import static org.testng.AssertJUnit.assertNull;
import static org.testng.AssertJUnit.assertSame;
import static org.testng.AssertJUnit.assertTrue;
+import static org.testng.AssertJUnit.fail;
import static org.testng.internal.junit.ArrayAsserts.assertArrayEquals;
-import jalview.gui.JvOptionPane;
-
import java.util.ArrayList;
import java.util.Arrays;
+import java.util.BitSet;
import java.util.List;
import org.testng.annotations.BeforeClass;
import org.testng.annotations.Test;
+import jalview.bin.Cache;
+import jalview.gui.JvOptionPane;
+
public class MapListTest
{
-
+ @BeforeClass(alwaysRun = true)
+ public void setUp()
+ {
+ Cache.initLogger();
+ }
+
@BeforeClass(alwaysRun = true)
public void setUpJvOptionPane()
{
JvOptionPane.setMockResponse(JvOptionPane.CANCEL_OPTION);
}
- @Test(groups = { "Functional" })
+ @Test(groups = { "Functional" }, enabled = false)
public void testSomething()
{
- MapList ml = new MapList(new int[] { 1, 5, 10, 15, 25, 20 }, new int[] {
- 51, 1 }, 1, 3);
+ MapList ml = new MapList(new int[] { 1, 5, 10, 15, 25, 20 },
+ new int[]
+ { 51, 1 }, 1, 3);
MapList ml1 = new MapList(new int[] { 1, 3, 17, 4 },
- new int[] { 51, 1 }, 1, 3);
+ new int[]
+ { 51, 1 }, 1, 3);
MapList ml2 = new MapList(new int[] { 1, 60 }, new int[] { 1, 20 }, 3,
1);
// test internal consistency
int to[] = new int[51];
testMap(ml, 1, 60);
- MapList mldna = new MapList(new int[] { 2, 2, 6, 8, 12, 16 }, new int[]
- { 1, 3 }, 3, 1);
+ MapList mldna = new MapList(new int[] { 2, 2, 6, 8, 12, 16 },
+ new int[]
+ { 1, 3 }, 3, 1);
int[] frm = mldna.locateInFrom(1, 1);
testLocateFrom(mldna, 1, 1, new int[] { 2, 2, 6, 7 });
testMap(mldna, 1, 3);
assertEquals("[10, 12]", Arrays.toString(ml.locateInFrom(4, 4)));
assertEquals("[1, 6]", Arrays.toString(ml.locateInFrom(1, 2)));
assertEquals("[1, 9]", Arrays.toString(ml.locateInFrom(1, 3)));
+ // reversed range treated as if forwards:
+ assertEquals("[1, 9]", Arrays.toString(ml.locateInFrom(3, 1)));
assertEquals("[1, 12]", Arrays.toString(ml.locateInFrom(1, 4)));
assertEquals("[4, 9]", Arrays.toString(ml.locateInFrom(2, 3)));
assertEquals("[4, 12]", Arrays.toString(ml.locateInFrom(2, 4)));
assertEquals("[7, 12]", Arrays.toString(ml.locateInFrom(3, 4)));
assertEquals("[10, 12]", Arrays.toString(ml.locateInFrom(4, 4)));
+ /*
+ * partial overlap
+ */
+ assertEquals("[1, 12]", Arrays.toString(ml.locateInFrom(1, 5)));
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInFrom(-1, 1)));
+
+ /*
+ * no overlap
+ */
assertNull(ml.locateInFrom(0, 0));
- assertNull(ml.locateInFrom(1, 5));
- assertNull(ml.locateInFrom(-1, 1));
+
}
/**
assertEquals("[10, 10, 12, 12, 14, 14]",
Arrays.toString(ml.locateInFrom(3, 3)));
assertEquals("[16, 18]", Arrays.toString(ml.locateInFrom(4, 4)));
+
+ /*
+ * codons at 11-16, 21-26, 31-36 mapped to peptide positions 1, 3-4, 6-8
+ */
+ ml = new MapList(new int[] { 11, 16, 21, 26, 31, 36 },
+ new int[]
+ { 1, 1, 3, 4, 6, 8 }, 3, 1);
+ assertArrayEquals(new int[] { 11, 13 }, ml.locateInFrom(1, 1));
+ assertArrayEquals(new int[] { 11, 16 }, ml.locateInFrom(1, 3));
+ assertArrayEquals(new int[] { 11, 16, 21, 23 }, ml.locateInFrom(1, 4));
+ assertArrayEquals(new int[] { 14, 16, 21, 23 }, ml.locateInFrom(3, 4));
+
+ }
+
+ @Test(groups = { "Functional" })
+ public void testLocateInFrom_reverseStrand()
+ {
+ int[] codons = new int[] { 12, 1 };
+ int[] protein = new int[] { 1, 4 };
+ MapList ml = new MapList(codons, protein, 3, 1);
+ assertEquals("[12, 10]", Arrays.toString(ml.locateInFrom(1, 1)));
+ assertEquals("[9, 4]", Arrays.toString(ml.locateInFrom(2, 3)));
}
/**
assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(1, 12)));
assertEquals("[2, 2]", Arrays.toString(ml.locateInTo(4, 6)));
assertEquals("[2, 4]", Arrays.toString(ml.locateInTo(4, 12)));
+ // reverse range treated as if forwards:
+ assertEquals("[2, 4]", Arrays.toString(ml.locateInTo(12, 4)));
/*
* A part codon is treated as if a whole one.
assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(3, 11)));
assertEquals("[2, 4]", Arrays.toString(ml.locateInTo(5, 11)));
+ /*
+ * partial overlap
+ */
+ assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(1, 13)));
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(-1, 2)));
+
+ /*
+ * no overlap
+ */
assertNull(ml.locateInTo(0, 0));
- assertNull(ml.locateInTo(1, 13));
- assertNull(ml.locateInTo(-1, 1));
}
/**
MapList ml = new MapList(codons, protein, 3, 1);
/*
- * Can't map from an unmapped position
- */
- assertNull(ml.locateInTo(1, 2));
- assertNull(ml.locateInTo(2, 4));
- assertNull(ml.locateInTo(4, 4));
-
- /*
- * Valid range or subrange of codon1 maps to protein1.
+ * Valid range or subrange of codon1 maps to protein1
*/
assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(2, 2)));
assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(3, 3)));
// codon positions 7 to 17 (part) cover proteins 2/3/4 at positions 3/4/6
assertEquals("[3, 4, 6, 6]", Arrays.toString(ml.locateInTo(7, 17)));
+ /*
+ * partial overlap
+ */
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(1, 2)));
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(1, 4)));
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(2, 4)));
+
+ /*
+ * no overlap
+ */
+ assertNull(ml.locateInTo(4, 4));
}
/**
List<int[]> ranges = new ArrayList<>();
ranges.add(new int[] { 2, 3 });
ranges.add(new int[] { 5, 6 });
- assertEquals("[2, 3, 5, 6]", Arrays.toString(MapList.getRanges(ranges)));
+ assertEquals("[2, 3, 5, 6]",
+ Arrays.toString(MapList.getRanges(ranges)));
}
/**
assertEquals(6, ml2.getToHighest());
assertEquals("{[2, 3], [5, 7], [9, 10], [12, 12], [14, 14], [16, 18]}",
prettyPrint(ml2.getFromRanges()));
- assertEquals("{[1, 1], [3, 4], [6, 6]}", prettyPrint(ml2.getToRanges()));
+ assertEquals("{[1, 1], [3, 4], [6, 6]}",
+ prettyPrint(ml2.getToRanges()));
/*
* reverse direction
}
/**
- * Test constructor can merge consecutive ranges
+ * Test constructor used to merge consecutive ranges but now just leaves them
+ * as supplied (JAL-3751)
*/
@Test(groups = { "Functional" })
public void testConstructor_mergeRanges()
{
- int[] codons = { 2, 3, 3, 7, 9, 10, 12, 12, 14, 14, 16, 17 };
- int[] protein = { 1, 1, 1, 3, 6, 6 };
+ int[] codons = { 2, 3, 3, 7, 9, 10, 12, 12, 13, 14, 16, 17 };
+ int[] protein = { 1, 1, 2, 3, 6, 6 };
MapList ml = new MapList(codons, protein, 3, 1);
assertEquals(3, ml.getFromRatio());
assertEquals(2, ml.getFromLowest());
assertEquals(17, ml.getFromHighest());
assertEquals(1, ml.getToLowest());
assertEquals(6, ml.getToHighest());
- assertEquals("{[2, 7], [9, 10], [12, 12], [14, 14], [16, 17]}",
+ assertEquals("{[2, 3], [3, 7], [9, 10], [12, 12], [13, 14], [16, 17]}",
prettyPrint(ml.getFromRanges()));
- assertEquals("{[1, 3], [6, 6]}", prettyPrint(ml.getToRanges()));
+ assertEquals("{[1, 1], [2, 3], [6, 6]}", prettyPrint(ml.getToRanges()));
}
/**
@Test(groups = { "Functional" })
public void testToString()
{
- MapList ml = new MapList(new int[] { 1, 5, 10, 15, 25, 20 }, new int[] {
- 51, 1 }, 1, 3);
+ MapList ml = new MapList(new int[] { 1, 5, 10, 15, 25, 20 },
+ new int[]
+ { 51, 1 }, 1, 3);
String s = ml.toString();
assertEquals("[ [1, 5] [10, 15] [25, 20] ] 1:3 to [ [51, 1] ]", s);
}
public void testAddMapList()
{
MapList ml = new MapList(new int[] { 11, 15, 20, 25, 35, 30 },
- new int[] { 72, 22 }, 1, 3);
+ new int[]
+ { 72, 22 }, 1, 3);
assertEquals(11, ml.getFromLowest());
assertEquals(35, ml.getFromHighest());
assertEquals(22, ml.getToLowest());
assertEquals(72, ml.getToHighest());
