+++ /dev/null
-#include "mltaln.h"
-
-#define DEBUG 0
-#define IODEBUG 0
-#define SCOREOUT 0
-
-#define END_OF_VEC -1
-
-static int treein;
-static int topin;
-static int treeout;
-static int noalign;
-static int distout;
-static float lenfaca, lenfacb, lenfacc, lenfacd;
-#if 0
-#define PLENFACA 0.0123
-#define PLENFACB 10252
-#define PLENFACC 10822
-#define PLENFACD 0.5
-#define DLENFACA 0.01
-#define DLENFACB 2445
-#define DLENFACC 2412
-#define DLENFACD 0.1
-#else
-#define PLENFACA 0.01
-#define PLENFACB 10000
-#define PLENFACC 10000
-#define PLENFACD 0.1
-#define DLENFACA 0.01
-#define DLENFACB 2500
-#define DLENFACC 2500
-#define DLENFACD 0.1
-#endif
-
-
-void arguments( int argc, char *argv[] )
-{
- int c;
-
- topin = 0;
- treein = 0;
- treeout = 0;
- distout = 0;
- noalign = 0;
- nevermemsave = 0;
- inputfile = NULL;
- fftkeika = 0;
- constraint = 0;
- nblosum = 62;
- fmodel = 0;
- calledByXced = 0;
- devide = 0;
- use_fft = 0;
- force_fft = 0;
- fftscore = 1;
- fftRepeatStop = 0;
- fftNoAnchStop = 0;
- weight = 3;
- utree = 1;
- tbutree = 1;
- refine = 0;
- check = 1;
- cut = 0.0;
- disp = 0;
- outgap = 1;
- alg = 'A';
- mix = 0;
- tbitr = 0;
- scmtd = 5;
- tbweight = 0;
- tbrweight = 3;
- checkC = 0;
- treemethod = 'X';
- contin = 0;
- scoremtx = 1;
- kobetsubunkatsu = 0;
- dorp = NOTSPECIFIED;
- ppenalty = -1530;
- ppenalty_ex = NOTSPECIFIED;
- poffset = -123;
- kimuraR = NOTSPECIFIED;
- pamN = NOTSPECIFIED;
- geta2 = GETA2;
- fftWinSize = NOTSPECIFIED;
- fftThreshold = NOTSPECIFIED;
- TMorJTT = JTT;
-
- while( --argc > 0 && (*++argv)[0] == '-' )
- {
- while ( (c = *++argv[0]) )
- {
- switch( c )
- {
- case 'i':
- inputfile = *++argv;
- fprintf( stderr, "inputfile = %s\n", inputfile );
- --argc;
- goto nextoption;
- case 'f':
- ppenalty = (int)( atof( *++argv ) * 1000 - 0.5 );
-// fprintf( stderr, "ppenalty = %d\n", ppenalty );
- --argc;
- goto nextoption;
- case 'g':
- ppenalty_ex = (int)( atof( *++argv ) * 1000 - 0.5 );
- fprintf( stderr, "ppenalty_ex = %d\n", ppenalty_ex );
- --argc;
- goto nextoption;
- case 'h':
- poffset = (int)( atof( *++argv ) * 1000 - 0.5 );
-// fprintf( stderr, "poffset = %d\n", poffset );
- --argc;
- goto nextoption;
- case 'k':
- kimuraR = atoi( *++argv );
- fprintf( stderr, "kappa = %d\n", kimuraR );
- --argc;
- goto nextoption;
- case 'b':
- nblosum = atoi( *++argv );
- scoremtx = 1;
-// fprintf( stderr, "blosum %d / kimura 200 \n", nblosum );
- --argc;
- goto nextoption;
- case 'j':
- pamN = atoi( *++argv );
- scoremtx = 0;
- TMorJTT = JTT;
- fprintf( stderr, "jtt/kimura %d\n", pamN );
- --argc;
- goto nextoption;
- case 'm':
- pamN = atoi( *++argv );
- scoremtx = 0;
- TMorJTT = TM;
- fprintf( stderr, "tm %d\n", pamN );
- --argc;
- goto nextoption;
-#if 1
- case 'a':
- fmodel = 1;
- break;
-#endif
- case 'y':
- distout = 1;
- break;
- case 't':
- treeout = 1;
- break;
- case 'T':
- noalign = 1;
- break;
