _choose_pdf_width_mi ) {\r
+                choosePdfWidth();\r
+            }\r
+            else if ( o == _internal_number_are_confidence_for_nh_parsing_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _replace_underscores_cbmi ) {\r
+                if ( ( _extract_taxonomy_no_rbmi != null ) && !_extract_taxonomy_no_rbmi.isSelected() ) {\r
+                    _extract_taxonomy_no_rbmi.setSelected( true );\r
+                }\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _allow_errors_in_distance_to_parent_cbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _collapse_below_threshold ) {\r
+                if ( isSubtreeDisplayed() ) {\r
+                    return;\r
+                }\r
+                collapseBelowThreshold();\r
+            }\r
+            else if ( ( o == _extract_taxonomy_pfam_strict_rbmi ) || ( o == _extract_taxonomy_pfam_relaxed_rbmi )\r
+                    || ( o == _extract_taxonomy_agressive_rbmi ) ) {\r
+                if ( _replace_underscores_cbmi != null ) {\r
+                    _replace_underscores_cbmi.setSelected( false );\r
+                }\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _extract_taxonomy_no_rbmi ) {\r
+                updateOptions( getOptions() );\r
+            }\r
+            else if ( o == _inference_from_msa_item ) {\r
+                executePhyleneticInference( false );\r
+            }\r
+            else if ( o == _inference_from_seqs_item ) {\r
+                executePhyleneticInference( true );\r
+            }\r
+            _contentpane.repaint();\r
+        }\r
+        catch ( final Exception ex ) {\r
+            AptxUtil.unexpectedException( ex );\r
+        }\r
+        catch ( final Error err ) {\r
+            AptxUtil.unexpectedError( err );\r
+        }\r
+    }\r
+\r
+    public void end() {\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+    }\r
+\r
+    @Override\r
+    public MainPanel getMainPanel() {\r
+        return _mainpanel;\r
+    }\r
+\r
+    public Msa getMsa() {\r
+        return _msa;\r
+    }\r
+\r
+    public File getMsaFile() {\r
+        return _msa_file;\r
+    }\r
+\r
+    public List<Sequence> getSeqs() {\r
+        return _seqs;\r
+    }\r
+\r
+    public File getSeqsFile() {\r
+        return _seqs_file;\r
+    }\r
+\r
+    public void readMsaFromFile() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _msa_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _msa_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _msa_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the msa\r
+        final File file = _msa_filechooser.getSelectedFile();\r
+        setCurrentDir( _msa_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setMsaFile( null );\r
+            setMsa( null );\r
+            Msa msa = null;\r
+            try {\r
+                final InputStream is = new FileInputStream( file );\r
+                if ( FastaParser.isLikelyFasta( file ) ) {\r
+                    msa = FastaParser.parseMsa( is );\r
+                }\r
+                else {\r
+                    msa = GeneralMsaParser.parse( is );\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence alignment format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( msa == null ) || ( msa.getNumberOfSequences() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment is empty",\r
+                                               "Illegal Multiple Sequence Alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getNumberOfSequences() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( msa.getLength() < 2 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence alignment needs to contain at least 2 residues",\r
+                                               "Illegal multiple sequence alignment",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            System.gc();\r
+            setMsaFile( _msa_filechooser.getSelectedFile() );\r
+            setMsa( msa );\r
+        }\r
+    }\r
+\r
+    public void readSeqsFromFileforPI() {\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _seqs_pi_filechooser.setMultiSelectionEnabled( false );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _seqs_pi_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _seqs_pi_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the seqs\r
+        final File file = _seqs_pi_filechooser.getSelectedFile();\r
+        setCurrentDir( _seqs_pi_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            setSeqsFile( null );\r
+            setSeqs( null );\r
+            List<Sequence> seqs = null;\r
+            try {\r
+                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
+                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
+                    for( final Sequence seq : seqs ) {\r
+                        System.out.println( SequenceWriter.toFasta( seq, 60 ) );\r
+                    }\r
+                }\r
+                else {\r
+                    //TODO error\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence file format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IllegalArgumentException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file is empty",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( seqs.size() < 4 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file needs to contain at least 3 sequences",\r
+                                               "Illegal multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            //  if ( msa.getLength() < 2 ) {\r
+            //       JOptionPane.showMessageDialog( this,\r
+            //                                      "Multiple sequence alignment needs to contain at least 2 residues",\r
+            //                                      "Illegal multiple sequence file",\r
+            //                                      JOptionPane.ERROR_MESSAGE );\r
+            //       return;\r
+            //   }\r
+            System.gc();\r
+            setSeqsFile( _seqs_pi_filechooser.getSelectedFile() );\r
+            setSeqs( seqs );\r
+        }\r
+    }\r
+\r
+    void buildAnalysisMenu() {\r
+        _analysis_menu = MainFrame.createMenu( "Analysis", getConfiguration() );\r
+        _analysis_menu.add( _gsdi_item = new JMenuItem( "GSDI (Generalized Speciation Duplication Inference)" ) );\r
+        _analysis_menu.add( _gsdir_item = new JMenuItem( "GSDIR (GSDI with re-rooting)" ) );\r
+        _analysis_menu.add( _load_species_tree_item = new JMenuItem( "Load Species Tree..." ) );\r
+        customizeJMenuItem( _gsdi_item );\r
+        customizeJMenuItem( _gsdir_item );\r
+        customizeJMenuItem( _load_species_tree_item );\r
+        _analysis_menu.addSeparator();\r
+        _analysis_menu.add( _lineage_inference = new JMenuItem( INFER_ANCESTOR_TAXONOMIES ) );\r
+        customizeJMenuItem( _lineage_inference );\r
+        _lineage_inference.setToolTipText( "Inference of ancestor taxonomies/lineages" );\r
+        _jmenubar.add( _analysis_menu );\r
+    }\r
+\r
+    @Override\r
+    void buildFileMenu() {\r
+        _file_jmenu = MainFrame.createMenu( "File", getConfiguration() );\r
+        _file_jmenu.add( _open_item = new JMenuItem( "Read Tree from File..." ) );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _open_url_item = new JMenuItem( "Read Tree from URL/Webservice..." ) );\r
+        _file_jmenu.addSeparator();\r
+        final WebservicesManager webservices_manager = WebservicesManager.getInstance();\r
+        _load_phylogeny_from_webservice_menu_items = new JMenuItem[ webservices_manager\r
+                .getAvailablePhylogeniesWebserviceClients().size() ];\r
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
+            final PhylogeniesWebserviceClient client = webservices_manager.getAvailablePhylogeniesWebserviceClient( i );\r
+            _load_phylogeny_from_webservice_menu_items[ i ] = new JMenuItem( client.getMenuName() );\r
+            _file_jmenu.add( _load_phylogeny_from_webservice_menu_items[ i ] );\r
+        }\r
+        if ( getConfiguration().isEditable() ) {\r
+            _file_jmenu.addSeparator();\r
+            _file_jmenu.add( _new_item = new JMenuItem( "New" ) );\r
+            _new_item.setToolTipText( "to create a new tree with one node, as source for manual tree construction" );\r
+        }\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _save_item = new JMenuItem( "Save Tree As..." ) );\r
+        _file_jmenu.add( _save_all_item = new JMenuItem( "Save All Trees As..." ) );\r
+        _save_all_item.setToolTipText( "Write all phylogenies to one file." );\r
+        _save_all_item.setEnabled( false );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _write_to_pdf_item = new JMenuItem( "Export to PDF file ..." ) );\r
+        if ( AptxUtil.canWriteFormat( "tif" ) || AptxUtil.canWriteFormat( "tiff" ) || AptxUtil.canWriteFormat( "TIF" ) ) {\r
+            _file_jmenu.add( _write_to_tif_item = new JMenuItem( "Export to TIFF file..." ) );\r
+        }\r
+        _file_jmenu.add( _write_to_png_item = new JMenuItem( "Export to PNG file..." ) );\r
+        _file_jmenu.add( _write_to_jpg_item = new JMenuItem( "Export to JPG file..." ) );\r
+        if ( AptxUtil.canWriteFormat( "gif" ) ) {\r
+            _file_jmenu.add( _write_to_gif_item = new JMenuItem( "Export to GIF file..." ) );\r
+        }\r
+        if ( AptxUtil.canWriteFormat( "bmp" ) ) {\r
+            _file_jmenu.add( _write_to_bmp_item = new JMenuItem( "Export to BMP file..." ) );\r
+        }\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _print_item = new JMenuItem( "Print..." ) );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _close_item = new JMenuItem( "Close Tab" ) );\r
+        _close_item.setToolTipText( "To close the current pane." );\r
+        _close_item.setEnabled( true );\r
+        _file_jmenu.addSeparator();\r
+        _file_jmenu.add( _exit_item = new JMenuItem( "Exit" ) );\r
+        customizeJMenuItem( _open_item );\r
+        _open_item\r
+                .setFont( new Font( _open_item.getFont().getFontName(), Font.BOLD, _open_item.getFont().getSize() + 4 ) );\r
+        customizeJMenuItem( _open_url_item );\r
+        for( int i = 0; i < webservices_manager.getAvailablePhylogeniesWebserviceClients().size(); ++i ) {\r
+            customizeJMenuItem( _load_phylogeny_from_webservice_menu_items[ i ] );\r
+        }\r
+        customizeJMenuItem( _save_item );\r
+        if ( getConfiguration().isEditable() ) {\r
+            customizeJMenuItem( _new_item );\r
+        }\r
+        customizeJMenuItem( _close_item );\r
+        customizeJMenuItem( _save_all_item );\r
+        customizeJMenuItem( _write_to_pdf_item );\r
+        customizeJMenuItem( _write_to_png_item );\r
+        customizeJMenuItem( _write_to_jpg_item );\r
+        customizeJMenuItem( _write_to_gif_item );\r
+        customizeJMenuItem( _write_to_tif_item );\r
+        customizeJMenuItem( _write_to_bmp_item );\r
+        customizeJMenuItem( _print_item );\r
+        customizeJMenuItem( _exit_item );\r
+        _jmenubar.add( _file_jmenu );\r
+    }\r
+\r
+    void buildOptionsMenu() {\r
+        _options_jmenu = MainFrame.createMenu( OPTIONS_HEADER, getConfiguration() );\r
+        _options_jmenu.addChangeListener( new ChangeListener() {\r
+\r
+            @Override\r
+            public void stateChanged( final ChangeEvent e ) {\r
+                MainFrame.setOvPlacementColorChooseMenuItem( _overview_placment_mi, getOptions() );\r
+                MainFrame.setTextColorChooseMenuItem( _switch_colors_mi, getCurrentTreePanel() );\r
+                MainFrame\r
+                        .setTextMinSupportMenuItem( _choose_minimal_confidence_mi, getOptions(), getCurrentTreePanel() );\r
+                MainFrame.setTextForFontChooserMenuItem( _choose_font_mi, MainFrame\r
+                        .createCurrentFontDesc( getMainPanel().getTreeFontSet() ) );\r
+                setTextForGraphicsSizeChooserMenuItem( _print_size_mi, getOptions() );\r
+                setTextForPdfLineWidthChooserMenuItem( _choose_pdf_width_mi, getOptions() );\r
+                MainFrame.updateOptionsMenuDependingOnPhylogenyType( getMainPanel(),\r
+                                                                     _show_scale_cbmi,\r
+                                                                     _show_branch_length_values_cbmi,\r
+                                                                     _non_lined_up_cladograms_rbmi,\r
+                                                                     _uniform_cladograms_rbmi,\r
+                                                                     _ext_node_dependent_cladogram_rbmi,\r
+                                                                     _label_direction_cbmi );\r
+                MainFrame.setCycleNodeFillMenuItem( _cycle_node_fill_mi, getOptions() );\r
+                MainFrame.setCycleNodeShapeMenuItem( _cycle_node_shape_mi, getOptions() );\r
+                MainFrame.setTextNodeSizeMenuItem( _choose_node_size_mi, getOptions() );\r
+            }\r
+        } );\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( DISPLAY_SUBHEADER ), getConfiguration() ) );\r
+        _options_jmenu\r
+                .add( _ext_node_dependent_cladogram_rbmi = new JRadioButtonMenuItem( MainFrame.NONUNIFORM_CLADOGRAMS_LABEL ) );\r
+        _options_jmenu.add( _uniform_cladograms_rbmi = new JRadioButtonMenuItem( MainFrame.UNIFORM_CLADOGRAMS_LABEL ) );\r
+        _options_jmenu.add( _non_lined_up_cladograms_rbmi = new JRadioButtonMenuItem( NON_LINED_UP_CLADOGRAMS_LABEL ) );\r
+        _radio_group_1 = new ButtonGroup();\r
+        _radio_group_1.add( _ext_node_dependent_cladogram_rbmi );\r
+        _radio_group_1.add( _uniform_cladograms_rbmi );\r
+        _radio_group_1.add( _non_lined_up_cladograms_rbmi );\r
+        ///////\r
+        _options_jmenu.add( _show_overview_cbmi = new JCheckBoxMenuItem( SHOW_OVERVIEW_LABEL ) );\r
+        _options_jmenu.add( _show_scale_cbmi = new JCheckBoxMenuItem( DISPLAY_SCALE_LABEL ) );\r
+        _options_jmenu\r
+                .add( _show_branch_length_values_cbmi = new JCheckBoxMenuItem( DISPLAY_BRANCH_LENGTH_VALUES_LABEL ) );\r
+        _options_jmenu\r
+                .add( _show_default_node_shapes_internal_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_INT ) );\r
+        _options_jmenu\r
+                .add( _show_default_node_shapes_external_cbmi = new JCheckBoxMenuItem( DISPLAY_NODE_BOXES_LABEL_EXT ) );\r
+        if ( getConfiguration().doDisplayOption( Configuration.show_domain_architectures ) ) {\r
+            _options_jmenu.add( _show_domain_labels = new JCheckBoxMenuItem( SHOW_DOMAIN_LABELS_LABEL ) );\r
+        }\r
+        _options_jmenu.add( _show_annotation_ref_source = new JCheckBoxMenuItem( SHOW_ANN_REF_SOURCE_LABEL ) );\r
+        _options_jmenu.add( _show_confidence_stddev_cbmi = new JCheckBoxMenuItem( SHOW_CONF_STDDEV_LABEL ) );\r
+        _options_jmenu.add( _color_by_taxonomic_group_cbmi = new JCheckBoxMenuItem( COLOR_BY_TAXONOMIC_GROUP ) );\r
+        _options_jmenu.add( _color_labels_same_as_parent_branch = new JCheckBoxMenuItem( COLOR_LABELS_LABEL ) );\r
+        _color_labels_same_as_parent_branch.setToolTipText( MainFrame.COLOR_LABELS_TIP );\r
+        _options_jmenu.add( _abbreviate_scientific_names = new JCheckBoxMenuItem( ABBREV_SN_LABEL ) );\r
+        _options_jmenu.add( _label_direction_cbmi = new JCheckBoxMenuItem( LABEL_DIRECTION_LABEL ) );\r
+        _label_direction_cbmi.setToolTipText( LABEL_DIRECTION_TIP );\r
+        _options_jmenu.add( _screen_antialias_cbmi = new JCheckBoxMenuItem( SCREEN_ANTIALIAS_LABEL ) );\r
+        _options_jmenu.add( _background_gradient_cbmi = new JCheckBoxMenuItem( BG_GRAD_LABEL ) );\r
+        _options_jmenu.add( _cycle_node_shape_mi = new JMenuItem( MainFrame.CYCLE_NODE_SHAPE_LABEL ) );\r
+        _options_jmenu.add( _cycle_node_fill_mi = new JMenuItem( MainFrame.CYCLE_NODE_FILL_LABEL ) );\r
+        _options_jmenu.add( _choose_node_size_mi = new JMenuItem( MainFrame.CHOOSE_NODE_SIZE_LABEL ) );\r
+        _options_jmenu.add( _choose_minimal_confidence_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _overview_placment_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _switch_colors_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _choose_font_mi = new JMenuItem( "" ) );\r
+        ///////\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( SEARCH_SUBHEADER ), getConfiguration() ) );\r
+        _options_jmenu.add( _search_case_senstive_cbmi = new JCheckBoxMenuItem( SEARCH_CASE_SENSITIVE_LABEL ) );\r
+        _options_jmenu.add( _search_whole_words_only_cbmi = new JCheckBoxMenuItem( SEARCH_TERMS_ONLY_LABEL ) );\r
+        _options_jmenu.add( _inverse_search_result_cbmi = new JCheckBoxMenuItem( INVERSE_SEARCH_RESULT_LABEL ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Graphics Export & Printing:" ),\r
+                                                      getConfiguration() ) );\r
+        _options_jmenu.add( _antialias_print_cbmi = new JCheckBoxMenuItem( "Antialias" ) );\r
+        _options_jmenu.add( _print_black_and_white_cbmi = new JCheckBoxMenuItem( "Export in Black and White" ) );\r
+        _options_jmenu\r
+                .add( _print_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PDF export and Printing" ) );\r
+        _options_jmenu\r
+                .add( _graphics_export_using_actual_size_cbmi = new JCheckBoxMenuItem( "Use Current Image Size for PNG, JPG, and GIF export" ) );\r
+        _options_jmenu\r
+                .add( _graphics_export_visible_only_cbmi = new JCheckBoxMenuItem( "Limit to Visible ('Screenshot') for PNG, JPG, and GIF export" ) );\r
+        _options_jmenu.add( _print_size_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.add( _choose_pdf_width_mi = new JMenuItem( "" ) );\r
+        _options_jmenu.addSeparator();\r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/NHX/Nexus Input:" ), getConfiguration() ) );\r
+        _options_jmenu\r
+                .add( _internal_number_are_confidence_for_nh_parsing_cbmi = new JCheckBoxMenuItem( "Internal Node Names are Confidence Values" ) );\r
+        _options_jmenu.add( _replace_underscores_cbmi = new JCheckBoxMenuItem( "Replace Underscores with Spaces" ) );\r
+        _options_jmenu\r
+                .add( _allow_errors_in_distance_to_parent_cbmi = new JCheckBoxMenuItem( "Ignore Distance Values Format Errors" ) );\r
+        //\r
+        _options_jmenu.add( _extract_taxonomy_no_rbmi = new JRadioButtonMenuItem( "No Taxonomy Extraction" ) );\r
+        _options_jmenu\r
+                .add( _extract_taxonomy_pfam_strict_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style Node Names" ) );\r
+        _options_jmenu\r
+                .add( _extract_taxonomy_pfam_relaxed_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids from Pfam-style like Node Names" ) );\r
+        _options_jmenu\r
+                .add( _extract_taxonomy_agressive_rbmi = new JRadioButtonMenuItem( "Extract Taxonomy Codes/Ids/Scientific Names from Node Names" ) );\r
+        _extract_taxonomy_pfam_strict_rbmi\r
+                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"BCL2_MOUSE/123-304\" or \"BCL2_10090/123-304\"" );\r
+        _extract_taxonomy_pfam_relaxed_rbmi\r
+                .setToolTipText( "To extract taxonomy codes/ids from node names in the form of e.g. \"bax_MOUSE\" or \"bax_10090\"" );\r
+        _extract_taxonomy_agressive_rbmi\r
+                .setToolTipText( "To extract taxonomy codes/ids or scientific names from node names in the form of e.g. \"MOUSE\" or \"10090\" or \"xyz_Nematostella_vectensis\"" );\r
+        _radio_group_2 = new ButtonGroup();\r
+        _radio_group_2.add( _extract_taxonomy_no_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_pfam_strict_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_pfam_relaxed_rbmi );\r
+        _radio_group_2.add( _extract_taxonomy_agressive_rbmi );\r
+        // \r
+        _options_jmenu.add( customizeMenuItemAsLabel( new JMenuItem( "Newick/Nexus Output:" ), getConfiguration() ) );\r
+        _options_jmenu\r
+                .add( _use_brackets_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_BRACKETS_FOR_CONF_IN_NH_LABEL ) );\r
+        _use_brackets_for_conf_in_nh_export_cbmi\r
+                .setToolTipText( "e.g. \"0.1[90]\" for a branch with support 90 and a length of 0.1" );\r
+        _options_jmenu\r
+                .add( _use_internal_names_for_conf_in_nh_export_cbmi = new JCheckBoxMenuItem( USE_INTERNAL_NAMES_FOR_CONF_IN_NH_LABEL ) );\r
+        customizeJMenuItem( _choose_font_mi );\r
+        customizeJMenuItem( _choose_minimal_confidence_mi );\r
+        customizeJMenuItem( _switch_colors_mi );\r
+        customizeJMenuItem( _print_size_mi );\r
+        customizeJMenuItem( _choose_pdf_width_mi );\r
+        customizeJMenuItem( _overview_placment_mi );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_external_cbmi, getOptions()\r
+                .isShowDefaultNodeShapesExternal() );\r
+        customizeCheckBoxMenuItem( _show_default_node_shapes_internal_cbmi, getOptions()\r
+                .isShowDefaultNodeShapesInternal() );\r
+        customizeJMenuItem( _cycle_node_shape_mi );\r
+        customizeJMenuItem( _cycle_node_fill_mi );\r
+        customizeJMenuItem( _choose_node_size_mi );\r
+        customizeCheckBoxMenuItem( _color_labels_same_as_parent_branch, getOptions().isColorLabelsSameAsParentBranch() );\r
+        customizeCheckBoxMenuItem( _color_by_taxonomic_group_cbmi, getOptions().isColorByTaxonomicGroup() );\r
+        customizeCheckBoxMenuItem( _screen_antialias_cbmi, getOptions().isAntialiasScreen() );\r
+        customizeCheckBoxMenuItem( _background_gradient_cbmi, getOptions().isBackgroundColorGradient() );\r
+        customizeCheckBoxMenuItem( _show_domain_labels, getOptions().isShowDomainLabels() );\r
+        customizeCheckBoxMenuItem( _show_annotation_ref_source, getOptions().isShowAnnotationRefSource() );\r
+        customizeCheckBoxMenuItem( _abbreviate_scientific_names, getOptions().isAbbreviateScientificTaxonNames() );\r
+        customizeCheckBoxMenuItem( _search_case_senstive_cbmi, getOptions().isSearchCaseSensitive() );\r
+        customizeCheckBoxMenuItem( _show_scale_cbmi, getOptions().isShowScale() );\r
+        customizeRadioButtonMenuItem( _non_lined_up_cladograms_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.NON_LINED_UP );\r
+        customizeRadioButtonMenuItem( _uniform_cladograms_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.TOTAL_NODE_SUM_DEP );\r
+        customizeRadioButtonMenuItem( _ext_node_dependent_cladogram_rbmi,\r
+                                      getOptions().getCladogramType() == CLADOGRAM_TYPE.EXT_NODE_SUM_DEP );\r
+        customizeCheckBoxMenuItem( _show_branch_length_values_cbmi, getOptions().isShowBranchLengthValues() );\r
+        customizeCheckBoxMenuItem( _show_overview_cbmi, getOptions().isShowOverview() );\r
+        customizeCheckBoxMenuItem( _label_direction_cbmi,\r
+                                   getOptions().getNodeLabelDirection() == NODE_LABEL_DIRECTION.RADIAL );\r
+        customizeCheckBoxMenuItem( _antialias_print_cbmi, getOptions().isAntialiasPrint() );\r
+        customizeCheckBoxMenuItem( _print_black_and_white_cbmi, getOptions().isPrintBlackAndWhite() );\r
+        customizeCheckBoxMenuItem( _internal_number_are_confidence_for_nh_parsing_cbmi, getOptions()\r
+                .isInternalNumberAreConfidenceForNhParsing() );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_no_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.NO );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_strict_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_STRICT );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_pfam_relaxed_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.PFAM_STYLE_RELAXED );\r
+        customizeRadioButtonMenuItem( _extract_taxonomy_agressive_rbmi,\r
+                                      getOptions().getTaxonomyExtraction() == TAXONOMY_EXTRACTION.AGGRESSIVE );\r
+        customizeCheckBoxMenuItem( _replace_underscores_cbmi, getOptions().isReplaceUnderscoresInNhParsing() );\r
+        customizeCheckBoxMenuItem( _allow_errors_in_distance_to_parent_cbmi, getOptions()\r
+                .isReplaceUnderscoresInNhParsing() );\r
+        customizeCheckBoxMenuItem( _search_whole_words_only_cbmi, getOptions().isMatchWholeTermsOnly() );\r
+        customizeCheckBoxMenuItem( _inverse_search_result_cbmi, getOptions().isInverseSearchResult() );\r
+        customizeCheckBoxMenuItem( _graphics_export_visible_only_cbmi, getOptions().isGraphicsExportVisibleOnly() );\r
+        customizeCheckBoxMenuItem( _print_using_actual_size_cbmi, getOptions().isPrintUsingActualSize() );\r
+        customizeCheckBoxMenuItem( _graphics_export_using_actual_size_cbmi, getOptions()\r
+                .isGraphicsExportUsingActualSize() );\r
+        customizeCheckBoxMenuItem( _show_confidence_stddev_cbmi, getOptions().isShowConfidenceStddev() );\r
+        customizeCheckBoxMenuItem( _use_brackets_for_conf_in_nh_export_cbmi, getOptions()\r
+                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.IN_SQUARE_BRACKETS );\r
+        customizeCheckBoxMenuItem( _use_internal_names_for_conf_in_nh_export_cbmi, getOptions()\r
+                .getNhConversionSupportValueStyle() == NH_CONVERSION_SUPPORT_VALUE_STYLE.AS_INTERNAL_NODE_NAMES );\r
+        _jmenubar.add( _options_jmenu );\r
+    }\r
+\r
+    void buildPhylogeneticInferenceMenu() {\r
+        final InferenceManager im = getInferenceManager();\r
+        _inference_menu = MainFrame.createMenu( "Inference", getConfiguration() );\r
+        _inference_menu.add( _inference_from_msa_item = new JMenuItem( "From Multiple Sequence Alignment..." ) );\r
+        customizeJMenuItem( _inference_from_msa_item );\r
+        _inference_from_msa_item.setToolTipText( "Basic phylogenetic inference from MSA" );\r
+        if ( im.canDoMsa() ) {\r
+            _inference_menu.add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences..." ) );\r
+            customizeJMenuItem( _inference_from_seqs_item );\r
+            _inference_from_seqs_item\r
+                    .setToolTipText( "Basic phylogenetic inference including multiple sequence alignment" );\r
+        }\r
+        else {\r
+            _inference_menu\r
+                    .add( _inference_from_seqs_item = new JMenuItem( "From Unaligned Sequences (no program found)" ) );\r
+            customizeJMenuItem( _inference_from_seqs_item );\r
+            _inference_from_seqs_item.setEnabled( false );\r
+        }\r
+        _jmenubar.add( _inference_menu );\r
+    }\r
+\r
+    void buildToolsMenu() {\r
+        _tools_menu = createMenu( "Tools", getConfiguration() );\r
+        _tools_menu.add( _confcolor_item = new JMenuItem( "Colorize Branches Depending on Confidence" ) );\r
+        customizeJMenuItem( _confcolor_item );\r
+        _tools_menu.add( _color_rank_jmi = new JMenuItem( "Colorize Subtrees via Taxonomic Rank" ) );\r
+        customizeJMenuItem( _color_rank_jmi );\r
+        _color_rank_jmi.setToolTipText( "for example, at \"Class\" level, colorize mammal specific subtree red" );\r
+        _tools_menu.add( _taxcolor_item = new JMenuItem( "Taxonomy Colorize Branches" ) );\r
+        customizeJMenuItem( _taxcolor_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _remove_visual_styles_item = new JMenuItem( "Delete All Visual Styles From Nodes" ) );\r
+        _remove_visual_styles_item\r
+                .setToolTipText( "To remove all node visual styles (fonts, colors) from the current phylogeny." );\r
+        customizeJMenuItem( _remove_visual_styles_item );\r
+        _tools_menu.add( _remove_branch_color_item = new JMenuItem( "Delete All Colors From Branches" ) );\r
+        _remove_branch_color_item.setToolTipText( "To remove all branch color values from the current phylogeny." );\r
+        customizeJMenuItem( _remove_branch_color_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _annotate_item = new JMenuItem( "Annotate Sequences of Selected Nodes" ) );\r
+        customizeJMenuItem( _annotate_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _midpoint_root_item = new JMenuItem( "Midpoint-Root" ) );\r
+        customizeJMenuItem( _midpoint_root_item );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _collapse_species_specific_subtrees = new JMenuItem( "Collapse Species-Specific Subtrees" ) );\r
+        customizeJMenuItem( _collapse_species_specific_subtrees );\r
+        _tools_menu\r
+                .add( _collapse_below_threshold = new JMenuItem( "Collapse Branches with Confidence Below Threshold into Multifurcations" ) );\r
+        customizeJMenuItem( _collapse_below_threshold );\r
+        _collapse_below_threshold\r
+                .setToolTipText( "To collapse branches with confidence values below a threshold into multifurcations (in the case of multiple confidences per branch: without at least one confidence value above a threshold)" );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu\r
+                .add( _extract_tax_code_from_node_names_jmi = new JMenuItem( "Extract Taxonomic Data from Node Names" ) );\r
+        customizeJMenuItem( _extract_tax_code_from_node_names_jmi );\r
+        _extract_tax_code_from_node_names_jmi\r
+                .setToolTipText( "To extract SwissProt/Uniprot taxonomic codes (mnemonics) from nodes names in the form of 'xyz_CAEEL', Uniprot/NCBI identifiers form of 'xyz_6239', or scientific names form of 'xyz_Caenorhabditis_elegans'" );\r
+        _tools_menu\r
+                .add( _move_node_names_to_tax_sn_jmi = new JMenuItem( "Transfer Node Names to Taxonomic Scientific Names" ) );\r
+        customizeJMenuItem( _move_node_names_to_tax_sn_jmi );\r
+        _move_node_names_to_tax_sn_jmi.setToolTipText( "To interpret node names as taxonomic scientific names" );\r
+        _tools_menu.add( _move_node_names_to_seq_names_jmi = new JMenuItem( "Transfer Node Names to Sequence Names" ) );\r
+        customizeJMenuItem( _move_node_names_to_seq_names_jmi );\r
+        _move_node_names_to_seq_names_jmi.setToolTipText( "To interpret node names as sequence (protein, gene) names" );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _obtain_seq_information_jmi = new JMenuItem( "Obtain Sequence Information" ) );\r
+        customizeJMenuItem( _obtain_seq_information_jmi );\r
+        _obtain_seq_information_jmi.setToolTipText( "To add additional sequence information" );\r
+        _tools_menu\r
+                .add( _obtain_detailed_taxonomic_information_jmi = new JMenuItem( OBTAIN_DETAILED_TAXONOMIC_INFORMATION ) );\r
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_jmi );\r
+        _obtain_detailed_taxonomic_information_jmi\r
+                .setToolTipText( "To add additional taxonomic information (from UniProt Taxonomy)" );\r
+        _tools_menu\r
+                .add( _obtain_detailed_taxonomic_information_deleting_jmi = new JMenuItem( "Obtain Detailed Taxonomic Information (deletes nodes!)" ) );\r
+        customizeJMenuItem( _obtain_detailed_taxonomic_information_deleting_jmi );\r
+        _obtain_detailed_taxonomic_information_deleting_jmi\r
+                .setToolTipText( "To add additional taxonomic information, deletes nodes for which taxonomy cannot found (from UniProt Taxonomy)" );\r
+        _tools_menu.addSeparator();\r
+        _tools_menu.add( _read_values_jmi = new JMenuItem( "Attach Vector/Expression Values" ) );\r
+        customizeJMenuItem( _read_values_jmi );\r
+        _read_values_jmi.setToolTipText( "To attach vector (e.g. gene expression) values to tree nodes (beta)" );\r
+        _jmenubar.add( _tools_menu );\r
+        _tools_menu.add( _read_seqs_jmi = new JMenuItem( "Attach Molecular Sequences" ) );\r
+        customizeJMenuItem( _read_seqs_jmi );\r
+        _read_seqs_jmi\r
+                .setToolTipText( "To attach molecular sequences to tree nodes (from Fasta-formatted file) (beta)" );\r
+        _jmenubar.add( _tools_menu );\r
+    }\r
+\r
+    @Override\r
+    void close() {\r
+        if ( isUnsavedDataPresent() ) {\r
+            final int r = JOptionPane.showConfirmDialog( this,\r
+                                                         "Exit despite potentially unsaved changes?",\r
+                                                         "Exit?",\r
+                                                         JOptionPane.YES_NO_OPTION );\r
+            if ( r != JOptionPane.YES_OPTION ) {\r
+                return;\r
+            }\r
+        }\r
+        exit();\r
+    }\r
+\r
+    void executeLineageInference() {\r
+        if ( ( _mainpanel.getCurrentPhylogeny() == null ) || ( _mainpanel.getCurrentPhylogeny().isEmpty() ) ) {\r
+            return;\r
+        }\r
+        if ( !_mainpanel.getCurrentPhylogeny().isRooted() ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Phylogeny is not rooted.",\r
