JAL-1264 exclude score-only from 'Add Reference Annotations'
[jalview.git] / src / jalview / gui / AlignFrame.java
index 85e3db5..3f74327 100644 (file)
@@ -54,7 +54,6 @@ import jalview.datamodel.AlignmentOrder;
 import jalview.datamodel.AlignmentView;
 import jalview.datamodel.ColumnSelection;
 import jalview.datamodel.HiddenColumns;
-import jalview.datamodel.HiddenMarkovModel;
 import jalview.datamodel.HiddenSequences;
 import jalview.datamodel.PDBEntry;
 import jalview.datamodel.SeqCigar;
@@ -63,11 +62,12 @@ import jalview.datamodel.SequenceGroup;
 import jalview.datamodel.SequenceI;
 import jalview.gui.ColourMenuHelper.ColourChangeListener;
 import jalview.gui.ViewSelectionMenu.ViewSetProvider;
-import jalview.hmmer.HMMAlignThread;
-import jalview.hmmer.HMMBuildThread;
+import jalview.hmmer.HMMAlign;
+import jalview.hmmer.HMMBuild;
 import jalview.hmmer.HMMERParamStore;
 import jalview.hmmer.HMMERPreset;
-import jalview.hmmer.HMMSearchThread;
+import jalview.hmmer.HMMSearch;
+import jalview.hmmer.HmmerCommand;
 import jalview.io.AlignmentProperties;
 import jalview.io.AnnotationFile;
 import jalview.io.BioJsHTMLOutput;
@@ -87,6 +87,7 @@ import jalview.io.JnetAnnotationMaker;
 import jalview.io.NewickFile;
 import jalview.io.ScoreMatrixFile;
 import jalview.io.TCoffeeScoreFile;
+import jalview.io.vcf.VCFLoader;
 import jalview.jbgui.GAlignFrame;
 import jalview.schemes.ColourSchemeI;
 import jalview.schemes.ColourSchemes;
@@ -138,16 +139,14 @@ import java.net.URL;
 import java.util.ArrayList;
 import java.util.Arrays;
 import java.util.Deque;
-import java.util.Enumeration;
-import java.util.HashMap;
-import java.util.Hashtable;
+import java.util.HashSet;
 import java.util.List;
-import java.util.Map;
+import java.util.Set;
 import java.util.Vector;
 
 import javax.swing.JCheckBoxMenuItem;
 import javax.swing.JEditorPane;
-import javax.swing.JFrame;
+import javax.swing.JFileChooser;
 import javax.swing.JInternalFrame;
 import javax.swing.JLayeredPane;
 import javax.swing.JMenu;
@@ -165,16 +164,10 @@ import javax.swing.SwingUtilities;
 public class AlignFrame extends GAlignFrame implements DropTargetListener,
         IProgressIndicator, AlignViewControllerGuiI, ColourChangeListener
 {
-
-  Map<String, Float> distribution = new HashMap<>(); // temporary
-
   public static final int DEFAULT_WIDTH = 700;
 
   public static final int DEFAULT_HEIGHT = 500;
 
-  boolean autoAlignNewSequences;
-
-
   /*
    * The currently displayed panel (selected tabbed view if more than one)
    */
@@ -182,13 +175,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
 
   AlignViewport viewport;
 
-  ViewportRanges vpRanges;
-
   public AlignViewControllerI avc;
-  /*
-   * The selected HMM for this align frame
-   */
-  SequenceI selectedHMMSequence;
 
   List<AlignmentPanel> alignPanels = new ArrayList<>();
 
@@ -360,7 +347,6 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       progressBar = new ProgressBar(this.statusPanel, this.statusBar);
     }
 
-    vpRanges = viewport.getRanges();
     avc = new jalview.controller.AlignViewController(this, viewport,
             alignPanel);
     if (viewport.getAlignmentConservationAnnotation() == null)
@@ -400,7 +386,6 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       }
     });
     buildColourMenu();
-    buildHMMERMenu();
 
     if (Desktop.desktop != null)
     {
@@ -508,18 +493,6 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   }
 
   /**
-   * Adds all menu items to the HMMER menu
-   */
-  private void buildHMMERMenu()
-  {
-    hmmerMenu.removeAll();
-
-    hmmerMenu.add(hmmAlign);
-    hmmerMenu.add(hmmBuild);
-    hmmerMenu.add(hmmSearch);
-  }
-
-  /**
    * Change the filename and format for the alignment, and enable the 'reload'
    * button functionality.
    * 
@@ -691,9 +664,10 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
                   { (viewport.cursorMode ? "on" : "off") }));
           if (viewport.cursorMode)
           {
-            alignPanel.getSeqPanel().seqCanvas.cursorX = vpRanges
+            ViewportRanges ranges = viewport.getRanges();
+            alignPanel.getSeqPanel().seqCanvas.cursorX = ranges
                     .getStartRes();
-            alignPanel.getSeqPanel().seqCanvas.cursorY = vpRanges
+            alignPanel.getSeqPanel().seqCanvas.cursorY = ranges
                     .getStartSeq();
           }
           alignPanel.getSeqPanel().seqCanvas.repaint();
@@ -726,10 +700,10 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
           break;
         }
         case KeyEvent.VK_PAGE_UP:
-          vpRanges.pageUp();
+          viewport.getRanges().pageUp();
           break;
         case KeyEvent.VK_PAGE_DOWN:
-          vpRanges.pageDown();
+          viewport.getRanges().pageDown();
           break;
         }
       }
@@ -800,7 +774,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       ap.av.updateConservation(ap);
       ap.av.updateConsensus(ap);
       ap.av.updateStrucConsensus(ap);
-      ap.av.updateInformation(ap);
+      ap.av.initInformationWorker(ap);
     }
   }
 