- case 'r':
- fmodel = -1;
- break;
- case 'D':
- dorp = 'd';
- break;
- case 'P':
- dorp = 'p';
- break;
- case 'e':
- fftscore = 0;
- break;
- case 'O':
- fftNoAnchStop = 1;
- break;
-#if 0
- case 'R':
- fftRepeatStop = 1;
- break;
-#endif
- case 's':
- treemethod = 's';
- break;
- case 'X':
- treemethod = 'X'; // mix
- break;
- case 'E':
- treemethod = 'E'; // upg (average)
- break;
- case 'q':
- treemethod = 'q'; // minimum
- break;
-#if 0
- case 'a':
- alg = 'a';
- break;
-#endif
- case 'R':
- alg = 'R';
- break;
- case 'Q':
- alg = 'Q';
- break;
- case 'H':
- alg = 'H';
- break;
- case 'A':
- alg = 'A';
- break;
- case 'N':
- nevermemsave = 1;
- break;
- case 'M':
- alg = 'M';
- break;
- case 'B':
- break;
- case 'S':
- alg = 'S';
- break;
- case 'C':
- alg = 'C';
- break;
- case 'F':
- use_fft = 1;
- break;
- case 'G':
- use_fft = 1;
- force_fft = 1;
- break;
- case 'V':
- topin = 1;
- break;
- case 'U':
- treein = 1;
- break;
- case 'u':
- weight = 0;
- tbrweight = 0;
- break;
- case 'v':
- tbrweight = 3;
- break;
- case 'd':
- disp = 1;
- break;
- case 'o':
- outgap = 0;
- break;
- case 'J':
- tbutree = 0;
- break;
- case 'z':
- fftThreshold = atoi( *++argv );
- --argc;
- goto nextoption;
- case 'w':
- fftWinSize = atoi( *++argv );
- --argc;
- goto nextoption;
- case 'Z':
- checkC = 1;
- break;
- default:
- fprintf( stderr, "illegal option %c\n", c );
- argc = 0;
- break;
- }
- }
- nextoption:
- ;
- }
- if( argc == 1 )
- {
- cut = atof( (*argv) );
- argc--;
- }
- if( argc != 0 )
- {
- fprintf( stderr, "options: Check source file !\n" );
- exit( 1 );
- }
- if( tbitr == 1 && outgap == 0 )
- {
- fprintf( stderr, "conflicting options : o, m or u\n" );
- exit( 1 );
- }
- if( alg == 'C' && outgap == 0 )
- {
- fprintf( stderr, "conflicting options : C, o\n" );
- exit( 1 );
- }
-}
-
-static int maxl;
-static int tsize;
-
-void seq_grp_nuc( int *grp, char *seq )
-{
- int tmp;
- int *grpbk = grp;
- while( *seq )
- {
- tmp = amino_grp[(int)*seq++];
- if( tmp < 4 )
- *grp++ = tmp;
- else
- fprintf( stderr, "WARNING : Unknown character %c\r", *(seq-1) );
- }
- *grp = END_OF_VEC;
- if( grp - grpbk < 6 )
- {
- fprintf( stderr, "\n\nWARNING: Too short.\nPlease also consider use mafft-ginsi, mafft-linsi or mafft-ginsi.\n\n\n" );
-// exit( 1 );
- *grpbk = -1;
- }
-}
-
-void seq_grp( int *grp, char *seq )
-{
- int tmp;
- int *grpbk = grp;
- while( *seq )
- {
- tmp = amino_grp[(int)*seq++];
- if( tmp < 6 )
- *grp++ = tmp;
- else
- fprintf( stderr, "WARNING : Unknown character %c\r", *(seq-1) );
- }
- *grp = END_OF_VEC;
- if( grp - grpbk < 6 )
- {
- fprintf( stderr, "\n\nWARNING: Too short.\nPlease also consider use mafft-ginsi, mafft-linsi or mafft-ginsi.\n\n\n" );
-// exit( 1 );
- *grpbk = -1;
- }
-}
-
-void makecompositiontable_p( short *table, int *pointt )
-{
- int point;
-
- while( ( point = *pointt++ ) != END_OF_VEC )
- table[point]++;
-}
-