+                                           "Cannot infer ancestral taxonomies",\r
+                                           JOptionPane.ERROR_MESSAGE );\r
+            return;\r
+        }\r
+        final AncestralTaxonomyInferrer inferrer = new AncestralTaxonomyInferrer( this,\r
+                                                                                  _mainpanel.getCurrentTreePanel(),\r
+                                                                                  _mainpanel.getCurrentPhylogeny()\r
+                                                                                          .copy() );\r
+        new Thread( inferrer ).start();\r
+    }\r
+\r
+    void exit() {\r
+        removeAllTextFrames();\r
+        _mainpanel.terminate();\r
+        _contentpane.removeAll();\r
+        setVisible( false );\r
+        dispose();\r
+        System.exit( 0 );\r
+    }\r
+\r
+    void readPhylogeniesFromURL() {\r
+        URL url = null;\r
+        Phylogeny[] phys = null;\r
+        final String message = "Please enter a complete URL, for example \"http://purl.org/phylo/treebase/phylows/study/TB2:S15480?format=nexus\"";\r
+        final String url_string = JOptionPane.showInputDialog( this,\r
+                                                               message,\r
+                                                               "Use URL/webservice to obtain a phylogeny",\r
+                                                               JOptionPane.QUESTION_MESSAGE );\r
+        boolean nhx_or_nexus = false;\r
+        if ( ( url_string != null ) && ( url_string.length() > 0 ) ) {\r
+            try {\r
+                url = new URL( url_string );\r
+                PhylogenyParser parser = null;\r
+                if ( url.getHost().toLowerCase().indexOf( "tolweb" ) >= 0 ) {\r
+                    parser = new TolParser();\r
+                }\r
+                else {\r
+                    parser = ParserUtils.createParserDependingOnUrlContents( url, getConfiguration()\r
+                            .isValidatePhyloXmlAgainstSchema() );\r
+                }\r
+                if ( parser instanceof NexusPhylogeniesParser ) {\r
+                    nhx_or_nexus = true;\r
+                }\r
+                else if ( parser instanceof NHXParser ) {\r
+                    nhx_or_nexus = true;\r
+                }\r
+                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                    _mainpanel.getCurrentTreePanel().setWaitCursor();\r
+                }\r
+                else {\r
+                    _mainpanel.setWaitCursor();\r
+                }\r
+                final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();\r
+                phys = factory.create( url.openStream(), parser );\r
+            }\r
+            catch ( final MalformedURLException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Malformed URL: " + url + "\n" + e.getLocalizedMessage(),\r
+                                               "Malformed URL",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            catch ( final IOException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Could not read from " + url + "\n"\r
+                                                       + ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
+                                               "Failed to read URL",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            catch ( final Exception e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               ForesterUtil.wordWrap( e.getLocalizedMessage(), 80 ),\r
+                                               "Unexpected Exception",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            finally {\r
+                if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                    _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+                }\r
+                else {\r
+                    _mainpanel.setArrowCursor();\r
+                }\r
+            }\r
+            if ( ( phys != null ) && ( phys.length > 0 ) ) {\r
+                if ( nhx_or_nexus && getOptions().isInternalNumberAreConfidenceForNhParsing() ) {\r
+                    for( final Phylogeny phy : phys ) {\r
+                        \r
+                        PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );\r
+                    }\r
+                }\r
+                AptxUtil.addPhylogeniesToTabs( phys,\r
+                                               new File( url.getFile() ).getName(),\r
+                                               new File( url.getFile() ).toString(),\r
+                                               getConfiguration(),\r
+                                               getMainPanel() );\r
+                _mainpanel.getControlPanel().showWhole();\r
+            }\r
+        }\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    void setMsa( final Msa msa ) {\r
+        _msa = msa;\r
+    }\r
+\r
+    void setMsaFile( final File msa_file ) {\r
+        _msa_file = msa_file;\r
+    }\r
+\r
+    void setSeqs( final List<Sequence> seqs ) {\r
+        _seqs = seqs;\r
+    }\r
+\r
+    void setSeqsFile( final File seqs_file ) {\r
+        _seqs_file = seqs_file;\r
+    }\r
+\r
+    void writePhylogenyToGraphicsFile( final String file_name, final GraphicsExportType type ) {\r
+        _mainpanel.getCurrentTreePanel().calcParametersForPainting( _mainpanel.getCurrentTreePanel().getWidth(),\r
+                                                                    _mainpanel.getCurrentTreePanel().getHeight(),\r
+                                                                    true );\r
+        String file_written_to = "";\r
+        boolean error = false;\r
+        try {\r
+            file_written_to = AptxUtil.writePhylogenyToGraphicsFile( file_name,\r
+                                                                     _mainpanel.getCurrentTreePanel().getWidth(),\r
+                                                                     _mainpanel.getCurrentTreePanel().getHeight(),\r
+                                                                     _mainpanel.getCurrentTreePanel(),\r
+                                                                     _mainpanel.getControlPanel(),\r
+                                                                     type,\r
+                                                                     getOptions() );\r
+        }\r
+        catch ( final IOException e ) {\r
+            error = true;\r
+            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );\r
+        }\r
+        if ( !error ) {\r
+            if ( ( file_written_to != null ) && ( file_written_to.length() > 0 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Wrote image to: " + file_written_to,\r
+                                               "Graphics Export",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "There was an unknown problem when attempting to write to an image file: \""\r
+                                                       + file_name + "\"",\r
+                                               "Error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+        }\r
+        _contentpane.repaint();\r
+    }\r
+\r
+    private void addExpressionValuesFromFile() {\r
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Need to load evolutionary tree first",\r
+                                           "Can Not Read Expression Values",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+            return;\r
+        }\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _values_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _values_filechooser.showOpenDialog( _contentpane );\r
+        final File file = _values_filechooser.getSelectedFile();\r
+        if ( ( file != null ) && ( file.length() > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            BasicTable<String> t = null;\r
+            try {\r
+                t = BasicTableParser.parse( file, '\t' );\r
+                if ( t.getNumberOfColumns() < 2 ) {\r
+                    t = BasicTableParser.parse( file, ',' );\r
+                }\r
+                if ( t.getNumberOfColumns() < 2 ) {\r
+                    t = BasicTableParser.parse( file, ' ' );\r
+                }\r
+            }\r
+            catch ( final IOException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getMessage(),\r
+                                               "Could Not Read Expression Value Table",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( t.getNumberOfColumns() < 2 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Table contains " + t.getNumberOfColumns() + " column(s)",\r
+                                               "Problem with Expression Value Table",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( t.getNumberOfRows() < 1 ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Table contains zero rows",\r
+                                               "Problem with Expression Value Table",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( t.getNumberOfRows() != phy.getNumberOfExternalNodes() ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Table contains " + t.getNumberOfRows() + " rows, but tree contains "\r
+                                                       + phy.getNumberOfExternalNodes() + " external nodes",\r
+                                               "Warning",\r
+                                               JOptionPane.WARNING_MESSAGE );\r
+            }\r
+            final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
+            int not_found = 0;\r
+            for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+                final PhylogenyNode node = iter.next();\r
+                final String node_name = node.getName();\r
+                if ( !ForesterUtil.isEmpty( node_name ) ) {\r
+                    int row = -1;\r
+                    try {\r
+                        row = t.findRow( node_name );\r
+                    }\r
+                    catch ( final IllegalArgumentException e ) {\r
+                        JOptionPane\r
+                                .showMessageDialog( this,\r
+                                                    e.getMessage(),\r
+                                                    "Error Mapping Node Identifiers to Expression Value Identifiers",\r
+                                                    JOptionPane.ERROR_MESSAGE );\r
+                        return;\r
+                    }\r
+                    if ( row < 0 ) {\r
+                        if ( node.isExternal() ) {\r
+                            not_found++;\r
+                        }\r
+                        continue;\r
+                    }\r
+                    final List<Double> l = new ArrayList<Double>();\r
+                    for( int col = 1; col < t.getNumberOfColumns(); ++col ) {\r
+                        double d = -100;\r
+                        try {\r
+                            d = Double.parseDouble( t.getValueAsString( col, row ) );\r
+                        }\r
+                        catch ( final NumberFormatException e ) {\r
+                            JOptionPane.showMessageDialog( this,\r
+                                                           "Could not parse \"" + t.getValueAsString( col, row )\r
+                                                                   + "\" into a decimal value",\r
+                                                           "Issue with Expression Value Table",\r
+                                                           JOptionPane.ERROR_MESSAGE );\r
+                            return;\r
+                        }\r
+                        stats.addValue( d );\r
+                        l.add( d );\r
+                    }\r
+                    if ( !l.isEmpty() ) {\r
+                        if ( node.getNodeData().getProperties() != null ) {\r
+                            node.getNodeData().getProperties()\r
+                                    .removePropertiesWithGivenReferencePrefix( PhyloXmlUtil.VECTOR_PROPERTY_REF );\r
+                        }\r
+                        node.getNodeData().setVector( l );\r
+                    }\r
+                }\r
+            }\r
+            if ( not_found > 0 ) {\r
+                JOptionPane.showMessageDialog( this, "Could not fine expression values for " + not_found\r
+                        + " external node(s)", "Warning", JOptionPane.WARNING_MESSAGE );\r
+            }\r
+            getCurrentTreePanel().setStatisticsForExpressionValues( stats );\r
+        }\r
+    }\r
+\r
+    private void addSequencesFromFile() {\r
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null ) ) {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "Need to load evolutionary tree first",\r
+                                           "Can Not Read Sequences",\r
+                                           JOptionPane.WARNING_MESSAGE );\r
+            return;\r
+        }\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _sequences_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _sequences_filechooser.showOpenDialog( _contentpane );\r
+        final File file = _sequences_filechooser.getSelectedFile();\r
+        List<Sequence> seqs = null;\r
+        if ( ( file != null ) && !file.isDirectory() && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            try {\r
+                if ( FastaParser.isLikelyFasta( new FileInputStream( file ) ) ) {\r
+                    seqs = FastaParser.parse( new FileInputStream( file ) );\r
+                }\r
+                else {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Format does not appear to be Fasta",\r
+                                                   "Multiple sequence file format error",\r
+                                                   JOptionPane.ERROR_MESSAGE );\r
+                    return;\r
+                }\r
+            }\r
+            catch ( final MsaFormatException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Multiple sequence file format error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final IOException e ) {\r
+                setArrowCursor();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Failed to read multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            catch ( final Exception e ) {\r
+                setArrowCursor();\r
+                e.printStackTrace();\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "Unexpected error during reading of multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                return;\r
+            }\r
+            if ( ( seqs == null ) || ( seqs.size() < 1 ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Multiple sequence file is empty",\r
+                                               "Empty multiple sequence file",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+                setArrowCursor();\r
+                return;\r
+            }\r
+        }\r
+        if ( seqs != null ) {\r
+            for( final Sequence seq : seqs ) {\r
+                System.out.println( seq.getIdentifier() );\r
+            }\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            int total_counter = 0;\r
+            int attached_counter = 0;\r
+            for( final Sequence seq : seqs ) {\r
+                ++total_counter;\r
+                final String seq_name = seq.getIdentifier();\r
+                if ( !ForesterUtil.isEmpty( seq_name ) ) {\r
+                    List<PhylogenyNode> nodes = phy.getNodesViaSequenceName( seq_name );\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodesViaSequenceSymbol( seq_name );\r
+                    }\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodesViaGeneName( seq_name );\r
+                    }\r
+                    if ( nodes.isEmpty() ) {\r
+                        nodes = phy.getNodes( seq_name );\r
+                    }\r
+                    if ( nodes.size() > 1 ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Sequence name \"" + seq_name + "\" is not unique",\r
+                                                       "Sequence name not unique",\r
+                                                       JOptionPane.ERROR_MESSAGE );\r
+                        setArrowCursor();\r
+                        return;\r
+                    }\r
+                    final String[] a = seq_name.split( "\\s" );\r
+                    if ( nodes.isEmpty() && ( a.length > 1 ) ) {\r
+                        final String seq_name_split = a[ 0 ];\r
+                        nodes = phy.getNodesViaSequenceName( seq_name_split );\r
+                        if ( nodes.isEmpty() ) {\r
+                            nodes = phy.getNodesViaSequenceSymbol( seq_name_split );\r
+                        }\r
+                        if ( nodes.isEmpty() ) {\r
+                            nodes = phy.getNodes( seq_name_split );\r
+                        }\r
+                        if ( nodes.size() > 1 ) {\r
+                            JOptionPane.showMessageDialog( this, "Split sequence name \"" + seq_name_split\r
+                                    + "\" is not unique", "Sequence name not unique", JOptionPane.ERROR_MESSAGE );\r
+                            setArrowCursor();\r
+                            return;\r
+                        }\r
+                    }\r
+                    if ( nodes.size() == 1 ) {\r
+                        ++attached_counter;\r
+                        final PhylogenyNode n = nodes.get( 0 );\r
+                        if ( !n.getNodeData().isHasSequence() ) {\r
+                            n.getNodeData().addSequence( new org.forester.phylogeny.data.Sequence() );\r
+                        }\r
+                        n.getNodeData().getSequence().setMolecularSequence( seq.getMolecularSequenceAsString() );\r
+                        if ( ForesterUtil.isEmpty( n.getNodeData().getSequence().getName() ) ) {\r
+                            n.getNodeData().getSequence().setName( seq_name );\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+            if ( attached_counter > 0 ) {\r
+                int ext_nodes = 0;\r
+                int ext_nodes_with_seq = 0;\r
+                for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
+                    ++ext_nodes;\r
+                    final PhylogenyNode n = iter.next();\r
+                    if ( n.getNodeData().isHasSequence()\r
+                            && !ForesterUtil.isEmpty( n.getNodeData().getSequence().getMolecularSequence() ) ) {\r
+                        ++ext_nodes_with_seq;\r
+                    }\r
+                }\r
+                final String s;\r
+                if ( ext_nodes == ext_nodes_with_seq ) {\r
+                    s = "All " + ext_nodes_with_seq + " external nodes now have a molecular sequence attached to them.";\r
+                }\r
+                else {\r
+                    s = ext_nodes_with_seq + " out of " + ext_nodes\r
+                            + " external nodes now have a molecular sequence attached to them.";\r
+                }\r
+                if ( ( attached_counter == total_counter ) && ( ext_nodes == ext_nodes_with_seq ) ) {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Attached all " + total_counter + " sequences to tree nodes.\n" + s,\r
+                                                   "All sequences attached",\r
+                                                   JOptionPane.INFORMATION_MESSAGE );\r
+                }\r
+                else {\r
+                    JOptionPane.showMessageDialog( this, "Attached " + attached_counter\r
+                            + " sequences out of a total of " + total_counter + " sequences.\n" + s, attached_counter\r
+                            + " sequences attached", JOptionPane.WARNING_MESSAGE );\r
+                }\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this, "No maching tree node for any of the " + total_counter\r
+                        + " sequences", "Could not attach any sequences", JOptionPane.ERROR_MESSAGE );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void choosePdfWidth() {\r
+        final String s = ( String ) JOptionPane.showInputDialog( this,\r
+                                                                 "Please enter the default line width for PDF export.\n"\r
+                                                                         + "[current value: "\r
+                                                                         + getOptions().getPrintLineWidth() + "]\n",\r
+                                                                 "Line Width for PDF Export",\r
+                                                                 JOptionPane.QUESTION_MESSAGE,\r
+                                                                 null,\r
+                                                                 null,\r
+                                                                 getOptions().getPrintLineWidth() );\r
+        if ( !ForesterUtil.isEmpty( s ) ) {\r
+            boolean success = true;\r
+            float f = 0.0f;\r
+            final String m_str = s.trim();\r
+            if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                try {\r
+                    f = Float.parseFloat( m_str );\r
+                }\r
+                catch ( final Exception ex ) {\r
+                    success = false;\r
+                }\r
+            }\r
+            else {\r
+                success = false;\r
+            }\r
+            if ( success && ( f > 0.0 ) ) {\r
+                getOptions().setPrintLineWidth( f );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void choosePrintSize() {\r
+        final String s = ( String ) JOptionPane.showInputDialog( this,\r
+                                                                 "Please enter values for width and height,\nseparated by a comma.\n"\r
+                                                                         + "[current values: "\r
+                                                                         + getOptions().getPrintSizeX() + ", "\r
+                                                                         + getOptions().getPrintSizeY() + "]\n"\r
+                                                                         + "[A4: " + Constants.A4_SIZE_X + ", "\r
+                                                                         + Constants.A4_SIZE_Y + "]\n" + "[US Letter: "\r
+                                                                         + Constants.US_LETTER_SIZE_X + ", "\r
+                                                                         + Constants.US_LETTER_SIZE_Y + "]",\r
+                                                                 "Default Size for Graphics Export",\r
+                                                                 JOptionPane.QUESTION_MESSAGE,\r
+                                                                 null,\r
+                                                                 null,\r
+                                                                 getOptions().getPrintSizeX() + ", "\r
+                                                                         + getOptions().getPrintSizeY() );\r
+        if ( !ForesterUtil.isEmpty( s ) && ( s.indexOf( ',' ) > 0 ) ) {\r
+            boolean success = true;\r
+            int x = 0;\r
+            int y = 0;\r
+            final String[] str_ary = s.split( "," );\r
+            if ( str_ary.length == 2 ) {\r
+                final String x_str = str_ary[ 0 ].trim();\r
+                final String y_str = str_ary[ 1 ].trim();\r
+                if ( !ForesterUtil.isEmpty( x_str ) && !ForesterUtil.isEmpty( y_str ) ) {\r
+                    try {\r
+                        x = Integer.parseInt( x_str );\r
+                        y = Integer.parseInt( y_str );\r
+                    }\r
+                    catch ( final Exception ex ) {\r
+                        success = false;\r
+                    }\r
+                }\r
+                else {\r
+                    success = false;\r
+                }\r
+            }\r
+            else {\r
+                success = false;\r
+            }\r
+            if ( success && ( x > 1 ) && ( y > 1 ) ) {\r
+                getOptions().setPrintSizeX( x );\r
+                getOptions().setPrintSizeY( y );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void closeCurrentPane() {\r
+        if ( getMainPanel().getCurrentTreePanel() != null ) {\r
+            if ( getMainPanel().getCurrentTreePanel().isEdited() ) {\r
+                final int r = JOptionPane.showConfirmDialog( this,\r
+                                                             "Close tab despite potentially unsaved changes?",\r
+                                                             "Close Tab?",\r
+                                                             JOptionPane.YES_NO_OPTION );\r
+                if ( r != JOptionPane.YES_OPTION ) {\r
+                    return;\r
+                }\r
+            }\r
+            getMainPanel().closeCurrentPane();\r
+            activateSaveAllIfNeeded();\r
+        }\r
+    }\r
+\r
+    private void collapse( final Phylogeny phy, final double m ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        final List<PhylogenyNode> to_be_removed = new ArrayList<PhylogenyNode>();\r
+        double min_support = Double.MAX_VALUE;\r
+        boolean conf_present = false;\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                final List<Confidence> c = n.getBranchData().getConfidences();\r
+                if ( ( c != null ) && ( c.size() > 0 ) ) {\r
+                    conf_present = true;\r
+                    double max = 0;\r
+                    for( final Confidence confidence : c ) {\r
+                        if ( confidence.getValue() > max ) {\r
+                            max = confidence.getValue();\r
+                        }\r
+                    }\r
+                    if ( max < getMinNotCollapseConfidenceValue() ) {\r
+                        to_be_removed.add( n );\r
+                    }\r
+                    if ( max < min_support ) {\r
+                        min_support = max;\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        if ( conf_present ) {\r
+            for( final PhylogenyNode node : to_be_removed ) {\r
+                PhylogenyMethods.removeNode( node, phy );\r
+            }\r
+            if ( to_be_removed.size() > 0 ) {\r
+                phy.externalNodesHaveChanged();\r
+                phy.clearHashIdToNodeMap();\r
+                phy.recalculateNumberOfExternalDescendants( true );\r
+                getCurrentTreePanel().resetNodeIdToDistToLeafMap();\r
+                getCurrentTreePanel().updateSetOfCollapsedExternalNodes();\r
+                getCurrentTreePanel().calculateLongestExtNodeInfo();\r
+                getCurrentTreePanel().setNodeInPreorderToNull();\r
+                getCurrentTreePanel().recalculateMaxDistanceToRoot();\r
+                getCurrentTreePanel().resetPreferredSize();\r
+                getCurrentTreePanel().setEdited( true );\r
+                getCurrentTreePanel().repaint();\r
+                repaint();\r
+            }\r
+            if ( to_be_removed.size() > 0 ) {\r
+                JOptionPane.showMessageDialog( this, "Collapsed " + to_be_removed.size()\r
+                        + " branches with\nconfidence values below " + getMinNotCollapseConfidenceValue(), "Collapsed "\r
+                        + to_be_removed.size() + " branches", JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this, "No branch collapsed,\nminimum confidence value per branch is "\r
+                        + min_support, "No branch collapsed", JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+        }\r
+        else {\r
+            JOptionPane.showMessageDialog( this,\r
+                                           "No branch collapsed because no confidence values present",\r
+                                           "No confidence values present",\r
+                                           JOptionPane.INFORMATION_MESSAGE );\r
+        }\r
+    }\r
+\r
+    private void collapseBelowThreshold() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final String s = ( String ) JOptionPane.showInputDialog( this,\r
+                                                                         "Please enter the minimum confidence value\n",\r
+                                                                         "Minimal Confidence Value",\r
+                                                                         JOptionPane.QUESTION_MESSAGE,\r
+                                                                         null,\r
+                                                                         null,\r
+                                                                         getMinNotCollapseConfidenceValue() );\r
+                if ( !ForesterUtil.isEmpty( s ) ) {\r
+                    boolean success = true;\r
+                    double m = 0.0;\r
+                    final String m_str = s.trim();\r
+                    if ( !ForesterUtil.isEmpty( m_str ) ) {\r
+                        try {\r
+                            m = Double.parseDouble( m_str );\r
+                        }\r
+                        catch ( final Exception ex ) {\r
+                            success = false;\r
+                        }\r
+                    }\r
+                    else {\r
+                        success = false;\r
+                    }\r
+                    if ( success && ( m >= 0.0 ) ) {\r
+                        setMinNotCollapseConfidenceValue( m );\r
+                        collapse( phy, m );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    private PhyloXmlParser createPhyloXmlParser() {\r
+        PhyloXmlParser xml_parser = null;\r
+        if ( getConfiguration().isValidatePhyloXmlAgainstSchema() ) {\r
+            try {\r
+                xml_parser = PhyloXmlParser.createPhyloXmlParserXsdValidating();\r
+            }\r
+            catch ( final Exception e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               e.getLocalizedMessage(),\r
+                                               "failed to create validating XML parser",\r
+                                               JOptionPane.WARNING_MESSAGE );\r
+            }\r
+        }\r
+        if ( xml_parser == null ) {\r
+            xml_parser = PhyloXmlParser.createPhyloXmlParser();\r
+        }\r
+        return xml_parser;\r
+    }\r
+\r
+    private void executePhyleneticInference( final boolean from_unaligned_seqs ) {\r
+        final PhyloInferenceDialog dialog = new PhyloInferenceDialog( this,\r
+                                                                      getPhylogeneticInferenceOptions(),\r
+                                                                      from_unaligned_seqs );\r
+        dialog.activate();\r
+        if ( dialog.getValue() == JOptionPane.OK_OPTION ) {\r
+            if ( !from_unaligned_seqs ) {\r
+                if ( getMsa() != null ) {\r
+                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getMsa(),\r
+                                                                                    getPhylogeneticInferenceOptions()\r
+                                                                                            .copy(), this );\r
+                    new Thread( inferrer ).start();\r
+                }\r
+                else {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "No multiple sequence alignment selected",\r
+                                                   "Phylogenetic Inference Not Launched",\r
+                                                   JOptionPane.WARNING_MESSAGE );\r
+                }\r
+            }\r
+            else {\r
+                if ( getSeqs() != null ) {\r
+                    final PhylogeneticInferrer inferrer = new PhylogeneticInferrer( getSeqs(),\r
+                                                                                    getPhylogeneticInferenceOptions()\r
+                                                                                            .copy(), this );\r
+                    new Thread( inferrer ).start();\r
+                }\r
+                else {\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "No input sequences selected",\r
+                                                   "Phylogenetic Inference Not Launched",\r
+                                                   JOptionPane.WARNING_MESSAGE );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    private void extractTaxDataFromNodeNames() throws PhyloXmlDataFormatException {\r
+        final StringBuilder sb = new StringBuilder();\r
