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63 <div class="contents">
64 <h1>Calculate Secondary Structures of two RNAs upon Dimerization<br/>
66 [<a class="el" href="group__folding__routines.html">RNA Secondary Structure Folding</a>]</small>
68 <p>Predict structures formed by two molecules upon hybridization.
69 <a href="#_details">More...</a></p>
71 <p><div class="dynheader">
72 Collaboration diagram for Calculate Secondary Structures of two RNAs upon Dimerization:</div>
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74 <center><table><tr><td><img src="group__cofold.png" border="0" alt="" usemap="#group____cofold_map"/>
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76 <area shape="rect" id="node1" href="group__up__cofold.html" title="Partition Function Cofolding as a stepwise process." alt="" coords="729,5,1175,35"/><area shape="rect" id="node2" href="group__mfe__cofold.html" title="MFE Structures of two hybridized Sequences" alt="" coords="807,58,1097,89"/><area shape="rect" id="node3" href="group__folding__routines.html" title="This module contains all functions related to thermodynamic folding of RNAs." alt="" coords="5,58,229,89"/><area shape="rect" id="node5" href="group__pf__cofold.html" title="Partition Function Cofolding." alt="" coords="800,111,1104,142"/></map></td></tr></table></center>
79 <table border="0" cellpadding="0" cellspacing="0">
80 <tr><td colspan="2"><h2>Modules</h2></td></tr>
81 <tr><td class="memItemLeft" align="right" valign="top"> </td><td class="memItemRight" valign="bottom"><a class="el" href="group__mfe__cofold.html">MFE Structures of two hybridized Sequences</a></td></tr>
82 <tr><td class="memItemLeft" align="right" valign="top"> </td><td class="memItemRight" valign="bottom"><a class="el" href="group__pf__cofold.html">Partition Function for two hybridized Sequences</a></td></tr>
84 <p><tr><td class="mdescLeft"> </td><td class="mdescRight"><p>Partition Function Cofolding. </p>
87 <tr><td class="memItemLeft" align="right" valign="top"> </td><td class="memItemRight" valign="bottom"><a class="el" href="group__up__cofold.html">Partition Function for two hybridized Sequences as a stepwise Process</a></td></tr>
89 <p><tr><td class="mdescLeft"> </td><td class="mdescRight"><p>Partition Function Cofolding as a stepwise process. </p>
93 <hr/><a name="_details"></a><h2>Detailed Description</h2>
94 <p>Predict structures formed by two molecules upon hybridization. </p>
95 <p>The function of an RNA molecule often depends on its interaction with other RNAs. The following routines therefore allow to predict structures formed by two RNA molecules upon hybridization.<br/>
96 One approach to co-folding two RNAs consists of concatenating the two sequences and keeping track of the concatenation point in all energy evaluations. Correspondingly, many of the <a class="el" href="group__mfe__cofold.html#gabc8517f22cfe70595ee81fc837910d52" title="Compute the minimum free energy of two interacting RNA molecules.">cofold()</a> and <a class="el" href="group__pf__cofold.html#gaa86a5f998789ed71813d23d7307a791b" title="Calculate partition function and base pair probabilities.">co_pf_fold()</a> routines below take one sequence string as argument and use the the global variable <a class="el" href="fold__vars_8h.html#ab9b2c3a37a5516614c06d0ab54b97cda" title="Marks the position (starting from 1) of the first nucleotide of the second molecule...">cut_point</a> to mark the concatenation point. Note that while the <em>RNAcofold</em> program uses the '&' character to mark the chain break in its input, you should not use an '&' when using the library routines (set <a class="el" href="fold__vars_8h.html#ab9b2c3a37a5516614c06d0ab54b97cda" title="Marks the position (starting from 1) of the first nucleotide of the second molecule...">cut_point</a> instead).<br/>
97 In a second approach to co-folding two RNAs, cofolding is seen as a stepwise process. In the first step the probability of an unpaired region is calculated and in a second step this probability of an unpaired region is multiplied with the probability of an interaction between the two RNAs. This approach is implemented for the interaction between a long target sequence and a short ligand RNA. Function <a class="el" href="group__up__cofold.html#ga5b4ee40e190d2f633cd01cf0d2fe93cf" title="Calculate the partition function over all unpaired regions of a maximal length.">pf_unstru()</a> calculates the partition function over all unpaired regions in the input sequence. Function <a class="el" href="group__up__cofold.html#ga1aa0aa02bc3a724f87360c03097afd00" title="Calculates the probability of a local interaction between two sequences.">pf_interact()</a>, which calculates the partition function over all possible interactions between two sequences, needs both sequence as separate strings as input. </p>
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