-int commonsextet_p( short *table, int *pointt )
-{
- int value = 0;
- short tmp;
- int point;
- static short *memo = NULL;
- static int *ct = NULL;
- static int *cp;
-
- if( *pointt == -1 )
- return( 0 );
-
- if( !memo )
- {
- memo = (short *)calloc( tsize, sizeof( short ) );
- if( !memo ) ErrorExit( "Cannot allocate memo\n" );
- ct = (int *)calloc( MIN( maxl, tsize )+1, sizeof( int ) );
- if( !ct ) ErrorExit( "Cannot allocate memo\n" );
- }
-
- cp = ct;
- while( ( point = *pointt++ ) != END_OF_VEC )
- {
- tmp = memo[point]++;
- if( tmp < table[point] )
- value++;
- if( tmp == 0 ) *cp++ = point;
- }
- *cp = END_OF_VEC;
-
- cp = ct;
- while( *cp != END_OF_VEC )
- memo[*cp++] = 0;
-
- return( value );
-}
-
-void makepointtable_nuc( int *pointt, int *n )
-{
- int point;
- register int *p;
-
- if( *n == -1 )
- {
- *pointt = -1;
- return;
- }
-
- p = n;
- point = *n++ * 1024;
- point += *n++ * 256;
- point += *n++ * 64;
- point += *n++ * 16;
- point += *n++ * 4;
- point += *n++;
- *pointt++ = point;
-
- while( *n != END_OF_VEC )
- {
- point -= *p++ * 1024;
- point *= 4;
- point += *n++;
- *pointt++ = point;
- }
- *pointt = END_OF_VEC;
-}
-
-void makepointtable( int *pointt, int *n )
-{
- int point;
- register int *p;
-
- if( *n == -1 )
- {
- *pointt = -1;
- return;
- }
-
- p = n;
- point = *n++ * 7776;
- point += *n++ * 1296;
- point += *n++ * 216;
- point += *n++ * 36;
- point += *n++ * 6;
- point += *n++;
- *pointt++ = point;
-
- while( *n != END_OF_VEC )
- {
- point -= *p++ * 7776;
- point *= 6;
- point += *n++;
- *pointt++ = point;
- }
- *pointt = END_OF_VEC;
-}
-
-void treebase( int *nlen, char **aseq, char **mseq1, char **mseq2, int ***topol, double *effarr, int *alloclen )
-{
- int l, len1, len2;
- int clus1, clus2;
- float pscore, tscore;
- static char *indication1, *indication2;
- static double *effarr1 = NULL;
- static double *effarr2 = NULL;
- static int *fftlog; // fixed at 2006/07/26
- float dumfl = 0.0;
- int ffttry;
- int m1, m2;
-#if 0
- int i, j;
-#endif
-
-
- if( effarr1 == NULL )
- {
- effarr1 = AllocateDoubleVec( njob );
- effarr2 = AllocateDoubleVec( njob );
- indication1 = AllocateCharVec( 150 );
- indication2 = AllocateCharVec( 150 );
- fftlog = AllocateIntVec( njob );
- }
- for( l=0; l<njob; l++ ) fftlog[l] = 1;
-
-#if 0
- fprintf( stderr, "##### fftwinsize = %d, fftthreshold = %d\n", fftWinSize, fftThreshold );
-#endif
-
-#if 0
- for( i=0; i<njob; i++ )
- fprintf( stderr, "TBFAST effarr[%d] = %f\n", i, effarr[i] );
-#endif
-
-// for( i=0; i<njob; i++ ) strcpy( aseq[i], seq[i] );
-
-
-// writePre( njob, name, nlen, aseq, 0 );
-
- tscore = 0.0;
- for( l=0; l<njob-1; l++ )
- {
- m1 = topol[l][0][0];
- m2 = topol[l][1][0];
- len1 = strlen( aseq[m1] );
- len2 = strlen( aseq[m2] );
- if( *alloclen < len1 + len2 )
- {
- fprintf( stderr, "\nReallocating.." );
- *alloclen = ( len1 + len2 ) + 1000;
- ReallocateCharMtx( aseq, njob, *alloclen + 10 );