+        final StringBuilder sb_failed = new StringBuilder();\r
+        int counter = 0;\r
+        int counter_failed = 0;\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final PhylogenyNodeIterator it = phy.iteratorExternalForward();\r
+                while ( it.hasNext() ) {\r
+                    final PhylogenyNode n = it.next();\r
+                    final String name = n.getName().trim();\r
+                    if ( !ForesterUtil.isEmpty( name ) ) {\r
+                        final String nt = ParserUtils.extractTaxonomyDataFromNodeName( n,\r
+                                                                                       TAXONOMY_EXTRACTION.AGGRESSIVE );\r
+                        if ( !ForesterUtil.isEmpty( nt ) ) {\r
+                            if ( counter < 15 ) {\r
+                                sb.append( name + ": " + nt + "\n" );\r
+                            }\r
+                            else if ( counter == 15 ) {\r
+                                sb.append( "...\n" );\r
+                            }\r
+                            counter++;\r
+                        }\r
+                        else {\r
+                            if ( counter_failed < 15 ) {\r
+                                sb_failed.append( name + "\n" );\r
+                            }\r
+                            else if ( counter_failed == 15 ) {\r
+                                sb_failed.append( "...\n" );\r
+                            }\r
+                            counter_failed++;\r
+                        }\r
+                    }\r
+                }\r
+                if ( counter > 0 ) {\r
+                    String failed = "";\r
+                    String all = "all ";\r
+                    if ( counter_failed > 0 ) {\r
+                        all = "";\r
+                        failed = "\nCould not extract taxonomic data for " + counter_failed\r
+                                + " named external nodes:\n" + sb_failed;\r
+                    }\r
+                    JOptionPane.showMessageDialog( this,\r
+                                                   "Extracted taxonomic data from " + all + counter\r
+                                                           + " named external nodes:\n" + sb.toString() + failed,\r
+                                                   "Taxonomic Data Extraction Completed",\r
+                                                   counter_failed > 0 ? JOptionPane.WARNING_MESSAGE\r
+                                                           : JOptionPane.INFORMATION_MESSAGE );\r
+                }\r
+                else {\r
+                    JOptionPane\r
+                            .showMessageDialog( this,\r
+                                                "Could not extract any taxonomic data.\nMaybe node names are empty\n"\r
+                                                        + "or not in the forms \"XYZ_CAEEL\", \"XYZ_6239\", or \"XYZ_Caenorhabditis_elegans\"\n"\r
+                                                        + "or nodes already have taxonomic data?\n",\r
+                                                "No Taxonomic Data Extracted",\r
+                                                JOptionPane.ERROR_MESSAGE );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    private ControlPanel getControlPanel() {\r
+        return getMainPanel().getControlPanel();\r
+    }\r
+\r
+    private File getCurrentDir() {\r
+        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {\r
+            if ( ForesterUtil.isWindows() ) {\r
+                try {\r
+                    _current_dir = new File( WindowsUtils.getCurrentUserDesktopPath() );\r
+                }\r
+                catch ( final Exception e ) {\r
+                    _current_dir = null;\r
+                }\r
+            }\r
+        }\r
+        if ( ( _current_dir == null ) || !_current_dir.canRead() ) {\r
+            if ( System.getProperty( "user.home" ) != null ) {\r
+                _current_dir = new File( System.getProperty( "user.home" ) );\r
+            }\r
+            else if ( System.getProperty( "user.dir" ) != null ) {\r
+                _current_dir = new File( System.getProperty( "user.dir" ) );\r
+            }\r
+        }\r
+        return _current_dir;\r
+    }\r
+\r
+    private double getMinNotCollapseConfidenceValue() {\r
+        return _min_not_collapse;\r
+    }\r
+\r
+    private PhylogeneticInferenceOptions getPhylogeneticInferenceOptions() {\r
+        if ( _phylogenetic_inference_options == null ) {\r
+            _phylogenetic_inference_options = new PhylogeneticInferenceOptions();\r
+        }\r
+        return _phylogenetic_inference_options;\r
+    }\r
+\r
+    private boolean isUnsavedDataPresent() {\r
+        final List<TreePanel> tps = getMainPanel().getTreePanels();\r
+        for( final TreePanel tp : tps ) {\r
+            if ( tp.isEdited() ) {\r
+                return true;\r
+            }\r
+        }\r
+        return false;\r
+    }\r
+\r
+    private void moveNodeNamesToSeqNames() throws PhyloXmlDataFormatException {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                PhylogenyMethods\r
+                        .transferNodeNameToField( phy, PhylogenyMethods.PhylogenyNodeField.SEQUENCE_NAME, false );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void moveNodeNamesToTaxSn() throws PhyloXmlDataFormatException {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                PhylogenyMethods.transferNodeNameToField( phy,\r
+                                                          PhylogenyMethods.PhylogenyNodeField.TAXONOMY_SCIENTIFIC_NAME,\r
+                                                          false );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void newTree() {\r
+        final Phylogeny[] phys = new Phylogeny[ 1 ];\r
+        final Phylogeny phy = new Phylogeny();\r
+        final PhylogenyNode node = new PhylogenyNode();\r
+        phy.setRoot( node );\r
+        phy.setRooted( true );\r
+        phys[ 0 ] = phy;\r
+        AptxUtil.addPhylogeniesToTabs( phys, "", "", getConfiguration(), getMainPanel() );\r
+        _mainpanel.getControlPanel().showWhole();\r
+        _mainpanel.getCurrentTreePanel().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+        _mainpanel.getOptions().setPhylogenyGraphicsType( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+        if ( getMainPanel().getMainFrame() == null ) {\r
+            // Must be "E" applet version.\r
+            ( ( ArchaeopteryxE ) ( ( MainPanelApplets ) getMainPanel() ).getApplet() )\r
+                    .setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+        }\r
+        else {\r
+            getMainPanel().getMainFrame().setSelectedTypeInTypeMenu( PHYLOGENY_GRAPHICS_TYPE.RECTANGULAR );\r
+        }\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    private void obtainDetailedTaxonomicInformation() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final TaxonomyDataManager t = new TaxonomyDataManager( this,\r
+                                                                       _mainpanel.getCurrentTreePanel(),\r
+                                                                       phy.copy(),\r
+                                                                       false,\r
+                                                                       true );\r
+                new Thread( t ).start();\r
+            }\r
+        }\r
+    }\r
+\r
+    private void obtainDetailedTaxonomicInformationDelete() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final TaxonomyDataManager t = new TaxonomyDataManager( this,\r
+                                                                       _mainpanel.getCurrentTreePanel(),\r
+                                                                       phy.copy(),\r
+                                                                       true,\r
+                                                                       true );\r
+                new Thread( t ).start();\r
+            }\r
+        }\r
+    }\r
+\r
+    private void obtainSequenceInformation() {\r
+        if ( getCurrentTreePanel() != null ) {\r
+            final Phylogeny phy = getCurrentTreePanel().getPhylogeny();\r
+            if ( ( phy != null ) && !phy.isEmpty() ) {\r
+                final SequenceDataRetriver u = new SequenceDataRetriver( this,\r
+                                                                         _mainpanel.getCurrentTreePanel(),\r
+                                                                         phy.copy() );\r
+                new Thread( u ).start();\r
+            }\r
+        }\r
+    }\r
+\r
+    private void print() {\r
+        if ( ( getCurrentTreePanel() == null ) || ( getCurrentTreePanel().getPhylogeny() == null )\r
+                || getCurrentTreePanel().getPhylogeny().isEmpty() ) {\r
+            return;\r
+        }\r
+        if ( !getOptions().isPrintUsingActualSize() ) {\r
+            getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX() - 80,\r
+                                                             getOptions().getPrintSizeY() - 140,\r
+                                                             true );\r
+            getCurrentTreePanel().resetPreferredSize();\r
+            getCurrentTreePanel().repaint();\r
+        }\r
+        final String job_name = Constants.PRG_NAME;\r
+        boolean error = false;\r
+        String printer_name = null;\r
+        try {\r
+            printer_name = Printer.print( getCurrentTreePanel(), job_name );\r
+        }\r
+        catch ( final Exception e ) {\r
+            error = true;\r
+            JOptionPane.showMessageDialog( this, e.getMessage(), "Printing Error", JOptionPane.ERROR_MESSAGE );\r
+        }\r
+        if ( !error && ( printer_name != null ) ) {\r
+            String msg = "Printing data sent to printer";\r
+            if ( printer_name.length() > 1 ) {\r
+                msg += " [" + printer_name + "]";\r
+            }\r
+            JOptionPane.showMessageDialog( this, msg, "Printing...", JOptionPane.INFORMATION_MESSAGE );\r
+        }\r
+        if ( !getOptions().isPrintUsingActualSize() ) {\r
+            getControlPanel().showWhole();\r
+        }\r
+    }\r
+\r
+    private void printPhylogenyToPdf( final String file_name ) {\r
+        if ( !getOptions().isPrintUsingActualSize() ) {\r
+            getCurrentTreePanel().calcParametersForPainting( getOptions().getPrintSizeX(),\r
+                                                             getOptions().getPrintSizeY(),\r
+                                                             true );\r
+            getCurrentTreePanel().resetPreferredSize();\r
+            getCurrentTreePanel().repaint();\r
+        }\r
+        String pdf_written_to = "";\r
+        boolean error = false;\r
+        try {\r
+            if ( getOptions().isPrintUsingActualSize() ) {\r
+                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name,\r
+                                                                  getCurrentTreePanel(),\r
+                                                                  getCurrentTreePanel().getWidth(),\r
+                                                                  getCurrentTreePanel().getHeight() );\r
+            }\r
+            else {\r
+                pdf_written_to = PdfExporter.writePhylogenyToPdf( file_name, getCurrentTreePanel(), getOptions()\r
+                        .getPrintSizeX(), getOptions().getPrintSizeY() );\r
+            }\r
+        }\r
+        catch ( final IOException e ) {\r
+            error = true;\r
+            JOptionPane.showMessageDialog( this, e.getMessage(), "Error", JOptionPane.ERROR_MESSAGE );\r
+        }\r
+        if ( !error ) {\r
+            if ( !ForesterUtil.isEmpty( pdf_written_to ) ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Wrote PDF to: " + pdf_written_to,\r
+                                               "Information",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            else {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "There was an unknown problem when attempting to write to PDF file: \""\r
+                                                       + file_name + "\"",\r
+                                               "Error",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+        }\r
+        if ( !getOptions().isPrintUsingActualSize() ) {\r
+            getControlPanel().showWhole();\r
+        }\r
+    }\r
+\r
+    private void readPhylogeniesFromFile() {\r
+        boolean exception = false;\r
+        Phylogeny[] phys = null;\r
+        // Set an initial directory if none set yet\r
+        final File my_dir = getCurrentDir();\r
+        _open_filechooser.setMultiSelectionEnabled( true );\r
+        // Open file-open dialog and set current directory\r
+        if ( my_dir != null ) {\r
+            _open_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _open_filechooser.showOpenDialog( _contentpane );\r
+        // All done: get the file\r
+        final File[] files = _open_filechooser.getSelectedFiles();\r
+        setCurrentDir( _open_filechooser.getCurrentDirectory() );\r
+        boolean nhx_or_nexus = false;\r
+        if ( ( files != null ) && ( files.length > 0 ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            for( final File file : files ) {\r
+                if ( ( file != null ) && !file.isDirectory() ) {\r
+                    if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                        _mainpanel.getCurrentTreePanel().setWaitCursor();\r
+                    }\r
+                    else {\r
+                        _mainpanel.setWaitCursor();\r
+                    }\r
+                    if ( ( _open_filechooser.getFileFilter() == MainFrameApplication.nhfilter )\r
+                            || ( _open_filechooser.getFileFilter() == MainFrameApplication.nhxfilter ) ) {\r
+                        try {\r
+                            final NHXParser nhx = new NHXParser();\r
+                            setSpecialOptionsForNhxParser( nhx );\r
+                            phys = PhylogenyMethods.readPhylogenies( nhx, file );\r
+                            nhx_or_nexus = true;\r
+                        }\r
+                        catch ( final Exception e ) {\r
+                            exception = true;\r
+                            exceptionOccuredDuringOpenFile( e );\r
+                        }\r
+                    }\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
+                        warnIfNotPhyloXmlValidation( getConfiguration() );\r
+                        try {\r
+                            final PhyloXmlParser xml_parser = createPhyloXmlParser();\r
+                            phys = PhylogenyMethods.readPhylogenies( xml_parser, file );\r
+                        }\r
+                        catch ( final Exception e ) {\r
+                            exception = true;\r
+                            exceptionOccuredDuringOpenFile( e );\r
+                        }\r
+                    }\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.tolfilter ) {\r
+                        try {\r
+                            phys = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
+                        }\r
+                        catch ( final Exception e ) {\r
+                            exception = true;\r
+                            exceptionOccuredDuringOpenFile( e );\r
+                        }\r
+                    }\r
+                    else if ( _open_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {\r
+                        try {\r
+                            final NexusPhylogeniesParser nex = new NexusPhylogeniesParser();\r
+                            setSpecialOptionsForNexParser( nex );\r
+                            phys = PhylogenyMethods.readPhylogenies( nex, file );\r
+                            nhx_or_nexus = true;\r
+                        }\r
+                        catch ( final Exception e ) {\r
+                            exception = true;\r
+                            exceptionOccuredDuringOpenFile( e );\r
+                        }\r
+                    }\r
+                    // "*.*":\r
+                    else {\r
+                        try {\r
+                            final PhylogenyParser parser = ParserUtils\r
+                                    .createParserDependingOnFileType( file, getConfiguration()\r
+                                            .isValidatePhyloXmlAgainstSchema() );\r
+                            if ( parser instanceof NexusPhylogeniesParser ) {\r
+                                final NexusPhylogeniesParser nex = ( NexusPhylogeniesParser ) parser;\r
+                                setSpecialOptionsForNexParser( nex );\r
+                                nhx_or_nexus = true;\r
+                            }\r
+                            else if ( parser instanceof NHXParser ) {\r
+                                final NHXParser nhx = ( NHXParser ) parser;\r
+                                setSpecialOptionsForNhxParser( nhx );\r
+                                nhx_or_nexus = true;\r
+                            }\r
+                            else if ( parser instanceof PhyloXmlParser ) {\r
+                                warnIfNotPhyloXmlValidation( getConfiguration() );\r
+                            }\r
+                            phys = PhylogenyMethods.readPhylogenies( parser, file );\r
+                        }\r
+                        catch ( final Exception e ) {\r
+                            exception = true;\r
+                            exceptionOccuredDuringOpenFile( e );\r
+                        }\r
+                    }\r
+                    if ( _mainpanel.getCurrentTreePanel() != null ) {\r
+                        _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+                    }\r
+                    else {\r
+                        _mainpanel.setArrowCursor();\r
+                    }\r
+                    if ( !exception && ( phys != null ) && ( phys.length > 0 ) ) {\r
+                        boolean one_desc = false;\r
+                        if ( nhx_or_nexus ) {\r
+                            for( final Phylogeny phy : phys ) {\r
+                                if ( getOptions().isInternalNumberAreConfidenceForNhParsing() ) {\r
+                                    PhylogenyMethods.transferInternalNodeNamesToConfidence( phy, "" );\r
+                                }\r
+                                if ( PhylogenyMethods.getMinimumDescendentsPerInternalNodes( phy ) == 1 ) {\r
+                                    one_desc = true;\r
+                                    break;\r
+                                }\r
+                            }\r
+                        }\r
+                        AptxUtil.addPhylogeniesToTabs( phys,\r
+                                                       file.getName(),\r
+                                                       file.getAbsolutePath(),\r
+                                                       getConfiguration(),\r
+                                                       getMainPanel() );\r
+                        _mainpanel.getControlPanel().showWhole();\r
+                        if ( nhx_or_nexus && one_desc ) {\r
+                            JOptionPane\r
+                                    .showMessageDialog( this,\r
+                                                        "One or more trees contain (a) node(s) with one descendant, "\r
+                                                                + ForesterUtil.LINE_SEPARATOR\r
+                                                                + "possibly indicating illegal parentheses within node names.",\r
+                                                        "Warning: Possible Error in New Hampshire Formatted Data",\r
+                                                        JOptionPane.WARNING_MESSAGE );\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        activateSaveAllIfNeeded();\r
+        System.gc();\r
+    }\r
+\r
+    private void readSpeciesTreeFromFile() {\r
+        Phylogeny t = null;\r
+        boolean exception = false;\r
+        final File my_dir = getCurrentDir();\r
+        _open_filechooser_for_species_tree.setSelectedFile( new File( "" ) );\r
+        if ( my_dir != null ) {\r
+            _open_filechooser_for_species_tree.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _open_filechooser_for_species_tree.showOpenDialog( _contentpane );\r
+        final File file = _open_filechooser_for_species_tree.getSelectedFile();\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
+                            .createPhyloXmlParserXsdValidating(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            else if ( _open_filechooser_for_species_tree.getFileFilter() == MainFrameApplication.tolfilter ) {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( new TolParser(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            // "*.*":\r
+            else {\r
+                try {\r
+                    final Phylogeny[] trees = PhylogenyMethods.readPhylogenies( PhyloXmlParser\r
+                            .createPhyloXmlParserXsdValidating(), file );\r
+                    t = trees[ 0 ];\r
+                }\r
+                catch ( final Exception e ) {\r
+                    exception = true;\r
+                    exceptionOccuredDuringOpenFile( e );\r
+                }\r
+            }\r
+            if ( !exception && ( t != null ) && !t.isRooted() ) {\r
+                exception = true;\r
+                t = null;\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Species tree is not rooted",\r
+                                               "Species tree not loaded",\r
+                                               JOptionPane.ERROR_MESSAGE );\r
+            }\r
+            if ( !exception && ( t != null ) ) {\r
+                final Set<Taxonomy> tax_set = new HashSet<Taxonomy>();\r
+                for( final PhylogenyNodeIterator it = t.iteratorExternalForward(); it.hasNext(); ) {\r
+                    final PhylogenyNode node = it.next();\r
+                    if ( !node.getNodeData().isHasTaxonomy() ) {\r
+                        exception = true;\r
+                        t = null;\r
+                        JOptionPane\r
+                                .showMessageDialog( this,\r
+                                                    "Species tree contains external node(s) without taxonomy information",\r
+                                                    "Species tree not loaded",\r
+                                                    JOptionPane.ERROR_MESSAGE );\r
+                        break;\r
+                    }\r
+                    else {\r
+                        if ( tax_set.contains( node.getNodeData().getTaxonomy() ) ) {\r
+                            exception = true;\r
+                            t = null;\r
+                            JOptionPane.showMessageDialog( this,\r
+                                                           "Taxonomy ["\r
+                                                                   + node.getNodeData().getTaxonomy().asSimpleText()\r
+                                                                   + "] is not unique in species tree",\r
+                                                           "Species tree not loaded",\r
+                                                           JOptionPane.ERROR_MESSAGE );\r
+                            break;\r
+                        }\r
+                        else {\r
+                            tax_set.add( node.getNodeData().getTaxonomy() );\r
+                        }\r
+                    }\r
+                }\r
+            }\r
+            if ( !exception && ( t != null ) ) {\r
+                setSpeciesTree( t );\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Species tree successfully loaded",\r
+                                               "Species tree loaded",\r
+                                               JOptionPane.INFORMATION_MESSAGE );\r
+            }\r
+            _contentpane.repaint();\r
+            System.gc();\r
+        }\r
+    }\r
+\r
+    private void setArrowCursor() {\r
+        try {\r
+            _mainpanel.getCurrentTreePanel().setArrowCursor();\r
+        }\r
+        catch ( final Exception ex ) {\r
+            // Do nothing.\r
+        }\r
+    }\r
+\r
+    private void setCurrentDir( final File current_dir ) {\r
+        _current_dir = current_dir;\r
+    }\r
+\r
+    private void setMinNotCollapseConfidenceValue( final double min_not_collapse ) {\r
+        _min_not_collapse = min_not_collapse;\r
+    }\r
+\r
+    private void setPhylogeneticInferenceOptions( final PhylogeneticInferenceOptions phylogenetic_inference_options ) {\r
+        _phylogenetic_inference_options = phylogenetic_inference_options;\r
+    }\r
+\r
+    private void setSpecialOptionsForNexParser( final NexusPhylogeniesParser nex ) {\r
+        nex.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
+        nex.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
+    }\r
+\r
+    private void setSpecialOptionsForNhxParser( final NHXParser nhx ) {\r
+        nhx.setReplaceUnderscores( getOptions().isReplaceUnderscoresInNhParsing() );\r
+        nhx.setTaxonomyExtraction( getOptions().getTaxonomyExtraction() );\r
+        nhx.setAllowErrorsInDistanceToParent( getOptions().isAllowErrorsInDistanceToParent() );\r
+    }\r
+\r
+    private void writeAllToFile() {\r
+        if ( ( getMainPanel().getTabbedPane() == null ) || ( getMainPanel().getTabbedPane().getTabCount() < 1 ) ) {\r
+            return;\r
+        }\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _save_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        _save_filechooser.setSelectedFile( new File( "" ) );\r
+        final int result = _save_filechooser.showSaveDialog( _contentpane );\r
+        final File file = _save_filechooser.getSelectedFile();\r
+        setCurrentDir( _save_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( file.exists() ) {\r
+                final int i = JOptionPane.showConfirmDialog( this,\r
+                                                             file + " already exists. Overwrite?",\r
+                                                             "Warning",\r
+                                                             JOptionPane.OK_CANCEL_OPTION,\r
+                                                             JOptionPane.WARNING_MESSAGE );\r
+                if ( i != JOptionPane.OK_OPTION ) {\r
+                    return;\r
+                }\r
+                else {\r
+                    try {\r
+                        file.delete();\r
+                    }\r
+                    catch ( final Exception e ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Failed to delete: " + file,\r
+                                                       "Error",\r
+                                                       JOptionPane.WARNING_MESSAGE );\r
+                    }\r
+                }\r
+            }\r
+            final int count = getMainPanel().getTabbedPane().getTabCount();\r
+            final List<Phylogeny> trees = new ArrayList<Phylogeny>();\r
+            for( int i = 0; i < count; ++i ) {\r
+                final Phylogeny phy = getMainPanel().getPhylogeny( i );\r
+                if ( ForesterUtil.isEmpty( phy.getName() )\r
+                        && !ForesterUtil.isEmpty( getMainPanel().getTabbedPane().getTitleAt( i ) ) ) {\r
+                    phy.setName( getMainPanel().getTabbedPane().getTitleAt( i ) );\r
+                }\r
+                trees.add( phy );\r
+                getMainPanel().getTreePanels().get( i ).setEdited( false );\r
+            }\r
+            final PhylogenyWriter writer = new PhylogenyWriter();\r
+            try {\r
+                writer.toPhyloXML( file, trees, 0, ForesterUtil.LINE_SEPARATOR );\r
+            }\r
+            catch ( final IOException e ) {\r
+                JOptionPane.showMessageDialog( this,\r
+                                               "Failed to write to: " + file,\r
+                                               "Error",\r
+                                               JOptionPane.WARNING_MESSAGE );\r
+            }\r
+        }\r
+    }\r
+\r
+    private boolean writeAsNewHampshire( final Phylogeny t, boolean exception, final File file ) {\r
+        try {\r
+            final PhylogenyWriter writer = new PhylogenyWriter();\r
+            writer.toNewHampshire( t, true, getOptions().getNhConversionSupportValueStyle(), file );\r
+        }\r
+        catch ( final Exception e ) {\r
+            exception = true;\r
+            exceptionOccuredDuringSaveAs( e );\r
+        }\r
+        return exception;\r
+    }\r
+\r
+    private boolean writeAsNexus( final Phylogeny t, boolean exception, final File file ) {\r
+        try {\r
+            final PhylogenyWriter writer = new PhylogenyWriter();\r
+            writer.toNexus( file, t, getOptions().getNhConversionSupportValueStyle() );\r
+        }\r
+        catch ( final Exception e ) {\r
+            exception = true;\r
+            exceptionOccuredDuringSaveAs( e );\r
+        }\r
+        return exception;\r
+    }\r
+\r
+    private boolean writeAsPhyloXml( final Phylogeny t, boolean exception, final File file ) {\r
+        try {\r
+            final PhylogenyWriter writer = new PhylogenyWriter();\r
+            writer.toPhyloXML( file, t, 0 );\r
+        }\r
+        catch ( final Exception e ) {\r
+            exception = true;\r
+            exceptionOccuredDuringSaveAs( e );\r
+        }\r
+        return exception;\r
+    }\r
+\r
+    private void writeToFile( final Phylogeny t ) {\r
+        if ( t == null ) {\r
+            return;\r
+        }\r
+        String initial_filename = null;\r
+        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
+            try {\r
+                initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().getCanonicalPath();\r
+            }\r
+            catch ( final IOException e ) {\r
+                initial_filename = null;\r
+            }\r
+        }\r
+        if ( !ForesterUtil.isEmpty( initial_filename ) ) {\r
+            _save_filechooser.setSelectedFile( new File( initial_filename ) );\r
+        }\r
+        else {\r
+            _save_filechooser.setSelectedFile( new File( "" ) );\r
+        }\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _save_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _save_filechooser.showSaveDialog( _contentpane );\r
+        final File file = _save_filechooser.getSelectedFile();\r
+        setCurrentDir( _save_filechooser.getCurrentDirectory() );\r
+        boolean exception = false;\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( file.exists() ) {\r
+                final int i = JOptionPane.showConfirmDialog( this,\r
+                                                             file + " already exists.\nOverwrite?",\r
+                                                             "Overwrite?",\r
+                                                             JOptionPane.OK_CANCEL_OPTION,\r
+                                                             JOptionPane.QUESTION_MESSAGE );\r
+                if ( i != JOptionPane.OK_OPTION ) {\r
+                    return;\r
+                }\r
+                else {\r
+                    final File to = new File( file.getAbsoluteFile().toString() + Constants.BACKUP_FILE_SUFFIX );\r
+                    try {\r
+                        ForesterUtil.copyFile( file, to );\r
+                    }\r
+                    catch ( final Exception e ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Failed to create backup copy " + to,\r
+                                                       "Failed to Create Backup Copy",\r
+                                                       JOptionPane.WARNING_MESSAGE );\r
+                    }\r
+                    try {\r
+                        file.delete();\r
+                    }\r
+                    catch ( final Exception e ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Failed to delete: " + file,\r
+                                                       "Failed to Delete",\r
+                                                       JOptionPane.WARNING_MESSAGE );\r
+                    }\r
+                }\r
+            }\r
+            if ( _save_filechooser.getFileFilter() == MainFrameApplication.nhfilter ) {\r
+                exception = writeAsNewHampshire( t, exception, file );\r
+            }\r
+            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.xmlfilter ) {\r
+                exception = writeAsPhyloXml( t, exception, file );\r