- MapList ml2 = new MapList(new int[] { 2, 4, 37, 40 }, new int[] { 12,
- 17, 78, 83, 88, 96 }, 1, 3);
+ MapList ml2 = new MapList(new int[] { 2, 4, 37, 40 },
+ new int[]
+ { 12, 17, 78, 83, 88, 96 }, 1, 3);
ml.addMapList(ml2);
assertEquals(2, ml.getFromLowest());
assertEquals(40, ml.getFromHighest());
public void testAddMapList_sameMap()
{
MapList ml = new MapList(new int[] { 11, 15, 20, 25, 35, 30 },
- new int[] { 72, 22 }, 1, 3);
+ new int[]
+ { 72, 22 }, 1, 3);
String before = ml.toString();
ml.addMapList(ml);
assertEquals(before, ml.toString());
MapList ml = new MapList(new int[] { 11, 15 }, new int[] { 72, 58 }, 1,
3);
- MapList ml2 = new MapList(new int[] { 15, 16 }, new int[] { 58, 53 },
- 1, 3);
+ MapList ml2 = new MapList(new int[] { 15, 16 }, new int[] { 58, 53 }, 1,
+ 3);
ml.addMapList(ml2);
assertEquals("[ [11, 16] ] 1:3 to [ [72, 53] ]", ml.toString());
}
public void testIsFromForwardStrand()
{
// [3-9] declares forward strand
- MapList ml = new MapList(new int[] { 2, 2, 3, 9, 12, 11 }, new int[] {
- 20, 11 }, 1, 1);
+ MapList ml = new MapList(new int[] { 2, 2, 3, 9, 12, 11 },
+ new int[]
+ { 20, 11 }, 1, 1);
assertTrue(ml.isFromForwardStrand());
// [11-5] declares reverse strand ([13-14] is ignored)
ml = new MapList(new int[] { 2, 2, 11, 5, 13, 14 },
- new int[] { 20, 11 }, 1, 1);
+ new int[]
+ { 20, 11 }, 1, 1);
assertFalse(ml.isFromForwardStrand());
// all single position ranges - defaults to forward strand
}
/**
- * Test the method that merges a list of ranges where possible
+ * Test the method that merges contiguous ranges
*/
@Test(groups = { "Functional" })
public void testCoalesceRanges()
// merging in forward direction:
ranges.clear();
ranges.add(new int[] { 1, 3 });
- ranges.add(new int[] { 4, 5 });
- ranges.add(new int[] { 5, 5 });
- ranges.add(new int[] { 5, 7 });
+ ranges.add(new int[] { 4, 5 }); // contiguous
+ ranges.add(new int[] { 5, 5 }); // overlap!
+ ranges.add(new int[] { 6, 7 }); // contiguous
List<int[]> merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 1, 7 }, merged.get(0));
+ assertEquals(2, merged.size());
+ assertArrayEquals(new int[] { 1, 5 }, merged.get(0));
+ assertArrayEquals(new int[] { 5, 7 }, merged.get(1));
// verify input list is unchanged
assertEquals(4, ranges.size());
assertArrayEquals(new int[] { 1, 3 }, ranges.get(0));
assertArrayEquals(new int[] { 4, 5 }, ranges.get(1));
assertArrayEquals(new int[] { 5, 5 }, ranges.get(2));
- assertArrayEquals(new int[] { 5, 7 }, ranges.get(3));
+ assertArrayEquals(new int[] { 6, 7 }, ranges.get(3));
// merging in reverse direction:
ranges.clear();
ranges.add(new int[] { 7, 5 });
- ranges.add(new int[] { 5, 4 });
- ranges.add(new int[] { 4, 4 });
- ranges.add(new int[] { 3, 1 });
+ ranges.add(new int[] { 5, 4 }); // overlap
+ ranges.add(new int[] { 4, 4 }); // overlap
+ ranges.add(new int[] { 3, 1 }); // contiguous
merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 7, 1 }, merged.get(0));
+ assertEquals(3, merged.size());
+ assertArrayEquals(new int[] { 7, 5 }, merged.get(0));
+ assertArrayEquals(new int[] { 5, 4 }, merged.get(1));
+ assertArrayEquals(new int[] { 4, 1 }, merged.get(2));
// merging with switches of direction:
ranges.clear();
ranges.add(new int[] { 1, 3 });
- ranges.add(new int[] { 4, 5 });
- ranges.add(new int[] { 5, 5 });
- ranges.add(new int[] { 6, 6 });
+ ranges.add(new int[] { 4, 5 }); // contiguous
+ ranges.add(new int[] { 5, 5 }); // overlap
+ ranges.add(new int[] { 6, 6 }); // contiguous
ranges.add(new int[] { 12, 10 });
- ranges.add(new int[] { 9, 8 });