@@ -879,6 +853,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     AlignmentI al = getViewport().getAlignment();
     boolean nucleotide = al.isNucleotide();
 
+    loadVcf.setVisible(nucleotide);
     showTranslation.setVisible(nucleotide);
     showReverse.setVisible(nucleotide);
     showReverseComplement.setVisible(nucleotide);
@@ -1036,110 +1011,111 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   }
 
   @Override
-  public void hmmBuildSettings_actionPerformed(ActionEvent e)
-          throws IOException, InterruptedException
+  public void hmmBuild_actionPerformed(boolean withDefaults)
   {
-    if (!(alignmentIsSufficient(1)))
+    if (!alignmentIsSufficient(1))
     {
       return;
     }
-    WsParamSetI set = new HMMERPreset();
-    List<ArgumentI> args = new ArrayList<>();
-    ParamDatastoreI store = new HMMERParamStore("hmmalign");
-    WsJobParameters params = new WsJobParameters(new JFrame(), store, set,
-            args);
-    params.showRunDialog();
-    new Thread(new HMMBuildThread(this, params.getJobParams())).start();
-    alignPanel.repaint();
 
-  }
+    /*
+     * get default parameters, and optionally show a dialog
+     * to allow them to be modified
+     */
+    ParamDatastoreI store = HMMERParamStore.forBuild(viewport);
+    List<ArgumentI> args = store.getServiceParameters();
 
-  @Override
-  public void hmmAlignSettings_actionPerformed(ActionEvent e)
-          throws IOException, InterruptedException
-  {
-    if (!(checkForHMM() && alignmentIsSufficient(2)))
+    if (!withDefaults)
     {
-      return;
+      WsParamSetI set = new HMMERPreset();
+      WsJobParameters params = new WsJobParameters(store, set, args);
+      if (params.showRunDialog())
+      {
+        args = params.getJobParams();
+      }
+      else
+      {
+        return; // user cancelled
+      }
     }
-    WsParamSetI set = new HMMERPreset();
-    List<ArgumentI> args = new ArrayList<>();
-    ParamDatastoreI store = new HMMERParamStore("hmmalign");
-    WsJobParameters params = new WsJobParameters(new JFrame(), store, set,
-            args);
-    params.showRunDialog();
-    new Thread(new HMMAlignThread(this, true, params.getJobParams()))
-            .start();
-    alignPanel.repaint();
+    new Thread(new HMMBuild(this, args)).start();
   }
 
   @Override
-  public void hmmSearchSettings_actionPerformed(ActionEvent e)
+  public void hmmAlign_actionPerformed(boolean withDefaults)
   {
-    if (!checkForHMM())
+    if (!(checkForHMM() && alignmentIsSufficient(2)))
     {
       return;
     }
-    WsParamSetI set = new HMMERPreset();
-    List<ArgumentI> args = new ArrayList<>();
-    ParamDatastoreI store = new HMMERParamStore("hmmsearch");
-    WsJobParameters params = new WsJobParameters(new JFrame(), store, set,
-            args);
-    params.showRunDialog();
-    new Thread(new HMMSearchThread(this, true, params.getJobParams()))
-            .start();
-    alignPanel.repaint();
-  }
 
-  @Override
-  public void hmmBuildRun_actionPerformed(ActionEvent e)
-          throws IOException, InterruptedException
-  {
-    if (!alignmentIsSufficient(1))
+    /*
+     * get default parameters, and optionally show a dialog
+     * to allow them to be modified
+     */
+    ParamDatastoreI store = HMMERParamStore.forAlign(viewport);
+    List<ArgumentI> args = store.getServiceParameters();
+
+    if (!withDefaults)
     {
-      return;
+      WsParamSetI set = new HMMERPreset();
+      WsJobParameters params = new WsJobParameters(store, set, args);
+      if (params.showRunDialog())
+      {
+        args = params.getJobParams();
+      }
+      else
+      {
+        return; // user cancelled
+      }
     }
-    new Thread(new HMMBuildThread(this, null)).start();
-    alignPanel.repaint();
-
+    new Thread(new HMMAlign(this, args)).start();
   }
 
   @Override
-  public void hmmAlignRun_actionPerformed(ActionEvent e)
-          throws IOException, InterruptedException
+  public void hmmSearch_actionPerformed(boolean withDefaults)
   {
-    if (!(checkForHMM() && alignmentIsSufficient(2)))
+    if (!checkForHMM())
     {
       return;
     }
-    new Thread(new HMMAlignThread(this, true, null))
-            .start();
-    alignPanel.repaint();
-  }
 
-  @Override
-  public void hmmSearchRun_actionPerformed(ActionEvent e)
-  {
-    if (!checkForHMM())
+    /*
+     * get default parameters, and (if requested) show 
+     * dialog to allow modification
+     */
+    ParamDatastoreI store = HMMERParamStore.forSearch(viewport);
+    List<ArgumentI> args = store.getServiceParameters();
+
+    if (!withDefaults)
     {
-      return;
+      WsParamSetI set = new HMMERPreset();
+      WsJobParameters params = new WsJobParameters(store, set, args);
+      if (params.showRunDialog())
+      {
+        args = params.getJobParams();
+      }
+      else
+      {
+        return; // user cancelled
+      }
     }
-    new Thread(new HMMSearchThread(this, true, null))
-            .start();
+    new Thread(new HMMSearch(this, args)).start();
     alignPanel.repaint();
   }
 