+            }\r
+            else if ( _save_filechooser.getFileFilter() == MainFrameApplication.nexusfilter ) {\r
+                exception = writeAsNexus( t, exception, file );\r
+            }\r
+            // "*.*":\r
+            else {\r
+                final String file_name = file.getName().trim().toLowerCase();\r
+                if ( file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
+                        || file_name.endsWith( ".tree" ) ) {\r
+                    exception = writeAsNewHampshire( t, exception, file );\r
+                }\r
+                else if ( file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) ) {\r
+                    exception = writeAsNexus( t, exception, file );\r
+                }\r
+                // XML is default:\r
+                else {\r
+                    exception = writeAsPhyloXml( t, exception, file );\r
+                }\r
+            }\r
+            if ( !exception ) {\r
+                getMainPanel().setTitleOfSelectedTab( file.getName() );\r
+                getMainPanel().getCurrentTreePanel().setTreeFile( file );\r
+                getMainPanel().getCurrentTreePanel().setEdited( false );\r
+            }\r
+        }\r
+    }\r
+\r
+    private void writeToGraphicsFile( final Phylogeny t, final GraphicsExportType type ) {\r
+        if ( ( t == null ) || t.isEmpty() ) {\r
+            return;\r
+        }\r
+        String initial_filename = "";\r
+        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
+            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();\r
+        }\r
+        if ( initial_filename.indexOf( '.' ) > 0 ) {\r
+            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );\r
+        }\r
+        initial_filename = initial_filename + "." + type;\r
+        _writetographics_filechooser.setSelectedFile( new File( initial_filename ) );\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _writetographics_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _writetographics_filechooser.showSaveDialog( _contentpane );\r
+        File file = _writetographics_filechooser.getSelectedFile();\r
+        setCurrentDir( _writetographics_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( !file.toString().toLowerCase().endsWith( type.toString() ) ) {\r
+                file = new File( file.toString() + "." + type );\r
+            }\r
+            if ( file.exists() ) {\r
+                final int i = JOptionPane.showConfirmDialog( this,\r
+                                                             file + " already exists. Overwrite?",\r
+                                                             "Warning",\r
+                                                             JOptionPane.OK_CANCEL_OPTION,\r
+                                                             JOptionPane.WARNING_MESSAGE );\r
+                if ( i != JOptionPane.OK_OPTION ) {\r
+                    return;\r
+                }\r
+                else {\r
+                    try {\r
+                        file.delete();\r
+                    }\r
+                    catch ( final Exception e ) {\r
+                        JOptionPane.showMessageDialog( this,\r
+                                                       "Failed to delete: " + file,\r
+                                                       "Error",\r
+                                                       JOptionPane.WARNING_MESSAGE );\r
+                    }\r
+                }\r
+            }\r
+            writePhylogenyToGraphicsFile( file.toString(), type );\r
+        }\r
+    }\r
+\r
+    private void writeToPdf( final Phylogeny t ) {\r
+        if ( ( t == null ) || t.isEmpty() ) {\r
+            return;\r
+        }\r
+        String initial_filename = "";\r
+        if ( getMainPanel().getCurrentTreePanel().getTreeFile() != null ) {\r
+            initial_filename = getMainPanel().getCurrentTreePanel().getTreeFile().toString();\r
+        }\r
+        if ( initial_filename.indexOf( '.' ) > 0 ) {\r
+            initial_filename = initial_filename.substring( 0, initial_filename.lastIndexOf( '.' ) );\r
+        }\r
+        initial_filename = initial_filename + ".pdf";\r
+        _writetopdf_filechooser.setSelectedFile( new File( initial_filename ) );\r
+        final File my_dir = getCurrentDir();\r
+        if ( my_dir != null ) {\r
+            _writetopdf_filechooser.setCurrentDirectory( my_dir );\r
+        }\r
+        final int result = _writetopdf_filechooser.showSaveDialog( _contentpane );\r
+        File file = _writetopdf_filechooser.getSelectedFile();\r
+        setCurrentDir( _writetopdf_filechooser.getCurrentDirectory() );\r
+        if ( ( file != null ) && ( result == JFileChooser.APPROVE_OPTION ) ) {\r
+            if ( !file.toString().toLowerCase().endsWith( ".pdf" ) ) {\r
+                file = new File( file.toString() + ".pdf" );\r
+            }\r
+            if ( file.exists() ) {\r
+                final int i = JOptionPane.showConfirmDialog( this,\r
+                                                             file + " already exists. Overwrite?",\r
+                                                             "WARNING",\r
+                                                             JOptionPane.OK_CANCEL_OPTION,\r
+                                                             JOptionPane.WARNING_MESSAGE );\r
+                if ( i != JOptionPane.OK_OPTION ) {\r
+                    return;\r
+                }\r
+            }\r
+            printPhylogenyToPdf( file.toString() );\r
+        }\r
+    }\r
+\r
+    public static MainFrameApplication createInstance( final Phylogeny[] phys, final Configuration config ) {\r
+        return new MainFrameApplication( phys, config );\r
+    }\r
+\r
+    public static MainFrame createInstance( final Phylogeny[] phys,\r
+                                            final Configuration config,\r
+                                            final String title,\r
+                                            final File current_dir ) {\r
+        return new MainFrameApplication( phys, config, title, current_dir );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final Configuration config, final String title ) {\r
+        return new MainFrameApplication( phys, config, title );\r
+    }\r
+\r
+    static MainFrame createInstance( final Phylogeny[] phys, final String config_file_name, final String title ) {\r
+        return new MainFrameApplication( phys, config_file_name, title );\r
+    }\r
+\r
+    static void setTextForGraphicsSizeChooserMenuItem( final JMenuItem mi, final Options o ) {\r
+        mi.setText( "Enter Default Size for Graphics Export... (current: " + o.getPrintSizeX() + ", "\r
+                + o.getPrintSizeY() + ")" );\r
+    }\r
+\r
+    static void setTextForPdfLineWidthChooserMenuItem( final JMenuItem mi, final Options o ) {\r
+        mi.setText( "Enter Default Line Width for PDF Export... (current: " + o.getPrintLineWidth() + ")" );\r
+    }\r
+\r
+    static void warnIfNotPhyloXmlValidation( final Configuration c ) {\r
+        if ( !c.isValidatePhyloXmlAgainstSchema() ) {\r
+            JOptionPane\r
+                    .showMessageDialog( null,\r
+                                        ForesterUtil\r
+                                                .wordWrap( "phyloXML XSD-based validation is turned off [enable with line 'validate_against_phyloxml_xsd_schem: true' in configuration file]",\r
+                                                           80 ),\r
+                                        "Warning",\r
+                                        JOptionPane.WARNING_MESSAGE );\r
+        }\r
+    }\r
+} // MainFrameApplication.\r
+\r
+class DefaultFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
+                || file_name.endsWith( ".nwk" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".ph" )\r
+                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".dnd" ) || file_name.endsWith( ".tree" )\r
+                || file_name.endsWith( ".nhx" ) || file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" )\r
+                || file_name.endsWith( "phylo.xml" ) || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".nexus" )\r
+                || file_name.endsWith( ".nx" ) || file_name.endsWith( ".nex" ) || file_name.endsWith( ".tre" )\r
+                || file_name.endsWith( ".zip" ) || file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" )\r
+                || file_name.endsWith( ".con" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "All supported files (*.xml, *.phyloxml, *phylo.xml, *.nhx, *.nh, *.newick, *.nex, *.nexus, *.phy, *.tre, *.tree, *.tol, ...)";\r
+    }\r
+}\r
+\r
+class GraphicsFileFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".jpg" ) || file_name.endsWith( ".jpeg" ) || file_name.endsWith( ".png" )\r
+                || file_name.endsWith( ".gif" ) || file_name.endsWith( ".bmp" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "Image files (*.jpg, *.jpeg, *.png, *.gif, *.bmp)";\r
+    }\r
+}\r
+\r
+class MsaFileFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".msa" ) || file_name.endsWith( ".aln" ) || file_name.endsWith( ".fasta" )\r
+                || file_name.endsWith( ".fas" ) || file_name.endsWith( ".fa" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "Multiple sequence alignment files (*.msa, *.aln, *.fasta, *.fa, *.fas)";\r
+    }\r
+}\r
+\r
+class NexusFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".nex" ) || file_name.endsWith( ".nexus" ) || file_name.endsWith( ".nx" )\r
+                || file_name.endsWith( ".tre" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "Nexus files (*.nex, *.nexus, *.nx, *.tre)";\r
+    }\r
+} // NexusFilter\r
+\r
+class NHFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".nh" ) || file_name.endsWith( ".newick" ) || file_name.endsWith( ".phy" )\r
+                || file_name.endsWith( ".tr" ) || file_name.endsWith( ".tree" ) || file_name.endsWith( ".dnd" )\r
+                || file_name.endsWith( ".ph" ) || file_name.endsWith( ".phb" ) || file_name.endsWith( ".nwk" )\r
+                || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "New Hampshire - Newick files (*.nh, *.newick, *.phy, *.tree, *.dnd, *.tr, *.ph, *.phb, *.nwk)";\r
+    }\r
+} // NHFilter\r
+\r
+class NHXFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".nhx" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "NHX files (*.nhx) [deprecated]";\r
+    }\r
+}\r
+\r
+class PdfFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        return f.getName().trim().toLowerCase().endsWith( ".pdf" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "PDF files (*.pdf)";\r
+    }\r
+} // PdfFilter\r
+\r
+class SequencesFileFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".fasta" ) || file_name.endsWith( ".fa" ) || file_name.endsWith( ".fas" )\r
+                || file_name.endsWith( ".seqs" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "Sequences files (*.fasta, *.fa, *.fas, *.seqs )";\r
+    }\r
+}\r
+\r
+class TolFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return ( file_name.endsWith( ".tol" ) || file_name.endsWith( ".tolxml" ) || file_name.endsWith( ".zip" ) || f\r
+                .isDirectory() ) && ( !file_name.endsWith( ".xml.zip" ) );\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "Tree of Life files (*.tol, *.tolxml)";\r
+    }\r
+} // TolFilter\r
+\r
+class XMLFilter extends FileFilter {\r
+\r
+    @Override\r
+    public boolean accept( final File f ) {\r
+        final String file_name = f.getName().trim().toLowerCase();\r
+        return file_name.endsWith( ".xml" ) || file_name.endsWith( ".phyloxml" ) || file_name.endsWith( "phylo.xml" )\r
+                || file_name.endsWith( ".pxml" ) || file_name.endsWith( ".zip" ) || f.isDirectory();\r
+    }\r
+\r
+    @Override\r
+    public String getDescription() {\r
+        return "phyloXML files (*.xml, *.phyloxml, *phylo.xml, *.pxml, *.zip)";\r
+    }\r
+} // XMLFilter\r
index 01c84c3..5ffa89c 100644 (file)
-// $Id:
-// FORESTER -- software libraries and applications
-// for evolutionary biology research and applications.
-//
-// Copyright (C) 2008-2009 Christian M. Zmasek
-// Copyright (C) 2008-2009 Burnham Institute for Medical Research
-// All rights reserved
-//
-// This library is free software; you can redistribute it and/or
-// modify it under the terms of the GNU Lesser General Public
-// License as published by the Free Software Foundation; either
-// version 2.1 of the License, or (at your option) any later version.
-//
-// This library is distributed in the hope that it will be useful,
-// but WITHOUT ANY WARRANTY; without even the implied warranty of
-// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU
-// Lesser General Public License for more details.
-//
-// You should have received a copy of the GNU Lesser General Public
-// License along with this library; if not, write to the Free Software
-// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA
-//
-// Contact: phylosoft @ gmail . com
-// WWW: https://sites.google.com/site/cmzmasek/home/software/forester
-
-package org.forester.phylogeny;
-
-import java.awt.Color;
-import java.io.File;
-import java.io.IOException;
-import java.util.ArrayList;
-import java.util.Arrays;
-import java.util.Collections;
-import java.util.Comparator;
-import java.util.HashMap;
-import java.util.HashSet;
-import java.util.Iterator;
-import java.util.List;
-import java.util.Map;
-import java.util.Set;
-import java.util.regex.Matcher;
-import java.util.regex.Pattern;
-
-import org.forester.io.parsers.FastaParser;
-import org.forester.io.parsers.PhylogenyParser;
-import org.forester.io.parsers.phyloxml.PhyloXmlDataFormatException;
-import org.forester.io.parsers.phyloxml.PhyloXmlUtil;
-import org.forester.io.parsers.util.PhylogenyParserException;
-import org.forester.phylogeny.data.Accession;
-import org.forester.phylogeny.data.Annotation;
-import org.forester.phylogeny.data.BranchColor;
-import org.forester.phylogeny.data.BranchWidth;
-import org.forester.phylogeny.data.Confidence;
-import org.forester.phylogeny.data.DomainArchitecture;
-import org.forester.phylogeny.data.Event;
-import org.forester.phylogeny.data.Identifier;
-import org.forester.phylogeny.data.PhylogenyDataUtil;
-import org.forester.phylogeny.data.Sequence;
-import org.forester.phylogeny.data.Taxonomy;
-import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;
-import org.forester.phylogeny.factories.PhylogenyFactory;
-import org.forester.phylogeny.iterators.PhylogenyNodeIterator;
-import org.forester.util.BasicDescriptiveStatistics;
-import org.forester.util.DescriptiveStatistics;
-import org.forester.util.ForesterUtil;
-
-public class PhylogenyMethods {
-
-    private PhylogenyMethods() {
-        // Hidden constructor.
-    }
-
-    @Override
-    public Object clone() throws CloneNotSupportedException {
-        throw new CloneNotSupportedException();
-    }
-
-    public static boolean extractFastaInformation( final Phylogeny phy ) {
-        boolean could_extract = false;
-        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            if ( !ForesterUtil.isEmpty( node.getName() ) ) {
-                final Matcher name_m = FastaParser.FASTA_DESC_LINE.matcher( node.getName() );
-                if ( name_m.lookingAt() ) {
-                    could_extract = true;
-                    final String acc_source = name_m.group( 1 );
-                    final String acc = name_m.group( 2 );
-                    final String seq_name = name_m.group( 3 );
-                    final String tax_sn = name_m.group( 4 );
-                    if ( !ForesterUtil.isEmpty( acc_source ) && !ForesterUtil.isEmpty( acc ) ) {
-                        ForesterUtil.ensurePresenceOfSequence( node );
-                        node.getNodeData().getSequence( 0 ).setAccession( new Accession( acc, acc_source ) );
-                    }
-                    if ( !ForesterUtil.isEmpty( seq_name ) ) {
-                        ForesterUtil.ensurePresenceOfSequence( node );
-                        node.getNodeData().getSequence( 0 ).setName( seq_name );
-                    }
-                    if ( !ForesterUtil.isEmpty( tax_sn ) ) {
-                        ForesterUtil.ensurePresenceOfTaxonomy( node );
-                        node.getNodeData().getTaxonomy( 0 ).setScientificName( tax_sn );
-                    }
-                }
-            }
-        }
-        return could_extract;
-    }
-
-    public static DescriptiveStatistics calculatBranchLengthStatistics( final Phylogeny phy ) {
-        final DescriptiveStatistics stats = new BasicDescriptiveStatistics();
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( !n.isRoot() && ( n.getDistanceToParent() >= 0.0 ) ) {
-                stats.addValue( n.getDistanceToParent() );
-            }
-        }
-        return stats;
-    }
-
-    public static List<DescriptiveStatistics> calculatConfidenceStatistics( final Phylogeny phy ) {
-        final List<DescriptiveStatistics> stats = new ArrayList<DescriptiveStatistics>();
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( !n.isExternal() && !n.isRoot() ) {
-                if ( n.getBranchData().isHasConfidences() ) {
-                    for( int i = 0; i < n.getBranchData().getConfidences().size(); ++i ) {
-                        final Confidence c = n.getBranchData().getConfidences().get( i );
-                        if ( ( i > ( stats.size() - 1 ) ) || ( stats.get( i ) == null ) ) {
-                            stats.add( i, new BasicDescriptiveStatistics() );
-                        }
-                        if ( !ForesterUtil.isEmpty( c.getType() ) ) {
-                            if ( !ForesterUtil.isEmpty( stats.get( i ).getDescription() ) ) {
-                                if ( !stats.get( i ).getDescription().equalsIgnoreCase( c.getType() ) ) {
-                                    throw new IllegalArgumentException( "support values in node [" + n.toString()
-                                            + "] appear inconsistently ordered" );
-                                }
-                            }
-                            stats.get( i ).setDescription( c.getType() );
-                        }
-                        stats.get( i ).addValue( ( ( c != null ) && ( c.getValue() >= 0 ) ) ? c.getValue() : 0 );
-                    }
-                }
-            }
-        }
-        return stats;
-    }
-
-    /**
-     * Calculates the distance between PhylogenyNodes node1 and node2.
-     * 
-     * 
-     * @param node1
-     * @param node2
-     * @return distance between node1 and node2
-     */
-    public static double calculateDistance( final PhylogenyNode node1, final PhylogenyNode node2 ) {
-        final PhylogenyNode lca = calculateLCA( node1, node2 );
-        final PhylogenyNode n1 = node1;
-        final PhylogenyNode n2 = node2;
-        return ( PhylogenyMethods.getDistance( n1, lca ) + PhylogenyMethods.getDistance( n2, lca ) );
-    }
-
-    /**
-     * Returns the LCA of PhylogenyNodes node1 and node2.
-     * 
-     * 
-     * @param node1
-     * @param node2
-     * @return LCA of node1 and node2
-     */
-    public final static PhylogenyNode calculateLCA( PhylogenyNode node1, PhylogenyNode node2 ) {
-        if ( node1 == null ) {
-            throw new IllegalArgumentException( "first argument (node) is null" );
-        }
-        if ( node2 == null ) {
-            throw new IllegalArgumentException( "second argument (node) is null" );
-        }
-        if ( node1 == node2 ) {
-            return node1;
-        }
-        if ( ( node1.getParent() == node2.getParent() ) ) {
-            return node1.getParent();
-        }
-        int depth1 = node1.calculateDepth();
-        int depth2 = node2.calculateDepth();
-        while ( ( depth1 > -1 ) && ( depth2 > -1 ) ) {
-            if ( depth1 > depth2 ) {
-                node1 = node1.getParent();
-                depth1--;
-            }
-            else if ( depth2 > depth1 ) {
-                node2 = node2.getParent();
-                depth2--;
-            }
-            else {
-                if ( node1 == node2 ) {
-                    return node1;
-                }
-                node1 = node1.getParent();
-                node2 = node2.getParent();
-                depth1--;
-                depth2--;
-            }
-        }
-        throw new IllegalArgumentException( "illegal attempt to calculate LCA of two nodes which do not share a common root" );
-    }
-
-    /**
-     * Returns the LCA of PhylogenyNodes node1 and node2.
-     * Precondition: ids are in pre-order (or level-order).
-     * 
-     * 
-     * @param node1
-     * @param node2
-     * @return LCA of node1 and node2
-     */
-    public final static PhylogenyNode calculateLCAonTreeWithIdsInPreOrder( PhylogenyNode node1, PhylogenyNode node2 ) {
-        if ( node1 == null ) {
-            throw new IllegalArgumentException( "first argument (node) is null" );
-        }
-        if ( node2 == null ) {
-            throw new IllegalArgumentException( "second argument (node) is null" );
-        }
-        while ( node1 != node2 ) {
-            if ( node1.getId() > node2.getId() ) {
-                node1 = node1.getParent();
-            }
-            else {
-                node2 = node2.getParent();
-            }
-        }
-        return node1;
-    }
-
-    public static short calculateMaxBranchesToLeaf( final PhylogenyNode node ) {
-        if ( node.isExternal() ) {
-            return 0;
-        }
-        short max = 0;
-        for( PhylogenyNode d : node.getAllExternalDescendants() ) {
-            short steps = 0;
-            while ( d != node ) {
-                if ( d.isCollapse() ) {
-                    steps = 0;
-                }
-                else {
-                    steps++;
-                }
-                d = d.getParent();
-            }
-            if ( max < steps ) {
-                max = steps;
-            }
-        }
-        return max;
-    }
-
-    public static int calculateMaxDepth( final Phylogeny phy ) {
-        int max = 0;
-        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            final int steps = node.calculateDepth();
-            if ( steps > max ) {
-                max = steps;
-            }
-        }
-        return max;
-    }
-
-    public static double calculateMaxDistanceToRoot( final Phylogeny phy ) {
-        double max = 0.0;
-        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            final double d = node.calculateDistanceToRoot();
-            if ( d > max ) {
-                max = d;
-            }
-        }
-        return max;
-    }
-
-    public static int calculateNumberOfExternalNodesWithoutTaxonomy( final PhylogenyNode node ) {
-        final List<PhylogenyNode> descs = node.getAllExternalDescendants();
-        int x = 0;
-        for( final PhylogenyNode n : descs ) {
-            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {
-                x++;
-            }
-        }
-        return x;
-    }
-
-    public static DescriptiveStatistics calculatNumberOfDescendantsPerNodeStatistics( final Phylogeny phy ) {
-        final DescriptiveStatistics stats = new BasicDescriptiveStatistics();
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( !n.isExternal() ) {
-                stats.addValue( n.getNumberOfDescendants() );
-            }
-        }
-        return stats;
-    }
-
-    public final static void collapseSubtreeStructure( final PhylogenyNode n ) {
-        final List<PhylogenyNode> eds = n.getAllExternalDescendants();
-        final List<Double> d = new ArrayList<Double>();
-        for( final PhylogenyNode ed : eds ) {
-            d.add( calculateDistanceToAncestor( n, ed ) );
-        }
-        for( int i = 0; i < eds.size(); ++i ) {
-            n.setChildNode( i, eds.get( i ) );
-            eds.get( i ).setDistanceToParent( d.get( i ) );
-        }
-    }
-
-    public static int countNumberOfOneDescendantNodes( final Phylogeny phy ) {
-        int count = 0;
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( !n.isExternal() && ( n.getNumberOfDescendants() == 1 ) ) {
-                count++;
-            }
-        }
-        return count;
-    }
-
-    public static int countNumberOfPolytomies( final Phylogeny phy ) {
-        int count = 0;
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( !n.isExternal() && ( n.getNumberOfDescendants() > 2 ) ) {
-                count++;
-            }
-        }
-        return count;
-    }
-
-    public static final HashMap<String, PhylogenyNode> createNameToExtNodeMap( final Phylogeny phy ) {
-        final HashMap<String, PhylogenyNode> nodes = new HashMap<String, PhylogenyNode>();
-        final List<PhylogenyNode> ext = phy.getExternalNodes();
-        for( final PhylogenyNode n : ext ) {
-            nodes.put( n.getName(), n );
-        }
-        return nodes;
-    }
-
-    public static void deleteExternalNodesNegativeSelection( final Set<Long> to_delete, final Phylogeny phy ) {
-        for( final Long id : to_delete ) {
-            phy.deleteSubtree( phy.getNode( id ), true );
-        }
-        phy.clearHashIdToNodeMap();
-        phy.externalNodesHaveChanged();
-    }
-
-    public static void deleteExternalNodesNegativeSelection( final String[] node_names_to_delete, final Phylogeny p )
-            throws IllegalArgumentException {
-        for( final String element : node_names_to_delete ) {
-            if ( ForesterUtil.isEmpty( element ) ) {
-                continue;
-            }
-            List<PhylogenyNode> nodes = null;
-            nodes = p.getNodes( element );
-            final Iterator<PhylogenyNode> it = nodes.iterator();
-            while ( it.hasNext() ) {
-                final PhylogenyNode n = it.next();
-                if ( !n.isExternal() ) {
-                    throw new IllegalArgumentException( "attempt to delete non-external node \"" + element + "\"" );
-                }
-                p.deleteSubtree( n, true );
-            }
-        }
-        p.clearHashIdToNodeMap();
-        p.externalNodesHaveChanged();
-    }
-
-    public static List<String> deleteExternalNodesPositiveSelection( final String[] node_names_to_keep,
-                                                                     final Phylogeny p ) {
-        final PhylogenyNodeIterator it = p.iteratorExternalForward();
-        final String[] to_delete = new String[ p.getNumberOfExternalNodes() ];
-        int i = 0;
-        Arrays.sort( node_names_to_keep );
-        while ( it.hasNext() ) {
-            final String curent_name = it.next().getName();
-            if ( Arrays.binarySearch( node_names_to_keep, curent_name ) < 0 ) {
-                to_delete[ i++ ] = curent_name;
-            }
-        }
-        PhylogenyMethods.deleteExternalNodesNegativeSelection( to_delete, p );
-        final List<String> deleted = new ArrayList<String>();
-        for( final String n : to_delete ) {
-            if ( !ForesterUtil.isEmpty( n ) ) {
-                deleted.add( n );
-            }
-        }
-        return deleted;
-    }
-
-    public static void deleteExternalNodesPositiveSelectionT( final List<Taxonomy> species_to_keep, final Phylogeny phy ) {
-        final Set<Long> to_delete = new HashSet<Long>();
-        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {
-            final PhylogenyNode n = it.next();
-            if ( n.getNodeData().isHasTaxonomy() ) {
-                if ( !species_to_keep.contains( n.getNodeData().getTaxonomy() ) ) {
-                    to_delete.add( n.getId() );
-                }
-            }
-            else {
-                throw new IllegalArgumentException( "node " + n.getId() + " has no taxonomic data" );
-            }
-        }
-        deleteExternalNodesNegativeSelection( to_delete, phy );
-    }
-
-    final public static void deleteInternalNodesWithOnlyOneDescendent( final Phylogeny phy ) {
-        final ArrayList<PhylogenyNode> to_delete = new ArrayList<PhylogenyNode>();
-        for( final PhylogenyNodeIterator iter = phy.iteratorPostorder(); iter.hasNext(); ) {
-            final PhylogenyNode n = iter.next();
-            if ( ( !n.isExternal() ) && ( n.getNumberOfDescendants() == 1 ) ) {
-                to_delete.add( n );
-            }
-        }
-        for( final PhylogenyNode d : to_delete ) {
-            PhylogenyMethods.removeNode( d, phy );
-        }
-        phy.clearHashIdToNodeMap();
-        phy.externalNodesHaveChanged();
-    }
-
-    final public static void deleteNonOrthologousExternalNodes( final Phylogeny phy, final PhylogenyNode n ) {
-        if ( n.isInternal() ) {
-            throw new IllegalArgumentException( "node is not external" );
-        }
-        final ArrayList<PhylogenyNode> to_delete = new ArrayList<PhylogenyNode>();
-        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {
-            final PhylogenyNode i = it.next();
-            if ( !PhylogenyMethods.getEventAtLCA( n, i ).isSpeciation() ) {
-                to_delete.add( i );
-            }
-        }
-        for( final PhylogenyNode d : to_delete ) {
-            phy.deleteSubtree( d, true );
-        }
-        phy.clearHashIdToNodeMap();
-        phy.externalNodesHaveChanged();
-    }
-
-    public final static List<List<PhylogenyNode>> divideIntoSubTrees( final Phylogeny phy,
-                                                                      final double min_distance_to_root ) {
-        if ( min_distance_to_root <= 0 ) {
-            throw new IllegalArgumentException( "attempt to use min distance to root of: " + min_distance_to_root );
-        }
-        final List<List<PhylogenyNode>> l = new ArrayList<List<PhylogenyNode>>();
-        setAllIndicatorsToZero( phy );
-        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {
-            final PhylogenyNode n = it.next();
-            if ( n.getIndicator() != 0 ) {
-                continue;
-            }
-            l.add( divideIntoSubTreesHelper( n, min_distance_to_root ) );
-            if ( l.isEmpty() ) {
-                throw new RuntimeException( "this should not have happened" );
-            }
-        }
-        return l;
-    }
-
-    public static List<PhylogenyNode> getAllDescendants( final PhylogenyNode node ) {
-        final List<PhylogenyNode> descs = new ArrayList<PhylogenyNode>();
-        final Set<Long> encountered = new HashSet<Long>();
-        if ( !node.isExternal() ) {
-            final List<PhylogenyNode> exts = node.getAllExternalDescendants();
-            for( PhylogenyNode current : exts ) {
-                descs.add( current );
-                while ( current != node ) {
-                    current = current.getParent();
-                    if ( encountered.contains( current.getId() ) ) {
-                        continue;
-                    }
-                    descs.add( current );
-                    encountered.add( current.getId() );
-                }
-            }
-        }
-        return descs;
-    }
-
-    /**
-     * 
-     * Convenience method
-     * 
-     * @param node
-     * @return
-     */
-    public static Color getBranchColorValue( final PhylogenyNode node ) {
-        if ( node.getBranchData().getBranchColor() == null ) {
-            return null;
-        }
-        return node.getBranchData().getBranchColor().getValue();
-    }
-
-    /**
-     * Convenience method
-     */
-    public static double getBranchWidthValue( final PhylogenyNode node ) {
-        if ( !node.getBranchData().isHasBranchWidth() ) {
-            return BranchWidth.BRANCH_WIDTH_DEFAULT_VALUE;
-        }
-        return node.getBranchData().getBranchWidth().getValue();
-    }
-
-    /**
-     * Convenience method
-     */
-    public static double getConfidenceValue( final PhylogenyNode node ) {
-        if ( !node.getBranchData().isHasConfidences() ) {
-            return Confidence.CONFIDENCE_DEFAULT_VALUE;
-        }
-        return node.getBranchData().getConfidence( 0 ).getValue();
-    }
-
-    /**
-     * Convenience method
-     */
-    public static double[] getConfidenceValuesAsArray( final PhylogenyNode node ) {
-        if ( !node.getBranchData().isHasConfidences() ) {
-            return new double[ 0 ];
-        }
-        final double[] values = new double[ node.getBranchData().getConfidences().size() ];
-        int i = 0;
-        for( final Confidence c : node.getBranchData().getConfidences() ) {
-            values[ i++ ] = c.getValue();
-        }
-        return values;
-    }
-
-    final public static Event getEventAtLCA( final PhylogenyNode n1, final PhylogenyNode n2 ) {
-        return calculateLCA( n1, n2 ).getNodeData().getEvent();
-    }
-
-    /**
-     * Returns taxonomy t if all external descendants have 
-     * the same taxonomy t, null otherwise.