- ranges.add(new int[] { 8, 8 });
- ranges.add(new int[] { 7, 7 });
+ ranges.add(new int[] { 9, 8 }); // contiguous
+ ranges.add(new int[] { 8, 8 }); // overlap
+ ranges.add(new int[] { 7, 7 }); // contiguous
merged = MapList.coalesceRanges(ranges);
- assertEquals(2, merged.size());
- assertArrayEquals(new int[] { 1, 6 }, merged.get(0));
- assertArrayEquals(new int[] { 12, 7 }, merged.get(1));
- }
-
- /**
- * Test the method that merges a list of ranges where possible
- */
- @Test(groups = { "Functional" })
- public void testCoalesceRanges_withOverlap()
- {
- List<int[]> ranges = new ArrayList<>();
- ranges.add(new int[] { 1, 3 });
- ranges.add(new int[] { 2, 5 });
-
- /*
- * [2, 5] should extend [1, 3]
- */
- List<int[]> merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
+ assertEquals(4, merged.size());
assertArrayEquals(new int[] { 1, 5 }, merged.get(0));
-
- /*
- * a subsumed interval should be dropped
- */
- ranges.clear();
- ranges.add(new int[] { 1, 6 });
- ranges.add(new int[] { 2, 4 });
- merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 1, 6 }, merged.get(0));
-
+ assertArrayEquals(new int[] { 5, 6 }, merged.get(1));
+ assertArrayEquals(new int[] { 12, 8 }, merged.get(2));
+ assertArrayEquals(new int[] { 8, 7 }, merged.get(3));
+
+ // 'subsumed' ranges are preserved
ranges.clear();
- ranges.add(new int[] { 1, 5 });
- ranges.add(new int[] { 1, 6 });
- merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 1, 6 }, merged.get(0));
-
- /*
- * merge duplicate ranges
- */
- ranges.clear();
- ranges.add(new int[] { 1, 3 });
- ranges.add(new int[] { 1, 3 });
- merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 1, 3 }, merged.get(0));
+ ranges.add(new int[] { 10, 30 });
+ ranges.add(new int[] { 15, 25 });
- /*
- * reverse direction
- */
- ranges.clear();
- ranges.add(new int[] { 9, 5 });
- ranges.add(new int[] { 9, 4 });
- ranges.add(new int[] { 8, 3 });
- ranges.add(new int[] { 3, 2 });
- ranges.add(new int[] { 1, 0 });
merged = MapList.coalesceRanges(ranges);
- assertEquals(1, merged.size());
- assertArrayEquals(new int[] { 9, 0 }, merged.get(0));
+ assertEquals(2, merged.size());
+ assertArrayEquals(new int[] { 10, 30 }, merged.get(0));
+ assertArrayEquals(new int[] { 15, 25 }, merged.get(1));
}
/**
/*
* simple 1:1 plus 1:1 forwards
*/
- MapList ml1 = new MapList(new int[] { 3, 4, 8, 12 }, new int[] { 5, 8,
- 11, 13 }, 1, 1);
+ MapList ml1 = new MapList(new int[] { 3, 4, 8, 12 },
+ new int[]
+ { 5, 8, 11, 13 }, 1, 1);
assertEquals("{[3, 4], [8, 12]}", prettyPrint(ml1.getFromRanges()));
assertEquals("{[5, 8], [11, 13]}", prettyPrint(ml1.getToRanges()));
- MapList ml2 = new MapList(new int[] { 1, 50 }, new int[] { 40, 45, 70,
- 75, 90, 127 }, 1, 1);
+ MapList ml2 = new MapList(new int[] { 1, 50 },
+ new int[]
+ { 40, 45, 70, 75, 90, 127 }, 1, 1);
assertEquals("{[1, 50]}", prettyPrint(ml2.getFromRanges()));
assertEquals("{[40, 45], [70, 75], [90, 127]}",
prettyPrint(ml2.getToRanges()));
*/
ml1 = new MapList(new int[] { 1, 50 }, new int[] { 70, 119 }, 1, 1);
ml2 = new MapList(new int[] { 1, 500 },
- new int[] { 1000, 901, 600, 201 }, 1, 1);
+ new int[]
+ { 1000, 901, 600, 201 }, 1, 1);
compound = ml1.traverse(ml2);
assertEquals(1, compound.getFromRatio());
toRanges = compound.getToRanges();
assertEquals(2, toRanges.size());
assertArrayEquals(new int[] { 931, 901 }, toRanges.get(0));
- assertArrayEquals(new int[] { 600, 582 }, toRanges.get(1));
+ assertArrayEquals(new int[] { 600, 582}, toRanges.get(1));
/*
* 1:1 plus 1:3 should result in 1:3
*/