   /**
-   * Checks if the frame has a selected hidden Markov model
+   * Checks if the alignment has at least one hidden Markov model, if not shows
+   * a dialog advising to run hmmbuild or load an HMM profile
    * 
    * @return
    */
   private boolean checkForHMM()
   {
-    if (getSelectedHMM() == null)
+    if (viewport.getAlignment().getHmmSequences().isEmpty())
     {
       JOptionPane.showMessageDialog(this,
-              MessageManager.getString("warn.no_selected_hmm"));
+              MessageManager.getString("warn.no_hmm"));
       return false;
     }
     return true;
@@ -1156,12 +1132,76 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     if (getViewport().getAlignment().getSequences().size() < required)
     {
       JOptionPane.showMessageDialog(this,
-              MessageManager.getString("warn.not_enough_sequences"));
+              MessageManager.getString("label.not_enough_sequences"));
       return false;
     }
     return true;
   }
 
+  /**
+   * Opens a file browser and adds the selected file, if in Fasta, Stockholm or
+   * Pfam format, to the list held under preference key "HMMSEARCH_DBS" (as a
+   * comma-separated list)
+   */
+  @Override
+  public void addDatabase_actionPerformed() throws IOException
+  {
+    if (Cache.getProperty(Preferences.HMMSEARCH_DBS) == null)
+    {
+      Cache.setProperty(Preferences.HMMSEARCH_DBS, "");
+    }
+
+    String path = openFileChooser(false);
+    if (path != null && new File(path).exists())
+    {
+      IdentifyFile identifier = new IdentifyFile();
+      FileFormatI format = identifier.identify(path, DataSourceType.FILE);
+      if (format == FileFormat.Fasta || format == FileFormat.Stockholm
+              || format == FileFormat.Pfam)
+      {
+        String currentDbPaths = Cache
+                .getProperty(Preferences.HMMSEARCH_DBS);
+        currentDbPaths += Preferences.COMMA + path;
+        Cache.setProperty(Preferences.HMMSEARCH_DBS, currentDbPaths);
+      }
+      else
+      {
+        JOptionPane.showMessageDialog(this,
+                MessageManager.getString("warn.invalid_format"));
+      }
+    }
+  }
+
+  /**
+   * Opens a file chooser, optionally restricted to selecting folders
+   * (directories) only. Answers the path to the selected file or folder, or
+   * null if none is chosen.
+   * 
+   * @param
+   * @return
+   */
+  protected String openFileChooser(boolean forFolder)
+  {
+    // TODO duplicates GPreferences method - relocate to JalviewFileChooser?
+    String choice = null;
+    JFileChooser chooser = new JFileChooser();
+    if (forFolder)
+    {
+      chooser.setFileSelectionMode(JFileChooser.DIRECTORIES_ONLY);
+    }
+    chooser.setDialogTitle(
+            MessageManager.getString("label.open_local_file"));
+    chooser.setToolTipText(MessageManager.getString("action.open"));
+
+    int value = chooser.showOpenDialog(this);
+
+    if (value == JFileChooser.APPROVE_OPTION)
+    {
+      choice = chooser.getSelectedFile().getPath();
+    }
+    return choice;
+  }
+
   @Override
   public void reload_actionPerformed(ActionEvent e)
   {
@@ -1560,13 +1600,13 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   @Override
   public void exportFeatures_actionPerformed(ActionEvent e)
   {
-    new AnnotationExporter().exportFeatures(alignPanel);
+    new AnnotationExporter(alignPanel).exportFeatures();
   }
 
   @Override
   public void exportAnnotations_actionPerformed(ActionEvent e)
   {
-    new AnnotationExporter().exportAnnotations(alignPanel);
+    new AnnotationExporter(alignPanel).exportAnnotations();
   }
 
   @Override
@@ -1880,7 +1920,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     }
     viewport.getAlignment().moveSelectedSequencesByOne(sg,
             viewport.getHiddenRepSequences(), up);
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   synchronized void slideSequences(boolean right, int size)
@@ -1997,7 +2037,6 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   @Override
   protected void copy_actionPerformed(ActionEvent e)
   {
-    System.gc();
     if (viewport.getSelectionGroup() == null)
     {
       return;
@@ -2033,25 +2072,17 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       return;
     }
 
-    ArrayList<int[]> hiddenColumns = null;
+    HiddenColumns hiddenColumns = null;
     if (viewport.hasHiddenColumns())
     {
-      hiddenColumns = new ArrayList<>();
-
       int hiddenOffset = viewport.getSelectionGroup().getStartRes();
       int hiddenCutoff = viewport.getSelectionGroup().getEndRes();
-      ArrayList<int[]> hiddenRegions = viewport.getAlignment()
-              .getHiddenColumns().getHiddenColumnsCopy();
-      for (int[] region : hiddenRegions)
 
-      {
-        if (region[0] >= hiddenOffset && region[1] <= hiddenCutoff)
-        {
-          hiddenColumns
-                  .add(new int[]
-                  { region[0] - hiddenOffset, region[1] - hiddenOffset });
-        }
-      }
+      // create new HiddenColumns object with copy of hidden regions
+      // between startRes and endRes, offset by startRes
+      hiddenColumns = new HiddenColumns(
+              viewport.getAlignment().getHiddenColumns(), hiddenOffset,
+              hiddenCutoff, hiddenOffset);
     }
 
     Desktop.jalviewClipboard = new Object[] { seqs,
@@ -2326,7 +2357,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       {
 