-     * 
-     */
-    public static Taxonomy getExternalDescendantsTaxonomy( final PhylogenyNode node ) {
-        final List<PhylogenyNode> descs = node.getAllExternalDescendants();
-        Taxonomy tax = null;
-        for( final PhylogenyNode n : descs ) {
-            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {
-                return null;
-            }
-            else if ( tax == null ) {
-                tax = n.getNodeData().getTaxonomy();
-            }
-            else if ( n.getNodeData().getTaxonomy().isEmpty() || !tax.isEqual( n.getNodeData().getTaxonomy() ) ) {
-                return null;
-            }
-        }
-        return tax;
-    }
-
-    public static PhylogenyNode getFurthestDescendant( final PhylogenyNode node ) {
-        final List<PhylogenyNode> children = node.getAllExternalDescendants();
-        PhylogenyNode farthest = null;
-        double longest = -Double.MAX_VALUE;
-        for( final PhylogenyNode child : children ) {
-            if ( PhylogenyMethods.getDistance( child, node ) > longest ) {
-                farthest = child;
-                longest = PhylogenyMethods.getDistance( child, node );
-            }
-        }
-        return farthest;
-    }
-
-    // public static PhylogenyMethods getInstance() {
-    //     if ( PhylogenyMethods._instance == null ) {
-    //         PhylogenyMethods._instance = new PhylogenyMethods();
-    //    }
-    //    return PhylogenyMethods._instance;
-    //  }
-    /**
-     * Returns the largest confidence value found on phy.
-     */
-    static public double getMaximumConfidenceValue( final Phylogeny phy ) {
-        double max = -Double.MAX_VALUE;
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final double s = PhylogenyMethods.getConfidenceValue( iter.next() );
-            if ( ( s != Confidence.CONFIDENCE_DEFAULT_VALUE ) && ( s > max ) ) {
-                max = s;
-            }
-        }
-        return max;
-    }
-
-    static public int getMinimumDescendentsPerInternalNodes( final Phylogeny phy ) {
-        int min = Integer.MAX_VALUE;
-        int d = 0;
-        PhylogenyNode n;
-        for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {
-            n = it.next();
-            if ( n.isInternal() ) {
-                d = n.getNumberOfDescendants();
-                if ( d < min ) {
-                    min = d;
-                }
-            }
-        }
-        return min;
-    }
-
-    /**
-     * Convenience method for display purposes.
-     * Not intended for algorithms.
-     */
-    public static String getSpecies( final PhylogenyNode node ) {
-        if ( !node.getNodeData().isHasTaxonomy() ) {
-            return "";
-        }
-        else if ( !ForesterUtil.isEmpty( node.getNodeData().getTaxonomy().getScientificName() ) ) {
-            return node.getNodeData().getTaxonomy().getScientificName();
-        }
-        if ( !ForesterUtil.isEmpty( node.getNodeData().getTaxonomy().getTaxonomyCode() ) ) {
-            return node.getNodeData().getTaxonomy().getTaxonomyCode();
-        }
-        else {
-            return node.getNodeData().getTaxonomy().getCommonName();
-        }
-    }
-
-    /**
-     * Convenience method for display purposes.
-     * Not intended for algorithms.
-     */
-    public static String getTaxonomyIdentifier( final PhylogenyNode node ) {
-        if ( !node.getNodeData().isHasTaxonomy() || ( node.getNodeData().getTaxonomy().getIdentifier() == null ) ) {
-            return "";
-        }
-        return node.getNodeData().getTaxonomy().getIdentifier().getValue();
-    }
-
-    public final static boolean isAllDecendentsAreDuplications( final PhylogenyNode n ) {
-        if ( n.isExternal() ) {
-            return true;
-        }
-        else {
-            if ( n.isDuplication() ) {
-                for( final PhylogenyNode desc : n.getDescendants() ) {
-                    if ( !isAllDecendentsAreDuplications( desc ) ) {
-                        return false;
-                    }
-                }
-                return true;
-            }
-            else {
-                return false;
-            }
-        }
-    }
-
-    public static boolean isHasExternalDescendant( final PhylogenyNode node ) {
-        for( int i = 0; i < node.getNumberOfDescendants(); ++i ) {
-            if ( node.getChildNode( i ).isExternal() ) {
-                return true;
-            }
-        }
-        return false;
-    }
-
-    /*
-     * This is case insensitive.
-     * 
-     */
-    public synchronized static boolean isTaxonomyHasIdentifierOfGivenProvider( final Taxonomy tax,
-                                                                               final String[] providers ) {
-        if ( ( tax.getIdentifier() != null ) && !ForesterUtil.isEmpty( tax.getIdentifier().getProvider() ) ) {
-            final String my_tax_prov = tax.getIdentifier().getProvider();
-            for( final String provider : providers ) {
-                if ( provider.equalsIgnoreCase( my_tax_prov ) ) {
-                    return true;
-                }
-            }
-            return false;
-        }
-        else {
-            return false;
-        }
-    }
-
-    public static void midpointRoot( final Phylogeny phylogeny ) {
-        if ( ( phylogeny.getNumberOfExternalNodes() < 2 ) || ( calculateMaxDistanceToRoot( phylogeny ) <= 0 ) ) {
-            return;
-        }
-        int counter = 0;
-        final int total_nodes = phylogeny.getNodeCount();
-        while ( true ) {
-            if ( ++counter > total_nodes ) {
-                throw new RuntimeException( "this should not have happened: midpoint rooting does not converge" );
-            }
-            PhylogenyNode a = null;
-            double da = 0;
-            double db = 0;
-            for( int i = 0; i < phylogeny.getRoot().getNumberOfDescendants(); ++i ) {
-                final PhylogenyNode f = getFurthestDescendant( phylogeny.getRoot().getChildNode( i ) );
-                final double df = getDistance( f, phylogeny.getRoot() );
-                if ( df > 0 ) {
-                    if ( df > da ) {
-                        db = da;
-                        da = df;
-                        a = f;
-                    }
-                    else if ( df > db ) {
-                        db = df;
-                    }
-                }
-            }
-            final double diff = da - db;
-            if ( diff < 0.000001 ) {
-                break;
-            }
-            double x = da - ( diff / 2.0 );
-            while ( ( x > a.getDistanceToParent() ) && !a.isRoot() ) {
-                x -= ( a.getDistanceToParent() > 0 ? a.getDistanceToParent() : 0 );
-                a = a.getParent();
-            }
-            phylogeny.reRoot( a, x );
-        }
-        phylogeny.recalculateNumberOfExternalDescendants( true );
-    }
-
-    public static void normalizeBootstrapValues( final Phylogeny phylogeny,
-                                                 final double max_bootstrap_value,
-                                                 final double max_normalized_value ) {
-        for( final PhylogenyNodeIterator iter = phylogeny.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            if ( node.isInternal() ) {
-                final double confidence = getConfidenceValue( node );
-                if ( confidence != Confidence.CONFIDENCE_DEFAULT_VALUE ) {
-                    if ( confidence >= max_bootstrap_value ) {
-                        setBootstrapConfidence( node, max_normalized_value );
-                    }
-                    else {
-                        setBootstrapConfidence( node, ( confidence * max_normalized_value ) / max_bootstrap_value );
-                    }
-                }
-            }
-        }
-    }
-
-    public static List<PhylogenyNode> obtainAllNodesAsList( final Phylogeny phy ) {
-        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();
-        if ( phy.isEmpty() ) {
-            return nodes;
-        }
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            nodes.add( iter.next() );
-        }
-        return nodes;
-    }
-
-    /**
-     * Returns a map of distinct taxonomies of
-     * all external nodes of node.
-     * If at least one of the external nodes has no taxonomy,
-     * null is returned.
-     * 
-     */
-    public static Map<Taxonomy, Integer> obtainDistinctTaxonomyCounts( final PhylogenyNode node ) {
-        final List<PhylogenyNode> descs = node.getAllExternalDescendants();
-        final Map<Taxonomy, Integer> tax_map = new HashMap<Taxonomy, Integer>();
-        for( final PhylogenyNode n : descs ) {
-            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {
-                return null;
-            }
-            final Taxonomy t = n.getNodeData().getTaxonomy();
-            if ( tax_map.containsKey( t ) ) {
-                tax_map.put( t, tax_map.get( t ) + 1 );
-            }
-            else {
-                tax_map.put( t, 1 );
-            }
-        }
-        return tax_map;
-    }
-
-    /**
-     * Arranges the order of childern for each node of this Phylogeny in such a
-     * way that either the branch with more children is on top (right) or on
-     * bottom (left), dependent on the value of boolean order.
-     * 
-     * @param order
-     *            decides in which direction to order
-     * @param pri 
-     */
-    public static void orderAppearance( final PhylogenyNode n,
-                                        final boolean order,
-                                        final boolean order_ext_alphabetically,
-                                        final DESCENDANT_SORT_PRIORITY pri ) {
-        if ( n.isExternal() ) {
-            return;
-        }
-        else {
-            PhylogenyNode temp = null;
-            if ( ( n.getNumberOfDescendants() == 2 )
-                    && ( n.getChildNode1().getNumberOfExternalNodes() != n.getChildNode2().getNumberOfExternalNodes() )
-                    && ( ( n.getChildNode1().getNumberOfExternalNodes() < n.getChildNode2().getNumberOfExternalNodes() ) == order ) ) {
-                temp = n.getChildNode1();
-                n.setChild1( n.getChildNode2() );
-                n.setChild2( temp );
-            }
-            else if ( order_ext_alphabetically ) {
-                boolean all_ext = true;
-                for( final PhylogenyNode i : n.getDescendants() ) {
-                    if ( !i.isExternal() ) {
-                        all_ext = false;
-                        break;
-                    }
-                }
-                if ( all_ext ) {
-                    PhylogenyMethods.sortNodeDescendents( n, pri );
-                }
-            }
-            for( int i = 0; i < n.getNumberOfDescendants(); ++i ) {
-                orderAppearance( n.getChildNode( i ), order, order_ext_alphabetically, pri );
-            }
-        }
-    }
-
-    public static void postorderBranchColorAveragingExternalNodeBased( final Phylogeny p ) {
-        for( final PhylogenyNodeIterator iter = p.iteratorPostorder(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            double red = 0.0;
-            double green = 0.0;
-            double blue = 0.0;
-            int n = 0;
-            if ( node.isInternal() ) {
-                //for( final PhylogenyNodeIterator iterator = node.iterateChildNodesForward(); iterator.hasNext(); ) {
-                for( int i = 0; i < node.getNumberOfDescendants(); ++i ) {
-                    final PhylogenyNode child_node = node.getChildNode( i );
-                    final Color child_color = getBranchColorValue( child_node );
-                    if ( child_color != null ) {
-                        ++n;
-                        red += child_color.getRed();
-                        green += child_color.getGreen();
-                        blue += child_color.getBlue();
-                    }
-                }
-                setBranchColorValue( node,
-                                     new Color( ForesterUtil.roundToInt( red / n ),
-                                                ForesterUtil.roundToInt( green / n ),
-                                                ForesterUtil.roundToInt( blue / n ) ) );
-            }
-        }
-    }
-
-    public static final void preOrderReId( final Phylogeny phy ) {
-        if ( phy.isEmpty() ) {
-            return;
-        }
-        phy.setIdToNodeMap( null );
-        long i = PhylogenyNode.getNodeCount();
-        for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {
-            it.next().setId( i++ );
-        }
-        PhylogenyNode.setNodeCount( i );
-    }
-
-    public final static Phylogeny[] readPhylogenies( final PhylogenyParser parser, final File file ) throws IOException {
-        final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();
-        final Phylogeny[] trees = factory.create( file, parser );
-        if ( ( trees == null ) || ( trees.length == 0 ) ) {
-            throw new PhylogenyParserException( "Unable to parse phylogeny from file: " + file );
-        }
-        return trees;
-    }
-
-    public final static Phylogeny[] readPhylogenies( final PhylogenyParser parser, final List<File> files )
-            throws IOException {
-        final List<Phylogeny> tree_list = new ArrayList<Phylogeny>();
-        for( final File file : files ) {
-            final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();
-            final Phylogeny[] trees = factory.create( file, parser );
-            if ( ( trees == null ) || ( trees.length == 0 ) ) {
-                throw new PhylogenyParserException( "Unable to parse phylogeny from file: " + file );
-            }
-            tree_list.addAll( Arrays.asList( trees ) );
-        }
-        return tree_list.toArray( new Phylogeny[ tree_list.size() ] );
-    }
-
-    public static void removeNode( final PhylogenyNode remove_me, final Phylogeny phylogeny ) {
-        if ( remove_me.isRoot() ) {
-            if ( remove_me.getNumberOfDescendants() == 1 ) {
-                final PhylogenyNode desc = remove_me.getDescendants().get( 0 );
-                desc.setDistanceToParent( addPhylogenyDistances( remove_me.getDistanceToParent(),
-                                                                 desc.getDistanceToParent() ) );
-                desc.setParent( null );
-                phylogeny.setRoot( desc );
-                phylogeny.clearHashIdToNodeMap();
-            }
-            else {
-                throw new IllegalArgumentException( "attempt to remove a root node with more than one descendants" );
-            }
-        }
-        else if ( remove_me.isExternal() ) {
-            phylogeny.deleteSubtree( remove_me, false );
-            phylogeny.clearHashIdToNodeMap();
-            phylogeny.externalNodesHaveChanged();
-        }
-        else {
-            final PhylogenyNode parent = remove_me.getParent();
-            final List<PhylogenyNode> descs = remove_me.getDescendants();
-            parent.removeChildNode( remove_me );
-            for( final PhylogenyNode desc : descs ) {
-                parent.addAsChild( desc );
-                desc.setDistanceToParent( addPhylogenyDistances( remove_me.getDistanceToParent(),
-                                                                 desc.getDistanceToParent() ) );
-            }
-            remove_me.setParent( null );
-            phylogeny.clearHashIdToNodeMap();
-            phylogeny.externalNodesHaveChanged();
-        }
-    }
-
-    public static List<PhylogenyNode> searchData( final String query,
-                                                  final Phylogeny phy,
-                                                  final boolean case_sensitive,
-                                                  final boolean partial,
-                                                  final boolean search_domains ) {
-        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();
-        if ( phy.isEmpty() || ( query == null ) ) {
-            return nodes;
-        }
-        if ( ForesterUtil.isEmpty( query ) ) {
-            return nodes;
-        }
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            boolean match = false;
-            if ( match( node.getName(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            else if ( node.getNodeData().isHasTaxonomy()
-                    && match( node.getNodeData().getTaxonomy().getTaxonomyCode(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            else if ( node.getNodeData().isHasTaxonomy()
-                    && match( node.getNodeData().getTaxonomy().getCommonName(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            else if ( node.getNodeData().isHasTaxonomy()
-                    && match( node.getNodeData().getTaxonomy().getScientificName(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            else if ( node.getNodeData().isHasTaxonomy()
-                    && ( node.getNodeData().getTaxonomy().getIdentifier() != null )
-                    && match( node.getNodeData().getTaxonomy().getIdentifier().getValue(),
-                              query,
-                              case_sensitive,
-                              partial ) ) {
-                match = true;
-            }
-            else if ( node.getNodeData().isHasTaxonomy() && !node.getNodeData().getTaxonomy().getSynonyms().isEmpty() ) {
-                final List<String> syns = node.getNodeData().getTaxonomy().getSynonyms();
-                I: for( final String syn : syns ) {
-                    if ( match( syn, query, case_sensitive, partial ) ) {
-                        match = true;
-                        break I;
-                    }
-                }
-            }
-            if ( !match && node.getNodeData().isHasSequence()
-                    && match( node.getNodeData().getSequence().getName(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            if ( !match && node.getNodeData().isHasSequence()
-                    && match( node.getNodeData().getSequence().getGeneName(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            if ( !match && node.getNodeData().isHasSequence()
-                    && match( node.getNodeData().getSequence().getSymbol(), query, case_sensitive, partial ) ) {
-                match = true;
-            }
-            if ( !match
-                    && node.getNodeData().isHasSequence()
-                    && ( node.getNodeData().getSequence().getAccession() != null )
-                    && match( node.getNodeData().getSequence().getAccession().getValue(),
-                              query,
-                              case_sensitive,
-                              partial ) ) {
-                match = true;
-            }
-            if ( search_domains && !match && node.getNodeData().isHasSequence()
-                    && ( node.getNodeData().getSequence().getDomainArchitecture() != null ) ) {
-                final DomainArchitecture da = node.getNodeData().getSequence().getDomainArchitecture();
-                I: for( int i = 0; i < da.getNumberOfDomains(); ++i ) {
-                    if ( match( da.getDomain( i ).getName(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break I;
-                    }
-                }
-            }
-            //
-            if ( !match && node.getNodeData().isHasSequence()
-                    && ( node.getNodeData().getSequence().getAnnotations() != null ) ) {
-                for( final Annotation ann : node.getNodeData().getSequence().getAnnotations() ) {
-                    if ( match( ann.getDesc(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break;
-                    }
-                    if ( match( ann.getRef(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break;
-                    }
-                }
-            }
-            if ( !match && node.getNodeData().isHasSequence()
-                    && ( node.getNodeData().getSequence().getCrossReferences() != null ) ) {
-                for( final Accession x : node.getNodeData().getSequence().getCrossReferences() ) {
-                    if ( match( x.getComment(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break;
-                    }
-                    if ( match( x.getSource(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break;
-                    }
-                    if ( match( x.getValue(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break;
-                    }
-                }
-            }
-            //
-            if ( !match && ( node.getNodeData().getBinaryCharacters() != null ) ) {
-                Iterator<String> it = node.getNodeData().getBinaryCharacters().getPresentCharacters().iterator();
-                I: while ( it.hasNext() ) {
-                    if ( match( it.next(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break I;
-                    }
-                }
-                it = node.getNodeData().getBinaryCharacters().getGainedCharacters().iterator();
-                I: while ( it.hasNext() ) {
-                    if ( match( it.next(), query, case_sensitive, partial ) ) {
-                        match = true;
-                        break I;
-                    }
-                }
-            }
-            if ( match ) {
-                nodes.add( node );
-            }
-        }
-        return nodes;
-    }
-
-    public static List<PhylogenyNode> searchDataLogicalAnd( final String[] queries,
-                                                            final Phylogeny phy,
-                                                            final boolean case_sensitive,
-                                                            final boolean partial,
-                                                            final boolean search_domains ) {
-        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();
-        if ( phy.isEmpty() || ( queries == null ) || ( queries.length < 1 ) ) {
-            return nodes;
-        }
-        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {
-            final PhylogenyNode node = iter.next();
-            boolean all_matched = true;
-            for( final String query : queries ) {
-                boolean match = false;
-                if ( ForesterUtil.isEmpty( query ) ) {
-                    continue;
-                }
-                if ( match( node.getName(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                else if ( node.getNodeData().isHasTaxonomy()
-                        && match( node.getNodeData().getTaxonomy().getTaxonomyCode(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                else if ( node.getNodeData().isHasTaxonomy()
-                        && match( node.getNodeData().getTaxonomy().getCommonName(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                else if ( node.getNodeData().isHasTaxonomy()
-                        && match( node.getNodeData().getTaxonomy().getScientificName(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                else if ( node.getNodeData().isHasTaxonomy()
-                        && ( node.getNodeData().getTaxonomy().getIdentifier() != null )
-                        && match( node.getNodeData().getTaxonomy().getIdentifier().getValue(),
-                                  query,
-                                  case_sensitive,
-                                  partial ) ) {
-                    match = true;
-                }
-                else if ( node.getNodeData().isHasTaxonomy()
-                        && !node.getNodeData().getTaxonomy().getSynonyms().isEmpty() ) {
-                    final List<String> syns = node.getNodeData().getTaxonomy().getSynonyms();
-                    I: for( final String syn : syns ) {
-                        if ( match( syn, query, case_sensitive, partial ) ) {
-                            match = true;
-                            break I;
-                        }
-                    }
-                }
-                if ( !match && node.getNodeData().isHasSequence()
-                        && match( node.getNodeData().getSequence().getName(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                if ( !match && node.getNodeData().isHasSequence()
-                        && match( node.getNodeData().getSequence().getGeneName(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                if ( !match && node.getNodeData().isHasSequence()
-                        && match( node.getNodeData().getSequence().getSymbol(), query, case_sensitive, partial ) ) {
-                    match = true;
-                }
-                if ( !match
-                        && node.getNodeData().isHasSequence()
-                        && ( node.getNodeData().getSequence().getAccession() != null )
-                        && match( node.getNodeData().getSequence().getAccession().getValue(),
-                                  query,
-                                  case_sensitive,
-                                  partial ) ) {
-                    match = true;
-                }
-                if ( search_domains && !match && node.getNodeData().isHasSequence()
-                        && ( node.getNodeData().getSequence().getDomainArchitecture() != null ) ) {
-                    final DomainArchitecture da = node.getNodeData().getSequence().getDomainArchitecture();
-                    I: for( int i = 0; i < da.getNumberOfDomains(); ++i ) {
-                        if ( match( da.getDomain( i ).getName(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break I;
-                        }
-                    }
-                }
-                //
-                if ( !match && node.getNodeData().isHasSequence()
-                        && ( node.getNodeData().getSequence().getAnnotations() != null ) ) {
-                    for( final Annotation ann : node.getNodeData().getSequence().getAnnotations() ) {
-                        if ( match( ann.getDesc(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break;
-                        }
-                        if ( match( ann.getRef(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break;
-                        }
-                    }
-                }
-                if ( !match && node.getNodeData().isHasSequence()
-                        && ( node.getNodeData().getSequence().getCrossReferences() != null ) ) {
-                    for( final Accession x : node.getNodeData().getSequence().getCrossReferences() ) {
-                        if ( match( x.getComment(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break;
-                        }
-                        if ( match( x.getSource(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break;
-                        }
-                        if ( match( x.getValue(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break;
-                        }
-                    }
-                }
-                //
-                if ( !match && ( node.getNodeData().getBinaryCharacters() != null ) ) {
-                    Iterator<String> it = node.getNodeData().getBinaryCharacters().getPresentCharacters().iterator();
-                    I: while ( it.hasNext() ) {
-                        if ( match( it.next(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break I;
-                        }
-                    }
-                    it = node.getNodeData().getBinaryCharacters().getGainedCharacters().iterator();
-                    I: while ( it.hasNext() ) {
-                        if ( match( it.next(), query, case_sensitive, partial ) ) {
-                            match = true;
-                            break I;
-                        }
-                    }
-                }
-                if ( !match ) {
-                    all_matched = false;
-                    break;
-                }
-            }
-            if ( all_matched ) {
-                nodes.add( node );
-            }
-        }
-        return nodes;
-    }
-
-    public static void setAllIndicatorsToZero( final Phylogeny phy ) {
-        for( final PhylogenyNodeIterator it = phy.iteratorPostorder(); it.hasNext(); ) {
-            it.next().setIndicator( ( byte ) 0 );
-        }
-    }
-
-    /**
-     * Convenience method.
-     * Sets value for the first confidence value (created if not present, values overwritten otherwise). 
-     */
-    public static void setBootstrapConfidence( final PhylogenyNode node, final double bootstrap_confidence_value ) {
-        setConfidence( node, bootstrap_confidence_value, "bootstrap" );
-    }
-
-    public static void setBranchColorValue( final PhylogenyNode node, final Color color ) {
-        if ( node.getBranchData().getBranchColor() == null ) {
-            node.getBranchData().setBranchColor( new BranchColor() );
-        }
-        node.getBranchData().getBranchColor().setValue( color );
-    }
-
-    /**
-     * Convenience method
-     */
-    public static void setBranchWidthValue( final PhylogenyNode node, final double branch_width_value ) {
-        node.getBranchData().setBranchWidth( new BranchWidth( branch_width_value ) );
-    }
-
-    /**
-     * Convenience method.
-     * Sets value for the first confidence value (created if not present, values overwritten otherwise). 
-     */
-    public static void setConfidence( final PhylogenyNode node, final double confidence_value ) {
-        setConfidence( node, confidence_value, "" );
-    }
-
-    /**
-     * Convenience method.
-     * Sets value for the first confidence value (created if not present, values overwritten otherwise). 
-     */
-    public static void setConfidence( final PhylogenyNode node, final double confidence_value, final String type ) {
-        Confidence c = null;
-        if ( node.getBranchData().getNumberOfConfidences() > 0 ) {
-            c = node.getBranchData().getConfidence( 0 );
-        }
-        else {
-            c = new Confidence();
-            node.getBranchData().addConfidence( c );
-        }
-        c.setType( type );
-        c.setValue( confidence_value );
-    }
-
-    public static void setScientificName( final PhylogenyNode node, final String scientific_name ) {
-        if ( !node.getNodeData().isHasTaxonomy() ) {
-            node.getNodeData().setTaxonomy( new Taxonomy() );
-        }
-        node.getNodeData().getTaxonomy().setScientificName( scientific_name );
-    }
-
-    /**
-     * Convenience method to set the taxonomy code of a phylogeny node.
-     * 
-     * 
-     * @param node
-     * @param taxonomy_code
-     * @throws PhyloXmlDataFormatException 
-     */
-    public static void setTaxonomyCode( final PhylogenyNode node, final String taxonomy_code )
-            throws PhyloXmlDataFormatException {
-        if ( !node.getNodeData().isHasTaxonomy() ) {
-            node.getNodeData().setTaxonomy( new Taxonomy() );
-        }
-        node.getNodeData().getTaxonomy().setTaxonomyCode( taxonomy_code );
-    }
-
-    final static public void sortNodeDescendents( final PhylogenyNode node, final DESCENDANT_SORT_PRIORITY pri ) {
-        class PhylogenyNodeSortTaxonomyPriority implements Comparator<PhylogenyNode> {
-
-            @Override
-            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {
-                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()
-                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );
-                    }
-                }
-                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {
-                        return n1.getNodeData().getSequence().getName().toLowerCase()
-                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {
-                        return n1.getNodeData().getSequence().getSymbol()
-                                .compareTo( n2.getNodeData().getSequence().getSymbol() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {
-                        return n1.getNodeData().getSequence().getGeneName()
-                                .compareTo( n2.getNodeData().getSequence().getGeneName() );
-                    }
-                    if ( ( n1.getNodeData().getSequence().getAccession() != null )
-                            && ( n2.getNodeData().getSequence().getAccession() != null )
-                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )
-                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {
-                        return n1.getNodeData().getSequence().getAccession().getValue()
-                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );
-                    }
-                }
-                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {
-                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );
-                }
-                return 0;
-            }
-        }
-        class PhylogenyNodeSortSequencePriority implements Comparator<PhylogenyNode> {
-
-            @Override
-            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {
-                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {
-                        return n1.getNodeData().getSequence().getName().toLowerCase()
-                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {
-                        return n1.getNodeData().getSequence().getSymbol()
-                                .compareTo( n2.getNodeData().getSequence().getSymbol() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {
-                        return n1.getNodeData().getSequence().getGeneName()
-                                .compareTo( n2.getNodeData().getSequence().getGeneName() );
-                    }
-                    if ( ( n1.getNodeData().getSequence().getAccession() != null )
-                            && ( n2.getNodeData().getSequence().getAccession() != null )
-                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )
-                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {
-                        return n1.getNodeData().getSequence().getAccession().getValue()
-                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );
-                    }
-                }
-                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()
-                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );
-                    }
-                }
-                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {
-                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );
-                }
-                return 0;
-            }
-        }
-        class PhylogenyNodeSortNodeNamePriority implements Comparator<PhylogenyNode> {
-
-            @Override
-            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {
-                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {
-                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );
-                }
-                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()
-                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {
-                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()
-                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );
-                    }
-                }
-                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {
-                        return n1.getNodeData().getSequence().getName().toLowerCase()
-                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {
-                        return n1.getNodeData().getSequence().getSymbol()
-                                .compareTo( n2.getNodeData().getSequence().getSymbol() );
-                    }
-                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )
-                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {
-                        return n1.getNodeData().getSequence().getGeneName()
-                                .compareTo( n2.getNodeData().getSequence().getGeneName() );
-                    }
-                    if ( ( n1.getNodeData().getSequence().getAccession() != null )
-                            && ( n2.getNodeData().getSequence().getAccession() != null )
-                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )
-                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {
-                        return n1.getNodeData().getSequence().getAccession().getValue()
-                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );
-                    }
-                }
-                return 0;
-            }
-        }
-        Comparator<PhylogenyNode> c;
-        switch ( pri ) {
-            case SEQUENCE:
-                c = new PhylogenyNodeSortSequencePriority();
-                break;
-            case NODE_NAME:
-                c = new PhylogenyNodeSortNodeNamePriority();
-                break;
-            default:
-                c = new PhylogenyNodeSortTaxonomyPriority();
-        }
-        final List<PhylogenyNode> descs = node.getDescendants();
-        Collections.sort( descs, c );
-        int i = 0;
-        for( final PhylogenyNode desc : descs ) {
-            node.setChildNode( i++, desc );
-        }
-    }
-
-    /**
-     * Removes from Phylogeny to_be_stripped all external Nodes which are
-     * associated with a species NOT found in Phylogeny reference.