ml1 = new MapList(new int[] { 1, 30 }, new int[] { 11, 40 }, 1, 1);
- ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 50, 91, 340 },
- 1, 3);
+ ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 50, 91, 340 }, 1,
+ 3);
compound = ml1.traverse(ml2);
assertEquals(1, compound.getFromRatio());
* 3:1 plus 1:1 should result in 3:1
*/
ml1 = new MapList(new int[] { 1, 30 }, new int[] { 11, 20 }, 3, 1);
- ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 15, 91, 175 },
- 1, 1);
+ ml2 = new MapList(new int[] { 1, 100 }, new int[] { 1, 15, 91, 175 }, 1,
+ 1);
compound = ml1.traverse(ml2);
assertEquals(3, compound.getFromRatio());
assertArrayEquals(new int[] { 71, 126 }, toRanges.get(1));
/*
- * method returns null if not all regions are mapped through
+ * if not all regions are mapped through, returns what is
*/
ml1 = new MapList(new int[] { 1, 50 }, new int[] { 101, 150 }, 1, 1);
- ml2 = new MapList(new int[] { 131, 180 }, new int[] { 201, 250 }, 1, 3);
+ ml2 = new MapList(new int[] { 131, 180 }, new int[] { 201, 250 }, 1, 1);
compound = ml1.traverse(ml2);
assertNull(compound);
}
/**
- * Test that method that inspects for the (first) forward or reverse 'to' range.
- * Single position ranges are ignored.
+ * Test that method that inspects for the (first) forward or reverse 'to'
+ * range. Single position ranges are ignored.
*/
@Test(groups = { "Functional" })
public void testIsToForwardsStrand()
1);
assertTrue(ml.isToForwardStrand());
}
+
+ /**
+ * Test for mapping with overlapping ranges
+ */
+ @Test(groups = { "Functional" })
+ public void testLocateInFrom_withOverlap()
+ {
+ /*
+ * gene to protein...
+ */
+ int[] codons = new int[] { 1, 12, 12, 17 };
+ int[] protein = new int[] { 1, 6 };
+ MapList ml = new MapList(codons, protein, 3, 1);
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInFrom(1, 1)));
+ assertEquals("[4, 6]", Arrays.toString(ml.locateInFrom(2, 2)));
+ assertEquals("[7, 9]", Arrays.toString(ml.locateInFrom(3, 3)));
+ assertEquals("[10, 12]", Arrays.toString(ml.locateInFrom(4, 4)));
+ assertEquals("[12, 14]", Arrays.toString(ml.locateInFrom(5, 5)));
+ assertEquals("[15, 17]", Arrays.toString(ml.locateInFrom(6, 6)));
+ assertEquals("[1, 6]", Arrays.toString(ml.locateInFrom(1, 2)));
+ assertEquals("[1, 9]", Arrays.toString(ml.locateInFrom(1, 3)));
+ assertEquals("[1, 12]", Arrays.toString(ml.locateInFrom(1, 4)));
+ assertEquals("[1, 12, 12, 14]", Arrays.toString(ml.locateInFrom(1, 5)));
+ assertEquals("[1, 12, 12, 17]", Arrays.toString(ml.locateInFrom(1, 6)));
+ assertEquals("[4, 9]", Arrays.toString(ml.locateInFrom(2, 3)));
+ assertEquals("[7, 12, 12, 17]", Arrays.toString(ml.locateInFrom(3, 6)));
+
+ /*
+ * partial overlap of range
+ */
+ assertEquals("[4, 12, 12, 17]", Arrays.toString(ml.locateInFrom(2, 7)));
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInFrom(-1, 1)));
+
+ /*
+ * no overlap in range
+ */
+ assertNull(ml.locateInFrom(0, 0));
+
+ /*
+ * gene to CDS...from EMBL:MN908947
+ */
+ int[] gene = new int[] { 266, 13468, 13468, 21555 };
+ int[] cds = new int[] { 1, 21291 };
+ ml = new MapList(gene, cds, 1, 1);
+ assertEquals("[13468, 13468]",
+ Arrays.toString(ml.locateInFrom(13203, 13203)));
+ assertEquals("[13468, 13468]",
+ Arrays.toString(ml.locateInFrom(13204, 13204)));
+ assertEquals("[13468, 13468, 13468, 13468]",
+ Arrays.toString(ml.locateInFrom(13203, 13204)));
+ }
+
+ /**
+ * Test for mapping with overlapping ranges
+ */
+ @Test(groups = { "Functional" })
+ public void testLocateInTo_withOverlap()
+ {
+ /*
+ * gene to protein...