- fprintf( stderr, "done. *alloclen = %d\n", *alloclen );
- }
-
-#if 1 // CHUUI@@@@
- clus1 = fastconjuction_noname( topol[l][0], aseq, mseq1, effarr1, effarr, indication1 );
- clus2 = fastconjuction_noname( topol[l][1], aseq, mseq2, effarr2, effarr, indication2 );
-#else
- clus1 = fastconjuction_noweight( topol[l][0], aseq, mseq1, effarr1, indication1 );
- clus2 = fastconjuction_noweight( topol[l][1], aseq, mseq2, effarr2, indication2 );
-#endif
-
-
-#if 0
- for( i=0; i<clus1; i++ )
- {
- if( strlen( mseq1[i] ) != len1 )
- {
- fprintf( stderr, "i = %d / %d\n", i, clus1 );
- fprintf( stderr, "hairetsu ga kowareta (in treebase, after conjuction) !\n" );
- exit( 1 );
- }
- }
- for( j=0; j<clus2; j++ )
- {
- if( strlen( mseq2[j] ) != len2 )
- {
- fprintf( stderr, "j = %d / %d\n", j, clus2 );
- fprintf( stderr, "hairetsu ga kowareta (in treebase, after conjuction) !\n" );
- exit( 1 );
- }
- }
-#endif
-
- free( topol[l][0] );
- free( topol[l][1] );
-
-#if 0
- for( i=0; i<clus1; i++ )
- {
- if( strlen( mseq1[i] ) != len1 )
- {
- fprintf( stderr, "i = %d / %d\n", i, clus1 );
- fprintf( stderr, "hairetsu ga kowareta (in treebase, after free topol) !\n" );
- exit( 1 );
- }
- }
- for( j=0; j<clus2; j++ )
- {
- if( strlen( mseq2[j] ) != len2 )
- {
- fprintf( stderr, "j = %d / %d\n", j, clus2 );
- fprintf( stderr, "hairetsu ga kowareta (in treebase, after free topol) !\n" );
- exit( 1 );
- }
- }
-#endif
-
-
-// fprintf( trap_g, "\nSTEP-%d\n", l );
-// fprintf( trap_g, "group1 = %s\n", indication1 );
-// fprintf( trap_g, "group2 = %s\n", indication2 );
-
-// fprintf( stderr, "\rSTEP % 5d / %d %d-%d", l+1, njob-1, clus1, clus2 );
- fprintf( stderr, "\rSTEP % 5d / %d ", l+1, njob-1 );
-
-#if 0
- fprintf( stderr, "STEP %d /%d\n", l+1, njob-1 );
- fprintf( stderr, "group1 = %.66s", indication1 );
- if( strlen( indication1 ) > 66 ) fprintf( stderr, "..." );
- fprintf( stderr, "\n" );
- fprintf( stderr, "group2 = %.66s", indication2 );
- if( strlen( indication2 ) > 66 ) fprintf( stderr, "..." );
- fprintf( stderr, "\n" );
-#endif
-
-/*
- fprintf( stderr, "before align all\n" );
- display( aseq, njob );
- fprintf( stderr, "\n" );
- fprintf( stderr, "before align 1 %s \n", indication1 );
- display( mseq1, clus1 );
- fprintf( stderr, "\n" );
- fprintf( stderr, "before align 2 %s \n", indication2 );
- display( mseq2, clus2 );
- fprintf( stderr, "\n" );
-*/
-
-
- if( !nevermemsave && ( alg != 'M' && ( len1 > 10000 || len2 > 10000 ) ) )
- {
- fprintf( stderr, "\nlen1=%d, len2=%d, Switching to the memsave mode\n", len1, len2 );
- alg = 'M';
- if( commonIP ) FreeIntMtx( commonIP );
- commonAlloc1 = 0;
- commonAlloc2 = 0;
- }
-
-// if( fftlog[m1] && fftlog[m2] ) ffttry = ( nlen[m1] > clus1 && nlen[m2] > clus2 );
- if( fftlog[m1] && fftlog[m2] ) ffttry = ( nlen[m1] > clus1 && nlen[m2] > clus2 && clus1 < 1000 && clus2 < 1000);
- else ffttry = 0;