         // propagate alignment changed.
-        vpRanges.setEndSeq(alignment.getHeight());
+        viewport.getRanges().setEndSeq(alignment.getHeight());
         if (annotationAdded)
         {
           // Duplicate sequence annotation in all views.
@@ -2388,11 +2419,8 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
         if (Desktop.jalviewClipboard != null
                 && Desktop.jalviewClipboard[2] != null)
         {
-          List<int[]> hc = (List<int[]>) Desktop.jalviewClipboard[2];
-          for (int[] region : hc)
-          {
-            af.viewport.hideColumns(region[0], region[1]);
-          }
+          HiddenColumns hc = (HiddenColumns) Desktop.jalviewClipboard[2];
+          af.viewport.setHiddenColumns(hc);
         }
 
         // >>>This is a fix for the moment, until a better solution is
@@ -2446,11 +2474,8 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       if (Desktop.jalviewClipboard != null
               && Desktop.jalviewClipboard[2] != null)
       {
-        List<int[]> hc = (List<int[]>) Desktop.jalviewClipboard[2];
-        for (int region[] : hc)
-        {
-          af.viewport.hideColumns(region[0], region[1]);
-        }
+        HiddenColumns hc = (HiddenColumns) Desktop.jalviewClipboard[2];
+        af.viewport.setHiddenColumns(hc);
       }
 
       // >>>This is a fix for the moment, until a better solution is
@@ -2575,7 +2600,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     {
       PaintRefresher.Refresh(this, viewport.getSequenceSetId());
       alignPanel.updateAnnotation();
-      alignPanel.paintAlignment(true);
+      alignPanel.paintAlignment(true, true);
     }
   }
 
@@ -2601,7 +2626,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     // JAL-2034 - should delegate to
     // alignPanel to decide if overview needs
     // updating.
-    alignPanel.paintAlignment(false);
+    alignPanel.paintAlignment(false, false);
     PaintRefresher.Refresh(alignPanel, viewport.getSequenceSetId());
   }
 
@@ -2622,12 +2647,11 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     viewport.setSelectionGroup(null);
     viewport.getColumnSelection().clear();
     viewport.setSelectionGroup(null);
-    alignPanel.getSeqPanel().seqCanvas.highlightSearchResults(null);
     alignPanel.getIdPanel().getIdCanvas().searchResults = null;
     // JAL-2034 - should delegate to
     // alignPanel to decide if overview needs
     // updating.
-    alignPanel.paintAlignment(false);
+    alignPanel.paintAlignment(false, false);
     PaintRefresher.Refresh(alignPanel, viewport.getSequenceSetId());
     viewport.sendSelection();
   }
@@ -2658,7 +2682,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     // alignPanel to decide if overview needs
     // updating.
 
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
     PaintRefresher.Refresh(alignPanel, viewport.getSequenceSetId());
     viewport.sendSelection();
   }
@@ -2667,7 +2691,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void invertColSel_actionPerformed(ActionEvent e)
   {
     viewport.invertColumnSelection();
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
     viewport.sendSelection();
   }
 
@@ -2727,7 +2751,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       {
         trimRegion = new TrimRegionCommand("Remove Left", true, seqs,
                 column, viewport.getAlignment());
-        vpRanges.setStartRes(0);
+        viewport.getRanges().setStartRes(0);
       }
       else
       {
@@ -2792,13 +2816,14 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     // This is to maintain viewport position on first residue
     // of first sequence
     SequenceI seq = viewport.getAlignment().getSequenceAt(0);
-    int startRes = seq.findPosition(vpRanges.getStartRes());
+    ViewportRanges ranges = viewport.getRanges();
+    int startRes = seq.findPosition(ranges.getStartRes());
     // ShiftList shifts;
     // viewport.getAlignment().removeGaps(shifts=new ShiftList());
     // edit.alColumnChanges=shifts.getInverse();
     // if (viewport.hasHiddenColumns)
     // viewport.getColumnSelection().compensateForEdits(shifts);
-    vpRanges.setStartRes(seq.findIndex(startRes) - 1);
+    ranges.setStartRes(seq.findIndex(startRes) - 1);
     viewport.firePropertyChange("alignment", null,
             viewport.getAlignment().getSequences());
 
@@ -2831,12 +2856,12 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     // This is to maintain viewport position on first residue
     // of first sequence
     SequenceI seq = viewport.getAlignment().getSequenceAt(0);
-    int startRes = seq.findPosition(vpRanges.getStartRes());
+    int startRes = seq.findPosition(viewport.getRanges().getStartRes());
 
     addHistoryItem(new RemoveGapsCommand("Remove Gaps", seqs, start, end,
             viewport.getAlignment()));
 
-    vpRanges.setStartRes(seq.findIndex(startRes) - 1);
+    viewport.getRanges().setStartRes(seq.findIndex(startRes) - 1);
 
     viewport.firePropertyChange("alignment", null,
             viewport.getAlignment().getSequences());
@@ -2892,8 +2917,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     /*
      * Create a new AlignmentPanel (with its own, new Viewport)
      */
-    AlignmentPanel newap = new Jalview2XML().copyAlignPanel(alignPanel,
-            true);
+    AlignmentPanel newap = new Jalview2XML().copyAlignPanel(alignPanel);
     if (!copyAnnotation)
     {
       /*
@@ -3047,21 +3071,21 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
 
     alignPanel.getIdPanel().getIdCanvas()
             .setPreferredSize(alignPanel.calculateIdWidth());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   @Override
   public void idRightAlign_actionPerformed(ActionEvent e)
   {
     viewport.setRightAlignIds(idRightAlign.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   @Override
   public void centreColumnLabels_actionPerformed(ActionEvent e)
   {
     viewport.setCentreColumnLabels(centreColumnLabelsMenuItem.getState());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /*
@@ -3094,7 +3118,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void colourTextMenuItem_actionPerformed(ActionEvent e)
   {
     viewport.setColourText(colourTextMenuItem.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /**
@@ -3123,7 +3147,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void showAllColumns_actionPerformed(ActionEvent e)
   {
     viewport.showAllHiddenColumns();
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
     viewport.sendSelection();
   }
 