+ */
+ int[] codons = new int[] { 1, 12, 12, 17 };
+ int[] protein = new int[] { 1, 6 };
+ MapList ml = new MapList(codons, protein, 3, 1);
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(1, 1)));
+ assertEquals("[1, 3]", Arrays.toString(ml.locateInTo(3, 8)));
+ assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(2, 11)));
+ assertEquals("[1, 4]", Arrays.toString(ml.locateInTo(3, 11)));
+
+ // we want base 12 to map to both of the amino acids it codes for
+ assertEquals("[4, 5]", Arrays.toString(ml.locateInTo(12, 12)));
+ assertEquals("[4, 5]", Arrays.toString(ml.locateInTo(11, 12)));
+ assertEquals("[4, 6]", Arrays.toString(ml.locateInTo(11, 15)));
+ assertEquals("[6, 6]", Arrays.toString(ml.locateInTo(15, 17)));
+
+ /*
+ * no overlap
+ */
+ assertNull(ml.locateInTo(0, 0));
+
+ /*
+ * partial overlap
+ */
+ assertEquals("[1, 6]", Arrays.toString(ml.locateInTo(1, 18)));
+ assertEquals("[1, 1]", Arrays.toString(ml.locateInTo(-1, 1)));
+
+ /*
+ * gene to CDS...from EMBL:MN908947
+ * the base at 13468 is used twice in transcription
+ */
+ int[] gene = new int[] { 266, 13468, 13468, 21555 };
+ int[] cds = new int[] { 1, 21291 };
+ ml = new MapList(gene, cds, 1, 1);
+ assertEquals("[13203, 13204]",
+ Arrays.toString(ml.locateInTo(13468, 13468)));
+
+ /*
+ * gene to protein
+ * the base at 13468 is in the codon for 4401N and also 4402R
+ */
+ gene = new int[] { 266, 13468, 13468, 21552 }; // stop codon excluded
+ protein = new int[] { 1, 7096 };
+ ml = new MapList(gene, protein, 3, 1);
+ assertEquals("[4401, 4402]",
+ Arrays.toString(ml.locateInTo(13468, 13468)));
+ }
+
+ @Test(groups = { "Functional" })
+ public void testTraverseToPosition()
+ {
+ List<int[]> ranges = new ArrayList<>();
+ assertNull(MapList.traverseToPosition(ranges, 0));
+
+ ranges.add(new int[] { 3, 6 });
+ assertNull(MapList.traverseToPosition(ranges, 0));
+ }
+
+ @Test(groups = { "Functional" })
+ public void testCountPositions()
+ {
+ try
+ {
+ MapList.countPositions(null, 1);
+ fail("expected exception");
+ } catch (NullPointerException e)
+ {
+ // expected
+ }
+
+ List<int[]> intervals = new ArrayList<>();
+ assertNull(MapList.countPositions(intervals, 1));
+
+ /*
+ * forward strand
+ */
+ intervals.add(new int[] { 10, 20 });
+ assertNull(MapList.countPositions(intervals, 9));
+ assertNull(MapList.countPositions(intervals, 21));
+ assertArrayEquals(new int[] { 1, 1 },
+ MapList.countPositions(intervals, 10));
+ assertArrayEquals(new int[] { 6, 1 },
+ MapList.countPositions(intervals, 15));
+ assertArrayEquals(new int[] { 11, 1 },
+ MapList.countPositions(intervals, 20));
+
+ intervals.add(new int[] { 25, 25 });
+ assertArrayEquals(new int[] { 12, 1 },
+ MapList.countPositions(intervals, 25));
+
+ // next interval repeats position 25 - which should be counted twice if
+ // traversed
+ intervals.add(new int[] { 25, 26 });
+ assertArrayEquals(new int[] { 12, 1 },
+ MapList.countPositions(intervals, 25));
+ assertArrayEquals(new int[] { 14, 1 },
+ MapList.countPositions(intervals, 26));
+
+ /*
+ * reverse strand
+ */
+ intervals.clear();
+ intervals.add(new int[] { 5, -5 });
+ assertNull(MapList.countPositions(intervals, 6));
+ assertNull(MapList.countPositions(intervals, -6));
+ assertArrayEquals(new int[] { 1, -1 },
+ MapList.countPositions(intervals, 5));
+ assertArrayEquals(new int[] { 7, -1 },
+ MapList.countPositions(intervals, -1));
+ assertArrayEquals(new int[] { 11, -1 },
+ MapList.countPositions(intervals, -5));
+
+ /*
+ * reverse then forward
+ */
+ intervals.add(new int[] { 5, 10 });
+ assertArrayEquals(new int[] { 13, 1 },
+ MapList.countPositions(intervals, 6));
+
+ /*
+ * reverse then forward then reverse
+ */
+ intervals.add(new int[] { -10, -20 });
+ assertArrayEquals(new int[] { 20, -1 },
+ MapList.countPositions(intervals, -12));
+
+ /*
+ * an interval [x, x] is treated as forward
+ */
+ intervals.add(new int[] { 30, 30 });
+ assertArrayEquals(new int[] { 29, 1 },
+ MapList.countPositions(intervals, 30));
+
+ /*
+ * it is the first matched occurrence that is returned
+ */
+ intervals.clear();
+ intervals.add(new int[] { 1, 2 });
+ intervals.add(new int[] { 2, 3 });
+ assertArrayEquals(new int[] { 2, 1 },
+ MapList.countPositions(intervals, 2));