-// ffttry = ( nlen[m1] > clus1 && nlen[m2] > clus2 && clus1 < 5000 && clus2 < 5000); // v6.708
-// fprintf( stderr, "f=%d, len1/fftlog[m1]=%f, clus1=%d, len2/fftlog[m2]=%f, clus2=%d\n", ffttry, (float)len1/fftlog[m1], clus1, (float)len2/fftlog[m2], clus2 );
-
- if( force_fft || ( use_fft && ffttry ) )
- {
- fprintf( stderr, "f" );
- if( alg == 'M' )
- {
- fprintf( stderr, "m" );
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = Falign_udpari_long( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, fftlog+m1 );
- }
- else
- {
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = Falign( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, fftlog+m1 );
- }
- }
- else
- {
- fprintf( stderr, "d" );
- fftlog[m1] = 0;
- switch( alg )
- {
- case( 'a' ):
- pscore = Aalign( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen );
- break;
- case( 'M' ):
- fprintf( stderr, "m" );
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = MSalignmm( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, NULL, NULL, NULL, NULL );
- break;
- case( 'Q' ):
- if( clus1 == 1 && clus2 == 1 && 0 )
- {
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = G__align11( mseq1, mseq2, *alloclen );
- }
- else
- {
- pscore = Q__align( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, NULL, &dumfl, NULL, NULL, NULL, NULL );
- }
- break;
- case( 'R' ):
- pscore = R__align( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, NULL, &dumfl, NULL, NULL, NULL, NULL );
- break;
- case( 'H' ):
- pscore = H__align( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, NULL, &dumfl, NULL, NULL, NULL, NULL );
- break;
- case( 'A' ):
- if( clus1 == 1 && clus2 == 1 )
- {
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = G__align11( mseq1, mseq2, *alloclen );
- }
- else
- {
-// fprintf( stderr, "%d-%d", clus1, clus2 );
- pscore = A__align( mseq1, mseq2, effarr1, effarr2, clus1, clus2, *alloclen, NULL, &dumfl, NULL, NULL, NULL, NULL );
- }
- break;
- default:
- ErrorExit( "ERROR IN SOURCE FILE" );
- }
- }
-#if SCOREOUT
- fprintf( stderr, "score = %10.2f\n", pscore );
-#endif
- tscore += pscore;
- nlen[m1] = 0.5 * ( nlen[m1] + nlen[m2] );
-
-// writePre( njob, name, nlen, aseq, 0 );
-
- if( disp ) display( aseq, njob );
-// fprintf( stderr, "\n" );
- }
-#if SCOREOUT
- fprintf( stderr, "totalscore = %10.2f\n\n", tscore );
-#endif
-}
-
-static void WriteOptions( FILE *fp )
-{
-
- if( dorp == 'd' ) fprintf( fp, "DNA\n" );
- else
- {
- if ( scoremtx == 0 ) fprintf( fp, "JTT %dPAM\n", pamN );
- else if( scoremtx == 1 ) fprintf( fp, "BLOSUM %d\n", nblosum );
- else if( scoremtx == 2 ) fprintf( fp, "M-Y\n" );
- }
- fprintf( stderr, "Gap Penalty = %+5.2f, %+5.2f, %+5.2f\n", (double)ppenalty/1000, (double)ppenalty_ex/1000, (double)poffset/1000 );
- if( use_fft ) fprintf( fp, "FFT on\n" );
-
- fprintf( fp, "tree-base method\n" );
- if( tbrweight == 0 ) fprintf( fp, "unweighted\n" );
- else if( tbrweight == 3 ) fprintf( fp, "clustalw-like weighting\n" );