@@ -3227,7 +3251,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     viewport.expandColSelection(sg, false);
     viewport.hideAllSelectedSeqs();
     viewport.hideSelectedColumns();
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
     viewport.sendSelection();
   }
 
@@ -3243,7 +3267,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   {
     viewport.showAllHiddenColumns();
     viewport.showAllHiddenSeqs();
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
     viewport.sendSelection();
   }
 
@@ -3251,7 +3275,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void hideSelColumns_actionPerformed(ActionEvent e)
   {
     viewport.hideSelectedColumns();
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
     viewport.sendSelection();
   }
 
@@ -3272,7 +3296,8 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void scaleAbove_actionPerformed(ActionEvent e)
   {
     viewport.setScaleAboveWrapped(scaleAbove.isSelected());
-    alignPanel.paintAlignment(true);
+    // TODO: do we actually need to update overview for scale above change ?
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3285,7 +3310,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void scaleLeft_actionPerformed(ActionEvent e)
   {
     viewport.setScaleLeftWrapped(scaleLeft.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3298,7 +3323,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void scaleRight_actionPerformed(ActionEvent e)
   {
     viewport.setScaleRightWrapped(scaleRight.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3311,7 +3336,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void viewBoxesMenuItem_actionPerformed(ActionEvent e)
   {
     viewport.setShowBoxes(viewBoxesMenuItem.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /**
@@ -3324,7 +3349,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void viewTextMenuItem_actionPerformed(ActionEvent e)
   {
     viewport.setShowText(viewTextMenuItem.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /**
@@ -3337,7 +3362,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void renderGapsMenuItem_actionPerformed(ActionEvent e)
   {
     viewport.setRenderGaps(renderGapsMenuItem.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   public FeatureSettings featureSettings;
@@ -3375,7 +3400,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   public void showSeqFeatures_actionPerformed(ActionEvent evt)
   {
     viewport.setShowSequenceFeatures(showSeqFeatures.isSelected());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
   }
 
   /**
@@ -3532,7 +3557,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
 
     viewport.setGlobalColourScheme(cs);
 
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, true);
   }
 
   /**
@@ -3617,7 +3642,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
             viewport.getAlignment().getSequenceAt(0));
     addHistoryItem(new OrderCommand("Pairwise Sort", oldOrder,
             viewport.getAlignment()));
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3633,7 +3658,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     AlignmentSorter.sortByID(viewport.getAlignment());
     addHistoryItem(
             new OrderCommand("ID Sort", oldOrder, viewport.getAlignment()));
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3649,7 +3674,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     AlignmentSorter.sortByLength(viewport.getAlignment());
     addHistoryItem(new OrderCommand("Length Sort", oldOrder,
             viewport.getAlignment()));
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3666,7 +3691,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     addHistoryItem(new OrderCommand("Group Sort", oldOrder,
             viewport.getAlignment()));
 
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
   }
 
   /**
@@ -3823,7 +3848,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
         addHistoryItem(new OrderCommand(order.getName(), oldOrder,
                 viewport.getAlignment()));
 
-        alignPanel.paintAlignment(true);
+        alignPanel.paintAlignment(true, false);
       }
     });
   }
@@ -3852,7 +3877,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
                 viewport.getAlignment());// ,viewport.getSelectionGroup());
         addHistoryItem(new OrderCommand("Sort by " + scoreLabel, oldOrder,
                 viewport.getAlignment()));
-        alignPanel.paintAlignment(true);
+        alignPanel.paintAlignment(true, false);
       }
     });
   }
@@ -3878,35 +3903,33 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     }
 
     if (viewport.getAlignment().getAlignmentAnnotation()
-            .hashCode() != _annotationScoreVectorHash)
+            .hashCode() == _annotationScoreVectorHash)
     {
-      sortByAnnotScore.removeAll();
-      // almost certainly a quicker way to do this - but we keep it simple
-      Hashtable scoreSorts = new Hashtable();
-      AlignmentAnnotation aann[];
-      for (SequenceI sqa : viewport.getAlignment().getSequences())
+      return;
+    }
+
+    sortByAnnotScore.removeAll();
+    Set<String> scoreSorts = new HashSet<>();
+    for (SequenceI sqa : viewport.getAlignment().getSequences())
+    {
+      AlignmentAnnotation[] anns = sqa.getAnnotation();
+      for (int i = 0; anns != null && i < anns.length; i++)
       {
-        aann = sqa.getAnnotation();
-        for (int i = 0; aann != null && i < aann.length; i++)
+        AlignmentAnnotation aa = anns[i];
+        if (aa != null && aa.hasScore() && aa.sequenceRef != null)
         {
-          if (aann[i].hasScore() && aann[i].sequenceRef != null)
-          {
-            scoreSorts.put(aann[i].label, aann[i].label);
-          }
+          scoreSorts.add(aa.label);
         }
       }
-      Enumeration labels = scoreSorts.keys();
-      while (labels.hasMoreElements())
-      {
-        addSortByAnnotScoreMenuItem(sortByAnnotScore,
-                (String) labels.nextElement());
-      }
-      sortByAnnotScore.setVisible(scoreSorts.size() > 0);
-      scoreSorts.clear();
-
-      _annotationScoreVectorHash = viewport.getAlignment()
-              .getAlignmentAnnotation().hashCode();
     }
+    for (String label : scoreSorts)
+    {
+      addSortByAnnotScoreMenuItem(sortByAnnotScore, label);
+    }
+    sortByAnnotScore.setVisible(!scoreSorts.isEmpty());
+
+    _annotationScoreVectorHash = viewport.getAlignment()
+            .getAlignmentAnnotation().hashCode();
   }
 
