+++ /dev/null
-2016-07-01 Release 1.2.2 (AndreaGiacomo)
-
- - fixed a memory leak in hhalign
- - paralleised hhalign
- - increased MAC-RAM default from 2GB to 8GB
-
- (no new command-line flags)
-
-2014-02-28 Release 1.2.1 (AndreaGiacomo)
-
- - corrected Clustal format consensus line
- - label justification (multi-bit)
-
-2013-06-12 Release 1.2.0 (AndreaGiacomo)
-
- --is-profile disable check if profile, force profile (default no)
- --use-kimura use Kimura distance correction for aligned sequences (default no)
- --percent-id convert distances into percent identities (default no)
-
- fixed bug in --output-order=tree-order for pair-wise alignment
-
- Kimura distance correction no longer default for protein
-
- fixed bug in Viterbi algorithm (predominantly affected long nucleotide but also protein, to lesser extent)
-
- Viterbi is less (~10x) memory hungry than MAC but still scales quadratically with length:
-
- 2GB of RAM (ClustalO default) can align sequences of 6.5k residues with MAC and 18k with Viterbi
-
- 8GB of RAM (EBI limit) can align sequences of 12.5k residues with MAC and 37k with Viterbi
-
- A Viterbi alignment of sequences of 100k residues will require 59GB of RAM
-
-
-2013-05-16 Release 1.1.1
-
- --cluster-size=<n> soft maximum of sequences in sub-clusters
- --clustering-out=<file> Clustering output file
- --residuenumber, --resno in Clustal format print residue numbers (default no)
- --wrap=<n> number of residues before line-wrap in output
- --output-order={input-order,tree-order} MSA output order like in input/guide-tree
-
- turned off Kimura correction for DNA/RNA
-
- enable distance matrix output after initial mBed but subsequent full distance calculation
-
- enable termination after distance/guide-tree calculation (--max-hmm-iterations=-1)
-
- longer sequence labels
-
-2012-04-25 Release 1.1.0
-
- DNA and RNA support now added. Sequence type can be specified manually
- using --seqtype={Protein|DNA|RNA}
-
-2012-03-27 Release 1.0.4
-
- zipped input now supported
-
-2011-09-07 Release 1.0.3
-
-Bugs fixed:
-
- input failed if first line in fasta file was empty
-
- input failed if Clustal formatted file had trailing residue numbers
-
- '*' character was causing problems, did not get filtered out by squid
-
- --outfmt=fasta was not recognized
-
- '~' gap characters were not recognized in MSF format
-
- amended README re sequence/profile alignment
-
- disallowed empty sequences
-
- doxygen documentation fixes and fix of API example
-
- introduced MAC-RAM flag to set amount of RAM given to MAC (in MB)
-
-2011-06-23 Release 1.0.2
-
-2011-06-17 Release 1.0.0 (DeshilHollesEamus)
-
-2010-06-17 Release 0.0.1 (Dubliniensis)
-
- First "release" as program has been able for a while to perform
- all basic tasks without problems.
-
- Non-standard features already built-in include:
- HMM-iteration (using HMMER for building an HMM) and guide-tree
- iteration. On top of that HMM input works fine and
- background-frequencies are added to the HHalign process.
-
- Known issues: RNA/DNA alignment is considered buggy. Aligned
- sequences have to be dealigned for HHalign to work properly.
-
- The HMMER version message can be ignored if no HMM-iteration
- was used.