+++ /dev/null
-/*
- Current free energy parameters are summarized in:
-
- D.H.Mathews, J. Sabina, M. ZUker, D.H. Turner
- "Expanded sequence dependence of thermodynamic parameters improves
- prediction of RNA secondary structure"
- JMB, 288, pp 911-940, 1999
-
- Enthalpies taken from:
-
- A. Walter, D Turner, J Kim, M Lyttle, P M"uller, D Mathews, M Zuker
- "Coaxial stckaing of helices enhances binding of oligoribonucleotides.."
- PNAS, 91, pp 9218-9222, 1994
-
- D.H. Turner, N. Sugimoto, and S.M. Freier.
- "RNA Structure Prediction",
- Ann. Rev. Biophys. Biophys. Chem. 17, 167-192, 1988.
-
- John A.Jaeger, Douglas H.Turner, and Michael Zuker.
- "Improved predictions of secondary structures for RNA",
- PNAS, 86, 7706-7710, October 1989.
-
- L. He, R. Kierzek, J. SantaLucia, A.E. Walter, D.H. Turner
- "Nearest-Neughbor Parameters for GU Mismatches...."
- Biochemistry 1991, 30 11124-11132
-
- A.E. Peritz, R. Kierzek, N, Sugimoto, D.H. Turner
- "Thermodynamic Study of Internal Loops in Oligoribonucleotides..."
- Biochemistry 1991, 30, 6428--6435
-
-
-*/
-
-#ifndef ENERGY_PARAM_H
-#define ENERGY_PARAM_H
-
-#include <iostream>
-#include <cstdlib> // by katoh
-
-using namespace std;
-namespace MXSCARNA {
-class energy_param {
-
- static const int INF;
- static const int NST;
- static const int DEF;
-
- static const double lxc37; /* parameter for logarithmic loop
- energy extrapolation */
- static const int stack37[8][8];
- static const int enthalpies[8][8];
- static const int oldhairpin37[31];
- static const int hairpin37[31];
- static const int oldbulge37[31];
- static const int bulge37[31];
- static const int oldinternal_loop37[31];
- static const int internal_loop37[31];
- static const int mismatchI37[8][5][5];
- static const int mismatchH37[8][5][5];
- static const int mism_H[8][5][5];
- static const int dangle5_37[8][5];
- static const int dangle3_37[8][5];
- static const int dangle3_H[8][5];
- static const int dangle5_H[8][5];
- static const int ML_BASE37;
- static const int ML_closing37;
- static const int ML_intern37;
- static const int MAX_NINIO;
- static const int F_ninio37[5];
- static const char Tetraloops[1400];
- static const char Tetrastrings[30][7];
- static const int TETRA_ENERGY37[200];
- static const int TETRA_ENTH37;
- static const int TerminalAU;
- static const int DuplexInit;
-
- static const int int11_37[8][8][5][5];
- static const int int11_H[8][8][5][5];
- static const int int21_37[8][8][5][5][5];
- static const int int21_H[8][8][5][5][5];
- static const int int22_37[8][8][5][5][5][5];
- static const int int22_H[8][8][5][5][5][5];
-
- int convertPairType(int type);
- int convertBaseType(int type);
- int convertLeftType(int type);
- int convertRightType(int type);
-
- public:
- int getMaxNinio();
- int getNinio(int i);
- int getDangle5(int i, int j);
- int getDangle3(int i, int j);
- int getHairpin(int i);
- int getInternalLoop(int i);
- int getBulge(int i);
- const char *getTetraLoop(int i);
- int getTetraLoopEnergy(int i);
- int getStack(int i, int j);
- int getTstackH(int i, int j);
- int getTstackI(int i, int j);
- int getInt11(int i, int j, int k);
- int getInt21(int i, int j, int k, int l);
- int getInt22(int i, int j, int k, int l);
- int getMLintern();
- int getMLBase();
- int getMLclosing();
- int getTerminalAU();
-};
-}
-#endif