- if( tbitr || tbweight )
- {
- fprintf( fp, "iterate at each step\n" );
- if( tbitr && tbrweight == 0 ) fprintf( fp, " unweighted\n" );
- if( tbitr && tbrweight == 3 ) fprintf( fp, " reversely weighted\n" );
- if( tbweight ) fprintf( fp, " weighted\n" );
- fprintf( fp, "\n" );
- }
-
- fprintf( fp, "Gap Penalty = %+5.2f, %+5.2f, %+5.2f\n", (double)ppenalty/1000, (double)ppenalty_ex/1000, (double)poffset/1000 );
-
- if( alg == 'a' )
- fprintf( fp, "Algorithm A\n" );
- else if( alg == 'A' )
- fprintf( fp, "Algorithm A+\n" );
- else if( alg == 'S' )
- fprintf( fp, "Apgorithm S\n" );
- else if( alg == 'C' )
- fprintf( fp, "Apgorithm A+/C\n" );
- else
- fprintf( fp, "Unknown algorithm\n" );
-
- if( treemethod == 'X' )
- fprintf( fp, "Tree = UPGMA (mix).\n" );
- else if( treemethod == 'E' )
- fprintf( fp, "Tree = UPGMA (average).\n" );
- else if( treemethod == 'q' )
- fprintf( fp, "Tree = Minimum linkage.\n" );
- else
- fprintf( fp, "Unknown tree.\n" );
-
- if( use_fft )
- {
- fprintf( fp, "FFT on\n" );
- if( dorp == 'd' )
- fprintf( fp, "Basis : 4 nucleotides\n" );
- else
- {
- if( fftscore )
- fprintf( fp, "Basis : Polarity and Volume\n" );
- else
- fprintf( fp, "Basis : 20 amino acids\n" );
- }
- fprintf( fp, "Threshold of anchors = %d%%\n", fftThreshold );
- fprintf( fp, "window size of anchors = %dsites\n", fftWinSize );
- }
- else
- fprintf( fp, "FFT off\n" );
- fflush( fp );
-}
-
-
-int main( int argc, char *argv[] )
-{
- static int *nlen;
- static int *nogaplen;
- static char **name, **seq;
- static char **mseq1, **mseq2;
- static char **bseq;
- static double *eff;
- int i, j;
- static int ***topol;
- static float **len;
- FILE *infp;
- char c;
- int alloclen;
- float longer, shorter;
- float lenfac;
- float bunbo;
-
- FILE *orderfp, *hat2p;
- int *grpseq;
- char *tmpseq;
- int **pointt;
- float **mtx = NULL; // by D. Mathog
- static short *table1;
- char b[B];
- int ien;
-
-
-
- arguments( argc, argv );
-
- if( inputfile )
- {
- infp = fopen( inputfile, "r" );
- if( !infp )
- {
- fprintf( stderr, "Cannot open %s\n", inputfile );
- exit( 1 );
- }
- }
- else
- infp = stdin;
-
- getnumlen( infp );
- rewind( infp );
-
- if( njob > 20000 )
- {
- fprintf( stderr, "The number of sequences must be < %d\n", 20000 );
- fprintf( stderr, "Please try the --parttree option for such large data.\n" );
- exit( 1 );
- }
-
- if( njob < 2 )
- {
- fprintf( stderr, "At least 2 sequences should be input!\n"
- "Only %d sequence found.\n", njob );
- exit( 1 );
- }
-
- seq = AllocateCharMtx( njob, nlenmax*1+1 );
- mseq1 = AllocateCharMtx( njob, 0 );
- mseq2 = AllocateCharMtx( njob, 0 );
-
- topol = AllocateIntCub( njob, 2, 0 );
- len = AllocateFloatMtx( njob, 2 );
- eff = AllocateDoubleVec( njob );
-
-
-#if 0
- Read( name, nlen, seq );
- readData( infp, name, nlen, seq );
-#else
- name = AllocateCharMtx( njob, B+1 );
- nlen = AllocateIntVec( njob );