   /**
@@ -3967,7 +3990,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       addHistoryItem(new OrderCommand(undoname, oldOrder,
               viewport.getAlignment()));
     }
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(true, false);
     return true;
   }
 
@@ -4438,7 +4461,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void showProductsFor(final SequenceI[] sel, final boolean _odna,
           final String source)
   {
-    new Thread(CrossRefAction.showProductsFor(sel, _odna, source, this))
+    new Thread(CrossRefAction.getHandlerFor(sel, _odna, source, this))
             .start();
   }
 
@@ -4565,7 +4588,8 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     // Java's Transferable for native dnd
     evt.acceptDrop(DnDConstants.ACTION_COPY_OR_MOVE);
     Transferable t = evt.getTransferable();
-    List<String> files = new ArrayList<>();
+    final AlignFrame thisaf = this;
+    final List<String> files = new ArrayList<>();
     List<DataSourceType> protocols = new ArrayList<>();
 
     try
@@ -4577,133 +4601,146 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     }
     if (files != null)
     {
-      try
+      new Thread(new Runnable()
       {
-        // check to see if any of these files have names matching sequences in
-        // the alignment
-        SequenceIdMatcher idm = new SequenceIdMatcher(
-                viewport.getAlignment().getSequencesArray());
-        /**
-         * Object[] { String,SequenceI}
-         */
-        ArrayList<Object[]> filesmatched = new ArrayList<>();
-        ArrayList<String> filesnotmatched = new ArrayList<>();
-        for (int i = 0; i < files.size(); i++)
+        @Override
+        public void run()
         {
-          String file = files.get(i).toString();
-          String pdbfn = "";
-          DataSourceType protocol = FormatAdapter.checkProtocol(file);
-          if (protocol == DataSourceType.FILE)
-          {
-            File fl = new File(file);
-            pdbfn = fl.getName();
-          }
-          else if (protocol == DataSourceType.URL)
-          {
-            URL url = new URL(file);
-            pdbfn = url.getFile();
-          }
-          if (pdbfn.length() > 0)
+          try
           {
-            // attempt to find a match in the alignment
-            SequenceI[] mtch = idm.findAllIdMatches(pdbfn);
-            int l = 0, c = pdbfn.indexOf(".");
-            while (mtch == null && c != -1)
+            // check to see if any of these files have names matching sequences
+            // in
+            // the alignment
+            SequenceIdMatcher idm = new SequenceIdMatcher(
+                    viewport.getAlignment().getSequencesArray());
+            /**
+             * Object[] { String,SequenceI}
+             */
+            ArrayList<Object[]> filesmatched = new ArrayList<>();
+            ArrayList<String> filesnotmatched = new ArrayList<>();
+            for (int i = 0; i < files.size(); i++)
             {
-              do
+              String file = files.get(i).toString();
+              String pdbfn = "";
+              DataSourceType protocol = FormatAdapter.checkProtocol(file);
+              if (protocol == DataSourceType.FILE)
               {
-                l = c;
-              } while ((c = pdbfn.indexOf(".", l)) > l);
-              if (l > -1)
-              {
-                pdbfn = pdbfn.substring(0, l);
+                File fl = new File(file);
+                pdbfn = fl.getName();
               }
-              mtch = idm.findAllIdMatches(pdbfn);
-            }
-            if (mtch != null)
-            {
-              FileFormatI type = null;
-              try
+              else if (protocol == DataSourceType.URL)
               {
-                type = new IdentifyFile().identify(file, protocol);
-              } catch (Exception ex)
-              {
-                type = null;
+                URL url = new URL(file);
+                pdbfn = url.getFile();
               }
-              if (type != null && type.isStructureFile())
+              if (pdbfn.length() > 0)
               {
-                filesmatched.add(new Object[] { file, protocol, mtch });
-                continue;
+                // attempt to find a match in the alignment
+                SequenceI[] mtch = idm.findAllIdMatches(pdbfn);
+                int l = 0, c = pdbfn.indexOf(".");
+                while (mtch == null && c != -1)
+                {
+                  do
+                  {
+                    l = c;
+                  } while ((c = pdbfn.indexOf(".", l)) > l);
+                  if (l > -1)
+                  {
+                    pdbfn = pdbfn.substring(0, l);
+                  }
+                  mtch = idm.findAllIdMatches(pdbfn);
+                }
+                if (mtch != null)
+                {
+                  FileFormatI type = null;
+                  try
+                  {
+                    type = new IdentifyFile().identify(file, protocol);
+                  } catch (Exception ex)
+                  {
+                    type = null;
+                  }
+                  if (type != null && type.isStructureFile())
+                  {
+                    filesmatched.add(new Object[] { file, protocol, mtch });
+                    continue;
+                  }
+                }
+                // File wasn't named like one of the sequences or wasn't a PDB
+                // file.
+                filesnotmatched.add(file);
               }
             }
-            // File wasn't named like one of the sequences or wasn't a PDB file.
-            filesnotmatched.add(file);
-          }
-        }
-        int assocfiles = 0;
-        if (filesmatched.size() > 0)
-        {
-          if (Cache.getDefault("AUTOASSOCIATE_PDBANDSEQS", false)
-                  || JvOptionPane.showConfirmDialog(this,
-                          MessageManager.formatMessage(
-                                  "label.automatically_associate_structure_files_with_sequences_same_name",
-                                  new Object[]
-                                  { Integer.valueOf(filesmatched.size())
-                                          .toString() }),
-                          MessageManager.getString(
-                                  "label.automatically_associate_structure_files_by_name"),
-                          JvOptionPane.YES_NO_OPTION) == JvOptionPane.YES_OPTION)
-
-          {
-            for (Object[] fm : filesmatched)
+            int assocfiles = 0;
+            if (filesmatched.size() > 0)
             {
-              // try and associate
-              // TODO: may want to set a standard ID naming formalism for
-              // associating PDB files which have no IDs.
-              for (SequenceI toassoc : (SequenceI[]) fm[2])
+              if (Cache.getDefault("AUTOASSOCIATE_PDBANDSEQS", false)
+                      || JvOptionPane.showConfirmDialog(thisaf,
+                              MessageManager.formatMessage(
+                                      "label.automatically_associate_structure_files_with_sequences_same_name",
+                                      new Object[]
+                                      { Integer.valueOf(filesmatched.size())
+                                              .toString() }),
+                              MessageManager.getString(
+                                      "label.automatically_associate_structure_files_by_name"),
+                              JvOptionPane.YES_NO_OPTION) == JvOptionPane.YES_OPTION)
+
               {
-                PDBEntry pe = new AssociatePdbFileWithSeq()
-                        .associatePdbWithSeq((String) fm[0],
-                                (DataSourceType) fm[1], toassoc, false,
-                                Desktop.instance);
-                if (pe != null)
+                for (Object[] fm : filesmatched)
                 {
-                  System.err.println("Associated file : " + ((String) fm[0])
-                          + " with " + toassoc.getDisplayId(true));
-                  assocfiles++;
+                  // try and associate
+                  // TODO: may want to set a standard ID naming formalism for
+                  // associating PDB files which have no IDs.
+                  for (SequenceI toassoc : (SequenceI[]) fm[2])
+                  {
+                    PDBEntry pe = new AssociatePdbFileWithSeq()
+                            .associatePdbWithSeq((String) fm[0],
+                                    (DataSourceType) fm[1], toassoc, false,
+                                    Desktop.instance);
+                    if (pe != null)
+                    {
+                      System.err.println("Associated file : "
+                              + ((String) fm[0]) + " with "
+                              + toassoc.getDisplayId(true));
+                      assocfiles++;
+                    }
+                  }
+                  // TODO: do we need to update overview ? only if features are
+                  // shown I guess
+                  alignPanel.paintAlignment(true, false);
                 }
               }
-              alignPanel.paintAlignment(true);
             }
-          }
-        }
-        if (filesnotmatched.size() > 0)
-        {
-          if (assocfiles > 0 && (Cache.getDefault(
-                  "AUTOASSOCIATE_PDBANDSEQS_IGNOREOTHERS", false)
-                  || JvOptionPane.showConfirmDialog(this,
-                          "<html>" + MessageManager.formatMessage(
-                                  "label.ignore_unmatched_dropped_files_info",
-                                  new Object[]
-                                  { Integer.valueOf(filesnotmatched.size())
-                                          .toString() })
-                                  + "</html>",
-                          MessageManager.getString(
-                                  "label.ignore_unmatched_dropped_files"),
-                          JvOptionPane.YES_NO_OPTION) == JvOptionPane.YES_OPTION))
-          {
-            return;
-          }
-          for (String fn : filesnotmatched)
+            if (filesnotmatched.size() > 0)
+            {
+              if (assocfiles > 0 && (Cache.getDefault(
+                      "AUTOASSOCIATE_PDBANDSEQS_IGNOREOTHERS", false)
+                      || JvOptionPane.showConfirmDialog(thisaf,
+                              "<html>" + MessageManager.formatMessage(
+                                      "label.ignore_unmatched_dropped_files_info",
+                                      new Object[]
+                                      { Integer.valueOf(
+                                              filesnotmatched.size())
+                                              .toString() })
+                                      + "</html>",
+                              MessageManager.getString(
+                                      "label.ignore_unmatched_dropped_files"),
+                              JvOptionPane.YES_NO_OPTION) == JvOptionPane.YES_OPTION))
+              {
+                return;
+              }
+              for (String fn : filesnotmatched)
+              {
+                loadJalviewDataFile(fn, null, null, null);
+              }
+
+            }
+          } catch (Exception ex)
           {
-            loadJalviewDataFile(fn, null, null, null);
+            ex.printStackTrace();
           }
-
         }
-      } catch (Exception ex)
-      {
-        ex.printStackTrace();
-      }
+      }).start();
     }
   }
 