+ intervals.add(new int[] { -1, -2 });
+ intervals.add(new int[] { -2, -3 });
+ assertArrayEquals(new int[] { 6, -1 },
+ MapList.countPositions(intervals, -2));
+ }
+
+ /**
+ * Tests for helper method that adds any overlap (plus offset) to a set of
+ * overlaps
+ */
+ @Test(groups = { "Functional" })
+ public void testAddOffsetPositions()
+ {
+ List<int[]> mapped = new ArrayList<>();
+ int[] range = new int[] {10, 20};
+ BitSet offsets = new BitSet();
+
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertTrue(mapped.isEmpty()); // nothing marked for overlap
+
+ offsets.set(11);
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertTrue(mapped.isEmpty()); // no offset 11 in range
+
+ offsets.set(4, 6); // this sets bits 4 and 5
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertEquals(1, mapped.size());
+ assertArrayEquals(new int[] { 14, 15 }, mapped.get(0));
+
+ mapped.clear();
+ offsets.set(10);
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertEquals(2, mapped.size());
+ assertArrayEquals(new int[] { 14, 15 }, mapped.get(0));
+ assertArrayEquals(new int[] { 20, 20 }, mapped.get(1));
+
+ /*
+ * reverse range
+ */
+ range = new int[] { 20, 10 };
+ mapped.clear();
+ offsets.clear();
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertTrue(mapped.isEmpty()); // nothing marked for overlap
+ offsets.set(11);
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertTrue(mapped.isEmpty()); // no offset 11 in range
+ offsets.set(0);
+ offsets.set(10);
+ offsets.set(6, 8); // sets bits 6 and 7
+ MapList.addOffsetPositions(mapped, 0, range, offsets);
+ assertEquals(3, mapped.size());
+ assertArrayEquals(new int[] { 20, 20 }, mapped.get(0));
+ assertArrayEquals(new int[] { 14, 13 }, mapped.get(1));
+ assertArrayEquals(new int[] { 10, 10 }, mapped.get(2));
+ }
+
+ @Test(groups = { "Functional" })
+ public void testGetPositionsForOffsets()
+ {
+ List<int[]> ranges = new ArrayList<>();
+ BitSet offsets = new BitSet();
+ List<int[]> mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertTrue(mapped.isEmpty()); // no ranges and no offsets!
+
+ offsets.set(5, 1000);
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertTrue(mapped.isEmpty()); // no ranges
+
+ /*
+ * one range with overlap of offsets
+ */
+ ranges.add(new int[] {15, 25});
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(1, mapped.size());
+ assertArrayEquals(new int[] {20, 25}, mapped.get(0));
+
+ /*
+ * two ranges
+ */
+ ranges.add(new int[] {300, 320});
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(2, mapped.size());
+ assertArrayEquals(new int[] {20, 25}, mapped.get(0));
+ assertArrayEquals(new int[] {300, 320}, mapped.get(1));
+
+ /*
+ * boundary case - right end of first range overlaps
+ */
+ offsets.clear();
+ offsets.set(10);
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(1, mapped.size());
+ assertArrayEquals(new int[] {25, 25}, mapped.get(0));
+
+ /*
+ * boundary case - left end of second range overlaps
+ */
+ offsets.set(11);
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(2, mapped.size());
+ assertArrayEquals(new int[] {25, 25}, mapped.get(0));
+ assertArrayEquals(new int[] {300, 300}, mapped.get(1));
+
+ /*
+ * offsets into a circular range are reported in
+ * the order in which they are traversed
+ */
+ ranges.clear();
+ ranges.add(new int[] {100, 150});
+ ranges.add(new int[] {60, 80});
+ offsets.clear();
+ offsets.set(45, 55); // sets bits 45 to 54
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(2, mapped.size());
+ assertArrayEquals(new int[] {145, 150}, mapped.get(0)); // offsets 45-50
+ assertArrayEquals(new int[] {60, 63}, mapped.get(1)); // offsets 51-54
+
+ /*
+ * reverse range overlap is reported with start < end
+ */
+ ranges.clear();
+ ranges.add(new int[] {4321, 4000});
+ offsets.clear();
+ offsets.set(20, 22); // sets bits 20 and 21
+ offsets.set(30);
+ mapped = MapList.getPositionsForOffsets(ranges, offsets);
+ assertEquals(2, mapped.size());
+ assertArrayEquals(new int[] {4301, 4300}, mapped.get(0));
+ assertArrayEquals(new int[] {4291, 4291}, mapped.get(1));
+ }
+
+ @Test(groups = { "Functional" })
+ public void testGetMappedOffsetsForPositions()
+ {
+ /*
+ * start by verifying the examples in the method's Javadoc!