- nogaplen = AllocateIntVec( njob );
- readData_pointer( infp, name, nlen, seq );
-#endif
- fclose( infp );
-
- constants( njob, seq );
-
-
-#if 0
- fprintf( stderr, "params = %d, %d, %d\n", penalty, penalty_ex, offset );
-#endif
-
- initSignalSM();
-
- initFiles();
-
- WriteOptions( trap_g );
-
- c = seqcheck( seq );
- if( c )
- {
- fprintf( stderr, "Illegal character %c\n", c );
- exit( 1 );
- }
-
- fprintf( stderr, "\n" );
-
- if( !treein )
- {
- fprintf( stderr, "\n\nMaking a distance matrix ..\n" );
-
- tmpseq = AllocateCharVec( nlenmax+1 );
- grpseq = AllocateIntVec( nlenmax+1 );
- pointt = AllocateIntMtx( njob, nlenmax+1 );
- mtx = AllocateFloatHalfMtx( njob );
- if( dorp == 'd' ) tsize = (int)pow( 4, 6 );
- else tsize = (int)pow( 6, 6 );
-
- if( dorp == 'd' )
- {
- lenfaca = DLENFACA;
- lenfacb = DLENFACB;
- lenfacc = DLENFACC;
- lenfacd = DLENFACD;
- }
- else
- {
- lenfaca = PLENFACA;
- lenfacb = PLENFACB;
- lenfacc = PLENFACC;
- lenfacd = PLENFACD;
- }
-
- maxl = 0;
- for( i=0; i<njob; i++ )
- {
- gappick0( tmpseq, seq[i] );
- nogaplen[i] = strlen( tmpseq );
- if( nogaplen[i] < 6 )
- {
-// fprintf( stderr, "Seq %d, too short, %d characters\n", i+1, nogaplen[i] );
-// fprintf( stderr, "Please use mafft-ginsi, mafft-linsi or mafft-ginsi\n\n\n" );
-// exit( 1 );
- }
- if( nogaplen[i] > maxl ) maxl = nogaplen[i];
- if( dorp == 'd' ) /* nuc */
- {
- seq_grp_nuc( grpseq, tmpseq );
- makepointtable_nuc( pointt[i], grpseq );
- }
- else /* amino */
- {
- seq_grp( grpseq, tmpseq );
- makepointtable( pointt[i], grpseq );
- }
- }
- for( i=0; i<njob; i++ )
- {
- table1 = (short *)calloc( tsize, sizeof( short ) );
- if( !table1 ) ErrorExit( "Cannot allocate table1\n" );
- if( i % 10 == 0 )
- {
- fprintf( stderr, "\r% 5d / %d", i+1, njob );
- }
- makecompositiontable_p( table1, pointt[i] );
-
- for( j=i; j<njob; j++ )
- {
- mtx[i][j-i] = (float)commonsextet_p( table1, pointt[j] );
- }
- free( table1 );
- }
- fprintf( stderr, "\ndone.\n\n" );
- ien = njob-1;
-
- for( i=0; i<ien; i++ )
- {
- for( j=i+1; j<njob; j++ )
- {
- if( nogaplen[i] > nogaplen[j] )
- {
- longer=(float)nogaplen[i];
- shorter=(float)nogaplen[j];
- }
- else
- {
- longer=(float)nogaplen[j];
- shorter=(float)nogaplen[i];
- }
-// lenfac = 3.0 / ( LENFACA + LENFACB / ( longer + LENFACC ) + shorter / longer * LENFACD );
- lenfac = 1.0 / ( shorter / longer * lenfacd + lenfacb / ( longer + lenfacc ) + lenfaca );
-// lenfac = 1.0;
-// fprintf( stderr, "lenfac = %f (%.0f,%.0f)\n", lenfac, longer, shorter );
- bunbo = MIN( mtx[i][0], mtx[j][0] );
- if( bunbo == 0.0 )
- mtx[i][j-i] = 1.0;
- else
- mtx[i][j-i] = ( 1.0 - mtx[i][j-i] / bunbo ) * lenfac;
-// fprintf( stdout, "##### mtx = %f, mtx[i][0]=%f, mtx[j][0]=%f, bunbo=%f\n", mtx[i][j-i], mtx[i][0], mtx[j][0], bunbo );
- }
- }
- if( disopt )
- {
- for( i=0; i<njob; i++ )
- {
- sprintf( b, "=lgth = %04d", nogaplen[i] );
- strins( b, name[i] );
- }