@@ -4807,11 +4844,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
             new JnetAnnotationMaker();
             JnetAnnotationMaker.add_annotation(predictions,
                     viewport.getAlignment(), 0, false);
-            SequenceI repseq = viewport.getAlignment().getSequenceAt(0);
-            viewport.getAlignment().setSeqrep(repseq);
-            HiddenColumns cs = new HiddenColumns();
-            cs.hideInsertionsFor(repseq);
-            viewport.getAlignment().setHiddenColumns(cs);
+            viewport.getAlignment().setupJPredAlignment();
             isAnnotation = true;
           }
           // else if (IdentifyFile.FeaturesFile.equals(format))
@@ -4819,7 +4852,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
           {
             if (parseFeaturesFile(file, sourceType))
             {
-              alignPanel.paintAlignment(true);
+              alignPanel.paintAlignment(true, true);
             }
           }
           else
@@ -4833,7 +4866,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
         alignPanel.adjustAnnotationHeight();
         viewport.updateSequenceIdColours();
         buildSortByAnnotationScoresMenu();
-        alignPanel.paintAlignment(true);
+        alignPanel.paintAlignment(true, true);
       }
     } catch (Exception ex)
     {
@@ -5032,14 +5065,15 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
             MessageManager.getString("option.trim_retrieved_seqs"));
     trimrs.setToolTipText(
             MessageManager.getString("label.trim_retrieved_sequences"));
-    trimrs.setSelected(Cache.getDefault("TRIM_FETCHED_DATASET_SEQS", true));
+    trimrs.setSelected(
+            Cache.getDefault(DBRefFetcher.TRIM_RETRIEVED_SEQUENCES, true));
     trimrs.addActionListener(new ActionListener()
     {
       @Override
       public void actionPerformed(ActionEvent e)
       {
         trimrs.setSelected(trimrs.isSelected());
-        Cache.setProperty("TRIM_FETCHED_DATASET_SEQS",
+        Cache.setProperty(DBRefFetcher.TRIM_RETRIEVED_SEQUENCES,
                 Boolean.valueOf(trimrs.isSelected()).toString());
       };
     });
@@ -5358,7 +5392,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   protected void showUnconservedMenuItem_actionPerformed(ActionEvent e)
   {
     viewport.setShowUnconserved(showNonconservedMenuItem.getState());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /*
@@ -5428,30 +5462,6 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
   }
 