-     * 
-     * @param reference
-     *            a reference Phylogeny
-     * @param to_be_stripped
-     *            Phylogeny to be stripped
-     * @return nodes removed from to_be_stripped
-     */
-    public static List<PhylogenyNode> taxonomyBasedDeletionOfExternalNodes( final Phylogeny reference,
-                                                                            final Phylogeny to_be_stripped ) {
-        final Set<String> ref_ext_taxo = new HashSet<String>();
-        for( final PhylogenyNodeIterator it = reference.iteratorExternalForward(); it.hasNext(); ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.getNodeData().isHasTaxonomy() ) {
-                throw new IllegalArgumentException( "no taxonomic data in node: " + n );
-            }
-            if ( !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getScientificName() ) ) {
-                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getScientificName() );
-            }
-            if ( !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getTaxonomyCode() ) ) {
-                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getTaxonomyCode() );
-            }
-            if ( ( n.getNodeData().getTaxonomy().getIdentifier() != null )
-                    && !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getIdentifier().getValue() ) ) {
-                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getIdentifier().getValuePlusProvider() );
-            }
-        }
-        final ArrayList<PhylogenyNode> nodes_to_delete = new ArrayList<PhylogenyNode>();
-        for( final PhylogenyNodeIterator it = to_be_stripped.iteratorExternalForward(); it.hasNext(); ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.getNodeData().isHasTaxonomy() ) {
-                nodes_to_delete.add( n );
-            }
-            else if ( !( ref_ext_taxo.contains( n.getNodeData().getTaxonomy().getScientificName() ) )
-                    && !( ref_ext_taxo.contains( n.getNodeData().getTaxonomy().getTaxonomyCode() ) )
-                    && !( ( n.getNodeData().getTaxonomy().getIdentifier() != null ) && ref_ext_taxo.contains( n
-                            .getNodeData().getTaxonomy().getIdentifier().getValuePlusProvider() ) ) ) {
-                nodes_to_delete.add( n );
-            }
-        }
-        for( final PhylogenyNode n : nodes_to_delete ) {
-            to_be_stripped.deleteSubtree( n, true );
-        }
-        to_be_stripped.clearHashIdToNodeMap();
-        to_be_stripped.externalNodesHaveChanged();
-        return nodes_to_delete;
-    }
-
-    final static public void transferInternalNamesToBootstrapSupport( final Phylogeny phy ) {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        while ( it.hasNext() ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.isExternal() && !ForesterUtil.isEmpty( n.getName() ) ) {
-                double value = -1;
-                try {
-                    value = Double.parseDouble( n.getName() );
-                }
-                catch ( final NumberFormatException e ) {
-                    throw new IllegalArgumentException( "failed to parse number from [" + n.getName() + "]: "
-                            + e.getLocalizedMessage() );
-                }
-                if ( value >= 0.0 ) {
-                    n.getBranchData().addConfidence( new Confidence( value, "bootstrap" ) );
-                    n.setName( "" );
-                }
-            }
-        }
-    }
-
-    final static public boolean isInternalNamesLookLikeConfidences( final Phylogeny phy ) {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        while ( it.hasNext() ) {
-            final PhylogenyNode n = it.next();
-            if ( !n.isExternal() && !n.isRoot() ) {
-                if ( !ForesterUtil.isEmpty( n.getName() ) ) {
-                    double value = -1;
-                    try {
-                        value = Double.parseDouble( n.getName() );
-                    }
-                    catch ( final NumberFormatException e ) {
-                        return false;
-                    }
-                    if ( ( value < 0.0 ) || ( value > 100 ) ) {
-                        return false;
-                    }
-                }
-            }
-        }
-        return true;
-    }
-
-    final static public void transferInternalNodeNamesToConfidence( final Phylogeny phy, final String confidence_type ) {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        while ( it.hasNext() ) {
-            transferInternalNodeNameToConfidence( confidence_type, it.next() );
-        }
-    }
-
-    private static void transferInternalNodeNameToConfidence( final String confidence_type, final PhylogenyNode n ) {
-        if ( !n.isExternal() && !n.getBranchData().isHasConfidences() ) {
-            if ( !ForesterUtil.isEmpty( n.getName() ) ) {
-                double d = -1.0;
-                try {
-                    d = Double.parseDouble( n.getName() );
-                }
-                catch ( final Exception e ) {
-                    d = -1.0;
-                }
-                if ( d >= 0.0 ) {
-                    n.getBranchData().addConfidence( new Confidence( d, confidence_type ) );
-                    n.setName( "" );
-                }
-            }
-        }
-    }
-
-    final static public void transferNodeNameToField( final Phylogeny phy,
-                                                      final PhylogenyNodeField field,
-                                                      final boolean external_only ) throws PhyloXmlDataFormatException {
-        final PhylogenyNodeIterator it = phy.iteratorPostorder();
-        while ( it.hasNext() ) {
-            final PhylogenyNode n = it.next();
-            if ( external_only && n.isInternal() ) {
-                continue;
-            }
-            final String name = n.getName().trim();
-            if ( !ForesterUtil.isEmpty( name ) ) {
-                switch ( field ) {
-                    case TAXONOMY_CODE:
-                        n.setName( "" );
-                        setTaxonomyCode( n, name );
-                        break;
-                    case TAXONOMY_SCIENTIFIC_NAME:
-                        n.setName( "" );
-                        if ( !n.getNodeData().isHasTaxonomy() ) {
-                            n.getNodeData().setTaxonomy( new Taxonomy() );
-                        }
-                        n.getNodeData().getTaxonomy().setScientificName( name );
-                        break;
-                    case TAXONOMY_COMMON_NAME:
-                        n.setName( "" );
-                        if ( !n.getNodeData().isHasTaxonomy() ) {
-                            n.getNodeData().setTaxonomy( new Taxonomy() );
-                        }
-                        n.getNodeData().getTaxonomy().setCommonName( name );
-                        break;
-                    case SEQUENCE_SYMBOL:
-                        n.setName( "" );
-                        if ( !n.getNodeData().isHasSequence() ) {
-                            n.getNodeData().setSequence( new Sequence() );
-                        }
-                        n.getNodeData().getSequence().setSymbol( name );
-                        break;
-                    case SEQUENCE_NAME:
-                        n.setName( "" );
-                        if ( !n.getNodeData().isHasSequence() ) {
-                            n.getNodeData().setSequence( new Sequence() );
-                        }
-                        n.getNodeData().getSequence().setName( name );
-                        break;
-                    case TAXONOMY_ID_UNIPROT_1: {
-                        if ( !n.getNodeData().isHasTaxonomy() ) {
-                            n.getNodeData().setTaxonomy( new Taxonomy() );
-                        }
-                        String id = name;
-                        final int i = name.indexOf( '_' );
-                        if ( i > 0 ) {
-                            id = name.substring( 0, i );
-                        }
-                        else {
-                            n.setName( "" );
-                        }
-                        n.getNodeData().getTaxonomy()
-                                .setIdentifier( new Identifier( id, PhyloXmlUtil.UNIPROT_TAX_PROVIDER ) );
-                        break;
-                    }
-                    case TAXONOMY_ID_UNIPROT_2: {
-                        if ( !n.getNodeData().isHasTaxonomy() ) {
-                            n.getNodeData().setTaxonomy( new Taxonomy() );
-                        }
-                        String id = name;
-                        final int i = name.indexOf( '_' );
-                        if ( i > 0 ) {
-                            id = name.substring( i + 1, name.length() );
-                        }
-                        else {
-                            n.setName( "" );
-                        }
-                        n.getNodeData().getTaxonomy()
-                                .setIdentifier( new Identifier( id, PhyloXmlUtil.UNIPROT_TAX_PROVIDER ) );
-                        break;
-                    }
-                    case TAXONOMY_ID: {
-                        if ( !n.getNodeData().isHasTaxonomy() ) {
-                            n.getNodeData().setTaxonomy( new Taxonomy() );
-                        }
-                        n.getNodeData().getTaxonomy().setIdentifier( new Identifier( name ) );
-                        break;
-                    }
-                }
-            }
-        }
-    }
-
-    static double addPhylogenyDistances( final double a, final double b ) {
-        if ( ( a >= 0.0 ) && ( b >= 0.0 ) ) {
-            return a + b;
-        }
-        else if ( a >= 0.0 ) {
-            return a;
-        }
-        else if ( b >= 0.0 ) {
-            return b;
-        }
-        return PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT;
-    }
-
-    static double calculateDistanceToAncestor( final PhylogenyNode anc, PhylogenyNode desc ) {
-        double d = 0;
-        boolean all_default = true;
-        while ( anc != desc ) {
-            if ( desc.getDistanceToParent() != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {
-                d += desc.getDistanceToParent();
-                if ( all_default ) {
-                    all_default = false;
-                }
-            }
-            desc = desc.getParent();
-        }
-        if ( all_default ) {
-            return PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT;
-        }
-        return d;
-    }
-
-    /**
-     * Deep copies the phylogeny originating from this node.
-     */
-    static PhylogenyNode copySubTree( final PhylogenyNode source ) {
-        if ( source == null ) {
-            return null;
-        }
-        else {
-            final PhylogenyNode newnode = source.copyNodeData();
-            if ( !source.isExternal() ) {
-                for( int i = 0; i < source.getNumberOfDescendants(); ++i ) {
-                    newnode.setChildNode( i, PhylogenyMethods.copySubTree( source.getChildNode( i ) ) );
-                }
-            }
-            return newnode;
-        }
-    }
-
-    /**
-     * Shallow copies the phylogeny originating from this node.
-     */
-    static PhylogenyNode copySubTreeShallow( final PhylogenyNode source ) {
-        if ( source == null ) {
-            return null;
-        }
-        else {
-            final PhylogenyNode newnode = source.copyNodeDataShallow();
-            if ( !source.isExternal() ) {
-                for( int i = 0; i < source.getNumberOfDescendants(); ++i ) {
-                    newnode.setChildNode( i, PhylogenyMethods.copySubTreeShallow( source.getChildNode( i ) ) );
-                }
-            }
-            return newnode;
-        }
-    }
-
-    private final static List<PhylogenyNode> divideIntoSubTreesHelper( final PhylogenyNode node,
-                                                                       final double min_distance_to_root ) {
-        final List<PhylogenyNode> l = new ArrayList<PhylogenyNode>();
-        final PhylogenyNode r = moveTowardsRoot( node, min_distance_to_root );
-        for( final PhylogenyNode ext : r.getAllExternalDescendants() ) {
-            if ( ext.getIndicator() != 0 ) {
-                throw new RuntimeException( "this should not have happened" );
-            }
-            ext.setIndicator( ( byte ) 1 );
-            l.add( ext );
-        }
-        return l;
-    }
-
-    /**
-     * Calculates the distance between PhylogenyNodes n1 and n2.
-     * PRECONDITION: n1 is a descendant of n2.
-     * 
-     * @param n1
-     *            a descendant of n2
-     * @param n2
-     * @return distance between n1 and n2
-     */
-    private static double getDistance( PhylogenyNode n1, final PhylogenyNode n2 ) {
-        double d = 0.0;
-        while ( n1 != n2 ) {
-            if ( n1.getDistanceToParent() > 0.0 ) {
-                d += n1.getDistanceToParent();
-            }
-            n1 = n1.getParent();
-        }
-        return d;
-    }
-
-    private static boolean match( final String s,
-                                  final String query,
-                                  final boolean case_sensitive,
-                                  final boolean partial ) {
-        if ( ForesterUtil.isEmpty( s ) || ForesterUtil.isEmpty( query ) ) {
-            return false;
-        }
-        String my_s = s.trim();
-        String my_query = query.trim();
-        if ( !case_sensitive ) {
-            my_s = my_s.toLowerCase();
-            my_query = my_query.toLowerCase();
-        }
-        if ( partial ) {
-            return my_s.indexOf( my_query ) >= 0;
-        }
-        else {
-            return Pattern.compile( "(\\b|_)" + Pattern.quote( my_query ) + "(\\b|_)" ).matcher( my_s ).find();
-        }
-    }
-
-    private final static PhylogenyNode moveTowardsRoot( final PhylogenyNode node, final double min_distance_to_root ) {
-        PhylogenyNode n = node;
-        PhylogenyNode prev = node;
-        while ( min_distance_to_root < n.calculateDistanceToRoot() ) {
-            prev = n;
-            n = n.getParent();
-        }
-        return prev;
-    }
-
-    public static enum DESCENDANT_SORT_PRIORITY {
-        NODE_NAME, SEQUENCE, TAXONOMY;
-    }
-
-    public static enum PhylogenyNodeField {
-        CLADE_NAME,
-        SEQUENCE_NAME,
-        SEQUENCE_SYMBOL,
-        TAXONOMY_CODE,
-        TAXONOMY_COMMON_NAME,
-        TAXONOMY_ID,
-        TAXONOMY_ID_UNIPROT_1,
-        TAXONOMY_ID_UNIPROT_2,
-        TAXONOMY_SCIENTIFIC_NAME;
-    }
-}
+// $Id:\r
+// FORESTER -- software libraries and applications\r
+// for evolutionary biology research and applications.\r
+//\r
+// Copyright (C) 2008-2009 Christian M. Zmasek\r
+// Copyright (C) 2008-2009 Burnham Institute for Medical Research\r
+// All rights reserved\r
+//\r
+// This library is free software; you can redistribute it and/or\r
+// modify it under the terms of the GNU Lesser General Public\r
+// License as published by the Free Software Foundation; either\r
+// version 2.1 of the License, or (at your option) any later version.\r
+//\r
+// This library is distributed in the hope that it will be useful,\r
+// but WITHOUT ANY WARRANTY; without even the implied warranty of\r
+// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU\r
+// Lesser General Public License for more details.\r
+//\r
+// You should have received a copy of the GNU Lesser General Public\r
+// License along with this library; if not, write to the Free Software\r
+// Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA 02110-1301, USA\r
+//\r
+// Contact: phylosoft @ gmail . com\r
+// WWW: https://sites.google.com/site/cmzmasek/home/software/forester\r
+\r
+package org.forester.phylogeny;\r
+\r
+import java.awt.Color;\r
+import java.io.File;\r
+import java.io.IOException;\r
+import java.util.ArrayList;\r
+import java.util.Arrays;\r
+import java.util.Collections;\r
+import java.util.Comparator;\r
+import java.util.HashMap;\r
+import java.util.HashSet;\r
+import java.util.Iterator;\r
+import java.util.List;\r
+import java.util.Map;\r
+import java.util.Set;\r
+import java.util.regex.Matcher;\r
+import java.util.regex.Pattern;\r
+\r
+import org.forester.io.parsers.FastaParser;\r
+import org.forester.io.parsers.PhylogenyParser;\r
+import org.forester.io.parsers.phyloxml.PhyloXmlDataFormatException;\r
+import org.forester.io.parsers.phyloxml.PhyloXmlUtil;\r
+import org.forester.io.parsers.util.PhylogenyParserException;\r
+import org.forester.phylogeny.data.Accession;\r
+import org.forester.phylogeny.data.Annotation;\r
+import org.forester.phylogeny.data.BranchColor;\r
+import org.forester.phylogeny.data.BranchWidth;\r
+import org.forester.phylogeny.data.Confidence;\r
+import org.forester.phylogeny.data.DomainArchitecture;\r
+import org.forester.phylogeny.data.Event;\r
+import org.forester.phylogeny.data.Identifier;\r
+import org.forester.phylogeny.data.PhylogenyDataUtil;\r
+import org.forester.phylogeny.data.Sequence;\r
+import org.forester.phylogeny.data.Taxonomy;\r
+import org.forester.phylogeny.factories.ParserBasedPhylogenyFactory;\r
+import org.forester.phylogeny.factories.PhylogenyFactory;\r
+import org.forester.phylogeny.iterators.PhylogenyNodeIterator;\r
+import org.forester.util.BasicDescriptiveStatistics;\r
+import org.forester.util.DescriptiveStatistics;\r
+import org.forester.util.ForesterUtil;\r
+\r
+public class PhylogenyMethods {\r
+\r
+    private PhylogenyMethods() {\r
+        // Hidden constructor.\r
+    }\r
+\r
+    @Override\r
+    public Object clone() throws CloneNotSupportedException {\r
+        throw new CloneNotSupportedException();\r
+    }\r
+\r
+    public static boolean extractFastaInformation( final Phylogeny phy ) {\r
+        boolean could_extract = false;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            if ( !ForesterUtil.isEmpty( node.getName() ) ) {\r
+                final Matcher name_m = FastaParser.FASTA_DESC_LINE.matcher( node.getName() );\r
+                if ( name_m.lookingAt() ) {\r
+                    could_extract = true;\r
+                    final String acc_source = name_m.group( 1 );\r
+                    final String acc = name_m.group( 2 );\r
+                    final String seq_name = name_m.group( 3 );\r
+                    final String tax_sn = name_m.group( 4 );\r
+                    if ( !ForesterUtil.isEmpty( acc_source ) && !ForesterUtil.isEmpty( acc ) ) {\r
+                        ForesterUtil.ensurePresenceOfSequence( node );\r
+                        node.getNodeData().getSequence( 0 ).setAccession( new Accession( acc, acc_source ) );\r
+                    }\r
+                    if ( !ForesterUtil.isEmpty( seq_name ) ) {\r
+                        ForesterUtil.ensurePresenceOfSequence( node );\r
+                        node.getNodeData().getSequence( 0 ).setName( seq_name );\r
+                    }\r
+                    if ( !ForesterUtil.isEmpty( tax_sn ) ) {\r
+                        ForesterUtil.ensurePresenceOfTaxonomy( node );\r
+                        node.getNodeData().getTaxonomy( 0 ).setScientificName( tax_sn );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        return could_extract;\r
+    }\r
+\r
+    public static DescriptiveStatistics calculatBranchLengthStatistics( final Phylogeny phy ) {\r
+        final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( !n.isRoot() && ( n.getDistanceToParent() >= 0.0 ) ) {\r
+                stats.addValue( n.getDistanceToParent() );\r
+            }\r
+        }\r
+        return stats;\r
+    }\r
+\r
+    public static List<DescriptiveStatistics> calculatConfidenceStatistics( final Phylogeny phy ) {\r
+        final List<DescriptiveStatistics> stats = new ArrayList<DescriptiveStatistics>();\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                if ( n.getBranchData().isHasConfidences() ) {\r
+                    for( int i = 0; i < n.getBranchData().getConfidences().size(); ++i ) {\r
+                        final Confidence c = n.getBranchData().getConfidences().get( i );\r
+                        if ( ( i > ( stats.size() - 1 ) ) || ( stats.get( i ) == null ) ) {\r
+                            stats.add( i, new BasicDescriptiveStatistics() );\r
+                        }\r
+                        if ( !ForesterUtil.isEmpty( c.getType() ) ) {\r
+                            if ( !ForesterUtil.isEmpty( stats.get( i ).getDescription() ) ) {\r
+                                if ( !stats.get( i ).getDescription().equalsIgnoreCase( c.getType() ) ) {\r
+                                    throw new IllegalArgumentException( "support values in node [" + n.toString()\r
+                                            + "] appear inconsistently ordered" );\r
+                                }\r
+                            }\r
+                            stats.get( i ).setDescription( c.getType() );\r
+                        }\r
+                        stats.get( i ).addValue( ( ( c != null ) && ( c.getValue() >= 0 ) ) ? c.getValue() : 0 );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        return stats;\r
+    }\r
+\r
+    /**\r
+     * Calculates the distance between PhylogenyNodes node1 and node2.\r
+     * \r
+     * \r
+     * @param node1\r
+     * @param node2\r
+     * @return distance between node1 and node2\r
+     */\r
+    public static double calculateDistance( final PhylogenyNode node1, final PhylogenyNode node2 ) {\r
+        final PhylogenyNode lca = calculateLCA( node1, node2 );\r
+        final PhylogenyNode n1 = node1;\r
+        final PhylogenyNode n2 = node2;\r
+        return ( PhylogenyMethods.getDistance( n1, lca ) + PhylogenyMethods.getDistance( n2, lca ) );\r
+    }\r
+\r
+    /**\r
+     * Returns the LCA of PhylogenyNodes node1 and node2.\r
+     * \r
+     * \r
+     * @param node1\r
+     * @param node2\r
+     * @return LCA of node1 and node2\r
+     */\r
+    public final static PhylogenyNode calculateLCA( PhylogenyNode node1, PhylogenyNode node2 ) {\r
+        if ( node1 == null ) {\r
+            throw new IllegalArgumentException( "first argument (node) is null" );\r
+        }\r
+        if ( node2 == null ) {\r
+            throw new IllegalArgumentException( "second argument (node) is null" );\r
+        }\r
+        if ( node1 == node2 ) {\r
+            return node1;\r
+        }\r
+        if ( ( node1.getParent() == node2.getParent() ) ) {\r
+            return node1.getParent();\r
+        }\r
+        int depth1 = node1.calculateDepth();\r
+        int depth2 = node2.calculateDepth();\r
+        while ( ( depth1 > -1 ) && ( depth2 > -1 ) ) {\r
+            if ( depth1 > depth2 ) {\r
+                node1 = node1.getParent();\r
+                depth1--;\r
+            }\r
+            else if ( depth2 > depth1 ) {\r
+                node2 = node2.getParent();\r
+                depth2--;\r
+            }\r
+            else {\r
+                if ( node1 == node2 ) {\r
+                    return node1;\r
+                }\r
+                node1 = node1.getParent();\r
+                node2 = node2.getParent();\r
+                depth1--;\r
+                depth2--;\r
+            }\r
+        }\r
+        throw new IllegalArgumentException( "illegal attempt to calculate LCA of two nodes which do not share a common root" );\r
+    }\r
+\r
+    /**\r
+     * Returns the LCA of PhylogenyNodes node1 and node2.\r
+     * Precondition: ids are in pre-order (or level-order).\r
+     * \r
+     * \r
+     * @param node1\r
+     * @param node2\r
+     * @return LCA of node1 and node2\r
+     */\r
+    public final static PhylogenyNode calculateLCAonTreeWithIdsInPreOrder( PhylogenyNode node1, PhylogenyNode node2 ) {\r
+        if ( node1 == null ) {\r
+            throw new IllegalArgumentException( "first argument (node) is null" );\r
+        }\r
+        if ( node2 == null ) {\r
+            throw new IllegalArgumentException( "second argument (node) is null" );\r
+        }\r
+        while ( node1 != node2 ) {\r
+            if ( node1.getId() > node2.getId() ) {\r
+                node1 = node1.getParent();\r
+            }\r
+            else {\r
+                node2 = node2.getParent();\r
+            }\r
+        }\r
+        return node1;\r
+    }\r
+\r
+    public static short calculateMaxBranchesToLeaf( final PhylogenyNode node ) {\r
+        if ( node.isExternal() ) {\r
+            return 0;\r
+        }\r
+        short max = 0;\r
+        for( PhylogenyNode d : node.getAllExternalDescendants() ) {\r
+            short steps = 0;\r
+            while ( d != node ) {\r
+                if ( d.isCollapse() ) {\r
+                    steps = 0;\r
+                }\r
+                else {\r
+                    steps++;\r
+                }\r
+                d = d.getParent();\r
+            }\r
+            if ( max < steps ) {\r
+                max = steps;\r
+            }\r
+        }\r
+        return max;\r
+    }\r
+\r
+    public static int calculateMaxDepth( final Phylogeny phy ) {\r
+        int max = 0;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            final int steps = node.calculateDepth();\r
+            if ( steps > max ) {\r
+                max = steps;\r
+            }\r
+        }\r
+        return max;\r
+    }\r
+\r
+    public static double calculateMaxDistanceToRoot( final Phylogeny phy ) {\r
+        double max = 0.0;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorExternalForward(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            final double d = node.calculateDistanceToRoot();\r
+            if ( d > max ) {\r
+                max = d;\r
+            }\r
+        }\r
+        return max;\r
+    }\r
+\r
+    public static int calculateNumberOfExternalNodesWithoutTaxonomy( final PhylogenyNode node ) {\r
+        final List<PhylogenyNode> descs = node.getAllExternalDescendants();\r
+        int x = 0;\r
+        for( final PhylogenyNode n : descs ) {\r
+            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {\r
+                x++;\r
+            }\r
+        }\r
+        return x;\r
+    }\r
+\r
+    public static DescriptiveStatistics calculatNumberOfDescendantsPerNodeStatistics( final Phylogeny phy ) {\r
+        final DescriptiveStatistics stats = new BasicDescriptiveStatistics();\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( !n.isExternal() ) {\r
+                stats.addValue( n.getNumberOfDescendants() );\r
+            }\r
+        }\r
+        return stats;\r
+    }\r
+\r
+    public final static void collapseSubtreeStructure( final PhylogenyNode n ) {\r
+        final List<PhylogenyNode> eds = n.getAllExternalDescendants();\r
+        final List<Double> d = new ArrayList<Double>();\r
+        for( final PhylogenyNode ed : eds ) {\r
+            d.add( calculateDistanceToAncestor( n, ed ) );\r
+        }\r
+        for( int i = 0; i < eds.size(); ++i ) {\r
+            n.setChildNode( i, eds.get( i ) );\r
+            eds.get( i ).setDistanceToParent( d.get( i ) );\r
+        }\r
+    }\r
+\r
+    public static int countNumberOfOneDescendantNodes( final Phylogeny phy ) {\r
+        int count = 0;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( !n.isExternal() && ( n.getNumberOfDescendants() == 1 ) ) {\r
+                count++;\r
+            }\r
+        }\r
+        return count;\r
+    }\r
+\r
+    public static int countNumberOfPolytomies( final Phylogeny phy ) {\r
+        int count = 0;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( !n.isExternal() && ( n.getNumberOfDescendants() > 2 ) ) {\r
+                count++;\r
+            }\r
+        }\r
+        return count;\r
+    }\r
+\r
+    public static final HashMap<String, PhylogenyNode> createNameToExtNodeMap( final Phylogeny phy ) {\r
+        final HashMap<String, PhylogenyNode> nodes = new HashMap<String, PhylogenyNode>();\r
+        final List<PhylogenyNode> ext = phy.getExternalNodes();\r
+        for( final PhylogenyNode n : ext ) {\r
+            nodes.put( n.getName(), n );\r
+        }\r
+        return nodes;\r
+    }\r
+\r
+    public static void deleteExternalNodesNegativeSelection( final Set<Long> to_delete, final Phylogeny phy ) {\r
+        for( final Long id : to_delete ) {\r
+            phy.deleteSubtree( phy.getNode( id ), true );\r
+        }\r
+        phy.clearHashIdToNodeMap();\r
+        phy.externalNodesHaveChanged();\r
+    }\r
+\r
+    public static void deleteExternalNodesNegativeSelection( final String[] node_names_to_delete, final Phylogeny p )\r
+            throws IllegalArgumentException {\r
+        for( final String element : node_names_to_delete ) {\r
+            if ( ForesterUtil.isEmpty( element ) ) {\r
+                continue;\r
+            }\r
+            List<PhylogenyNode> nodes = null;\r
+            nodes = p.getNodes( element );\r
+            final Iterator<PhylogenyNode> it = nodes.iterator();\r
+            while ( it.hasNext() ) {\r
+                final PhylogenyNode n = it.next();\r
+                if ( !n.isExternal() ) {\r
+                    throw new IllegalArgumentException( "attempt to delete non-external node \"" + element + "\"" );\r
+                }\r
+                p.deleteSubtree( n, true );\r
+            }\r
+        }\r
+        p.clearHashIdToNodeMap();\r
+        p.externalNodesHaveChanged();\r
+    }\r
+\r
+    public static List<String> deleteExternalNodesPositiveSelection( final String[] node_names_to_keep,\r
+                                                                     final Phylogeny p ) {\r
+        final PhylogenyNodeIterator it = p.iteratorExternalForward();\r
+        final String[] to_delete = new String[ p.getNumberOfExternalNodes() ];\r
+        int i = 0;\r
+        Arrays.sort( node_names_to_keep );\r
+        while ( it.hasNext() ) {\r
+            final String curent_name = it.next().getName();\r
+            if ( Arrays.binarySearch( node_names_to_keep, curent_name ) < 0 ) {\r
+                to_delete[ i++ ] = curent_name;\r
+            }\r
+        }\r
+        PhylogenyMethods.deleteExternalNodesNegativeSelection( to_delete, p );\r
+        final List<String> deleted = new ArrayList<String>();\r
+        for( final String n : to_delete ) {\r
+            if ( !ForesterUtil.isEmpty( n ) ) {\r
+                deleted.add( n );\r
+            }\r
+        }\r
+        return deleted;\r
+    }\r
+\r