- }
- free( grpseq );
- free( tmpseq );
- FreeIntMtx( pointt );
-
-#if 1 // writehat2 wo kakinaosu
- if( distout )
- {
- hat2p = fopen( "hat2", "w" );
- WriteFloatHat2_pointer_halfmtx( hat2p, njob, name, mtx );
- fclose( hat2p );
- }
-#endif
-
- }
- else {
-#if 0 // readhat2 wo kakinaosu
- fprintf( stderr, "Loading 'hat2' ... " );
- prep = fopen( "hat2", "r" );
- if( prep == NULL ) ErrorExit( "Make hat2." );
- readhat2_float( prep, njob, name, mtx ); // name chuui
- fclose( prep );
- fprintf( stderr, "done.\n" );
-#endif
- }
-
- if( treein )
- {
- fprintf( stderr, "Loading a tree ... " );
- loadtree( njob, topol, len, name, nogaplen );
- }
- else if( topin )
- {
- fprintf( stderr, "Loading a topology ... " );
- loadtop( njob, mtx, topol, len );
- FreeFloatHalfMtx( mtx, njob );
- }
- else if( treeout )
- {
- fprintf( stderr, "Constructing a UPGMA tree ... " );
-
- fixed_musclesupg_float_realloc_nobk_halfmtx_treeout( njob, mtx, topol, len, name, nogaplen );
-// veryfastsupg_float_realloc_nobk_halfmtx_treeout( njob, mtx, topol, len, name, nogaplen );
-
-
- FreeFloatHalfMtx( mtx, njob );
- }
- else
- {
- fprintf( stderr, "Constructing a UPGMA tree ... " );
- fixed_musclesupg_float_realloc_nobk_halfmtx( njob, mtx, topol, len );
- FreeFloatHalfMtx( mtx, njob );
- }
-// else
-// ErrorExit( "Incorrect tree\n" );
- fprintf( stderr, "\ndone.\n\n" );
-
- orderfp = fopen( "order", "w" );
- if( !orderfp )
- {
- fprintf( stderr, "Cannot open 'order'\n" );
- exit( 1 );
- }
- for( i=0; (j=topol[njob-2][0][i])!=-1; i++ )
- {
- fprintf( orderfp, "%d\n", j );
- }
- for( i=0; (j=topol[njob-2][1][i])!=-1; i++ )
- {
- fprintf( orderfp, "%d\n", j );
- }
- fclose( orderfp );
-
- if( ( treeout || distout ) && noalign )
- {
- writeData_pointer( stdout, njob, name, nlen, seq );
- fprintf( stderr, "\n" );
- SHOWVERSION;
- return( 0 );
- }
-
-
- if( tbrweight )
- {
- weight = 3;
-#if 0
- utree = 0; counteff( njob, topol, len, eff ); utree = 1;
-#else
- counteff_simple_float( njob, topol, len, eff );
-#endif
- }
- else
- {
- for( i=0; i<njob; i++ ) eff[i] = 1.0;
- }
-
-#if 0
- for( i=0; i<njob; i++ )
- fprintf( stdout, "eff[%d] = %20.16f\n", i, eff[i] );
- exit( 1 );
-#endif
-
-
- FreeFloatMtx( len );
-
- bseq = AllocateCharMtx( njob, nlenmax*2+1 );
- alloclen = nlenmax*2;
- for( i=0; i<njob; i++ ) gappick0( bseq[i], seq[i] );
-
- fprintf( stderr, "Progressive alignment ... \n" );
- treebase( nlen, bseq, mseq1, mseq2, topol, eff, &alloclen );
- fprintf( stderr, "\ndone.\n\n" );
-#if DEBUG
- fprintf( stderr, "closing trap_g\n" );
-#endif
- fclose( trap_g );
-
-// writePre( njob, name, nlen, aseq, !contin );
-#if DEBUG
- fprintf( stderr, "writing alignment to stdout\n" );
-#endif
- writeData_pointer( stdout, njob, name, nlen, bseq );
-#if 0
- writeData( stdout, njob, name, nlen, bseq );
-#endif
-#if IODEBUG
- fprintf( stderr, "OSHIMAI\n" );
-#endif
- SHOWVERSION;
- return( 0 );
-}