   @Override
-  protected void showInformationHistogram_actionPerformed(ActionEvent e)
-  {
-    viewport.setShowInformationHistogram(
-            showInformationHistogram.getState());
-    alignPanel.updateAnnotation(applyAutoAnnotationSettings.getState());
-  }
-
-  @Override
-  protected void showHMMSequenceLogo_actionPerformed(ActionEvent e)
-  {
-    viewport.setShowHMMSequenceLogo(showHMMSequenceLogo.getState());
-    alignPanel.updateAnnotation(applyAutoAnnotationSettings.getState());
-  }
-
-  @Override
-  protected void normaliseHMMSequenceLogo_actionPerformed(ActionEvent e)
-  {
-    showHMMSequenceLogo.setState(true);
-    viewport.setShowHMMSequenceLogo(true);
-    viewport.setNormaliseHMMSequenceLogo(normaliseSequenceLogo.getState());
-    alignPanel.updateAnnotation(applyAutoAnnotationSettings.getState());
-  }
-
-  @Override
   protected void applyAutoAnnotationSettings_actionPerformed(ActionEvent e)
   {
     alignPanel.updateAnnotation(applyAutoAnnotationSettings.getState());
@@ -5471,7 +5481,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     {
       PaintRefresher.Refresh(this, viewport.getSequenceSetId());
       alignPanel.updateAnnotation();
-      alignPanel.paintAlignment(true);
+      alignPanel.paintAlignment(true, true);
     }
   }
 
@@ -5483,7 +5493,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
       viewport.getAlignment().setSeqrep(null);
       PaintRefresher.Refresh(this, viewport.getSequenceSetId());
       alignPanel.updateAnnotation();
-      alignPanel.paintAlignment(true);
+      alignPanel.paintAlignment(true, true);
     }
   }
 
@@ -5573,7 +5583,7 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     this.alignPanel.av.setSortAnnotationsBy(getAnnotationSortOrder());
     this.alignPanel.av
             .setShowAutocalculatedAbove(isShowAutoCalculatedAbove());
-    alignPanel.paintAlignment(true);
+    alignPanel.paintAlignment(false, false);
   }
 
   /**
@@ -5779,50 +5789,10 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
 
   /**
    * Sets the status of the HMMER menu
-   * 
-   * @param status
    */
-  public void updateHMMERStatus(boolean status)
+  public void updateHMMERStatus()
   {
-    hmmerMenu.setEnabled(status);
-  }
-
-  /**
-   * Returns the selected hidden Markov model.
-   * 
-   * @return
-   */
-  public HiddenMarkovModel getSelectedHMM()
-  {
-    if (selectedHMMSequence == null)
-    {
-      return null;
-    }
-    return selectedHMMSequence.getHMM();
-  }
-
-  /**
-   * Returns the selected hidden Markov model.
-   * 
-   * @return
-   */
-  public SequenceI getSelectedHMMSequence()
-  {
-    return selectedHMMSequence;
-  }
-
-  /**
-   * Sets the selected hidden Markov model
-   * 
-   * @param selectedHMM
-   */
-  public void setSelectedHMMSequence(SequenceI selectedHMM)
-  {
-    this.selectedHMMSequence = selectedHMM;
-    hmmAlign.setText(MessageManager.getString("label.hmmalign") + " to "
-            + selectedHMM.getHMM().getName() + "_HMM");
-    hmmSearch.setText(MessageManager.getString("label.hmmsearch") + " with "
-            + selectedHMM.getHMM().getName() + "_HMM");
+    hmmerMenu.setEnabled(HmmerCommand.isHmmerAvailable());
   }
 
   @Override
@@ -5841,6 +5811,26 @@ public class AlignFrame extends GAlignFrame implements DropTargetListener,
     }
   }
 
+  @Override
+  protected void loadVcf_actionPerformed()
+  {
+    JalviewFileChooser chooser = new JalviewFileChooser(
+            Cache.getProperty("LAST_DIRECTORY"));
+    chooser.setFileView(new JalviewFileView());
+    chooser.setDialogTitle(MessageManager.getString("label.load_vcf_file"));
+    chooser.setToolTipText(MessageManager.getString("label.load_vcf_file"));
+
+    int value = chooser.showOpenDialog(null);
+
+    if (value == JalviewFileChooser.APPROVE_OPTION)
+    {
+      String choice = chooser.getSelectedFile().getPath();
+      Cache.setProperty("LAST_DIRECTORY", choice);
+      SequenceI[] seqs = viewport.getAlignment().getSequencesArray();
+      new VCFLoader(choice).loadVCF(seqs, this);
+    }
+
+  }
 }
 
 class PrintThread extends Thread