+    public static void deleteExternalNodesPositiveSelectionT( final List<Taxonomy> species_to_keep, final Phylogeny phy ) {\r
+        final Set<Long> to_delete = new HashSet<Long>();\r
+        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( n.getNodeData().isHasTaxonomy() ) {\r
+                if ( !species_to_keep.contains( n.getNodeData().getTaxonomy() ) ) {\r
+                    to_delete.add( n.getId() );\r
+                }\r
+            }\r
+            else {\r
+                throw new IllegalArgumentException( "node " + n.getId() + " has no taxonomic data" );\r
+            }\r
+        }\r
+        deleteExternalNodesNegativeSelection( to_delete, phy );\r
+    }\r
+\r
+    final public static void deleteInternalNodesWithOnlyOneDescendent( final Phylogeny phy ) {\r
+        final ArrayList<PhylogenyNode> to_delete = new ArrayList<PhylogenyNode>();\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPostorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode n = iter.next();\r
+            if ( ( !n.isExternal() ) && ( n.getNumberOfDescendants() == 1 ) ) {\r
+                to_delete.add( n );\r
+            }\r
+        }\r
+        for( final PhylogenyNode d : to_delete ) {\r
+            PhylogenyMethods.removeNode( d, phy );\r
+        }\r
+        phy.clearHashIdToNodeMap();\r
+        phy.externalNodesHaveChanged();\r
+    }\r
+\r
+    final public static void deleteNonOrthologousExternalNodes( final Phylogeny phy, final PhylogenyNode n ) {\r
+        if ( n.isInternal() ) {\r
+            throw new IllegalArgumentException( "node is not external" );\r
+        }\r
+        final ArrayList<PhylogenyNode> to_delete = new ArrayList<PhylogenyNode>();\r
+        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {\r
+            final PhylogenyNode i = it.next();\r
+            if ( !PhylogenyMethods.getEventAtLCA( n, i ).isSpeciation() ) {\r
+                to_delete.add( i );\r
+            }\r
+        }\r
+        for( final PhylogenyNode d : to_delete ) {\r
+            phy.deleteSubtree( d, true );\r
+        }\r
+        phy.clearHashIdToNodeMap();\r
+        phy.externalNodesHaveChanged();\r
+    }\r
+\r
+    public final static List<List<PhylogenyNode>> divideIntoSubTrees( final Phylogeny phy,\r
+                                                                      final double min_distance_to_root ) {\r
+        if ( min_distance_to_root <= 0 ) {\r
+            throw new IllegalArgumentException( "attempt to use min distance to root of: " + min_distance_to_root );\r
+        }\r
+        final List<List<PhylogenyNode>> l = new ArrayList<List<PhylogenyNode>>();\r
+        setAllIndicatorsToZero( phy );\r
+        for( final PhylogenyNodeIterator it = phy.iteratorExternalForward(); it.hasNext(); ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( n.getIndicator() != 0 ) {\r
+                continue;\r
+            }\r
+            l.add( divideIntoSubTreesHelper( n, min_distance_to_root ) );\r
+            if ( l.isEmpty() ) {\r
+                throw new RuntimeException( "this should not have happened" );\r
+            }\r
+        }\r
+        return l;\r
+    }\r
+\r
+    public static List<PhylogenyNode> getAllDescendants( final PhylogenyNode node ) {\r
+        final List<PhylogenyNode> descs = new ArrayList<PhylogenyNode>();\r
+        final Set<Long> encountered = new HashSet<Long>();\r
+        if ( !node.isExternal() ) {\r
+            final List<PhylogenyNode> exts = node.getAllExternalDescendants();\r
+            for( PhylogenyNode current : exts ) {\r
+                descs.add( current );\r
+                while ( current != node ) {\r
+                    current = current.getParent();\r
+                    if ( encountered.contains( current.getId() ) ) {\r
+                        continue;\r
+                    }\r
+                    descs.add( current );\r
+                    encountered.add( current.getId() );\r
+                }\r
+            }\r
+        }\r
+        return descs;\r
+    }\r
+\r
+    /**\r
+     * \r
+     * Convenience method\r
+     * \r
+     * @param node\r
+     * @return\r
+     */\r
+    public static Color getBranchColorValue( final PhylogenyNode node ) {\r
+        if ( node.getBranchData().getBranchColor() == null ) {\r
+            return null;\r
+        }\r
+        return node.getBranchData().getBranchColor().getValue();\r
+    }\r
+\r
+    /**\r
+     * Convenience method\r
+     */\r
+    public static double getBranchWidthValue( final PhylogenyNode node ) {\r
+        if ( !node.getBranchData().isHasBranchWidth() ) {\r
+            return BranchWidth.BRANCH_WIDTH_DEFAULT_VALUE;\r
+        }\r
+        return node.getBranchData().getBranchWidth().getValue();\r
+    }\r
+\r
+    /**\r
+     * Convenience method\r
+     */\r
+    public static double getConfidenceValue( final PhylogenyNode node ) {\r
+        if ( !node.getBranchData().isHasConfidences() ) {\r
+            return Confidence.CONFIDENCE_DEFAULT_VALUE;\r
+        }\r
+        return node.getBranchData().getConfidence( 0 ).getValue();\r
+    }\r
+\r
+    /**\r
+     * Convenience method\r
+     */\r
+    public static double[] getConfidenceValuesAsArray( final PhylogenyNode node ) {\r
+        if ( !node.getBranchData().isHasConfidences() ) {\r
+            return new double[ 0 ];\r
+        }\r
+        final double[] values = new double[ node.getBranchData().getConfidences().size() ];\r
+        int i = 0;\r
+        for( final Confidence c : node.getBranchData().getConfidences() ) {\r
+            values[ i++ ] = c.getValue();\r
+        }\r
+        return values;\r
+    }\r
+\r
+    final public static Event getEventAtLCA( final PhylogenyNode n1, final PhylogenyNode n2 ) {\r
+        return calculateLCA( n1, n2 ).getNodeData().getEvent();\r
+    }\r
+\r
+    /**\r
+     * Returns taxonomy t if all external descendants have \r
+     * the same taxonomy t, null otherwise.\r
+     * \r
+     */\r
+    public static Taxonomy getExternalDescendantsTaxonomy( final PhylogenyNode node ) {\r
+        final List<PhylogenyNode> descs = node.getAllExternalDescendants();\r
+        Taxonomy tax = null;\r
+        for( final PhylogenyNode n : descs ) {\r
+            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {\r
+                return null;\r
+            }\r
+            else if ( tax == null ) {\r
+                tax = n.getNodeData().getTaxonomy();\r
+            }\r
+            else if ( n.getNodeData().getTaxonomy().isEmpty() || !tax.isEqual( n.getNodeData().getTaxonomy() ) ) {\r
+                return null;\r
+            }\r
+        }\r
+        return tax;\r
+    }\r
+\r
+    public static PhylogenyNode getFurthestDescendant( final PhylogenyNode node ) {\r
+        final List<PhylogenyNode> children = node.getAllExternalDescendants();\r
+        PhylogenyNode farthest = null;\r
+        double longest = -Double.MAX_VALUE;\r
+        for( final PhylogenyNode child : children ) {\r
+            if ( PhylogenyMethods.getDistance( child, node ) > longest ) {\r
+                farthest = child;\r
+                longest = PhylogenyMethods.getDistance( child, node );\r
+            }\r
+        }\r
+        return farthest;\r
+    }\r
+\r
+    // public static PhylogenyMethods getInstance() {\r
+    //     if ( PhylogenyMethods._instance == null ) {\r
+    //         PhylogenyMethods._instance = new PhylogenyMethods();\r
+    //    }\r
+    //    return PhylogenyMethods._instance;\r
+    //  }\r
+    /**\r
+     * Returns the largest confidence value found on phy.\r
+     */\r
+    static public double getMaximumConfidenceValue( final Phylogeny phy ) {\r
+        double max = -Double.MAX_VALUE;\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final double s = PhylogenyMethods.getConfidenceValue( iter.next() );\r
+            if ( ( s != Confidence.CONFIDENCE_DEFAULT_VALUE ) && ( s > max ) ) {\r
+                max = s;\r
+            }\r
+        }\r
+        return max;\r
+    }\r
+\r
+    static public int getMinimumDescendentsPerInternalNodes( final Phylogeny phy ) {\r
+        int min = Integer.MAX_VALUE;\r
+        int d = 0;\r
+        PhylogenyNode n;\r
+        for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {\r
+            n = it.next();\r
+            if ( n.isInternal() ) {\r
+                d = n.getNumberOfDescendants();\r
+                if ( d < min ) {\r
+                    min = d;\r
+                }\r
+            }\r
+        }\r
+        return min;\r
+    }\r
+\r
+    /**\r
+     * Convenience method for display purposes.\r
+     * Not intended for algorithms.\r
+     */\r
+    public static String getSpecies( final PhylogenyNode node ) {\r
+        if ( !node.getNodeData().isHasTaxonomy() ) {\r
+            return "";\r
+        }\r
+        else if ( !ForesterUtil.isEmpty( node.getNodeData().getTaxonomy().getScientificName() ) ) {\r
+            return node.getNodeData().getTaxonomy().getScientificName();\r
+        }\r
+        if ( !ForesterUtil.isEmpty( node.getNodeData().getTaxonomy().getTaxonomyCode() ) ) {\r
+            return node.getNodeData().getTaxonomy().getTaxonomyCode();\r
+        }\r
+        else {\r
+            return node.getNodeData().getTaxonomy().getCommonName();\r
+        }\r
+    }\r
+\r
+    /**\r
+     * Convenience method for display purposes.\r
+     * Not intended for algorithms.\r
+     */\r
+    public static String getTaxonomyIdentifier( final PhylogenyNode node ) {\r
+        if ( !node.getNodeData().isHasTaxonomy() || ( node.getNodeData().getTaxonomy().getIdentifier() == null ) ) {\r
+            return "";\r
+        }\r
+        return node.getNodeData().getTaxonomy().getIdentifier().getValue();\r
+    }\r
+\r
+    public final static boolean isAllDecendentsAreDuplications( final PhylogenyNode n ) {\r
+        if ( n.isExternal() ) {\r
+            return true;\r
+        }\r
+        else {\r
+            if ( n.isDuplication() ) {\r
+                for( final PhylogenyNode desc : n.getDescendants() ) {\r
+                    if ( !isAllDecendentsAreDuplications( desc ) ) {\r
+                        return false;\r
+                    }\r
+                }\r
+                return true;\r
+            }\r
+            else {\r
+                return false;\r
+            }\r
+        }\r
+    }\r
+\r
+    public static boolean isHasExternalDescendant( final PhylogenyNode node ) {\r
+        for( int i = 0; i < node.getNumberOfDescendants(); ++i ) {\r
+            if ( node.getChildNode( i ).isExternal() ) {\r
+                return true;\r
+            }\r
+        }\r
+        return false;\r
+    }\r
+\r
+    /*\r
+     * This is case insensitive.\r
+     * \r
+     */\r
+    public synchronized static boolean isTaxonomyHasIdentifierOfGivenProvider( final Taxonomy tax,\r
+                                                                               final String[] providers ) {\r
+        if ( ( tax.getIdentifier() != null ) && !ForesterUtil.isEmpty( tax.getIdentifier().getProvider() ) ) {\r
+            final String my_tax_prov = tax.getIdentifier().getProvider();\r
+            for( final String provider : providers ) {\r
+                if ( provider.equalsIgnoreCase( my_tax_prov ) ) {\r
+                    return true;\r
+                }\r
+            }\r
+            return false;\r
+        }\r
+        else {\r
+            return false;\r
+        }\r
+    }\r
+\r
+    public static void midpointRoot( final Phylogeny phylogeny ) {\r
+        if ( ( phylogeny.getNumberOfExternalNodes() < 2 ) || ( calculateMaxDistanceToRoot( phylogeny ) <= 0 ) ) {\r
+            return;\r
+        }\r
+        int counter = 0;\r
+        final int total_nodes = phylogeny.getNodeCount();\r
+        while ( true ) {\r
+            if ( ++counter > total_nodes ) {\r
+                throw new RuntimeException( "this should not have happened: midpoint rooting does not converge" );\r
+            }\r
+            PhylogenyNode a = null;\r
+            double da = 0;\r
+            double db = 0;\r
+            for( int i = 0; i < phylogeny.getRoot().getNumberOfDescendants(); ++i ) {\r
+                final PhylogenyNode f = getFurthestDescendant( phylogeny.getRoot().getChildNode( i ) );\r
+                final double df = getDistance( f, phylogeny.getRoot() );\r
+                if ( df > 0 ) {\r
+                    if ( df > da ) {\r
+                        db = da;\r
+                        da = df;\r
+                        a = f;\r
+                    }\r
+                    else if ( df > db ) {\r
+                        db = df;\r
+                    }\r
+                }\r
+            }\r
+            final double diff = da - db;\r
+            if ( diff < 0.000001 ) {\r
+                break;\r
+            }\r
+            double x = da - ( diff / 2.0 );\r
+            while ( ( x > a.getDistanceToParent() ) && !a.isRoot() ) {\r
+                x -= ( a.getDistanceToParent() > 0 ? a.getDistanceToParent() : 0 );\r
+                a = a.getParent();\r
+            }\r
+            phylogeny.reRoot( a, x );\r
+        }\r
+        phylogeny.recalculateNumberOfExternalDescendants( true );\r
+    }\r
+\r
+    public static void normalizeBootstrapValues( final Phylogeny phylogeny,\r
+                                                 final double max_bootstrap_value,\r
+                                                 final double max_normalized_value ) {\r
+        for( final PhylogenyNodeIterator iter = phylogeny.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            if ( node.isInternal() ) {\r
+                final double confidence = getConfidenceValue( node );\r
+                if ( confidence != Confidence.CONFIDENCE_DEFAULT_VALUE ) {\r
+                    if ( confidence >= max_bootstrap_value ) {\r
+                        setBootstrapConfidence( node, max_normalized_value );\r
+                    }\r
+                    else {\r
+                        setBootstrapConfidence( node, ( confidence * max_normalized_value ) / max_bootstrap_value );\r
+                    }\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    public static List<PhylogenyNode> obtainAllNodesAsList( final Phylogeny phy ) {\r
+        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();\r
+        if ( phy.isEmpty() ) {\r
+            return nodes;\r
+        }\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            nodes.add( iter.next() );\r
+        }\r
+        return nodes;\r
+    }\r
+\r
+    /**\r
+     * Returns a map of distinct taxonomies of\r
+     * all external nodes of node.\r
+     * If at least one of the external nodes has no taxonomy,\r
+     * null is returned.\r
+     * \r
+     */\r
+    public static Map<Taxonomy, Integer> obtainDistinctTaxonomyCounts( final PhylogenyNode node ) {\r
+        final List<PhylogenyNode> descs = node.getAllExternalDescendants();\r
+        final Map<Taxonomy, Integer> tax_map = new HashMap<Taxonomy, Integer>();\r
+        for( final PhylogenyNode n : descs ) {\r
+            if ( !n.getNodeData().isHasTaxonomy() || n.getNodeData().getTaxonomy().isEmpty() ) {\r
+                return null;\r
+            }\r
+            final Taxonomy t = n.getNodeData().getTaxonomy();\r
+            if ( tax_map.containsKey( t ) ) {\r
+                tax_map.put( t, tax_map.get( t ) + 1 );\r
+            }\r
+            else {\r
+                tax_map.put( t, 1 );\r
+            }\r
+        }\r
+        return tax_map;\r
+    }\r
+\r
+    /**\r
+     * Arranges the order of childern for each node of this Phylogeny in such a\r
+     * way that either the branch with more children is on top (right) or on\r
+     * bottom (left), dependent on the value of boolean order.\r
+     * \r
+     * @param order\r
+     *            decides in which direction to order\r
+     * @param pri \r
+     */\r
+    public static void orderAppearance( final PhylogenyNode n,\r
+                                        final boolean order,\r
+                                        final boolean order_ext_alphabetically,\r
+                                        final DESCENDANT_SORT_PRIORITY pri ) {\r
+        if ( n.isExternal() ) {\r
+            return;\r
+        }\r
+        else {\r
+            PhylogenyNode temp = null;\r
+            if ( ( n.getNumberOfDescendants() == 2 )\r
+                    && ( n.getChildNode1().getNumberOfExternalNodes() != n.getChildNode2().getNumberOfExternalNodes() )\r
+                    && ( ( n.getChildNode1().getNumberOfExternalNodes() < n.getChildNode2().getNumberOfExternalNodes() ) == order ) ) {\r
+                temp = n.getChildNode1();\r
+                n.setChild1( n.getChildNode2() );\r
+                n.setChild2( temp );\r
+            }\r
+            else if ( order_ext_alphabetically ) {\r
+                boolean all_ext = true;\r
+                for( final PhylogenyNode i : n.getDescendants() ) {\r
+                    if ( !i.isExternal() ) {\r
+                        all_ext = false;\r
+                        break;\r
+                    }\r
+                }\r
+                if ( all_ext ) {\r
+                    PhylogenyMethods.sortNodeDescendents( n, pri );\r
+                }\r
+            }\r
+            for( int i = 0; i < n.getNumberOfDescendants(); ++i ) {\r
+                orderAppearance( n.getChildNode( i ), order, order_ext_alphabetically, pri );\r
+            }\r
+        }\r
+    }\r
+\r
+    public static void postorderBranchColorAveragingExternalNodeBased( final Phylogeny p ) {\r
+        for( final PhylogenyNodeIterator iter = p.iteratorPostorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            double red = 0.0;\r
+            double green = 0.0;\r
+            double blue = 0.0;\r
+            int n = 0;\r
+            if ( node.isInternal() ) {\r
+                //for( final PhylogenyNodeIterator iterator = node.iterateChildNodesForward(); iterator.hasNext(); ) {\r
+                for( int i = 0; i < node.getNumberOfDescendants(); ++i ) {\r
+                    final PhylogenyNode child_node = node.getChildNode( i );\r
+                    final Color child_color = getBranchColorValue( child_node );\r
+                    if ( child_color != null ) {\r
+                        ++n;\r
+                        red += child_color.getRed();\r
+                        green += child_color.getGreen();\r
+                        blue += child_color.getBlue();\r
+                    }\r
+                }\r
+                setBranchColorValue( node,\r
+                                     new Color( ForesterUtil.roundToInt( red / n ),\r
+                                                ForesterUtil.roundToInt( green / n ),\r
+                                                ForesterUtil.roundToInt( blue / n ) ) );\r
+            }\r
+        }\r
+    }\r
+\r
+    public static final void preOrderReId( final Phylogeny phy ) {\r
+        if ( phy.isEmpty() ) {\r
+            return;\r
+        }\r
+        phy.setIdToNodeMap( null );\r
+        long i = PhylogenyNode.getNodeCount();\r
+        for( final PhylogenyNodeIterator it = phy.iteratorPreorder(); it.hasNext(); ) {\r
+            it.next().setId( i++ );\r
+        }\r
+        PhylogenyNode.setNodeCount( i );\r
+    }\r
+\r
+    public final static Phylogeny[] readPhylogenies( final PhylogenyParser parser, final File file ) throws IOException {\r
+        final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();\r
+        final Phylogeny[] trees = factory.create( file, parser );\r
+        if ( ( trees == null ) || ( trees.length == 0 ) ) {\r
+            throw new PhylogenyParserException( "Unable to parse phylogeny from file: " + file );\r
+        }\r
+        return trees;\r
+    }\r
+\r
+    public final static Phylogeny[] readPhylogenies( final PhylogenyParser parser, final List<File> files )\r
+            throws IOException {\r
+        final List<Phylogeny> tree_list = new ArrayList<Phylogeny>();\r
+        for( final File file : files ) {\r
+            final PhylogenyFactory factory = ParserBasedPhylogenyFactory.getInstance();\r
+            final Phylogeny[] trees = factory.create( file, parser );\r
+            if ( ( trees == null ) || ( trees.length == 0 ) ) {\r
+                throw new PhylogenyParserException( "Unable to parse phylogeny from file: " + file );\r
+            }\r
+            tree_list.addAll( Arrays.asList( trees ) );\r
+        }\r
+        return tree_list.toArray( new Phylogeny[ tree_list.size() ] );\r
+    }\r
+\r
+    public static void removeNode( final PhylogenyNode remove_me, final Phylogeny phylogeny ) {\r
+        if ( remove_me.isRoot() ) {\r
+            if ( remove_me.getNumberOfDescendants() == 1 ) {\r
+                final PhylogenyNode desc = remove_me.getDescendants().get( 0 );\r
+                desc.setDistanceToParent( addPhylogenyDistances( remove_me.getDistanceToParent(),\r
+                                                                 desc.getDistanceToParent() ) );\r
+                desc.setParent( null );\r
+                phylogeny.setRoot( desc );\r
+                phylogeny.clearHashIdToNodeMap();\r
+            }\r
+            else {\r
+                throw new IllegalArgumentException( "attempt to remove a root node with more than one descendants" );\r
+            }\r
+        }\r
+        else if ( remove_me.isExternal() ) {\r
+            phylogeny.deleteSubtree( remove_me, false );\r
+            phylogeny.clearHashIdToNodeMap();\r
+            phylogeny.externalNodesHaveChanged();\r
+        }\r
+        else {\r
+            final PhylogenyNode parent = remove_me.getParent();\r
+            final List<PhylogenyNode> descs = remove_me.getDescendants();\r
+            parent.removeChildNode( remove_me );\r
+            for( final PhylogenyNode desc : descs ) {\r
+                parent.addAsChild( desc );\r
+                desc.setDistanceToParent( addPhylogenyDistances( remove_me.getDistanceToParent(),\r
+                                                                 desc.getDistanceToParent() ) );\r
+            }\r
+            remove_me.setParent( null );\r
+            phylogeny.clearHashIdToNodeMap();\r
+            phylogeny.externalNodesHaveChanged();\r
+        }\r
+    }\r
+\r
+    public static List<PhylogenyNode> searchData( final String query,\r
+                                                  final Phylogeny phy,\r
+                                                  final boolean case_sensitive,\r
+                                                  final boolean partial,\r
+                                                  final boolean search_domains ) {\r
+        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();\r
+        if ( phy.isEmpty() || ( query == null ) ) {\r
+            return nodes;\r
+        }\r
+        if ( ForesterUtil.isEmpty( query ) ) {\r
+            return nodes;\r
+        }\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            boolean match = false;\r
+            if ( match( node.getName(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            else if ( node.getNodeData().isHasTaxonomy()\r
+                    && match( node.getNodeData().getTaxonomy().getTaxonomyCode(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            else if ( node.getNodeData().isHasTaxonomy()\r
+                    && match( node.getNodeData().getTaxonomy().getCommonName(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            else if ( node.getNodeData().isHasTaxonomy()\r
+                    && match( node.getNodeData().getTaxonomy().getScientificName(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            else if ( node.getNodeData().isHasTaxonomy()\r
+                    && ( node.getNodeData().getTaxonomy().getIdentifier() != null )\r
+                    && match( node.getNodeData().getTaxonomy().getIdentifier().getValue(),\r
+                              query,\r
+                              case_sensitive,\r
+                              partial ) ) {\r
+                match = true;\r
+            }\r
+            else if ( node.getNodeData().isHasTaxonomy() && !node.getNodeData().getTaxonomy().getSynonyms().isEmpty() ) {\r
+                final List<String> syns = node.getNodeData().getTaxonomy().getSynonyms();\r
+                I: for( final String syn : syns ) {\r
+                    if ( match( syn, query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break I;\r
+                    }\r
+                }\r
+            }\r
+            if ( !match && node.getNodeData().isHasSequence()\r
+                    && match( node.getNodeData().getSequence().getName(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            if ( !match && node.getNodeData().isHasSequence()\r
+                    && match( node.getNodeData().getSequence().getGeneName(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            if ( !match && node.getNodeData().isHasSequence()\r
+                    && match( node.getNodeData().getSequence().getSymbol(), query, case_sensitive, partial ) ) {\r
+                match = true;\r
+            }\r
+            if ( !match\r
+                    && node.getNodeData().isHasSequence()\r
+                    && ( node.getNodeData().getSequence().getAccession() != null )\r
+                    && match( node.getNodeData().getSequence().getAccession().getValue(),\r
+                              query,\r
+                              case_sensitive,\r
+                              partial ) ) {\r
+                match = true;\r
+            }\r
+            if ( search_domains && !match && node.getNodeData().isHasSequence()\r
+                    && ( node.getNodeData().getSequence().getDomainArchitecture() != null ) ) {\r
+                final DomainArchitecture da = node.getNodeData().getSequence().getDomainArchitecture();\r
+                I: for( int i = 0; i < da.getNumberOfDomains(); ++i ) {\r
+                    if ( match( da.getDomain( i ).getName(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break I;\r
+                    }\r
+                }\r
+            }\r
+            //\r
+            if ( !match && node.getNodeData().isHasSequence()\r
+                    && ( node.getNodeData().getSequence().getAnnotations() != null ) ) {\r
+                for( final Annotation ann : node.getNodeData().getSequence().getAnnotations() ) {\r
+                    if ( match( ann.getDesc(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break;\r
+                    }\r
+                    if ( match( ann.getRef(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break;\r
+                    }\r
+                }\r
+            }\r
+            if ( !match && node.getNodeData().isHasSequence()\r
+                    && ( node.getNodeData().getSequence().getCrossReferences() != null ) ) {\r
+                for( final Accession x : node.getNodeData().getSequence().getCrossReferences() ) {\r
+                    if ( match( x.getComment(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break;\r
+                    }\r
+                    if ( match( x.getSource(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break;\r
+                    }\r
+                    if ( match( x.getValue(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break;\r
+                    }\r
+                }\r
+            }\r
+            //\r
+            if ( !match && ( node.getNodeData().getBinaryCharacters() != null ) ) {\r
+                Iterator<String> it = node.getNodeData().getBinaryCharacters().getPresentCharacters().iterator();\r
+                I: while ( it.hasNext() ) {\r
+                    if ( match( it.next(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break I;\r
+                    }\r
+                }\r
+                it = node.getNodeData().getBinaryCharacters().getGainedCharacters().iterator();\r
+                I: while ( it.hasNext() ) {\r
+                    if ( match( it.next(), query, case_sensitive, partial ) ) {\r
+                        match = true;\r
+                        break I;\r
+                    }\r
+                }\r
+            }\r
+            if ( match ) {\r
+                nodes.add( node );\r
+            }\r
+        }\r
+        return nodes;\r
+    }\r
+\r
+    public static List<PhylogenyNode> searchDataLogicalAnd( final String[] queries,\r
+                                                            final Phylogeny phy,\r
+                                                            final boolean case_sensitive,\r
+                                                            final boolean partial,\r
+                                                            final boolean search_domains ) {\r
+        final List<PhylogenyNode> nodes = new ArrayList<PhylogenyNode>();\r
+        if ( phy.isEmpty() || ( queries == null ) || ( queries.length < 1 ) ) {\r
+            return nodes;\r
+        }\r
+        for( final PhylogenyNodeIterator iter = phy.iteratorPreorder(); iter.hasNext(); ) {\r
+            final PhylogenyNode node = iter.next();\r
+            boolean all_matched = true;\r
+            for( final String query : queries ) {\r
+                boolean match = false;\r
+                if ( ForesterUtil.isEmpty( query ) ) {\r
+                    continue;\r
+                }\r
+                if ( match( node.getName(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                else if ( node.getNodeData().isHasTaxonomy()\r
+                        && match( node.getNodeData().getTaxonomy().getTaxonomyCode(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                else if ( node.getNodeData().isHasTaxonomy()\r
+                        && match( node.getNodeData().getTaxonomy().getCommonName(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                else if ( node.getNodeData().isHasTaxonomy()\r
+                        && match( node.getNodeData().getTaxonomy().getScientificName(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                else if ( node.getNodeData().isHasTaxonomy()\r
+                        && ( node.getNodeData().getTaxonomy().getIdentifier() != null )\r
+                        && match( node.getNodeData().getTaxonomy().getIdentifier().getValue(),\r
+                                  query,\r
+                                  case_sensitive,\r
+                                  partial ) ) {\r
+                    match = true;\r
+                }\r