+ */
+ List<int[]> ranges = new ArrayList<>();
+ ranges.add(new int[] {10, 20});
+ ranges.add(new int[] {31, 40});
+ BitSet overlaps = MapList.getMappedOffsetsForPositions(1, 9, ranges, 1, 1);
+ assertTrue(overlaps.isEmpty());
+ overlaps = MapList.getMappedOffsetsForPositions(1, 11, ranges, 1, 1);
+ assertEquals(2, overlaps.cardinality());
+ assertTrue(overlaps.get(0));
+ assertTrue(overlaps.get(1));
+ overlaps = MapList.getMappedOffsetsForPositions(15, 35, ranges, 1, 1);
+ assertEquals(11, overlaps.cardinality());
+ for (int i = 5 ; i <= 11 ; i++)
+ {
+ assertTrue(overlaps.get(i));
+ }
+
+ ranges.clear();
+ ranges.add(new int[] {1, 200});
+ overlaps = MapList.getMappedOffsetsForPositions(9, 9, ranges, 1, 3);
+ assertEquals(3, overlaps.cardinality());
+ assertTrue(overlaps.get(24));
+ assertTrue(overlaps.get(25));
+ assertTrue(overlaps.get(26));
+
+ ranges.clear();
+ ranges.add(new int[] {101, 150});
+ ranges.add(new int[] {171, 180});
+ overlaps = MapList.getMappedOffsetsForPositions(101, 102, ranges, 3, 1);
+ assertEquals(1, overlaps.cardinality());
+ assertTrue(overlaps.get(0));
+ overlaps = MapList.getMappedOffsetsForPositions(150, 171, ranges, 3, 1);
+ assertEquals(1, overlaps.cardinality());
+ assertTrue(overlaps.get(16));
+
+ ranges.clear();
+ ranges.add(new int[] {101, 150});
+ ranges.add(new int[] {21, 30});
+ overlaps = MapList.getMappedOffsetsForPositions(24, 40, ranges, 3, 1);
+ assertEquals(3, overlaps.cardinality());
+ assertTrue(overlaps.get(17));
+ assertTrue(overlaps.get(18));
+ assertTrue(overlaps.get(19));
+
+ /*
+ * reverse range 1:1 (e.g. reverse strand gene to transcript)
+ */
+ ranges.clear();
+ ranges.add(new int[] {20, 10});
+ overlaps = MapList.getMappedOffsetsForPositions(12, 13, ranges, 1, 1);
+ assertEquals(2, overlaps.cardinality());
+ assertTrue(overlaps.get(7));
+ assertTrue(overlaps.get(8));
+
+ /*
+ * reverse range 3:1 (e.g. reverse strand gene to peptide)
+ * from EMBL:J03321 to P0CE20
+ */
+ ranges.clear();
+ ranges.add(new int[] {1480, 488});
+ overlaps = MapList.getMappedOffsetsForPositions(1460, 1460, ranges, 3, 1);
+ // 1460 is the end of the 7th codon
+ assertEquals(1, overlaps.cardinality());
+ assertTrue(overlaps.get(6));
+ // add one base (part codon)
+ overlaps = MapList.getMappedOffsetsForPositions(1459, 1460, ranges, 3, 1);
+ assertEquals(2, overlaps.cardinality());
+ assertTrue(overlaps.get(6));
+ assertTrue(overlaps.get(7));
+ // add second base (part codon)
+ overlaps = MapList.getMappedOffsetsForPositions(1458, 1460, ranges, 3, 1);
+ assertEquals(2, overlaps.cardinality());
+ assertTrue(overlaps.get(6));
+ assertTrue(overlaps.get(7));
+ // add third base (whole codon)
+ overlaps = MapList.getMappedOffsetsForPositions(1457, 1460, ranges, 3, 1);
+ assertEquals(2, overlaps.cardinality());
+ assertTrue(overlaps.get(6));
+ assertTrue(overlaps.get(7));
+ // add one more base (part codon)
+ overlaps = MapList.getMappedOffsetsForPositions(1456, 1460, ranges, 3, 1);
+ assertEquals(3, overlaps.cardinality());
+ assertTrue(overlaps.get(6));
+ assertTrue(overlaps.get(7));
+ assertTrue(overlaps.get(8));
+ }
}
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