+                else if ( node.getNodeData().isHasTaxonomy()\r
+                        && !node.getNodeData().getTaxonomy().getSynonyms().isEmpty() ) {\r
+                    final List<String> syns = node.getNodeData().getTaxonomy().getSynonyms();\r
+                    I: for( final String syn : syns ) {\r
+                        if ( match( syn, query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break I;\r
+                        }\r
+                    }\r
+                }\r
+                if ( !match && node.getNodeData().isHasSequence()\r
+                        && match( node.getNodeData().getSequence().getName(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                if ( !match && node.getNodeData().isHasSequence()\r
+                        && match( node.getNodeData().getSequence().getGeneName(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                if ( !match && node.getNodeData().isHasSequence()\r
+                        && match( node.getNodeData().getSequence().getSymbol(), query, case_sensitive, partial ) ) {\r
+                    match = true;\r
+                }\r
+                if ( !match\r
+                        && node.getNodeData().isHasSequence()\r
+                        && ( node.getNodeData().getSequence().getAccession() != null )\r
+                        && match( node.getNodeData().getSequence().getAccession().getValue(),\r
+                                  query,\r
+                                  case_sensitive,\r
+                                  partial ) ) {\r
+                    match = true;\r
+                }\r
+                if ( search_domains && !match && node.getNodeData().isHasSequence()\r
+                        && ( node.getNodeData().getSequence().getDomainArchitecture() != null ) ) {\r
+                    final DomainArchitecture da = node.getNodeData().getSequence().getDomainArchitecture();\r
+                    I: for( int i = 0; i < da.getNumberOfDomains(); ++i ) {\r
+                        if ( match( da.getDomain( i ).getName(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break I;\r
+                        }\r
+                    }\r
+                }\r
+                //\r
+                if ( !match && node.getNodeData().isHasSequence()\r
+                        && ( node.getNodeData().getSequence().getAnnotations() != null ) ) {\r
+                    for( final Annotation ann : node.getNodeData().getSequence().getAnnotations() ) {\r
+                        if ( match( ann.getDesc(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break;\r
+                        }\r
+                        if ( match( ann.getRef(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break;\r
+                        }\r
+                    }\r
+                }\r
+                if ( !match && node.getNodeData().isHasSequence()\r
+                        && ( node.getNodeData().getSequence().getCrossReferences() != null ) ) {\r
+                    for( final Accession x : node.getNodeData().getSequence().getCrossReferences() ) {\r
+                        if ( match( x.getComment(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break;\r
+                        }\r
+                        if ( match( x.getSource(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break;\r
+                        }\r
+                        if ( match( x.getValue(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break;\r
+                        }\r
+                    }\r
+                }\r
+                //\r
+                if ( !match && ( node.getNodeData().getBinaryCharacters() != null ) ) {\r
+                    Iterator<String> it = node.getNodeData().getBinaryCharacters().getPresentCharacters().iterator();\r
+                    I: while ( it.hasNext() ) {\r
+                        if ( match( it.next(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break I;\r
+                        }\r
+                    }\r
+                    it = node.getNodeData().getBinaryCharacters().getGainedCharacters().iterator();\r
+                    I: while ( it.hasNext() ) {\r
+                        if ( match( it.next(), query, case_sensitive, partial ) ) {\r
+                            match = true;\r
+                            break I;\r
+                        }\r
+                    }\r
+                }\r
+                if ( !match ) {\r
+                    all_matched = false;\r
+                    break;\r
+                }\r
+            }\r
+            if ( all_matched ) {\r
+                nodes.add( node );\r
+            }\r
+        }\r
+        return nodes;\r
+    }\r
+\r
+    public static void setAllIndicatorsToZero( final Phylogeny phy ) {\r
+        for( final PhylogenyNodeIterator it = phy.iteratorPostorder(); it.hasNext(); ) {\r
+            it.next().setIndicator( ( byte ) 0 );\r
+        }\r
+    }\r
+\r
+    /**\r
+     * Convenience method.\r
+     * Sets value for the first confidence value (created if not present, values overwritten otherwise). \r
+     */\r
+    public static void setBootstrapConfidence( final PhylogenyNode node, final double bootstrap_confidence_value ) {\r
+        setConfidence( node, bootstrap_confidence_value, "bootstrap" );\r
+    }\r
+\r
+    public static void setBranchColorValue( final PhylogenyNode node, final Color color ) {\r
+        if ( node.getBranchData().getBranchColor() == null ) {\r
+            node.getBranchData().setBranchColor( new BranchColor() );\r
+        }\r
+        node.getBranchData().getBranchColor().setValue( color );\r
+    }\r
+\r
+    /**\r
+     * Convenience method\r
+     */\r
+    public static void setBranchWidthValue( final PhylogenyNode node, final double branch_width_value ) {\r
+        node.getBranchData().setBranchWidth( new BranchWidth( branch_width_value ) );\r
+    }\r
+\r
+    /**\r
+     * Convenience method.\r
+     * Sets value for the first confidence value (created if not present, values overwritten otherwise). \r
+     */\r
+    public static void setConfidence( final PhylogenyNode node, final double confidence_value ) {\r
+        setConfidence( node, confidence_value, "" );\r
+    }\r
+\r
+    /**\r
+     * Convenience method.\r
+     * Sets value for the first confidence value (created if not present, values overwritten otherwise). \r
+     */\r
+    public static void setConfidence( final PhylogenyNode node, final double confidence_value, final String type ) {\r
+        Confidence c = null;\r
+        if ( node.getBranchData().getNumberOfConfidences() > 0 ) {\r
+            c = node.getBranchData().getConfidence( 0 );\r
+        }\r
+        else {\r
+            c = new Confidence();\r
+            node.getBranchData().addConfidence( c );\r
+        }\r
+        c.setType( type );\r
+        c.setValue( confidence_value );\r
+    }\r
+\r
+    public static void setScientificName( final PhylogenyNode node, final String scientific_name ) {\r
+        if ( !node.getNodeData().isHasTaxonomy() ) {\r
+            node.getNodeData().setTaxonomy( new Taxonomy() );\r
+        }\r
+        node.getNodeData().getTaxonomy().setScientificName( scientific_name );\r
+    }\r
+\r
+    /**\r
+     * Convenience method to set the taxonomy code of a phylogeny node.\r
+     * \r
+     * \r
+     * @param node\r
+     * @param taxonomy_code\r
+     * @throws PhyloXmlDataFormatException \r
+     */\r
+    public static void setTaxonomyCode( final PhylogenyNode node, final String taxonomy_code )\r
+            throws PhyloXmlDataFormatException {\r
+        if ( !node.getNodeData().isHasTaxonomy() ) {\r
+            node.getNodeData().setTaxonomy( new Taxonomy() );\r
+        }\r
+        node.getNodeData().getTaxonomy().setTaxonomyCode( taxonomy_code );\r
+    }\r
+\r
+    final static public void sortNodeDescendents( final PhylogenyNode node, final DESCENDANT_SORT_PRIORITY pri ) {\r
+        class PhylogenyNodeSortTaxonomyPriority implements Comparator<PhylogenyNode> {\r
+\r
+            @Override\r
+            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {\r
+                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );\r
+                    }\r
+                }\r
+                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getSymbol()\r
+                                .compareTo( n2.getNodeData().getSequence().getSymbol() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getGeneName()\r
+                                .compareTo( n2.getNodeData().getSequence().getGeneName() );\r
+                    }\r
+                    if ( ( n1.getNodeData().getSequence().getAccession() != null )\r
+                            && ( n2.getNodeData().getSequence().getAccession() != null )\r
+                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )\r
+                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {\r
+                        return n1.getNodeData().getSequence().getAccession().getValue()\r
+                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );\r
+                    }\r
+                }\r
+                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {\r
+                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );\r
+                }\r
+                return 0;\r
+            }\r
+        }\r
+        class PhylogenyNodeSortSequencePriority implements Comparator<PhylogenyNode> {\r
+\r
+            @Override\r
+            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {\r
+                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getSymbol()\r
+                                .compareTo( n2.getNodeData().getSequence().getSymbol() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getGeneName()\r
+                                .compareTo( n2.getNodeData().getSequence().getGeneName() );\r
+                    }\r
+                    if ( ( n1.getNodeData().getSequence().getAccession() != null )\r
+                            && ( n2.getNodeData().getSequence().getAccession() != null )\r
+                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )\r
+                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {\r
+                        return n1.getNodeData().getSequence().getAccession().getValue()\r
+                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );\r
+                    }\r
+                }\r
+                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );\r
+                    }\r
+                }\r
+                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {\r
+                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );\r
+                }\r
+                return 0;\r
+            }\r
+        }\r
+        class PhylogenyNodeSortNodeNamePriority implements Comparator<PhylogenyNode> {\r
+\r
+            @Override\r
+            public int compare( final PhylogenyNode n1, final PhylogenyNode n2 ) {\r
+                if ( ( !ForesterUtil.isEmpty( n1.getName() ) ) && ( !ForesterUtil.isEmpty( n2.getName() ) ) ) {\r
+                    return n1.getName().toLowerCase().compareTo( n2.getName().toLowerCase() );\r
+                }\r
+                if ( n1.getNodeData().isHasTaxonomy() && n2.getNodeData().isHasTaxonomy() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getScientificName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getScientificName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getScientificName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getScientificName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getTaxonomyCode() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getTaxonomyCode() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getTaxonomyCode()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getTaxonomyCode() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getTaxonomy().getCommonName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getTaxonomy().getCommonName() ) ) ) {\r
+                        return n1.getNodeData().getTaxonomy().getCommonName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getTaxonomy().getCommonName().toLowerCase() );\r
+                    }\r
+                }\r
+                if ( n1.getNodeData().isHasSequence() && n2.getNodeData().isHasSequence() ) {\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getName().toLowerCase()\r
+                                .compareTo( n2.getNodeData().getSequence().getName().toLowerCase() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getSymbol() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getSymbol() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getSymbol()\r
+                                .compareTo( n2.getNodeData().getSequence().getSymbol() );\r
+                    }\r
+                    if ( ( !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getGeneName() ) )\r
+                            && ( !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getGeneName() ) ) ) {\r
+                        return n1.getNodeData().getSequence().getGeneName()\r
+                                .compareTo( n2.getNodeData().getSequence().getGeneName() );\r
+                    }\r
+                    if ( ( n1.getNodeData().getSequence().getAccession() != null )\r
+                            && ( n2.getNodeData().getSequence().getAccession() != null )\r
+                            && !ForesterUtil.isEmpty( n1.getNodeData().getSequence().getAccession().getValue() )\r
+                            && !ForesterUtil.isEmpty( n2.getNodeData().getSequence().getAccession().getValue() ) ) {\r
+                        return n1.getNodeData().getSequence().getAccession().getValue()\r
+                                .compareTo( n2.getNodeData().getSequence().getAccession().getValue() );\r
+                    }\r
+                }\r
+                return 0;\r
+            }\r
+        }\r
+        Comparator<PhylogenyNode> c;\r
+        switch ( pri ) {\r
+            case SEQUENCE:\r
+                c = new PhylogenyNodeSortSequencePriority();\r
+                break;\r
+            case NODE_NAME:\r
+                c = new PhylogenyNodeSortNodeNamePriority();\r
+                break;\r
+            default:\r
+                c = new PhylogenyNodeSortTaxonomyPriority();\r
+        }\r
+        final List<PhylogenyNode> descs = node.getDescendants();\r
+        Collections.sort( descs, c );\r
+        int i = 0;\r
+        for( final PhylogenyNode desc : descs ) {\r
+            node.setChildNode( i++, desc );\r
+        }\r
+    }\r
+\r
+    /**\r
+     * Removes from Phylogeny to_be_stripped all external Nodes which are\r
+     * associated with a species NOT found in Phylogeny reference.\r
+     * \r
+     * @param reference\r
+     *            a reference Phylogeny\r
+     * @param to_be_stripped\r
+     *            Phylogeny to be stripped\r
+     * @return nodes removed from to_be_stripped\r
+     */\r
+    public static List<PhylogenyNode> taxonomyBasedDeletionOfExternalNodes( final Phylogeny reference,\r
+                                                                            final Phylogeny to_be_stripped ) {\r
+        final Set<String> ref_ext_taxo = new HashSet<String>();\r
+        for( final PhylogenyNodeIterator it = reference.iteratorExternalForward(); it.hasNext(); ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                throw new IllegalArgumentException( "no taxonomic data in node: " + n );\r
+            }\r
+            if ( !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getScientificName() ) ) {\r
+                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getScientificName() );\r
+            }\r
+            if ( !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getTaxonomyCode() ) ) {\r
+                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getTaxonomyCode() );\r
+            }\r
+            if ( ( n.getNodeData().getTaxonomy().getIdentifier() != null )\r
+                    && !ForesterUtil.isEmpty( n.getNodeData().getTaxonomy().getIdentifier().getValue() ) ) {\r
+                ref_ext_taxo.add( n.getNodeData().getTaxonomy().getIdentifier().getValuePlusProvider() );\r
+            }\r
+        }\r
+        final ArrayList<PhylogenyNode> nodes_to_delete = new ArrayList<PhylogenyNode>();\r
+        for( final PhylogenyNodeIterator it = to_be_stripped.iteratorExternalForward(); it.hasNext(); ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                nodes_to_delete.add( n );\r
+            }\r
+            else if ( !( ref_ext_taxo.contains( n.getNodeData().getTaxonomy().getScientificName() ) )\r
+                    && !( ref_ext_taxo.contains( n.getNodeData().getTaxonomy().getTaxonomyCode() ) )\r
+                    && !( ( n.getNodeData().getTaxonomy().getIdentifier() != null ) && ref_ext_taxo.contains( n\r
+                            .getNodeData().getTaxonomy().getIdentifier().getValuePlusProvider() ) ) ) {\r
+                nodes_to_delete.add( n );\r
+            }\r
+        }\r
+        for( final PhylogenyNode n : nodes_to_delete ) {\r
+            to_be_stripped.deleteSubtree( n, true );\r
+        }\r
+        to_be_stripped.clearHashIdToNodeMap();\r
+        to_be_stripped.externalNodesHaveChanged();\r
+        return nodes_to_delete;\r
+    }\r
+\r
+    final static public void transferInternalNamesToBootstrapSupport( final Phylogeny phy ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !ForesterUtil.isEmpty( n.getName() ) ) {\r
+                double value = -1;\r
+                try {\r
+                    value = Double.parseDouble( n.getName() );\r
+                }\r
+                catch ( final NumberFormatException e ) {\r
+                    throw new IllegalArgumentException( "failed to parse number from [" + n.getName() + "]: "\r
+                            + e.getLocalizedMessage() );\r
+                }\r
+                if ( value >= 0.0 ) {\r
+                    n.getBranchData().addConfidence( new Confidence( value, "bootstrap" ) );\r
+                    n.setName( "" );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    final static public boolean isInternalNamesLookLikeConfidences( final Phylogeny phy ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( !n.isExternal() && !n.isRoot() ) {\r
+                if ( !ForesterUtil.isEmpty( n.getName() ) ) {\r
+                    double value = -1;\r
+                    try {\r
+                        value = Double.parseDouble( n.getName() );\r
+                    }\r
+                    catch ( final NumberFormatException e ) {\r
+                        return false;\r
+                    }\r
+                    if ( ( value < 0.0 ) || ( value > 100 ) ) {\r
+                        return false;\r
+                    }\r
+                }\r
+            }\r
+        }\r
+        return true;\r
+    }\r
+\r
+    final static public void transferInternalNodeNamesToConfidence( final Phylogeny phy, final String confidence_type ) {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        while ( it.hasNext() ) {\r
+            transferInternalNodeNameToConfidence( confidence_type, it.next() );\r
+        }\r
+    }\r
+\r
+    private static void transferInternalNodeNameToConfidence( final String confidence_type, final PhylogenyNode n ) {\r
+        if ( !n.isExternal() && !n.getBranchData().isHasConfidences() ) {\r
+            if ( !ForesterUtil.isEmpty( n.getName() ) ) {\r
+                double d = -1.0;\r
+                try {\r
+                    d = Double.parseDouble( n.getName() );\r
+                }\r
+                catch ( final Exception e ) {\r
+                    d = -1.0;\r
+                }\r
+                if ( d >= 0.0 ) {\r
+                    n.getBranchData().addConfidence( new Confidence( d, confidence_type ) );\r
+                    n.setName( "" );\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    final static public void transferNodeNameToField( final Phylogeny phy,\r
+                                                      final PhylogenyNodeField field,\r
+                                                      final boolean external_only ) throws PhyloXmlDataFormatException {\r
+        final PhylogenyNodeIterator it = phy.iteratorPostorder();\r
+        while ( it.hasNext() ) {\r
+            final PhylogenyNode n = it.next();\r
+            if ( external_only && n.isInternal() ) {\r
+                continue;\r
+            }\r
+            final String name = n.getName().trim();\r
+            if ( !ForesterUtil.isEmpty( name ) ) {\r
+                switch ( field ) {\r
+                    case TAXONOMY_CODE:\r
+                        n.setName( "" );\r
+                        setTaxonomyCode( n, name );\r
+                        break;\r
+                    case TAXONOMY_SCIENTIFIC_NAME:\r
+                        n.setName( "" );\r
+                        if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                            n.getNodeData().setTaxonomy( new Taxonomy() );\r
+                        }\r
+                        n.getNodeData().getTaxonomy().setScientificName( name );\r
+                        break;\r
+                    case TAXONOMY_COMMON_NAME:\r
+                        n.setName( "" );\r
+                        if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                            n.getNodeData().setTaxonomy( new Taxonomy() );\r
+                        }\r
+                        n.getNodeData().getTaxonomy().setCommonName( name );\r
+                        break;\r
+                    case SEQUENCE_SYMBOL:\r
+                        n.setName( "" );\r
+                        if ( !n.getNodeData().isHasSequence() ) {\r
+                            n.getNodeData().setSequence( new Sequence() );\r
+                        }\r
+                        n.getNodeData().getSequence().setSymbol( name );\r
+                        break;\r
+                    case SEQUENCE_NAME:\r
+                        n.setName( "" );\r
+                        if ( !n.getNodeData().isHasSequence() ) {\r
+                            n.getNodeData().setSequence( new Sequence() );\r
+                        }\r
+                        n.getNodeData().getSequence().setName( name );\r
+                        break;\r
+                    case TAXONOMY_ID_UNIPROT_1: {\r
+                        if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                            n.getNodeData().setTaxonomy( new Taxonomy() );\r
+                        }\r
+                        String id = name;\r
+                        final int i = name.indexOf( '_' );\r
+                        if ( i > 0 ) {\r
+                            id = name.substring( 0, i );\r
+                        }\r
+                        else {\r
+                            n.setName( "" );\r
+                        }\r
+                        n.getNodeData().getTaxonomy()\r
+                                .setIdentifier( new Identifier( id, PhyloXmlUtil.UNIPROT_TAX_PROVIDER ) );\r
+                        break;\r
+                    }\r
+                    case TAXONOMY_ID_UNIPROT_2: {\r
+                        if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                            n.getNodeData().setTaxonomy( new Taxonomy() );\r
+                        }\r
+                        String id = name;\r
+                        final int i = name.indexOf( '_' );\r
+                        if ( i > 0 ) {\r
+                            id = name.substring( i + 1, name.length() );\r
+                        }\r
+                        else {\r
+                            n.setName( "" );\r
+                        }\r
+                        n.getNodeData().getTaxonomy()\r
+                                .setIdentifier( new Identifier( id, PhyloXmlUtil.UNIPROT_TAX_PROVIDER ) );\r
+                        break;\r
+                    }\r
+                    case TAXONOMY_ID: {\r
+                        if ( !n.getNodeData().isHasTaxonomy() ) {\r
+                            n.getNodeData().setTaxonomy( new Taxonomy() );\r
+                        }\r
+                        n.getNodeData().getTaxonomy().setIdentifier( new Identifier( name ) );\r
+                        break;\r
+                    }\r
+                }\r
+            }\r
+        }\r
+    }\r
+\r
+    static double addPhylogenyDistances( final double a, final double b ) {\r
+        if ( ( a >= 0.0 ) && ( b >= 0.0 ) ) {\r
+            return a + b;\r
+        }\r
+        else if ( a >= 0.0 ) {\r
+            return a;\r
+        }\r
+        else if ( b >= 0.0 ) {\r
+            return b;\r
+        }\r
+        return PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT;\r
+    }\r
+\r
+    static double calculateDistanceToAncestor( final PhylogenyNode anc, PhylogenyNode desc ) {\r
+        double d = 0;\r
+        boolean all_default = true;\r
+        while ( anc != desc ) {\r
+            if ( desc.getDistanceToParent() != PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT ) {\r
+                d += desc.getDistanceToParent();\r
+                if ( all_default ) {\r
+                    all_default = false;\r
+                }\r
+            }\r
+            desc = desc.getParent();\r
+        }\r
+        if ( all_default ) {\r
+            return PhylogenyDataUtil.BRANCH_LENGTH_DEFAULT;\r
+        }\r
+        return d;\r
+    }\r
+\r
+    /**\r
+     * Deep copies the phylogeny originating from this node.\r
+     */\r
+    static PhylogenyNode copySubTree( final PhylogenyNode source ) {\r
+        if ( source == null ) {\r
+            return null;\r
+        }\r
+        else {\r
+            final PhylogenyNode newnode = source.copyNodeData();\r
+            if ( !source.isExternal() ) {\r
+                for( int i = 0; i < source.getNumberOfDescendants(); ++i ) {\r
+                    newnode.setChildNode( i, PhylogenyMethods.copySubTree( source.getChildNode( i ) ) );\r
+                }\r
+            }\r
+            return newnode;\r
+        }\r
+    }\r
+\r
+    /**\r
+     * Shallow copies the phylogeny originating from this node.\r
+     */\r
+    static PhylogenyNode copySubTreeShallow( final PhylogenyNode source ) {\r
+        if ( source == null ) {\r
+            return null;\r
+        }\r
+        else {\r
+            final PhylogenyNode newnode = source.copyNodeDataShallow();\r
+            if ( !source.isExternal() ) {\r
+                for( int i = 0; i < source.getNumberOfDescendants(); ++i ) {\r
+                    newnode.setChildNode( i, PhylogenyMethods.copySubTreeShallow( source.getChildNode( i ) ) );\r
+                }\r
+            }\r
+            return newnode;\r
+        }\r
+    }\r
+\r
+    private final static List<PhylogenyNode> divideIntoSubTreesHelper( final PhylogenyNode node,\r
+                                                                       final double min_distance_to_root ) {\r
+        final List<PhylogenyNode> l = new ArrayList<PhylogenyNode>();\r
+        final PhylogenyNode r = moveTowardsRoot( node, min_distance_to_root );\r
+        for( final PhylogenyNode ext : r.getAllExternalDescendants() ) {\r
+            if ( ext.getIndicator() != 0 ) {\r
+                throw new RuntimeException( "this should not have happened" );\r
+            }\r
+            ext.setIndicator( ( byte ) 1 );\r
+            l.add( ext );\r
+        }\r
+        return l;\r
+    }\r
+\r
+    /**\r
+     * Calculates the distance between PhylogenyNodes n1 and n2.\r
+     * PRECONDITION: n1 is a descendant of n2.\r
+     * \r
+     * @param n1\r
+     *            a descendant of n2\r
+     * @param n2\r
+     * @return distance between n1 and n2\r
+     */\r
+    private static double getDistance( PhylogenyNode n1, final PhylogenyNode n2 ) {\r
+        double d = 0.0;\r
+        while ( n1 != n2 ) {\r
+            if ( n1.getDistanceToParent() > 0.0 ) {\r
+                d += n1.getDistanceToParent();\r
+            }\r
+            n1 = n1.getParent();\r
+        }\r
+        return d;\r
+    }\r
+\r
+    private static boolean match( final String s,\r
+                                  final String query,\r
+                                  final boolean case_sensitive,\r
+                                  final boolean partial ) {\r
+        if ( ForesterUtil.isEmpty( s ) || ForesterUtil.isEmpty( query ) ) {\r
+            return false;\r
+        }\r
+        String my_s = s.trim();\r
+        String my_query = query.trim();\r
+        if ( !case_sensitive ) {\r
+            my_s = my_s.toLowerCase();\r
+            my_query = my_query.toLowerCase();\r
+        }\r
+        if ( partial ) {\r
+            return my_s.indexOf( my_query ) >= 0;\r
+        }\r
+        else {\r
+            return Pattern.compile( "(\\b|_)" + Pattern.quote( my_query ) + "(\\b|_)" ).matcher( my_s ).find();\r
+        }\r
+    }\r
+\r
+    private final static PhylogenyNode moveTowardsRoot( final PhylogenyNode node, final double min_distance_to_root ) {\r
+        PhylogenyNode n = node;\r
+        PhylogenyNode prev = node;\r
+        while ( min_distance_to_root < n.calculateDistanceToRoot() ) {\r
+            prev = n;\r
+            n = n.getParent();\r
+        }\r
+        return prev;\r
+    }\r
+\r
+    public static enum DESCENDANT_SORT_PRIORITY {\r
+        NODE_NAME, SEQUENCE, TAXONOMY;\r
+    }\r
+\r
+    public static enum PhylogenyNodeField {\r
+        CLADE_NAME,\r
+        SEQUENCE_NAME,\r
+        SEQUENCE_SYMBOL,\r
+        TAXONOMY_CODE,\r
+        TAXONOMY_COMMON_NAME,\r
+        TAXONOMY_ID,\r
+        TAXONOMY_ID_UNIPROT_1,\r
+        TAXONOMY_ID_UNIPROT_2,\r
+        TAXONOMY_SCIENTIFIC_NAME;\r
+    }\r
+}\r
index 700d120..41ce1f0 100644 (file)
@@ -27,8 +27,8 @@ package org.forester.util;
 
 public final class ForesterConstants {
 
-    public final static String  FORESTER_VERSION            = "1.033";
-    public final static String  FORESTER_DATE               = "140514";
+    public final static String  FORESTER_VERSION            = "1.034";
+    public final static String  FORESTER_DATE               = "140605";
     public final static String  PHYLO_XML_VERSION           = "1.10";
     public final static String  PHYLO_XML_LOCATION          = "http://www.phyloxml.org";
     public final static String  PHYLO_XML_XSD               = "phyloxml.xsd";